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Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

Weill Cornell Medicine, New York, NY.

A striking dermatitis referred to by its colloquial designation of sabra dermatitis is associated with glochidia inoculation from the Opuntia cactus commonly known as the prickly pear. We report a 45-year-old woman who had an unexpected encounter with a cactus plant during a trip to Texas. She brushed up against the plant and was aware that she had been inoculated with several spines of the plant. Read More

Niger J Clin Pract 2020 Jul;23(7):1008-1012

Department of Pediatric Surgery, Firat University School of Medicine, Elazig, Turkey.

Objectives: The relationship hydatid cyst (HC) is a parasitic disease that is endemic worldwide.

Aims: To study the clinical findings and laboratory results of patients with hydatid disease.

Materials And Methods: Total number of patients (n = 78) who underwent surgery for HC disease from 2000 to 2017 were retrospectively evaluated. Read More

Am J Trop Med Hyg 2020 Jul 6. Epub 2020 Jul 6.

Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Valencia, Spain.

Fascioliasis is reported in five Vietnamese children aged 4 years or younger. A 10-month-old girl child and a 12-month-old boy child are the youngest patients ever diagnosed. Eggs in stools suggested an infection occurred at 5-6 months and 7-8 months of age, respectively. Read More

Eur Heart J Case Rep 2020 Jun 1;4(3):1-5. Epub 2020 Jun 1.

Cardiology Department, Reims University Hospital, Avenue du Général Koenig, 51092 Reims, France.

Background: Endomyocardial fibrosis (EMF) is a rare cause of restrictive cardiomyopathy, mainly found in tropical/subtropical country. Endomyocardial fibrosis causes severe congestive symptoms and may lead to end-stage heart failure.

Case Summary: A French Caucasian 44-year-old man without noticeable medical history and who had never travelled outside of France was hospitalized for a first episode of acute heart failure revealing an atypical appearance of the left ventricle. Read More

Cureus 2020 May 28;12(5):e8341. Epub 2020 May 28.

Internal Medicine, Hospital Corporation of America West Florida GME Consortium, Brooksville, USA.

Hypereosinophilic syndrome (HES) is a rare clinical disease that affects 0.036/100,000 patients, with a minority of patients having associated genetic markers which can encompass PDGFRA/B or FGFR1 mutations. The prognosis is dependent on the timing of diagnosis and early treatment, with a mortality rate ranging from 48% to 75% if there is a delayed diagnosis. Read More

Ophthalmologe 2020 Jul 1. Epub 2020 Jul 1.

Klinik für Augenheilkunde, Universitätsmedizin Göttingen, Göttingen, Deutschland.

A 9‑year-old patient presented with a reduction of visual acuity in the left eye, which was incidentally noticed 2 weeks previously. Funduscopy revealed a mild vitritis, a pale optic disk, narrowed blood vessels and an increased reflex of the retinal surface. The values in the blood examination were normal apart from eosinophilia and an elevated immunoglobulin E (IgE) antibody titer. Read More

JAAD Case Rep 2020 Jul 11;6(7):663-665. Epub 2020 May 11.

Department of Dermatology, Mashhad University of Medical Sciences, Mashhad, Iran.

World Allergy Organ J 2020 Jun 23;13(6):100129. Epub 2020 Jun 23.

Department for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, Goethe University, Frankfurt, Germany.

Purpose: The prevalence of "ocal allergic rhinitis" within individuals suffering from perennial rhinitis remains uncertain, and patients usually are diagnosed with non-allergic rhinitis. The aim of this study was to evaluate the prevalence of a potential "local allergic rhinitis" in subjects suffering from non-allergic rhinitis in a non-selected group of young students.

Methods: 131 students (age 25. Read More

BMJ Open 2020 Jul 1;10(7):e035811. Epub 2020 Jul 1.

Maladies Respiratoires, Univ Montpellier, CHU Montpellier, Montpellier, France.

Objectives: Presently, those outcomes that should be prioritised for chronic obstructive pulmonary disease (COPD) exacerbation studies remain unclear. In order to coordinate multicentre studies on eosinophilia-driven corticosteroid therapy for patients hospitalised for acute exacerbation of COPD (AECOPD), we aimed to find consensus among experts in the domain regarding the prioritisation of outcomes.

Design: A modified Delphi study was proposed to recognised COPD experts. Read More

Tuberc Respir Dis (Seoul) 2020 Jul 18;83(3):175-184. Epub 2020 Jun 18.

Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton and the Department of Medicine, McMaster University, Hamilton, ON, Canada.

Quantitative sputum cytometry facilitates in assessing the nature of bronchitis associated with exacerbations of chronic obstructive pulmonary disease (COPD). This is not assessed in most clinical trials that evaluate the effectiveness of strategies to prevent or to treat exacerbations. While up to a quarter of exacerbations may be associated with raised eosinophil numbers, the vast majority of exacerbations are associated with neutrophilic bronchitis that may indicate airway infections. Read More

Dermatol Online J 2020 Mar 15;26(3). Epub 2020 Mar 15.

Department of Dermatovenereology, Hospital de Braga, Braga.

Eosinophilic dermatosis of hematologic malignancy (EDHM) is a dermatosis characterized by tissue eosinophilia that has been previously reported as insect bite-like reaction. It is a rare condition with a wide variety of clinical presentations ranging from papules, nodules, or blisters that simulate arthropod bites, to the formation of plaques of differing sizes. We report a case of eosinophilic dermatosis of hematologic malignancy in a patient with a hematoproliferative disorder. Read More

Clin Exp Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Department of Dermatology, Hopital Bichat-Claude Bernard, Paris, France.

We read with great interest the article recently published by Choudhary et al, reporting a fatal case of acute hepatitis failure as complication of a teriflunomide-induced drug reaction with eosinophilia and systemic symptoms (DRESS). This hepatitis failure developed after the patient suddenly stopped corticosteroids. Read More

J Clin Med 2020 Jun 24;9(6). Epub 2020 Jun 24.

Department of Dermatology, National Medical Center, Seoul 04564, Korea.

Among biological agents for the treatment of atopic dermatitis (AD), dupilumab is a front-runner. Although many studies have been conducted on the real-world use of dupilumab, the sample size is often small and data is primarily on Western people. Therefore, we investigated the efficacy and safety of dupilumab in patients with moderate-to-severe AD in Korea. Read More

Ter Arkh 2020 Apr 27;92(3):25-29. Epub 2020 Apr 27.

Ulyanovsk State University.

Aim: To assess the risk of exacerbations of bronchial asthma (BA) in smoking patients with the asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) after inpatient treatment.

Materials And Methods: 36 smokers with ACO (main group) and 36 non-smoking patients (control group) with severe or moderate exacerbation of bronchial asthma were examined. Assessment of the severity of exacerbation of BA before treatment, levels of control and risk of exacerbations of BA after treatment was determined according to the Federal clinical guidelines for the diagnosis and treatment of BA (2016). Read More

Ter Arkh 2019 May 15;91(5):40-48. Epub 2019 May 15.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).

Aim: to propose diagnostic algorithm of IgG4-related disease (IgG4-RD).

Materials And Methods: One center retrospective research. 52 pts with IgG4-RD were included. Read More

Ter Arkh 2019 Oct 15;91(10):144-152. Epub 2019 Oct 15.

Sechenov First Moscow State Medical University (Sechenov University).

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease that combines various clinical manifestations and pathophysiological mechanisms. It underlies the separation of patients with COPD by phenotypes, endotypes and a personalized therapy of this disease. The implementation of this approach is possible only with the use of appropriate biomarkers. Read More

Ter Arkh 2019 Nov 15;91(11):66-71. Epub 2019 Nov 15.

Nesterov Department of Faculty Therapy Pirogov Russian National Research Medical University.

The aim of the present report is to describe a clinical case of toxocariasis. 37-year - old man was admitted to Pirogov Municipal Clinical Hospital No.1 in Moscow. Read More

Ter Arkh 2019 Dec 15;91(12):47-56. Epub 2019 Dec 15.

Teva Limited Liability Company.

Asthma is a heterogeneous chronic disease of airways. One of its endotypes is eosinophilic asthma, accompanied by both peripheral blood and airway eosinophilia, where severe eosinophilia is usually associated with more severe asthma. Anti - interleukin-5 (IL-5) monoclonal antibodies (MAb) can reduce eosinophil counts in peripheral blood and tissues in asthma patients. Read More

Curr Clin Pharmacol 2020 Jun 28. Epub 2020 Jun 28.

Department of Pharmacy Practice, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru. India.

Background: Signal strength for any drug event combination can be determined using disproportionality analysis. Vemurafenib is a BRAF inhibitor approved by the US Food and Drug Administration (FDA) in 2011 for the treatment of metastatic melanoma. This study aims to identify the signal strength of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) associated with vemurafenib using disproportionality analysis in FDA database of Adverse Event Reporting System (FAERS). Read More

Arkh Patol 2020 ;82(3):47-50

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russia, Moscow, Russia.

The article describes the case of a 42-year-old young woman with Löffler's endomyocarditis (fibroplastic endomyocarditis with eosinophilic syndrome). Pathomorphological (macroscopic and histological) criteria for the diagnosis of this rare form of restrictive cardiomyopathy are presented. Read More

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):352-361

Department of Infectious Diseases, Centre for Antibiotic Allergy and Research, Austin Health.

Purpose Of Review: Glycopeptide antibiotics such as vancomycin are frequently utilized to treat resistant Gram-positive infections such as methicillin-resistant Staphylococcus aureus. The current literature on glycopeptide and lipoglycopeptide structure, hypersensitivity and potential cross-reactivity was reviewed, highlighting implications for safe prescribing.

Recent Findings: Structurally similar, glycopeptides could theoretically cross-react. Read More

J Pediatr Hematol Oncol 2020 Jun 23. Epub 2020 Jun 23.

Departments of Pediatrics.

Kimura disease commonly presents as an isolated swelling over the head and neck region. Intestinal involvement by Kimura disease in children is uncommonly reported. We report a 10-year-old boy who had presented with an ileocaecal mass with peripheral blood eosinophilia and elevated immunoglobulin E levels. Read More

Med Klin Intensivmed Notfmed 2020 Jun 25. Epub 2020 Jun 25.

Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland.

Stem Cell Res Ther 2020 Jun 26;11(1):254. Epub 2020 Jun 26.

Hematology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpodae-ro, Seocho-gu, Seoul, 06591, South Korea.

Background: Human chronic graft-versus-host disease (CGVHD) shares clinical characteristics with a murine sclerodermatous GVHD (Scl-GVHD, B10.D2 → BALB/c) model that is characterized by skin and lung fibrosis. In this study, bone marrow- or adipose tissue-derived human mesenchymal stem cells (hMSCs) were injected into the Scl-GVHD mice to address their therapeutic effect on CGVHD. Read More

Pathogens 2020 Jun 23;9(6). Epub 2020 Jun 23.

Barcelona Institute for Global Health, ISGlobal-Hospital Clinic, Universitat de Barcelona, 08036 Barcelona, Spain.

is a widely distributed nematode more frequent in tropical areas and particularly severe in immunosuppressed patients. The aim of this study was to determine factors associated with strongyloidiasis in migrants living in a non-endemic area and to assess the response to treatment and follow-up in those diagnosed with the infection. We performed a multicenter case-control study with 158 cases and 294 controls matched 1:2 by a department service. Read More

Australas J Dermatol 2020 Jun 25. Epub 2020 Jun 25.

Concord Repatriation General Hospital, Concord, NSW, Australia.

Eosinophilic cellulitis is a rare inflammatory skin disease of unknown aetiology, first described by George Wells in 1971 as a recurrent granulomatous dermatitis with eosinophilia. It is typically characterised by recurrent pruritic erythematous plaques, vesicles or bullae usually involving the extremities and trunk. Many cases of eosinophilic cellulitis are difficult to treat and traditionally require long course of oral steroids, resulting in steroid side effects. Read More

Antiviral Res 2020 Jun 22:104864. Epub 2020 Jun 22.

Department of Virology, Institute of Experimental Medicine, Saint Petersburg, Russia. Electronic address:

Respiratory syncytial virus (RSV) can cause recurrent infection in people because it does not stimulate a long-lived immunological memory. There is an urgent need to develop a safe and efficacious vaccine against RSV that would induce immunological memory without causing immunopathology following natural RSV infection. We have previously generated two recombinant live attenuated influenza vaccine (LAIV) viruses that encode immunodominant T-cell epitopes of RSV M2 protein in the neuraminidase or NS1 genes. Read More

Am J Respir Crit Care Med 2020 Jun 25. Epub 2020 Jun 25.

McMaster University, 3710, Medicine, Hamilton, Ontario, Canada;

Rationale: Group 2 innate lymphoid cells (ILC2s) are critical for type 2 inflammation. In murine models of asthma, some ILC2s remain activated in the absence of epithelial-derived cytokine signaling, implicating alternate stimulatory pathways. Death receptor 3 (DR3), a member of the tumor necrosis factor receptor superfamily is expressed on ILC2s and genome wide association studies report an association between DR3 ligand, TNF like protein 1A (TL1A), and chronic inflammatory conditions. Read More

Pathol Oncol Res 2020 Jun 24. Epub 2020 Jun 24.

Department of Biopathology, Academic Hospital, rue du Général Koenig, 51100, Reims, France.

Describe clinical, histological and molecular charatcteristics and prognosis values of the serrated candidate markers AnnexinA10 and Gremlin1 in colon adenocarcinomas. Immunohistochemical expression of AnnexinA10 and Gremlin1 was evaluated on 346 colonic adenocarcinomas. Clinicopathological, molecular features and prognostic characteristics were then evaluated. Read More

Front Immunol 2020 4;11:1092. Epub 2020 Jun 4.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Utrecht, Netherlands.

There is a strong correlation between dysregulation of the gastrointestinal microbiota and development of allergic diseases. The most prevalent therapies for relieving asthma symptoms are associated with serious side effects, and therefore novel approaches are needed. Our objective was to elucidate whether oral administration of GG (LGG) as a probiotic or turmeric powder (TP) as a prebiotic or both as a synbiotic mitigate allergic inflammation including lung function, airway inflammatory cell infiltration, Th2 cytokines/chemokine in a murine model of house dust mite (HDM)-induced asthma. Read More

Front Immunol 2020 2;11:1058. Epub 2020 Jun 2.

Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Eosinophils develop from CD34 progenitor cells in the bone marrow under the influence of interleukin (IL)-5. Several cell types produce IL-5, including type 2 innate lymphoid cells (ILC2s). The alarmin cytokine IL-33 is known to activate ILC2s in mucosal tissues, but little is known about IL-33-responsive ILC2s in the bone marrow in allergen-induced airway inflammation. Read More

Trop Med Int Health 2020 Jun 24. Epub 2020 Jun 24.

Makerere University Infectious Disease Institute, Kampala, Uganda.

Objective: To determine clinical correlates of the peripheral absolute eosinophil count (AEC) among bacteriologically confirmed TB patients in Uganda.

Materials And Methods: We evaluated data of bacteriologically confirmed adult TB patients who had a peripheral blood AEC measurement at the National TB Treatment Center in Uganda during a cross sectional study. We performed linear regression analysis for correlates of log transformed AEC. Read More

Exp Lung Res 2020 Jun 24:1-15. Epub 2020 Jun 24.

Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN, USA.

Exposure to various allergens has been shown to increase expression of ORMDL3 in the lung in models of allergic asthma. Studies using genetically modified (transgenic or knock out) mice have revealed some of the functions of ORMDL3 in asthma pathogenesis, although amid debate. The goal of this study was to use targeted post-transcriptional downregulation of in allergen-challenged wild-type (WT) mice by RNA interference to further elucidate the functional role of ORMDL3 in asthma pathogenesis and evaluate a potential therapeutic option. Read More

Dermatol Ther (Heidelb) 2020 Jun 23. Epub 2020 Jun 23.

Department of Dermatology, University of Rzeszow, Rzeszow, Poland.

Eosinophilic annular erythema (EAE) is a rare condition with a chronic relapsing and remitting course, characterized by the presence of annular or polycyclic erythematous and plaque lesions and prominent tissue eosinophilia on histopathology. There is an ongoing discussion on whether EAE is a subset of Wells syndrome (eosinophilic cellulitis) or a separate entity. To date, few cases of EAE have been reported in the literature; of these, about 40 cases were in adults and fewer than ten cases were in children. Read More

World Allergy Organ J 2020 Jul 17;13(7):100134. Epub 2020 Jun 17.

Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, 100730, China.

Background: The diagnosis and treatment of nonallergic rhinitis with eosinophilia syndrome (NARES) remain controversial. The aim of this study was to evaluate whether Cystatin SN together with symptoms can be used to diagnose NARES and to measure the efficiency of medical treatment.

Methods: Seventy-five patients with chronic rhinitis (CR) and 18 control subjects were enrolled. Read More

Surg Obes Relat Dis 2020 May 13. Epub 2020 May 13.

Department of Surgery, University of Colorado, and Children's Hospital Colorado, Aurora, Colorado; Department of Pediatrics, University of Colorado, and Children's Hospital Colorado, University of Colorado, Aurora, Colorado. Electronic address:

Background: Vertical sleeve gastrectomy (VSG) has been associated with gastroesophageal reflux symptoms and, in adults, with a development of Barrett's esophagus. Adults with Barrett's esophagus identified at baseline before bariatric operation are generally advised against VSG operations. The role of preoperative esophagogastroduodenoscopy (EGD) in adolescents preparing for bariatric surgery is not clearly defined. Read More

J Asthma 2020 Jul 1:1-7. Epub 2020 Jul 1.

Department of Internal Medicine, Allergy and clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Asthma is a common chronic inflammatory air way disease which poses a high disease burden worldwide. Asthma is a heterogenous disease with various phenotypes and endotypes. Refractory asthma requires new and personalized approaches to manage it effectively. Read More

Expert Rev Clin Pharmacol 2020 Jul 2:1-9. Epub 2020 Jul 2.

The Zucker Hillside Hospital, Psychiatry Research, Northwell Health , Glen Oaks, NY, USA.

Introduction: The Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a severe, multiorganic, and potentially life-threatening drug-induced hypersensitivity reaction, linked to several common drugs, including antiepileptics, antibiotics, and several psychotropic drugs, including clozapine. Due to the importance of clozapine in the management of treatment-resistant schizophrenia, a systematic review and characterization of clozapine-related DRESS syndrome is long overdue.

Areas Covered: This systematic review was conducted following PRISMA guidelines. Read More

J Immunol 2020 Jun 22. Epub 2020 Jun 22.

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom

Helminth infections are accompanied by eosinophilia in parasitized tissues. Eosinophils are effectors of immunity to tissue helminths. We previously reported that in the context of experimental filarial nematode infection, optimum tissue eosinophil recruitment was coordinated by local macrophage populations following IL-4R-dependent in situ proliferation and alternative activation. Read More

Leuk Res Rep 2020 8;14:100209. Epub 2020 Jun 8.

Cytogenetic division, Kariminejad,Najmabadi Pathology & Genetics Center, Tehran, Iran.

The most common childhood malignancy is acute leukemia. Approximately 15- 20% of it, is Acute myeloid leukemia (AML). The general symptoms of this malignancy include fatigue, weakness, fever, paleness and bleeding disorders. Read More

Am J Rhinol Allergy 2020 Jun 20:1945892420936196. Epub 2020 Jun 20.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background: in the era of new biological agents it is important to identify patients who may benefit from conventional therapies such as endoscopic sinus surgery (ESS) plus long-term local corticosteroids from those with patterns of inflammation that are more difficult to control post-operatively and who may benefit from other therapies.

Objective: determine if preoperative assessment of type and grade of inflammation and clinical factors can predict disease control with ESS plus long-term local corticosteroids in chronic rhinosinusitis with nasal polyps (CRSwNP).

Methods: Eighty patients treated with ESS plus mometasone-furoate 200 μg BID for CRSwNP and followed for at least 1 year were enrolled (November 2017-December 2018) in this prospective observational study. Read More

Head Neck Pathol 2020 Jun 19. Epub 2020 Jun 19.

Department of Pathology, Dartmouth-Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH, 03756, USA.

Thyroid carcinomas represent 3.2% of all new cases of cancer in the United States. Whereas most thyroid tumors arise from follicular cells or, less commonly, parafollicular cells, the derivation of some rare primary thyroid carcinoma subtypes is less clear and represents an area of evolving knowledge. Read More

Turk J Pediatr 2020 ;62(3):514-519

Department of Pediatric Allergy and Clinical Immunology, Health Sciences University Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.

Background: Eczema herpeticum (EH) is an acute disseminated viral infection that develops in the presence of an existing skin lesion, often on the ground of atopic dermatitis (AD). Morbidity and mortality of EH can be minimized by starting antiviral therapy at the earliest time in diagnosis.

Case: Herein we report five infants diagnosed with EH in the course of AD treatment. Read More

Clin Exp Dermatol 2020 Jun 17. Epub 2020 Jun 17.

Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

A 27-year old female presented with a 3 day history of fever, itchy maculopapular rash progressing cephalocaudally and facial swelling. She was a known case of multiple sclerosis (MS) taking oral teriflunomide 14 mg for past 27 days. She was not taking any other drug. Read More

Int J Dermatol 2020 Jun 18. Epub 2020 Jun 18.

Dermatology Department, Faculty of Medicine, Balamand University, Saint Georges Hospital UMC, Beirut, Lebanon.

Characterized chiefly by hypereosinophilia and angioedema, Gleich syndrome is a rare disorder with unclear clinical and therapeutic findings. Other symptoms include increased IgM levels, weight gain, fever, and urticaria. Herein we review Gleich syndrome and assess clinical features, epidemiology, and treatment options. Read More

Cardiovasc J Afr 2020 Jun 12;31:1-7. Epub 2020 Jun 12.

Department of Cardiology, China-Japan Union Hospital of Jilin University, Cardiovascular Institute of Jilin Province, Changchun 130033, Jilin Province, China.

Idiopathic hypereosinophilic syndrome (IHES) is a rare myeloproliferative disease characterised by multisystem dysfunction and persistent, extreme eosinophilia of unknown cause. Here we present a 42-year-old patient complaining of moderate to severe chest pain and shortness of breath, and typical ischaemic electrocardiography changes were recorded. He was initially suspected of having acute coronary syndrome, however the coronary angiogram excluded coronary abnormalities. Read More

Endocrinol Diabetes Metab Case Rep 2020 Jun 16;2020. Epub 2020 Jun 16.

Department of Hematology, Aichi Medical University School of Medicine, Nagakute, Japan.

Summary: Dupilumab an inhibitor of the interleukin (IL)-4R-alpha subunit is used for the treatment of allergic diseases. The patient was a 49-year-old man who received dupilumab for the treatment of severe atopic dermatitis. He presented hyperthyroidism with elevated thyroglobulin and anti-thyroid antibody negativity at 4 months after the initiation of therapy. Read More

Ann Allergy Asthma Immunol 2020 Jun 15. Epub 2020 Jun 15.

Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University, School of Medicine, Tokyo, Japan.

Background: Eosinophils in induced sputum are not only a useful biomarker for diagnosing asthma, but are also associated with severe asthma. However, little is known about the association between eosinophils in spontaneous sputum and asthma severity.

Objective: The aim of this study was to investigate whether spontaneous sputum eosinophils are related to severe asthma in adult asthmatic patients. Read More

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Jun;28(3):983-988

Department of Hematology, First Affiliated Hospital of Naval Military Medical University. Institute of Hematology of Chinese PLA, Shanghai 200433,

Objective: To study the potential significance and clinical application of FGFR1 gene abnormality in the diagnosis, clinical features, pathological mechanism and treatment in hematological tumors.

Methods: Clinical data of total of 29 patient with chromosome of 8 short arm (8P) abnormality who had more comprehensive medical history from 2013 to 2018 were collected. The karyotype analysis of bone marrow chromosomes in patients was carried out by using chromosome R band banding technique. Read More

Cureus 2020 May 16;12(5):e8152. Epub 2020 May 16.

Cardiology, Texas Tech University Health Sciences Center, Lubbock, USA.

Loeffler endocarditis is relatively under-recognized and can impose a diagnostic challenge. We present a case of Loeffler endocarditis where eosinophilia was associated with parasitosis. This case highlights the importance of clinical clues in a patient with restrictive cardiomyopathy, and appropriate ancillary testing which helps guide further management. Read More