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    50579 results match your criteria Enteroviral Infections

    1 OF 1012

    A prospective, comparative study of severe neurological and uncomplicated hand, foot and mouth forms of paediatric enterovirus 71 infections.
    Int J Infect Dis 2017 Apr 21. Epub 2017 Apr 21.
    Virology Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia. Electronic address:
    Objectives: In this study, we document the clinical characteristics and investigated risk factors for uncomplicated and severe forms of EV-A71 disease in Cambodian children.

    Methods: From March to July 2014 inclusive, all patients with suspicion of EV-A71 infection presenting to Kantha Bopha Hospitals in Phnom Penh and Siem Reap and confirmed by the Virology Unit at the Institut Pasteur du Cambodge were prospectively enrolled in this study. Throat swabs, rectal swabs and serum samples were collected from all consecutive patients with suspected EV-A71 infection. Read More

    The Clinical Significance of Neutrophilic Pleocytosis in Cerebrospinal Fluid in Patients with Viral Central Nervous System Infections.
    Int J Infect Dis 2017 Apr 20. Epub 2017 Apr 20.
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, 6431 Fannin St. MSB 2.112, Houston, Texas 77030, USA.
    Background: Viral central nervous system infections are typically characterized by a cerebrospinal fluid (CSF) lymphocytic pleocytosis. A CSF neutrophilic pleocytosis presentation has been described but its prognostic and clinical significance is unknown. The objectives of our study were to 1) compare the clinical and laboratory characteristics of viral CNS infections with CSF neutrophilic pleocytosis to those with a lymphocytic pleocytosis and 2) evaluate factors associated with an adverse clinical outcome. Read More

    Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo.
    Sci Rep 2017 Apr 20;7(1):935. Epub 2017 Apr 20.
    Healthy Aging Research Center, Chang Gung University, Guishan, Taoyuan, Taiwan.
    No effective drug is currently available for treatment of enterovirus 71 (EV71) infection. Schizonepeta tenuifolia Briq. (ST) has been used as a herbal constituent of traditional Chinese medicine. Read More

    Incidence of respiratory viral infections and associated factors among children attending a public kindergarten in Taipei City.
    J Formos Med Assoc 2017 Apr 15. Epub 2017 Apr 15.
    Departments of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background: Kindergarteners frequently encounter various infectious diseases, so surveillance of viral infectious diseases would provide information for their health promotion.

    Methods: We enrolled kindergarten attendees, age 2-5 years, during the academic years of 2006 and 2007 in a Taipei City kindergarten. Daily monitoring of illness and regular biweekly physical examinations were undertaken. Read More

    Influenza vaccine effectiveness estimates in the Dutch population from 2003 to 2014: The test-negative design case-control study with different control groups.
    Vaccine 2017 Apr 12. Epub 2017 Apr 12.
    Unit of PharmacoTherapy, -Epidemiology & -Economics (PTE(2)), Department of Pharmacy, University of Groningen, Groningen, The Netherlands; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
    Information about influenza vaccine effectiveness (IVE) is important for vaccine strain selection and immunization policy decisions. The test-negative design (TND) case-control study is commonly used to obtain IVE estimates. However, the definition of the control patients may influence IVE estimates. Read More

    Pediatric Acute Flaccid Paralysis: Enterovirus D68-Associated Anterior Myelitis.
    J Emerg Med 2017 Apr 12. Epub 2017 Apr 12.
    Department of Emergency Medicine, Naval Medical Center, Portsmouth, Virginia.
    Background: Enteroviral infections can cause acute flaccid paralysis secondary to anterior myelitis. Magnetic resonance imaging (MRI) is important in the diagnosis of this potentially devastating pediatric disease. Before the 2014 outbreak of Enterovirus D68 (EV-D68), the virus was considered a relatively benign disease. Read More

    Direct-acting antivirals and host-targeting strategies to combat enterovirus infections.
    Curr Opin Virol 2017 Apr 12;24:1-8. Epub 2017 Apr 12.
    Department of Infectious Diseases & Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. Electronic address:
    Enteroviruses (e.g., poliovirus, enterovirus-A71, coxsackievirus, enterovirus-D68, rhinovirus) include many human pathogens causative of various mild and more severe diseases, especially in young children. Read More

    Evaluation of TaqMan Array Card (TAC) for the Detection of Central Nervous System Infections in Kenya.
    J Clin Microbiol 2017 Apr 12. Epub 2017 Apr 12.
    Division of Global Health Protection, CDC-Kenya.
    Infections of the central nervous system (CNS) are often acute with significant morbidity and mortality. Routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-Saharan Africa. We developed a TaqMan Array Card (TAC) that detects multiple pathogens simultaneously from cerebrospinal fluid (CSF). Read More

    Real-time PCR Detection of the Most Common Bacteria and Viruses Causing Meningitis.
    Clin Lab 2017 Apr;63(4):827-832
    Background: Central nervous system (CNS) infections require prompt diagnosis, as the clinical condition progresses rapidly and may lead to severe permanent sequelae or death. The causative agents include viruses, bacteria, fungi, and parasites. In this study, samples with the diagnosis of CNS infection based on cerebrospinal fluid (CSF) sent to us from other hospitals/labs, were studied by multiplex real-time Polymerase Chain Reaction (PCR) method. Read More

    Impact of genetic changes, pathogenicity and antigenicity on Enterovirus- A71 vaccine development.
    Virology 2017 Jun 4;506:121-129. Epub 2017 Apr 4.
    Research Centre for Biomedical Sciences, Sunway University, Bandar Sunway, Kuala Lumpur, Selangor 47500, Malaysia. Electronic address:
    Enterovirus-A71 (EV-A71) is an etiological agent of the hand, foot and mouth disease (HFMD). EV-A71 infection produces high fever and ulcers in children. Some EV-A71 strains produce severe infections leading to pulmonary edema and death. Read More

    Surveillance Systems to Track Progress Toward Polio Eradication - Worldwide, 2015-2016.
    MMWR Morb Mortal Wkly Rep 2017 Apr 7;66(13):359-365. Epub 2017 Apr 7.
    Global measures to eradicate polio began in 1988; as of 2014, four of six World Health Organization (WHO) regions have been certified polio-free. Within the two endemic regions (African and Eastern Mediterranean), Nigeria, Afghanistan, and Pakistan have never interrupted transmission of wild poliovirus (WPV) (1). The primary means of detecting poliovirus transmission is surveillance for acute flaccid paralysis (AFP) among children aged <15 years, combined with collection and testing of stool specimens from persons with AFP for detection of WPV and vaccine-derived polioviruses (VDPVs) (viruses that differ genetically from vaccine viruses and can emerge in areas with low vaccination coverage and cause paralysis) in WHO-accredited laboratories within the Global Polio Laboratory Network (2,3). Read More

    Rule-Out Outbreak: 24-Hour Metagenomic Next-Generation Sequencing for Characterizing Respiratory Virus Source for Infection Prevention.
    J Pediatric Infect Dis Soc 2017 Apr 4. Epub 2017 Apr 4.
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington ; and.
    Background.: Metagenomic next-generation sequencing (mNGS) has been used to uncover unusual causes of infectious diseases but has not been used routinely for the investigation of putative nosocomial outbreaks. Here, we describe the use of mNGS during investigation of a cluster of human rhinovirus (HRV)-positive infections on a high-risk pulmonary ward. Read More

    A novel enterovirus species identified from severe diarrheal goats.
    PLoS One 2017 4;12(4):e0174600. Epub 2017 Apr 4.
    College of Veterinary Medicine, Jilin University, Changchun, Jilin, China.
    Backgrounds: The Enterovirus genus of the family of Picornaviridae consists of 9 species of Enteroviruses and 3 species of Rhinoviruses based on the latest virus taxonomy. Those viruses contribute significantly to respiratory and digestive disorders in human and animals. Out of 9 Enterovirus species, Enterovirus E-G are closely related to diseases affecting on livestock industry. Read More

    [Enterovirus infection during pregnancy: Underestimated cause of fetal and neonatal complications?]
    Gynecol Obstet Fertil Senol 2017 Apr 31;45(4):231-237. Epub 2017 Mar 31.
    Department of obstetrics and gynecology, hôpital Foch, 92120 Suresnes, France; EA2493, UFR des sciences de la santé Simone-Veil, université Versailles Saint-Quentin-en-Yvelines, 78180 Montigny-le-Bretonneux, France.
    Enteroviruses are responsible for about one billion infections every year in the world. The clinical expression is in the vast majority asymptomatic cases (90%). Its consequences during pregnancy are rarely described. Read More

    The emergence of enterovirus D68 in England in autumn 2014 and the necessity for reinforcing enterovirus respiratory screening.
    Epidemiol Infect 2017 Apr 3:1-10. Epub 2017 Apr 3.
    Public Health England (PHE),London,UK.
    In autumn 2014, enterovirus D68 (EV-D68) cases presenting with severe respiratory or neurological disease were described in countries worldwide. To describe the epidemiology and virological characteristics of EV-D68 in England, we collected clinical information on laboratory-confirmed EV-D68 cases detected in secondary care (hospitals), between September 2014 and January 2015. In primary care (general practitioners), respiratory swabs collected (September 2013-January 2015) from patients presenting with influenza-like illness were tested for EV-D68. Read More

    [Epidemiological and clinical characteristics of infants admitted to hospital due to human parechovirus infections: A prospective study in Spain].
    An Pediatr (Barc) 2017 Mar 29. Epub 2017 Mar 29.
    Unidad de Enterovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España; Red de Investigación Traslacional en Infectología Pediátrica (RITIP).
    Introduction: Human parechovirus (HPeV) is one of the recently described picornaviridae viruses that have been associated with fever of unknown origin (FUO), clinical sepsis, gastroenteritis, meningitis, or encephalitis in very young infants. The aim of this study is to describe the epidemiology and clinical features of these viruses.

    Patients And Methods: A prospective multicentre 3-year study was conducted in 12 hospitals in Spain. Read More

    Increased Risk of Tics in Children Infected with Enterovirus: A Nationwide Population-Based Study.
    J Dev Behav Pediatr 2017 Mar 27. Epub 2017 Mar 27.
    *Division of Infectious Diseases, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; †School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan; ‡Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; §College of Medicine, China Medical University, Taichung, Taiwan; ‖Research Center for Traditional Chinese Medicine, China Medical University & Hospital, Taichung, Taiwan; ¶Department of Biological Science and Technology, Meiho University, Pingtung, Taiwan; **Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; ††Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; ‡‡Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan.
    Objective: Both tics and enterovirus (EV) infections are common in children. The association between EV infections and tics has been seldom evaluated. The aim of this study was to evaluate the risk of diagnosed tics after EV infections in children. Read More

    Epidemiology of infectious encephalitis causes in 2016.
    Med Mal Infect 2017 Mar 22. Epub 2017 Mar 22.
    Direction des maladies infectieuses, santé publique France - "European Study Group for the Infections of the Brain (ESGIB)", 94410 Saint-Maurice, France.
    We performed a literature search in the Medline database, using the PubMed website. The incidence of presumably infectious encephalitis is estimated at 1.5-7 cases/100,000 inhabitants/year, excluding epidemics. Read More

    Serum IFN-γ-induced protein 10 (IP-10) as a biomarker for severity of acute respiratory infection in healthy adults.
    J Clin Virol 2017 May 16;90:32-37. Epub 2017 Mar 16.
    Department of Family Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, United States.
    Background: The inflammatory chemokine, interferon-gamma inducible protein of 10kDa (IP-10), is a biomarker associated with several conditions.

    Objectives: This study investigated serum concentrations of IP-10 in healthy individuals who developed acute respiratory infection (ARI). The hypothesis is that serum IP-10 concentrations correlate with ARI severity and detection of viral pathogens. Read More

    Herpes simplex virus-1 and cytomegalovirus DNAs detection in the inner ear of implanted patients with non-congenital infection.
    Acta Otolaryngol 2017 Mar 23:1-6. Epub 2017 Mar 23.
    a Department of Head and Neck Surgery, Institute of Otorhinolaryngology , Catholic University of Sacred Heart , Rome , Italy.
    Conclusions: The detection of cytomegalovirus (CMV) and herpes simplex virus-1 (HSV-1) genome in perilymph of patients with negative serology or clinical history for congenital infections supports the hypothesis that Herpesviridae, even after acquired postnatal infections, could remain in latent phase in the spiral ganglion and damage the cochlea by a possible subsequent reactivation. Further studies are needed to identify the markers of such reactivation.

    Objective: To identify the presence of certain viral species in the endolabyrinthic fluid of deaf patients with non-congenital infection. Read More

    Etiological agents of viral meningitis in children from a dengue-endemic area, Southeast region of Brazil.
    J Neurol Sci 2017 Apr 16;375:390-394. Epub 2017 Feb 16.
    Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil. Electronic address:
    Meningitis is a disease with a global distribution that constitutes a worldwide burden, with viruses as the primary etiologic agents. The range of viral meningitis severity depends mainly on age, immune status and etiological agent. The aim of this work was to investigate the suspected cases of viral meningitis using molecular techniques to confirm the viral infection. Read More

    Best practices to prevent transmission and control outbreaks of hand, foot, and mouth disease in childcare facilities: a systematic review.
    Hong Kong Med J 2017 Apr 17;23(2):177-90. Epub 2017 Mar 17.
    Communicable Diseases Policy Research Group, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, Bangkok Office, Thailand.
    Introduction: Hand, foot, and mouth disease continues to cause seasonal epidemics in the Asia-Pacific Region. Since the current Enterovirus 71 vaccines do not provide cross-protection for all Enterovirus species that cause hand, foot, and mouth disease, there is an urgent need to identify appropriate detection tools and best practice to prevent its transmission and to effectively control its outbreaks. This systematic review aimed to identify characteristics of outbreak and assess the impact and effectiveness of detection tools and public health preventive measures to interrupt transmission. Read More

    [Acute myelitis and viral hepatitis: about a case].
    Pan Afr Med J 2016 4;25:71. Epub 2016 Oct 4.
    Service de Neurologie, Hôpital Militaire d'Instruction Mohamed V, Rabat, Maroc.
    Hepatitis A virus can manifest with severe and unusual neurological attack. We report the case of a 59-year old man with balance disorder associated with lower limb paresthesias and sphincter disorders. Spinal MRI was in favor of acute myelitis. Read More

    Antiviral activity of cationic amphiphilic drugs.
    Expert Rev Anti Infect Ther 2017 May 20;15(5):483-492. Epub 2017 Mar 20.
    a Department of Molecular Medicine , University of Padova , Padova , Italy.
    Introduction: Emerging and reemerging viral infections represent a major concern for human and veterinary public health and there is an urgent need for the development of broad-spectrum antivirals. Areas covered: A recent strategy in antiviral research is based on the identification of molecules targeting host functions required for infection of multiple viruses. A number of FDA-approved drugs used to treat several human diseases are cationic amphiphilic drugs (CADs) that have the ability to accumulate inside cells affecting several structures/functions hijacked by viruses during infection. Read More

    Paediatric Active Enhanced Disease Surveillance inaugural annual report, 2014.
    Commun Dis Intell Q Rep 2016 Sep 30;40(3):E391-E400. Epub 2016 Sep 30.
    Deputy Director, National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Kids Research Institute, The Children's Hospital at Westmead; New South Wales.
    Introduction: The Paediatric Active Enhanced Disease Surveillance (PAEDS) network is a hospital-based active surveillance system employing prospective case ascertainment of selected uncommon vaccine preventable diseases and potential adverse events following immunisation (AEFI). PAEDS enhances other Australian surveillance systems by providing prospective detailed clinical and laboratory data for the same child.

    Methods: Specialist surveillance nurses screen hospital admissions, emergency department records, laboratory and other data, to prospectively identify hospitalised children aged under 15 years in 5 paediatric tertiary referral hospitals in New South Wales, Victoria, South Australia, Western Australia and Queensland. Read More

    Enhancing enterovirus A71 vaccine production yield by microcarrier profusion bioreactor culture.
    Vaccine 2017 Mar 6. Epub 2017 Mar 6.
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan; Graduate Institute of Immunology, China Medical University, Taichung, Taiwan.
    Hand, foot and mouth diseases (HFMD) are mainly caused by Enterovirus A71 (EV-A71) infections. Clinical trials in Asia conducted with formalin-inactivated EV-A71 vaccine candidates produced from serum-free Vero cell culture using either roller bottle or cell factory technology, are found to be safe and highly efficacious. To increase vaccine yields and reduce the production costs, the bioprocess improvement for EV-A71 vaccine manufacturing is currently being investigated. Read More

    In vivo T2* weighted MRI visualizes cardiac lesions in murine models of acute and chronic viral myocarditis.
    PLoS One 2017 6;12(3):e0172084. Epub 2017 Mar 6.
    Department of Molecular Pathology, Institute for Pathology and Neuropathology, University Hospital Tuebingen, Tuebingen, Germany.
    Objective: Acute and chronic forms of myocarditis are mainly induced by virus infections. As a consequence of myocardial damage and inflammation dilated cardiomyopathy and chronic heart failure may develop. The gold standard for the diagnosis of myocarditis is endomyocardial biopsies which are required to determine the etiopathogenesis of cardiac inflammatory processes. Read More

    Response to a Large Polio Outbreak in a Setting of Conflict - Middle East, 2013-2015.
    MMWR Morb Mortal Wkly Rep 2017 Mar 3;66(8):227-231. Epub 2017 Mar 3.
    As the world advances toward the eradication of polio, outbreaks of wild poliovirus (WPV) in polio-free regions pose a substantial risk to the timeline for global eradication. Countries and regions experiencing active conflict, chronic insecurity, and large-scale displacement of persons are particularly vulnerable to outbreaks because of the disruption of health care and immunization services (1). A polio outbreak occurred in the Middle East, beginning in Syria in 2013 with subsequent spread to Iraq (2). Read More

    Enterovirus D68-Associated Community-Acquired Pneumonia in the Pediatric Age Group.
    Curr Infect Dis Rep 2017 Mar;19(3):12
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.
    Purpose Of Review: This review summarizes the current knowledge regarding the role of Enterovirus D68 (EV-D68) in community-acquired pneumonia (CAP) in children.

    Recent Findings: EV-D68 is an emergent viral pathogen. Since its first isolation in 1962 in California in four children suffering from CAP and bronchiolitis, EV-D68 has been rarely detected from respiratory specimens. Read More

    A Neonatal Murine Model of Coxsackievirus A6 Infection for Evaluation of Antiviral and Vaccine Efficacy.
    J Virol 2017 May 13;91(9). Epub 2017 Apr 13.
    Institute of Pathogen Biology, Taishan Medical College, Taian, Shandong, China
    Hand, foot, and mouth disease (HFMD) is a global health concern. Family Picornaviridae members, particularly enterovirus A71 (EVA71) and coxsackievirus A16 (CVA16), are the primary etiological agents of HFMD; however, a third enterovirus A species, CVA6, has been recently associated with epidemic outbreaks. Study of the pathogenesis of CVA6 infection and development of antivirals and vaccines are hindered by a lack of appropriate animal models. Read More

    Serosurveillance of hepatitis A in a region which adopted the universal mass vaccination.
    Medicine (Baltimore) 2017 Mar;96(9):e5884
    Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Bari, Italy.
    Hepatitis A is a common infectious disease worldwide that was endemic in many regions of Southern Italy, such as Apulia region. After a large hepatitis A outbreak occurred between 1996 and 1997, in Apulia an active-free immunization program that was targeted to new-borns and adolescents was started. The aim of this study is to investigate the hepatitis A seroprevalence in the adult Apulian population 18 years after the immunization program introduction, in order to evaluate the risk of new epidemics onset. Read More

    A retrospective study of viral central nervous system infections: relationship amongst aetiology, clinical course and outcome.
    Infection 2017 Apr 24;45(2):227-231. Epub 2017 Feb 24.
    Infectious and Tropical Diseases Unit, Amedeo di Savoia Hospital, Corso Svizzera 164, Turin, Italy.
    Purpose: To describe the clinical pattern of viral central nervous system (CNS) infections and compare meningitis and encephalitis.

    Methods: This is a retrospective study reporting the clinical characteristics and outcome of 138 cases of viral meningitis and meningoencephalitis in a real life experience at a referral centre in Turin, Northern Italy.

    Results: Enteroviruses were predominant in younger patients who were mainly presenting with signs of meningitis, had shorter hospital admission and absence of complications, whereas herpesviruses had more often signs of encephalitis, were more frequent in elderly patients, had longer hospital admission and frequent complications and sequelae. Read More

    Continued Endemic Wild Poliovirus Transmission in Security-Compromised Areas - Nigeria, 2016.
    MMWR Morb Mortal Wkly Rep 2017 Feb 24;66(7):190-193. Epub 2017 Feb 24.
    On August 10, 2016, 2 years after the most recent wild poliovirus (WPV) case was reported in Nigeria (in July 2014) (1), two WPV cases were reported in the northeastern state of Borno, which has been severely affected by insurgency-related insecurity since 2013. On September 9 and 26, 2016, two additional WPV cases were reported in Borno in children whose families migrated from security-compromised, inaccessible areas of the state. All four cases were WPV serotype 1 (WPV1), with genetic differences indicating prolonged undetected transmission. Read More

    Acute respiratory infections among returning Hajj pilgrims-Jordan, 2014.
    J Clin Virol 2017 Apr 8;89:34-37. Epub 2017 Feb 8.
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
    Background: The emergence of Middle East Respiratory Syndrome coronavirus (MERS-CoV) has prompted enhanced surveillance for respiratory infections among pilgrims returning from the Hajj, one of the largest annual mass gatherings in the world.

    Objectives: To describe the epidemiology and etiologies of respiratory illnesses among pilgrims returning to Jordan after the 2014 Hajj.

    Study Design: Surveillance for respiratory illness among pilgrims returning to Jordan after the 2014 Hajj was conducted at sentinel health care facilities using epidemiologic surveys and molecular diagnostic testing of upper respiratory specimens for multiple respiratory pathogens, including MERS-CoV. Read More

    Comparison of Luminex NxTAG Respiratory Pathogen Panel and xTAG Respiratory Viral Panel FAST Version 2 for the Detection of Respiratory Viruses.
    Ann Lab Med 2017 May;37(3):267-271
    Department of Laboratory Medicine, National University Hospital, Singapore.
    Owing to advancements in molecular diagnostics, recent years have seen an increasing number of laboratories adopting respiratory viral panels to detect respiratory pathogens. In December 2015, the NxTAG respiratory pathogen panel (NxTAG RPP) was approved by the United States Food and Drug Administration. We compared the clinical performance of this new assay with that of the xTAG respiratory viral panel (xTAG RVP) FAST v2 using 142 clinical samples and 12 external quality assessment samples. Read More

    [Genotype distribution of human enteroviruses isolated from swage in Shanghai during year 2013-2014].
    Zhonghua Yu Fang Yi Xue Za Zhi 2017 Feb;51(2):154-159
    Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
    Objective: To explore the time and genotype distribution of human enterovirus (HEV) isolated from sewage in Shanghai in 2013-2014. Methods: One sewage sample each was collected from two local sewage plants located in Minhang District and Jiading District on the same day at the day 24-28 of every month from 2013 to 2014. Each sample weighed 1 L. Read More

    [Human enterovirus infection status and clinical characteristics of 274 patients with viral encephalitis in Henan Province, 2011-2012].
    Zhonghua Yu Fang Yi Xue Za Zhi 2017 Feb;51(2):150-153
    Henan Center for Disease Control and Prevention, Zhengzhou 450016, China.
    Objective: To investigate human enterovirus (HEV) infection and clinical characteristics of viral encephalitis patients in Pingdingshan, Henan Province. Methods: Cerebrospinal fluid specimens and epidemiological information were collected from 274 viral encephalitis patients in the departments of pediatrics and neurology in hospitals in Pingdingshan, Henan Province, from April 2011 to August 2012. Patients with bacterial infections were excluded from the study. Read More

    Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A.
    Sci Rep 2017 Feb 20;7:42902. Epub 2017 Feb 20.
    Unit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China.
    Suramin was previously shown to bind to the EV-A71 capsid through its naphthalenetrisulfonic acid groups, thereby reducing virus-cell binding and inhibiting viral replication. Here, we identify VP1-145 as the critical amino acid that accounts for the differential sensitivity of EVA-71 viruses to suramin. A single Q or G to E substitution at VP1-145 results in an approximately 30-fold shift of IC50 or IC90 values reproducing the inhibition profile observed with field isolates expressing either the 145Q or E mutation. Read More

    Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CL(Pro) inhibitors.
    Antiviral Res 2017 May 17;141:101-106. Epub 2017 Feb 17.
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan. Electronic address:
    Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory illness with fever, cough and shortness of breath. Up to date, it has resulted in 1826 human infections, including 649 deaths. Analogous to picornavirus 3C protease (3C(pro)), 3C-like protease (3CL(pro)) is critical for initiation of the MERS-CoV replication cycle and is thus regarded as a validated drug target. Read More

    Comparative analysis of viral shedding in pediatric and adult subjects with central nervous system-associated enterovirus infections from 2013 to 2015 in Switzerland.
    J Clin Virol 2017 Apr 7;89:22-29. Epub 2017 Feb 7.
    Laboratory of Virology, Infectious Diseases Service, University Hospitals of Geneva, 4 Rue Gabrielle-Perret-Gentil, 1211 Geneva 14, Switzerland; University of Geneva Medical School, 1 Rue Michel-Servet, 1211 Geneva 4, Switzerland.
    Background: Several enterovirus (EV) genotypes can result in aseptic meningitis, but their routes of access to the central nervous system remain to be elucidated and may differ between the pediatric and adult populations.

    Objective: To assess the pattern of viral shedding in pediatric and adult subjects with acute EV meningitis and to generate EV surveillance data for Switzerland.

    Study Design: All pediatric and adult subjects admitted to the University Hospitals of Geneva with a diagnosis of EV meningitis between 2013 and 2015 were enrolled. Read More

    Rapid detection and quantification of Enterovirus 71 by a portable surface plasmon resonance biosensor.
    Biosens Bioelectron 2017 Jun 21;92:186-191. Epub 2017 Jan 21.
    Department of Electronic Engineering, Chang Gung University, Taoyuan 33002, Taiwan; Center for Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan; Division of Pediatric Infectious Disease, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou 33305, Taiwan; Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan. Electronic address:
    This study presents the first report on a label-free detection and rapid quantification method for human enterovirus 71 (EV71) using a portable surface plasmon resonance (SPR) system. The SPR sensor instrument was configured to run on low power in a miniaturized platform to improve the device portability for a wider application both in laboratories and in the field. A color tunable organic light emitting diode in red spectrum was attached on a trapezoidal prism for the disposable light source module. Read More

    An Outbreak of Acute Hepatitis Caused by Genotype IB Hepatitis A Viruses Contaminating the Water Supply in Thailand.
    Intervirology 2016 17;59(4):197-203. Epub 2017 Feb 17.
    National Institute of Health, Ministry of Public Health, Nonthaburi, Thailand.
    Background: In 2000, an outbreak of acute hepatitis A was reported in a province adjacent to Bangkok, Thailand.

    Aims: To investigate the cause of the 2000 hepatitis A outbreaks in Thailand using molecular epidemiological analysis.

    Methods: Serum and stool specimens were collected from patients who were clinically diagnosed with acute viral hepatitis. Read More

    Adenovirus type 4 respiratory infections with a concurrent outbreak of coxsackievirus A21 among United States Army Basic Trainees, a retrospective viral etiology study using next-generation sequencing.
    J Med Virol 2017 Feb 15. Epub 2017 Feb 15.
    Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland.
    Human adenoviruses (HAdV), in particular types 4 and 7, frequently cause acute respiratory disease (ARD) during basic military training. HAdV4 and HAdV7 vaccines reduced the ARD risk in U.S. Read More

    Coxsackie Myocarditis and Hepatitis with Reactivated Epstein-Bar Virus (EBV): A Case Report.
    Am J Case Rep 2017 Feb 15;18:166-169. Epub 2017 Feb 15.
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
    BACKGROUND Myocarditis, defined as inflammation of myocardial tissue of the heart, is an uncommon cardiac presentation and is due to a variety of causes. It affects 1% of the US population, 50% of which is caused by coxsackie B virus. Cardiac tissue is the prime target, and destruction of myocardium results in cardiac failure with fluid overload. Read More

    Clinical Course of Enterovirus D68 in Hospitalized Children.
    Pediatr Infect Dis J 2017 Mar;36(3):290-295
    From the *Department of Pediatrics, Children's Mercy Hospital, †Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, and ‡University of Missouri-Kansas City, School of Medicine, Kansas City, Missouri.
    Background: Enterovirus D68 (EV-D68) has been sporadically reported as a cause of respiratory tract infections. In 2014, an international outbreak of EV-D68 occurred and caused severe respiratory disease in the pediatric population.

    Methods: A retrospective chart review was performed of children admitted to Children's Mercy Hospital from August 1, 2014, to September 15, 2014, with positive multiplex polymerase chain reaction testing for EV/rhinovirus (RV). Read More

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