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J Allergy Clin Immunol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA, 37232; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, AUS, 6150; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA, 37232; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA, 37232. Electronic address:

Background: Vancomycin is a prevalent cause of the severe hypersensitivity syndrome drug reaction with eosinophilia and systemic symptoms (DRESS) which leads to significant morbidity and mortality and commonly occurs in the setting of combination antibiotic therapy which impacts future treatment choices. Variations in human leukocyte antigen (HLA) class I in particular have been associated with serious T-cell mediated adverse drug reactions which has led to preventive screening strategies for some drugs.

Objective: To determine if variation in the HLA region is associated with vancomycin-induced DRESS. Read More

Clin Lab 2019 Jan;65(1)

Myelodysplastic syndromes (MDS) with basophilia or eosinophilia are very rare and portend poor prognoses. We present a rare patient who had MDS with excess blasts as well as peripheral basophilia and concurrent bone marrow (BM) basophilia/eosinophilia. She had a complex karyotype including 5q and 7q deletions; however, no oncogenic mutations were observed on next-generation sequencing of 54 genes known to be frequently mutated in acute myeloid leukemia/MDS. Read More

Am J Ind Med 2019 Feb 18. Epub 2019 Feb 18.

Respiratory Health Division, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Morgantown, West Virginia.

Background: Non-malignant respiratory disease (NMRD) cases have occurred among rubber manufacturing workers. We examined exposure to rubber manufacturing emissions as a risk factor for NMRD.

Methods: From a systematic literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (strong, intermediate, non-significant positive association, none) between exposure to rubber manufacturing emissions and NMRD-related morbidity and mortality, and conducted two meta-analyses. Read More

Clin Pract Cases Emerg Med 2019 Feb 4;3(1):47-50. Epub 2019 Jan 4.

University of Rochester Medical Center, Department of Emergency Medicine, Rochester, New York.

We report a case of acute necrotizing eosinophilic myocarditis (ANEM) secondary to drug rash with eosinophilia and systemic symptoms (DRESS) related to administration of minocycline. Myocarditis is a rare complication of DRESS and can manifest as either a self-limited hypersensitivity myocarditis or as the frequently fatal ANEM. Due to the high morbidity and mortality caused by this disease, emergency physicians should be aware of the potential of ANEM in patients with history of DRESS and new-onset cardiac dysfunction. Read More

Am J Case Rep 2019 Feb 18;20:212-218. Epub 2019 Feb 18.

Department of Internal Medicine, Mount Sinai Hospital, Chicago, IL, USA.

BACKGROUND The hallmark of bullous pemphigoid (BP) is widespread tense blisters arising on normal or erythematous skin, often with marked pruritus, the diagnosis of which is confirmed by direct immunofluorescence (DIF). BP is an autoimmune process that can be induced, though rarely, by medications. Drug-induced BP often has atypical clinical presentation, which requires a good understanding of other dermatological conditions with similar presentations, in particular, bullous subtype of erythema multiforme. Read More

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Although tissue-eosinophilia has traditionally been considered diagnostically supportive of adverse cutaneous drug reactions (ACDRs), studies have suggested it is neither a sensitive nor a specific finding in drug eruptions (DEs).

Objectives: Determining whether skin-tissue eosinophilia is a reliable indicator of ACDR.

Methods: A nested case-control retrospective study conducted in a cohort of 170 patients at a single institution. Read More

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Pulmonary and Critical Care, Tower Health System, West Reading, Pennsylvania, USA.

Programmed cell death-1 (PD-1) inhibitors stimulate immune recognition of tumour cells in cancer patients, but have significant autoimmune side effects including pneumonitis. We report the case of a patient with asthma and mild eosinophilia who developed unusual pulmonary side effect of bronchiectasis, severe eosinophilia (absolute eosinophil count: 3200 c/mm) and elevated IgE levels (7050 IU/mL; normal: <164 IU/mL) 4 months into therapy with the PD-1 inhibitor pembrolizumab. Aspergillus fumigatus IgG was elevated at 15. Read More

Med Sci (Basel) 2019 Feb 5;7(2). Epub 2019 Feb 5.

Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a refractory upper airway disease, accompanied mainly by eosinophilia and/or asthma. In addition, the disease correlates with a high rate of hyposmia, following a marked infiltration of eosinophils into the inflamed site, the paranasal sinus. Although eosinophils are known to contribute to the development of hyposmia and CRSwNP pathology, the underlying mechanisms remain unclear. Read More

Cureus 2018 Dec 4;10(12):e3679. Epub 2018 Dec 4.

Internal Medicine, University of Central Florida College of Medicine, Orlando, USA.

We present the case of a 62-year-old Caucasian man who was being treated for mitral valve endocarditis via a six-week course of vancomycin. On Day 32 of the treatment, he developed an erythematous, pruritic, desquamating, and painful rash covering 80% of the total body surface area and intermittent fevers. Laboratory findings included leukocytosis with peripheral blood eosinophilia and elevated erythrocyte sedimentation rate, C-reactive protein, and serum creatinine. Read More

Sci Transl Med 2019 Feb;11(479)

University of Leicester, Leicester LE3 9QP, UK.

Increased airway smooth muscle mass, a feature of airway remodeling in asthma, is the strongest predictor of airflow limitation and contributes to asthma-associated morbidity and mortality. No current drug therapy for asthma is known to affect airway smooth muscle mass. Although there is increasing evidence that prostaglandin D type 2 receptor (DP) is expressed in airway structural and inflammatory cells, few studies have addressed the expression and function of DP in airway smooth muscle cells. Read More

Trop Med Infect Dis 2019 Feb 12;4(1). Epub 2019 Feb 12.

Department of Medicine, Division of Infectious Diseases, University of Texas Health, San Antonio, TX 78229, USA.

Strongyloidiasis, due to infection with the nematode , affects millions of people in the tropics and subtropics. has a unique auto-infective lifecycle such that it can persist in the human host for decades. In immunosuppressed patients, especially those on corticosteroids, potentially fatal disseminated strongyloidiasis can occur, often with concurrent secondary infections. Read More

J Helminthol 2019 Feb 13:1-4. Epub 2019 Feb 13.

Department of Infectious Diseases, Istituto Superiore di Sanità,Rome,Italy.

Trichinellosis is a cosmopolitan zoonotic parasitic disease caused by the nematodes of the genus Trichinella, through the consumption of raw or semi-raw infected meat from swine, horses and wild animals. This disease has been sporadically reported in Greece since 1946. The aim of the present study was to describe a trichinellosis case in a patient hospitalized in northern Greece, in 2017. Read More

Eur J Case Rep Intern Med 2018 24;5(4):000836. Epub 2018 Apr 24.

Internal Medicine Department, Centro Hospitalar de São João, Porto, Portugal.

Tricuspid stenosis is an uncommon valvular abnormality commonly associated with other valvular lesions. Ebstein's anomaly is a rare congenital heart malformation characterized primarily by abnormalities of the tricuspid valve and right ventricle. Endomyocardial fibrosis is a restrictive cardiomyopathy observed in tropical and subtropical regions. Read More

Eur J Case Rep Intern Med 2018 28;5(11):000971. Epub 2018 Nov 28.

Division of Rheumatology, Emek Medical Center, Itzhak Rabin Blvd., Afula, Israel.

A 36-year-old woman with eosinophilic granulomatosis with polyangiitis (EGPA) presented with necrotic skin lesions and pulmonary infiltrates. There was eosinophilic vasculitis on skin biopsy, and substantial tissue eosinophilia in her bone marrow. She had unexplained worsening thrombocytopenia, which prompted a thrombophilia work-up. Read More

Mymensingh Med J 2019 Jan;28(1):150-156

Dr Md Abdul Mumit Sarkar, Resident, Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Several mechanisms have been proposed to explain the symptoms of functional dyspepsia but actual pathogenesis is still poorly understood. Recent studies support duodenal abnormality to be the most important causal link to explain symptoms and to understand abnormal pathophysiology of functional dyspepsia. The aim of this prospective observational study is to compare eosinophil count in duodenal mucosa between patients with functional dyspepsia and control subjects without dyspepsia and was done at the department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from December 2015 to December 2016. Read More

J Clin Pathol 2019 Feb 12. Epub 2019 Feb 12.

Department of Pathology, University Health Network, Toronto, Ontario, Canada.

Aims: Renal tumour biopsy (RTB) is increasingly recognised as a useful diagnostic tool in the management of small renal masses, particularly those that are incidentally found. Intratumoural heterogeneity with respect to morphology, grade and molecular features represents a frequently identified limitation to the use of RTB. While previous studies have evaluated pathological correlation between RTB and nephrectomy, no studies to date have focused specifically on the role of RTB for the diagnosis of papillary renal cell carcinoma (PRCC) and its further subclassification into clinically relevant subtypes. Read More

Innate Immun 2019 Feb 12:1753425919829554. Epub 2019 Feb 12.

3 Research Center of Allergy & Immunology, Shenzhen University School of Medicine, China.

Survivin is an anti-apoptosis protein that may be associated with the development of eosinophilia; the latter is associated with the pathogenesis of many immune disorders. Here we report that less apoptotic eosinophils (Eos) were induced in those isolated from mice suffering from food allergy (FA) than those from naive mice after treating with cisplatin in vitro. Exposure to cisplatin induced more Fas ligand (FasL) expression in Eos isolated from naive mice than in those of FA mouse. Read More

J Thorac Dis 2018 Dec;10(12):6585-6597

Otorhinolaryngology Hospital, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

Background: Periostin has been shown to be upregulated in chronic rhinosinusitis with nasal polyps (CRSwNP), especially in the CRSwNP patients with asthma. However, the underlying mechanism that how periostin contributes to the polyp genesis remains unclear.

Methods: In this study, we collected 63 CRSwNP patients' nasal polyps (NPs) and 25 control subjects' uncinated tissues. Read More

Indian J Dermatol 2019 Jan-Feb;64(1):77-80

Department of Dermatology and Venereology, Government Medical College, Kozhikode, Kerala, India.

Indian J Dermatol 2019 Jan-Feb;64(1):34-40

Department of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic.

Background: Eosinophils play an important pathogenic role in atopic dermatitis (AD), but its exact function remains to be determined.

Aims And Objectives: The aim of this study was to correlate the eosinophil count with the manifestations such as asthma bronchiale, rhinitis, level of total IgE, sensitization to mites, animal dander, bird feather, dust, mixture of grass, mixture of trees, mixture of fungi, duration of lesions (persistent or occasional during last year), family history about atopy, and onset of AD (under or above 5 year of age).

Materials And Methods: Two hundred and seventy-two patients suffering from AD at the age of 14 year or older were examined - 100 men and 172 women with the average age of 26. Read More

J Allergy Clin Immunol 2019 Feb 7. Epub 2019 Feb 7.

Department of Otolaryngology, Mayo Clinic, Phoenix, AZ; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic, Scottsdale, AZ; Division of Pulmonology, Phoenix Children's Hospital, Phoenix, AZ. Electronic address:

Eosinophil peroxidase is a potential biomarker for eosinophilic chronic rhinosinusitis. Th2/Th1 polarization, as measured by GATA3 and T-bet, was not associated with eosinophilia or any clinical or histopathologic feature of chronic rhinosinusitis. Read More

J Am Acad Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Service de Médecine Interne, Université Versailles Saint-Quentin-en-Yvelines, Centre de Référence des Syndromes Hyperéosinophiliques (CEREO), Hôpital Foch, Suresnes, France.

Background: Episodic Angioedema with eosinophilia (EAE, Gleich's syndrome) is a rare disorder consisting of recurrent episodes of angioedema, hypereosinophilia and frequent elevated serum Immunoglobin M.

Methods: We conducted a retrospective multicenter nationwide study regarding the clinical spectrum and therapeutic management of patients with EAE in France.

Results: Thirty patients were included with a median age at diagnosis of 41 years [5-84]. Read More

J Am Acad Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, University of California, San Francisco, San Francisco, CA. Electronic address:

Background: While hypersensitivity reactions are well-characterized for certain medications, vancomycin-associated drug-induced hypersensitivity syndrome (DIHS), or drug reaction with eosinophilia and systemic symptoms (DRESS), has yet to be defined.

Objective: To better define the clinical phenotype of vancomycin-associated DIHS.

Methods: A retrospective case series was conducted over an 8-year period at a single, academic institution. Read More

J Invest Dermatol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei and Keelung, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taiwan; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan. Electronic address:

Drug reaction with eosinophilia and systemic symptom (DRESS) is life-threatening disorder with an estimated mortality of 2%. Recently, type II innate lymphoid cells (ILC2s) has been implicated as an important contributor to the pathogenesis of allergic disorders. However, whether the roles of ILC2s and ILC2-associated cytokines in DRESS remain unclear. Read More

Eur Respir J 2019 Feb 6. Epub 2019 Feb 6.

Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona, USA

The inflammatory responses in chronic airway diseases leading to emphysema are not fully defined. We hypothesised that lung eosinophilia contributes to airspace enlargement in a mouse model, and emphysema in patients with COPD.A transgenic mouse model of chronic type 2 pulmonary inflammation ( ) was used to examine eosinophil-dependent mechanisms leading to airspace enlargement. Read More

Acta Haematol 2019 Feb 6;141(2):119-127. Epub 2019 Feb 6.

Department of Pediatric Hematology-Oncology, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel.

Background: The WHO defined myeloid and lymphoid neoplasms (MLN) with eosinophilia associated with PDGFRB, PDGFRA, FGFR1 rearrangements as a new entity in 2016. PDGFRB-rearranged MLN sensitive to imatinib were described in adult patients. We report the first pediatric patient with PDGFRB-rearranged myeloproliferative disorder associated with T-lymphoblastic lymphoma bearing the t(5; 14)(q33;q32) translocation who was successfully treated with imatinib only. Read More

Am J Respir Crit Care Med 2019 Feb 6. Epub 2019 Feb 6.

University of Wisconsin, Medicine, Madison, Wisconsin, United States.

Severe asthma affects a small proportion of asthma patients (~ 3-5%) and reflects a failure of conventional asthma medications to provide adequate control. Severe asthma is a disease of significant clinical heterogeneity, likely caused by different pathobiological mechanisms, frequently referred to as endotypes. In the last decade, multiple monoclonal therapies have been developed to target airway type-2 eosinophilic and/or allergic severe asthma. Read More

JCI Insight 2019 Feb 5. Epub 2019 Feb 5.

The dysregulated, unbalanced immune response of sepsis results in a mortality exceeding 20%, yet recent findings by our group indicate that patients with allergic, type 2-mediated immune diseases are protected from developing sepsis. We evaluated CD4+ T helper (Th) cell polarization among patients with Staphylococcus aureus bacteremia and confirmed that survivors had a higher percentage of circulating Th2 cells, but lower frequencies of Th17 cells and neutrophils early in the course of infection. To establish the mechanism of this protection, we employed a mouse model of lethal S. Read More

J Asthma 2019 Feb 5. Epub 2019 Feb 5.

b Dr DY Patil University , Pune , India.

An Sist Sanit Navar 2019 Feb 5;0(0):67385. Epub 2019 Feb 5.

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Eosinophilic granulomatosis with polyangiitis (EGPA), or Churg-Strauss syndrome, is a rare disease characterized by disseminated necrotizing vasculitis with extravascular granulomas occurring among patients with asthma and tissue eosinophilia. Clinically, it presents in various ways and progresses in three phases: prodromic (asthma and rhino-sinusitis), eosinophilic (peripheral eosinophilia and organ involvement), and vasculitic (clinical manifestations due to small vessel vasculitis). The differential diagnosis of EGPA principally includes eosinophilic and vasculitic disorders, early treatment is needed to avoid a fatal outcome. Read More

Anesth Pain Med 2018 Dec 28;8(6):e84179. Epub 2018 Nov 28.

Department of Internal Medicine, Division of Rheumatology, Jeju National University Hospital, Jeju, Korea.

Introduction: Churg-Strauss syndrome (CSS; or eosinophilic granulomatosis with polyangiitis) is an extremely rare autoimmune condition characterized by hypereosinophilia and vasculitis of small or medium-sized blood vessels, occurring in patients with asthma and allergic rhinitis.

Case Presentation: A 47-year-old man (height, 175.8 cm and weight, 74. Read More

J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan.

The role of eosinophil in systemic sclerosis (SSc) is still controversial. In the present study, the relationship between skin ulcers and peripheral blood eosinophilia were analyzed in patients with SSc. We retrospectively investigated the clinical records of all patients who were diagnosed with SSc on the basis of American College of Rheumatology/European League Against Rheumatism 2013 criteria, and were followed up for more than 2 years at Wakayama Medical University. Read More

Acta Trop 2019 Jan 30. Epub 2019 Jan 30.

Beijing Institute of Tropical Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, PR China; Beijing Key Laboratory for Research on Prevention and Treatment of Tropical Diseases, Beijing, 100050, PR China. Electronic address:

Hepatic capillariasis is a rare and neglected parasitic disease caused by infection with Capillaria hepatica in human liver. The disease is not well described and the information for the disease's clinical manifestation, laboratory findings and disease management strategy is not well reported. The limited information for this neglected infection often results in the delay of diagnosis or misdiagnosed to other diseases, therefore the real prevalence or severity of the infection may be underestimated. Read More

Clin Exp Allergy 2019 Feb 1. Epub 2019 Feb 1.

Aix Marseille University, Inserm, INRA, C2VN, Marseille, France.

Background: Goblet Cell Hyperplasia (GCH) is a pathological finding classically reported across asthma severity levels and usually associated with smoking. Multiple biological mechanisms may contribute to excessive mucus production.

Objective: We aimed to decipher the clinical meanings and biological pathways related to GCH in non smokers with asthma. Read More

Curr Drug Saf 2019 Jan 30. Epub 2019 Jan 30.

National Center Chalbi Belkahia of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis.. Tunisia.

Imatinib is the treatment of choice in patients with locally advanced or metastatic gastrointestinal stromal tumours (GIST). Clinical tolerance of imatinib is excellent except the common adverse drug reaction (ADR). Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a severe, potentially life-threatening drug-induced hypersensitivity reaction, characterized by cutaneous eruptions, fever, diffuse lymphadenopathy, along with eosinophilia, and elevated liver function tests. Read More

Haematologica 2019 Jan 31. Epub 2019 Jan 31.

Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, Canada.

IgG4-related disease is a fibroinflammatory condition that can affect nearly any organ system. Common presentations include major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal fibrosis and tubulointerstitial nephritis. This review focuses on the hematological manifestations of IgG4-related disease, including lymphadenopathy, eosinophilia, and polyclonal hypergammaglobulinemia. Read More

Respir Med 2019 Feb 9;147:44-50. Epub 2019 Jan 9.

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea. Electronic address:

Background: Delayed drug hypersensitivity to first-line anti-tuberculosis medication is a major challenge in tuberculosis treatment.

Objective: This study was performed to investigate the efficacy/tolerability of desensitization therapy in treatment of first-line anti-tuberculosis medication hypersensitivity and the usefulness of immunologic evaluation therein.

Methods: This study was conducted as a prospective, observational cohort study. Read More

Medicine (Baltimore) 2019 Feb;98(5):e14238

Department of Pediatrics, West China Second Hospital, Sichuan University.

Tuberculosis pleural effusion (TPE) and parasitic pleural effusion (PPE) present with similar clinical manifestations. We evaluated the pleural fluid features of TPE and PPE.A total of 76 patients with pleuritis, including 25 patients with TPE and 51 patients with PPE were retrospectively studied. Read More

J Appl Toxicol 2019 Jan 30. Epub 2019 Jan 30.

Department of Environmental Toxicology, University of California, Davis, CA, 95616, USA.

Simultaneous exposure of lipopolysaccharide (LPS) and urban particulate matter <2.5 μm (PM2.5) or desert dust exacerbated murine asthma. Read More

Clin Exp Allergy 2019 Jan 28. Epub 2019 Jan 28.

Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia.

Hypersensitivity drug reactions (HDRs) are an immense public health problem where significant proportions may lead to mortality. HDRs can manifest in various phenotypes, mainly cutaneous reactions that range from the mild; i.e. Read More

Australas J Dermatol 2019 Jan 29. Epub 2019 Jan 29.

Department of Pathology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

Trop Parasitol 2018 Jul-Dec;8(2):121-123. Epub 2018 Dec 27.

Department of Pathology, ESI Hospital, Rohini, Delhi, India.

Detection of adult gravid filarial worm in fine-needle aspiration cytology (FNAC) smears is unusual despite the high incidence of this parasite in endemic zones. Bancroftian filariasis presenting as subcutaneous nodules is very rare, and only a few cases are reported in literature. In spite of various reports stating the presence of microfilaria using aspiration cytology in various sites, the presence of an adult gravid filarial worm in subcutaneous nodules by FNAC is an extremely rare finding. Read More

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):108-111

Department of Family Medicine, VPS Lakeshore Hospital, Kochi, Kerala, India.

Normal cerebrospinal fluid (CSF) does not contain eosinophils. The presence of >10 eosinophils/μL in CSF or at least 10% eosinophils in total CSF leukocyte count confirms eosinophilic meningitis. We present three patients with eosinophilic meningitis from the same locality with peripheral eosinophilia. Read More

Perit Dial Int 2019 Jan-Feb;39(1):90-92

Nephrology, Nagoya University Postgraduate School of Medicine, Nagoya, Japan.

As a rare complication in patients on peritoneal dialysis (PD), increase of eosinophil (peritoneal dialysate fluid [PDF] eosinophilia), including eosinophilic peritonitis, was observed in PDF. The majority of eosinophilic peritonitis cases are detected during the early phase of PD induction. However, the frequency of and mechanisms underlying PDF eosinophilia remain unclear. Read More

Clin Chest Med 2019 Mar;40(1):227-241

Asthma UK, 18 Mansell Street, London E1 8AA, UK.

Although once considered a single disease entity, asthma is now known to be a complex inflammatory disease engaging a range of causal pathways. The most frequent forms of asthma are identified by sputum/blood eosinophilia and activation of type 2 inflammatory pathways involving interleukins-3, -4, -5, and granulocyte-macrophage colony-stimulating factor. The use of diagnostics that identify T2 engagement linked to the selective use of highly targeted biologics has opened up a new way of managing severe disease. Read More

Allergy 2019 Jan 28. Epub 2019 Jan 28.

Pharmacology& Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.

Background: Siglec-7 is an inhibitory receptor (IR) expressed on human blood eosinophils. Whereas activation of other IRs, including Siglec-8 and CD300a, has been shown to downregulate eosinophil function, little is known about the role of Siglec-7 on human eosinophils.

Objective: To examine Siglec-7 expression and function in eosinophils from normal (ND) and eosinophilic (EO) donors. Read More

Rhinology 2019 Feb;57(1):67-72

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: This study aims to compare histopathology of nasal polyp and ethmoid mucosa for diagnosing eosinophilic mucin rhinosinusitis (EMRS).

Methodology: Patients with chronic rhinosinusitis with polyps (CRSwNP) were enrolled. Using eosinophilic mucin as a reference, histopathology of polyp apex, polyp pedicle and ethmoid mucosa was compared for density of tissue eosinophil and sensitivity for diagnosing EMRS. Read More

Front Immunol 2018 9;9:3031. Epub 2019 Jan 9.

Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University Hospital, Osaka-Sayama, Japan.

Myelodysplastic syndromes (MDS) are a heterogeneous group clonal disorders of hematopoietic stem cells (HSC) characterized by ineffective hematopoiesis that lead to variable grades of impaired blood cell production. Chromosomal aberrations are often detected in MDS patients and thus cytogenetic analysis is useful for the diagnosis of these disorders. Common recurring chromosomal defects, such as the -5/5q- and -7/7q- are relatively well characterized cytogenetic abnormalities in MDS, however, the biological significance of uncommon cytogenetic alterations is unknown. Read More