32,825 results match your criteria Eosinophilia


HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms.

J Allergy Clin Immunol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA, 37232; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, AUS, 6150; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA, 37232; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA, 37232. Electronic address:

Background: Vancomycin is a prevalent cause of the severe hypersensitivity syndrome drug reaction with eosinophilia and systemic symptoms (DRESS) which leads to significant morbidity and mortality and commonly occurs in the setting of combination antibiotic therapy which impacts future treatment choices. Variations in human leukocyte antigen (HLA) class I in particular have been associated with serious T-cell mediated adverse drug reactions which has led to preventive screening strategies for some drugs.

Objective: To determine if variation in the HLA region is associated with vancomycin-induced DRESS. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749193021
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2019.01.045DOI Listing
February 2019
3 Reads

A Myelodysplastic Syndrome with Concurrent Basophilia and Eosinophilia Lacking Oncogenic Mutations in 54 Relevant Genes.

Clin Lab 2019 Jan;65(1)

Myelodysplastic syndromes (MDS) with basophilia or eosinophilia are very rare and portend poor prognoses. We present a rare patient who had MDS with excess blasts as well as peripheral basophilia and concurrent bone marrow (BM) basophilia/eosinophilia. She had a complex karyotype including 5q and 7q deletions; however, no oncogenic mutations were observed on next-generation sequencing of 54 genes known to be frequently mutated in acute myeloid leukemia/MDS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7754/Clin.Lab.2018.180729DOI Listing
January 2019

Non-malignant respiratory disease among workers in the rubber manufacturing industry: A systematic review and meta-analysis.

Am J Ind Med 2019 Feb 18. Epub 2019 Feb 18.

Respiratory Health Division, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Morgantown, West Virginia.

Background: Non-malignant respiratory disease (NMRD) cases have occurred among rubber manufacturing workers. We examined exposure to rubber manufacturing emissions as a risk factor for NMRD.

Methods: From a systematic literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (strong, intermediate, non-significant positive association, none) between exposure to rubber manufacturing emissions and NMRD-related morbidity and mortality, and conducted two meta-analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajim.22959DOI Listing
February 2019

Use of Emergency Department Extracorporeal Membrane Oxygenation for Treatment of Acute Necrotizing Myocarditis.

Clin Pract Cases Emerg Med 2019 Feb 4;3(1):47-50. Epub 2019 Jan 4.

University of Rochester Medical Center, Department of Emergency Medicine, Rochester, New York.

We report a case of acute necrotizing eosinophilic myocarditis (ANEM) secondary to drug rash with eosinophilia and systemic symptoms (DRESS) related to administration of minocycline. Myocarditis is a rare complication of DRESS and can manifest as either a self-limited hypersensitivity myocarditis or as the frequently fatal ANEM. Due to the high morbidity and mortality caused by this disease, emergency physicians should be aware of the potential of ANEM in patients with history of DRESS and new-onset cardiac dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5811/cpcem.2018.11.40569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366373PMC
February 2019

Bullous Pemphigoid with Atypical Skin Lesions and Acute Interstitial Nephritis: A Case Report and Focused Literature Review.

Am J Case Rep 2019 Feb 18;20:212-218. Epub 2019 Feb 18.

Department of Internal Medicine, Mount Sinai Hospital, Chicago, IL, USA.

BACKGROUND The hallmark of bullous pemphigoid (BP) is widespread tense blisters arising on normal or erythematous skin, often with marked pruritus, the diagnosis of which is confirmed by direct immunofluorescence (DIF). BP is an autoimmune process that can be induced, though rarely, by medications. Drug-induced BP often has atypical clinical presentation, which requires a good understanding of other dermatological conditions with similar presentations, in particular, bullous subtype of erythema multiforme. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/AJCR.911422DOI Listing
February 2019

Nested case-control study investigating the diagnostic role of tissue eosinophilia in adverse cutaneous drug reactions.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Although tissue-eosinophilia has traditionally been considered diagnostically supportive of adverse cutaneous drug reactions (ACDRs), studies have suggested it is neither a sensitive nor a specific finding in drug eruptions (DEs).

Objectives: Determining whether skin-tissue eosinophilia is a reliable indicator of ACDR.

Methods: A nested case-control retrospective study conducted in a cohort of 170 patients at a single institution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15509DOI Listing
February 2019

Allergic bronchopulmonary aspergillosis presumably unmasked by PD-1 inhibition.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Pulmonary and Critical Care, Tower Health System, West Reading, Pennsylvania, USA.

Programmed cell death-1 (PD-1) inhibitors stimulate immune recognition of tumour cells in cancer patients, but have significant autoimmune side effects including pneumonitis. We report the case of a patient with asthma and mild eosinophilia who developed unusual pulmonary side effect of bronchiectasis, severe eosinophilia (absolute eosinophil count: 3200 c/mm) and elevated IgE levels (7050 IU/mL; normal: <164 IU/mL) 4 months into therapy with the PD-1 inhibitor pembrolizumab. Aspergillus fumigatus IgG was elevated at 15. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-227814DOI Listing
February 2019

Eosinophilic Upper Airway Inflammation in a Murine Model Using an Adoptive Transfer System Induces Hyposmia and Epithelial Layer Injury with Convex Lesions.

Med Sci (Basel) 2019 Feb 5;7(2). Epub 2019 Feb 5.

Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a refractory upper airway disease, accompanied mainly by eosinophilia and/or asthma. In addition, the disease correlates with a high rate of hyposmia, following a marked infiltration of eosinophils into the inflamed site, the paranasal sinus. Although eosinophils are known to contribute to the development of hyposmia and CRSwNP pathology, the underlying mechanisms remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medsci7020022DOI Listing
February 2019

Drug Rash with Eosinophilia and Systemic Symptoms Syndrome Presenting After the Initiation of Staphylococcus hominis Infectious Endocarditis Treatment: A Case Report and Updated Review of Management Considerations.

Cureus 2018 Dec 4;10(12):e3679. Epub 2018 Dec 4.

Internal Medicine, University of Central Florida College of Medicine, Orlando, USA.

We present the case of a 62-year-old Caucasian man who was being treated for mitral valve endocarditis via a six-week course of vancomycin. On Day 32 of the treatment, he developed an erythematous, pruritic, desquamating, and painful rash covering 80% of the total body surface area and intermittent fevers. Laboratory findings included leukocytosis with peripheral blood eosinophilia and elevated erythrocyte sedimentation rate, C-reactive protein, and serum creatinine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367119PMC
December 2018
2 Reads

DP antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment.

Sci Transl Med 2019 Feb;11(479)

University of Leicester, Leicester LE3 9QP, UK.

Increased airway smooth muscle mass, a feature of airway remodeling in asthma, is the strongest predictor of airflow limitation and contributes to asthma-associated morbidity and mortality. No current drug therapy for asthma is known to affect airway smooth muscle mass. Although there is increasing evidence that prostaglandin D type 2 receptor (DP) is expressed in airway structural and inflammatory cells, few studies have addressed the expression and function of DP in airway smooth muscle cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aao6451DOI Listing
February 2019

Hemoptysis in the Immunocompromised Patient: Do Not Forget Strongyloidiasis.

Trop Med Infect Dis 2019 Feb 12;4(1). Epub 2019 Feb 12.

Department of Medicine, Division of Infectious Diseases, University of Texas Health, San Antonio, TX 78229, USA.

Strongyloidiasis, due to infection with the nematode , affects millions of people in the tropics and subtropics. has a unique auto-infective lifecycle such that it can persist in the human host for decades. In immunosuppressed patients, especially those on corticosteroids, potentially fatal disseminated strongyloidiasis can occur, often with concurrent secondary infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/tropicalmed4010035DOI Listing
February 2019

Human trichinellosis caused by Trichinella britovi in Greece, and literature review.

J Helminthol 2019 Feb 13:1-4. Epub 2019 Feb 13.

Department of Infectious Diseases, Istituto Superiore di Sanità,Rome,Italy.

Trichinellosis is a cosmopolitan zoonotic parasitic disease caused by the nematodes of the genus Trichinella, through the consumption of raw or semi-raw infected meat from swine, horses and wild animals. This disease has been sporadically reported in Greece since 1946. The aim of the present study was to describe a trichinellosis case in a patient hospitalized in northern Greece, in 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0022149X19000075DOI Listing
February 2019

An Unusual Case of Tricuspid Stenosis.

Eur J Case Rep Intern Med 2018 24;5(4):000836. Epub 2018 Apr 24.

Internal Medicine Department, Centro Hospitalar de São João, Porto, Portugal.

Tricuspid stenosis is an uncommon valvular abnormality commonly associated with other valvular lesions. Ebstein's anomaly is a rare congenital heart malformation characterized primarily by abnormalities of the tricuspid valve and right ventricle. Endomyocardial fibrosis is a restrictive cardiomyopathy observed in tropical and subtropical regions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2018_000836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346752PMC

Portal Vein Thrombosis and Thrombocytopenia in Eosinophilic Granulomatosis with Polyangiitis: A Paradox?

Eur J Case Rep Intern Med 2018 28;5(11):000971. Epub 2018 Nov 28.

Division of Rheumatology, Emek Medical Center, Itzhak Rabin Blvd., Afula, Israel.

A 36-year-old woman with eosinophilic granulomatosis with polyangiitis (EGPA) presented with necrotic skin lesions and pulmonary infiltrates. There was eosinophilic vasculitis on skin biopsy, and substantial tissue eosinophilia in her bone marrow. She had unexplained worsening thrombocytopenia, which prompted a thrombophilia work-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2018_000971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346807PMC
November 2018

Evaluation of Duodenal Eosinophil Count in Adult Patients with Functional Dyspepsia.

Mymensingh Med J 2019 Jan;28(1):150-156

Dr Md Abdul Mumit Sarkar, Resident, Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Several mechanisms have been proposed to explain the symptoms of functional dyspepsia but actual pathogenesis is still poorly understood. Recent studies support duodenal abnormality to be the most important causal link to explain symptoms and to understand abnormal pathophysiology of functional dyspepsia. The aim of this prospective observational study is to compare eosinophil count in duodenal mucosa between patients with functional dyspepsia and control subjects without dyspepsia and was done at the department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from December 2015 to December 2016. Read More

View Article

Download full-text PDF

Source
January 2019

Accuracy of renal tumour biopsy for the diagnosis and subtyping of papillary renal cell carcinoma: analysis of paired biopsy and nephrectomy specimens with focus on discordant cases.

J Clin Pathol 2019 Feb 12. Epub 2019 Feb 12.

Department of Pathology, University Health Network, Toronto, Ontario, Canada.

Aims: Renal tumour biopsy (RTB) is increasingly recognised as a useful diagnostic tool in the management of small renal masses, particularly those that are incidentally found. Intratumoural heterogeneity with respect to morphology, grade and molecular features represents a frequently identified limitation to the use of RTB. While previous studies have evaluated pathological correlation between RTB and nephrectomy, no studies to date have focused specifically on the role of RTB for the diagnosis of papillary renal cell carcinoma (PRCC) and its further subclassification into clinically relevant subtypes. Read More

View Article

Download full-text PDF

Source
http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2018-205655
Publisher Site
http://dx.doi.org/10.1136/jclinpath-2018-205655DOI Listing
February 2019
3 Reads

Survivin induces defects in apoptosis in eosinophils in intestine with food allergy.

Innate Immun 2019 Feb 12:1753425919829554. Epub 2019 Feb 12.

3 Research Center of Allergy & Immunology, Shenzhen University School of Medicine, China.

Survivin is an anti-apoptosis protein that may be associated with the development of eosinophilia; the latter is associated with the pathogenesis of many immune disorders. Here we report that less apoptotic eosinophils (Eos) were induced in those isolated from mice suffering from food allergy (FA) than those from naive mice after treating with cisplatin in vitro. Exposure to cisplatin induced more Fas ligand (FasL) expression in Eos isolated from naive mice than in those of FA mouse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1753425919829554DOI Listing
February 2019

Excessive periostin expression and Th2 response in patients with nasal polyps: association with asthma.

J Thorac Dis 2018 Dec;10(12):6585-6597

Otorhinolaryngology Hospital, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

Background: Periostin has been shown to be upregulated in chronic rhinosinusitis with nasal polyps (CRSwNP), especially in the CRSwNP patients with asthma. However, the underlying mechanism that how periostin contributes to the polyp genesis remains unclear.

Methods: In this study, we collected 63 CRSwNP patients' nasal polyps (NPs) and 25 control subjects' uncinated tissues. Read More

View Article

Download full-text PDF

Source
http://jtd.amegroups.com/article/view/25404/19441
Publisher Site
http://dx.doi.org/10.21037/jtd.2018.11.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344679PMC
December 2018
2 Reads

Evaluation of Peripheral Blood Eosinophilia in Adolescent and Adult Patients Suffering from Atopic Dermatitis and the Relation to the Occurrence of Allergy to Aeroallergens.

Indian J Dermatol 2019 Jan-Feb;64(1):34-40

Department of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic.

Background: Eosinophils play an important pathogenic role in atopic dermatitis (AD), but its exact function remains to be determined.

Aims And Objectives: The aim of this study was to correlate the eosinophil count with the manifestations such as asthma bronchiale, rhinitis, level of total IgE, sensitization to mites, animal dander, bird feather, dust, mixture of grass, mixture of trees, mixture of fungi, duration of lesions (persistent or occasional during last year), family history about atopy, and onset of AD (under or above 5 year of age).

Materials And Methods: Two hundred and seventy-two patients suffering from AD at the age of 14 year or older were examined - 100 men and 172 women with the average age of 26. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijd.IJD_509_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340239PMC
February 2019
1 Read

Eosinophil Peroxidase, GATA3 and T-bet as Tissue Biomarkers in Chronic Rhinosinusitis.

J Allergy Clin Immunol 2019 Feb 7. Epub 2019 Feb 7.

Department of Otolaryngology, Mayo Clinic, Phoenix, AZ; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic, Scottsdale, AZ; Division of Pulmonology, Phoenix Children's Hospital, Phoenix, AZ. Electronic address:

Eosinophil peroxidase is a potential biomarker for eosinophilic chronic rhinosinusitis. Th2/Th1 polarization, as measured by GATA3 and T-bet, was not associated with eosinophilia or any clinical or histopathologic feature of chronic rhinosinusitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.01.038DOI Listing
February 2019
1 Read

Abnormal T-cell phenotype in episodic angioedema with hypereosinophilia (Gleich's syndrome): frequency, clinical implication and prognosis.

J Am Acad Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Service de Médecine Interne, Université Versailles Saint-Quentin-en-Yvelines, Centre de Référence des Syndromes Hyperéosinophiliques (CEREO), Hôpital Foch, Suresnes, France.

Background: Episodic Angioedema with eosinophilia (EAE, Gleich's syndrome) is a rare disorder consisting of recurrent episodes of angioedema, hypereosinophilia and frequent elevated serum Immunoglobin M.

Methods: We conducted a retrospective multicenter nationwide study regarding the clinical spectrum and therapeutic management of patients with EAE in France.

Results: Thirty patients were included with a median age at diagnosis of 41 years [5-84]. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2019.02.001DOI Listing
February 2019
3 Reads

Vancomycin-associated Drug-Induced Hypersensitivity Syndrome (DIHS).

J Am Acad Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, University of California, San Francisco, San Francisco, CA. Electronic address:

Background: While hypersensitivity reactions are well-characterized for certain medications, vancomycin-associated drug-induced hypersensitivity syndrome (DIHS), or drug reaction with eosinophilia and systemic symptoms (DRESS), has yet to be defined.

Objective: To better define the clinical phenotype of vancomycin-associated DIHS.

Methods: A retrospective case series was conducted over an 8-year period at a single, academic institution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2019.02.002DOI Listing
February 2019
1 Read

Increased type 2 innate lymphoid cells in patients with drug reaction with eosinophilia and systemic symptom.

J Invest Dermatol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei and Keelung, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taiwan; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan. Electronic address:

Drug reaction with eosinophilia and systemic symptom (DRESS) is life-threatening disorder with an estimated mortality of 2%. Recently, type II innate lymphoid cells (ILC2s) has been implicated as an important contributor to the pathogenesis of allergic disorders. However, whether the roles of ILC2s and ILC2-associated cytokines in DRESS remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2018.10.048DOI Listing
February 2019
1 Read
7.216 Impact Factor

Eosinophil-derived IL-13 Promotes Emphysema.

Eur Respir J 2019 Feb 6. Epub 2019 Feb 6.

Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona, USA

The inflammatory responses in chronic airway diseases leading to emphysema are not fully defined. We hypothesised that lung eosinophilia contributes to airspace enlargement in a mouse model, and emphysema in patients with COPD.A transgenic mouse model of chronic type 2 pulmonary inflammation ( ) was used to examine eosinophil-dependent mechanisms leading to airspace enlargement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01291-2018DOI Listing
February 2019
1 Read

Sustained Response to Imatinib in a Pediatric Patient with Concurrent Myeloproliferative Disease and Lymphoblastic Lymphoma Associated with a CCDC88C-PDGFRB Fusion Gene.

Acta Haematol 2019 Feb 6;141(2):119-127. Epub 2019 Feb 6.

Department of Pediatric Hematology-Oncology, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel.

Background: The WHO defined myeloid and lymphoid neoplasms (MLN) with eosinophilia associated with PDGFRB, PDGFRA, FGFR1 rearrangements as a new entity in 2016. PDGFRB-rearranged MLN sensitive to imatinib were described in adult patients. We report the first pediatric patient with PDGFRB-rearranged myeloproliferative disorder associated with T-lymphoblastic lymphoma bearing the t(5; 14)(q33;q32) translocation who was successfully treated with imatinib only. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495687DOI Listing
February 2019
2 Reads

Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials: Bridging Clinical and Patient Perspectives.

Am J Respir Crit Care Med 2019 Feb 6. Epub 2019 Feb 6.

University of Wisconsin, Medicine, Madison, Wisconsin, United States.

Severe asthma affects a small proportion of asthma patients (~ 3-5%) and reflects a failure of conventional asthma medications to provide adequate control. Severe asthma is a disease of significant clinical heterogeneity, likely caused by different pathobiological mechanisms, frequently referred to as endotypes. In the last decade, multiple monoclonal therapies have been developed to target airway type-2 eosinophilic and/or allergic severe asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201809-1817PPDOI Listing
February 2019
2 Reads

Protection against Staphylococcus aureus bacteremia-induced mortality depends on ILC2s and eosinophils.

JCI Insight 2019 Feb 5. Epub 2019 Feb 5.

The dysregulated, unbalanced immune response of sepsis results in a mortality exceeding 20%, yet recent findings by our group indicate that patients with allergic, type 2-mediated immune diseases are protected from developing sepsis. We evaluated CD4+ T helper (Th) cell polarization among patients with Staphylococcus aureus bacteremia and confirmed that survivors had a higher percentage of circulating Th2 cells, but lower frequencies of Th17 cells and neutrophils early in the course of infection. To establish the mechanism of this protection, we employed a mouse model of lethal S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.124168DOI Listing
February 2019
1 Read

Filarial tropical pulmonary eosinophilia.

J Asthma 2019 Feb 5. Epub 2019 Feb 5.

b Dr DY Patil University , Pune , India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02770903.2018.1561892DOI Listing
February 2019
2 Reads

[Unexpected death due to eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)].

An Sist Sanit Navar 2019 Feb 5;0(0):67385. Epub 2019 Feb 5.

.

Eosinophilic granulomatosis with polyangiitis (EGPA), or Churg-Strauss syndrome, is a rare disease characterized by disseminated necrotizing vasculitis with extravascular granulomas occurring among patients with asthma and tissue eosinophilia. Clinically, it presents in various ways and progresses in three phases: prodromic (asthma and rhino-sinusitis), eosinophilic (peripheral eosinophilia and organ involvement), and vasculitic (clinical manifestations due to small vessel vasculitis). The differential diagnosis of EGPA principally includes eosinophilic and vasculitic disorders, early treatment is needed to avoid a fatal outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23938/ASSN.0395DOI Listing
February 2019
1 Read

Differential Diagnosis of Churg-Strauss Syndrome with Tingling Sensation and Weakness of the Lower Extremities.

Anesth Pain Med 2018 Dec 28;8(6):e84179. Epub 2018 Nov 28.

Department of Internal Medicine, Division of Rheumatology, Jeju National University Hospital, Jeju, Korea.

Introduction: Churg-Strauss syndrome (CSS; or eosinophilic granulomatosis with polyangiitis) is an extremely rare autoimmune condition characterized by hypereosinophilia and vasculitis of small or medium-sized blood vessels, occurring in patients with asthma and allergic rhinitis.

Case Presentation: A 47-year-old man (height, 175.8 cm and weight, 74. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5812/aapm.84179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347737PMC
December 2018
1 Read

Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis.

J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan.

The role of eosinophil in systemic sclerosis (SSc) is still controversial. In the present study, the relationship between skin ulcers and peripheral blood eosinophilia were analyzed in patients with SSc. We retrospectively investigated the clinical records of all patients who were diagnosed with SSc on the basis of American College of Rheumatology/European League Against Rheumatism 2013 criteria, and were followed up for more than 2 years at Wakayama Medical University. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14774DOI Listing
February 2019
1 Read

Clinical and laboratory characterizations of hepatic capillariasis.

Acta Trop 2019 Jan 30. Epub 2019 Jan 30.

Beijing Institute of Tropical Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, PR China; Beijing Key Laboratory for Research on Prevention and Treatment of Tropical Diseases, Beijing, 100050, PR China. Electronic address:

Hepatic capillariasis is a rare and neglected parasitic disease caused by infection with Capillaria hepatica in human liver. The disease is not well described and the information for the disease's clinical manifestation, laboratory findings and disease management strategy is not well reported. The limited information for this neglected infection often results in the delay of diagnosis or misdiagnosed to other diseases, therefore the real prevalence or severity of the infection may be underestimated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actatropica.2019.01.023DOI Listing
January 2019
1 Read

Goblet Cell Hyperplasia as a feature of neutrophilic asthma.

Clin Exp Allergy 2019 Feb 1. Epub 2019 Feb 1.

Aix Marseille University, Inserm, INRA, C2VN, Marseille, France.

Background: Goblet Cell Hyperplasia (GCH) is a pathological finding classically reported across asthma severity levels and usually associated with smoking. Multiple biological mechanisms may contribute to excessive mucus production.

Objective: We aimed to decipher the clinical meanings and biological pathways related to GCH in non smokers with asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cea.13359DOI Listing
February 2019
1 Read

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome induced by imatinib.

Curr Drug Saf 2019 Jan 30. Epub 2019 Jan 30.

National Center Chalbi Belkahia of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis.. Tunisia.

Imatinib is the treatment of choice in patients with locally advanced or metastatic gastrointestinal stromal tumours (GIST). Clinical tolerance of imatinib is excellent except the common adverse drug reaction (ADR). Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a severe, potentially life-threatening drug-induced hypersensitivity reaction, characterized by cutaneous eruptions, fever, diffuse lymphadenopathy, along with eosinophilia, and elevated liver function tests. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/169478/article
Publisher Site
http://dx.doi.org/10.2174/1574886314666190130150243DOI Listing
January 2019
5 Reads

IgG4-related disease: what a hematologist needs to know.

Haematologica 2019 Jan 31. Epub 2019 Jan 31.

Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, Canada.

IgG4-related disease is a fibroinflammatory condition that can affect nearly any organ system. Common presentations include major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal fibrosis and tubulointerstitial nephritis. This review focuses on the hematological manifestations of IgG4-related disease, including lymphadenopathy, eosinophilia, and polyclonal hypergammaglobulinemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2018.205526DOI Listing
January 2019
2 Reads

Efficacy and tolerability of desensitization in the treatment of delayed drug hypersensitivities to anti-tuberculosis medications.

Respir Med 2019 Feb 9;147:44-50. Epub 2019 Jan 9.

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea. Electronic address:

Background: Delayed drug hypersensitivity to first-line anti-tuberculosis medication is a major challenge in tuberculosis treatment.

Objective: This study was performed to investigate the efficacy/tolerability of desensitization therapy in treatment of first-line anti-tuberculosis medication hypersensitivity and the usefulness of immunologic evaluation therein.

Methods: This study was conducted as a prospective, observational cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmed.2018.12.017DOI Listing
February 2019
1 Read
3.086 Impact Factor

Distinguishing tuberculosis pleural effusion from parasitic pleural effusion using pleural fluid characteristics: A case control study.

Medicine (Baltimore) 2019 Feb;98(5):e14238

Department of Pediatrics, West China Second Hospital, Sichuan University.

Tuberculosis pleural effusion (TPE) and parasitic pleural effusion (PPE) present with similar clinical manifestations. We evaluated the pleural fluid features of TPE and PPE.A total of 76 patients with pleuritis, including 25 patients with TPE and 51 patients with PPE were retrospectively studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014238DOI Listing
February 2019
2 Reads

Role of iron and oxidative stress in the exacerbation of allergic inflammation in murine lungs caused by urban particulate matter <2.5 μm and desert dust.

J Appl Toxicol 2019 Jan 30. Epub 2019 Jan 30.

Department of Environmental Toxicology, University of California, Davis, CA, 95616, USA.

Simultaneous exposure of lipopolysaccharide (LPS) and urban particulate matter <2.5 μm (PM2.5) or desert dust exacerbated murine asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3773DOI Listing
January 2019
1 Read

Incidental Pharmacogenetics Findings in an HLA-related Research: Considerations for Primary Prevention.

Clin Exp Allergy 2019 Jan 28. Epub 2019 Jan 28.

Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia.

Hypersensitivity drug reactions (HDRs) are an immense public health problem where significant proportions may lead to mortality. HDRs can manifest in various phenotypes, mainly cutaneous reactions that range from the mild; i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cea.13347DOI Listing
January 2019
8 Reads
4.769 Impact Factor

Angiolymphoid hyperplasia with eosinophilia: Two case reports.

Australas J Dermatol 2019 Jan 29. Epub 2019 Jan 29.

Department of Pathology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajd.12988DOI Listing
January 2019
2 Reads

Subcutaneous filariasis: An unusual presentation with an adult gravid worm on aspiration.

Trop Parasitol 2018 Jul-Dec;8(2):121-123. Epub 2018 Dec 27.

Department of Pathology, ESI Hospital, Rohini, Delhi, India.

Detection of adult gravid filarial worm in fine-needle aspiration cytology (FNAC) smears is unusual despite the high incidence of this parasite in endemic zones. Bancroftian filariasis presenting as subcutaneous nodules is very rare, and only a few cases are reported in literature. In spite of various reports stating the presence of microfilaria using aspiration cytology in various sites, the presence of an adult gravid filarial worm in subcutaneous nodules by FNAC is an extremely rare finding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/tp.TP_60_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329263PMC
December 2018
1 Read

Eosinophilic Meningitis: Report of Three Cases from a Hilly Area in Kerala.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):108-111

Department of Family Medicine, VPS Lakeshore Hospital, Kochi, Kerala, India.

Normal cerebrospinal fluid (CSF) does not contain eosinophils. The presence of >10 eosinophils/μL in CSF or at least 10% eosinophils in total CSF leukocyte count confirms eosinophilic meningitis. We present three patients with eosinophilic meningitis from the same locality with peripheral eosinophilia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aian.AIAN_254_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327688PMC
January 2019
1 Read

Increase of Eosinophil in Dialysate During Induction of Peritoneal Dialysis.

Perit Dial Int 2019 Jan-Feb;39(1):90-92

Nephrology, Nagoya University Postgraduate School of Medicine, Nagoya, Japan.

As a rare complication in patients on peritoneal dialysis (PD), increase of eosinophil (peritoneal dialysate fluid [PDF] eosinophilia), including eosinophilic peritonitis, was observed in PDF. The majority of eosinophilic peritonitis cases are detected during the early phase of PD induction. However, the frequency of and mechanisms underlying PDF eosinophilia remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3747/pdi.2017.00205DOI Listing
January 2019
1 Read

The Future of Asthma Care: Personalized Asthma Treatment.

Clin Chest Med 2019 Mar;40(1):227-241

Asthma UK, 18 Mansell Street, London E1 8AA, UK.

Although once considered a single disease entity, asthma is now known to be a complex inflammatory disease engaging a range of causal pathways. The most frequent forms of asthma are identified by sputum/blood eosinophilia and activation of type 2 inflammatory pathways involving interleukins-3, -4, -5, and granulocyte-macrophage colony-stimulating factor. The use of diagnostics that identify T2 engagement linked to the selective use of highly targeted biologics has opened up a new way of managing severe disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccm.2018.10.013DOI Listing
March 2019
2 Reads

Siglec-7 on peripheral blood eosinophils: surface expression and function.

Allergy 2019 Jan 28. Epub 2019 Jan 28.

Pharmacology& Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.

Background: Siglec-7 is an inhibitory receptor (IR) expressed on human blood eosinophils. Whereas activation of other IRs, including Siglec-8 and CD300a, has been shown to downregulate eosinophil function, little is known about the role of Siglec-7 on human eosinophils.

Objective: To examine Siglec-7 expression and function in eosinophils from normal (ND) and eosinophilic (EO) donors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.13730DOI Listing
January 2019

Histopathology of ethmoid mucosa versus polyp tissue in diagnosing eosinophilic mucin rhinosinusitis.

Rhinology 2019 Feb;57(1):67-72

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: This study aims to compare histopathology of nasal polyp and ethmoid mucosa for diagnosing eosinophilic mucin rhinosinusitis (EMRS).

Methodology: Patients with chronic rhinosinusitis with polyps (CRSwNP) were enrolled. Using eosinophilic mucin as a reference, histopathology of polyp apex, polyp pedicle and ethmoid mucosa was compared for density of tissue eosinophil and sensitivity for diagnosing EMRS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4193/Rhin18.068DOI Listing
February 2019
2 Reads

Severe Eosinophilia in Myelodysplastic Syndrome With a Defined and Rare Cytogenetic Abnormality.

Front Immunol 2018 9;9:3031. Epub 2019 Jan 9.

Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University Hospital, Osaka-Sayama, Japan.

Myelodysplastic syndromes (MDS) are a heterogeneous group clonal disorders of hematopoietic stem cells (HSC) characterized by ineffective hematopoiesis that lead to variable grades of impaired blood cell production. Chromosomal aberrations are often detected in MDS patients and thus cytogenetic analysis is useful for the diagnosis of these disorders. Common recurring chromosomal defects, such as the -5/5q- and -7/7q- are relatively well characterized cytogenetic abnormalities in MDS, however, the biological significance of uncommon cytogenetic alterations is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.03031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334338PMC
January 2019
1 Read