3,056 results match your criteria Environmental Toxicology and Pharmacology [Journal]


Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure.

Environ Toxicol Pharmacol 2019 Feb 6;67:87-93. Epub 2019 Feb 6.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98166, Agata-Messina, Italy. Electronic address:

The purpose of our experiment was to evaluate the effect of enrofloxacin on biotransformation, oxidative stress and mRNA expression of related genes in fish as a non-target organisms. Zebrafish (Danio rerio) juveniles were treated with enrofloxacin at concentrations of 5, 10 and 500 μg/L for 14 days. A three-day-long test caused changes of catalytic activity of glutathione peroxidase and glutathione-S-transferase. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.002DOI Listing
February 2019

Circulating miRNA-126, -145 and -155 levels in Mexican women exposed to inorganic arsenic via drinking water.

Environ Toxicol Pharmacol 2019 Feb 7;67:79-86. Epub 2019 Feb 7.

Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí, Rio-verde, San Luis Potosí, Mexico. Electronic address:

The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.004DOI Listing
February 2019

Toxic effects of nitrogenous compounds (ammonia, nitrite, and nitrate) on acute toxicity and antioxidant responses of juvenile olive flounder, Paralichthys olivaceus.

Environ Toxicol Pharmacol 2019 Feb 2;67:73-78. Epub 2019 Feb 2.

National Institute of Fisheries Science, West Sea Fisheries Research Institute, Fisheries Research & Devlopment Institute, Taean, 32132, Republic of Korea.

Juvenile Paralichthys olivaceus (mean length 7.29 ± 0.59 cm, mean weight 2. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.001DOI Listing
February 2019

Cypermethrin-based formulation Barrage induces histological changes in gills of the Pantanal endemic shrimp Macrobrachium pantanalense.

Environ Toxicol Pharmacol 2019 Jan 30;67:66-72. Epub 2019 Jan 30.

Programa de Pós-Graduação em Zootecnia, Universidade Estadual de Mato Grosso do Sul, Unidade Universitária de Aquidauana, Rodovia Aquidauana-UEMS Km 12, Cx Postal 25- CEP, 79200-000, Aquidauana, MS, Brazil.

Pantanal shrimp Macrobrachium pantanalense was exposed for 96 h to the cypermethrin-based formulation Barrage. Population-relevant endpoints (survival, swimming behavior) as well as histopathology of gills were analyzed. A 96 h-LC of 0. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.014DOI Listing
January 2019

Gills CYP1A of Oncorhynchus mykiss as a sensitive biomarker of crude oil pollution in freshwater environments.

Environ Toxicol Pharmacol 2019 Jan 21;67:61-65. Epub 2019 Jan 21.

INIBIOMA - CONICET, Argentina.

The induction of CYP1A activity (EROD) and protein expression was compared in liver and gills of rainbow trout from a stream polluted with crude oil, and through laboratory exposures to 1% and 5% of water accommodated fraction of the crude oil (WAF) for 1 and 4 days. Gills EROD increased 1.6-2. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.008DOI Listing
January 2019

Effects of perinatal di (2-ethylhexyl) phthalate exposure on thyroid function in rat offspring.

Environ Toxicol Pharmacol 2019 Jan 25;67:53-60. Epub 2019 Jan 25.

Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, People's Republic of China. Electronic address:

Di (2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer in industry and displays the characteristics of an endocrine disruptor. Disorders of the maternal thyroid hormone (TH) during pregnancy can cause adverse effects on the fetus. We investigated the effects and possible mechanism of perinatal DEHP exposure on the thyroid function of pups. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.012DOI Listing
January 2019
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Antioxidant imbalance and genotoxicity detected in fish induced by titanium dioxide nanoparticles (NpTiO) and inorganic lead (PbII).

Environ Toxicol Pharmacol 2019 Jan 28;67:42-52. Epub 2019 Jan 28.

Department of Genetics, Laboratory of Animal Cytogenetics and Environmental Mutagenesis, Federal University of Paraná (UFPR), Curitiba, Paraná, Brazil.

Titanium dioxide nanoparticles (NpTiO) are the most widely-used nanoparticle type and the adsorption of metals such as lead (PbII) onto their surface is a major source of concern to scientists. This study evaluated the effects of the associated exposure to both types of contaminant, i.e. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.009DOI Listing
January 2019
1 Read

Microplastics occurrence in the Tyrrhenian waters and in the gastrointestinal tract of two congener species of seabreams.

Environ Toxicol Pharmacol 2019 Jan 25;67:35-41. Epub 2019 Jan 25.

Department of Biomedical, Dental and Morphological and Functional Imaging, Italy.

In this work it is reported for the first time the characterization of microplastics from sea water samples and in two congener species of seabreams: Pagellus erythrinus and P. bogaraveo, Mediterranean fish species of great commercial importance. An experimental survey was conducted on May-June 2017 in the southernmost part of the Tyrrhenian Sea. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.011DOI Listing
January 2019
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Mechanisms of engineered nanoparticle induced neurotoxicity in Caenorhabditis elegans.

Environ Toxicol Pharmacol 2019 Jan 22;67:29-34. Epub 2019 Jan 22.

Department of Physiology, Faculty of Medicine, University of Thessaly, BIOPOLIS, Larissa, 41500, Greece. Electronic address:

The wide-spread implementation of nanoparticles poses a major health concern. Unique biokinetics allow them to transfer to neurons throughout the body and inflict neurotoxicity, which is challenging to evaluate solely in mammalian experimental models due to logistics, financial and ethical limitations. In recent years, the nematode Caenorhabditis elegans has emerged as a promising nanotoxicology experimental surrogate due to characteristics such as ease of culture, short life cycle and high number of progeny. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.010DOI Listing
January 2019

Ecotoxicological effects on Scenedesmus obliquus and Danio rerio Co-exposed to polystyrene nano-plastic particles and natural acidic organic polymer.

Environ Toxicol Pharmacol 2019 Jan 22;67:21-28. Epub 2019 Jan 22.

College of Environmental Science and Engineering, Dalian Maritime University, Dalian 116026, PR China.

The importance of attention to unravel the interaction of nano-plastic particles (NPs) with natural acidic organic polymer (NAOP) in freshwater environment should not be neglected. However, toxicological data available for the interaction between NPs and NAOP remain limited. Here, we investigate the toxicological effects of three model polystyrene (PS) NPs with different functional groups (unmodified, amino- and carboxyl-modified PS NPs) on two freshwater organisms of different trophic levels (Scenedesmus obliquus and Danio rerio) in the absence and presence of two classes of NAOP, namely fulvic acid and humic acid. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.007DOI Listing
January 2019

Lung effects of 7- and 28-day inhalation exposure of rats to emissions from 1st and 2nd generation biodiesel fuels with and without particle filter - The FuelHealth project.

Environ Toxicol Pharmacol 2019 Jan 18;67:8-20. Epub 2019 Jan 18.

Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Norway. Electronic address:

Increased use of 1st and 2nd generation biofuels raises concerns about health effects of new emissions. We analyzed cellular and molecular lung effects in Fisher 344 rats exposed to diesel engine exhaust emissions (DEE) from a Euro 5-classified diesel engine running on B7: petrodiesel fuel containing 7% fatty acid methyl esters (FAME), or SHB20 (synthetic hydrocarbon biofuel): petrodiesel fuel containing 7% FAME and 13% hydrogenated vegetable oil. The Fisher 344 rats were exposed for 7 consecutive days (6 h/day) or 28 days (6 h/day, 5 days/week), both with and without diesel particle filter (DPF) treatment of the exhaust in whole body exposure chambers (n = 7/treatment). Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.005DOI Listing
January 2019
3 Reads

Nanoplastics and marine organisms: What has been studied?

Environ Toxicol Pharmacol 2019 Jan 21;67:1-7. Epub 2019 Jan 21.

Department of Biology & CESAM, Campus de Santiago, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address:

Nowadays, there is an increased awareness on the threat that marine litter may pose to the marine environment. This review describes the major concerns related to plastic pollution, namely in terms of toxicity of different types and sizes of nanoplastics (particles smaller than 100 nm) to marine organisms, either producers or consumers. The available data show that nanoplastics may affect negatively organisms from different phyla with reported effects ranging from alterations in reproduction to lethality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183056
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http://dx.doi.org/10.1016/j.etap.2019.01.006DOI Listing
January 2019
2 Reads

Modulation of homologous recombination repair gene polymorphisms on genetic damage in chromate exposed workers.

Environ Toxicol Pharmacol 2019 Feb 16;66:126-132. Epub 2019 Jan 16.

Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, 100191, PR China. Electronic address:

Hexavalent chromium [Cr(VI)] is one of the most common environmental carcinogens, which is associated with DNA damage, genetic instability and increase the risk of cancer development. However, the mechanisms of genetic damage induced by Cr(VI) remains to be thoroughly illustrated. A molecular epidemiological study was conducted on 120 chromate exposed workers and 97 controls. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.004DOI Listing
February 2019
2 Reads

Corrigendum to "Pollution in drinking water source areas: Microplastics in the Danjiangkou Reservoir, China" [Environ. Toxicol. Pharmacol. 65 (January) 2019 82-89].

Environ Toxicol Pharmacol 2019 Feb 18;66:133. Epub 2019 Jan 18.

Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; Sino-Africa Joint Research Center, Chinese Academy of Sciences, Wuhan, 430074, China. Electronic address:

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http://dx.doi.org/10.1016/j.etap.2019.01.002DOI Listing
February 2019

Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses.

Environ Toxicol Pharmacol 2019 Feb 14;66:116-125. Epub 2019 Jan 14.

National Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark; Department of Micro- and Nanotechnology, Danish Technical University (DTU), DK-2800, Kgs., Lyngby, Denmark. Electronic address:

We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE NFC, 2-20 μm in length, 2-15 nm in width, 2) AS (-COOH), carboxylated, 0.5-10 μm in length, 4-10 nm in width, containing the biocide BIM MC4901 and 3) BIOCID FINE NFC: as (1) but containing BIM MC4901. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.003DOI Listing
February 2019
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Daurinoline suppressed the migration and invasion of chemo-resistant human non-small cell lung cancer cells by reversing EMT and Notch-1 and sensitized the cells to Taxol.

Environ Toxicol Pharmacol 2019 Feb 6;66:109-115. Epub 2018 Dec 6.

Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China; Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Non-small cell lung cancer (NSCLC) is one of the most common malignancies, and Taxol is a cornerstone in the treatment. However, taxol-resistance eventually limits the clinical effects and applications. Daurinoline could restore the sensitivity of resistant MCF-7/adr and KBv200 cells. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.005DOI Listing
February 2019
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Evaluation of genetic polymorphisms in MMP2, MMP9 and MMP20 in Brazilian children with dental fluorosis.

Environ Toxicol Pharmacol 2019 Feb 21;66:104-108. Epub 2018 Dec 21.

Department of Pediatric Dentistry, Ribeirão Preto Dental School, USP - University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address:

Recent studies suggested that genetics contribute to differences in dental fluorosis (DF) susceptibility among individuals having the same environmental exposure. This study evaluated if MMP2, MMP9 and MMP20 are expressed during enamel development and assessed the association between polymorphisms in these genes with DF. Mice susceptible and resistant to DF were used to evaluate if MMPs were candidate genes for DF. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.016DOI Listing
February 2019

Short-term exposure to carbamazepine causes oxidative stress on common carp (Cyprinus carpio).

Environ Toxicol Pharmacol 2019 Feb 21;66:96-103. Epub 2018 Dec 21.

Laboratory of Environmental Toxicology, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón intersección Paseo Tollocan s/n. Col. Residencial Colón, 50120, Toluca, Estado de México, Mexico.

The aim of this research was to determine the bioconcentration factor and if subacute exposure to carbamazepine (2 mg L) modifies the oxidative state of liver, gills and brain of Cyprinus carpio. This was measured through the following biomarkers: hydroperoxide and protein carbonyl content, lipid peroxidation degree, as well as superoxide dismutase, catalase and glutathione peroxidase activity. Carbamazepine concentration in carp's tissue was also determined by liquid chromatography with a diode arrangement detector. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.017DOI Listing
February 2019
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A comparative study on influences of static electric field and power frequency electric field on cognition in mice.

Environ Toxicol Pharmacol 2019 Feb 4;66:91-95. Epub 2019 Jan 4.

Institute of Environmental Process, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, PR China.

Recently, electromagnetic fields around ultra-high voltage transmission lines have received considerable attentions for their potential biological effects. This study aimed to investigate the effects of static electric field (SEF) and power frequency electric field (PFEF) on cognition. Mice were exposed to SEF and PFEF with the same strength (35 kV/m) for 49 days, respectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689193000
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http://dx.doi.org/10.1016/j.etap.2019.01.001DOI Listing
February 2019
5 Reads

Investigation of the differential transport mechanism of cinnabar and mercury containing compounds.

Environ Toxicol Pharmacol 2019 Feb 26;66:83-90. Epub 2018 Dec 26.

Joint International Research Laboratory of Ethnomedicine, Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical College, Guizhou, China. Electronic address:

Background: Cinnabar has a long history of uses in Chinese traditional medicines as an ingredient in various remedies. However, the detailed mechanism of cinnabar in medication remains unclear, and the toxicity of cinnabar has been a debate due to its containing mercury sulfide. This study was designed to investigate the differential transport mechanism of cinnabar and other Hg-containing compounds HgCl, MeHg and HgS, and to determine if organic anion transporters OAT1 and OAT3 were involved in the differential transport mechanism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183058
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http://dx.doi.org/10.1016/j.etap.2018.12.020DOI Listing
February 2019
5 Reads

Temperature affects the toxicity of lead-contaminated food in Geophagus brasiliensis (QUOY & GAIMARD, 1824).

Environ Toxicol Pharmacol 2019 Feb 19;66:75-82. Epub 2018 Dec 19.

Laboratório de Ictiologia Aplicada, Universidade Vila Velha (UVV), Rua Comissário José Dantas de Melo, 21 - Boa Vista, Vila Velha, ES, 29102-920, Brazil. Electronic address:

Lead is toxic to fish, and its toxicity can be aggravated by the water temperature. Geophagus brasiliensis populations are geographically widespread and thus live in areas with different temperatures. The objective of this work was to evaluate the effects of lead-contaminated feed in fish (Geophagus brasiliensis) exposed to different temperatures. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.013DOI Listing
February 2019
1 Read

Bioconcentration and ecotoxicity of sulfadiazine in the aquatic midge Chironomus riparius.

Environ Toxicol Pharmacol 2019 Feb 31;66:69-74. Epub 2018 Dec 31.

Key Laboratory of Agri-food Safety of Anhui Province, School of Resources and Environment, Anhui Agricultural University, Hefei, 230036, China. Electronic address:

Although sulfadiazine (SDZ) is widespread in aquatic environments, information regarding the effects of SDZ on aquatic insects is still limited. In the present study, the bioconcentration and the effects of SDZ on the antioxidant system and the expression of endocrine and stress-related genes in Chironomus riparius larvae were investigated. The larvae were exposed to SDZ at the nominal concentrations of 2, 20 and 200 μg/L for 48 h. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.021DOI Listing
February 2019

Evaluating the protective efficacy of Silybum marianum against deltamethrin induced hepatotoxicity in piscine model.

Environ Toxicol Pharmacol 2019 Feb 21;66:62-68. Epub 2018 Dec 21.

Aquatic Biology Laboratory, Department of Zoology, Panjab University, Chandigarh, India.

With the known facts of deltamethrin toxicity in aquaculture, efforts have been made to ameliorate its toxicity with supplementation of Silybum marianum plant extract in Cyprinus carpio. For validating its efficacy, standard techniques of histopathology, anti-oxidant profile and RAPD-PCR were used. By performing acute toxicity bioassay, 96 h LC of the pesticide to C. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183021
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http://dx.doi.org/10.1016/j.etap.2018.12.014DOI Listing
February 2019
4 Reads

Haemato-immunological studies in ZnO and TiO nanoparticles exposed euryhaline fish, Oreochromis mossambicus.

Environ Toxicol Pharmacol 2019 Feb 19;66:55-61. Epub 2018 Dec 19.

Analytical Spectroscopy Section, Analytical Chemistry Division, Bhabha Atomic Research Center, Trombay, Mumbai 400085, India.

The present study was aimed to analyze the effect of ZnO and TiO nanoparticles (NPs) on Haemato-immunological parameters in adult Tilapia, Oreochromis mossambicus. The nanoparticles size found as 47 nm and 30 nm for ZnO and TiO respectively. The acute toxicity (96 h) of ZnO (LC50: 100-110 ppm) and TiO (LC50: 80-90 ppm) NPs were identified by using probit analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183057
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http://dx.doi.org/10.1016/j.etap.2018.12.011DOI Listing
February 2019
1 Read

Comparison of the effects of sulforaphane and pioglitazone on insulin resistance and associated dyslipidemia, hepatosteatosis, and endothelial dysfunction in fructose-fed rats.

Environ Toxicol Pharmacol 2019 Feb 13;66:43-54. Epub 2018 Dec 13.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

The purpose of this work was to compare the influences of sulforaphane (SFN) to those of the standard insulin sensitizer pioglitazone (PIO) on high fructose diet (HFrD)-induced insulin resistance, dyslipidemia, hepatosteatosis, and vascular dysfunction in rats. Male Sprague Dawley rats (150-200 g) were fed on a standard diet (control) or a high fructose diet (HFrD, 60% w/w fructose) for 60 days. From day 16, two subgroups of HFrD-fed rats received either SFN (0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183057
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http://dx.doi.org/10.1016/j.etap.2018.12.008DOI Listing
February 2019
6 Reads

Acute exposure to a glyphosate-containing herbicide formulation inhibits Complex II and increases hydrogen peroxide in the model organism Caenorhabditis elegans.

Environ Toxicol Pharmacol 2019 Feb 24;66:36-42. Epub 2018 Dec 24.

Northeast Ohio Medical University Department of Pharmaceutical Sciences, 4209 State Route 44, PO Box 95 Rootstown, OH 44272, USA. Electronic address:

Glyphosate-based herbicides, such as Touchdown (TD) and Roundup, are among the most heavily-used herbicides in the world. While the active ingredient is generally considered non-toxic, the toxicity resulting from exposure to commercially-sold formulations is less clear. In many cases, cell cultures or various model organisms exposed to glyphosate formulations show toxicity and, in some cases, lethality. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360103PMC
February 2019

Organochlorine pesticides and polychlorinated biphenyls (PCBs) in early adulthood and blood lipids over a 23-year follow-up.

Environ Toxicol Pharmacol 2019 Feb 23;66:24-35. Epub 2018 Dec 23.

Department of Preventive Medicine, School of Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Daegu, 700-422, Republic of Korea. Electronic address:

Background: Some evidence in humans suggests that persistent organic pollutants (POPs), including organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), may alter the blood lipid composition. This study analyzed associations between serum POPs concentrations in young adulthood with blood lipid levels up to 23 years later.

Methods: Serum POPs were measured in year 2 of follow-up (n = 180 men and women, ages: 20-32y), and plasma lipids in follow-up years 2, 7, 10, 15, 20 and 25. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.018DOI Listing
February 2019

DNA damage checkpoint response to aflatoxin B1.

Environ Toxicol Pharmacol 2019 Jan 7;65:90-96. Epub 2018 Dec 7.

Gazi University, Faculty of Medicine, Department of General Surgery, Ankara, Turkey.

Although most countries regulate the aflatoxin levels in food by legislations, high amounts of aflatoxin B1 (AFB1)-DNA adducts can still be detected in normal and tumorous tissue obtained from cancer patients. AFB1 cannot directly interact with DNA unless it is biotransformed to AFB1-8, 9-epoxide via cytochrome p450 enzymes. This metabolite spontaneously and irreversibly attaches to guanine residues to generate highly mutagenic DNA adducts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183029
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http://dx.doi.org/10.1016/j.etap.2018.12.006DOI Listing
January 2019
6 Reads

Sodium arsenite exposure impairs B cell proliferation and enhances vascular inflammation in Plasmodium berghei mouse model.

Environ Toxicol Pharmacol 2019 Feb 16;66:7-13. Epub 2018 Dec 16.

Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok 10210, Thailand; Center of Excellence on Environmental Health and Toxicology (EHT), Office of Higher Education Commission, Ministry of Education, Bangkok 10400, Thailand. Electronic address:

Arsenic exposure has been linked to an impaired immune response and inflammation. Our study investigated the effects of sodium arsenite on host immune response and vascular inflammation during malarial infection. Mice were divided into three groups: control (C), Plasmodium berghei infection (I) and sodium arsenite exposure with Plasmodium berghei infection (As-I). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183057
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http://dx.doi.org/10.1016/j.etap.2018.12.010DOI Listing
February 2019
4 Reads

Latent role of in vitro Pb exposure in blocking Aβ clearance and triggering epigenetic modifications.

Environ Toxicol Pharmacol 2019 Feb 19;66:14-23. Epub 2018 Dec 19.

College of Public Health, Zhengzhou University, Zhengzhou, PR China. Electronic address:

Both β-amyloid (Aβ) catabolism and epigenetic regulation play critical roles in the onset of neurodegeneration. The latter also contribute to Pb neurotoxicity. The present study explored the role of epigenetic modifiers and Aβ degradation enzymes in Pb-induced latent effects on Aβ overproduction in vitro. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.015DOI Listing
February 2019
1 Read

Effects of deltamethrin on the antioxidant defense and heat shock protein expression in Chinese mitten crab, Eriocheir sinensis.

Environ Toxicol Pharmacol 2019 Feb 19;66:1-6. Epub 2018 Dec 19.

Key Laboratory of Animal Disease Detection and Prevention in Panxi District, Xichang University, Xichang, 415000, China. Electronic address:

In the present study, the status of antioxidant response and molecular regulation in Chinese mitten crab, Eriocheir sinensis under the exposure of synthetic pyrethroid deltamethrin were investigated by means of measuring the antioxidative enzyme activity and relative mRNA expression of heat shock proteins (HSPs) in hepatopancreas. The results showed that activity of superoxide dismutase (SOD) and catalase (CAT) decreased remarkably in all treatments except the SOD activity at concentration of 0.073 μg/L. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.012DOI Listing
February 2019

Manuscript prepared for submission to environmental toxicology and pharmacology pollution in drinking water source areas: Microplastics in the Danjiangkou Reservoir, China.

Environ Toxicol Pharmacol 2019 Jan 17;65:82-89. Epub 2018 Dec 17.

Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; Sino-Africa Joint Research Center, Chinese Academy of Sciences, Wuhan, 430074, China. Electronic address:

As the source of water for the South-to-North Water Diversion Project of China, the water quality of the Danjiangkou Reservoir (DJKR) is related to the safety of drinking water for billions of residents. Consequently, microplastics in surface water and sediment samples of the DJKR were investigated in this study. Microplastics were observed in all water and sediment samples with abundances varying from 467 to 15,017 n/m and 15 to 40 n/kg wet weight, respectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183031
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http://dx.doi.org/10.1016/j.etap.2018.12.009DOI Listing
January 2019
1 Read

Senkyunolide H protects against MPP-induced apoptosis via the ROS-mediated mitogen-activated protein kinase pathway in PC12 cells.

Environ Toxicol Pharmacol 2019 Jan 13;65:73-81. Epub 2018 Dec 13.

Tianjin Key Laboratory of Pulp & Paper, Tianjin University of Science & Technology, Tianjin, 300457, China; Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental protection/Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, Huaiyin Normal University, Huaian, 223300, China. Electronic address:

Senkyunolide H (SNH) is a phthalide isolated from the rhizome of Ligusticum chuanxiong Hort. that has been reported to have several pharmacological activities, including anti-atherosclerotic, antiproliferative, and cytoprotective effects. In this study, we investigated the neuroprotective effects and potential mechanisms of SNH against 1-methyl-4-phenylpyridinium (MPP)-induced oxidative stress. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183057
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http://dx.doi.org/10.1016/j.etap.2018.12.007DOI Listing
January 2019
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Differential biological effects in two pedigrees of clam Ruditapes philippinarum exposed to cadmium using iTRAQ-based proteomics.

Environ Toxicol Pharmacol 2019 Jan 4;65:66-72. Epub 2018 Dec 4.

Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, 264003, PR China; Function Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China.

Due to the industrial discharges, cadmium (Cd) has been one of typical heavy metal pollutants in the Bohai Sea. Manila clam Ruditapes philippinarum is frequently used for pollution biomonitoring and consists of several pedigrees, of which White and Zebra clams are the dominant pedigrees along the Bohai Sea coast. However, limited attention has been paid on the differential biological effects in different pedigrees of clam to heavy metals. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.002DOI Listing
January 2019

Hepatoprotective benefits of vitamin C against perfluorooctane sulfonate-induced liver damage in mice through suppressing inflammatory reaction and ER stress.

Environ Toxicol Pharmacol 2019 Jan 5;65:60-65. Epub 2018 Dec 5.

College of Pharmacy, Guangxi Medical University, Guangxi, Nanning, 530021, PR China. Electronic address:

Our previous studies show that vitamin C (VC) plays promising hepatoprotection in mice. Intrahepatic exposure of perfluorooctane sulfonate (PFOS) can induce dose-dependent cytotoxicity. However, pharmacology-based assessment of VC on PFOS remains uninvestigated. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.004DOI Listing
January 2019
7 Reads

Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes.

Environ Toxicol Pharmacol 2019 Jan 3;65:53-59. Epub 2018 Dec 3.

Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand; Translational Medicine Graduate Program, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

Cadmium is a highly neurotoxic heavy metal impairing neurogenesis and induces neurodegenerative disorders. Toxic concentrations of cadmium induce astrocytic apoptosis by depleting intracellular glutathione levels, elevating intracellular calcium levels, altering mitochondria membrane potentials, and activating JNK and PI3K/Akt signaling pathways. Cadmium suppresses cell proliferation in kidney epithelial cells, lung fibroblasts, and primary myelocytes; however, cadmium's effects on proteins regulating oxidative stress, apoptosis, and cell proliferation in astrocytes are less known. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.001DOI Listing
January 2019
3 Reads

Effects of ammonia nitrogen on gill mitochondria in clam Ruditapes philippinarum.

Environ Toxicol Pharmacol 2019 Jan 3;65:46-52. Epub 2018 Dec 3.

Biology School of Yantai University, Yantai 264005, PR China.

Ammonia nitrogen exposure has been found to significantly increase the early apoptosis rates of gill cells, affect the contents of ATP and disturb expressions of calcium-related genes in clam Ruditapes philippinarum. Mitochondria are the centers for energy production, initiation of apoptosis and calcium signal regulation. It is hypothesized that gill mitochondrion is a target organelle for the ammonia nitrogen. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.003DOI Listing
January 2019

Pharmacokinetics and brain distribution of amitraz and its metabolites in rats.

Environ Toxicol Pharmacol 2019 Jan 23;65:40-45. Epub 2018 Nov 23.

Zoetis, Inc., Veterinary Medicine Research and Development, Kalamazoo, MI, 49007, USA.

Amitraz is an acaricide and insecticide widely used in agriculture and veterinary medicine. Although central nervous system (CNS) toxicity is one of major toxicities following oral ingestion of amitraz, the understanding of the cause of the toxicity is limited. This study evaluated the systemic and brain exposure of amitraz and its major metabolites, BTS27271, 2',4'-formoxylidide, and 2,4-dimethylaniline following administration of amitraz in male Sprague-Dawley rats. Read More

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http://dx.doi.org/10.1016/j.etap.2018.11.005DOI Listing
January 2019
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Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: Contribution to mode of action research.

Environ Toxicol Pharmacol 2019 Jan 23;65:31-39. Epub 2018 Nov 23.

Laboratory for Ecotoxicology - LECOTOX, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg D. Obradovica 2, 21000, Novi Sad, Serbia.

Physiological responses of bacterial, fish, rat and human hepatoma cells to the technical cypermethrin (AS), cypermethrin-based plant protection product (PPP), and the major co-formulant (solvent) were compared. The endpoints included: bioluminescence, total protein content, activity of mitochondrial dehydrogenase and cytochrome P450 (CYP) enzymes CYP1A and CYP1B, and expression of several genes encoding different CYP enzyme isoforms. Toxicity of PPP was compared with the toxicity predicted using concentration addition model. Read More

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http://dx.doi.org/10.1016/j.etap.2018.11.007DOI Listing
January 2019
5 Reads

Carbon nanotubes and central nervous system: Environmental risks, toxicological aspects and future perspectives.

Environ Toxicol Pharmacol 2019 Jan 22;65:23-30. Epub 2018 Nov 22.

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy. Electronic address:

Due to their morphological and physicochemical properties, carbon nanotubes (CNTs) enhance the structural properties of several materials and are produced in great volumes. The production and the manufacturing of CNTs-incorporated products can lead to the potential environmental release of CNTs. For these reasons, CNTs can represent a serious concern for human health. Read More

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http://dx.doi.org/10.1016/j.etap.2018.11.006DOI Listing
January 2019
2 Reads

Iranian experiences in terms of consumption of disposable single- use plastics: Introduction to theoretical variables for developing environmental health promotion efforts.

Environ Toxicol Pharmacol 2019 Jan 14;65:18-22. Epub 2018 Nov 14.

Health Promotion Research Center, Iran University of Medical Sciences, Tehran, Iran.

In recent years, the consumption of disposable plastic items such as single-use plastic bags, plates, cutlery and so on has rapidly increased in Iran. Present study explored the Iranians' experiences in terms of the consumption of disposable single-use plastics. A qualitative content analysis study was conducted in Delfan, Lorestan, Iran in 2017. Read More

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http://dx.doi.org/10.1016/j.etap.2018.11.004DOI Listing
January 2019

Glutathione S-transferase M1 and T1 null allele frequencies among Indonesian ethnics toward improved disease risk assessment.

Environ Toxicol Pharmacol 2019 Jan 2;65:14-17. Epub 2018 Nov 2.

Genetic/Genomic Research Center, YARSI Research Institute, Universitas YARSI, Cempaka Putih, Jakarta Pusat, DKI Jakarta, Indonesia; Department of Pharmacology, Faculty of Medicine, Universitas YARSI, Cempaka Putih, Jakarta Pusat, DKI Jakarta, Indonesia; The Indonesian Pharmacogenomics Working Group, DKI Jakarta, Indonesia. Electronic address:

Genetic variations in the glutathione S-transferase genes GSTT1 and GSTM1 have been widely studied, and homozygous deletions or null genotypes have been reported in different populations. Previous studies suggest that individuals who are homozygous-null at the GSTM1 or GSTT1 locus may have an increased risk of environmentally related cancers and drug-induced hepatotoxicity. The aim of the present study was to determine the GSTM1 and GSTT1 polymorphisms in 154 healthy, unrelated individuals from the Javanese-Sundanese and Malay ethnic populations of Indonesia to provide a resource for improving the prognosis of possible susceptibilities in specific populations. Read More

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http://dx.doi.org/10.1016/j.etap.2018.10.008DOI Listing
January 2019
8 Reads

Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective.

Environ Toxicol Pharmacol 2019 Jan 28;65:9-13. Epub 2018 Oct 28.

Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece. Electronic address:

The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. Read More

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http://dx.doi.org/10.1016/j.etap.2018.10.005DOI Listing
January 2019
9 Reads

Thymol exposure mediates pro-oxidant shift by regulating Nrf2 and apoptotic events in zebrafish (Danio rerio) embryos.

Environ Toxicol Pharmacol 2019 Jan 7;65:1-8. Epub 2018 Nov 7.

Department of Biotechnology, College of Engineering, Daegu University Kyoungsan, Kyoungbook 712-714, Republic of Korea. Electronic address:

The biochemical process of oxidative stress is an integral mechanism of chemical toxicity, contributing to complex pathological disorders. Thymol (THY) has a wide range of therapeutic applications for several ailments, although a better understanding of signaling cues regulated by this compound is needed to address the mechanism of its action. To better perceive the mode of action, we investigated the potential impact of THY on zebrafish embryos, with special emphasis on ROS biogenesis. Read More

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http://dx.doi.org/10.1016/j.etap.2018.11.001DOI Listing
January 2019
5 Reads

In vitro toxicological activity of particulate matter generated by coal combustion.

Environ Toxicol Pharmacol 2018 Dec 8;64:187-195. Epub 2018 Nov 8.

College of Agriculture, Life & Environment Sciences, Chungbuk National University, Cheongju 362-763, Republic of Korea. Electronic address:

Herein, the toxicity of particles generated from the complete combustion of 1 g coal at 500, 700, and 900 °C were compared, and combustion at 700 °C generated the most toxins. Chemical analyses revealed that all components except catechol, resorcinol, and aromatic amines were most abundant at 700 °C. Toxicity results confirmed that the relative mutagenicity, cytotoxicity, redox cycling, and production of reactive oxygen species was highest for particles generated at 700 °C. Read More

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http://dx.doi.org/10.1016/j.etap.2018.11.003DOI Listing
December 2018
4 Reads

Could the environmental toxicity of diclofenac in vultures been predictable if preclinical testing methodology were applied?

Environ Toxicol Pharmacol 2018 Dec 26;64:181-186. Epub 2018 Oct 26.

Veterinary Pharmacology/Toxicology, Department of Paraclinical Sciences, University of Pretoria, Onderstepoort, South Africa; University of Pretoria Biotechnology Research Centre, South Africa. Electronic address:

Diclofenac, a non-steroidal anti-inflammatory pharmaceutical agent was responsible for the death of millions of Gyps vulture's in the Indian sub-region with the safety of the other non-steroidal anti-inflammatory drugs (NSAIDs) being questionable. With preclinical safety testing not well established for avian species unlike for mammalian and environmental toxicity, we ask the question if a preclinical model could have predicted the toxic effect of the drug. For this study, we test an Organisation for Economic Co-operation and Development (OECD) guideline 223 for assessing the acute toxic potential of pesticides in birds by exposing three avian species to the drug. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183054
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http://dx.doi.org/10.1016/j.etap.2018.10.006DOI Listing
December 2018
9 Reads

Toxic effects and possible mechanisms following malathion exposure in porcine granulosa cells.

Environ Toxicol Pharmacol 2018 Dec 6;64:172-180. Epub 2018 Nov 6.

College of Life Sciences, Institute of Reproductive Sciences, Qingdao Agricultural University, Qingdao, 266109, China. Electronic address:

Malathion is a wide spectrum organophosphorothionate insecticide that is frequently found in drinking water, food and foodstuffs. Ovarian granulosa cells modulate oogenesis by providing metabolic nutrients to oocytes. They can decide the fate of folliculogenesis and oocyte maturation by supplying regulatory cues that help in reproduction. Read More

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http://dx.doi.org/10.1016/j.etap.2018.11.002DOI Listing
December 2018
8 Reads

Microplastic in marine organism: Environmental and toxicological effects.

Environ Toxicol Pharmacol 2018 Dec 2;64:164-171. Epub 2018 Nov 2.

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres, 31, 98166 Messina, Italy. Electronic address:

Microplastics are tiny ubiquitous plastic particles present in marine environments. They are not an individual entity, but constitute a cocktail of polymers and additives that can absorb substances from the surrounding environment, including living substances, nutrients and marine pollutants. Given their small size (< 5 μm), microplastics can be ingested by a wide range of marine organisms with the potential to cause harms. Read More

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http://dx.doi.org/10.1016/j.etap.2018.10.009DOI Listing
December 2018
29 Reads

Protective role of l-glutamic acid and l-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats.

Environ Toxicol Pharmacol 2018 Dec 2;64:155-163. Epub 2018 Nov 2.

Institute of Animal Biology, Lviv 79034, Ukraine.

Exposure to the organophosphorus insecticide chlorpyrifos (CPF) can lead to oxidative stress. The aim of this work was to investigate and compare the protective effects of amino acids (l-glutamic acid (l-Glu) and l-cysteine (L-Cys) alone or in combination) for the purpose of suppression and mitigation of CPF-induced oxidative stress in rats. Rats were divided into five groups: CPF, CPF/L-Glu, CPF/L-Glu and l-Cys, CPF/L-Cys, control. Read More

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http://dx.doi.org/10.1016/j.etap.2018.10.010DOI Listing
December 2018
8 Reads

Assessment of exogenous melatonin action on mouse liver cells after exposure to soman.

Environ Toxicol Pharmacol 2018 Dec 29;64:147-154. Epub 2018 Oct 29.

Department of Pharmacology and Toxicology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.

Melatonin is a hormone with many different biological activities and therefore seems to be an important factor reducing the harmful effects caused by toxic organophosphorus compounds. In this study, we attempted to evaluate the protective effect of melatonin on liver cells of mice challenged with chemical warfare agent-soman. The study was conducted at the level of ultrastructural and biochemical changes (analysis of the activity of model lysosomal enzymes and assessment of the level of lipid peroxidation). Read More

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http://dx.doi.org/10.1016/j.etap.2018.10.007DOI Listing
December 2018
8 Reads