328 results match your criteria Enteropathic Arthropathies


Classifications and imaging of juvenile spondyloarthritis.

J Ultrason 2018 ;18(74):224-233

University of Nis, Faculty of Medicine, Department of Pediatric Rheumatology and Immunology, Serbia.

Juvenile spondyloarthritis may be present in at least 3 subtypes of juvenile idiopathic arthritis according to the classification of the International League of Associations for Rheumatology. By contrast with spondyloarthritis in adults, juvenile spondyloarthritis starts with inflammation of peripheral joints and entheses in the majority of children, whereas sacroiliitis and spondylitis may develop many years after the disease onset. Peripheral joint involvement makes it difficult to differentiate juvenile spondyloarthritis from other juvenile idiopathic arthritis subtypes. Read More

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January 2018
2 Reads

Spondyloarthropathy in vertebrae of the aquatic Cretaceous snake Lunaophis aquaticus, and its first recognition in modern snakes.

Naturwissenschaften 2018 Aug 14;105(9-10):51. Epub 2018 Aug 14.

Oxford University Museum of Natural History, Oxford, UK.

Inflammatory arthritis is documented for the first time in snakes. Ossification of the intervertebral capsule and zygapophyseal joints resulting in segmental vertebral fusion was observed in the aquatic Cretaceous snake Lunaophis aquaticus. Such pathologic alterations are pathognomonic for the spondyloarthropathy form of inflammatory arthritis. Read More

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August 2018
4 Reads

Balneotherapy in chronic inflammatory rheumatic diseases-a narrative review.

Int J Biometeorol 2018 Dec 1;62(12):2065-2071. Epub 2018 Oct 1.

Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy.

Since ancient time, thermal baths and mudpacks have been used as treatments for rheumatic diseases and other musculoskeletal complaints. Despite basic researches suggest an anti-inflammatory effect of spa therapy, there is no consensus about the benefits of balneotherapy in patients with chronic inflammatory rheumatic diseases. The aim of this review is to summarize the currently available information on clinical effects of balneotherapy in these diseases. Read More

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December 2018
2 Reads

A Single-Tube, EuroClonality-Inspired, TRG Clonality Multiplex PCR Aids Management of Patients with Enteropathic Diseases, including from Formaldehyde-Fixed, Paraffin-Embedded Tissues.

J Mol Diagn 2018 Sep 28. Epub 2018 Sep 28.

Université Paris Descartes-Sorbonne Paris Cité, Paris, France; Laboratory Hematology, Hôpital Necker-Enfants Malades, Assistance Publique des Hôpitaux de Paris, Paris, France; INSERM UMR1151 and Institut Necker-Enfants Malades, Paris, France; Centre national Expert des Lymphomes Associés à la maladie Coeliaque, , Hôpital Necker-Enfants Malades, Assistance Publique des Hôpitaux de Paris, Paris, France. Electronic address:

Celiac disease is a chronic inflammation of the small intestine with villous atrophy that can become refractory to a gluten-free diet. Two categories of refractory celiac disease can be distinguished by the phenotype of intraepithelial lymphocytes and the status of TRG genes. Their distinction is important because 30% to 50% of type II but only 0% to 14% of type I evolve to an aggressive enteropathy-associated T-cell lymphoma and therefore require intensive treatment. Read More

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September 2018
6 Reads
4.850 Impact Factor

Ocular features of the HLA-B27-positive seronegative spondyloarthropathies.

Curr Opin Ophthalmol 2018 Nov;29(6):552-557

Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin Eye Institute, Milwaukee, Wisconsin, USA.

Purpose Of Review: The seronegative spondyloarthropathies are a closely related group of inflammatory diseases that include ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthritis, inflammatory bowel disease and undifferentiated spondyloarthritis. This review focuses on the spectrum of ocular manifestations associated with these diseases and the current approaches in treating these ocular manifestations. It also highlights the role ophthalmologists can play in identifying and appropriately treating human leukocyte antigen B27 (HLA-B27) associated uveitis and the associated spondyloarthropathies in order to limit ocular and systemic morbidity. Read More

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November 2018
8 Reads

IL-17 in the immunopathogenesis of spondyloarthritis.

Nat Rev Rheumatol 2018 Aug;14(8):453-466

Department of Rheumatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Spondyloarthritis (SpA) is a term that refers to a group of inflammatory diseases that includes psoriatic arthritis, axial SpA and nonradiographic axial SpA, reactive arthritis, enteropathic arthritis and undifferentiated SpA. The disease subtypes share clinical and immunological features, including joint inflammation (peripheral and axial skeleton); skin, gut and eye manifestations; and the absence of diagnostic autoantibodies (seronegative). The diseases also share genetic factors. Read More

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August 2018
11 Reads

Nature versus nurture in the spectrum of rheumatic diseases: Classification of spondyloarthritis as autoimmune or autoinflammatory.

Autoimmun Rev 2018 Sep 11;17(9):935-941. Epub 2018 Jul 11.

Cellular Diagnostics & Cell Therapy, Central Diagnostic Laboratory, Maastricht University Medical Centre, Maastricht, the Netherlands. Electronic address:

Spondyloarthritides (SpA) include inflammatory joint diseases with various clinical phenotypes that may also include the axial skeleton and/or entheses. SpA include psoriatic arthritis, reactive arthritis, enteropathic arthritis and ankylosing spondylitis; the latter is frequently associated with extra-articular manifestations, such as uveitis, psoriasis, and inflammatory bowel disease. SpA are associated with the HLA-B27 allele and recognize T cells as key pathogenetic players. Read More

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September 2018
12 Reads
7.930 Impact Factor

The Seronegative Spondyloarthropathies.

Prim Care 2018 Jun;45(2):271-287

Department of Rheumatology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA. Electronic address:

The seronegative spondyloarthropathies are a group of five diseases characterized by inflammatory oligoarticular arthritis, enthesitis, and axial involvement. They have an increased incidence of the HLA-B27 gene. They are commonly associated with extra-articular features including involvement of the skin, eyes, and gastrointestinal tract. Read More

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June 2018
7 Reads

An unexpected cause of sacroiliitis in a patient with gout and chronic psoriasis with inflammatory arthritis: a case report.

BMC Musculoskelet Disord 2018 Apr 20;19(1):126. Epub 2018 Apr 20.

Rheumatology Department, Cork University Hospital, Cork, Ireland.

Background: Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis and reactive arthritis. Inflammatory back pain can be caused by many other conditions like infection and crystal deposition such as gout. Read More

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April 2018
5 Reads

Anti-alpha-enolase antibodies in Behçet's disease: a marker of mucocutaneous and articular disease activity?

Clin Exp Rheumatol 2018 Feb 7. Epub 2018 Feb 7.

Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Brazil.

Objectives: To assess IgM anti-alpha-enolase antibodies (AAEA) in systemic Behçet's disease (BD) and its possible association with clinical manifestations and disease activity.

Methods: Ninety-seven consecutively selected BD patients were compared to 36 enteropathic spondyloarthritis (ESpA) [24 Crohn's disease (CD) and 12 ulcerative colitis (UC)] patients and 87 healthy controls. IgM AAEA was detected by immunoblotting. Read More

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February 2018
13 Reads

One year in review 2017: spondyloarthritis.

Clin Exp Rheumatol 2018 Jan-Feb;36(1):1-14. Epub 2018 Feb 5.

GenOMeC PhD, University of Siena; and Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.

The term spondyloarthritis (SpA) represents a condition characterised by a broad spectrum of clinical manifestations, laboratory abnormalities and imaging features; in particular, SpA is an inflammatory condition in which both peripheral and axial joints might be affected. The majority of people with this disease have either psoriatic arthritis or axial spondyloarthritis, which includes ankylosing spondylitis. Less common subgroups are enteropathic SpA, which is associated with inflammatory bowel diseases (Crohn's disease and ulcerative colitis), reactive arthritis, which can occur in people following gastrointestinal or genitourinary infections and undifferentiated SpA, that does not meet the diagnostic criteria of the other subgroups at onset, but that may evolve to do so later. Read More

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April 2018
20 Reads

Spondyloarthritis features in zymosan-induced SKG mice.

Joint Bone Spine 2018 Oct 29;85(5):583-591. Epub 2017 Nov 29.

Division of Rheumatology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea. Electronic address:

Objectives: Spondyloarthritis (SpA) encompasses a group of disorders including ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and enteropathic arthritis. SpA pathogenesis is still not well understood. Animal models are important for studying disease mechanisms and identifying new therapeutic agents. Read More

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October 2018
5 Reads

Adalimumab efficacy in enteropathic spondyloarthritis: A 12-mo observational multidisciplinary study.

World J Gastroenterol 2017 Oct;23(39):7139-7149

Dipartimento Scienze Cliniche e Molecolari, Clinica Medica, Università Politecnica delle Marche, Ancona 60126, Italy.

Aim: To report adalimumab (Ada) efficacy on articular-gastrointestinal disease and health-related quality of life (HRQoL) in patients with enteropathic spondyloarthritis (ES).

Methods: A cohort of 52 patients with ES was evaluated in the departments of gastroenterology and internal medicine. At baseline, all patients underwent assessment by an integrated gastro-rheumatologic evaluation of articular and gastrointestinal activity, as well patient reported outcomes (PROs) of the HRQoL questionnaires. Read More

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October 2017
14 Reads

Diabetes Mellitus and the Colon.

Curr Treat Options Gastroenterol 2017 Dec;15(4):460-474

Michigan Medicine at the University of Michigan, 3912 Taubman Center, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.

Opinion Statement: Diabetes mellitus (DM) can affect the structure and function of the colon promoting commonly encountered lower gastrointestinal symptoms such as constipation, diarrhea, abdominal distention, bloating, and abdominal pain. Specific colonic disorders for which adults with DM are at greater risk include chronic constipation, enteropathic diarrhea, colorectal cancer (CRC), inflammatory bowel disease, microscopic colitis, and Clostridium difficile colitis. Smooth muscle structure and function, density of the interstitial cells of Cajal, and the health and function of the autonomic and enteric nerves of the colon are all potential affected by DM. Read More

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December 2017
8 Reads

Fever as an initial manifestation of spondyloarthritis: A retrospective study.

PLoS One 2017 14;12(9):e0184323. Epub 2017 Sep 14.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.

Objectives: We aimed to evaluate a wide spectrum of clinical features of adult patients with spondyloarthritis (SpA) whose initial manifestation was fever, using the Assessment of SpondyloArthritis international Society (ASAS) classification criteria.

Methods: We retrospectively collected the electronic medical records of hospitalized SpA patients who initially presented to the Severance Hospital (Seoul, Korea) with fever from January 2010 to May 2016. As a control group, we also recruited one-hundred consecutive patients who were diagnosed with SpA in our outpatient clinic. Read More

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October 2017
12 Reads

Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal Anti-inflammatory Drug Induced Reduction in T Regulatory Cells.

Front Immunol 2017 23;8:1000. Epub 2017 Aug 23.

Top Institute Food and Nutrition, Wageningen, Netherlands.

Orally ingested bacteria interact with intestinal mucosa and may impact immunity. However, insights in mechanisms involved are limited. In this randomized placebo-controlled cross-over trial, healthy human subjects were given supplementation (strain TIFN101, CIP104448, or WCFS1) or placebo for 7 days. Read More

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August 2017
12 Reads

Conventional Radiology in Spondyloarthritis.

Radiol Clin North Am 2017 Sep 12;55(5):943-966. Epub 2017 Jun 12.

Department of Radiology, University of Foggia, Viale Luigi Pinto 1, Foggia 71100, Italy; Department of Radiology, Scientific Institute, Casa Sollievo della Sofferenza Hospital, Viale Cappuccini 1, San Giovanni Rotondo, Foggia 71013, Italy.

Spondyloarthritides are of a group of inflammatory rheumatic diseases, with negative rheumatoid factor, associated with the HLA-B27 gene. They comprise ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and enteropathic-related spondylitis. The presence of sacroiliitis represents the most characteristic feature of these disorders and is an important criterion in diagnosis. Read More

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September 2017
11 Reads

Tropical Enteropathies.

Curr Gastroenterol Rep 2017 Jul;19(7):29

Blizard Institute, Barts & The London School of Medicine, Queen Mary University of London, Newark Street, London, E1 2AT, UK.

Purpose Of Review: The term 'tropical enteropathy' originated in observations in the 1960s that small intestinal morphology and function differed in the tropics from the norms found in temperate climates. It was subsequently shown that this enteropathy is more closely related to environmental conditions than latitude, and it was re-labelled 'environmental enteropathy'. It is now recognised that environmental enteropathy (also now called environmental enteric dysfunction) has implications for the health and linear growth of children in low- and middle-income countries, and it may underlie poor responses to oral vaccination in these countries. Read More

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July 2017
10 Reads

Overcoming the exacerbating effects of ranitidine on NSAID-induced small intestinal toxicity with quercetin: Providing a complete GI solution.

Chem Biol Interact 2017 Jun 8;272:53-64. Epub 2017 Apr 8.

Department of Pharmacology and Toxicology, B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Thaltej, Ahmedabad, Gujarat, 380054, India. Electronic address:

There is a need to find/discover novel leads to treat complex and/or multi-factorial-pathogenic disease(s) like Nonsteroidal anti-inflammatory drugs (NSAID)-induced gastroenteropathy or gastrointestinal (GI) toxicity as it has emerged as an important medical and socioeconomic problem. There is no approved therapeutic strategy to prevent NSAID-induced enteropathic damage and highly effective gastro-protective drugs such as ranitidine hydrochloride (RAN) exacerbate it. In this purview, the multi target drug discovery approach (MTDD), combination approach and hit to lead strategies based on the foundation of ethnopharmacology and/or reverse pharmacology holds strong potential. Read More

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June 2017
3 Reads

Prevalence of psoriatic arthritis and costs generated by treatment of psoriatic arthritis patients in the public health system - the case of Poland.

Reumatologia 2016;54(6):278-284. Epub 2016 Dec 30.

Department of Internal Medicine and Rheumatology, Military Institute of Medicine Warsaw, Poland.

Objective: The objective of the study was to analyse the prevalence of psoriatic arthritis (PsA) in Poland and to assess the costs generated by treatment of PsA patients in the system of public healthcare.

Material And Methods: The analysis was based on the database of the public payer, the National Health Fund (NFZ). PsA was defined by the diagnostic ICD-10 codes M07 (Enteropathic arthropathies) and L40. Read More

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December 2016
16 Reads

Evidence of IL-17 producing innate lymphoid cells in peripheral blood from patients with enteropathic spondyloarthritis.

Clin Exp Rheumatol 2016 Nov-Dec;34(6):1085-1093. Epub 2016 Oct 21.

Gastrointestinal Unit, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.

Objectives: Both the innate and the adaptive immune responses contribute to the onset of chronic inflammation in spondyloarthritis (SpA). The association between SpA and inflammatory bowel disease (IBD, enteropathic SpA-ESpA) has been largely established and suggests a shared pathophysiology. There is evidence that innate lymphoid cells (ILC) are involved in the pathogenesis of both SpA and IBD while no evidence has been reported to date on ESpA. Read More

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June 2017
32 Reads

Co-administration of quercetin with pantoprazole sodium prevents NSAID-induced severe gastroenteropathic damage efficiently: Evidence from a preclinical study in rats.

Exp Toxicol Pathol 2017 Jan 22;69(1):17-26. Epub 2016 Oct 22.

Department of Pharmacology and Toxicology, B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Thaltej, Ahmedabad, Gujarat 380054, India. Electronic address:

Management of Nonsteroidal anti-inflammatory drug (NSAID)-induced gastroenteropathy has emerged as a major medical and socioeconomic problem mainly because the highly efficacious gastroprotective drugs i.e. proton pump inhibitors (PPIs) like pantoprazole sodium (PTZ), worsen the NSAID-induced enteropathic damage and lack of approved therapeutic strategies/interventions to prevent this damage. Read More

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January 2017
2 Reads

Variant detection and runs of homozygosity in next generation sequencing data elucidate the genetic background of Lundehund syndrome.

BMC Genomics 2016 08 2;17:535. Epub 2016 Aug 2.

Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover Foundation, Hanover, Germany.

Background: The Lundehund is a highly specialized breed characterized by a unique flexibility of the joints and polydactyly in all four limbs. The extremely small population size and high inbreeding has promoted a high frequency of diseased dogs affected by the Lundehund syndrome (LS), a severe gastro-enteropathic disease.

Results: Comprehensive analysis of bead chip and whole-genome sequencing data for LS in the Lundehund resulted in a genome-wide association signal on CFA 34 and LS-specific runs of homozygosity (ROH) in this region. Read More

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August 2016
12 Reads

Safety, efficacy and immunogenicity of switching from innovator to biosimilar infliximab in patients with spondyloarthritis: a 6-month real-life observational study.

Immunol Res 2017 02;65(1):419-422

Allergology and Immunology Laboratory, S.Giovanni di Dio Hospital, Florence, Italy.

Biosimilar infliximab (INX) was recently approved by the European Medicine Agency for the treatment of rheumatoid arthritis, ankylosing spondylitis (AS), Crohn's disease, ulcerative colitis, psoriatic arthritis (PsA), and psoriasis on the grounds that its pharmacokinetics, safety, and efficacy were comparable to those of innovator INX. The aim of this study was to investigate the real-life efficacy, safety, and immunogenicity of switching from innovator to biosimilar INX in patients with spondyloarthritis (SpA). Forty-one patients attending three Italian rheumatology centres with a previous diagnosis of SpA and clinically inactive or moderate disease activity (ASDAS-CRP < 2. Read More

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February 2017
44 Reads

A case of enteropathic arthritis successfully treated with methotrexate.

Nihon Rinsho Meneki Gakkai Kaishi 2016 ;39(3):219-22

Institute of Rheumatology, Tokyo Women's Medical University.

  We report a 36-year-old male patient who suffered from polyarthritis after the remission of ulcerative colitis. He was diagnosed with enteropathic arthritis type 2, against which methotrexate was effective. Read More

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March 2017
5 Reads

Dactylitis in enteropathic spondyloarthritis.

Clin Exp Rheumatol 2016 Sep-Oct;34(5):842-847. Epub 2016 Apr 15.

Rheumatology Research Unit, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.

Objectives: Dactylitis has long been recognised as one of the significant features of spondyloarthropathies. In the literature, the prevalence of dactylitis in enteropathic spondyloarthritis (EASpA) ranges between 2% and 4%. The aim of this study was to identify the prevalence of dactylitis in EASpA patients and to investigate its association with clinical subset and with articular and bowel disease activity. Read More

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January 2017
19 Reads

Disseminated Mycobacterium marinum Infection With a Destructive Nasal Lesion Mimicking Extranodal NK/T Cell Lymphoma: A Case Report.

Medicine (Baltimore) 2016 Mar;95(11):e3131

From the Divisions of Pulmonary Medicine (TA, MI, HN, ST, TB) and Hematology (TK, TS, SO), Department of Medicine; Division of Diagnostic Pathology (KK); and Center for Infectious Diseases and Infection Control (KS, NH), Keio University School of Medicine; Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases (NN, YH), Tokyo, Japan.

Mycobacterium marinum is a ubiquitous waterborne organism that mainly causes skin infection in immunocompetent patients, and its disseminated infection is rare. Extranodal NK/T cell lymphoma, nasal type (ENKL) usually localizes at the nasal and/or paranasal area, but occasionally disseminates into the skin/soft tissue and gastrointestinal tract. Compromised immunity is a risk factor for developing nontuberculous mycobacterial (NTM) infection and malignant lymphoma, and the 2 diseases may share similar clinical presentation; however, only a few reports have described NTM infection mimicking malignant lymphoma. Read More

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March 2016
23 Reads

Heterogeneity in the genetic alterations and in the clinical presentation of acrodermatitis enteropathic: Case report and review of the literature.

Int J Immunopathol Pharmacol 2016 Jun 18;29(2):274-9. Epub 2015 Dec 18.

Dermatology Unit - Department of Specialistic, Diagnostic and Experimental Medicine, S. Orsola- Malpighi Hospital, Italy.

Acrodermatitis enteropathic (AE) is a rare autosomal recessive disorder due to a zinc deficiency and characterized by a classical triad of symptoms: dermatitis, alopecia, and diarrhea. The defective gene is SLC39A4, which encodes a zinc transporter. Nevertheless many abnormalities in SLC39A4 have been relieved, only 50% of patients show alterations. Read More

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June 2016
1 Read

Skeletal indicators of reactive arthritis: A case study comparison to other skeletal conditions, such as rheumatoid arthritis, ankylosing spondylitis, ankylosing sero-negative SpA, and DISH.

Int J Paleopathol 2015 Dec 17;11:70-74. Epub 2015 Nov 17.

Department of Sociology, Anthropology and Social Work, MS 1012, Texas Tech University, Lubbock, TX 79409, United States.

In this case study we report a unique modern case of severe reactive arthritis (Reiter's Syndrome) observed on an elderly Cypriot female from the St. Nicholas cemetery in Limassol, Cyprus and the successful differential diagnosis of the condition. The individual exhibited lesions specific to fusion of the thoracic and lumbar spinal column, primarily along the posterior aspect of the spine with sacroiliac fusion, fusion of the left femoral head within the acetabulum, no intervertebral fusion, and severe Launois's deformity with no corresponding fusion or arthritis mutilans of the hands. Read More

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December 2015
4 Reads

Impact of a multidisciplinary approach in enteropathic spondyloarthritis patients.

Autoimmun Rev 2016 Feb 7;15(2):184-90. Epub 2015 Nov 7.

GI Unit, Dpt. Department of Systems Medicine, University Tor Vergata, Rome, Italy.

Spondyloarthritis (SpA) and inflammatory bowel disease (IBD) are chronic autoinflammatory diseases that partially share the genetic predisposition and the unchecked inflammatory response linking the gut to the joints. The coexistence of both conditions in patients and the increased cross-risk ratios between SpA and IBD strongly suggest a shared pathophysiology. The prevalence of Enteropathic-related Spondyloarthritis (ESpA) in IBD patients shows a wide variation and may be underestimated. Read More

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February 2016
12 Reads

Costs of Absenteeism In Psoriatic and Enteropathic Arthropathies Based on Real-Life Data From Poland's Social Insurance Institution Database In 2013.

Value Health 2015 Nov 20;18(7):A665. Epub 2015 Oct 20.

Jagiellonian University Medical Collage Institute of Public Health, Krakow, Poland.

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November 2015
4 Reads

Genetics of ankylosing spondylitis--insights into pathogenesis.

Nat Rev Rheumatol 2016 Feb 6;12(2):81-91. Epub 2015 Oct 6.

NIHR Oxford Musculoskeletal Biomedical Research Unit and Comprehensive Biomedical Research Centre, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK.

Ankylosing spondylitis (AS), an immune-mediated arthritis, is the prototypic member of a group of conditions known as spondyloarthropathies that also includes reactive arthritis, psoriatic arthritis and enteropathic arthritis. Patients with these conditions share a clinical predisposition for spinal and pelvic joint dysfunction, as well as genetic associations, notably with HLA-B(*)27. Spondyloarthropathies are characterized by histopathological inflammation in entheses (regions of high mechanical stress where tendons and ligaments insert into bone) and in the subchondral bone marrow, and by abnormal osteoproliferation at involved sites. Read More

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February 2016
5 Reads

Nutritional Impact of Dietary Plasma Proteins in Animals Undergoing Experimental Challenge and Implications for Patients with Inflammatory Bowel Disorders: A Meta-analysis.

Adv Nutr 2015 Sep 15;6(5):541-51. Epub 2015 Sep 15.

Entera Health, Inc., Cary, NC; and.

Studies administering plasma protein isolates (PPIs) to experimentally challenged animals have reported improvements in growth, food intake, and overall condition when compared with animals fed control diets, due in part to improvements in gut barrier function, normalization of cytokine signals, and support of enteric immune function. These and early clinical studies suggest that nutritional therapy with PPIs may similarly assist in restoring homeostasis to gut barrier function in humans experiencing mild or more acute enteropathic symptomatology such as irritable bowel syndrome and inflammatory bowel disease. This meta-analysis evaluated the ability of PPIs to promote weight gain and food intake in weanling animals, primarily piglets, after oral challenge with various enteric pathogens or bacterial toxins. Read More

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September 2015
6 Reads

Seronegative reactive spondyloarthritis and the skin.

Clin Dermatol 2015 Sep-Oct;33(5):531-7. Epub 2015 May 27.

Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano, Milan, Italy; BIOMETRA Department, University of Milan, Milan, Italy. Electronic address:

Spondyloarthritidies represent a group of conditions affecting the axial and peripheral muscoloskeletal apparatus and are often associated with psoriasis, infections, and inflammatory bowel diseases. Other diseases included in this category are psoriatic arthritis, ankylosing spondylitis, and enteropathic arthritis. Reactive arthritis is an elusive spondyloarthritis, commonly occurring 1 to 3 weeks after a digestive or a genitourinary tract infection, in which microorganisms do not infect the joint directly. Read More

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June 2016
6 Reads

Efficacy of subcutaneous immunoglobulins in primary immunodeficiency with Crohn's-like phenotype: report of a case.

Eur Rev Med Pharmacol Sci 2015 ;19(14):2641-5

Department of Clinical Medicine and Surgery, University of Naples Federico II, School of Medicine, Naples, Italy.

Common variable immune deficiency (CVID) is the most frequent primary immunodeficiency in adults. In CVID, the prevalence of gastrointestinal manifestations ranges between 2 and 50% with a complication-related morbidity second only to that of the respiratory tract. In some cases, clinical and endoscopic features are undistinguishable from those of inflammatory bowel disease (IBD). Read More

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February 2016
1 Read

"Toothbrush" the Feet: A Periodic Mechanical Stimulus for Healing of a Severe Chronic Leg Ulcer.

Int J Low Extrem Wounds 2015 Sep 5;14(3):291-4. Epub 2015 Apr 5.

424 General Military Hospital, Thessaloniki, Greece.

Chronic wounds develop when the sequence of healing events are disrupted, usually in patients with underlying diseases such as diabetes mellitus, venous insufficiency, peripheral artery disease, and neuropathies and they affect most often the lower extremities. We present a 68-year-old woman with plantar ulceration, lasting for approximately 18 months, resistant to healing with conventional therapy and various modalities we used. The patient had a long history of seronegative enteropathic arthritis, Crohn's disease, secondary fibrillar amyloidosis, multiplex neuropathy, and small vessel vasculitis, the latter being the trigger event for the ulceration of her right foot. Read More

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September 2015

Management of arthropathy in inflammatory bowel diseases.

Ther Adv Chronic Dis 2015 Mar;6(2):65-77

Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.

The most common extra-intestinal manifestation in patients with inflammatory bowel disease (IBD) is articular involvement, with a prevalence ranging between 17% and 39%. It is frequently characterized by an involvement of the axial joints but may also be associated with peripheral arthritis. The target of therapy in the management of arthritis associated with IBD is to reduce the inflammation and prevent any disability and/or deformity. Read More

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March 2015
4 Reads

Two-year incidence of psoriasis, uveitis and inflammatory bowel disease in patients with spondyloarthritis: A study in the AQUILES cohort.

Reumatol Clin 2016 Jan-Feb;12(1):22-6. Epub 2015 Feb 13.

Departamento de Medical Affairs, Merck Sharp & Dohme de España, S. A., Madrid, España.

Objectives: To describe the 2-year incidence of new extra-articular manifestations (uveitis, psoriasis, inflammatory bowel disease) in a cohort of patients with spondyloarthritis included in the AQUILES study.

Patients: Over a period of 2 years, 513 patients with spondyloarthritis (62.5% males, mean age 48 years) diagnosed with ankylosing spondylitis (AS) (55. Read More

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February 2017
7 Reads

Spondyloarthritis and the microbiome: new insights from an ancient hypothesis.

Curr Rheumatol Rep 2015 Feb;17(2):10

Division of Rheumatology, Department of Medicine, New York University School Medicine, New York, NY, USA.

The human microbiome, which represents the total collection of microorganisms (and their genes) inhabiting the human body, has increasingly been recognized as a potential key factor in the development of autoimmune disease. Multiple studies suggest that the microbiome has significant influence on immune homeostasis, while disruptions in local microbiome composition can result in a heightened systemic inflammatory response. The intestinal microbiome, in particular, harbors the densest assembly of bacteria and appears to influence the immune system in the context of inflammatory arthropathies. Read More

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February 2015
4 Reads

Modulatory activity of Lactobacillus rhamnosus OLL2838 in a mouse model of intestinal immunopathology.

Immunobiology 2015 Jun 19;220(6):701-10. Epub 2015 Jan 19.

Institute of Food Sciences, National Research Council, Avellino, Italy. Electronic address:

Gut microbiota and probiotic strains play an important role in oral tolerance by modulating regulatory and effector cell components of the immune system. We have previously described the ability of Lactobacilli to influence both the innate and adaptive immunity to wheat gluten, a food antigen, in mouse. In this study, we further explored the immunomodulatory mechanisms elicited in this model by testing three specific probiotic strains, namely L. Read More

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June 2015
11 Reads

Celiac disease: a disorder emerging from antiquity, its evolving classification and risk, and potential new treatment paradigms.

Authors:
Hugh J Freeman

Gut Liver 2015 Jan;9(1):28-37

Department of Medicine, University of British Columbia, Vancouver, Canada.

Celiac disease is a chronic genetically based gluten-sensitive immune-mediated enteropathic process primarily affecting the small intestinal mucosa. The disorder classically presents with diarrhea and weight loss; however, more recently, it has been characterized by subclinical occult or latent disease associated with few or no intestinal symptoms. Diagnosis depends on the detection of typical histopathological biopsy changes followed by a gluten-free diet response. Read More

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January 2015

Extra-articular disease in patients with spondyloarthritis. Baseline characteristics of the spondyloarthritis cohort of the AQUILES study.

Reumatol Clin 2015 Mar-Apr;11(2):83-9. Epub 2014 Nov 11.

Hospital Gregorio Marañón, Madrid, España.

Objectives: To describe the prevalence of extra-articular disease (uveitis, psoriasis and inflammatory bowel disease [IBD]), in a cohort of patients with spondyloarthritis (SpA).

Patients And Methods: AQUILES is an observational, prospective and multicentric study of three cohorts of patients with one of the following immune-mediated inflammatory diseases (IMID): SpA, psoriasis, or IBD. In the present cohort, patients ≥18 years of age with SpA were enrolled from Rheumatology clinics. Read More

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December 2016
51 Reads

Leclercia adecarboxylata Bacteremia in a Patient with Ulcerative Colitis.

Case Rep Gastrointest Med 2014 28;2014:457687. Epub 2014 Oct 28.

Department of Medicine, Riverside County Regional Medical Center, 26520 Cactus Avenue Moreno Valley, CA 92555, USA.

Patients with inflammatory bowel disease (IBD) are a high risk population for bacteremia. Derangement in the mucosal architecture of the gastrointestinal (GI) tract and frequent endoscopic interventions in immunocompromised individuals are considered primary causes. Isolation of opportunistic microorganisms from the bloodstream of IBD patients has been increasingly reported in recent years. Read More

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November 2014
35 Reads

SLC39A4 mutation in zinc deficiency patients.

J Med Assoc Thai 2014 Jun;97 Suppl 6:S14-9

Objective: To analyze the clinical presentation and SLC39A4 mutations in zinc deficiency patients.

Material And Method: The authors conducted a cross-sectional study on all cases of zinc deficiency treated at Queen Sirikit National Institute of Child Health between January 2004 and December 2012. Demographic data, clinical manifestations, laboratory results, treatment and outcome were analyzed. Read More

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June 2014
37 Reads

Novel clathrin activity: developments in health and disease.

Authors:
Joel A Ybe

Biomol Concepts 2014 May;5(2):175-82

Clathrin self-assembles into a coat around vesicles filled with cargo such as nutrients, hormones, and proteins destined for degradation. Recent developments indicate clathrin is not a specialist, but is involved in different processes relevant to health and disease. Clathrin is used to strengthen centrosomes and mitotic spindles essential for chromosome segregation in cell division. Read More

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Costs of Absenteeism In Psoriatic and Enteropathic Arthropathies Based On Real-Life Data From Poland's Social Insurance Institution Database In 2012.

Value Health 2014 Nov 26;17(7):A528. Epub 2014 Oct 26.

Jagiellonian University Medical College, Krakow, Poland.

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November 2014
4 Reads

Mesalamine-induced refractory fever and progressive increase in creatinine level and leukocyte count in a patient with enteropathic arthritis.

Authors:
Metin Işık

Eur J Rheumatol 2014 Sep 1;1(3):129-130. Epub 2014 Sep 1.

Department of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

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September 2014
1 Read

Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling.

Schizophr Res 2016 09 15;176(1):23-35. Epub 2014 Jul 15.

Department of Mental Health, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA.

Autoimmunity, gastrointestinal (GI) disorders and schizophrenia have been associated with one another for a long time. This paper reviews these connections and provides a context by which multiple risk factors for schizophrenia may be related. Epidemiological studies strongly link schizophrenia with autoimmune disorders including enteropathic celiac disease. Read More

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September 2016
7 Reads

Gliadin intake alters the small intestinal mucosa in indomethacin-treated HLA-DQ8 transgenic mice.

Am J Physiol Gastrointest Liver Physiol 2014 Aug 12;307(3):G302-12. Epub 2014 Jun 12.

Institute of Food Sciences, National Research Council, Avellino, Italy;

Celiac disease (CD) is an enteropathy caused by the ingestion of wheat gluten in genetically susceptible individuals. A complete understanding of the pathogenic mechanisms in CD has been hindered because of the lack of adequate in vivo models. In the present study, we explored the events after the intragastric administration of gliadin and of the albumin/globulin fraction from wheat in human leukocyte antigen-DQ8 transgenic mice (DQ8 mice) treated with indomethacin, an inhibitor of cyclooxygenases (COXs). Read More

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August 2014
2 Reads