13,839 results match your criteria Environmental Health Perspectives [Journal]


Exposure to Residential Greenness as a Predictor of Cause-Specific Mortality and Stroke Incidence in the Rome Longitudinal Study.

Environ Health Perspect 2019 Feb;127(2):27002

1 Department of Epidemiology-Regional Health Service, ASL Roma 1 , Rome, Italy.

Background: Living in areas with higher levels of surrounding greenness and access to urban green areas have been associated with beneficial health outcomes. Some studies suggested a beneficial influence on mortality, but the evidence is still controversial.

Objectives: We used longitudinal data from a large cohort to estimate associations of two measures of residential greenness exposure with cause-specific mortality and stroke incidence. Read More

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http://dx.doi.org/10.1289/EHP2854DOI Listing
February 2019

Guiding Communities Affected by PFASs: Tools for Tackling Contaminated Drinking Water.

Authors:
Nate Seltenrich

Environ Health Perspect 2019 Feb;127(2):24003

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http://dx.doi.org/10.1289/EHP4170DOI Listing
February 2019

Air Pollution and Risk of Neurobehavioral Problems: Is [Formula: see text] Status a Factor?

Authors:
Julia R Barrett

Environ Health Perspect 2019 Feb;127(2):24002

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http://dx.doi.org/10.1289/EHP4810DOI Listing
February 2019

Radon Risk: A Global Estimate of Radon's Contribution to Lung Cancer.

Authors:
Nate Seltenrich

Environ Health Perspect 2019 Feb;127(2):24001

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http://dx.doi.org/10.1289/EHP4169DOI Listing
February 2019

Greenness and Depression Incidence among Older Women.

Environ Health Perspect 2019 Feb;127(2):27001

1 Department of Environmental Health, Harvard T.H. Chan School of Public Health , Boston, Massachusetts, USA.

Background: Recent evidence suggests that higher levels of residential greenness may contribute to better mental health. Despite this, few studies have considered its impact on depression, and most are cross-sectional.

Objective: The objective of this study was to examine surrounding residential greenness and depression risk prospectively in the Nurses' Health Study. Read More

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http://dx.doi.org/10.1289/EHP1229DOI Listing
February 2019

Statistical Methodology in Studies of Prenatal Exposure to Mixtures of Endocrine-Disrupting Chemicals: A Review of Existing Approaches and New Alternatives.

Environ Health Perspect 2019 Feb;127(2):26001

1 School of Public Health, Faculty of Medicine, The University of Queensland , Brisbane, Queensland, Australia.

Background: Prenatal exposures to endocrine-disrupting chemicals (EDCs) during critical developmental windows have been implicated in the etiologies of a wide array of adverse perinatal and pediatric outcomes. Epidemiological studies have concentrated on the health effects of individual chemicals, despite the understanding that EDCs act together via common mechanisms, that pregnant women are exposed to multiple EDCs simultaneously, and that substantial toxicological evidence of adverse developmental effects has been documented. There is a move toward multipollutant models in environmental epidemiology; however, there is no current consensus on appropriate statistical methods. Read More

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http://dx.doi.org/10.1289/EHP2207DOI Listing
February 2019
2 Reads

Associations between Coarse Particulate Matter Air Pollution and Cause-Specific Mortality: A Nationwide Analysis in 272 Chinese Cities.

Environ Health Perspect 2019 Jan;127(1):17008

3 National Center for Chronic Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, China.

Background: Coarse particulate matter with aerodynamic diameter between 2.5 and [Formula: see text] ([Formula: see text]) air pollution is a severe environmental problem in developing countries, but its challenges to public health were rarely evaluated.

Objective: We aimed to investigate the associations between day-to-day changes in [Formula: see text] and cause-specific mortality in China. Read More

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http://dx.doi.org/10.1289/EHP2711DOI Listing
January 2019
1 Read

Organophosphate Pesticide Metabolite Concentrations in Urine during Pregnancy and Offspring Nonverbal IQ at Age 6 Years.

Environ Health Perspect 2019 01;127(1):17007

Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services, Durham, North Carolina, USA.

Background: Susceptibility to organophosphate (OP) pesticide neurotoxicity may be greatest during the prenatal period; however, previous studies have produced mixed findings concerning OP pesticide exposure and child cognition.

Objectives: Our objective was to determine whether maternal urinary concentrations of OP pesticide metabolites are inversely associated with child nonverbal IQ at 6 y of age and to examine potential effect measure modification by the gene.

Methods: Data came from 708 mother–child pairs participating in the Generation R Study. Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3024
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http://dx.doi.org/10.1289/EHP3024DOI Listing
January 2019
3 Reads

Associations of Fetal Growth Outcomes with Measures of the Combined Xenoestrogenic Activity of Maternal Serum Perfluorinated Alkyl Acids in Danish Pregnant Women.

Environ Health Perspect 2019 01;127(1):17006

Centre for Arctic Health and Molecular Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.

Background: Higher concentrations of single perfluorinated alkyl acids (PFAAs) have been associated with lower birth weight (BW), but few studies have examined the combined effects of PFAA mixtures. PFAAs have been reported to induce estrogen receptor (ER) transactivity, and estrogens may influence human fetal growth. We hypothesize that mixtures of PFAAs may affect human fetal growth by disrupting the ER. Read More

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http://dx.doi.org/10.1289/EHP1884DOI Listing
January 2019

Face Mask Use and Persistence of Livestock-associated Nasal Carriage among Industrial Hog Operation Workers and Household Contacts, USA.

Environ Health Perspect 2018 12;126(12):127005

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Background: Industrial hog operation (IHO) workers may persistently carry antibiotic-resistant, livestock-associated in their nasal cavities. It is unclear whether IHO work activities can alter IHO workers' and their household members' exposure to these bacteria.

Objective: Our objective was to investigate the relationship of IHO work activities with persistence of antibiotic-resistant, livestock-associated S. Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3453
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http://dx.doi.org/10.1289/EHP3453DOI Listing
December 2018
4 Reads

Use of a Mouse Model of Experimentally Induced Endometriosis to Evaluate and Compare the Effects of Bisphenol A and Bisphenol AF Exposure.

Environ Health Perspect 2018 12;126(12):127004

Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Background: Endometriosis is a gynecological disease affecting 1 in 10 women of reproductive age. Endometriosis incidence has risen; however, whether this rise is due to disease awareness or environmental contamination is not known.

Objective: The objective of this study was to determine if bisphenol A (BPA) or bisphenol AF (BPAF) potentiate the development of endometriosis and if hormonal status alters how toxicant exposure affects disease. Read More

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http://dx.doi.org/10.1289/EHP3802DOI Listing
December 2018

Native American Perspectives on Health and Traditional Ecological Knowledge.

Environ Health Perspect 2018 12;126(12):125002

Natural Resources Institute, University of Manitoba, Manitoba, Canada.

Background: Traditional ecological knowledge (TEK) is a conceptual framework that highlights Indigenous knowledge (IK) systems. Although scientific literature has noted the relevance of TEK for environmental research since the 1980s, little attention has been given to how Native American (NA) scholars engage with it to shape tribal-based research on health, nor how non-Native scholars can coordinate their approaches with TEK. This coordination is of particular importance for environmental health sciences (EHS) research exploring interdisciplinary approaches and the integration of environmental and human health. Read More

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http://dx.doi.org/10.1289/EHP1944DOI Listing
December 2018
7 Reads

Metabolic Phenotype of Wild-Type and -Knockout C57BL/6J Mice Exposed to Inorganic Arsenic: The Role of Dietary Fat and Folate Intake.

Environ Health Perspect 2018 12;126(12):127003

Curriculum in Toxicology, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Background: Inorganic arsenic (iAs) is a diabetogen. Interindividual differences in iAs metabolism have been linked to susceptibility to diabetes in iAs-exposed populations. Dietary folate intake has been shown to influence iAs metabolism, but to our knowledge its role in iAs-associated diabetes has not been studied. Read More

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http://dx.doi.org/10.1289/EHP3951DOI Listing
December 2018

Critical Windows for Associations between Manganese Exposure during Pregnancy and Size at Birth: A Longitudinal Cohort Study in Wuhan, China.

Environ Health Perspect 2018 12;126(12):127006

Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: Prenatal overexposure to manganese (Mn), an essential micronutrient, is related to impaired fetal growth and development. Fetuses appear to be highly sensitive to Mn during short periods of gestation. However, little is known about the critical windows of susceptibility to Mn for humans. Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3423
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http://dx.doi.org/10.1289/EHP3423DOI Listing
December 2018
6 Reads

Estimating the Effects of PM on Life Expectancy Using Causal Modeling Methods.

Environ Health Perspect 2018 12;126(12):127002

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Background: Many cohort studies have reported associations between PM and the hazard of dying, but few have used formal causal modeling methods, estimated marginal effects, or directly modeled the loss of life expectancy.

Objective: Our goal was to directly estimate the effect of PM on the distribution of life span using causal modeling techniques.

Methods: We derived nonparametric estimates of the distribution of life expectancy as a function of PM using data from 16,965,154 Medicare beneficiaries in the Northeastern and mid-Atlantic region states (129,341,959 person-years of follow-up and 6,334,905 deaths). Read More

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http://dx.doi.org/10.1289/EHP3130DOI Listing
December 2018

Future Wildfires and Flooding: Estimates of Increased Likelihood across the United States.

Authors:
Nate Seltenrich

Environ Health Perspect 2018 Dec;126(12):124001

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http://dx.doi.org/10.1289/EHP3935DOI Listing
December 2018

Exposure to Secondhand Smoke and Arrhythmogenic Cardiac Alternans in a Mouse Model.

Environ Health Perspect 2018 12;126(12):127001

Department of Pharmacology, University of California, Davis, Davis, California, USA.

Background: Epidemiological evidence suggests that a majority of deaths attributed to secondhand smoke (SHS) exposure are cardiovascular related. However, to our knowledge, the impact of SHS on cardiac electrophysiology, [Formula: see text] handling, and arrhythmia risk has not been studied.

Objectives: The purpose of this study was to investigate the impact of an environmentally relevant concentration of SHS on cardiac electrophysiology and indicators of arrhythmia. Read More

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http://dx.doi.org/10.1289/EHP3664DOI Listing
December 2018
4 Reads
7.977 Impact Factor

High Pesticide Exposure Events and Olfactory Impairment among U.S. Farmers.

Environ Health Perspect 2019 01;127(1):17005

Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.

Background: Olfactory impairment (OI) is common among older adults and independently predicts all-cause mortality and the risk of several major neurodegenerative diseases. Pesticide exposure may impair olfaction, but empirical evidence is lacking.

Objective: We aimed to examine high pesticide exposure events (HPEEs) in relation to self-reported OI in participants in the Agricultural Health Study (AHS). Read More

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http://dx.doi.org/10.1289/EHP3713DOI Listing
January 2019
2 Reads

A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing.

Environ Health Perspect 2019 01;127(1):14501

National Center for Computational Toxicology, Office of Research and Development (ORD), U.S. Environmental Protection Agency (EPA), Research Triangle Park, North Carolina, USA.

Per- and polyfluoroalkyl substances (PFASs) are a group of fluorinated substances of interest to researchers, regulators, and the public due to their widespread presence in the environment. A few PFASs have comparatively extensive amounts of human epidemiological, exposure, and experimental animal toxicity data (e.g. Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP4555
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http://dx.doi.org/10.1289/EHP4555DOI Listing
January 2019
9 Reads
7.977 Impact Factor

Exposure to Perfluoroalkyl Substances during Fetal Life and Pubertal Development in Boys and Girls from the Danish National Birth Cohort.

Environ Health Perspect 2019 01;127(1):17004

Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.

Background: It remains unsettled whether prenatal exposure to perfluoroalkyl substances (PFASs) affects human reproductive health through potential endocrine disruption.

Objectives: We aimed to explore the associations between prenatal exposure to several PFASs and various aspects of pubertal development in boys and girls.

Methods: We studied two samples ([Formula: see text] and 445) from the Puberty Cohort, nested within the Danish National Birth Cohort (DNBC), measuring PFAS in maternal plasma from early gestation. Read More

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http://dx.doi.org/10.1289/EHP3567DOI Listing
January 2019
2 Reads

Longitudinal, Seasonal, and Occupational Trends of Multiple Pesticides in House Dust.

Environ Health Perspect 2019 01;127(1):17003

Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, Washington, USA.

Background: Children are especially vulnerable to pesticide exposure and can suffer lasting health effects. Because children of farmworkers are exposed to a variety of pesticides throughout development, it is important to explore temporal patterns of coexposures.

Objectives: The objectives of this study were to characterize the pesticide co-exposures, determine how they change over time, and assess differences between farmworker and nonfarmworker households. Read More

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http://dx.doi.org/10.1289/EHP3644DOI Listing
January 2019
1 Read

Prenatal Exposure to Select Phthalates and Phenols and Associations with Fetal and Placental Weight among Male Births in the EDEN Cohort (France).

Environ Health Perspect 2019 01;127(1):17002

Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences (IAB), Inserm U1209, Centre national de la recherche scientifique (CNRS) Unité de recherche (UMR) 5309, Université Grenoble Alpes, Grenoble, France.

Background: The placenta performs crucial physiological functions to ensure normal fetal development. Few epidemiological studies investigated placental weight sensitivity to phthalates and phenols.

Objective: Our goal was to explore whether maternal exposure to select phthalates and phenols is associated with changes in placental weight at birth and in placental–to–birth weight ratio (PFR). Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3523
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http://dx.doi.org/10.1289/EHP3523DOI Listing
January 2019
5 Reads

Geographic, Demographic, and Temporal Variations in the Association between Heat Exposure and Hospitalization in Brazil: A Nationwide Study between 2000 and 2015.

Environ Health Perspect 2019 01;127(1):17001

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Background: Limited evidence is available regarding the association between heat exposure and morbidity in Brazil and how the effect of heat exposure on health outcomes may change over time.

Objectives: This study sought to quantify the geographic, demographic and temporal variations in the heat–hospitalization association in Brazil from 2000–2015.

Methods: Data on hospitalization and meteorological conditions were collected from 1,814 cities during the 2000–2015 hot seasons. Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3889
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http://dx.doi.org/10.1289/EHP3889DOI Listing
January 2019
4 Reads

A Natural Conclusion: When Teens Rank Green Space "Very Important," They Visit More.

Authors:
Carol Potera

Environ Health Perspect 2018 12;126(12):124002

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http://dx.doi.org/10.1289/EHP3797DOI Listing
December 2018
1 Read

Effects of Indoor and Ambient Black Carbon and [Formula: see text] on Pulmonary Function among Individuals with COPD.

Environ Health Perspect 2018 12;126(12):127008

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: Particulate matter (PM) air pollution has been associated with decreased pulmonary function, but the exposure–response relationship in chronic obstructive pulmonary disease (COPD) patients is uncertain, and most studies have only focused on exposures to ambient pollution.

Objectives: We aimed to assess associations between pulmonary function and indoor and ambient PM [Formula: see text] ([Formula: see text]) and black carbon (BC).

Methods: Between November 2012 and December 2014, 125 patients with COPD (mean age, 73. Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3668
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http://dx.doi.org/10.1289/EHP3668DOI Listing
December 2018
2 Reads

Long-Term Exposure to Ultrafine Particles and Incidence of Cardiovascular and Cerebrovascular Disease in a Prospective Study of a Dutch Cohort.

Environ Health Perspect 2018 12;126(12):127007

Institute for Risk Assessment Sciences (IRAS), division of Environmental Epidemiology (EEPI), Utrecht University, Utrecht, Netherlands.

Background: There is growing evidence that exposure to ultrafine particles (UFP; particles smaller than [Formula: see text]) may play an underexplored role in the etiology of several illnesses, including cardiovascular disease (CVD).

Objectives: We aimed o investigate the relationship between long-term exposure to ambient UFP and incident cardiovascular and cerebrovascular disease (CVA). As a secondary objective, we sought to compare effect estimates for UFP with those derived for other air pollutants, including estimates from two-pollutant models. Read More

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http://dx.doi.org/10.1289/EHP3047DOI Listing
December 2018
1 Read

Best Practices for QSAR Model Reporting: Physical and Chemical Properties, Ecotoxicity, Environmental Fate, Human Health, and Toxicokinetics Endpoints.

Environ Health Perspect 2018 12;126(12):126001

Institute of Chemistry, University of Tartu, Tartu, Estonia.

Background: Quantitative and qualitative structure–activity relationships (QSARs) have been used to understand chemical behavior for almost a century. The main source of QSAR models is the scientific literature, but the open question is how well these models are documented.

Objectives: The main aim of this study was to critically analyze the publication practices of QSARs with regard to transparency, potential reproducibility, and independent verification. Read More

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http://dx.doi.org/10.1289/EHP3264DOI Listing
December 2018
1 Read

Advancements in Life Cycle Human Exposure and Toxicity Characterization.

Environ Health Perspect 2018 12;126(12):125001

School of Public Health, University of California, Berkeley, California, USA.

Background: The Life Cycle Initiative, hosted at the United Nations Environment Programme, selected human toxicity impacts from exposure to chemical substances as an impact category that requires global guidance to overcome current assessment challenges. The initiative leadership established the Human Toxicity Task Force to develop guidance on assessing human exposure and toxicity impacts. Based on input gathered at three workshops addressing the main current scientific challenges and questions, the task force built a roadmap for advancing human toxicity characterization, primarily for use in life cycle impact assessment (LCIA). Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3871
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http://dx.doi.org/10.1289/EHP3871DOI Listing
December 2018
12 Reads

A Prospective Study of Environmental Exposures and Early Biomarkers in Autism Spectrum Disorder: Design, Protocols, and Preliminary Data from the MARBLES Study.

Environ Health Perspect 2018 11;126(11):117004

UC Davis MIND (Medical Investigations of Neurodevelopmental Disorders) Institute, UC Davis, Davis, California, USA.

Background: Until recently, environmental factors in autism spectrum disorder (ASD) were largely ignored. Over the last decade, altered risks from lifestyle, medical, chemical, and other factors have emerged through various study designs: whole population cohorts linked to diagnostic and/or exposure-related databases, large case-control studies, and smaller cohorts of children at elevated risk for ASD.

Objectives: This study aimed to introduce the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) prospective study and its goals, motivate the enhanced-risk cohort design, describe protocols and main exposures of interest, and present initial descriptive results for the study population. Read More

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http://dx.doi.org/10.1289/EHP535DOI Listing
November 2018
11 Reads

The Brain before Birth: Using fMRI to Explore the Secrets of Fetal Neurodevelopment.

Authors:
Lindsey Konkel

Environ Health Perspect 2018 11;126(11):112001

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http://dx.doi.org/10.1289/EHP2268DOI Listing
November 2018
2 Reads

Conditioning on Parity in Studies of Perfluoroalkyl Acids and Time to Pregnancy: An Example from the Danish National Birth Cohort.

Environ Health Perspect 2018 11;126(11):117003

Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.

Background: Previous studies have investigated the associations between perfluoroalkyl acids (PFAAs) in women and time to pregnancy (TTP). Inconsistent results may be explained by differences in conditioning on parity.

Objectives: We used causal directed acyclic graphs to illustrate potential confounding related to previous pregnancies and exposure measurement error due to differences in the interpregnancy interval in pregnancy-based studies that include parous women. Read More

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http://dx.doi.org/10.1289/EHP1493DOI Listing
November 2018
1 Read

A State-of-the-Science Review of Mercury Biomarkers in Human Populations Worldwide between 2000 and 2018.

Environ Health Perspect 2018 10;126(10):106001

Department of Public Health, Environmental and Social Determinants of Health, World Health Organization, Geneva, Switzerland.

Background: The Minamata Convention on Mercury provided a mandate for action against global mercury pollution. However, our knowledge of mercury exposures is limited because there are many regions and subpopulations with little or no data.

Objective: We aimed to increase worldwide understanding of human exposures to mercury by collecting, collating, and analyzing mercury concentrations in biomarker samples reported in the published scientific literature. Read More

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http://dx.doi.org/10.1289/EHP3904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371716PMC
October 2018
1 Read

Signaling Events Downstream of AHR Activation That Contribute to Toxic Responses: The Functional Role of an AHR-Dependent Long Noncoding RNA () Using the Zebrafish Model.

Environ Health Perspect 2018 11;126(11):117002

Department of Environmental and Molecular Toxicology, Sinnhuber Aquatic Research Laboratory, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon, USA.

Background: A structurally diverse group of chemicals, including dioxins [e.g., 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD)] and polycyclic aromatic hydrocarbons (PAHs), can xenobiotically activate the aryl hydrocarbon receptor (AHR) and contribute to adverse health effects in humans and wildlife. Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3281
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http://dx.doi.org/10.1289/EHP3281DOI Listing
November 2018
13 Reads
7.980 Impact Factor

Estimates of the Global Burden of Ambient [Formula: see text], Ozone, and [Formula: see text] on Asthma Incidence and Emergency Room Visits.

Environ Health Perspect 2018 10;126(10):107004

Stockholm Environment Institute, York, UK.

Background: Asthma is the most prevalent chronic respiratory disease worldwide, affecting 358 million people in 2015. Ambient air pollution exacerbates asthma among populations around the world and may also contribute to new-onset asthma.

Objectives: We aimed to estimate the number of asthma emergency room visits and new onset asthma cases globally attributable to fine particulate matter ([Formula: see text]), ozone, and nitrogen dioxide ([Formula: see text]) concentrations. Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3766
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http://dx.doi.org/10.1289/EHP3766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371661PMC
October 2018
11 Reads

Longitudinal Analysis of Long-Term Air Pollution Levels and Blood Pressure: A Cautionary Tale from the Multi-Ethnic Study of Atherosclerosis.

Environ Health Perspect 2018 10;126(10):107003

Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington, USA.

Background: Air pollution exposures are hypothesized to impact blood pressure, yet few longitudinal studies exist, their findings are inconsistent, and different adjustments have been made for potentially distinct confounding by calendar time and age.

Objective: We aimed to investigate the associations of long- and short-term [Formula: see text] and [Formula: see text] concentrations with systolic and diastolic blood pressures and incident hypertension while also accounting for potential confounding by age and time.

Methods: Between 2000 and 2012, Multi-Ethnic Study of Atherosclerosis participants were measured for systolic and diastolic blood pressure at five exams. Read More

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http://dx.doi.org/10.1289/EHP2966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371645PMC
October 2018
6 Reads

Community Water Fluoridation and Urinary Fluoride Concentrations in a National Sample of Pregnant Women in Canada.

Environ Health Perspect 2018 10;126(10):107001

Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.

Background: Fluoride exposures have not been established for pregnant women who live in regions with and without community water fluoridation.

Objective: Our aim was to measure urinary fluoride levels during pregnancy. We also assessed the contribution of drinking-water and tea consumption habits to maternal urinary fluoride (MUF) concentrations and evaluated the impact of various dilution correction standards, including adjustment for urinary creatinine and specific gravity (SG). Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3546
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http://dx.doi.org/10.1289/EHP3546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371693PMC
October 2018
8 Reads

Software Tools to Facilitate Systematic Review Used for Cancer Hazard Identification.

Environ Health Perspect 2018 10;126(10):104501

International Agency for Research on Cancer, World Health Organization, Lyon, France.

Objective and systematic methods to search, review, and synthesize published studies are a fundamental aspect of carcinogen hazard classification. Systematic review is a historical strength of the International Agency for Research on Cancer (IARC) Monographs Program and the United States National Toxicology Program (NTP) Office of the Report on Carcinogens (RoC). Both organizations are tasked with evaluating peer-reviewed, published evidence to determine whether specific substances, exposure scenarios, or mixtures pose a cancer hazard to humans. Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP4224
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http://dx.doi.org/10.1289/EHP4224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371692PMC
October 2018
29 Reads

Long-Term Exposure to Ambient Fine Particulate Matter and Chronic Kidney Disease: A Cohort Study.

Environ Health Perspect 2018 10;126(10):107002

Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, China.

Background: Chronic kidney disease (CKD) is a serious global public health challenge, but there is limited information on the connection between air pollution and risk of CKD.

Objective: The aim of this study was to investigate the association between long-term exposure to particulate matter (PM) with an aerodynamic diameter of less than [Formula: see text] ([Formula: see text]) and the development of CKD in a large cohort.

Methods: A total of 100,629 nonCKD Taiwanese residents age 20 y or above were included in this study between 2001 and 2014. Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3304
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http://dx.doi.org/10.1289/EHP3304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371647PMC
October 2018
19 Reads

Evaluation of Bisphenol A (BPA) Exposures on Prostate Stem Cell Homeostasis and Prostate Cancer Risk in the NCTR-Sprague-Dawley Rat: An NIEHS/FDA CLARITY-BPA Consortium Study.

Environ Health Perspect 2018 11;126(11):117001

Chicago Center for Health and Environment, University of Illinois at Chicago, Chicago, Illinois, USA.

Background: Previous work determined that early life exposure to low-dose Bisphenol A (BPA) increased rat prostate cancer risk with aging. Herein, we report on prostate-specific results from CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on BPA Toxicity), which aims to resolve uncertainties regarding BPA toxicity.

Objectives: We sought to ) reassess whether a range of BPA exposures drives prostate pathology and/or alters prostatic susceptibility to hormonal carcinogenesis, and ) test whether chronic low-dose BPA targets prostate epithelial stem and progenitor cells. Read More

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Source
https://ehp.niehs.nih.gov/doi/10.1289/EHP3953
Publisher Site
http://dx.doi.org/10.1289/EHP3953DOI Listing
November 2018
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