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PLoS One 2022 27;17(6):e0269850. Epub 2022 Jun 27.

Reference Laboratory for Microbiology, Executive Department of Reference Laboratories, Research and Laboratories Sector, Saudi Food and Drug Authority (SFDA), Riyadh, Saudi Arabia.

The incidence of hospital- and community-acquired infections has been dramatically increased worldwide. Accordingly, hands hygiene and the use of disinfectants have been increased leading to the expansion in hand sanitizers production to meet public demand. This study was conducted to assess the efficiency of common disinfectants in the market of Riyadh, Saudi Arabia in inhibiting the microbial growth during the time of Coronavirus disease 2019 (COVID-19) pandemic. Read More

J Bacteriol 2022 Jun 27:e0061521. Epub 2022 Jun 27.

Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological Universitygrid.59025.3b, Singapore.

Enterococcus faecalis is often coisolated with Pseudomonas aeruginosa in polymicrobial biofilm-associated infections of wounds and the urinary tract. As a defense strategy, the host innately restricts iron availability at infection sites. Despite their coprevalence, the polymicrobial interactions of these two species in biofilms and under iron-restricted conditions remain unexplored. Read More

J Enzyme Inhib Med Chem 2022 Dec;37(1):1838-1844

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, USA.

Vancomycin-resistant enterococci (VRE), consisting of pathogenic , is a leading cause of hospital-acquired infections (HAIs). We recently repurposed the FDA-approved human carbonic anhydrase (CA) inhibitor acetazolamide () against VRE agent with the likely mechanism of action for the molecules being inhibition of one, or both, of the bacterial CA isoforms expressed in VRE. To elucidate how inhibitor binding to the enzymes relates to MIC, we further characterised the inhibition constants () against the α-CA (-CA) and γ-CA (γ-CA), as well as against human CA I (hCAI) and human CA II (hCAII) to assess selectivity. Read More

J Dent Sci 2022 Apr 9;17(2):836-841. Epub 2021 Oct 9.

Songha Yoo Seunghoon Pediatric Dentistry, Cheonan, South Korea.

Background/purpose: Because complete microbial elimination of the infected root canal system is nearly impossible to achieve, the use of root canal fillings with antibacterial effects may help to minimize intracanal infections. Our previous study, MTA modified by CaF addition, improved the biocompatibility and mineralization potential of human dental pulp cells without adverse effect on the physical properties. In this study, the antibacterial effect of MTA after CaF addition was evaluated for use as a root canal sealer. Read More

Front Microbiol 2022 9;13:913023. Epub 2022 Jun 9.

Department of Microbiology, Army Medical University, Chongqing, China.

is a common gram-positive non-spore-forming bacterium in nature and is found in the upper respiratory tract, intestine, and mouth of healthy people. is also one of the common pathogens causing nosocomial infections and is resistant to several antibiotics commonly used in practice. Thus, treating drug-resistant with antibiotics is challenging, and new approaches are needed. Read More

J Insect Physiol 2022 Jun 23:104415. Epub 2022 Jun 23.

Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, India. Electronic address:

The density-dependent prophylaxis hypothesis predicts that risk of pathogen transmission increases with increase in population density, and in response to this, organisms mount a prophylactic immune response when exposed to high density. This prophylactic response is expected to help organisms improve their chances of survival when exposed to pathogens. Alternatively, organisms living at high densities can exhibit compromised defense against pathogens due to lack of resources and density associated physiological stress; the crowding stress hypothesis. Read More

Int J Infect Dis 2022 Jun 22. Epub 2022 Jun 22.

Asia-Pacific Foundation for Infectious Diseases, Suite 1712, Rosedale Officetel 280, Gwangpyeong-ro, Gangnam-gu, Seoul 06367, Republic of Korea.

Objectives: Vancomycin and teicoplanin are glycopeptides with activity against Enterococcus faecium. However, studies on the clinical efficacy of teicoplanin are limited. The present study was aimed to compare the therapeutic efficacy of teicoplanin and vancomycin in E. Read More

Indian Pediatr 2022 Jun 11. Epub 2022 Jun 11.

Department of Biostatistics, St. John's Medical College and Hospital, Bengaluru, Karnataka.

Objective: To describe the occurrence, microbiology, and risk factors of catheter- associated urinary tract infections (CA-UTI) in critically ill children.

Methods: We conducted a review of hospital records for CA-UTI in the pediatric intensive care unit (PICU) over a 7-year period (2014-2020).

Results: 62-CAUTI cases (48% boys, median (IQR) age 36 (12,96 month) were identified during the study period with occurrence rate of 7. Read More

Sci Rep 2022 Jun 24;12(1):10778. Epub 2022 Jun 24.

Department of Chemistry, University of Surrey, Guildford, GU27XH, UK.

There is a great demand from patients requiring skin repair, as a result of poorly healed acute wounds or chronic wounds. These patients are at high risk of constant inflammation that often leads to life-threatening infections. Therefore, there is an urgent need for new materials that could rapidly stimulate the healing process and simultaneously prevent infections. Read More

J Antimicrob Chemother 2022 Jun 24. Epub 2022 Jun 24.

Division of Microbiology, CSIR-Central Drug Research Institute, Sitapur Road, Sector 10, Janakipuram Extension, Lucknow-226031, Uttar Pradesh, India.

Background: Antimicrobial resistance is a growing menace, claiming millions of lives all over the world. In this context, drug repurposing is one approach gaining interest as a suitable alternative to conventional drug discovery and development.

Methods: Whole-cell assays were used to screen FDA-approved drugs to identify novel antimicrobial agents active against bacterial pathogens. Read More

Sensors (Basel) 2022 Jun 20;22(12). Epub 2022 Jun 20.

Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.

Nosocomial infection is one of the most important problems that occurs in hospitals, as it directly affects susceptible patients or patients with immune deficiency. ( is the most common cause of nosocomial infections in hospitals. can cause various diseases such as pneumonia, urinary tract infections, septicemias, and soft tissue infections, and it has also become highly resistant to antibiotics. Read More

Pharmaceutics 2022 May 31;14(6). Epub 2022 May 31.

Saint-Petersburg Pasteur Institute, Street Mira, 14, 197101 St. Petersburg, Russia.

Bacterial infections have accompanied humanity throughout its history and became vitally important in the pandemic area. The most pathogenic bacteria are multidrug-resistant strains, which have become widespread due to their natural biological response to the use of antibiotics, including uncontrolled use. The current challenge is finding highly effective antibacterial agents of natural origin, which, however, have low solubility and consequently poor bioavailability. Read More

Pathogens 2022 Jun 8;11(6). Epub 2022 Jun 8.

Department of Human Pathology, University of Messina, 98125 Messina, Italy.

Infections caused by bacteria have a major impact on public health-related morbidity and mortality. Despite major advances in the prevention and treatment of bacterial infections, the latter continue to represent a significant economic and social burden worldwide. The WHO compiled a list of six highly virulent multidrug-resistant bacteria named ESKAPE (, , , , , and species) responsible for life-threatening diseases. Read More

Microorganisms 2022 Jun 15;10(6). Epub 2022 Jun 15.

Department of Bacteriology, Microbial Ecology and Parasitology, Chair of Microbiology, Jagiellonian University Medical College, 31-121 Cracow, Poland.

Many difficult-to-treat human infections related to catheters and other indwelling devices are caused by bacteria residing in biofilms. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial agents. Therefore, many different approaches have been researched to destroy or inhibit biofilm production by bacteria. Read More

Microorganisms 2022 Jun 6;10(6). Epub 2022 Jun 6.

Department of Endodontics, Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

The physiology of an organism in the environment reflects its interactions with the diverse physical, chemical, and biological properties of the surface. These principles come into consideration during model selection to study biofilm-host interactions. Biofilms are communities formed by beneficial and pathogenic bacteria, where cells are held together by a structured extracellular matrix. Read More

Antibiotics (Basel) 2022 Jun 8;11(6). Epub 2022 Jun 8.

Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 779 00 Olomouc, Czech Republic.

This observational retrospective study aimed to analyze whether/how the spectrum of bacterial pathogens and their resistance to antibiotics changed during the worst part of the COVID-19 pandemic (1 November 2020 to 30 April 2021) among intensive care patients in University Hospital Olomouc, Czech Republic, as compared with the pre-pandemic period (1 November 2018 to 30 April 2019). A total of 789 clinically important bacterial isolates from 189 patients were cultured during the pre-COVID-19 period. The most frequent etiologic agents causing nosocomial infections were strains of (17%), (11%), (10%), coagulase-negative staphylococci (9%), (8%), (6%), (5%), (5%) and (5%). Read More

Antibiotics (Basel) 2022 Jun 3;11(6). Epub 2022 Jun 3.

Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.

Urinary tract infections (UTIs) are one of the most common infectious diseases at the community level. The continue misuse of antimicrobials is leading to an increase in bacterial resistance, which is a worldwide problem. The objective of this work was to study the incidence and pattern of antimicrobial resistance of the main bacteria responsible for UTI in the community of central and northern Portugal, and establish an appropriate empirical treatment. Read More

Antibiotics (Basel) 2022 Jun 3;11(6). Epub 2022 Jun 3.

Section of Microbiology, Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy.

The World Health Organization has identified antimicrobial resistance as a public health emergency and developed a global priority pathogens list of antibiotic-resistant bacteria that can be summarized in the acronym ESKAPE (, , , , and species), reminding us of their ability to escape the effect of antibacterial drugs. We previously tested new heteroaryl-ethylene compounds in order to define their spectrum of activity and antibacterial capability. Now, we focus our attention on PB4, a compound with promising MIC and MBC values in all conditions tested. Read More

Antibiotics (Basel) 2022 May 25;11(6). Epub 2022 May 25.

Department of Clinical Infectious Diseases, Aichi Medical University, Nagakute 480-1195, Japan.

Vancomycin or daptomycin is administered to hemodialysis patients infected with methicillin-resistant and species. Although serious concerns regarding nephrotoxicity due to vancomycin have been raised, it might not be a critical issue in hemodialysis patients. Moreover, very few studies have investigated the effectiveness of vancomycin versus daptomycin in patients undergoing hemodialysis. Read More

Sci Rep 2022 Jun 23;12(1):10675. Epub 2022 Jun 23.

Department of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159c St., 02-776, Warsaw, Poland.

Enterococcus cecorum is a well-known component of the normal poultry intestinal microbiota and an important bacterial pathogen. Infections caused by E. cecorum have negative effects on the poultry production worldwide. Read More

Commun Biol 2022 Jun 23;5(1):619. Epub 2022 Jun 23.

Department of Infectious Diseases, Tohoku University Graduate School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

Serine hydroxymethyltransferase (SHMT) produces 5,10-methylenetetrahydrofolate (CH-THF) from tetrahydrofolate with serine to glycine conversion. SHMT is a potential drug target in parasites, viruses and cancer. (+)-SHIN-1 was developed as a human SHMT inhibitor for cancer therapy. Read More

J Clin Microbiol 2022 Jun 23:e0002122. Epub 2022 Jun 23.

bioMérieux, La Balme les Grottes, France.

Fosfomycin is a phosphonic acid derivative active against a wide spectrum of Gram-positive and Gram-negative pathogens. It is used for the treatment of uncomplicated urinary tract infections (uUTI) or severe infections by oral or intravenous (i.v. Read More

Maedica (Bucur) 2022 Mar;17(1):211-214

Department of Internal Medicine, University Hospital of Heraklion, Crete, Greece.

is a widely distributed fungus that has evolved as an important pathogen, especially in immunocompromised individuals, causing fungemias, central nervous system infections, peritoneal dialysis-associated peritonitis and keratitis. Even though there are a few reports of skin and soft tissue infections caused by , all these cases involve immunocompromised individuals. is a Gram-positive bacterium known to cause several infections such as bloodstream, urinary tract and skin and soft tissue infections. Read More

Microbiol Spectr 2022 Jun 22:e0095422. Epub 2022 Jun 22.

Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.

Infections caused by multiresistant pathogens have become a major problem in both human and veterinary medicine. Due to the declining efficacy of many antibiotics, new antimicrobials are needed. Promising alternatives or additions to antibiotics are bacteriocins, antimicrobial peptides of bacterial origin with activity against many pathogens, including antibiotic-resistant strains. Read More

Front Biosci (Schol Ed) 2022 Apr;14(2):11

Department of Biology and General Genetics, Institute of Medicine, RUDN University, 117198 Moscow, Russia.

The search for new antimicrobials is essential to address the worldwide issue of antibiotic resistance. The present work aimed at assessing the antimicrobial activity of L. (horse chestnut) bark against bacteria involved in urinary tract infections (UTIs). Read More

J Appl Biomed 2022 Jun 6;20(2):45-55. Epub 2022 Jun 6.

Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.

Open wounds are easily susceptible to infection by multi-drug resistant (MDR) pathogens. The emergence of MDR super bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus spp, fungi such as Aspergillus niger and Candida spp, has been identified to significantly increase the incidence rate. Therefore, it is necessary to develop a suitable barrier to prevent infection and enhance wound healing. Read More

Biofilm 2022 Dec 14;4:100079. Epub 2022 Jun 14.

Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.

In patients with acute respiratory failure, mechanical ventilation through an endotracheal tube (ET) may be required to correct hypoxemia and hypercarbia. However, biofilm formation on these ETs is a risk factor for infections in intubated patients, as the ET can act as a reservoir of microorganisms that can cause infections in the lungs. As severely ill COVID-19 patients often need to be intubated, a better knowledge of the composition of ET biofilms in this population is important. Read More

Microb Pathog 2022 Jun 16;169:105639. Epub 2022 Jun 16.

Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran; Department of Parasitology and Mycology, Jahrom University of Medical Sciences, Jahrom, Iran. Electronic address:

The gut microbiota consists a diverse and complex ecosystem that is involved in beneficial functions as well as potentially harmful conditions for human. Blastocystis sp. is a common parasite of the digestive tract of animals and humans; however, limited data is available concerning the association of asymptomatic Blastocystis infection and gut bacteria composition. Read More

Mol Biol Rep 2022 Jun 18. Epub 2022 Jun 18.

Antimicrobial Resistance Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Streptogramins and linezolid are important in the treatment of infections caused by vancomycin-resistant enterococci.

Purpose: Then, we aimed to evaluate the resistance rates against these drugs and the prevalence of genes involved in hospital environmental and fecal normal-flora isolates of Enterococcus faecalis and Enterococcus faecium.

Methods And Results: The strains were isolated from the stool samples and hospital environments by culturing on M-Enterococcus (ME) agar, and identified by phenotypic and genotypic microbiological tests. Read More

Pol J Microbiol 2022 Jun 19;71(2):263-277. Epub 2022 Jun 19.

Department of Anesthesiology and Intensive Therapy, Military Institute of Aviation Medicine, Warsaw, Poland.

Hospital-acquired bloodstream infections are a severe worldwide problem associated with significant morbidity and mortality. This retrospective, single-center study aimed to analyze bloodstream infections in patients hospitalized in the intensive care unit of the Military Institute of Medicine, Poland. Data from the years 2007-2019 were analyzed. Read More