3,091 results match your criteria Environmental Toxicology and Pharmacology [Journal]


Fine particulate matter (PM) enhances airway hyperresponsiveness (AHR) by inducing necroptosis in BALB/c mice.

Environ Toxicol Pharmacol 2019 Mar 12;68:155-163. Epub 2019 Mar 12.

Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China. Electronic address:

Objective: To observe the effects of prolonged exposure to high concentrations of PM on the trachea and lungs of mice and to determine whether the damages to the trachea and lung are induced by necroptosis.

Methods: Six- to eight-week-old female Balb/C mice of PM group were restrained in an animal restraining device using a nose-only "PM online enrichment system" for 8 weeks, in Shijiazhuang, Hebei, China. Anti -Fas group was exposed to PM inhalation and anti-Fas treatment via intranasal instillation. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.013DOI Listing

Oral exposure to cadmium and mercury alone and in combination causes damage to the lung tissue of Sprague-Dawley rats.

Environ Toxicol Pharmacol 2019 Mar 28;69:86-94. Epub 2019 Mar 28.

Department of Anatomy, Faculty of Health Sciences, University of Pretoria, Private Bag x323, Arcadia, 0007, South Africa. Electronic address:

Environmental presence and human exposure to heavy metals in air and cigarette smoke has led to a worldwide increase in respiratory disease. The effects of oral exposure to heavy metals in liver and kidney structure and function have been widely investigated and the respiratory system as a target is often overlooked. The aim of the study was to investigate the possible structural changes in the lung tissue of Sprague-Dawley rats after oral exposure for 28 days to cadmium (Cd) and mercury (Hg), alone and in combination at 1000 times the World Health Organization's limit for each metal in drinking water. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.021DOI Listing
March 2019
2 Reads

Toxicity effects of captan on different life stages of zebrafish (Danio rerio).

Environ Toxicol Pharmacol 2019 Apr 3;69:80-85. Epub 2019 Apr 3.

China Agricultural University, Beijing, 100193, China. Electronic address:

The objective of this study was to evaluate the toxicity and developmental effects of captan on different life stages (embryo and adult) of zebrafish (Danio rerio). The results showed that the 96-h lethal concentration 50 (LC) values of embryo and adult zebrafish (exposed to captan) were 0.81(0. Read More

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http://dx.doi.org/10.1016/j.etap.2019.04.003DOI Listing

Responses of biomarkers belonging to different metabolic systems of rats following oral administration of aluminium nanoparticle.

Environ Toxicol Pharmacol 2019 Apr 3;69:72-79. Epub 2019 Apr 3.

University of Cukurova, Faculty of Sciences and Arts, Department of Biology, Adana, Turkey.

Nanoparticle (NP) forms of aluminium oxide (AlO) are used in various fields such as engineering, pharmacy, medicine etc. Compounds containing aluminium oxide NPs may present toxic effects after certain thresholds. Thus, the present study was carried out to determine the effects of AlO nanoparticles (Al-NPs) in rats. Read More

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http://dx.doi.org/10.1016/j.etap.2019.04.002DOI Listing
April 2019
1 Read

The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells.

Environ Toxicol Pharmacol 2019 Apr 2;69:66-71. Epub 2019 Apr 2.

Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, People's Republic of China. Electronic address:

The therapeutic use of silk-derived materials such as fibroin in biomedicine is well-established in Southeast Asian countries. Studies indicated that silk fibroin (SF) peptide enhances insulin sensitivity and glucose metabolism phenomena associated with type 2 diabetes mellitus (T2DM) suggesting this peptide may be beneficial to treat this disease. However, the mechanisms underlying protective effect of SF in insulin-mediated hepatic metabolic dysfunction remains unclear. Read More

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http://dx.doi.org/10.1016/j.etap.2019.04.001DOI Listing
April 2019
1.862 Impact Factor

Polystyrene nanoplastics alter the cytotoxicity of human pharmaceuticals on marine fish cell lines.

Environ Toxicol Pharmacol 2019 Mar 29;69:57-65. Epub 2019 Mar 29.

Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

There is an increasing concern on the consequences of the presence of micro(nano)plastics to marine organisms. The present study aimed to provide information on the effects of polystyrene nanoplastics (PSNPs) to fish cells alone and combined with human pharmaceuticals, other emerging contaminants, using as biological models marine fish cell lines SAF-1 and DLB-1. Cells were exposed for 24 h to 100 nm PSNPs, starting at 0. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.019DOI Listing
March 2019
3 Reads

Human exposure to banned pesticides reported to the French Poison Control Centers: 2012-2016.

Environ Toxicol Pharmacol 2019 Mar 30;69:51-56. Epub 2019 Mar 30.

Centre antipoison de Paris, hôpital Fernand-Widal, Fédération de toxicologie FeTox, hôpital Lariboisière/Fernand-Widal, AP-HP, Inserm UMRS 1144, Paris, France.

In 2008, 30 active substances from plant protection products were banned from marketing in France. Nevertheless, the French Poison Control Centers continue to see cases of poisoning caused by these active substances that are no longer approved. The aim of this study was to describe the characteristics of the reported cases in mainland France and in overseas French territories, over the period 2012-2016. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.017DOI Listing
March 2019
3 Reads

Lycopene and resveratrol ameliorate zinc oxide nanoparticles-induced oxidative stress in Nile tilapia, Oreochromis niloticus.

Environ Toxicol Pharmacol 2019 Mar 18;69:44-50. Epub 2019 Mar 18.

Department of Hygiene, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.

Industrial products contained nano-zinc oxide (ZnONP) can gain access to the aquaculture environment causing hazardous effects on the living biota. Therefore, this work was planned to examine the ameliorative effects of dietary supplementation of lycopene (LYC) and/or resveratrol (RES) against ZnONP toxicity in Nile tilapia. Five groups with 20 fish each were used; Control, received tap water only; ZnONP group, was intoxicated with ZnONP (50 mg/L); ZnONP-LYC group, was exposed to ZnONP and LYC (500 mg/ kg of the diet); ZnONP-RES group, was exposed to ZnONP and RES (50 mg/kg of the diet); ZnONP-LYC-RES group, was exposed to ZnONP and a combination of LYC and RES. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.016DOI Listing
March 2019
2 Reads
1.862 Impact Factor

Lethality, neurotoxicity, morphological, histological and cellular alterations of Ni-Al nanoceramics on the embryo-larval development of Rhinella arenarum.

Environ Toxicol Pharmacol 2019 Mar 28;69:36-43. Epub 2019 Mar 28.

Instituto de Investigación e Ingeniería Ambiental-CONICET, Universidad Nacional de San Martin, Av. 25 de Mayo y Francia (1650), San Martín, Buenos Aires, Argentina; CONICET, Argentina. Electronic address:

Alumina nanoparticles (NP-AlO) are widely used but their environmental effects are unknown, so they can become potentially dangerous. The aim of this study was to evaluate the toxicity of a nanoceramic catalyst Ni/γ-AlO (NC) and NPs involved in their synthesis, γ-AlO support (SPC) and NiO/γ-AlO precursor (PC) on Rhinella arenarum embryo-larval development. The NPs toxicity significantly increased over time obtaining a similar sensitivity to PC and NC (336 h-LC50 = 4. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.020DOI Listing
March 2019
1 Read

Modulation of eNOS/iNOS by nebivolol protects against cyclosporine A-mediated nephrotoxicity through targeting inflammatory and apoptotic pathways.

Environ Toxicol Pharmacol 2019 Mar 21;69:26-35. Epub 2019 Mar 21.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61511 El-Minia, Egypt.

The aim of this study was to investigate effect of nitric oxide (NO) modulation on possible nephroprotective mechanisms of nebivolol (NEB) in cyclosporine A (CsA)-induced nephrotoxicity. Rats were treated with 20 mg/kg/day s.c. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.018DOI Listing

Chemosensitizer effect of cisplatin-treated bladder cancer cells by phenazine-5,10-dioxides.

Environ Toxicol Pharmacol 2019 Mar 19;69:9-15. Epub 2019 Mar 19.

Grupo de Química Medicinal, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay. Electronic address:

We determined the chemosensitizer effect of phenazine dioxide derivatives to cisplatin and the possible mechanism of action on bladder cancer cells. Anti-proliferative activity of nine phenazine dioxide derivatives in presence or absence of cisplatin was evaluated in two bladder tumor human cells T24 and 253 J and one non tumor cell line V79-4. The sensitizer effect of the combined treatment was determined by chromosomal aberrations and micronucleus test. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.015DOI Listing

Environmental inhibitors of the expression of cytochrome P450 17A1 in mammals.

Environ Toxicol Pharmacol 2019 Mar 14;69:16-25. Epub 2019 Mar 14.

The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 32500, China. Electronic address:

Cytochrome P450 17A1 (CYP17A1; EC: 1.14.14. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.007DOI Listing

Scrutinizing the interactions between bisphenol analogues and plasma proteins: Insights from biomimetic liquid chromatography, molecular docking simulations and in silico predictions.

Environ Toxicol Pharmacol 2019 Mar 9;68:148-154. Epub 2019 Mar 9.

Pharm-Analysis & Bio-Pharm Laboratory, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, I-80131, Naples, Italy; Consorzio Interuniversitario INBB, Viale Medaglie d'Oro, 305, I-00136, Rome, Italy. Electronic address:

The interactions between human serum albumin (HSA) and α- acid glycoprotein (AGP), the main plasma proteins binding drugs/xenobiotics, and some endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA) and some of its structural analogues, bisphenol S (BPS), bisphenol F (BPF), bisphenol E (BPE), bisphenol B (BPB), bisphenol AF (BPAF), bisphenol A diglycidyl ether (BADGE) and bisphenol M (BPM), were characterized by biomimetic liquid chromatography (LC). The interactions between bisphenols (BPs) and either HSA or AGP protein was found to be non-specific and essentially lipophilicity-driven. To get more information on the binding of BPs and plasma proteins, in silico predictions and molecular docking simulations were exploited, and the results achieved in silico were compared to those observed in vitro. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689193001
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http://dx.doi.org/10.1016/j.etap.2019.02.008DOI Listing
March 2019
5 Reads

Low doses of Bisphenol A have pro-inflammatory and pro-oxidant effects, stimulate lipid peroxidation and increase the cardiotoxicity of Doxorubicin in cardiomyoblasts.

Environ Toxicol Pharmacol 2019 Mar 7;69:1-8. Epub 2019 Mar 7.

Division of Cardiology, Istituto Nazionale Tumori- IRCCS- Fondazione Pascale, Napoli, Italy.

Endocrine disrupters are strictly associated to cancer and several cardiovascular risk factors. Bisphenol A (BPA) is an endocrine disrupter commonly used in the manufacturing of plastics based on polycarbonate, polyvinyl chloride and resins. Our study aims to investigate whether BPA may cause pro-oxidative and pro-inflammatory effects on cardiomyoblasts, thus exacerbating the Doxorubicin (DOXO)-induced cardiotoxicity phenomena. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.006DOI Listing

Microarray-based data mining reveals key genes and potential therapeutic drugs for Cadmium-induced prostate cell malignant transformation.

Environ Toxicol Pharmacol 2019 Mar 15;68:141-147. Epub 2019 Mar 15.

Institute of Cancer, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China. Electronic address:

Increasing evidence showed that Cadmium (Cd) can accumulate in the body and damage cells, resulting in cancerigenesis of the prostate with complex mechanisms. In the present study, we aimed to explore the possible key genes, pathways and therapeutic drugs using bioinformatics methods. Microarray-based data were retrieved and analyzed to screen differentially expressed genes (DEGs) between Cd-treated prostate cells and controls. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.014DOI Listing
March 2019
1 Read

Acute exposure to 4-OH-A, not PCB, alters brain aromatase activity but does not adversely affect growth in zebrafish.

Environ Toxicol Pharmacol 2019 Mar 14;68:133-140. Epub 2019 Mar 14.

Department of Biology, American University, Washington, DC, United States; Behavior, Cognition & Neuroscience Program, American University, Washington, DC, United States; Center for Behavioral Neuroscience, American University, Washington, DC, United States.

Acute developmental exposure to pharmaceuticals or environmental contaminants can have deleterious, long lasting effects. Many of these compounds are endocrine disruptors (EDCs) that target estrogen signaling, with effects on reproductive and non-reproductive tissues. We recently reported that zebrafish larvae transiently exposed to the pharmaceutical EDC 4-OH-A display visual deficits as adults. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.010DOI Listing

Cathepsin B mediated scramblase activation triggers cytotoxicity and cell cycle arrest by andrographolide to overcome cellular resistance in cisplatin resistant human hepatocellular carcinoma HepG2 cells.

Environ Toxicol Pharmacol 2019 Mar 5;68:120-132. Epub 2019 Mar 5.

UGC-HRDC, Jadavpur University, Kolkata, 700032 (Retd.), India. Electronic address:

Andrographolide regimen in single or in combination with anticancer drugs is a promising new strategy to reverse chemoresistance in heaptocellular carcinoma. Apoptosis inducing factor (AIF) may regulate a complementary, cooperative or redundant pathway, along with caspase cascades. Despite these findings, mechanisms underlying caspase-dependent and-independent signaling pathways in andrographolide -induced apoptosis in cisplatin-resistant human hepatocellular carcinoma cell line (HepG2CR) remain unclear. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.003DOI Listing
March 2019
1 Read
1.862 Impact Factor

Di(2-ethylhexyl) phthalate promotes hepatic fibrosis by regulation of oxidative stress and inflammation responses in rats.

Environ Toxicol Pharmacol 2019 Mar 8;68:109-119. Epub 2019 Mar 8.

Institute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine of Education Ministry, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei, 230032, Anhui, China. Electronic address:

Di(2-ethylhexyl) phthalate (DEHP) is an environmental pollutant that is widely used in medical and consumer products. An epidemiological study has suggested that a large daily intake of DEHP from phthalate-contaminated food may be a risk factor for liver dysfunction. Long-term exposure to DEHP is associated with liver disease and exacerbates the progression of chronic liver injury. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.008DOI Listing

Toxic effects of lead exposure on bioaccumulation, oxidative stress, neurotoxicity, and immune responses in fish: A review.

Environ Toxicol Pharmacol 2019 Mar 8;68:101-108. Epub 2019 Mar 8.

Fisheries Research & Development Institute, West Sea Fisheries Research Institute, National Institute of Fisheries Science, Taean, South Korea. Electronic address:

Lead (Pb) is a highly toxic metal in aquatic environments. Fish are at the top of the food chain in most aquatic environments, and are the most susceptible to the toxic effects of Pb exposure. In addition, fish are one of the most abundant vertebrates, and they can directly affect humans through food intake; therefore, fish can be used to assess the extent of environmental pollution in an aquatic environment. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.010DOI Listing
March 2019
4 Reads

Influence of humic substances on the toxic effects of cadmium and SDBS to the green alga Scenedesmus obliquus.

Environ Toxicol Pharmacol 2019 Mar 11;68:94-100. Epub 2019 Mar 11.

Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Dalian, 116024, China.

The joint toxicity of chemicals mixture in the aquatic environment was still not well clear. To clarify the joint toxicity of the mixtures of metals and organic pollutants, as well as the influence of dissolved organic matter (DOM) in field water-body on their toxic effects, we conducted the toxicity tests with cadmium (Cd) and sodium dodecyl benzene sulfonate (SDBS) on Scenedesmus obliquus (S. obliquus) with or without the presence of fulvic acid (FA), a typical of DOM. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.012DOI Listing
March 2019
1 Read

Death of captive-bred vultures caused by flunixin poisoning in Italy.

Environ Toxicol Pharmacol 2019 Mar 11;68:91-93. Epub 2019 Mar 11.

Istituto Zooprofilattico Sperimentale del Lazio e della Toscana "M. Aleandri", Via Appia Nuova 1411, 00178 Rome, Italy. Electronic address:

Among non steroidal anti-inflammatory drugs (NSAIDs) diclofenac is considered the main cause for the decline of vulture populations in the Indian subcontinent since the '90 s. Chemical analysis showed high levels of flunixin (31,350 μg/kg) in beef which three captive Gyps vultures fed on, later dying with severe visceral gout. Levels in dead vultures' organs and tissues ranged from 4 to 38. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.011DOI Listing
March 2019
1 Read

Hydrogen sulfide ameliorates disorders in the parafacial respiratory group region of neonatal rats caused by prenatal cigarette smoke exposure via an antioxidative effect.

Environ Toxicol Pharmacol 2019 Mar 4;68:80-90. Epub 2019 Mar 4.

Department of Physiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041 Sichuan, PR China. Electronic address:

We previously found that hydrogen sulfide (HS) ameliorated the dysfunction of central chemoreception caused by prenatal cigarette smoke exposure (CSE). In the present study, we further explored whether the parafacial respiratory group (pFRG) is involved in the protection of central chemoreception by HS against prenatal CSE-induced injury. We found that NaHS, a donor of HS, restored the expression of Phox2b, which was downregulated by prenatal CSE, in the pFRG region of neonatal rats. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.002DOI Listing
March 2019
1.862 Impact Factor

Microplastics in cosmetics: Environmental issues and needs for global bans.

Environ Toxicol Pharmacol 2019 Mar 8;68:75-79. Epub 2019 Mar 8.

Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (CSGI), University of Florence, Via della Lastruccia 3, Sesto Fiorentino, 50019, FI, Italy; Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 3, Sesto Fiorentino, 50019, FI, Italy.

Despite the microbeads from cosmetic products do not contribute with high percentages to the microplastic pollution, they can pose a threat to the environment, being discharged into the water bodies and just partially blocked by the wastewater treatment plants. As environmental associations have been fighting for the abolition of microplastics in PCCPs, in many countries measures have been taken and bans are already operational or in process. Some cosmetic companies have voluntarily renounced the use of microbeads and some voluntary certifications of PCCPs prohibit their use. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.007DOI Listing
March 2019
1 Read

Microplastics in the marine environment: Current trends in environmental pollution and mechanisms of toxicological profile.

Environ Toxicol Pharmacol 2019 Mar 8;68:61-74. Epub 2019 Mar 8.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Viale Ferdinando Stagno d'Alcontres 31 98166, S Agata, Messina, Italy. Electronic address:

The global plastics production has increased from 1.5 million tons in the 1950s to 335 million tons in 2016, with plastics discharged into virtually all components of the environment. Plastics rarely biodegrade but through different processes they fragment into microplastics and nanoplastics, which have been reported as ubiquitous pollutants in all marine environments worldwide. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.001DOI Listing
March 2019
2 Reads

Melatonin alleviates β-zearalenol and HT-2 toxin-induced apoptosis and oxidative stress in bovine ovarian granulosa cells.

Environ Toxicol Pharmacol 2019 Mar 7;68:52-60. Epub 2019 Mar 7.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China. Electronic address:

β-zearalenol (β-zol) and HT-2 are mycotoxins which cause apoptosis and oxidative stress in mammalian reproductive cells. Melatonin is an endogenous antioxidant involved in apoptosis and oxidative stress-related activities. This study investigated the effects of β-zol and HT-2 on bovine ovarian granulosa cells (BGCs), and how melatonin may counteract these effects. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.005DOI Listing

Microplastic exposure and effects in aquatic organisms: A physiological perspective.

Environ Toxicol Pharmacol 2019 Mar 8;68:37-51. Epub 2019 Mar 8.

Animal and Environmental Physiology Laboratory, Department of Biological, Geological and Environmental Sciences (BIGEA), University of Bologna, Ravenna, Italy.

The impact of microplastics (MPs) on aquatic life, given their ubiquitous presence in the water compartment, represents a growing concern. Consistently, scientific knowledge is advancing rapidly, although evidence on actual adverse effects is still highly fragmented. This paper summarizes the recent literature on MP impacts on aquatic organisms in an attempt to link routes of uptake, possible alterations of physiological processes, and outcomes at different levels of biological organization. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.009DOI Listing
March 2019
2 Reads

Effects of the chronic exposure to cerium dioxide nanoparticles in Oncorhynchus mykiss: Assessment of oxidative stress, neurotoxicity and histological alterations.

Environ Toxicol Pharmacol 2019 Feb 23;68:27-36. Epub 2019 Feb 23.

Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal; Centro de Estudos do Ambiente e do Mar (CESAM), Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal. Electronic address:

Cerium dioxide nanoparticles (CeO-NPs) have a variety of uses, especially in the production of solar panels, oxygen pumps, gas sensors, computer chips and catalytic converters. Despite their worldwide use, the few published studies demonstrate that metallic nanoparticles, in general, are still not properly characterized in terms of their potencial ecotoxicological effects. CeO-NPs, in particular, have demonstrated extreme antioxidant activity, but their in vivo toxicity is still unknown. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.012DOI Listing
February 2019

Bioaccumulation of decabromodiphenyl ether affects the antioxidant system in the clam Mactra veneriformis.

Environ Toxicol Pharmacol 2019 Mar 4;68:19-26. Epub 2019 Mar 4.

School of Agriculture, Ludong University, Yantai, 264025, China. Electronic address:

Antioxidant enzymes play vital roles against oxidative stress induced by decabromodiphenyl ether (BDE-209), being widespread in marine environment. However, the effect of BDE-209 on antioxidant enzymes remains poorly understood in marine bivalves. In this study, the clams Mactra veneriformis were exposed to 0. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.004DOI Listing
March 2019
12 Reads

Anti-inflammatory and analgesic activity based on polymorphism of cedrol in mice.

Environ Toxicol Pharmacol 2019 Feb 13;68:13-18. Epub 2019 Feb 13.

Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Key Laboratory of Structure-based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address:

Alternate forms of drug crystals display different physicochemical properties. These include stability, dissolution rate, bioavailability and solubility, which can affect pharmacokinetics and pharmacodynamics. It is therefore important to compare the crystal forms of cedrol to obtain optimal anti-inflammatory and analgesic effects. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.005DOI Listing
February 2019
3 Reads
1.862 Impact Factor

Nano-eco toxicity study of gold nanoparticles on aquatic organism Moina macrocopa: As new versatile ecotoxicity testing model.

Environ Toxicol Pharmacol 2019 Feb 22;68:4-12. Epub 2019 Feb 22.

Food Engineering and Technology Department, Institute of Chemical Technology, Mumbai, 400019, Maharashtra, India.

In the field of nanoecotoxicology, very few reports have focused on biochemical changes in non-target organisms after nanoexposure. A less explored aquatic non-target crustacean, Moina macrocopa, was used in the present study to analyze toxicity effects of gold nanoparticles (AuNPs), an emerging nanomaterial. AuNPs was fabricated using tannic acid and were 29 ± 2 nm in size. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.013DOI Listing
February 2019

Differential toxicity of water versus gavage exposure to trichloroethylene in rats.

Environ Toxicol Pharmacol 2019 Feb 16;68:1-3. Epub 2019 Feb 16.

Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street Rm. 510, Box G-E5, Providence, Rhode Island, 02912, United States.

Trichloroethylene (TCE) is a persistent environmental contaminant that causes male reproductive toxicity. We investigated whether transient increases in TCE exposure modulated male reproductive toxicity by exposing rats via daily oral to repeated gavage exposures (1000 mg/kg/day) and through drinking water (0.6% TCE) for 14 weeks. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.003DOI Listing
February 2019

The neuroprotective effect of hyperoxygenate hydrogen-rich saline on CO-induced brain injury in rats.

Environ Toxicol Pharmacol 2019 Apr 19;67:117-123. Epub 2019 Feb 19.

Department of Biomedical engineering, Fourth Military Medical University, Xi'an, China. Electronic address:

This study was designed to investigate the neuroprotective effect of hyperoxygenate hydrogen-rich saline (HOHS) against brain injury induced by carbon monoxide (CO) poisoning in rats. A rat model of CO poisoning was established by administering CO via intraperitoneal injection to male Sprague-Dawley rats. Forty-eight adult male rats were randomly divided into the following groups: normal control group (NG), CO poisoning group (CO), HOS treatment group (hyperoxygenated solution, HOS) and HOHS treatment group (HOHS). Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.011DOI Listing
April 2019
4 Reads
1.862 Impact Factor

Identification and characterization of novel bacterial polyaromatic hydrocarbon-degrading enzymes as potential tools for cleaning up hydrocarbon pollutants from different environmental sources.

Environ Toxicol Pharmacol 2019 Apr 20;67:108-116. Epub 2019 Feb 20.

Department of Genetics Faculty of Agriculture, Cairo University, PO Box 12613 Giza, Egypt. Electronic address:

Polycyclic aromatic hydrocarbons (PAHs) are recalcitrant hazardous environmental contaminants. Various strategies, including chemical and physical like oxidation, fixation, leaching, and electrokinetic or biological-based techniques are used for remediation of polluted sites. Bioremediation of PAHs, via PAH-degrading endophytic and rhizospheric microbes, represent a time-/cost-effective way for ecorestoration. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.009DOI Listing
April 2019
1 Read

Cadmium: Toxic effects on placental and embryonic development.

Environ Toxicol Pharmacol 2019 Apr 15;67:102-107. Epub 2019 Feb 15.

Institute of Chronic Disease Risks Assessment, School of Nursing and Health Sciences, Henan University, Kaifeng, 475004, Henan Province, PR China. Electronic address:

Cadmium is a non-essential trace metal that has strong teratogenic and mutagenic effects in living organisms. The content is more highly enriched in women than in men and can enter the embryo through the placenta and destroy the placenta's morphological structure, resulting in fetal growth restriction. In this report, we review published data linking pregnancy exposure to cadmium to placenta and fetal growth and development toxicity and summarize the related mechanisms. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.006DOI Listing
April 2019
1 Read

The analysis of the possibility of using biological tests for assessment of toxicity of leachate from an active municipal landfill.

Environ Toxicol Pharmacol 2019 Apr 11;67:94-101. Epub 2019 Feb 11.

Engineering Institute, State University of Applied Sciences in Nowy Sącz, Zamenhofa 1a St., 33-300, Nowy Sącz, Poland. Electronic address:

One of the consequence of municipal waste deposition is the production of landfill leachate. Its volume and composition is determined by numerous factors, including waste composition, landfill age and the volume of precipitation. Leachate may contain a number of mineral and organic compounds, the volume of which must be controlled regularly. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.013DOI Listing

Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure.

Environ Toxicol Pharmacol 2019 Apr 6;67:87-93. Epub 2019 Feb 6.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98166, Agata-Messina, Italy. Electronic address:

The purpose of our experiment was to evaluate the effect of enrofloxacin on biotransformation, oxidative stress and mRNA expression of related genes in fish as a non-target organisms. Zebrafish (Danio rerio) juveniles were treated with enrofloxacin at concentrations of 5, 10 and 500 μg/L for 14 days. A three-day-long test caused changes of catalytic activity of glutathione peroxidase and glutathione-S-transferase. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.002DOI Listing
April 2019
8 Reads

Circulating miRNA-126, -145 and -155 levels in Mexican women exposed to inorganic arsenic via drinking water.

Environ Toxicol Pharmacol 2019 Apr 7;67:79-86. Epub 2019 Feb 7.

Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí, Rio-verde, San Luis Potosí, Mexico. Electronic address:

The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.004DOI Listing

Toxic effects of nitrogenous compounds (ammonia, nitrite, and nitrate) on acute toxicity and antioxidant responses of juvenile olive flounder, Paralichthys olivaceus.

Environ Toxicol Pharmacol 2019 Apr 2;67:73-78. Epub 2019 Feb 2.

National Institute of Fisheries Science, West Sea Fisheries Research Institute, Fisheries Research & Devlopment Institute, Taean, 32132, Republic of Korea.

Juvenile Paralichthys olivaceus (mean length 7.29 ± 0.59 cm, mean weight 2. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.001DOI Listing
April 2019
3 Reads

Cypermethrin-based formulation Barrage induces histological changes in gills of the Pantanal endemic shrimp Macrobrachium pantanalense.

Environ Toxicol Pharmacol 2019 Apr 30;67:66-72. Epub 2019 Jan 30.

Programa de Pós-Graduação em Zootecnia, Universidade Estadual de Mato Grosso do Sul, Unidade Universitária de Aquidauana, Rodovia Aquidauana-UEMS Km 12, Cx Postal 25- CEP, 79200-000, Aquidauana, MS, Brazil.

Pantanal shrimp Macrobrachium pantanalense was exposed for 96 h to the cypermethrin-based formulation Barrage. Population-relevant endpoints (survival, swimming behavior) as well as histopathology of gills were analyzed. A 96 h-LC of 0. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.014DOI Listing
April 2019
1 Read

Gills CYP1A of Oncorhynchus mykiss as a sensitive biomarker of crude oil pollution in freshwater environments.

Environ Toxicol Pharmacol 2019 Apr 21;67:61-65. Epub 2019 Jan 21.

INIBIOMA - CONICET, Argentina.

The induction of CYP1A activity (EROD) and protein expression was compared in liver and gills of rainbow trout from a stream polluted with crude oil, and through laboratory exposures to 1% and 5% of water accommodated fraction of the crude oil (WAF) for 1 and 4 days. Gills EROD increased 1.6-2. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.008DOI Listing

Effects of perinatal di (2-ethylhexyl) phthalate exposure on thyroid function in rat offspring.

Environ Toxicol Pharmacol 2019 Apr 25;67:53-60. Epub 2019 Jan 25.

Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, People's Republic of China. Electronic address:

Di (2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer in industry and displays the characteristics of an endocrine disruptor. Disorders of the maternal thyroid hormone (TH) during pregnancy can cause adverse effects on the fetus. We investigated the effects and possible mechanism of perinatal DEHP exposure on the thyroid function of pups. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.012DOI Listing
April 2019
1 Read

Antioxidant imbalance and genotoxicity detected in fish induced by titanium dioxide nanoparticles (NpTiO) and inorganic lead (PbII).

Environ Toxicol Pharmacol 2019 Apr 28;67:42-52. Epub 2019 Jan 28.

Department of Genetics, Laboratory of Animal Cytogenetics and Environmental Mutagenesis, Federal University of Paraná (UFPR), Curitiba, Paraná, Brazil.

Titanium dioxide nanoparticles (NpTiO) are the most widely-used nanoparticle type and the adsorption of metals such as lead (PbII) onto their surface is a major source of concern to scientists. This study evaluated the effects of the associated exposure to both types of contaminant, i.e. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.009DOI Listing
April 2019
2 Reads

Microplastics occurrence in the Tyrrhenian waters and in the gastrointestinal tract of two congener species of seabreams.

Environ Toxicol Pharmacol 2019 Apr 25;67:35-41. Epub 2019 Jan 25.

Department of Biomedical, Dental and Morphological and Functional Imaging, Italy.

In this work it is reported for the first time the characterization of microplastics from sea water samples and in two congener species of seabreams: Pagellus erythrinus and P. bogaraveo, Mediterranean fish species of great commercial importance. An experimental survey was conducted on May-June 2017 in the southernmost part of the Tyrrhenian Sea. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.011DOI Listing
April 2019
1 Read

Mechanisms of engineered nanoparticle induced neurotoxicity in Caenorhabditis elegans.

Environ Toxicol Pharmacol 2019 Apr 22;67:29-34. Epub 2019 Jan 22.

Department of Physiology, Faculty of Medicine, University of Thessaly, BIOPOLIS, Larissa, 41500, Greece. Electronic address:

The wide-spread implementation of nanoparticles poses a major health concern. Unique biokinetics allow them to transfer to neurons throughout the body and inflict neurotoxicity, which is challenging to evaluate solely in mammalian experimental models due to logistics, financial and ethical limitations. In recent years, the nematode Caenorhabditis elegans has emerged as a promising nanotoxicology experimental surrogate due to characteristics such as ease of culture, short life cycle and high number of progeny. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.010DOI Listing

Ecotoxicological effects on Scenedesmus obliquus and Danio rerio Co-exposed to polystyrene nano-plastic particles and natural acidic organic polymer.

Environ Toxicol Pharmacol 2019 Apr 22;67:21-28. Epub 2019 Jan 22.

College of Environmental Science and Engineering, Dalian Maritime University, Dalian 116026, PR China.

The importance of attention to unravel the interaction of nano-plastic particles (NPs) with natural acidic organic polymer (NAOP) in freshwater environment should not be neglected. However, toxicological data available for the interaction between NPs and NAOP remain limited. Here, we investigate the toxicological effects of three model polystyrene (PS) NPs with different functional groups (unmodified, amino- and carboxyl-modified PS NPs) on two freshwater organisms of different trophic levels (Scenedesmus obliquus and Danio rerio) in the absence and presence of two classes of NAOP, namely fulvic acid and humic acid. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.007DOI Listing

Lung effects of 7- and 28-day inhalation exposure of rats to emissions from 1st and 2nd generation biodiesel fuels with and without particle filter - The FuelHealth project.

Environ Toxicol Pharmacol 2019 Apr 18;67:8-20. Epub 2019 Jan 18.

Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Norway. Electronic address:

Increased use of 1st and 2nd generation biofuels raises concerns about health effects of new emissions. We analyzed cellular and molecular lung effects in Fisher 344 rats exposed to diesel engine exhaust emissions (DEE) from a Euro 5-classified diesel engine running on B7: petrodiesel fuel containing 7% fatty acid methyl esters (FAME), or SHB20 (synthetic hydrocarbon biofuel): petrodiesel fuel containing 7% FAME and 13% hydrogenated vegetable oil. The Fisher 344 rats were exposed for 7 consecutive days (6 h/day) or 28 days (6 h/day, 5 days/week), both with and without diesel particle filter (DPF) treatment of the exhaust in whole body exposure chambers (n = 7/treatment). Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.005DOI Listing
April 2019
9 Reads

Nanoplastics and marine organisms: What has been studied?

Environ Toxicol Pharmacol 2019 Apr 21;67:1-7. Epub 2019 Jan 21.

Department of Biology & CESAM, Campus de Santiago, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address:

Nowadays, there is an increased awareness on the threat that marine litter may pose to the marine environment. This review describes the major concerns related to plastic pollution, namely in terms of toxicity of different types and sizes of nanoplastics (particles smaller than 100 nm) to marine organisms, either producers or consumers. The available data show that nanoplastics may affect negatively organisms from different phyla with reported effects ranging from alterations in reproduction to lethality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183056
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http://dx.doi.org/10.1016/j.etap.2019.01.006DOI Listing
April 2019
8 Reads

Modulation of homologous recombination repair gene polymorphisms on genetic damage in chromate exposed workers.

Environ Toxicol Pharmacol 2019 Feb 16;66:126-132. Epub 2019 Jan 16.

Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, 100191, PR China. Electronic address:

Hexavalent chromium [Cr(VI)] is one of the most common environmental carcinogens, which is associated with DNA damage, genetic instability and increase the risk of cancer development. However, the mechanisms of genetic damage induced by Cr(VI) remains to be thoroughly illustrated. A molecular epidemiological study was conducted on 120 chromate exposed workers and 97 controls. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.004DOI Listing
February 2019
2 Reads

Corrigendum to "Pollution in drinking water source areas: Microplastics in the Danjiangkou Reservoir, China" [Environ. Toxicol. Pharmacol. 65 (January) 2019 82-89].

Environ Toxicol Pharmacol 2019 Feb 18;66:133. Epub 2019 Jan 18.

Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; Sino-Africa Joint Research Center, Chinese Academy of Sciences, Wuhan, 430074, China. Electronic address:

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http://dx.doi.org/10.1016/j.etap.2019.01.002DOI Listing
February 2019

Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses.

Environ Toxicol Pharmacol 2019 Feb 14;66:116-125. Epub 2019 Jan 14.

National Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark; Department of Micro- and Nanotechnology, Danish Technical University (DTU), DK-2800, Kgs., Lyngby, Denmark. Electronic address:

We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE NFC, 2-20 μm in length, 2-15 nm in width, 2) AS (-COOH), carboxylated, 0.5-10 μm in length, 4-10 nm in width, containing the biocide BIM MC4901 and 3) BIOCID FINE NFC: as (1) but containing BIM MC4901. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.003DOI Listing
February 2019
2 Reads
1.862 Impact Factor