117 results match your criteria Enteropathic Arthropathies


Classifications and imaging of juvenile spondyloarthritis.

J Ultrason 2018 ;18(74):224-233

University of Nis, Faculty of Medicine, Department of Pediatric Rheumatology and Immunology, Serbia.

Juvenile spondyloarthritis may be present in at least 3 subtypes of juvenile idiopathic arthritis according to the classification of the International League of Associations for Rheumatology. By contrast with spondyloarthritis in adults, juvenile spondyloarthritis starts with inflammation of peripheral joints and entheses in the majority of children, whereas sacroiliitis and spondylitis may develop many years after the disease onset. Peripheral joint involvement makes it difficult to differentiate juvenile spondyloarthritis from other juvenile idiopathic arthritis subtypes. Read More

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http://jultrason.pl/index.php/issues/volume-18-no-74/classif
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http://dx.doi.org/10.15557/JoU.2018.0033DOI Listing
January 2018
17 Reads

Spondyloarthropathy in vertebrae of the aquatic Cretaceous snake Lunaophis aquaticus, and its first recognition in modern snakes.

Naturwissenschaften 2018 Aug 14;105(9-10):51. Epub 2018 Aug 14.

Oxford University Museum of Natural History, Oxford, UK.

Inflammatory arthritis is documented for the first time in snakes. Ossification of the intervertebral capsule and zygapophyseal joints resulting in segmental vertebral fusion was observed in the aquatic Cretaceous snake Lunaophis aquaticus. Such pathologic alterations are pathognomonic for the spondyloarthropathy form of inflammatory arthritis. Read More

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http://link.springer.com/10.1007/s00114-018-1576-7
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http://dx.doi.org/10.1007/s00114-018-1576-7DOI Listing
August 2018
5 Reads

Ocular features of the HLA-B27-positive seronegative spondyloarthropathies.

Curr Opin Ophthalmol 2018 Nov;29(6):552-557

Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin Eye Institute, Milwaukee, Wisconsin, USA.

Purpose Of Review: The seronegative spondyloarthropathies are a closely related group of inflammatory diseases that include ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthritis, inflammatory bowel disease and undifferentiated spondyloarthritis. This review focuses on the spectrum of ocular manifestations associated with these diseases and the current approaches in treating these ocular manifestations. It also highlights the role ophthalmologists can play in identifying and appropriately treating human leukocyte antigen B27 (HLA-B27) associated uveitis and the associated spondyloarthropathies in order to limit ocular and systemic morbidity. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000525DOI Listing
November 2018
14 Reads

IL-17 in the immunopathogenesis of spondyloarthritis.

Nat Rev Rheumatol 2018 Aug;14(8):453-466

Department of Rheumatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Spondyloarthritis (SpA) is a term that refers to a group of inflammatory diseases that includes psoriatic arthritis, axial SpA and nonradiographic axial SpA, reactive arthritis, enteropathic arthritis and undifferentiated SpA. The disease subtypes share clinical and immunological features, including joint inflammation (peripheral and axial skeleton); skin, gut and eye manifestations; and the absence of diagnostic autoantibodies (seronegative). The diseases also share genetic factors. Read More

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http://dx.doi.org/10.1038/s41584-018-0044-2DOI Listing
August 2018
11 Reads

Nature versus nurture in the spectrum of rheumatic diseases: Classification of spondyloarthritis as autoimmune or autoinflammatory.

Autoimmun Rev 2018 Sep 11;17(9):935-941. Epub 2018 Jul 11.

Cellular Diagnostics & Cell Therapy, Central Diagnostic Laboratory, Maastricht University Medical Centre, Maastricht, the Netherlands. Electronic address:

Spondyloarthritides (SpA) include inflammatory joint diseases with various clinical phenotypes that may also include the axial skeleton and/or entheses. SpA include psoriatic arthritis, reactive arthritis, enteropathic arthritis and ankylosing spondylitis; the latter is frequently associated with extra-articular manifestations, such as uveitis, psoriasis, and inflammatory bowel disease. SpA are associated with the HLA-B27 allele and recognize T cells as key pathogenetic players. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.04.002DOI Listing
September 2018
15 Reads
7.933 Impact Factor

The Seronegative Spondyloarthropathies.

Prim Care 2018 Jun;45(2):271-287

Department of Rheumatology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA. Electronic address:

The seronegative spondyloarthropathies are a group of five diseases characterized by inflammatory oligoarticular arthritis, enthesitis, and axial involvement. They have an increased incidence of the HLA-B27 gene. They are commonly associated with extra-articular features including involvement of the skin, eyes, and gastrointestinal tract. Read More

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http://dx.doi.org/10.1016/j.pop.2018.02.005DOI Listing
June 2018
9 Reads

One year in review 2017: spondyloarthritis.

Clin Exp Rheumatol 2018 Jan-Feb;36(1):1-14. Epub 2018 Feb 5.

GenOMeC PhD, University of Siena; and Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.

The term spondyloarthritis (SpA) represents a condition characterised by a broad spectrum of clinical manifestations, laboratory abnormalities and imaging features; in particular, SpA is an inflammatory condition in which both peripheral and axial joints might be affected. The majority of people with this disease have either psoriatic arthritis or axial spondyloarthritis, which includes ankylosing spondylitis. Less common subgroups are enteropathic SpA, which is associated with inflammatory bowel diseases (Crohn's disease and ulcerative colitis), reactive arthritis, which can occur in people following gastrointestinal or genitourinary infections and undifferentiated SpA, that does not meet the diagnostic criteria of the other subgroups at onset, but that may evolve to do so later. Read More

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April 2018
30 Reads

Spondyloarthritis features in zymosan-induced SKG mice.

Joint Bone Spine 2018 Oct 29;85(5):583-591. Epub 2017 Nov 29.

Division of Rheumatology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea. Electronic address:

Objectives: Spondyloarthritis (SpA) encompasses a group of disorders including ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and enteropathic arthritis. SpA pathogenesis is still not well understood. Animal models are important for studying disease mechanisms and identifying new therapeutic agents. Read More

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http://dx.doi.org/10.1016/j.jbspin.2017.11.008DOI Listing
October 2018
6 Reads

Adalimumab efficacy in enteropathic spondyloarthritis: A 12-mo observational multidisciplinary study.

World J Gastroenterol 2017 Oct;23(39):7139-7149

Dipartimento Scienze Cliniche e Molecolari, Clinica Medica, Università Politecnica delle Marche, Ancona 60126, Italy.

Aim: To report adalimumab (Ada) efficacy on articular-gastrointestinal disease and health-related quality of life (HRQoL) in patients with enteropathic spondyloarthritis (ES).

Methods: A cohort of 52 patients with ES was evaluated in the departments of gastroenterology and internal medicine. At baseline, all patients underwent assessment by an integrated gastro-rheumatologic evaluation of articular and gastrointestinal activity, as well patient reported outcomes (PROs) of the HRQoL questionnaires. Read More

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http://dx.doi.org/10.3748/wjg.v23.i39.7139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656461PMC
October 2017
18 Reads

Fever as an initial manifestation of spondyloarthritis: A retrospective study.

PLoS One 2017 14;12(9):e0184323. Epub 2017 Sep 14.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.

Objectives: We aimed to evaluate a wide spectrum of clinical features of adult patients with spondyloarthritis (SpA) whose initial manifestation was fever, using the Assessment of SpondyloArthritis international Society (ASAS) classification criteria.

Methods: We retrospectively collected the electronic medical records of hospitalized SpA patients who initially presented to the Severance Hospital (Seoul, Korea) with fever from January 2010 to May 2016. As a control group, we also recruited one-hundred consecutive patients who were diagnosed with SpA in our outpatient clinic. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184323PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598956PMC
October 2017
13 Reads

Conventional Radiology in Spondyloarthritis.

Radiol Clin North Am 2017 Sep 12;55(5):943-966. Epub 2017 Jun 12.

Department of Radiology, University of Foggia, Viale Luigi Pinto 1, Foggia 71100, Italy; Department of Radiology, Scientific Institute, Casa Sollievo della Sofferenza Hospital, Viale Cappuccini 1, San Giovanni Rotondo, Foggia 71013, Italy.

Spondyloarthritides are of a group of inflammatory rheumatic diseases, with negative rheumatoid factor, associated with the HLA-B27 gene. They comprise ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and enteropathic-related spondylitis. The presence of sacroiliitis represents the most characteristic feature of these disorders and is an important criterion in diagnosis. Read More

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http://dx.doi.org/10.1016/j.rcl.2017.04.003DOI Listing
September 2017
12 Reads

Prevalence of psoriatic arthritis and costs generated by treatment of psoriatic arthritis patients in the public health system - the case of Poland.

Reumatologia 2016;54(6):278-284. Epub 2016 Dec 30.

Department of Internal Medicine and Rheumatology, Military Institute of Medicine Warsaw, Poland.

Objective: The objective of the study was to analyse the prevalence of psoriatic arthritis (PsA) in Poland and to assess the costs generated by treatment of PsA patients in the system of public healthcare.

Material And Methods: The analysis was based on the database of the public payer, the National Health Fund (NFZ). PsA was defined by the diagnostic ICD-10 codes M07 (Enteropathic arthropathies) and L40. Read More

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http://dx.doi.org/10.5114/reum.2016.64902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241363PMC
December 2016
22 Reads

Evidence of IL-17 producing innate lymphoid cells in peripheral blood from patients with enteropathic spondyloarthritis.

Clin Exp Rheumatol 2016 Nov-Dec;34(6):1085-1093. Epub 2016 Oct 21.

Gastrointestinal Unit, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.

Objectives: Both the innate and the adaptive immune responses contribute to the onset of chronic inflammation in spondyloarthritis (SpA). The association between SpA and inflammatory bowel disease (IBD, enteropathic SpA-ESpA) has been largely established and suggests a shared pathophysiology. There is evidence that innate lymphoid cells (ILC) are involved in the pathogenesis of both SpA and IBD while no evidence has been reported to date on ESpA. Read More

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June 2017
33 Reads

Safety, efficacy and immunogenicity of switching from innovator to biosimilar infliximab in patients with spondyloarthritis: a 6-month real-life observational study.

Immunol Res 2017 02;65(1):419-422

Allergology and Immunology Laboratory, S.Giovanni di Dio Hospital, Florence, Italy.

Biosimilar infliximab (INX) was recently approved by the European Medicine Agency for the treatment of rheumatoid arthritis, ankylosing spondylitis (AS), Crohn's disease, ulcerative colitis, psoriatic arthritis (PsA), and psoriasis on the grounds that its pharmacokinetics, safety, and efficacy were comparable to those of innovator INX. The aim of this study was to investigate the real-life efficacy, safety, and immunogenicity of switching from innovator to biosimilar INX in patients with spondyloarthritis (SpA). Forty-one patients attending three Italian rheumatology centres with a previous diagnosis of SpA and clinically inactive or moderate disease activity (ASDAS-CRP < 2. Read More

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http://dx.doi.org/10.1007/s12026-016-8843-5DOI Listing
February 2017
51 Reads

A case of enteropathic arthritis successfully treated with methotrexate.

Nihon Rinsho Meneki Gakkai Kaishi 2016 ;39(3):219-22

Institute of Rheumatology, Tokyo Women's Medical University.

  We report a 36-year-old male patient who suffered from polyarthritis after the remission of ulcerative colitis. He was diagnosed with enteropathic arthritis type 2, against which methotrexate was effective. Read More

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http://dx.doi.org/10.2177/jsci.39.219DOI Listing
March 2017
5 Reads

Dactylitis in enteropathic spondyloarthritis.

Clin Exp Rheumatol 2016 Sep-Oct;34(5):842-847. Epub 2016 Apr 15.

Rheumatology Research Unit, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.

Objectives: Dactylitis has long been recognised as one of the significant features of spondyloarthropathies. In the literature, the prevalence of dactylitis in enteropathic spondyloarthritis (EASpA) ranges between 2% and 4%. The aim of this study was to identify the prevalence of dactylitis in EASpA patients and to investigate its association with clinical subset and with articular and bowel disease activity. Read More

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January 2017
26 Reads

Impact of a multidisciplinary approach in enteropathic spondyloarthritis patients.

Autoimmun Rev 2016 Feb 7;15(2):184-90. Epub 2015 Nov 7.

GI Unit, Dpt. Department of Systems Medicine, University Tor Vergata, Rome, Italy.

Spondyloarthritis (SpA) and inflammatory bowel disease (IBD) are chronic autoinflammatory diseases that partially share the genetic predisposition and the unchecked inflammatory response linking the gut to the joints. The coexistence of both conditions in patients and the increased cross-risk ratios between SpA and IBD strongly suggest a shared pathophysiology. The prevalence of Enteropathic-related Spondyloarthritis (ESpA) in IBD patients shows a wide variation and may be underestimated. Read More

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http://dx.doi.org/10.1016/j.autrev.2015.11.002DOI Listing
February 2016
22 Reads

Costs of Absenteeism In Psoriatic and Enteropathic Arthropathies Based on Real-Life Data From Poland's Social Insurance Institution Database In 2013.

Value Health 2015 Nov 20;18(7):A665. Epub 2015 Oct 20.

Jagiellonian University Medical Collage Institute of Public Health, Krakow, Poland.

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http://dx.doi.org/10.1016/j.jval.2015.09.2424DOI Listing
November 2015
4 Reads

Genetics of ankylosing spondylitis--insights into pathogenesis.

Nat Rev Rheumatol 2016 Feb 6;12(2):81-91. Epub 2015 Oct 6.

NIHR Oxford Musculoskeletal Biomedical Research Unit and Comprehensive Biomedical Research Centre, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK.

Ankylosing spondylitis (AS), an immune-mediated arthritis, is the prototypic member of a group of conditions known as spondyloarthropathies that also includes reactive arthritis, psoriatic arthritis and enteropathic arthritis. Patients with these conditions share a clinical predisposition for spinal and pelvic joint dysfunction, as well as genetic associations, notably with HLA-B(*)27. Spondyloarthropathies are characterized by histopathological inflammation in entheses (regions of high mechanical stress where tendons and ligaments insert into bone) and in the subchondral bone marrow, and by abnormal osteoproliferation at involved sites. Read More

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http://www.nature.com/articles/nrrheum.2015.133
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http://dx.doi.org/10.1038/nrrheum.2015.133DOI Listing
February 2016
5 Reads

Seronegative reactive spondyloarthritis and the skin.

Clin Dermatol 2015 Sep-Oct;33(5):531-7. Epub 2015 May 27.

Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano, Milan, Italy; BIOMETRA Department, University of Milan, Milan, Italy. Electronic address:

Spondyloarthritidies represent a group of conditions affecting the axial and peripheral muscoloskeletal apparatus and are often associated with psoriasis, infections, and inflammatory bowel diseases. Other diseases included in this category are psoriatic arthritis, ankylosing spondylitis, and enteropathic arthritis. Reactive arthritis is an elusive spondyloarthritis, commonly occurring 1 to 3 weeks after a digestive or a genitourinary tract infection, in which microorganisms do not infect the joint directly. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2015.05.004DOI Listing
June 2016
9 Reads

Two-year incidence of psoriasis, uveitis and inflammatory bowel disease in patients with spondyloarthritis: A study in the AQUILES cohort.

Reumatol Clin 2016 Jan-Feb;12(1):22-6. Epub 2015 Feb 13.

Departamento de Medical Affairs, Merck Sharp & Dohme de España, S. A., Madrid, España.

Objectives: To describe the 2-year incidence of new extra-articular manifestations (uveitis, psoriasis, inflammatory bowel disease) in a cohort of patients with spondyloarthritis included in the AQUILES study.

Patients: Over a period of 2 years, 513 patients with spondyloarthritis (62.5% males, mean age 48 years) diagnosed with ankylosing spondylitis (AS) (55. Read More

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http://dx.doi.org/10.1016/j.reuma.2015.01.002DOI Listing
February 2017
9 Reads

Spondyloarthritis and the microbiome: new insights from an ancient hypothesis.

Curr Rheumatol Rep 2015 Feb;17(2):10

Division of Rheumatology, Department of Medicine, New York University School Medicine, New York, NY, USA.

The human microbiome, which represents the total collection of microorganisms (and their genes) inhabiting the human body, has increasingly been recognized as a potential key factor in the development of autoimmune disease. Multiple studies suggest that the microbiome has significant influence on immune homeostasis, while disruptions in local microbiome composition can result in a heightened systemic inflammatory response. The intestinal microbiome, in particular, harbors the densest assembly of bacteria and appears to influence the immune system in the context of inflammatory arthropathies. Read More

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http://dx.doi.org/10.1007/s11926-014-0487-7DOI Listing
February 2015
5 Reads

Extra-articular disease in patients with spondyloarthritis. Baseline characteristics of the spondyloarthritis cohort of the AQUILES study.

Reumatol Clin 2015 Mar-Apr;11(2):83-9. Epub 2014 Nov 11.

Hospital Gregorio Marañón, Madrid, España.

Objectives: To describe the prevalence of extra-articular disease (uveitis, psoriasis and inflammatory bowel disease [IBD]), in a cohort of patients with spondyloarthritis (SpA).

Patients And Methods: AQUILES is an observational, prospective and multicentric study of three cohorts of patients with one of the following immune-mediated inflammatory diseases (IMID): SpA, psoriasis, or IBD. In the present cohort, patients ≥18 years of age with SpA were enrolled from Rheumatology clinics. Read More

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http://dx.doi.org/10.1016/j.reuma.2014.04.003DOI Listing
December 2016
62 Reads

Costs of Absenteeism In Psoriatic and Enteropathic Arthropathies Based On Real-Life Data From Poland's Social Insurance Institution Database In 2012.

Value Health 2014 Nov 26;17(7):A528. Epub 2014 Oct 26.

Jagiellonian University Medical College, Krakow, Poland.

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http://dx.doi.org/10.1016/j.jval.2014.08.1669DOI Listing
November 2014
4 Reads

Ankylosing spondylitis in a military aviator: air medical considerations.

Air Med J 2014 May-Jun;33(3):115-7

Aerospace Medicine Research Center, Aerospace and Subaquatic Medicine School, AJA University of Medical Sciences, Tehran, Iran.

Rheumatologic diseases are a challenging diagnosis when it comes to air medical disposition decision making because many of these diseases overlap and their initial presentation is insidious and relapsing remitting in future scope. Many rheumatologic diseases have musculoskeletal and other organ complications. One of these diagnoses is spondyloarthritides. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1067991X140002
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http://dx.doi.org/10.1016/j.amj.2014.01.004DOI Listing
August 2015
10 Reads

Enteropathic arthritis in Brazil: data from the Brazilian Registry of Spondyloarthritis.

Rev Bras Reumatol 2013 Nov-Dec;53(6):452-9

Unlabelled: Inflammatory bowel diseases (Crohn's disease and ulcerative rectocolitis) have extraintestinal manifestations 25% of the patients, with the most common one being the enteropathic arthritis.

Methods: Prospective, observational, multicenter study with patients from 29 reference centers participating in the Brazilian Registry of Spondyloarthritis (RBE), which incorporates the RESPONDIA (Ibero-American Registry of Spondyloarthritis) group. Demographic and clinical data were collected from 1472 patients and standardized questionnaires for the assessment of axial mobility, quality of life, enthesitic involvement, disease activity and functional capacity were applied. Read More

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http://dx.doi.org/10.1016/j.rbr.2013.04.001DOI Listing
April 2015
22 Reads

Involvement of IL-23 in enteropathic arthritis patients with inflammatory bowel disease: preliminary results.

Clin Rheumatol 2014 May 3;33(5):713-7. Epub 2014 Jan 3.

Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt,

The role of interleukin (IL)-23 in the pathogenesis of inflammatory bowel disease (IBD) remains unclear. The aim of this work was to study the serum level of IL-23 in IBD with and without arthritis and determine its relation to the subsets and clinical features of the disease. Thirty-seven patients with IBD including 11 with arthritis were included in the study with a mean age of 30. Read More

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http://dx.doi.org/10.1007/s10067-013-2469-yDOI Listing
May 2014
16 Reads

Seronegative spondyloarthropathies: what radiologists should know.

Radiol Med 2014 Mar 22;119(3):156-63. Epub 2013 Nov 22.

S.C. di Radiodiagnostica, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy,

Inflammatory involvement of the spine and sacroiliac joints is the most peculiar feature of seronegative spondyloarthropathies (SpA), which include ankylosing spondylitis, psoriatic arthritis, reactive arthritis (Reiter's syndrome), enteropathic spondylitis (related to inflammatory bowel diseases) and undifferentiated spondyloarthropathies. SAPHO syndrome may also be considered a SpA, but there is no clear agreement in this respect. Imaging, along with clinical and laboratory evaluation, is an important tool to reach a correct diagnosis and to provide a precise grading of disease progression, influencing both clinical management and therapy. Read More

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http://dx.doi.org/10.1007/s11547-013-0316-5DOI Listing
March 2014
19 Reads

Effect of enthesitis on 1505 Brazilian patients with spondyloarthritis.

J Rheumatol 2013 Oct 15;40(10):1719-25. Epub 2013 Jul 15.

From the Brazilian Registry of Spondyloarthritis: Universidade Federal do Rio de Janeiro, Universidade Estadual do Rio de Janeiro, Santa Casa do Rio de Janeiro, and Faculdade de Medicina Souza Marques, Rio de Janeiro; Insper Institute of Education and Research, and Division of Rheumatology and Instituto de Ortopedia e Traumatologia, Universidade de São Paulo, and Santa Casa de São Paulo, and Hospital do Servidor Público Estadual, São Paulo; Universidade de Brasília, and Hospital de Base, Brasília; Hospital Geral de Goiânia, Goiânia; Universidade de Campinas, and Pontifícia Universidade Católica, Campinas; Universidade Federal do Amazonas, Manaus; Pontifícia Universidade Católica, Porto Alegre; Hospital Evangélico de Curitiba, and Universidade Federal do Paraná, Curitiba; Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto; Hospital Geral de Fortaleza, and Universidade Federal do Ceará, Fortaleza; Universidade Federal do Mato Grosso do Sul, Campo Grande; Universidade Federal de Pernambuco, Recife; Universidade Federal do Rio Grande do Sul, Porto Alegre; Universidade Federal de Santa Catarina, Florianópolis; Santa Casa de Belo Horizonte, and Universidade Federal de Minas Gerais, Belo Horizonte; Escola de Medicina e Saúde Pública, Salvador; Universidade Federal do Pará, Belém; and Universidade Federal do Espírito Santo, Vitória, Brazil.

Objective: To analyze the clinical effect of enthesitis in a large Brazilian cohort of patients with spondyloarthritis (SpA).

Methods: A common protocol of investigation was prospectively applied to 1505 patients with SpA in 29 centers in Brazil. Clinical and demographic variables and disease indexes were investigated. Read More

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http://www.jrheum.org/cgi/doi/10.3899/jrheum.121145
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http://dx.doi.org/10.3899/jrheum.121145DOI Listing
October 2013
81 Reads

The link between ankylosing spondylitis, Crohn's disease, Klebsiella, and starch consumption.

Clin Dev Immunol 2013 27;2013:872632. Epub 2013 May 27.

Analytical Sciences Group, Kings College, London, UK.

Both ankylosing spondylitis (AS) and Crohn's disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen, Klebsiella pneumoniae, is the most likely triggering factor involved in the initiation and development of these diseases. Increased starch consumptions by genetically susceptible individuals such as those possessing HLA-B27 allelotypes could trigger the disease in both AS and CD by enhancing the growth and perpetuation of the Klebsiella microbes in the bowel. Read More

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http://dx.doi.org/10.1155/2013/872632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678459PMC
December 2013
11 Reads

Enteropathic spondyloarthritis: from diagnosis to treatment.

Clin Dev Immunol 2013 15;2013:631408. Epub 2013 Apr 15.

Rheumatology Research Unit, University Federico II, 80131 Naples, Italy.

Enteropathic arthritis (EA) is a spondyloarthritis (SpA) which occurs in patients with inflammatory bowel diseases (IBDs) and other gastrointestinal diseases. Diagnosis is generally established on the medical history and physical examination. It was, generally, made according to the European Spondyloarthropathy Study Group (ESSG) criteria. Read More

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http://dx.doi.org/10.1155/2013/631408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649644PMC
December 2013
22 Reads
7 Citations
2.934 Impact Factor

Discovertebral erosions in patients with enteropathic spondyloarthritis.

J Rheumatol 2012 Dec 15;39(12):2332-40. Epub 2012 Oct 15.

Rheumatology Research Unit, Gastroenterology Research Unit, Department of Clinical and Experimental Medicine, University Federico II, Naples, Italy.

Objective: Magnetic resonance imaging (MRI) is considered the modality of choice for the diagnosis of spondyloarthropathy (SpA)-related spondylodiscitis, or discovertebral erosions (DE). Our aim was to analyze the prevalence and the clinical features of DE in patients with enteropathic SpA (EA) using MRI.

Methods: We evaluated 72 patients with EA and 43 controls for the study. Read More

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http://dx.doi.org/10.3899/jrheum.120415DOI Listing
December 2012
6 Reads

Effect of age at disease onset in the clinical profile of spondyloarthritis: a study of 1424 Brazilian patients.

Clin Exp Rheumatol 2012 May-Jun;30(3):351-7. Epub 2012 Jun 25.

Hospital Evangélico de Curitiba, Brazil.

Objectives: To analyse demographic and clinical variables in patients with disease onset before and after 40, 45 and 50 years in a large series of Brazilian SpA patients.

Methods: A common protocol of investigation was prospectively applied to 1424 SpA patients in 29 centres distributed through the main geographical regions in Brazil. The mean age at disease onset was 28. Read More

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September 2012
16 Reads

Diagnosis and classification in spondyloarthritis: identifying a chameleon.

Nat Rev Rheumatol 2012 Mar 27;8(5):253-61. Epub 2012 Mar 27.

Department of Medicine, Division of Rheumatology, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands.

Spondyloarthritis (SpA) defines a group of interrelated diseases, including ankylosing spondylitis (AS), psoriatic arthritis, reactive arthritis, enteropathic-related spondylitis and arthritis, and undifferentiated SpA. The clinical presentation of SpA is heterogeneous, and no single shared distinguishing feature exists for the conditions comprising SpA; in daily practice, diagnosis is usually made on the basis of a combination of symptoms, the findings of physical examination, imaging and laboratory investigations. Several classification criteria have been developed for AS and SpA, which are useful in a research setting but cannot be automatically applied to the diagnosis of individual patients. Read More

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http://dx.doi.org/10.1038/nrrheum.2012.33DOI Listing
March 2012
15 Reads

Spondyloarthropathies: new directions in etiopathogenesis, diagnosis and treatment.

Mo Med 2012 Jan-Feb;109(1):69-74

University of Missouri School of Medicine, Division of Immunology and Rheumatology, USA.

The spondyloarthropathies (SpA) are a group of inflammatory rheumatic diseases affecting the spine, peripheral joints and nonarticular structures. Often referred to as "seronegative" due to the absence of rheumatoid factor, SpA include ankylosing spondylitis (AS), reactive arthritis (ReA), enteropathic (IBD) associated arthritis, psoriatic arthritis (PsA), as well as undifferentiated, and juvenile SpA. A broad and overlapping spectrum of disease presentations creates difficulties in determining an initial diagnosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181686PMC
May 2012
14 Reads

Clinico-pathological correlation of non specific inflammation in bowel histology with joint manifestation in a tertiary center in South India.

Rheumatol Int 2013 Aug 19;33(8):2149-52. Epub 2012 Jan 19.

Christian Medical College and Hospital, Vellore, Tamilnadu, India.

The aim of our study was to determine whether the pattern of arthropathy in patients with suspected enteropathic arthritis bore any relation to their gut histology and specifically to chronic nonspecific gut inflammation. Records of 39 patients with suspected enteropathic arthritis from rheumatology clinic between January 2006 and December 2008 who had undergone ileocolonoscopic biopsy were analyzed retrospectively. Patients were grouped into 3 categories, namely those with normal bowel histology, those with mild nonspecific chronic changes, and those with histology suggestive of inflammatory bowel disease. Read More

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http://dx.doi.org/10.1007/s00296-011-2332-xDOI Listing
August 2013
9 Reads
1.630 Impact Factor

Ethnic influence in clinical and functional measures of Brazilian patients with spondyloarthritis.

J Rheumatol 2012 Jan 1;39(1):141-7. Epub 2011 Nov 1.

Disciplina de Reumatologia, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Arnaldo, 455-3, Andar, Cerqueira César, São Paulo SP, Brasil, CEP 01246-903.

Objective: Spondyloarthritides (SpA) can present different disease spectra according to ethnic background. The Brazilian Registry of Spondyloarthritis (RBE) is a nationwide registry that comprises a large databank on clinical, functional, and treatment data on Brazilian patients with SpA. The aim of our study was to analyze the influence of ethnic background in SpA disease patterns in a large series of Brazilian patients. Read More

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http://dx.doi.org/10.3899/jrheum.110372DOI Listing
January 2012
30 Reads

[Chlamydia-associated arthritis and enteropathic arthritis--two important spondyloarthritides].

Nihon Rinsho Meneki Gakkai Kaishi 2011 ;34(3):121-30

Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.

Spondyloarthritis (SpA) includes reactive arthritis (ReA) and enteropathic arthritis (EA), which are clinically important but often misdiagnosed. ReA, sterile inflammatory arthritis, arises after certain genitourinary or gastrointestinal infections. Chlamydia are the most common pathogens causing ReA; ReA due to Chlamydia infection is called Chlamydia-associated arthritis (Chl-AA). Read More

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November 2011
5 Reads

Usefulness of wireless capsule endoscopy for detecting inflammatory bowel disease in children presenting with arthropathy.

Eur J Pediatr 2011 Oct 4;170(10):1343-7. Epub 2011 Jun 4.

Department of Sciences of Reproduction and Development, Institute of Child Health IRCCS Burlo Garofolo, University of Trieste, Via dell'Istria 65/1, 34100 Trieste, Italy.

Inflammatory bowel disease (IBD) is a cause of chronic intestinal inflammation in children. In a subset of patients affected by IBD, arthropathy may be the leading presenting sign. In the past years, remarkable advances in gastrointestinal endoscopy techniques have been achieved; recently, the development of capsule endoscopy (CE) provided a non-invasive method for the complete endoscopic evaluation, including small bowel assessment. Read More

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http://dx.doi.org/10.1007/s00431-011-1505-7DOI Listing
October 2011
5 Reads

Epidemiology of spondyloarthritis in North America.

Authors:
John D Reveille

Am J Med Sci 2011 Apr;341(4):284-6

Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

Many challenges have made it difficult to determine the prevalence of spondyloarthritis (SpA) in North America. They include the ethnic heterogeneity of the population, the lack of feasibility of applying current criteria (such as requirements for human leukocyte antigen-B27 testing and imaging studies such as pelvic radiographs and magnetic resonance imaging scanning) and the transient nature of some SpA symptoms (ie, peripheral arthritis and enthesitis). Current estimates of the prevalence of SpA in the United States range between 0. Read More

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http://dx.doi.org/10.1097/MAJ.0b013e31820f8c99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063892PMC
April 2011
5 Reads

Early spondyloarthritis in multiracial society: differences between gender, race, and disease subgroups with regard to first symptom at presentation, main problem that the disease is causing to patients, and employment status.

Rheumatol Int 2012 Jun 17;32(6):1597-604. Epub 2011 Feb 17.

Department of Rheumatology and Rehabilitation, Barking Havering and Redbridge University NHS Trust, King George Hospital, Barley Lanes, Goodmayes, Ilford, Essex, London, IG3 8YB, UK.

To determine whether the first presenting symptoms, the main problem that the disease is causing to patients, and the employment status at presentation of patients with early spondyloarthritis (SpA) in a multicultural/multiracial patient cohort are different between gender, race, and disease subgroups of the SpA spectrum (ankylosing spondylitis, enteropathic arthritis, psoriatic arthritis, or undifferentiated arthritis). All patients above the age of 16 years, with disease duration of less than 3 years since symptom onset, seen in clinic between 2004 and 2008 with spondyloarthritis (SpAs) were assessed regarding their first presenting symptom, the main problem caused by the disease, and their employment status. In addition, clinical parameters such as the degree of disease activity (measured by BASDAI, ESR, and CRP), functional ability (measured by BASFI), night pain, sleep disturbance, well-being over past week, and over past 6 months prior to assessment (measured by a 10 cm VAS; 0 = good health, 10 = worst possible) were obtained. Read More

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http://dx.doi.org/10.1007/s00296-010-1680-2DOI Listing
June 2012
17 Reads

The genetic basis of spondyloarthritis: SPARTAN/IGAS 2009.

J Rheumatol 2010 Dec;37(12):2626-31

University of Bristol, Bristol, UK.

A joint meeting was held in July 2009 in Houston, Texas, of members of the Spondyloarthritis Research and Therapy Network (SPARTAN), founded in 2003 to promote research, education, and treatment of ankylosing spondylitis (AS) and related forms of spondyloarthritis (SpA), and members of International Genetics of AS (IGAS), founded in 2003 to encourage and coordinate studies internationally in the genetics of AS. The general topic was the genetic basis of SpA, with presentations on the future of human genetic studies; microbes, SpA, and innate immunity; susceptibility of AS to the major histocompatibility complex (MHC) and non-MHC; and individual discussions of the genetics of psoriasis and psoriatic arthritis, uveitis, inflammatory bowel disease, and enteropathic arthritis. Summaries of those discussions are presented. Read More

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http://dx.doi.org/10.3899/jrheum.100892DOI Listing
December 2010
10 Reads

[The clinical characters of 30 patients with enteropathic arthritis and literature review].

Zhonghua Nei Ke Za Zhi 2010 Mar;49(3):223-5

Department of Rheumatology, Chinese PLA General Hospital, Beijing 100853, China.

Objective: To better understand the clinical characters of enteropathic arthritis patients.

Methods: The clinical, laboratory and X-rays data of 30 enteropathic arthritis in-patients were analyzed.

Results: Among the 30 patients, 14 were male, 16 were female. Read More

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March 2010
5 Reads

The Bath Ankylosing Spondylitis Activity and Function Indices (BASDAI and BASFI) and their correlation with main symptoms experienced by patients with spondyloarthritis.

Clin Rheumatol 2010 Aug 14;29(8):869-74. Epub 2010 Mar 14.

Department of Rheumatology and Rehabilitation, Barking Havering and Redbridge University Hospitals NHS Trust, King George Hospital, Barley Lanes, Goodmayes, Essex IG3 8YB, UK.

With the aim of assessing whether the Bath Ankylosing Spondylitis Activity and Function Indices (BASDAI and BASFI) are reliable measures of disease activity and function in patients with spondyloarthritides (SpAs), 341 patients with SpA (representing ankylosing spondylitis (14.5%), psoriatic arthritis (27.3%), enteropathic arthritis (6. Read More

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http://link.springer.com/10.1007/s10067-010-1411-9
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http://dx.doi.org/10.1007/s10067-010-1411-9DOI Listing
August 2010
11 Reads

Enteropathic spondyloarthropathy: a common genetic background with inflammatory bowel disease?

World J Gastroenterol 2009 May;15(20):2456-62

Department of Medical Sciences, Unit of Gastroenterology, IRCCSCSS Hospital, San Giovanni Rotondo, Italy.

The association between spondyloarthropathy and inflammatory bowel disease (IBD) is largely established, although prevalence is variable because of different population selection and diagnostic methodologies. Most studies indicate that as many as 10%-15% of cases of IBD are complicated by ankylosing spondylitis (AS) or other forms of spondylarthritis (SpA). Of note, ileal inflammation resembling IBD has been reported in up to two thirds of cases of SpA, and it has been suggested that the presence of ileitis is associated with the chronicity of articular complications. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686902PMC
May 2009
5 Reads

[Enteropathic arthritis: water in the intestines, fire in the joints].

Authors:
M Ronneberger

Z Rheumatol 2009 Jun;68(4):329-34; quiz 335-6

Medizinische Klinik 3, Rheumatologie und Immunologie, Universität Erlangen-Nürnberg, Ulmenweg 18, Erlangen, Germany.

Patients with various kinds of intestinal illnesses sometimes suffer not only abdominal symptoms, but also joint involvement, leading to a reduction in quality of life. Diseases leading to inflammatory joint involvement such as inflammatory bowel disease, Whipple's disease or surgical intestinal bypass, are classified as enteropathic arthritis. In all cases, disrupted barrier function of the intestine causes activation of the immune system and inflammation of joints. Read More

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http://dx.doi.org/10.1007/s00393-009-0465-zDOI Listing
June 2009
5 Reads

Indications and challenges of probiotics, prebiotics, and synbiotics in the management of arthralgias and spondyloarthropathies in inflammatory bowel disease.

J Clin Gastroenterol 2008 Sep;42 Suppl 3 Pt 1:S136-41

Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands.

Arthralgia and spondyloarthropathy of the peripheral and the axial joints are common in patients with inflammatory bowel diseases. Evidence for this association has been provided by clinical, epidemiologic, and immunologic studies confirming the presence of shared inflammatory pathways in gut and joint. Bacterial gut infections such as Salmonella typhimurium, Yersinia enterocolitica, Shigella, Campylobacter jejuni may induce reactive peripheral arthritis and 20% of these patients may develop chronic spondyloarthropathy. Read More

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http://dx.doi.org/10.1097/MCG.0b013e3181662455DOI Listing
September 2008
7 Reads

Imaging of the seronegative anterior chest wall (ACW) syndromes.

Clin Rheumatol 2008 Jul 24;27(7):815-21. Epub 2008 May 24.

Department of Radiology, University of Foggia, Viale Luigi Pinto 1, Foggia 71100, Italy.

The sternocostoclavicular (SCC) region is subject to the same diseases that occur in joints, with congenital and developmental anomalies, inflammatory and infectious diseases, soft tissue and bone tumors as well as the seronegative spondyloarthropathies, including ankylosing spondylitis, reactive arthritis, enteropathic arthritis, psoriatic arthritis, pustulosis palmoplantaris and other syndromes. Most of these conditions present with swelling of the joint, which may be associated with pain and/or tenderness. These disorders are characterised by onset usually before the age of 40 years, absence of serum autoantibodies and sometimes the association with antigen human leukocyte antigen B27. Read More

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http://dx.doi.org/10.1007/s10067-008-0905-1DOI Listing
July 2008
9 Reads

Incidence and characteristics of arthritis in Norwegian children: a population-based study.

Pediatrics 2008 Feb 28;121(2):e299-306. Epub 2008 Jan 28.

Department of Rheumatology, Rikshospitalet Medical Centre, N-0027 Oslo, Norway.

Objective: The purpose of this work was to assess the annual incidence of arthritis in children and describe early disease and patient characteristics, microbiologic features, and immunogenetic factors in children with different subgroups of childhood arthritis.

Patients And Methods: A population-based multicenter study was performed in southeastern Norway between June 1, 2004, and May 31, 2005. The total population of children under 16 years of age was 255,303. Read More

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http://dx.doi.org/10.1542/peds.2007-0291DOI Listing
February 2008
25 Reads