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Clin Exp Pediatr 2022 Jun 22. Epub 2022 Jun 22.

Division of Dermatology, King Chulalongkorn Memorial Hospital, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University , Bangkok, Thailand.

PLoS One 2022 27;17(6):e0268651. Epub 2022 Jun 27.

Division of Pediatric Allergy, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Charlestown, MA, United States of America.

The prevalence of allergic diseases is on the rise, yet the environmental factors that contribute to this increase are still being elucidated. Laundry detergent (LD) that contains cytotoxic ingredients including microbial enzymes continuously comes into contact with the skin starting in infancy. An impaired skin barrier has been suggested as a route of allergic sensitization. Read More

Ann Hematol 2022 Jun 27. Epub 2022 Jun 27.

Department of Hematology, The Affiliated People's Hospital of Ningbo University, 251 East Baizhang Road, Ningbo, 315000, Zhejiang, China.

J Zoo Wildl Med 2022 Jun;53(2):461-469

Zoo de Granby, Granby, QC J2G 5P3, Canada,

In this case series, clinical investigations were pursued during a infection in a lorikeet ( spp.) flock outbreak situation to better describe and document clinical presentations. In 11 lorikeets suspected to be infected with based on at least one abnormal finding on their physical examination (lethargy, feather-damaging behavior on the ventrum, weight loss, pale iris), the presence of five additional parameters was documented: anemia, relative eosinophilia, increased proventricular diameter-to-keel height ratio (PKR), proventricular barium filling defect, and positive fecal occult blood detection test. Read More

Immunology 2022 Jun 27. Epub 2022 Jun 27.

Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.

Type 2-high asthma is a chronic inflammatory disease of the airways which is increasingly prevalent in countries where helminth parasite infections are rare, and characterized by T helper 2 (Th2)-dependent accumulation of eosinophils in the lungs. Regulatory cytokines such as TGF-β can restrain inflammatory reactions, dampen allergic Th2 responses, and control eosinophil activation. The murine helminth parasite Heligmosomoides polygyrus releases a TGF-β mimic (Hp-TGM) that replicates the biological and functional properties of TGF-β despite bearing no structural similarity to the mammalian protein. Read More

IJID Reg 2022 Jun 24;3:135-137. Epub 2022 Mar 24.

Samaritan Surgical Centre, Addis Ababa, Ethiopia.

Background: Fascioliasis is a zoonotic infection caused by . (liver fluke). Although infrequently diagnosed, it is emerging as a helminth infection of public health importance in many parts of the world. Read More

J Immunol Res 2022 14;2022:7783481. Epub 2022 Jun 14.

Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai 200031, China.

To identify the effect of long noncoding RNA (lncRNA) FR215775 in regulating CD4+ T cells on murine models of allergic rhinitis (AR), the expression of lncRNA FR215775 in primary Th2 cells was detected through qRT-PCR. After knocking down the expression of lncRNA FR215775 via Sh-FR215775-Ads, Cell Counting Kit-8, cytometric bead array, and fluorescence-activated cell sorting were performed to determine its functions in vitro. Moreover, lncRNA FR215775-silencing or nonsilencing cells were injected intravenously into AR mice. Read More

Int J Appl Basic Med Res 2022 Apr-Jun;12(2):148-150. Epub 2022 May 10.

Department of Pharmacology, Dr. DY Patil Medical College, Navi Mumbai, Maharashtra, India.

Eosinophilic granulomatosis with polyangiitis also known as Churg-Strauss syndrome or allergic granulomatosis and angiitis is an extremely rare systemic necrotizing vasculitis that affects small-to-medium-sized vessels. Here, we report a case of a 58-year-old man presenting with painful swelling of bilateral lower limbs with multiple well-defined erosions on lower legs and dorsum of the foot with a few of them showing brownish crusts and with slight watery discharge and a few with raw areas. The patient is a known case of bronchial asthma. Read More

Pediatr Allergy Immunol 2022 Jun;33(6):e13815

MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):79-81

Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Strongyloides stercoralis causes chronic, mostly asymptomatic infections but hyperinfection syndrome may occur in immunosuppressed patients, especially in those receiving corticosteroids. We report a case of S. stercoralis hyperinfection syndrome in a solid organ transplant recipient that occurred approximately 2. Read More

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Shimotsuga, Tochigi, Japan.

Dermatol Clin 2022 Jul 2;40(3):265-277. Epub 2022 Jun 2.

Division of Pharmacovigilance, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

Postmarket surveillance is critical for the identification of rare safety risks, which are unlikely to be identified during clinical trials and the drug development program. Rare adverse drug reactions with the potential for serious outcomes, including fatalities, include the severe cutaneous adverse reactions of Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Dermatologists play an important role in the diagnosis of these serious drug reactions and contribute to drug safety by reporting cases of suspected cutaneous adverse drug reactions. Read More

Radiographics 2022 Jun 24:220004. Epub 2022 Jun 24.

From the Department of Radiology (M.Y., A.D.T.A., Z.S.K., M.L.W., J.P.H., S.P.S., J.L.F., S.K.V.) and Department of Laboratory Medicine and Pathology (M.S.T.), Mayo Clinic, 200 2nd St SW, Rochester, MN 55905; and Department of Diagnostic Imaging, National University Health System, Singapore (L.L.S.T.).

Eosinophilic gastrointestinal disorders (EGIDs) are inflammatory conditions of the gastrointestinal tract that are characterized by tissue eosinophilia and end-organ dysfunction or damage. Primary EGIDs are associated with atopy and other allergic conditions, whereas secondary EGIDs are associated with underlying systemic diseases or hypereosinophilic syndrome. Within the spectrum of EGIDs, eosinophilic esophagitis is the most prevalent. Read More

Front Oncol 2022 7;12:887945. Epub 2022 Jun 7.

National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Chronic eosinophilic leukemia not otherwise specified (CEL-NOS) is classified as Myeloproliterative Neoplasms (MPN) and refers to chronic eosinophilic leukemia with some atypical recurrent genetic evidence(1). A rare fusion of - was previously identified in patients with the t(5;12) (q31; p13) karyotype(2). Here, we report a case of CEL-NOS with a translocation of t(5;12) (q31; p13) and identify transcription, which has not been identified in hematologic diseases. Read More

J Immunol Res 2022 14;2022:2273121. Epub 2022 Jun 14.

Department of Otolaryngology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

The pathogenesis of CRSwNP is complex and unclear. CRSwNP is subdivided into two types based on the infiltration of EOSs: eCRSwNP and noeCRSwNP. This study was designed to seek the role of autophagy, mitophagy, and Akt/mTOR pathway in these two subtypes of CRSwNP. Read More

Crit Care Explor 2022 Jun 17;4(6):e0717. Epub 2022 Jun 17.

Department of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, MI.

To investigate the relationship between oliguric acute kidney injury (AKI) and mortality in patients with acute respiratory distress syndrome (ARDS).

Design: Retrospective cohort study.

Setting: This investigation took place at a single-center, tertiary referral multidisciplinary comprehensive healthcare hospital in metropolitan Detroit, Michigan. Read More

Cureus 2022 May 22;14(5):e25218. Epub 2022 May 22.

Respiratory Medicine, Japanese Red Cross Society Kyoto Daiichi Hospital, Kyoto, JPN.

Eosinophilic granulomatosis with polyangiitis (EGPA) refers to systemic vasculitis in patients with bronchial asthma and eosinophilic rhinosinusitis. Dupilumab has been approved for the treatment of asthma, eosinophilic rhinosinusitis, and atopic dermatitis. A man in his 50s with a history of asthma and eosinophilic rhinosinusitis with nasal polyposis developed high fever and dyspnea while undergoing dupilumab treatment. Read More

Int J Chron Obstruct Pulmon Dis 2022 17;17:1403-1408. Epub 2022 Jun 17.

Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany.

Diagnostics (Basel) 2022 Jun 9;12(6). Epub 2022 Jun 9.

1st Department of Lung Diseases, National Research Institute of Tuberculosis and Lung Diseases, 01-138 Warsaw, Poland.

Acute Eosinophilic Pneumonia (AEP) is a rare idiopathic disease caused by an accumulation of eosinophils in the pulmonary alveoli and interstitial tissue of the lungs. The onset of symptoms is acute; some patients develop respiratory failure. The diagnosis is based on clinical symptoms, diffuse interstitial infiltrates in the lungs on imaging studies, and eosinophilia exceeding 25% on bronchoalveolar lavage or pleural fluid smear. Read More

Diagnostics (Basel) 2022 Jun 2;12(6). Epub 2022 Jun 2.

Clinical Department 5, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Eosinophilic gastroenteritis (EGE) is a subgroup of the eosinophilic gastro-intestinal disorders (EGIDs), characterized by eosinophilic infiltration and chronic inflammation of the gastrointestinal tract. These are rare diseases with still incompletely elucidated causes and mechanisms, with frequently delayed diagnosis and variable outcome. Despite increased interest in eosinophilic diseases in recent years, fewer data have been published on EGE and no standardized diagnostic and therapeutic approach exists. Read More

Biomedicines 2022 Jun 15;10(6). Epub 2022 Jun 15.

Centre for Heart Lung Innovation, St Paul's Hospital, The University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.

The associations between airway eosinophilia, measured in sputum or peripheral blood, and acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are inconsistent. We therefore aimed to determine the association between eosinophilia in bronchoalveolar lavage (BAL) fluid and AECOPD in a clinical cohort. We analyzed differential cell counts from baseline BAL fluid in participants in the DISARM clinical trial (Clinicaltrials. Read More

Biomedicines 2022 Jun 9;10(6). Epub 2022 Jun 9.

Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide 5000, Australia.

Chronic rhinosinusitis (CRS) is a persistent inflammation of the nasal cavity and paranasal sinuses associated with tissue remodelling, dysfunction of the sinuses' natural defence mechanisms, and induction of different inflammatory clusters. The etiopathogenesis of CRS remains elusive, and both environmental factors, such as bacterial biofilms and the host's general condition, are thought to play a role. Bacterial biofilms have significant clinical relevance due to their potential to cause resistance to antimicrobial therapy and host defenses. Read More

Rev Med Chil 2021 Nov;149(11):1673-1678

Servicio de Neurología, Hospital Base de Valdivia, Valdivia, Chile.

Neurotoxocariasis is uncommon. Its manifestations include events of meningitis, encephalitis and less frequently vasculitis, which manifest as headache, seizures, focalization, confusion, cognitive alterations and /or fever. Peripheral eosinophilia with clinical and neurological imaging elements, allow its early suspicion. Read More

Ann Med Surg (Lond) 2022 Jun 27;78:103864. Epub 2022 May 27.

Dow University of Health Sciences-Ojha Campus, Karachi, Pakistan.

Kimura's disease is an uncommon chronic condition that often masquerades as a malignancy. It is reported predominantly in males of South-East Asia in their second and third decade of life. Most of the patients present with increased eosinophilia, follicular hyperplasia and high levels of IgE circulating in their blood. Read More

Front Immunol 2022 6;13:901194. Epub 2022 Jun 6.

Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.

The lung epithelial barrier serves as a guardian towards environmental insults and responds to allergen encounter with a cascade of immune reactions that can possibly lead to inflammation. Whether the environmental sensor aryl hydrocarbon receptor (AhR) together with its downstream targets cytochrome P450 (CYP1) family members contribute to the regulation of allergic airway inflammation remains unexplored. By employing knockout mice for AhR and for single CYP1 family members, we found that AhR and CYP1B1 but not CYP1A1 or CYP1A2 animals display enhanced allergic airway inflammation compared to WT. Read More

Case Rep Pulmonol 2022 13;2022:3627202. Epub 2022 Jun 13.

Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Respiratory Medicine Unit, Al Khobar, Saudi Arabia.

Allergic bronchopulmonary aspergillosis is an uncommon condition characterized by airway hypersensitivity to Aspergillus fumigatus, resulting in worsening asthma control and bronchiectasis progression. It is associated with various radiological features. Here, we describe a 53-year-old lady with atypical CT chest finding as soft tissue density masses in both lungs evaluated initially as a lung tumour. Read More

Br J Clin Pharmacol 2022 Jun 21. Epub 2022 Jun 21.

Laboratory Medicine, Halton Healthcare, Oakville, ON, Canada.

Ductopenia is often regarded as a chronic process where ≥50% of portal tracts lack bile ducts, which is also known as vanishing bile duct syndrome (VBDS). One etiology is drug-induced liver injury. Cloxacillin, an anti-staphylococcal penicillin, typically causes "bland" cholestasis. Read More

Int J Immunopathol Pharmacol 2022 Jan-Dec;36:3946320221109529

Department of Otorhinolaryngology, 74566The First Affiliated Hospital of Soochow University, Suzhou, China.

Eosinophilic chronic rhinosinusitis (ECRS) is a chronic inflammatory disease characterized by prominent eosinophilic infiltration along with a T-helper-2 (Th2) response. It has been well documented that signal transducer and activator of transcription 6 (STAT6) is a nuclear transcription factor that mediates Th2-type immunity and is implicatory of STAT1 and STAT3 in the pathogenesis of allergic airway diseases. However, little is known about the association between STATs and ECRS. Read More

Eur J Clin Pharmacol 2022 Jun 20. Epub 2022 Jun 20.

Service de Pharmacologie Clinique, CHU/Faculté de Médecine, Université de Monastir, Rue 1er Juin 1955, 5019, Monastir, Tunisia.

Background: To date, no study has identified a clear relationship between drug and a specific clinical presentation of DRESS.

Objectives: To investigate the particularities of DRESS and analyze the variation of DRESS pattern according to culprit drugs.

Methods: We analyzed cases of DRESS notified to the Department of Clinical Pharmacology at the University Hospital of Monastir over a 15-year period. Read More

J Allergy Clin Immunol 2022 Jun 17. Epub 2022 Jun 17.

Department of Basic Medicine, Haihe Hospital, Tianjin University, Tianjin, China; Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Tianjin, China; Department of Basic Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Lung Regenerative Medicine, Tianjin, China. Electronic address:

Background: DJ-1 is an antioxidant protein known to regulate mast cell mediated allergic response, but its role in airway eosinophilic interactions and allergic inflammation is not known.

Objective: The aim of this study was to investigate the role of DJ-1 in airway eosinophilic inflammation in vitro and in vivo.

Methods: Ovalbumin-induced airway allergic inflammation was established in mice. Read More