600 results match your criteria Eosinophilia-Myalgia Syndrome


Not just eosinophilic fasciitis.

J Med Life 2021 Jan-Mar;14(1):121-124

Department of Gastroenterology, Bucharest Emergency University Hospital.

This case report describes a rare case of progressive muscle weakness in a patient treated for eosinophilic fasciitis (EF) for many years before being diagnosed with a second autoimmune disease: dermatomyositis. Our case is a report of a 65-year-old male diagnosed with eosinophilic fasciitis 7 years before being evaluated in our service at Mayo Clinic in Jacksonville, Florida, due to progressive muscle weakness despite the chronic treatment with methotrexate. Contrast-enhanced magnetic resonance imaging of the lower extremity showed enhancement throughout the thigh musculature, which led us to pursue biopsies of the fascia and muscle in order to confirm the diagnosis of EF associated with myopathy. Read More

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Clinical perspective and practices on pleural effusions in chronic systemic inflammatory diseases.

Breathe (Sheff) 2020 Dec;16(4):200203

Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Systemic inflammatory diseases are a heterogeneous family of autoimmune chronic inflammatory disorders that affect multiple systems within the human body. Connective tissue disease (CTD) is a large group within this family characterised by immune-mediated inflammation of the connective tissue. This group of disorders are often associated with pleural manifestations. Read More

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December 2020

Chemical exposure-induced systemic fibrosing disorders: Novel insights into systemic sclerosis etiology and pathogenesis.

Semin Arthritis Rheum 2020 12 19;50(6):1226-1237. Epub 2020 Sep 19.

Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, United States.

Numerous drugs and chemical substances are capable of inducing exaggerated tissue fibrotic responses. The vast majority of these agents cause localized fibrotic tissue reactions or fibrosis confined to specific organs. Although much less frequent, chemically-induced systemic fibrotic disorders have been described, sometimes occurring as temporally confined outbreaks. Read More

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December 2020

Cerebral Infarction and Myalgia in a 75-year-old Man with Eosinophilic Granulomatosis with Polyangiitis.

Intern Med 2020 Dec 4;59(23):3089-3092. Epub 2020 Aug 4.

Department of Neurology, Tokyo Medical University, Japan.

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare condition of systemic vasculitis of small to medium-sized blood vessels. We herein report the case of a 75-year-old man who presented with hemiplegia on his right side due to cerebral infarction following myalgia and a high fever. He had no history of asthma or allergic rhinitis. Read More

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December 2020

Pharmacovigilance and drug-induced rare diseases: Strengths of the French Network of Regional Pharmacovigilance Centres.

Therapie 2020 Apr 13;75(2):207-213. Epub 2020 Feb 13.

Centre régional de pharmacovigilance et d'information sur le médicament, service de pharmacosurveillance, CHU de Tours, 37044 Tours, France. Electronic address:

The French-style organization in the field of rare diseases allows a close contact between reference centres and regional pharmacovigilance centres thanks to their implementation within the French university hospital. This collaboration leads to highlight more and more drug-induced rare diseases. Through several historical examples (eosinophilia-myalgia syndrome due to L-tryptophan, type 1 narcolepsy with H1N1 pandemic influenza vaccine, capillary leak syndrome, acquired von Willebrand syndrome), it remains clear that pharmacovigilance is the cornerstone of the alert system. Read More

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[Hypereosinophilic syndrome and other rheumatic diseases with hypereosinophilia].

Z Rheumatol 2019 May;78(4):322-332

Klinik für Innere Medizin I, Sektion Rheumatologie, Exzellenzzentrum Entzündungsmedizin, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Deutschland.

Among the eosinophilic diseases treated by rheumatologists other than eosinophilic granulomatosis with polyangiitis, there are further organ-related and systemic diseases with hypereosinophilia. Only the exact differential diagnostic demarcation of the diseases enables a pathogenetic oriented treatment. This article focuses on the hypereosinophilic syndromes. Read More

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Eosinophilic fasciitis associated with myositis: Report of four cases and review of the literature.

Australas J Dermatol 2019 Aug 27;60(3):e227-e231. Epub 2018 Dec 27.

Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.

Eosinophilic fasciitis is a rare scleroderma-like syndrome with an unknown aetiology. The characteristics of this disorder include lymphoplasmacytic inflammation involving the subcutaneous fat septa and fascia. Eosinophilic myositis is diagnosed when inflammation extends into the muscles. Read More

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Meglumine antimoniate-induced DRESS: original case with a positive skin test.

Acta Parasitol 2018 Dec;63(4):845-847

Department of Pharmacology, University of Medicine, Avenue Avicenne 5019 Monastir, Tunisia.

We report a case of a 64-year-old woman treated with meglumine antimoniate (Glucantime®). On day 20, she developed fever, a pruriginous skin rash and myalgia. The blood tests showed eosinophilia and hepatic cytolysis. Read More

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December 2018

Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome.

Toxicol Lett 2018 Sep 22;294:193-204. Epub 2018 May 22.

ReNeuroGen LLC, Milwaukee, WI, 53122, USA. Electronic address:

The eosinophilia-myalgia syndrome (EMS) outbreak that occurred in the USA and elsewhere in 1989 was caused by the ingestion of Showa Denko K.K. (SD) L-tryptophan (L-Trp). Read More

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September 2018

Atypical presentation of atypical haemolytic uraemic syndrome.

BMJ Case Rep 2018 Feb 11;2018. Epub 2018 Feb 11.

Department of Pediatrics, Stony Brook University Hospital, Stony Brook, New York, USA.

A 17-year-old girl presented with fever, myalgia, vomiting for 1 month and oliguria and dyspnoea for 4 days. She was tachycardic,hypertensive, with pedal oedema and decreased breath sounds. She had high serum creatinine (3 mg/dL), anaemia, thrombocytopenia, leucocytosis and eosinophilia with schistocytes. Read More

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February 2018

Structure determination of disease associated peak AAA from l-Tryptophan implicated in the eosinophilia-myalgia syndrome.

Toxicol Lett 2018 Jan 14;282:71-80. Epub 2017 Oct 14.

ReNeuroGen LLC, Milwaukee, WI 53122, USA. Electronic address:

The eosinophilia-myalgia syndrome (EMS) outbreak of 1989 that occurred in the USA and elsewhere was caused by the ingestion of l-Tryptophan (L-Trp) solely manufactured by the Japanese company Showa Denko K.K. (SD). Read More

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January 2018

Serpiginous Purpuric Eruption of the Leg.

J Drugs Dermatol 2017 Oct;16(10):1036-1038

A previously healthy 68-year-old male presented with a rash on his right lower leg. The lesions had spread along the leg since onset 9 days prior, and the patient reported localized soreness and pruritus. He denied systemic symptoms including fever, fatigue, myalgia, joint pain, and recent illness. Read More

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October 2017

Two Catastrophes in One Patient: Drug Reaction with Eosinophilia and Systemic Symptoms and Toxic Shock Syndrome.

Cureus 2017 Jun 15;9(6):e1359. Epub 2017 Jun 15.

Internal Medicine, Quillen College of Medicine at East Tennessee State University.

A 70-year-old, immunocompromised patient presented to the emergency room (ER) five weeks after she was started on clopidogrel. She complained of skin eruption, mouth ulcers, fatigue, and myalgia over the past two weeks. Labs showed severe hyponatremia, acute kidney injury, rhabdomyolysis, hyperkalemia, and elevated liver enzymes. Read More

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Possible Parkinson's Disease Induced by Chronic Manganese Supplement Ingestion.

Authors:
Michael J Schuh

Consult Pharm 2016 Dec;31(12):698-703

Objective: The objective is to report a case of possible neurotoxicity resulting from an incorrect dietary supplement for osteoporosis taken at a toxic dose.

Summary: The case study examined here is a 37-year-old African-American female who consumed excessive manganese over a period of years, resulting in Parkinson's disease (PD). This patient was referred to the pharmacist pharmacotherapy service by a neurology physician. Read More

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December 2016

Febuxostat-associated eosinophilic polymyositis in marginal zone lymphoma.

Joint Bone Spine 2017 Mar 7;84(2):221-223. Epub 2016 Dec 7.

Department of Rheumatology, Faculty of Medicine, Saint-Joseph university, Hotel-Dieu de France, Beirut, Lebanon.

Febuxostat is an orally administered selective inhibitor of xanthine oxidase approved for the treatment of gout and prevention of tumor lysis syndrome. It is a relatively safe medication. Hypersensitivity reactions associated with the use of febuxostat are quite rare with only one reported case of DRESS syndrome. Read More

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The Importance of Quality Specifications in Safety Assessments of Amino Acids: The Cases of l-Tryptophan and l-Citrulline.

J Nutr 2016 Dec 9;146(12):2643S-2651S. Epub 2016 Nov 9.

US Pharmacopeial Convention, Rockville, MD.

The increasing consumption of amino acids from a wide variety of sources, including dietary supplements, natural health products, medical foods, infant formulas, athletic and work-out products, herbal medicines, and other national and international categories of nutritional and functional food products, increases the exposure to amino acids to amounts far beyond those normally obtained from the diet, thereby necessitating appropriate and robust safety assessments of these ingredients. Safety assessments of amino acids, similar to all food constituents, largely rely on the establishment of an upper limit [Tolerable Upper Intake Level (UL)] considered to be a guide for avoiding high intake, above which adverse or toxic effects might occur. However, reliable ULs have been difficult or impossible to define for amino acids because of inadequate toxicity studies in animals and scarce or missing clinical data, as well as a paucity or absence of adverse event reporting data. Read More

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December 2016

[Eosinophilic fasciitis (Shulman's disease): Diagnostic and therapeutic review].

Authors:
D Sène

Rev Med Interne 2015 Nov 16;36(11):738-45. Epub 2015 Sep 16.

Université Paris-Cité Sorbonne Paris-Diderot, 75013 Paris, France; Service de médecine interne, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France. Electronic address:

Eosinophilic fasciitis (EF) is a rare connective tissue disease characterized by symmetrical and painful swelling with a progressive induration and thickening of the skin and soft tissues. The diagnosis of EF is often based on the association of characteristic skin or subcutaneous abnormalities and a thickened fascia with an inflammatory infiltration, mostly composed of lymphocytes and eosinophils. A peripheral eosinophilia is frequently present (60-90%) but is not mandatory for the EF diagnosis. Read More

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November 2015

Eosinophilia in Rheumatologic/Vascular Disorders.

Immunol Allergy Clin North Am 2015 Aug 17;35(3):453-76. Epub 2015 Jun 17.

Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, 9500 Euclid Avenue, A50, Cleveland, OH 44195, USA. Electronic address:

Peripheral and tissue eosinophilia can be a prominent feature of several unique rheumatologic and vascular diseases. These diseases span a wide range of clinical features, histologic findings, therapeutic approaches, and outcomes. Despite the rare nature of these entities--which makes large-scale studies challenging--knowledge has continued to grow regarding their epidemiology, pathophysiology, and management. Read More

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Prediction of drug-induced eosinophilia adverse effect by using SVM and naïve Bayesian approaches.

Med Biol Eng Comput 2016 Mar 5;54(2-3):361-9. Epub 2015 Jun 5.

College of Life Science, Northwest Normal University, Lanzhou, 730070, Gansu, People's Republic of China.

Drug-induced eosinophilia is a potentially life-threatening adverse effect; clinical manifestations, eosinophilia-myalgia syndrome, mainly include severe skin eruption, fever, hematologic abnormalities, and organ system dysfunction. Using experimental methods to evaluate drug-induced eosinophilia is very complicated, time-consuming, and costly in the early stage of drug development. Thus, in this investigation, we established computational prediction models of drug-induced eosinophilia using SVM and naïve Bayesian approaches. Read More

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Muscle pain, fever, cough, and progressive dyspnea in a woman with eosinophilic pneumonia.

Genet Mol Res 2015 Apr 28;14(2):4189-94. Epub 2015 Apr 28.

Respiratory Disease Department, Xinqiao Hospital, Third Military Medical University, Chongqing, China

The diagnosis of eosinophilic pneumonia (EP) is rare and challenging. This condition is frequently misdiagnosed as pulmonary tuberculosis, lymphoma, schistosomiasis, Wegener's granuloma, severe acute respiratory syndrome, or severe community-acquired pneumonia. Herein, we report a case in which computed tomography (CT)-guided percutaneous lung biopsy was used to diagnose EP without alveolar eosinophilia or peripheral eosinophilia. Read More

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[Eosinophilic fasciitis].

Postepy Hig Med Dosw (Online) 2015 Jan 2;69:488-95. Epub 2015 Jan 2.

Katedra i Klinika Reumatologii i Chorób Wewnętrznych Uniwersytetu Medycznego w Poznaniu.

Eosinophilic fasciitis is a rare connective tissue disease with unclear etiology and pathogenesis. It is classified as a scleroderma-like syndrome. The disease is characterized by fibrosis of the skin and subcutaneous tissues with significant thickening of fascia. Read More

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January 2015

Vasculitis secondary to anti-C1q antibodies induced by Toxocariasis.

Infection 2015 Dec 26;43(6):755-8. Epub 2015 Mar 26.

Department of Internal Medicine, Caen University Hospital, Caen, France.

Introduction: Vasculitides occurring during parasitic infection are rare and may imply different mechanisms.

Methods: A case report of cutaneous vasculitis and visceral damage during a larva migrans syndrome.

Results: We report the case of a 64-year-old man who developed a purpura along with fever, respiratory failure, abdominal pain and myalgia. Read More

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December 2015

Association of eosinophilic fasciitis with morphea.

Folia Med (Plovdiv) 2014 Jul-Sep;56(3):220-4

Department of Dermatology and Venereology, Faculty of Medicine, Medical University, Plovdiv

Eosinophilic fasciitis is a rare inflammatory disease of unknown etiology, described for the first time by Shulman in 1974. The disease presents with induration of the skin, connective tissue and the underlying muscle fascia, sometimes accompanied by myalgia, most commonly in the lower extremities. Unlike scleroderma, it presents with absence of visceral organ involvement and Raynaud's phenomenon. Read More

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January 2015

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) presenting as diffuse myositis.

BMC Musculoskelet Disord 2014 Nov 21;15:388. Epub 2014 Nov 21.

Department of Internal Medicine, Université de Sherbrooke, 3001 12e Avenue, Fleurimont, QC J1H 5N4, Canada.

Background: Eosinophilic granulomatosis with polyangiitis is a complex multisystemic syndrome with heterogeneous presentation. Most often, there is a clinical history of asthma or other atopic conditions, and current presentation generally includes signs of cutaneous or pulmonary involvement. Very few reports described myalgia or weakness as the chief complaint. Read More

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November 2014

Clinical & biochemical profile of trichinellosis outbreak in north India.

Indian J Med Res 2014 Sep;140(3):414-9

Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.

Background & Objectives: Trichinellosis is a parasitic infection caused by Trichinella nematodes, acquired from consumption of raw meat. However, data from Indian subcontinent are limited. The aim of this study was to investigate the clinical and biochemical profile of a suspected trichinellosis outbreak in a village in Tehri Garhwal district of Uttarakhand state in north India. Read More

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September 2014

Acute painful paraplegia in a 49-year-old man with allergic asthma.

BMJ Case Rep 2014 Jun 30;2014. Epub 2014 Jun 30.

Division of Pulmonology, S Anna Hospital, San Fermo della Battaglia (CO), Italy.

We present a case of a 49-year-old man, with a 10-year history of bronchial asthma and nasal polyposis, who developed acutely painful paraplegia and paresthesias. Laboratory data showed elevated blood creatine kinase levels and myoglobinuria, which were diagnostic for rhabdomyolysis but only partially explained the neurological deficit. Electrophysiological studies revealed a sensorimotor neuropathy of multiple mononeuritis type. Read More

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Idiopathic eosinophilic cholecystitis with cholelithiasis: a report of two cases.

Turk Patoloji Derg 2014 ;30(2):142-4

Department of Pathology, Lady Hardinge Medical College, NEW DELHI, INDIA.

Eosinophilic cholecystitis is a rare entity diagnosed on the basis of classical presentation of cholecystitis with presence of more than 90% eosinophilic infiltration within the gall bladder. The etiology of eosinophilic cholecystitis still remains obscure. However it is frequently associated with other more severe diseases like hypereosinophilic syndrome, eosinophilic-myalgia syndrome, parasitic infestations, few herbal medicines and certain drugs. Read More

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Diagnosis and classification of eosinophilic fasciitis.

Autoimmun Rev 2014 Apr-May;13(4-5):379-82. Epub 2014 Jan 11.

Muscle Research Unit, Internal Medicine Service, Hospital Clínic de Barcelona, Villarroel 170, 08036 Barcelona, Spain; Fundació Cellex, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain. Electronic address:

Eosinophilic fasciitis (EF) is a rare scleroderma-like syndrome with an unknown etiology and pathogenesis that should be considered an immune-allergic disorder. Painful swelling with progressive induration and thickening of the skin and soft tissues of the limbs and trunk are the clinical hallmarks of the disease. Peripheral blood eosinophilia, hypergammaglobulinemia, and elevated erythrocyte sedimentation rate are the main laboratory findings. Read More

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Immunohistochemical studies of the kynurenine pathway in morphea.

Int J Tryptophan Res 2013 23;6:97-102. Epub 2013 Dec 23.

Zenith Specialist Pathology, South Brisbane, Queensland, Australia.

Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, skin biopsies were taken from involved and non-involved sites in a series of three patients with morphea. Immunohistochemical stains for quinolinic acid and indoleamine 2,3-dioxygenase (IDO) were performed. Read More

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January 2014

Eosinophilia-myalgia syndrome induced by excessive L-tryptophan intake from cashew nuts.

Cent Eur J Med 2014 16;9(6):796-801. Epub 2014 Aug 16.

1University Hospital Center Zagreb, 10000 Zagreb, Croatia.

Eosinophilia is characterized by more than 0.5 × 10 eosinophils per liter in the full blood count. A wide range of conditions, from asthma to parasitic infections, autoimmune diseases, and certain forms of cancer, have been known to trigger abnormally high amount of eosinophils. Read More

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