140 results match your criteria Enteropathic Arthropathies


Microplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis.

Sci Total Environ 2022 Feb 7;809:152212. Epub 2021 Dec 7.

Immunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia; Australian Infectious Disease Research Centre, GVN Center of Excellence, Brisbane, Queensland 4029 and 4072, Australia. Electronic address:

Global microplastic (MP) contamination and the effects on the environment are well described. However, the potential for MP consumption to affect human health remains controversial. Mice consuming ≈80 μg/kg/day of 1 μm polystyrene MPs via their drinking water showed no weight loss, nor were MPs detected in internal organs. Read More

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February 2022

Enteropathic Arthritis Beyond the Criteria.

Inflamm Bowel Dis 2022 03;28(4):e51-e52

Department of Rheumatology, Trakya University Medical School, Edirne, Turkey.

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Intestinal microbiota changes induced by TNF-inhibitors in IBD-related spondyloarthritis.

RMD Open 2021 09;7(3)

Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.

Background: The close relationship between joints and gut inflammation has long been known and several data suggest that dysbiosis could link spondyloarthritis (SpA) to inflammatory bowel diseases (IBD). The introduction of biological drugs, in particular tumour necrosis factor inhibitors (TNFi), revolutionised the management of both these diseases. While the impact of conventional drugs on gut microbiota is well known, poor data are available about TNFi. Read More

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September 2021

Uveitis-related Factors in Patients With Spondyloarthritis: TReasure Real-Life Results.

Am J Ophthalmol 2021 08 4;228:58-64. Epub 2021 Apr 4.

From the Division of Rheumatology, Department of Internal Medicine, Eskisehir Osmangazi University, Eskisehir.

Purpose: Spondyloarthritis (SpA) is a group of diseases with overlapping skeletal and extra-articular features. Acute anterior uveitis (AAU) is the most common extra-articular manifestation of SpA. The relation between AAU and SpA is well defined in the current literature. Read More

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Do patients with rheumatoid arthritis show a different course of COVID-19 compared to patients with spondyloarthritis?

Clin Exp Rheumatol 2021 May-Jun;39(3):639-647. Epub 2021 Mar 30.

Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus Liebig University Giessen, Bad Nauheim, Germany.

Objectives: Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are the most common inflammatory rheumatic diseases (IRD). The aim of this study was to elucidate differences in the outcome of SARS-CoV-2 infection in RA- and SpA-patients.

Methods: Data from the German COVID-19 registry for IRD patients from 30th March to 16th November 2020 were analysed. Read More

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Inhibition of Phosphodiesterase-4 in Psoriatic Arthritis and Inflammatory Bowel Diseases.

Int J Mol Sci 2021 Mar 5;22(5). Epub 2021 Mar 5.

Department of Clinical and Molecular Medicine, S. Andrea University Hospital, "Sapienza" University, 00189 Rome, Italy.

Phosphodiesterases (PDEs) are a heterogeneous superfamily of enzymes which catalyze the degradation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Among PDEs, PDE4 is the most widely studied and characterized isoenzyme. PDE4 blocking can lead to increased levels of intracellular cAMP, which results in down-regulation of inflammatory responses by reducing the expression of tumor necrosis factor (TNF), interleukin (IL)-23, IL-17, interferon-γ, while increasing regulatory cytokines, such as IL-10. Read More

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Two years follow-up of golimumab treatment in refractory enteropathic spondyloarthritis patients with Crohn disease: A STROBE-compliant study.

Medicine (Baltimore) 2021 Mar;100(12):e25122

Rheumatology, Allergology and Clinical Immunology.

Abstract: Golimumab is a fully human monoclonal antibody against tumor necrosis factor (TNF) approved for the treatment of ulcerative colitis and not for Crohn disease (CD). Many CD patients experience primary, secondary failure, or intolerance to other TNF inhibitors (TNFi) approved in Italy for CD (adalimumab and infliximab). Spondyloarthritis (SpA) may be associated with CD (enteropathic, ESpA) in up to 50% of patients requiring a multidisciplinary and tailored approach. Read More

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Is the impact of biologic agents in enteropathic spondylitis different from other spondylitis? Real life data from the HUR-BIO Registry.

Clin Exp Rheumatol 2022 01 25;40(1):112-119. Epub 2021 Feb 25.

Division of Rheumatology, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Objectives: To compare enteropathic spondylitis (ES) with psoriatic spondylitis (PS) and ankylosing spondylitis (AS), in patients on biological disease-modifying anti-rheumatic drug (bDMARD) treatment.

Methods: Patients who were enrolled in the HUR-BIO registry were included. ES patients were considered as the main study group; AS and PS patients were included as the control groups. Read More

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January 2022

ANCA-associated vasculitis in a patient with enteropathic spondylarthritis: a case report and literature review.

Clin Rheumatol 2021 Aug 30;40(8):3351-3355. Epub 2021 Jan 30.

Rheumatology Department, Unidade Local de Saúde do Alto Minho, Largo Conde Bertiandos, 4990-041, Ponte de Lima, Portugal.

Coexistence of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and inflammatory bowel disease (IBD) is rare (Sy et al. in Semin Arthritis Rheum 45:475-482, 2016). Nevertheless, we present a case of an AAV in a 53-year-old female with enteropathic spondylarthritis previously treated with tumor necrosis factor α inhibitors (TNFi). Read More

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The Delay of Diagnosis in Spondyloarthropathy Patients in a Tertiary Hospital in Saudi Arabia.

Cureus 2021 Jan 11;13(1):e12629. Epub 2021 Jan 11.

Department of Internal Medicine, King Saud University College of Medicine, Riyadh, SAU.

Objective Seronegative spondyloarthropathies (SpA) are a group of rheumatological disorders that share the common feature of being rheumatoid factor negative. Inflammation of the sacroiliac joint is considered the hallmark of ankylosing spondylitis (AS). On the other hand, psoriatic arthritis (PsA) affects patients with psoriasis. Read More

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January 2021

A case of enteropathic arthritis complicated by superimposed bilateral septic arthritis of the hips.

Mod Rheumatol Case Rep 2021 07 18;5(2):387-390. Epub 2021 Jan 18.

Department of Rheumatology, West Middlesex Hospital, London, UK.

Polyarticular septic arthritis is an underappreciated clinical entity. Pre-existing joint diseases, such as osteoarthritis and rheumatoid arthritis have been shown to be risk factors for septic arthritis. However, there is a paucity of data in the literature regarding the risk of septic arthritis in those patients with enteropathic arthritis. Read More

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Elucidating potential molecular signatures through host-microbe interactions for reactive arthritis and inflammatory bowel disease using combinatorial approach.

Sci Rep 2020 09 15;10(1):15131. Epub 2020 Sep 15.

Fortis Hospital, B-22, Sector 62, Gautam Buddh Nagar, Noida, Uttar Pradesh, 201301, India.

Reactive Arthritis (ReA), a rare seronegative inflammatory arthritis, lacks exquisite classification under rheumatic autoimmunity. ReA is solely established using differential clinical diagnosis of the patient cohorts, where pathogenic triggers linked to enteric and urogenital microorganisms e.g. Read More

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September 2020

Incidence of spondyloarthritis and its subtypes: a systematic review.

Clin Exp Rheumatol 2021 May-Jun;39(3):660-667. Epub 2020 Sep 4.

Division of Rheumatology, University of Ioannina Medical School, Greece.

Objectives: Several epidemiologic studies of spondylarthritis (SpA) and its subtypes have been reported during the last decades. The majority of these studies provided prevalence estimates and showed a considerable variation in the reported frequency of SpA subtypes. Most systematic reviews published in this field aimed to summarise the results of prevalence studies, however, incidence studies are important for an accurate picture of a disease occurrence in a defined population. Read More

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Observational study on the evaluation of quality of life in patients affected by enteropathic spondyloarthritis.

Musculoskeletal Care 2020 12 20;18(4):527-534. Epub 2020 Aug 20.

Rheumatology Unit, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Background: Enteropathic spondyloarthritis (ESpA) and inflammatory bowel diseases (IBD) have high impact on physical and psychological health but health-related quality of life (HRQoL) has never been evaluated in ESpA patients.

Purpose: Cross-sectional multidisciplinary study was performed to evaluate HRQoL, state of health, and well-being in IBD and ESpA patients.

Methods: Consecutive IBD and ESpA outpatients were enrolled. Read More

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December 2020

Increased risk of cervical dysplasia in females with autoimmune conditions-Results from an Australia database linkage study.

PLoS One 2020 18;15(6):e0234813. Epub 2020 Jun 18.

Department of Neurology, MS and Neuroimmunology Service, Alfred Health, Melbourne, Australia.

Background: Autoimmune conditions (AICs) and/or their treatment may alter risk of human papilloma virus (HPV) infection and females with AICs are therefore at an increased risk of cervical dysplasia. However, inclusion of these at-risk populations in cervical cancer screening and HPV-vaccination guidelines, are mostly lacking. This study aimed to determine the prevalence of cervical dysplasia in a wide range of AICs and compare that to HIV and immunocompetent controls to support the optimisation of cervical cancer preventive health measures. Read More

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Innate lymphoid cells in inflammatory arthritis.

Arthritis Res Ther 2020 02 12;22(1):25. Epub 2020 Feb 12.

Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Lujiang Str 17, Hefei, 230001, China.

Aberrant activation and dysregulation of immune system is a common feature of many forms of inflammatory arthritis. Since their identification as a distinctive population of leukocytes, innate lymphoid cells (ILCs) have been considered crucial in maintaining tissue homeostasis and bridges between innate and adaptive immune system. Altered ILCs' subset distribution and function have been observed in a variety of autoimmune and chronic inflammatory diseases and suggest a subset-specific role of ILCs in the pathogenesis of immune-mediated inflammation. Read More

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February 2020

Enteropathic spondyloarthritis: Results from a large nationwide database analysis.

Autoimmun Rev 2020 Feb 12;19(2):102457. Epub 2019 Dec 12.

Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.

Introduction: Spondyloarthrits (SpA) share clinical, genetic and immunological features with Inflammatory Bowel Diseases (IBD), and enteropathic SpA (eSpA) represent the clinical evidence of the association between gut and joint diseases. This cross-sectional study aimed to report data of eSpA patients collected from the first Italian database.

Patients And Methods: A specific web-based interface has been created to insert and collect the main clinical, serologic and imaging data from patients with eSpA, as well as disease activity, comorbidities and treatment, in a real-life scenario. Read More

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February 2020

Integrated gastroenterology and rheumatology ambulatory: an innovative approach for enteropathic spondyloarthritis early diagnosis.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):246-248

Medicina Interna, Gastroenterologia e Reumatologia, Ospedale Nuovo Regina Margherita, Rome, Italy.

Patients with inflammatory bowel disease (IBD) may develop rheumatic diseases, particularly enterophatic spondyloarthritis (ESpA). Similarly, an IBD may develop in patients with SpA. Management of these patients in a dedicated ambulatory could be advantageous. Read More

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February 2020

Mud-bath treatment of seronegative spondyloarthritis: experience at the Euganean Thermal Area.

Int J Biometeorol 2020 Jun 24;64(6):937-941. Epub 2019 Jul 24.

Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy.

Mud-bath therapy (MBT) has been used as a treatment for rheumatic diseases and musculoskeletal complaints in the Euganean Thermal Area (near Padova, Italy) since ancient time. There is no consensus about the use of MBT in patients with inflammatory rheumatic diseases, although experimental studies have suggested a beneficial effect of MBT on chronic articular inflammation. To evaluate the effects of MBT in patients affected by seronegative spondyloarthritis, very common chronic inflammatory rheumatic diseases, randomized controlled trials (RCT) performed in the Euganean Thermal Area have been reviewed. Read More

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Use of synthetic and biological DMARDs in patients with enteropathic spondyloarthritis: a combined gastro-rheumatological approach.

Clin Exp Rheumatol 2019 Sep-Oct;37(5):723-730. Epub 2019 Jun 6.

Department of Systems Medicine, Rheumatology, Allergology and Clinical Immunology, University of Rome 'Tor Vergata', Rome, Italy.

Objectives: The aim of this 2-year prospective study was to assess the diagnostic and therapeutic effect of a combined gastro-rheumatological approach in enteropathic spondyloarthritis (eSpA) patients.

Methods: Inflammatory bowel disease (IBD) patients with joint pain were referred by IBD-dedicated gastroenterologists to a dedicated rheumatologist. At baseline and at 3, 6, 12, 24 months, the following parameters were recorded: clinical and biochemical variables, SpA and IBD activity scores, treatment (conventional synthetic; csDMARDs, biologics; bDMARDs). Read More

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October 2019

Evaluation of the safety and satisfaction of rheumatic patients with accelerated infliximab infusion.

Adv Rheumatol 2018 08 3;58(1):22. Epub 2018 Aug 3.

SOS Vida, Rheumatology Unit, Salvador, Bahia, Brazil.

Introduction: Infliximab infusion generally occurs in 2-4 h. Recent studies have suggested the possibility of accelerated infusion (1 h) of this drug.

Objective: To evaluate the safety of accelerated infliximab infusion in patients with rheumatic diseases. Read More

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Classifications and imaging of juvenile spondyloarthritis.

J Ultrason 2018 ;18(74):224-233

University of Nis, Faculty of Medicine, Department of Pediatric Rheumatology and Immunology, Serbia.

Juvenile spondyloarthritis may be present in at least 3 subtypes of juvenile idiopathic arthritis according to the classification of the International League of Associations for Rheumatology. By contrast with spondyloarthritis in adults, juvenile spondyloarthritis starts with inflammation of peripheral joints and entheses in the majority of children, whereas sacroiliitis and spondylitis may develop many years after the disease onset. Peripheral joint involvement makes it difficult to differentiate juvenile spondyloarthritis from other juvenile idiopathic arthritis subtypes. Read More

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January 2018

Spondyloarthropathy in vertebrae of the aquatic Cretaceous snake Lunaophis aquaticus, and its first recognition in modern snakes.

Naturwissenschaften 2018 Aug 14;105(9-10):51. Epub 2018 Aug 14.

Oxford University Museum of Natural History, Oxford, UK.

Inflammatory arthritis is documented for the first time in snakes. Ossification of the intervertebral capsule and zygapophyseal joints resulting in segmental vertebral fusion was observed in the aquatic Cretaceous snake Lunaophis aquaticus. Such pathologic alterations are pathognomonic for the spondyloarthropathy form of inflammatory arthritis. Read More

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Ocular features of the HLA-B27-positive seronegative spondyloarthropathies.

Curr Opin Ophthalmol 2018 Nov;29(6):552-557

Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin Eye Institute, Milwaukee, Wisconsin, USA.

Purpose Of Review: The seronegative spondyloarthropathies are a closely related group of inflammatory diseases that include ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthritis, inflammatory bowel disease and undifferentiated spondyloarthritis. This review focuses on the spectrum of ocular manifestations associated with these diseases and the current approaches in treating these ocular manifestations. It also highlights the role ophthalmologists can play in identifying and appropriately treating human leukocyte antigen B27 (HLA-B27) associated uveitis and the associated spondyloarthropathies in order to limit ocular and systemic morbidity. Read More

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November 2018

IL-17 in the immunopathogenesis of spondyloarthritis.

Nat Rev Rheumatol 2018 08;14(8):453-466

Department of Rheumatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Spondyloarthritis (SpA) is a term that refers to a group of inflammatory diseases that includes psoriatic arthritis, axial SpA and nonradiographic axial SpA, reactive arthritis, enteropathic arthritis and undifferentiated SpA. The disease subtypes share clinical and immunological features, including joint inflammation (peripheral and axial skeleton); skin, gut and eye manifestations; and the absence of diagnostic autoantibodies (seronegative). The diseases also share genetic factors. Read More

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Nature versus nurture in the spectrum of rheumatic diseases: Classification of spondyloarthritis as autoimmune or autoinflammatory.

Autoimmun Rev 2018 Sep 11;17(9):935-941. Epub 2018 Jul 11.

Cellular Diagnostics & Cell Therapy, Central Diagnostic Laboratory, Maastricht University Medical Centre, Maastricht, the Netherlands. Electronic address:

Spondyloarthritides (SpA) include inflammatory joint diseases with various clinical phenotypes that may also include the axial skeleton and/or entheses. SpA include psoriatic arthritis, reactive arthritis, enteropathic arthritis and ankylosing spondylitis; the latter is frequently associated with extra-articular manifestations, such as uveitis, psoriasis, and inflammatory bowel disease. SpA are associated with the HLA-B27 allele and recognize T cells as key pathogenetic players. Read More

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September 2018

The Seronegative Spondyloarthropathies.

Prim Care 2018 Jun;45(2):271-287

Department of Rheumatology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA. Electronic address:

The seronegative spondyloarthropathies are a group of five diseases characterized by inflammatory oligoarticular arthritis, enthesitis, and axial involvement. They have an increased incidence of the HLA-B27 gene. They are commonly associated with extra-articular features including involvement of the skin, eyes, and gastrointestinal tract. Read More

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An unexpected cause of sacroiliitis in a patient with gout and chronic psoriasis with inflammatory arthritis: a case report.

BMC Musculoskelet Disord 2018 Apr 20;19(1):126. Epub 2018 Apr 20.

Rheumatology Department, Cork University Hospital, Cork, Ireland.

Background: Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis and reactive arthritis. Inflammatory back pain can be caused by many other conditions like infection and crystal deposition such as gout. Read More

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Anti-alpha-enolase antibodies in Behçet's disease: a marker of mucocutaneous and articular disease activity?

Clin Exp Rheumatol 2018 Nov-Dec;36(6 Suppl 115):28-32. Epub 2018 Feb 7.

Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Brazil.

Objectives: To assess IgM anti-alpha-enolase antibodies (AAEA) in systemic Behçet's disease (BD) and its possible association with clinical manifestations and disease activity.

Methods: Ninety-seven consecutively selected BD patients were compared to 36 enteropathic spondyloarthritis (ESpA) [24 Crohn's disease (CD) and 12 ulcerative colitis (UC)] patients and 87 healthy controls. IgM AAEA was detected by immunoblotting. Read More

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