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    589 results match your criteria Eosinophilia-Myalgia Syndrome

    1 OF 12

    Structure determination of disease associated peak AAA from l-Tryptophan implicated in the eosinophilia-myalgia syndrome.
    Toxicol Lett 2018 Jan 14;282:71-80. Epub 2017 Oct 14.
    ReNeuroGen LLC, Milwaukee, WI 53122, USA. Electronic address:
    The eosinophilia-myalgia syndrome (EMS) outbreak of 1989 that occurred in the USA and elsewhere was caused by the ingestion of l-Tryptophan (L-Trp) solely manufactured by the Japanese company Showa Denko K.K. (SD). Read More

    Serpiginous Purpuric Eruption of the Leg.
    J Drugs Dermatol 2017 Oct;16(10):1036-1038
    A previously healthy 68-year-old male presented with a rash on his right lower leg. The lesions had spread along the leg since onset 9 days prior, and the patient reported localized soreness and pruritus. He denied systemic symptoms including fever, fatigue, myalgia, joint pain, and recent illness. Read More

    Two Catastrophes in One Patient: Drug Reaction with Eosinophilia and Systemic Symptoms and Toxic Shock Syndrome.
    Cureus 2017 Jun 15;9(6):e1359. Epub 2017 Jun 15.
    Internal Medicine, Quillen College of Medicine at East Tennessee State University.
    A 70-year-old, immunocompromised patient presented to the emergency room (ER) five weeks after she was started on clopidogrel. She complained of skin eruption, mouth ulcers, fatigue, and myalgia over the past two weeks. Labs showed severe hyponatremia, acute kidney injury, rhabdomyolysis, hyperkalemia, and elevated liver enzymes. Read More

    Possible Parkinson's Disease Induced by Chronic Manganese Supplement Ingestion.
    Consult Pharm 2016 Dec;31(12):698-703
    Objective: The objective is to report a case of possible neurotoxicity resulting from an incorrect dietary supplement for osteoporosis taken at a toxic dose.

    Summary: The case study examined here is a 37-year-old African-American female who consumed excessive manganese over a period of years, resulting in Parkinson's disease (PD). This patient was referred to the pharmacist pharmacotherapy service by a neurology physician. Read More

    Febuxostat-associated eosinophilic polymyositis in marginal zone lymphoma.
    Joint Bone Spine 2017 Mar 7;84(2):221-223. Epub 2016 Dec 7.
    Department of Rheumatology, Faculty of Medicine, Saint-Joseph university, Hotel-Dieu de France, Beirut, Lebanon.
    Febuxostat is an orally administered selective inhibitor of xanthine oxidase approved for the treatment of gout and prevention of tumor lysis syndrome. It is a relatively safe medication. Hypersensitivity reactions associated with the use of febuxostat are quite rare with only one reported case of DRESS syndrome. Read More

    The Importance of Quality Specifications in Safety Assessments of Amino Acids: The Cases of l-Tryptophan and l-Citrulline.
    J Nutr 2016 Dec 9;146(12):2643S-2651S. Epub 2016 Nov 9.
    US Pharmacopeial Convention, Rockville, MD.
    The increasing consumption of amino acids from a wide variety of sources, including dietary supplements, natural health products, medical foods, infant formulas, athletic and work-out products, herbal medicines, and other national and international categories of nutritional and functional food products, increases the exposure to amino acids to amounts far beyond those normally obtained from the diet, thereby necessitating appropriate and robust safety assessments of these ingredients. Safety assessments of amino acids, similar to all food constituents, largely rely on the establishment of an upper limit [Tolerable Upper Intake Level (UL)] considered to be a guide for avoiding high intake, above which adverse or toxic effects might occur. However, reliable ULs have been difficult or impossible to define for amino acids because of inadequate toxicity studies in animals and scarce or missing clinical data, as well as a paucity or absence of adverse event reporting data. Read More

    [Eosinophilic fasciitis (Shulman's disease): Diagnostic and therapeutic review].
    Rev Med Interne 2015 Nov 16;36(11):738-45. Epub 2015 Sep 16.
    Université Paris-Cité Sorbonne Paris-Diderot, 75013 Paris, France; Service de médecine interne, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France. Electronic address:
    Eosinophilic fasciitis (EF) is a rare connective tissue disease characterized by symmetrical and painful swelling with a progressive induration and thickening of the skin and soft tissues. The diagnosis of EF is often based on the association of characteristic skin or subcutaneous abnormalities and a thickened fascia with an inflammatory infiltration, mostly composed of lymphocytes and eosinophils. A peripheral eosinophilia is frequently present (60-90%) but is not mandatory for the EF diagnosis. Read More

    Eosinophilia in Rheumatologic/Vascular Disorders.
    Immunol Allergy Clin North Am 2015 Aug 17;35(3):453-76. Epub 2015 Jun 17.
    Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, 9500 Euclid Avenue, A50, Cleveland, OH 44195, USA. Electronic address:
    Peripheral and tissue eosinophilia can be a prominent feature of several unique rheumatologic and vascular diseases. These diseases span a wide range of clinical features, histologic findings, therapeutic approaches, and outcomes. Despite the rare nature of these entities--which makes large-scale studies challenging--knowledge has continued to grow regarding their epidemiology, pathophysiology, and management. Read More

    Prediction of drug-induced eosinophilia adverse effect by using SVM and naïve Bayesian approaches.
    Med Biol Eng Comput 2016 Mar 5;54(2-3):361-9. Epub 2015 Jun 5.
    College of Life Science, Northwest Normal University, Lanzhou, 730070, Gansu, People's Republic of China.
    Drug-induced eosinophilia is a potentially life-threatening adverse effect; clinical manifestations, eosinophilia-myalgia syndrome, mainly include severe skin eruption, fever, hematologic abnormalities, and organ system dysfunction. Using experimental methods to evaluate drug-induced eosinophilia is very complicated, time-consuming, and costly in the early stage of drug development. Thus, in this investigation, we established computational prediction models of drug-induced eosinophilia using SVM and naïve Bayesian approaches. Read More

    Muscle pain, fever, cough, and progressive dyspnea in a woman with eosinophilic pneumonia.
    Genet Mol Res 2015 Apr 28;14(2):4189-94. Epub 2015 Apr 28.
    Respiratory Disease Department, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    The diagnosis of eosinophilic pneumonia (EP) is rare and challenging. This condition is frequently misdiagnosed as pulmonary tuberculosis, lymphoma, schistosomiasis, Wegener's granuloma, severe acute respiratory syndrome, or severe community-acquired pneumonia. Herein, we report a case in which computed tomography (CT)-guided percutaneous lung biopsy was used to diagnose EP without alveolar eosinophilia or peripheral eosinophilia. Read More

    [Eosinophilic fasciitis].
    Postepy Hig Med Dosw (Online) 2015 Jan 2;69:488-95. Epub 2015 Jan 2.
    Katedra i Klinika Reumatologii i Chorób Wewnętrznych Uniwersytetu Medycznego w Poznaniu.
    Eosinophilic fasciitis is a rare connective tissue disease with unclear etiology and pathogenesis. It is classified as a scleroderma-like syndrome. The disease is characterized by fibrosis of the skin and subcutaneous tissues with significant thickening of fascia. Read More

    Vasculitis secondary to anti-C1q antibodies induced by Toxocariasis.
    Infection 2015 Dec 26;43(6):755-8. Epub 2015 Mar 26.
    Department of Internal Medicine, Caen University Hospital, Caen, France.
    Introduction: Vasculitides occurring during parasitic infection are rare and may imply different mechanisms.

    Methods: A case report of cutaneous vasculitis and visceral damage during a larva migrans syndrome.

    Results: We report the case of a 64-year-old man who developed a purpura along with fever, respiratory failure, abdominal pain and myalgia. Read More

    Association of eosinophilic fasciitis with morphea.
    Folia Med (Plovdiv) 2014 Jul-Sep;56(3):220-4
    Department of Dermatology and Venereology, Faculty of Medicine, Medical University, Plovdiv
    Eosinophilic fasciitis is a rare inflammatory disease of unknown etiology, described for the first time by Shulman in 1974. The disease presents with induration of the skin, connective tissue and the underlying muscle fascia, sometimes accompanied by myalgia, most commonly in the lower extremities. Unlike scleroderma, it presents with absence of visceral organ involvement and Raynaud's phenomenon. Read More

    Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) presenting as diffuse myositis.
    BMC Musculoskelet Disord 2014 Nov 21;15:388. Epub 2014 Nov 21.
    Department of Internal Medicine, Université de Sherbrooke, 3001 12e Avenue, Fleurimont, QC J1H 5N4, Canada.
    Background: Eosinophilic granulomatosis with polyangiitis is a complex multisystemic syndrome with heterogeneous presentation. Most often, there is a clinical history of asthma or other atopic conditions, and current presentation generally includes signs of cutaneous or pulmonary involvement. Very few reports described myalgia or weakness as the chief complaint. Read More

    Clinical & biochemical profile of trichinellosis outbreak in north India.
    Indian J Med Res 2014 Sep;140(3):414-9
    Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
    Background & Objectives: Trichinellosis is a parasitic infection caused by Trichinella nematodes, acquired from consumption of raw meat. However, data from Indian subcontinent are limited. The aim of this study was to investigate the clinical and biochemical profile of a suspected trichinellosis outbreak in a village in Tehri Garhwal district of Uttarakhand state in north India. Read More

    Acute painful paraplegia in a 49-year-old man with allergic asthma.
    BMJ Case Rep 2014 Jun 30;2014. Epub 2014 Jun 30.
    Division of Pulmonology, S Anna Hospital, San Fermo della Battaglia (CO), Italy.
    We present a case of a 49-year-old man, with a 10-year history of bronchial asthma and nasal polyposis, who developed acutely painful paraplegia and paresthesias. Laboratory data showed elevated blood creatine kinase levels and myoglobinuria, which were diagnostic for rhabdomyolysis but only partially explained the neurological deficit. Electrophysiological studies revealed a sensorimotor neuropathy of multiple mononeuritis type. Read More

    Idiopathic eosinophilic cholecystitis with cholelithiasis: a report of two cases.
    Turk Patoloji Derg 2014 ;30(2):142-4
    Department of Pathology, Lady Hardinge Medical College, NEW DELHI, INDIA.
    Eosinophilic cholecystitis is a rare entity diagnosed on the basis of classical presentation of cholecystitis with presence of more than 90% eosinophilic infiltration within the gall bladder. The etiology of eosinophilic cholecystitis still remains obscure. However it is frequently associated with other more severe diseases like hypereosinophilic syndrome, eosinophilic-myalgia syndrome, parasitic infestations, few herbal medicines and certain drugs. Read More

    Diagnosis and classification of eosinophilic fasciitis.
    Autoimmun Rev 2014 Apr-May;13(4-5):379-82. Epub 2014 Jan 11.
    Muscle Research Unit, Internal Medicine Service, Hospital Clínic de Barcelona, Villarroel 170, 08036 Barcelona, Spain; Fundació Cellex, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain. Electronic address:
    Eosinophilic fasciitis (EF) is a rare scleroderma-like syndrome with an unknown etiology and pathogenesis that should be considered an immune-allergic disorder. Painful swelling with progressive induration and thickening of the skin and soft tissues of the limbs and trunk are the clinical hallmarks of the disease. Peripheral blood eosinophilia, hypergammaglobulinemia, and elevated erythrocyte sedimentation rate are the main laboratory findings. Read More

    Immunohistochemical studies of the kynurenine pathway in morphea.
    Int J Tryptophan Res 2013 23;6:97-102. Epub 2013 Dec 23.
    Zenith Specialist Pathology, South Brisbane, Queensland, Australia.
    Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, skin biopsies were taken from involved and non-involved sites in a series of three patients with morphea. Immunohistochemical stains for quinolinic acid and indoleamine 2,3-dioxygenase (IDO) were performed. Read More

    Successful extracorporeal liver dialysis for the treatment of trimethoprim-sulfamethoxazole-induced fulminant hepatic failure.
    Singapore Med J 2013 May;54(5):e113-6
    Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
    Trimethoprim-sulfamethoxazole (TMP-SMZ) is a commonly used antibiotic that has been associated with drug rash with eosinophilia and systemic symptoms (DRESS) syndrome. DRESS syndrome is characterised by fever, rash, lymphadenopathy, eosinophilia and one or more major organ involvement. Although rare, TMP-SMZ is a recognised cause of fulminant hepatic failure. Read More

    Methimazole-induced myositis: a case report and review of the literature.
    Endocrinol Diabetes Metab Case Rep 2013 30;2013:130008. Epub 2013 Aug 30.
    Department of Gastroenterology Saint Georges University Medical Center, University of Balamand Beirut Lebanon.
    Unlabelled: Methimazole is an anti-thyroid drug commonly used to treat hyperthyroidism and is a relatively safe medication. Several side effects have been reported and usually develop within 3 months of therapy. Well-known adverse reactions include agranulocytosis, hepatitis, skin eruptions, and musculoskeletal complaints such as myalgia, arthralgia, and arthritis. Read More

    Severe eosinophilic syndrome associated with the use of probiotic supplements: a new entity?
    Case Rep Rheumatol 2012 6;2012:934324. Epub 2012 Dec 6.
    Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA 19107, USA ; Rheumatology Division, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
    Severe eosinophilic syndromes related to the administration or use of unsuspected immunogenic substances have been described previously. Many of these diseases presented initially as clusters or isolated cases. The spanish toxic oil syndrome, the eosinophilia myalgia syndrome, and nephrogenic systemic fibrosis are examples of such diseases. Read More

    Leukemoid reaction secondary to hypersensitivity syndrome to phenobarbital: a case report.
    Int J Clin Exp Pathol 2013 20;6(1):100-4. Epub 2012 Nov 20.
    Department of Dermatovenereology, Second Xiangya Hospital, Central South University Changsha, China.
    The most important adverse effects of phenobarbital, an anticonvulsant drug, are behavior and cognitive alterations. Hypersensitivity syndrome caused by phenobarbital presenting with a leukemoid reaction is a rare side effect, which is rarely ever reported and needs to be known. We report on a 27-year-old Chinese woman who experienced hypersensitivity syndrome three weeks after the initiation of phenobarbital. Read More

    Effects and side effects associated with the non-nutritional use of tryptophan by humans.
    J Nutr 2012 Dec 17;142(12):2236S-2244S. Epub 2012 Oct 17.
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
    The daily nutritional requirement for L-tryptophan (Trp) is modest (5 mg/kg). However, many adults choose to consume much more, up to 4-5 g/d (60-70 mg/kg), typically to improve mood or sleep. Ingesting L-Trp raises brain tryptophan levels and stimulates its conversion to serotonin in neurons, which is thought to mediate its actions. Read More

    Eosinophilic fasciitis (Shulman disease).
    Best Pract Res Clin Rheumatol 2012 Aug;26(4):449-58
    Paris Diderot (Paris VII) University, Department of Internal Medicine, Saint-Louis Lariboisière Fernand Widal Hospital Group, Paris, France.
    The eosinophilic fasciitis (EF) is a rare connective tissue disease characterized by symmetrical and painful swelling with a progressive induration and thickening of the skin and soft tissues. The diagnosis of EF is often based on the association of characteristic skin or subcutaneous abnormalities and a thickened fascia with an inflammatory infiltration, mostly composed of lymphocytes and eosinophils. A peripheral eosinophilia is frequently present, but is not mandatory for the EF diagnosis. Read More

    Environmental- and injury-related epidemic-assistance investigations, 1946-2005.
    Am J Epidemiol 2011 Dec;174(11 Suppl):S65-79
    Office of Deputy Director for Non-Communicable Diseases, Injury, and Environmental Health, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, MS F-64, Atlanta, GA 30333, USA.
    This paper summarizes environmental investigations (n = 458) conducted during the first 60 years of the epidemic-assistance investigation program at the Centers for Disease Control and Prevention. These investigations were grouped into 10 categories: toxic chemicals (n = 102), indoor air quality and outdoor air toxics (n = 21), new or rare epidemic diseases and unexplained syndromes (n = 29), natural disasters (n = 81), terrorism and unintentional human-made disasters (n = 9), substance use and abuse (n = 13), environmental aspects of infectious disease (n = 132), those affecting neonates and infants (n = 11), violence and injuries (n = 51), and miscellaneous (n = 9). Among the most important or prominent were studies of lead and arsenic toxicity at smelters, mercury in paint and beauty creams, dioxin in waste oil in Missouri, polychlorinated biphenyls and multiple other toxic chemicals, global pesticide poisoning outbreaks, hepatic angiosarcoma among vinyl chloride workers, toxic oil syndrome in Spain, eosinophilia-myalgia syndrome from contaminated L-tryptophan, diethylene glycol poisoning in Haiti, aflatoxicosis in Kenya, Gulf War illness among veterans, impact and needs assessments during natural disasters (e. Read More

    [Acute interstitial pneumonia: diagnostic approach and management].
    Rev Mal Respir 2011 Jun 14;28(6):809-22. Epub 2011 May 14.
    Service de pneumologie, hôpital Saint-Louis, université Denis-Diderot, AP-HP, Paris cedex 10, France.
    Acute interstitial pneumonia (AIP) encompasses a spectrum of pulmonary disorders characterized by involvement of the lung interstitium and distal airways (bronchioles and alveoli). The onset of respiratory symptoms is acute, most often within two weeks. Most AIP take place de novo, but sometimes represent an acute exacerbation of chronic lung disease. Read More

    Post-epidemic eosinophilia-myalgia syndrome associated with L-tryptophan.
    Arthritis Rheum 2011 Nov;63(11):3633-9
    Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
    Eosinophilia-myalgia syndrome (EMS) is characterized by subacute onset of myalgias and peripheral eosinophilia, followed by chronic neuropathy and skin induration. An epidemic of EMS in 1989 was linked to consumption of L-tryptophan that had originated from a single source. Following the ban by the Food and Drug Administration (FDA) on the sale of L-tryptophan, the incidence of EMS declined rapidly. Read More

    Churg-Strauss Syndrome following PTU Treatment.
    Int J Rheumatol 2009 8;2009:504105. Epub 2009 Mar 8.
    Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Centre Rotterdam, 3000 CA Rotterdam, The Netherlands.
    Propylthiouracil (PTU) is a frequently prescribed drug in the treatment of hyperthyroidism. The use of PTU is, however, accompanied by numerous potentially serious side effects including vasculitis. PTU-related vasculitides can present as haematuria, pulmonary haemorrhage, or cutaneous lesion together with aspecific symptoms such as fever, myalgia, arthralgia, and fatigue. Read More

    [Skin manifestations of toxic syndrome due to denatured rapeseed oil].
    Actas Dermosifiliogr 2009 Dec;100(10):857-60
    Servicio de Dermatología, Complejo Hospitalario Universitario de A Coruña, España.
    This article offered an extensive description of the clinical and pathological features and time-course of the skin manifestations of toxic syndrome caused by denatured rapeseed oil, also known as toxic oil syndrome. This new condition occurred in Spain in 1981 and was due to the ingestion of rapeseed oil intended for industrial use that had been denatured with anilines and subsequently refined and sold fraudulently as olive oil. In total, 20,000 cases and 400 deaths were reported. Read More

    AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome?
    Immunol Lett 2010 Feb 24;128(2):154-5. Epub 2009 Nov 24.
    The aryl-hydrocarbon-receptor (AHR) is involved as receptor and transcription factor in dioxin toxicity. Recently, its role in Th17-mediated autoimmunity and autoinflammation has been described, yet a disease-associated AHR ligand is still elusive. L-tryptophan and its metabolites are assumed to trigger the autoinflammatory disorders eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome. Read More

    Immunogenetic risk and protective factors for the development of L-tryptophan-associated eosinophilia-myalgia syndrome and associated symptoms.
    Arthritis Rheum 2009 Oct;61(10):1305-11
    Ichikawa General Hospital, Tokyo Dental College, Ichikawa, Japan.
    Objective: To assess L-tryptophan (LT) dose, age, sex, and immunogenetic markers as possible risk or protective factors for the development of LT-associated eosinophilia-myalgia syndrome (EMS) and related clinical findings.

    Methods: HLA-DRB1 and DQA1 allele typing and Gm/Km phenotyping were performed on a cohort of 94 white subjects with documented LT ingestion and standardized evaluations. Multivariate analyses compared LT dose, age, sex, and alleles among groups of subjects who ingested LT and subsequently developed surveillance criteria for EMS, developed EMS or characteristic features of EMS (EMS spectrum disorder), or developed no features of EMS (unaffected). Read More

    Churg-Strauss syndrome presenting as myositis following unaccustomed exercise.
    J Clin Neurosci 2009 Sep 3;16(9):1232-3. Epub 2009 Jun 3.
    Department of Neurology, Aizawa Hospital, 2-5-1 Honjo, Matsumoto 390-8510, Japan.
    A 68-year-old woman with a 4 year history of bronchial asthma developed marked myalgia in the extremities following exercise to which she was unaccustomed. Examination on admission, 11 days after onset, revealed myalgia, muscular weakness and cutaneous hemorrhagic bullae. Blood tests revealed eosinophilia (9160/mm(3)) and elevation of creatinine kinase and C-reactive protein. Read More

    Neuromuscular disorders associated with apical hypertrophic cardiomyopathy.
    Acta Cardiol 2009 Feb;64(1):85-9
    Krankenanstalt Rudolfstiftung, Vienna, Austria.
    Background: Cardiomyopathy is a frequent manifestation of neuromuscular disorders.

    Aims And Objectives: The aim of this study was to investigate how often apical hypertrophic cardiomyopathy (AHC) is associated with neuromuscular disorders (NMDs), which types of NMDs are associated with AHC, and if the outcome of patients with NMD and AHC is different from those with AHC but without a NMD.

    Method: Literature review by means of a Medline (PubMed) search for the terms AHC, apical hypertrophy, NMD, myopathy, muscular dystrophy, skeletal muscle, and cardiac involvement. Read More

    [Shulman's syndrome (eosinophilic fasciitis)].
    Hautarzt 2009 Apr;60(4):278-81
    Hautklinik, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225 Düsseldorf.
    Eosinophilic fasciitis is a rare disease characterized by edema, painful indurations, and progressive muscle weakness. Mainly the extremities are involved. We report on a 22-year-old woman with eosinophilic fasciitis presenting with progressive muscle weakness of both hands and feet and a reduced general condition. Read More

    Eosinophilic myositis in calpainopathy: could immunosuppression of the eosinophilic myositis alter the early natural course of the dystrophic disease?
    Neuromuscul Disord 2009 Apr 13;19(4):261-3. Epub 2009 Mar 13.
    Department of Neurology, Neuromuscular Unit, Istanbul University, Istanbul Medical Faculty, Capa, Istanbul 34390, Turkey.
    An 11-year-old girl with a calpain-3 gene (CAPN-3) mutation and eosinophilic myositis on muscle biopsy had high serum CK levels and eosinophil counts which showed spontaneous fluctuations. After commencement of immunosuppressive therapy reciprocal changes occurred in response to alterations in doses of the medications. Subacutely evolving and spreading muscle weakness developed during tapering of the immunosuppressive medications. Read More

    Review article toxic oil syndrome: review of immune aspects of the disease.
    J Immunotoxicol 2005 Jan;2(1):51-8
    Laboratory of Molecular Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina.
    In 1981-1982, individuals in fourteen central and northwest provinces in Spain were affected by an illness that was eventually labeled toxic oil syndrome (TOS) by the World Health Organization. Thousands of individuals were diagnosed with, and 356 people eventually died from, the disease. The disease shares striking similarities with several autoimmune diseases, particularly eosinophilia-myalgia syndrome (EMS) and diffuse fasciitis with eosinophilia (DFE). Read More

    [Current differential diagnosis of hypereosinophilic syndrome].
    Med Pregl 2007 Nov-Dec;60(11-12):581-6
    Klinika za hematologiju, Klinicki centar Vojvodine, Novi Sad.
    Introduction: Hypereosinophilic syndrome (HES) is a group of idiopathic disorders associated with single or multiple organ system dysfunction. HES must be distinguished from reactive eosinophilia in parasitic infections, allergic diseases, and especially from hematological diseases of clonal origin.

    Reactive Eosinophilia Due To Infectious And Parasitic Diseases: Tissue helminth infections, especially toxocariasis, cause severe and long-standing hypereosinophilia. Read More

    Activity of certain drugs in inducing of inflammatory myopathies with cutaneous manifestations.
    Expert Opin Drug Saf 2008 Jul;7(4):421-33
    University of Medicine, Department of Dermatology and Venereology, 1 St Georgi Sofiiski Street, 1431 Sofia, Bulgaria.
    Background: At present, the pharmacological activity of drugs in inducing of inflammatory myopathies is not a solved problem.

    Objective: Analysis of the adverse reaction of drugs show that in both adults and children they can cause clinical manifestations of dermatomyositis and its variants [classic, juvenile, paraneoplastic or amyopathic], polymyositis and its variants [eosinophilic myositis, overalp syndrome], or other conditions such as eosinophilia myalgia syndrome, and eosinophilic fasciitis.

    Methods: Literature databases were analyzed and combined with personal experience to identify drug activity associated with dermatomyositis and its variants. Read More

    Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats.
    Arzneimittelforschung 2008 ;58(5):225-41
    Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Germany.
    Fibrates are widely prescribed in hyperlpidemic patients to prevent atherosclerosis. Their therapeutic use, however, can be associated with adverse effects like gastrointestinal disorders, myalgia, myositis and hepatotoxicity. In rodents large doses can even cause hepatocellular carcinoma. Read More

    Scleroderma-like disorders.
    Autoimmun Rev 2008 Feb 11;7(4):331-9. Epub 2008 Jan 11.
    Rheumatology Unit, Azienda Ospedaliera Universitaria V. Emanuele, Ferrarotto, S. Bambino Catania, Italy.
    Fibrosing disorders comprise a wide spectrum of heterogeneous diseases characterized by sclerosis of the dermis, subcutis, and sometimes the underlying soft tissues and bone. The hallmark of this group of diseases is skin thickening as in systemic sclerosis with a different distribution pattern and for this reason they have also been referred to as "scleroderma-like" disorders. These diseases may have a different clinical course ranging from a benign disease with a localized cutaneous involvement, to a widespread, systemic, life-threatening disease. Read More

    [Acute respiratory failure as a manifestation of eosinophilia-myalgia syndrome associated with L-tryptophan intake].
    J Bras Pneumol 2007 Nov-Dec;33(6):747-51
    Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.
    Eosinophilia-myalgia syndrome was described in 1989 in patients who presented progressive and incapacitating myalgia and eosinophilia in blood, fluids and secretions. Most patients report previous L-tryptophan intake. Respiratory manifestations are found in up to 80% of the cases, occasionally as the only manifestation. Read More

    Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome.
    Chem Res Toxicol 2007 Oct 25;20(10):1556-62. Epub 2007 Sep 25.
    Department of Biological Organic Chemistry, Institut d'Investigacions Químiques i Ambientals de Barcelona, Spain.
    Eosinophilia-myalgia syndrome (EMS) was an intoxication episode that occurred in the US in 1989 and affected 1,500 people. EMS was associated with the ingestion of manufactured L-tryptophan, and 3-(N-phenylamino)alanine (PAA) was identified as one of the contaminants present in the L-tryptophan batches responsible for intoxication. In previous studies (Martínez-Cabot et al. Read More

    Strain-dependent acute lung injury after intra-tracheal administration of a 'refined' aniline-denatured rapeseed oil: a murine model of the toxic oil syndrome?
    Food Chem Toxicol 2007 Dec 4;45(12):2563-73. Epub 2007 Jul 4.
    Laboratory of Lung Toxicology, K.U. Leuven, Leuven, Belgium.
    Most attempts to reproduce the toxic oil syndrome in animals, either with case-related oils or with refined rapeseed oils, have been unsuccessful. An aniline-denatured rapeseed oil that was subsequently refined according to a protocol yielding relevant markers of "toxic oil" (oil RSO160401) had led to possibly relevant lesions following oral administration in mice. Therefore, in the present study, RSO160401 was subjected to a more extended in vivo testing. Read More

    [Diagnostic problems in eosinophilic fasciitis].
    Pol Arch Med Wewn 2006 Aug;116(2):777-80
    Katedra i Klinika Reumatologiczno-Rehabilitacyjna i Chorób Wewnetrznych AM.
    We presented two cases with symptoms of diffuse swelling of subcutaneous tissue, stiffness and tenderness of involved areas, fever, eosinophilia and hypergammaglobulinemia. The inflammatory infiltrates consisting of lymphocytes, plasma cells and eosinophils were yielded in fascia. The difficulties in differentition of the symptoms between eosinophilic fasciitis and "eosinophilia-myalgia syndrome" are discussed. Read More

    Katayama syndrome.
    Lancet Infect Dis 2007 Mar;7(3):218-24
    Department of Community Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
    Katayama syndrome is an early clinical manifestation of schistosomiasis that occurs several weeks post-infection with Schistosoma spp (trematode) worms. Because of this temporal delay and its non-specific presentation, it is the form of schistosomiasis most likely to be misdiagnosed by travel medicine physicians and infectious disease specialists in non-endemic countries. Katayama syndrome appears between 14-84 days after non-immune individuals are exposed to first schistosome infection or heavy reinfection. Read More

    Calcinosis cutis in a patient with eosinophilia-myalgia syndrome: case report.
    Cutis 2006 Jun;77(6):361-4
    Department of Dermatology, Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029, USA.
    Eosinophilia-myalgia syndrome (EMS) often is a disabling disorder caused by the consumption of contaminated L-tryptophan. Affected patients present with an array of symptoms, including cutaneous manifestations, peripheral eosinophilia, myalgias, and long-term neurocognitive disability. This article is the first reported case of a patient with EMS who developed calcinosis cutis. Read More

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