- Peng-Nien Huang,
- Jia-Rong Jheng,
- Jamie J Arnold,
- Jen-Ren Wang,
- Craig E Cameron,
- Shin-Ru Shih
PLoS Pathog 2017 May 17;13(5):e1006375. Epub 2017 May 17.
Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Positive-strand RNA virus infections can induce the stress-related unfolded protein response (UPR) in host cells. This study found that enterovirus A71 (EVA71) utilizes host UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1), a key endoplasmic reticulum protein (ER) involved in UPR, to enhance viral replication and virulence. EVA71 forms replication complexes (RCs) on cellular membranes that contain a mix of host and viral proteins to facilitate viral replication, but the components and processes involved in the assembly and function of RCs are not fully understood. Read More