Search our Database of Scientific Publications and Authors

I’m looking for a

    50418 results match your criteria Enteroviral Infections

    1 OF 1009

    Adenovirus type 4 respiratory infections with a concurrent outbreak of coxsackievirus A21 among United States army basic trainees, a retrospective viral etiology study using next-generation sequencing.
    J Med Virol 2017 Feb 15. Epub 2017 Feb 15.
    Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring.
    Background: Human adenoviruses (HAdV), in particular types 4 and 7, frequently cause acute respiratory disease (ARD) during basic military training. HAdV4 and HAdV7 vaccines reduced the ARD risk in US military. It is important to identify other respiratory pathogens and assess their potential impact on military readiness. Read More

    Clinical Course of Enterovirus D68 in Hospitalized Children.
    Pediatr Infect Dis J 2017 Mar;36(3):290-295
    From the *Department of Pediatrics, Children's Mercy Hospital, †Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, and ‡University of Missouri-Kansas City, School of Medicine, Kansas City, Missouri.
    Background: Enterovirus D68 (EV-D68) has been sporadically reported as a cause of respiratory tract infections. In 2014, an international outbreak of EV-D68 occurred and caused severe respiratory disease in the pediatric population.

    Methods: A retrospective chart review was performed of children admitted to Children's Mercy Hospital from August 1, 2014, to September 15, 2014, with positive multiplex polymerase chain reaction testing for EV/rhinovirus (RV). Read More

    Clinical Course of Enterovirus D68 in Hospitalized Children.
    Pediatr Infect Dis J 2016 Dec 13. Epub 2016 Dec 13.
    1Department of Pediatrics, Children's Mercy Hospital, Kansas City, Missouri 2Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, Kansas City, Missouri 3University of Missouri-Kansas City, School of Medicine, Kansas City, Missouri.
    Background: Enterovirus D68 (EV-D68) has been sporadically reported as a cause of respiratory tract infections. In 2014, an international outbreak of EV-D68 occurred and caused severe respiratory disease in the pediatric population.

    Methods: A retrospective chart review was performed of children admitted to Children's Mercy Hospital from August 1-September 15, 2014 with positive multiplex PCR testing for enterovirus/rhinovirus (EV/RV). Read More

    Enterovirus D68 detection in respiratory specimens: Association with severe disease.
    J Med Virol 2017 Feb 6. Epub 2017 Feb 6.
    Univ Lille, Faculté de Médecine, CHU Lille, Laboratoire de Virologie EA3610, F-59000, Lille, France.
    Molecular techniques increased the number of documented respiratory infections. In a substantial number of cases the causative agent remains undetected. Since August 2014, an increase in Enterovirus(EV)-D68 infections was reported. Read More

    In Vivo Persistence of Human Rhinoviruses in Immunosuppressed Patients.
    PLoS One 2017 2;12(2):e0170774. Epub 2017 Feb 2.
    Laboratoire de Virologie EA 3610, Faculté de Médecine, Université Lille et CHU Lille, Lille, France.
    Several species of the genus Enterovirus cause persistent infections in humans. Human rhinovirus (HRV) infections are generally self-limiting but occasionally persistent infections have been described. This study aimed to identify persistent HRV infections and investigate the clinical and virologic characteristics of patients with persistent infections. Read More

    A case of rapid progression of postoperative hyperthermia: Dantrolene or not dilemma?
    Int J Crit Illn Inj Sci 2016 Oct-Dec;6(4):203-205
    Department of Anesthesiology and Pain Medicine, Seattle Children's Hospital, Seattle, WA 98105, USA.
    Malignant hyperthermia (MH) is an extremely rare and life-threatening differential diagnosis of postoperative fever. We present an 8-month-old child scheduled for elective outpatient procedure who rapidly developed high fever, tachycardia, and respiratory acidosis shortly after transfer to the postanesthesia care unit. MH hotline expert recommended administering dantrolene, but there was no evidence of hypermetabolism or lactic acidosis. Read More

    Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner.
    Proc Natl Acad Sci U S A 2017 Feb 30;114(7):1672-1677. Epub 2017 Jan 30.
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219;
    Enteroviruses are among the most common viral infectious agents of humans and are primarily transmitted by the fecal-oral route. However, the events associated with enterovirus infections of the human gastrointestinal tract remain largely unknown. Here, we used stem cell-derived enteroids from human small intestines to study enterovirus infections of the intestinal epithelium. Read More

    Investigation of viral infection in idiopathic pulmonary fibrosis among Iranian patients in Tehran.
    Microb Pathog 2017 Jan 20;104:171-174. Epub 2017 Jan 20.
    Department of Virology, Iran University of Medical Sciences, Tehran, Iran.
    Aim Of The Study: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease, which can be lethal with chronic complications. Viral infections may be associated with IPF and other fibrotic lung diseases. In the present study, we investigate for the first time in Iran the related viral etiology of IPF in order to detect three respiratory viruses; human adenovirus, enterovirus and bocavirus. Read More

    Should Enteroviruses Be Monitored in Natural Recreational Waters?
    Cent Eur J Public Health 2016 Dec;24(4):333-336
    Enterovirus Laboratory, Faculty of Medicine, Slovak Medical University, Bratislava, Slovak Republic.
    Enteroviruses (EVs) infections occur worldwide. Although, infections by these viruses are often asymptomatic and go unnoticed, they can be shed in stool for several weeks. The EVs re associated with sporadic outbreaks and a wide range of clinical symptoms, occasionally accompanied with fatal consequences. Read More

    The Relationships between Respiratory Virus Infection and Aminotransferase in Children.
    Pediatr Gastroenterol Hepatol Nutr 2016 Dec 28;19(4):243-250. Epub 2016 Dec 28.
    Department of Pediatrics, Konyang University College of Medicine, Daejeon, Korea.
    Purpose: We sought to examine the relationship between the clinical manifestations of nonspecific reactive hepatitis and respiratory virus infection in pediatric patients.

    Methods: Patients admitted to the pediatric unit of Konyang University Hospital for lower respiratory tract disease between January 1, 2014 and December 31, 2014 and who underwent reverse transcriptase polymerase chain reaction tests were examined. The patients were divided into those with increased levels of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) and those with normal ALT or AST levels. Read More

    Modulation of Antiviral Immunity by Heme Oxygenase-1.
    Am J Pathol 2017 Mar 9;187(3):487-493. Epub 2017 Jan 9.
    Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile; INSERM, Combined Research Unit 1064, Nantes University Hospital Nantes, Institute for Transplantation-Urology-Nephrology, Université de Nantes, Faculty of Medicine, Nantes, France; Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:
    Heme oxygenase-1 (HO-1) is a stress-inducible, anti-inflammatory, and cytoprotective enzyme expressed in most cell types in the organism. Under several stress stimuli, HO-1 expression and activity is up-regulated to catalyze the rate-limiting enzymatic step of heme degradation into carbon monoxide, free iron, and biliverdin. Besides its effects on cell metabolism, HO-1 is also capable of modulating host innate and adaptive immune responses in response to sepsis, transplantation, and autoimmunity, and preventing oxidative damage associated with inflammation. Read More

    Guidance for Assessment of Poliovirus Vaccination Status and Vaccination of Children Who Have Received Poliovirus Vaccine Outside the United States.
    MMWR Morb Mortal Wkly Rep 2017 Jan 13;66(1):23-25. Epub 2017 Jan 13.
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, CDC.
    In 1988, the World Health Assembly resolved to eradicate poliomyelitis (polio). Since then, wild poliovirus (WPV) cases have declined by >99.9%, from an estimated 350,000 cases of polio each year to 74 cases in two countries in 2015 (1). Read More

    Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.
    Diabetologia 2017 Mar 9;60(3):424-431. Epub 2017 Jan 9.
    Department of Virology, University of Tampere, PL100, 33014, Tampereen yliopisto, Finland.
    Aims/hypothesis: This case-control study was nested in a prospective birth cohort to evaluate whether the presence of enteroviruses in stools was associated with the appearance of islet autoimmunity in the Type 1 Diabetes Prediction and Prevention study in Finland.

    Methods: Altogether, 1673 longitudinal stool samples from 129 case children who turned positive for multiple islet autoantibodies and 3108 stool samples from 282 matched control children were screened for the presence of enterovirus RNA using RT-PCR. Viral genotype was detected by sequencing. Read More

    Epidemiological and clinical features of enteroviral acute lower respiratory tract infections in hospitalized paediatric patients in a Malaysian tertiary center.
    Med J Malaysia 2016 Oct;71(5):264-268
    Hospital Ampang, Paediatrics Department, Selangor, Malaysia.
    Background: Human enteroviruses (HEVs) have been recognized to cause a significant number of respiratory tract infections in many regions. Previous studies conducted to analyse enteroviral respiratory tract infections focused on outbreaks. Data in the Southeast Asian region is still rather limited to date. Read More

    Inhibition of enterovirus 71 replication by an α-hydroxy-nitrile derivative NK-1.9k.
    Antiviral Res 2017 Jan 4. Epub 2017 Jan 4.
    College of Pharmacy & State Key Laboratory of Medicinal Chemical Biology & Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China. Electronic address:
    Enterovirus 71 (EV71) is one of the major etiological agents of human hand-foot-and-mouth disease (HFMD) worldwide. EV71 infection in young children and people with immunodeficiency causes severe symptoms with a high fatality rates. However, there is still no approved drugs to treat such infections. Read More

    Public health response to the silent reintroduction of wild poliovirus to Israel, 2013-2014.
    Clin Microbiol Infect 2016 Dec;22 Suppl 5:S140-S145
    Public Health Services, Ministry of Health, Jerusalem, Israel; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
    During 2013/14, Israel witnessed the silent reintroduction and sustained transmission of wild poliovirus type 1 (WPV1) detected through routine environmental surveillance performed on sewage samples. The public health response to silent poliovirus transmission in a population with high inactivated polio vaccine (IPV) coverage poses an emerging challenge towards the 'End Game' of global poliovirus eradication. This paper reviews the risk assessment, risk management and risk communication aspects of this poliovirus incident. Read More

    Prevalence of rotavirus, adenovirus, hepatitis A virus and enterovirus in water samples collected from different region of Peshawar, Pakistan.
    Ann Agric Environ Med 2016 12;23(4):576-580
    University of Hail, Saudi Arabia.
    Viral gastroenteritis and other water-borne diseases are the most neglected areas of research in Pakistan. To determine the quality of water, 4 enteric viruses were studied from different localities of Peshawar, Pakistan. The study validates the viral detection method for Rotavirus (RV), Human adenovirus (HAdV), Enterovirus (EV) and Hepatitis A virus (HAV), directly from water sources of rural areas of Peshawar, KPK, Pakistan. Read More

    Epidemiologic Analysis of Respiratory Viral Infections Mainly in Hospitalized Children and Adults in a Midwest University Medical Center After the Implementation of a 14-Virus Multiplex Nucleic Acid Amplification Test.
    Am J Clin Pathol 2016 Dec 27. Epub 2016 Dec 27.
    From the Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis.
    Objectives: To investigate the etiology of viral respiratory tract infections mainly in hospitalized children and adults over a 12-month consecutive period after implementation of a 14-virus multiplex nucleic acid amplification test.

    Methods: From January 2014 to January 2015, a total of 2,237 respiratory samples were analyzed with the US Food and Drug Administration-cleared eSensor Respiratory Viral Panel (GenMark Diagnostics, Carlsbad, CA).

    Results: Of the 2,237 specimens tested, 788 specimens were positive for at least one virus, giving a positivity rate of 35. Read More

    An Outbreak of Kingella kingae Infections Complicating a Severe Hand, Foot, And Mouth Disease Outbreak in Nice, France, 2016.
    Pediatr Infect Dis J 2016 Dec 19. Epub 2016 Dec 19.
    1URMITE "Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes", UM63, Inserm 1095, CNRS 7278, IRD 198, Institut Hospitalo-Universitaire Méditerranée-Infection, Aix-Marseille University, Marseille, France. 2Childcare Centers, Nice, France. 3Laboratoire de Virologie, Centre National de Référence des Enterovirus et Parechovirus-laboratoire associé, CHU de Clermont-Ferrand, Clermont-Ferrand, France. 4Department of Pediatric Cardiac Surgery, La Timone Children's Hospital, Aix-Marseille University, Marseille, France. 5Department of Pediatric Emergency Medicine, North Hospital, Marseille, France. 6Department of Pediatrics, Foundation Lenval Children's Hospital, Nice, France. 7Laboratory of Foundation Lenval Children's Hospital, Nice, France. 8IRD French Institute of Research and Development, EHESP French School of Public Health, EPV UMR_D 190 "Emergence des Pathologies Virales", Institut Hospitalo-Universitaire Méditerranée-Infection, Aix Marseille Université, Marseille, France.
    We report the investigative methods for the diagnosis of an epidemic and culture-negative K. kingae endocarditis complicating a severe outbreak of hand, foot, and mouth disease in a childcare center. The diagnosis was confirmed by PCR testings performed from cardiac tissue. Read More

    Intensive Care Admissions for Children With Enterovirus and Human Parechovirus Infections in the United Kingdom and The Republic of Ireland, 2010-2014.
    Pediatr Infect Dis J 2017 Mar;36(3):339-342
    From the *Paediatric Infectious Diseases Research Group, St. George's University of London, and †Public Health England, London, United Kingdom; and ‡Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, United Kingdom.
    Enteroviruses and human parechoviruses usually cause mild, self-limiting illnesses in children but can occasionally cause severe disease. During 2010-2014, 104 children in the United Kingdom and the Republic of Ireland were admitted to a pediatric intensive care unit with severe enterovirus and human parechovirus infection; 40% had neurologic symptoms, 20% respiratory failure, 16% cardiac complications and 11% septic shock. Annual number of cases and incidence increased in the 5-year period, from 0. Read More

    In Vivo Imaging with Bioluminescent Enterovirus 71 Allows for Real-Time Visualization of Tissue Tropism and Viral Spread.
    J Virol 2017 Mar 14;91(5). Epub 2017 Feb 14.
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
    Hand, foot, and mouth disease (HFMD) is a reemerging illness caused by a variety of enteroviruses. The main causative agents are enterovirus 71 (EV71), coxsackievirus A16 (CVA16), and, most recently, coxsackievirus A6 (CVA6). Enterovirus infections can vary from asymptomatic infections to those with a mild fever and blisters on infected individuals' hands, feet, and throats to infections with severe neurological complications. Read More

    Three cases of mumps virus and enterovirus coinfection in children with enteroviral meningitis.
    Medicine (Baltimore) 2016 Dec;95(49):e5610
    aHealth Research Institute, Infectious and Tropical Disease Research Center bVirology Department, Faculty of Medicine cCellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Science, Ahvaz dMicrobilogy Department, Urmia University of Medical Science, Urmia eNarges Genetic Laboratory fAboozar Children's Hospital gFaculty of Medicine hRazi Hospital, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
    Several viruses are responsible for aseptic meningitis; however, in the region of Southwest Iran, the role played by each virus is still not very well known. The aim of this study is to determine the relative frequencies of mumps virus, herpes viruses, and enteroviruses, as well as coinfections among them, in patients with aseptic meningitis.In this cross-sectional study, samples of cerebrospinal fluid were collected between December 2012 and December 2013 from patients under 14 years, who were hospitalized in Abuzar Children's Hospital in Ahvaz, Southwest Iran (the only children's hospital in Khuzestan province and Southwest Iran). Read More

    Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years.
    J Pediatr (Rio J) 2016 Dec 2. Epub 2016 Dec 2.
    Universidade Federal do Paraná (UFPR), Hospital de Clínicas, Divisão de Doenças Infecciosas, Curitiba, PR, Brazil; Universidade Federal do Paraná (UFPR), Hospital de Clínicas, Laboratório de Virologia, Curitiba, PR, Brazil. Electronic address:
    Objectives: To report epidemiological features, clinical characteristics, and outcomes of human rhinovirus (HRV) infections in comparison with other community acquired respiratory virus (CRV) infections in patients hospitalized for two consecutive years.

    Methods: This was a cross-sectional study. Clinical, epidemiological, and laboratory data of patients hospitalized with acute respiratory syndrome in a tertiary care hospital from 2012 to 2013 were reviewed. Read More

    An observational study of febrile seizures: the importance of viral infection and immunization.
    BMC Pediatr 2016 Dec 3;16(1):202. Epub 2016 Dec 3.
    School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia.
    Background: Febrile seizures are common in young children. Annual peaks in incidence mirror increased respiratory virus activity during winter. Limited virological data are available using modern diagnostic techniques for children with febrile seizures. Read More

    Human parechovirus and enterovirus initiate distinct CNS innate immune responses: Pathogenic and diagnostic implications.
    J Clin Virol 2017 Jan 23;86:39-45. Epub 2016 Nov 23.
    Thomas Jefferson University Hospital, Pathology, Philadelphia, PA, United States. Electronic address:
    Background: Human parechovirus (HPeV) and enterovirus (EV) cause a range of human diseases including serious CNS infections. Little is known regarding the immune response to HPeV meningitis compared to EV meningitis or how the immune response to HPeV reflects its pathogenesis.

    Objective: To characterize the innate immune response to HPeV CNS infection in order to increase our understanding of HPeV pathogenesis and possibly help identify HPeV in the clinical setting. Read More

    [Epidemiology, etiology and clinical picture of enteroviral meningitis in children in South Moravia].
    Klin Mikrobiol Infekc Lek 2016 Sep;22(3):100-104
    Depatrment of Children's Infectious Disease, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic, e-mail:
    Objectives: Enteroviruses (EVs) are the most common cause of aseptic viral meningitis. In some cases, they can cause severe meningoencephalitis and acute flaccid paralysis - an association with some virulent serotypes. The objectives were to describe the epidemiological situation of EV meningitis in children in South Moravia, to elucidate the etiology including the incidence of virulent serotypes and to evaluate the clinical presentation. Read More

    A Molecular Approach Applied to Enteroviruses Surveillance in Northern Taiwan, 2008-2012.
    PLoS One 2016 1;11(12):e0167532. Epub 2016 Dec 1.
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes (NHRI), Zhunan Town, Miaoli County, Taiwan.
    Traditional methods for detection and serotyping of enterovirus infections are virus isolation and immunofluorescence assay (VI-IFA), which are labor-intensive and time-consuming. Recently, VP1 gene has been targeted to develop a CODEHOP-based RT-PCR (VP1-CODEHOP) for the same purpose. In this study, we conducted a 5-year enterovirus surveillance comparing the VI-IFA and VP1-CODEHOP tests. Read More

    Genomic characterization of two new enterovirus types, EV-A114 and EV-A121.
    J Med Microbiol 2016 Dec 28;65(12):1465-1471. Epub 2016 Oct 28.
    1​Enterovirus Research Centre, Haffkine Institute Compound, AD Marg, Parel, Mumbai, Maharashtra 400012, India.
    Enteroviruses cause a variety of illnesses of the gastrointestinal tract, central nervous system and cardiovascular system. Phylogenetic analysis of VP1 sequences has identified 106 different human enteroviruses classified into four enterovirus species within the genus Enterovirus of the family Picornaviridae. It is likely that not all enterovirus types have been discovered. Read More

    Motor coordination and balance measurements reveal differential pathogenicity of currently spreading enterovirus 71 strains in human SCARB2 transgenic mice.
    J Gen Virol 2016 Dec 20;97(12):3243-3247. Epub 2016 Oct 20.
    4​Clinical Virology Laboratory, Department of Laboratory Medicine, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan, ROC 2​Graduate Institute of Biomedical Sciences, Chang Gung University, Tao-Yuan, Taiwan, ROC 3​Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan, ROC 1​Research Center for Emerging Viral Infections, Chang Gung University, Tao-Yuan, Taiwan, ROC.
    Enterovirus 71 (EV71) has caused large-scale epidemics with neurological complications in the Asia-Pacific region. The C4a and B5 strains are the two major genotypes circulating in many countries recently. This study used a new protocol, a motor coordination task, to assess the differential pathogenicity of C4a and B5 strains in human SCARB2 transgenic mice. Read More

    Control of the negative IRES trans-acting factor KHSRP by ubiquitination.
    Nucleic Acids Res 2017 Jan 28;45(1):271-287. Epub 2016 Nov 28.
    Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan
    Cells and viruses can utilize internal ribosome entry sites (IRES) to drive translation when cap-dependent translation is inhibited by stress or viral factors. IRES trans-acting factors (ITAFs) are known to participate in such cap-independent translation, but there are gaps in the understanding as to how ITAFs, particularly negative ITAFs, regulate IRES-driven translation. This study found that Lys109, Lys121 and Lys122 represent critical ubiquitination sites for far upstream element-binding protein 2 (KHSRP, also known as KH-type splicing regulatory protein or FBP2), a negative ITAF. Read More

    Comparison analysis of microRNAs in response to EV71 and CA16 infection in human bronchial epithelial cells by high-throughput sequencing to reveal differential infective mechanisms.
    Virus Res 2017 Jan 24;228:90-101. Epub 2016 Nov 24.
    Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, 650118, China. Electronic address:
    Hand, foot, and mouth disease (HFMD) mainly caused by Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) infections which presented significantly different clinical manifestations. Nevertheless, the factors underlying these differences remain unclear. Recently, the functions of microRNAs (miRNAs) in pathogen-host interactions have been highlighted. Read More

    Inhibitory effects of bee venom and its components against viruses in vitro and in vivo.
    J Microbiol 2016 Dec 26;54(12):853-866. Epub 2016 Nov 26.
    College of Veterinary Medicine, Chungnam National University, Daejeon, 34134, Republic of Korea.
    Bee venom (BV) from honey bee (Apis Melifera L.) contains at least 18 pharmacologically active components including melittin (MLT), phospholipase A2 (PLA2), and apamin etc. BV is safe for human treatments dose dependently and proven to possess different healing properties including antibacterial and antiparasitidal properties. Read More

    Progress Toward Poliomyelitis Eradication - Pakistan, January 2015-September 2016.
    MMWR Morb Mortal Wkly Rep 2016 Nov 25;65(46):1295-1299. Epub 2016 Nov 25.
    Pakistan, Afghanistan, and Nigeria remain the only countries where endemic wild poliovirus type 1 (WPV1) transmission continues. This report describes the activities, challenges, and progress toward polio eradication in Pakistan during January 2015-September 2016 and updates previous reports (1,2). In 2015, a total of 54 WPV1 cases were reported in Pakistan, an 82% decrease from 2014. Read More

    Enterovirus A71 and coxsackievirus A16 show different replication kinetics in human neuronal and non-neuronal cell lines.
    Arch Virol 2016 Nov 23. Epub 2016 Nov 23.
    Department of Pathology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
    Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are closely related enteroviruses that cause hand, foot and mouth disease (HFMD) in children. Serious neurological complications almost always occur in EV-A71 infection, but are rare in CV-A16 infection. Based on the hypothesis that this may be because EV-A71 infects neuronal cells more easily than CV-A16, we compared virus infection, replication and spread of EV-A71 and CV-A16 in SK-N-SH cells. Read More

    Enterovirus D68 in Hospitalized Children: Sequence Variation, Viral Loads and Clinical Outcomes.
    PLoS One 2016 22;11(11):e0167111. Epub 2016 Nov 22.
    Department of Pediatrics, Division of Infectious Diseases, Nationwide Children's Hospital, Columbus, Ohio, United States of America.
    Background: An outbreak of enterovirus D68 (EV-D68) caused severe respiratory illness in 2014. The disease spectrum of EV-D68 infections in children with underlying medical conditions other than asthma, the role of EV-D68 loads on clinical illness, and the variation of EV-D68 strains within the same institution over time have not been described. We sought to define the association between EV-D68 loads and sequence variation, and the clinical characteristic in hospitalized children at our institution from 2011 to 2014. Read More

    Clinically isolated enterovirus A71 subgenogroup C4 strain with lethal pathogenicity in 14-day-old mice and the application as an EV-A71 mouse infection model.
    Antiviral Res 2017 Jan 15;137:67-75. Epub 2016 Nov 15.
    Guangdong South China United Vaccine Institute, Guangzhou, China; The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, China. Electronic address:
    The Enterovirus A71 (EV-A71) subgenogroup C4 is prevalent in China. EV-A71 causes hand, foot and mouth disease (HFMD) in children and may lead to severe neurological diseases. The development of antiviral and protective vaccines against EV-A71 is significantly hindered by the lack of suitable animal models to recapitulate human neurological symptoms. Read More

    The extent of using mobility assistive devices can partly explain fatigue among persons with late effects of polio - a retrospective registry study in Sweden.
    BMC Neurol 2016 11 18;16(1):230. Epub 2016 Nov 18.
    Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Background: Fatigue is reported as one of the most disabling symptoms and is common among persons living with late effects of polio. Although fatigue has been studied in the context of people living with late effects of polio, there is a lack of knowledge concerning the association of fatigue and variables of importance for participation in daily life. Therefore, the aim of this study was to explore possible factors associated with fatigue among persons with late effects of polio in Sweden. Read More

    Hepatitis A virus genotype IA-infected patient with marked elevation of aspartate aminotransferase levels.
    Clin J Gastroenterol 2017 Feb 15;10(1):52-56. Epub 2016 Nov 15.
    Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
    We describe a case of acute liver failure (ALF) without hepatic encephalopathy with marked elevation of aminotransferase due to hepatitis A, according to the revised Japanese criteria of ALF. This liver biopsy of the patient showed compatible to acute viral hepatitis and she immediately recovered without intensive care. She had no comorbid disorders. Read More

    MicroRNAs in Type 1 Diabetes: Complex Interregulation of the Immune System, β Cell Function and Viral Infections.
    Curr Diab Rep 2016 Dec;16(12):133
    School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia.
    Since the discovery of the first mammalian microRNA (miRNA) more than two decades ago, a plethora of miRNAs has been identified in humans, now amounting to more than 2500. Essential for post-transcriptional regulation of gene networks integral for developmental pathways and immune response, it is not surprising that dysregulation of miRNAs is often associated with the aetiology of complex diseases including cancer, diabetes and autoimmune disorders. Despite massive expansion of small RNA studies and extensive investigation in diverse disease contexts, the role of miRNAs in type 1 diabetes has only recently been explored. Read More

    Systematic Identification and Bioinformatic Analysis of MicroRNAs in Response to Infections of Coxsackievirus A16 and Enterovirus 71.
    Biomed Res Int 2016 24;2016:4302470. Epub 2016 Oct 24.
    Key Laboratory of Enteric Pathogenic Microbiology, Ministry of Health, Jiangsu Provincial Center for Disease Prevention and Control, No. 172 Jiangsu Road, Nanjing 210009, China.
    Hand, foot, and mouth disease (HFMD), mainly caused by coxsackievirus A16 (CVA16) and enterovirus 71 (EV71) infections, remains a serious public health issue with thousands of newly diagnostic cases each year since 2008 in China. The mechanisms underlying viral infection, however, are elusive to date. In the present study, we systematically investigated the host cellular microRNA (miRNA) expression patterns in response to CVA16 and EV71 infections. Read More

    Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis.
    Biomed Res Int 2016 20;2016:5697571. Epub 2016 Oct 20.
    Department of Pediatrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
    This study aimed to evaluate the clinical efficacy and safety of using the traditional Chinese herbal medicine Scutellaria baicalensis for the treatment of severe HFMD in 725 patients aged >1 year in a multicenter, retrospective analysis. The patients were divided into the S. baicalensis and ribavirin groups, and the temperatures, presence or absence of skin rashes and oral lesions, nervous system (NS) involvement, and viral loads of the patients, as well as the safety of the treatments, were evaluated. Read More

    Enterovirus-71 genotype C isolated in Peru between 2006 and 2009.
    J Clin Virol 2016 Dec 3;85:40-43. Epub 2016 Nov 3.
    U.S. Naval Medical Research Unit No. 6, Lima, Peru. Electronic address:
    Enterovirus-71 (EV71) was first isolated in California, United States in 1969, belongs to the genus Enterovirus, family Picornaviridae. Although infection normally causes mild, often undiagnosed illness, it can cause central nervous system infections that could turn fatal. Based on VP1 gene analysis, EV71 has been classified into six separate genotypes. Read More

    1 OF 1009