6,114 results match your criteria Enterobacter Infections


Broad-Spectrum Cephalosporin-Resistant and/or Fluoroquinolone-Resistant Associated with Canine and Feline Urogenital Infections.

Antibiotics (Basel) 2020 Jul 7;9(7). Epub 2020 Jul 7.

Institute of Microbiology, University of Veterinary Medicine, 1210 Vienna, Austria.

The aim of the present study was to characterize resistant to 3rd and 4th generation cephalosporins, carbapenems and/or fluoroquinolones, isolated from dogs and cats with urogenital infections. In total, 36 strains ( ( = 28), ( = 3), , , , and (each = 1)) were included in the present study, 28 from Austria and 8 from Serbia. Isolates were characterized by a polyphasic approach including susceptibility pheno- and genotyping and microarray-based assays. Read More

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http://dx.doi.org/10.3390/antibiotics9070387DOI Listing

Efficacy of experimental phage therapies in livestock.

Anim Health Res Rev 2020 Jun 19:1-15. Epub 2020 Jun 19.

Sub-Department of Veterinary Prevention and Avian Diseases, Institute of Biological Basis of Animal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland.

Bacteriophages are the most abundant form of life on earth and are present everywhere. The total number of bacteriophages has been estimated to be 1032 virions. The main division of bacteriophages is based on the type of nucleic acid (DNA or RNA) and on the structure of the capsid. Read More

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http://dx.doi.org/10.1017/S1466252319000161DOI Listing

Bacterial associated urinary tract infection, risk factors, and drug susceptibility profile among adult people living with HIV at Haswassa University Comprehensive Specialized Hospital, Hawassa, Southern Esthiopia.

Sci Rep 2020 Jul 1;10(1):10790. Epub 2020 Jul 1.

School of Medical Laboratory Science, Hawassa University College of Medicine and Health Sciences, Awassa, Ethiopia.

People living with human immunodeficiency virus (HIV) are more likely to develop urinary tract infections (UTI) due to the suppression of their immunity. The aim of this study was to determine the prevalence, risk factors of UTI, and drug susceptibility pattern of bacteria isolated among peoples infected with HIV. A hospital-based cross-sectional study was conducted among 224 HIV positive individuals attending Hawassa University Comprehensive Specialized Hospital (HUCSH) from September 17 to November 16, 2018. Read More

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http://dx.doi.org/10.1038/s41598-020-67840-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330024PMC

Recent advances in tackling microbial multidrug resistance with essential oils: combinatorial and nano-based strategies.

Crit Rev Microbiol 2020 Jul 1:1-20. Epub 2020 Jul 1.

Department of Pharmacognosy, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania.

The emergence of multidrug resistant pathogens is a great challenge to the medical field and a major global health threat requiring novel therapeutic strategies. Among plant products, essential oils have significant antimicrobial properties that make them promising agents in the fight against drug resistant human pathogens. The aim of the present review was to highlight the most important essential oil-based antimicrobial strategies as revealed by recent studies. Read More

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http://dx.doi.org/10.1080/1040841X.2020.1782339DOI Listing

Neonatal septicemia at intensive care unit, Ayder Comprehensive Specialized Hospital, Tigray, North Ethiopia: Bacteriological profile, drug susceptibility pattern, and associated factors.

PLoS One 2020 30;15(6):e0235391. Epub 2020 Jun 30.

Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, College of Health Sciences, Mekelle University, Mekelle, Tigray Region, Ethiopia.

Background: Neonatal septicemia is a life threatening medical emergency that requires timely detection of pathogens with urgent rational antibiotics therapy.

Methods: A cross-sectional study was conducted between March 2017 to September 2018 among 317 septicemia suspected neonates at neonatal intensive care unit, Ayder Comprehensive Specialized Hospital, Mekelle, Tigray, North Ethiopia. A 3 mL of blood was collected from each participant. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235391PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326223PMC

Molecular tracking of pathogens in central venous catheter.

J Vasc Access 2020 Jun 26:1129729820934354. Epub 2020 Jun 26.

Department of Social and Preventive Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Background: Central venous catheter-related bloodstream infection is an important adverse event in health care. Molecular methods are not yet substitutive of microbiological in the detection of the pathogens responsible for the infection, but they can help in the epidemiological characterization.

Aim: To detect bacteria by polymerase chain reaction, from material extracted from the tip of central catheters of patients suspected of infection at the intensive care unit. Read More

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http://dx.doi.org/10.1177/1129729820934354DOI Listing

Antibacterial potential of Forsythia suspensa polysaccharide against resistant Enterobacter cloacae with SHV-12 extended-spectrum β-lactamase (ESBL).

J Cell Mol Med 2020 Jun 25. Epub 2020 Jun 25.

Laboratory of Pathogenic Biology, Guangdong Medical University, Zhanjiang, China.

In this study, a homogenous polysaccharide (FSP), with an average molecular weight of 9.08 × 10  Da, was isolated from Forsythia suspense and its antibacterial potential against Enterobacter cloacae producing SHV-12 ESBL was investigated. Growth kinetics, in vitro competition and biofilm formation experiments demonstrated that SHV-12 ESBL contributed to a fitness benefit to E cloacae strain. Read More

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http://dx.doi.org/10.1111/jcmm.15510DOI Listing

Prevalence of Aminoglycoside Resistance Genes and Molecular Characterization of a Novel Gene among Clinical Isolates of Complex from a Chinese Teaching Hospital.

Antimicrob Agents Chemother 2020 Jun 22. Epub 2020 Jun 22.

Key Laboratory of Medical Genetics of Zhejiang Province, Key Laboratory of Laboratory Medicine, Ministry of Education, China, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China

complex are important opportunistic human pathogens capable of causing a wide variety of infections. During recent decades, the aminoglycoside-resistant complex isolates have increasingly been reported and become a major concern. Here we employed high-throughput sequencing in combination with specific PCR assays to investigate the prevalence of aminoglycoside resistance genes among 170 isolates of the complex collected from a teaching hospital in Wenzhou, China. Read More

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http://dx.doi.org/10.1128/AAC.00852-20DOI Listing

Pharmacodynamics of Fosfomycin Against Carbapenem-resistant .

Antimicrob Agents Chemother 2020 Jun 22. Epub 2020 Jun 22.

Department of Pharmacy, Department of Microbiology, Department of Infectious DiseasesSingapore General Hopsital, Singapore; Outram Road, Singapore 169608

The increase of carbapenem-resistant Enterobacterales (CRE) and lack of therapeutic options due to scarcity of new antibiotics has sparked interest towards the use of intravenous fosfomycin against systemic CRE infections. We aimed to investigate the pharmacodynamics of fosfomycin against carbapenem-resistant and Time-kill studies and population analysis profiles were performed with eight clinical CRE isolates, which were exposed to fosfomycin concentrations ranging from 0.25 to 2048mg/L. Read More

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http://dx.doi.org/10.1128/AAC.00536-20DOI Listing

Bacterial spectrum and antibiotic resistance of urinary tract infections in patients treated for upper urinary tract calculi: a multicenter analysis.

Eur J Clin Microbiol Infect Dis 2020 Jun 16. Epub 2020 Jun 16.

Urology School, University of Milan, Milan, Italy.

The purpose of this study is to collect information on the bacterial resistance to antibiotics of bacteria isolated from urine cultures of patients treated for upper urinary tract calculi. Data of patients with urinary tract infection and urolithiasis were retrospectively reviewed to collect information on age, gender, stone size, location, hydronephrosis, procedure of stone removal and antibiotic treatment, identification and susceptibility of pathogens, symptoms, and infectious complications. A total of 912 patients from 11 centers in 7 countries (Bulgaria, Greece, Italy, North Macedonia, Spain, and Turkey) were studied. Read More

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http://dx.doi.org/10.1007/s10096-020-03947-zDOI Listing

Molecular Characteristics of Carbapenem-Resistant in a Tertiary Hospital in China.

Infect Drug Resist 2020 28;13:1575-1581. Epub 2020 May 28.

Department of Respiratory Medicine, Yanbian University Hospital, Yanji, People's Republic of China.

Background: Infections caused by the carbapenem-resistant (CREC) bring great challenges to the clinical treatment and pose a serious threat to public health. In this study, we investigated the molecular characteristics of CREC in a tertiary hospital.

Materials And Methods: A total of 12 non-duplicate CREC strains isolated during the period of November 2016 to July 2019 were subjected to automated microbial identification and antimicrobial susceptibility testing (AST) using the BD Phoenix-100 identification and antimicrobial susceptibility testing (ID/AST) system. Read More

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http://dx.doi.org/10.2147/IDR.S254056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266308PMC

A Systematic Review on Drug Resistant Urinary Tract Infection Among Pregnant Women in Developing Countries in Africa and Asia; 2005-2016.

Infect Drug Resist 2020 18;13:1465-1477. Epub 2020 May 18.

Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, School of Medicine, College of Health Sciences, Mekelle University, Mekelle, 1871, Ethiopia.

Background: Urinary tract infection is one of the most common health problems during pregnancy. It is most commonly reported among pregnant women and is a known reason of morbidity during pregnancy worldwide, predominantly in developing countries. The etiological agents include and others. Read More

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http://dx.doi.org/10.2147/IDR.S250654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245001PMC

In Vitro Activity of Imipenem/Relebactam Against Gram-Negative Bacilli from Pediatric Patients-Study for Monitoring Antimicrobial Resistance Trends (SMART) global surveillance program 2015-2017.

J Pediatric Infect Dis Soc 2020 Jun 14. Epub 2020 Jun 14.

Department of Scientific Affairs, International Health Management Associates, Inc, Schaumburg, Illinois, USA.

Background: Studies describing the activity of imipenem/relebactam against gram-negative bacilli (GNB) isolated from pediatric patients are lacking in the peer-reviewed literature. We address this deficiency by reporting on GNB tested against imipenem/relebactam as part of the Study for Monitoring Antimicrobial Resistance Trends global surveillance program.

Methods: In 2015-2017, 221 laboratories in 59 countries collected 9149 consecutive, aerobic or facultative GNB from pediatric patients (age <18 years) and 100 785 from adult patients with intraabdominal, respiratory, and urinary tract infections. Read More

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http://dx.doi.org/10.1093/jpids/piaa056DOI Listing

Prediction of Antimicrobial Resistance in Gram-Negative Bacteria From Whole-Genome Sequencing Data.

Front Microbiol 2020 25;11:1013. Epub 2020 May 25.

Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Background: Early detection of antimicrobial resistance in pathogens and prescription of more effective antibiotics is a fast-emerging need in clinical practice. High-throughput sequencing technology, such as whole genome sequencing (WGS), may have the capacity to rapidly guide the clinical decision-making process. The prediction of antimicrobial resistance in Gram-negative bacteria, often the cause of serious systemic infections, is more challenging as genotype-to-phenotype (drug resistance) relationship is more complex than for most Gram-positive organisms. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262952PMC

Lascufloxacin hydrochloride to treat bacterial infection.

Drugs Today (Barc) 2020 Jun;56(6):365-376

Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.

Lascufloxacin hydrochloride (AM-1977) is a novel 8-methoxy fluoroquinolone antibacterial agent with a unique pharmacophore at the 1st and 7th positions of the quinoline nucleus developed by Kyorin Pharmaceutical Co., Ltd. (Tokyo, Japan). Read More

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http://dx.doi.org/10.1358/dot.2020.56.6.3137167DOI Listing

Multicenter Evaluation of the Xpert® Carba-R Assay for Detection and Identification of Carbapenemase Genes in Sputum Specimens.

J Clin Microbiol 2020 Jun 10. Epub 2020 Jun 10.

China Aviation General Hospital of China Medical University, Beijing 100012, China.

Rapid diagnosis of infections caused by carbapenem-resistant Enterobacteriaceae (CRE) is crucial for proper treatment and infection control. The Xpert® Carba-R assay is a qualitative multiplex real-time PCR method that qualitatively detects and differentiates five common carbapenemase genes (, , , , and ) directly from rectal swabs or purified colonies within an approximately one hour. We performed a multicenter evaluation of the investigational use of the Carba-R assay for detection and differentiation of carbapenemase genes from sputum specimens in patients with a clinical diagnosis of pneumonia. Read More

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http://dx.doi.org/10.1128/JCM.00644-20DOI Listing

Intraoperative Tobramycin Powder Prevents Enterobacter cloacae Surgical Site Infections in a Rabbit Model of Internal Fixation.

J Orthop Trauma 2020 Jun 3. Epub 2020 Jun 3.

Department of Molecular Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD.

Objectives: To evaluate the efficacy of intraoperative tobramycin powder in preventing surgical site infection (SSI) and implant colonization with Enterobacter cloacae in a rabbit fixation model. Gram-negative rods, particularly Enterobacter species, comprise an increasing percentage of SSI at our institution.(1) METHODS:: Eighteen New Zealand White rabbits underwent surgical fixation of the left tibia with implantation of a plate and screws. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001859DOI Listing

Genome sequence analysis of a novel Enterobacter cloacae phage, Ec_L1, belonging to the genus Eclunavirus.

Arch Virol 2020 Aug 8;165(8):1929-1932. Epub 2020 Jun 8.

School of Bioengineering, Dalian University of Technology, Dalian, 116024, People's Republic of China.

Phages, viruses targeting bacteria, have potential therapeutic applications in the control of infections with antibiotic-resistant bacteria. In this study, an Enterobacter cloacae phage, Ec_L1, was isolated from sewage sludge samples collected from a hospital. The genome of phage Ec_L1 consists of 51,894 bp with 48. Read More

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http://dx.doi.org/10.1007/s00705-020-04672-wDOI Listing

Oral microbial profile in oral cancer patients before and after radiation therapy in a cancer care center - A prospective study.

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):117-124. Epub 2020 May 8.

Department of Dentistry, BGS Global Institute of Medical Sciences, Bengaluru, Karnataka, India.

Background: Head and neck cancer is the sixth most common cancer reported worldwide. In many cases, the level of aggressiveness of therapy adopted in cancer patients may cause the alteration in oral microbiota; the emergence of potential pathogens may cause opportunistic infections in already immune-compromised individuals leading to increases in morbidity and mortality. Hence, this study was conducted to assess the oral microbial profile in oral cancer patients before and after radiotherapy. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_213_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269272PMC

Etiology, clinical findings and laboratory parameters in neonates with acute bacterial meningitis.

Iran J Microbiol 2020 Apr;12(2):89-97

Department of Midwifery, Faculty of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.

Background And Objectives: Neonatal meningitis is one of the most important and serious neonatal infections with a high mortality and morbidity rate. The present study aimed to investigate the causes, clinical signs, laboratory parameters and mortality rates in newborns with bacterial meningitis.

Materials And Methods: This cross-sectional study was performed on 468 neonates aged 2-28 days admitted to NICU in Ghaem Hospital Mashhad, Iran by available sampling method during 2009-2018. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244827PMC

Co-Occurrence of and in Isolated from a Patient with Bloodstream Infection.

Infect Drug Resist 2020 12;13:1397-1402. Epub 2020 May 12.

Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, People's Republic of China.

Background: Bloodstream infection (BSI) caused by carbapenem-resistant Enterobacteriaceae are potentially life-threatening related to poorer outcomes. Colistin is considered one of the last-resort treatments against human infections caused by multidrug-resistant (MDR) Gram-negative bacteria. Therefore, emergence of strains from the blood that co-harboring and carbapenem resistance genes were considered as a serious problem. Read More

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http://dx.doi.org/10.2147/IDR.S248342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229791PMC

Evaluation of Resistance Mechanisms in Carbapenem-Resistant .

Infect Drug Resist 2020 12;13:1377-1385. Epub 2020 May 12.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Carbapenem-resistant (CRE) is a major concern leading to morbidity and mortality in the world. CRE often is becoming a cause of therapeutic failure in both hospital and community-acquired infections.

Aim: This study aimed to investigate the resistance mechanisms of CRE by phenotypic and molecular methods. Read More

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http://dx.doi.org/10.2147/IDR.S244357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229782PMC

Newly-named (formerly ) is Associated with Poor Clinical Outcomes Relative to other Species in Patients with Bloodstream Infection.

J Clin Microbiol 2020 Jun 3. Epub 2020 Jun 3.

Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.

was recently renamed This study aimed to identify differences in clinical characteristics, outcomes, and bacterial genetics among patients with versus species bloodstream infections (BSI). We prospectively enrolled patients with or complex () BSI from 2002-2015. We performed whole genome sequencing (WGS) and pan-genome analysis on all bacteria. Read More

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http://dx.doi.org/10.1128/JCM.00582-20DOI Listing

Identification of Kosakonia cowanii as a rare cause of acute cholecystitis: case report and review of the literature.

BMC Infect Dis 2020 May 24;20(1):366. Epub 2020 May 24.

Institute for Medical Microbiology, Virology and Hygiene, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Background: Kosakonia cowanii, formerly known as Enterobacter cowanii, is a Gram-negative bacillus belonging to the order Enterobacterales. The species is usually recognized as a plant pathogen and has only anecdotally been encountered as a human pathogen. Here we describe the rare case of a K. Read More

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http://dx.doi.org/10.1186/s12879-020-05084-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245821PMC

Prevalence of Extended-Spectrum Beta-Lactamase-Producing Causing Bloodstream Infections in Cancer Patients from Southwest of Iran.

Infect Drug Resist 2020 6;13:1319-1326. Epub 2020 May 6.

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Introduction: This study aimed to evaluate the frequency rate of extended-spectrum beta-lactamase-producing (ESBL-PE) causing bloodstream infections (BSIs) in cancer patients referred to one of the major referral hospitals in Ahvaz city, southwest Iran.

Materials And Methods: In this study, 1700 blood cultures were collected from 610 cancer patients suspected to have BSI from October 2016 to August 2017 referred to the Shafa cancer hospital, Ahvaz, southwest of Iran. The blood culture bottles were incubated aerobically at 35-37ºC for 24 hours and then sub-cultured on routine microbiology culture media. Read More

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http://dx.doi.org/10.2147/IDR.S254357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212769PMC

Draft Genome Sequence of Enterobacter asburiae UFMG-H9, Isolated from Urine from a Healthy Bovine Heifer (Gyr Breed).

Microbiol Resour Announc 2020 May 21;9(21). Epub 2020 May 21.

Bioinformatics Program, Loyola University Chicago, Chicago, Illinois, USA

is part of the complex, related to nosocomial opportunistic infections in humans. Here, we report the draft genome of strain UFMG-H9, an isolate from urine from a healthy Gyr heifer. Read More

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http://dx.doi.org/10.1128/MRA.00385-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242673PMC

Emergence of in Extended-Spectrum-β-Lactamase-Producing Clinical in Pretoria, South Africa: Global Evolutionary Phylogenomics, Resistome, and Mobilome.

mSystems 2020 May 19;5(3). Epub 2020 May 19.

Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Extended-spectrum-β-lactamase (ESBL)-producing are critical-priority pathogens that cause substantial fatalities. With the emergence of mobile genes mediating resistance to colistin in , clinicians are now left with few therapeutic options. Eleven clinical strains with resistance to cephems and/or colistin were genomically analyzed to determine their resistomes, mobilomes, and evolutionary relationships to global strains. Read More

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http://dx.doi.org/10.1128/mSystems.00148-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253365PMC

Efficacy of ceftazidime-avibactam plus aztreonam in patients with bloodstream infections caused by MBL- producing Enterobacterales.

Clin Infect Dis 2020 May 19. Epub 2020 May 19.

Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana. University of Pisa, Italy.

Background: In vitro data support the use of combination of aztreonam (ATM) with ceftazidime-avibactam (CAZ-AVI), but clinical studies are lacking. The aim of our study was to compare the outcome of patients with bloodstream infections (BSIs) due to MBLs-producing Enterobacterales treated either with CAZ-AVI plus ATM or other active antibiotics (OAAs).

Methods: Prospective observational study including patients admitted to three hospitals in Italy and Greece. Read More

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http://dx.doi.org/10.1093/cid/ciaa586DOI Listing

Multicenter, Observational Cohort Study Evaluating Third-Generation Cephalosporin Therapy for Bloodstream Infections Secondary to , , and Species.

Antibiotics (Basel) 2020 May 14;9(5). Epub 2020 May 14.

Department of Clinical Pharmacy and Outcomes Sciences, University of South Carolina College of Pharmacy, Columbia, SC 29208, USA.

Objectives: There is debate on whether the use of third-generation cephalosporins (3GC) increases the risk of clinical failure in bloodstream infections (BSIs) caused by chromosomally-mediated AmpC-producing Enterobacterales (CAE). This study evaluates the impact of definitive 3GC therapy versus other antibiotics on clinical outcomes in BSIs due to Enterobacter, Serratia, or Citrobacter species.

Methods: This multicenter, retrospective cohort study evaluated adult hospitalized patients with BSIs secondary to Enterobacter, Serratia, or Citrobacter species from 1 January 2006 to 1 September 2014. Read More

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http://dx.doi.org/10.3390/antibiotics9050254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277875PMC

Molecular epidemiology of antimicrobial resistant microorganisms in the 21th century: a review of the literature.

Acta Biomed 2020 May 11;91(2):256-273. Epub 2020 May 11.

Array.

Healthcare-associated infections (HAIs) are the most frequent and severe complication acquired in healthcare settings with high impact in terms of morbidity, mortality and costs. Many bacteria could be implicated in these infections, but, expecially multidrug resistance bacteria could play an important role. Many microbial typing technologies have been developed until to the the bacterial whole-genome sequencing and the choice of a molecular typing method therefore will depend on the skill level and resources of the laboratory and the aim and scale of the investigation. Read More

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http://dx.doi.org/10.23750/abm.v91i2.9176DOI Listing

Genetic Characterization of the O-Antigen and Development of a Molecular Serotyping Scheme for .

Front Microbiol 2020 28;11:727. Epub 2020 Apr 28.

Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, China.

is a well-characterized opportunistic pathogen that is closely associated with various nosocomial infections. The O-antigen, which is one of the most variable constituents on the cell surface, has been used widely and traditionally for serological classification of many gram-negative bacteria. is divided into 30 serotypes, based on its O-antigen diversity. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198725PMC

Validation of a Worst-Case Scenario Method Adapted to the Healthcare Environment for Testing the Antibacterial Effect of Brass Surfaces and Implementation on Hospital Antibiotic-Resistant Strains.

Antibiotics (Basel) 2020 May 12;9(5). Epub 2020 May 12.

Laboratoire AGIR - UR UPJV 4294, UFR de Pharmacie, Université de Picardie Jules Verne, 80037 Amiens, France.

The evaluation of antibacterial activity of metal surfaces can be carried out using various published guidelines which do not always agree with each other on technical conditions and result interpretation. Moreover, these technical conditions are sometimes remote from real-life ones, especially those found in health-care facilities, and do not include a variety of antibiotic-resistant strains. A worst-case scenario protocol adapted from published guidelines was validated on two reference strains ( ATCC 6538 and ATCC 13048). Read More

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http://dx.doi.org/10.3390/antibiotics9050245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277655PMC

Trends in Distribution and Antibiotic Resistance of Bacteria Isolated from Urine Cultures of Children in Northern Israel Between 2010 and 2017.

Microb Drug Resist 2020 May 14. Epub 2020 May 14.

The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

To identify the changing trends of uropathogens over the years 2010-2017 and examine the incidence of both antibiotic resistance and extended spectrum beta lactamases (ESBL)-producing Enterobacteriaceae in urine cultures from pediatric patients. Electronic medical records of 1,056 children, admitted to the Poriya Medical Center in Israel, between 2010 and 2017 with positive urine cultures, were reviewed for bacterial species and antibiotics resistance. The leading pathogen was (76%), followed by (7%), (5. Read More

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http://dx.doi.org/10.1089/mdr.2020.0111DOI Listing

Six-year study on peripheral venous catheter-associated BSI rates in 262 ICUs in eight countries of South-East Asia: International Nosocomial Infection Control Consortium findings.

J Vasc Access 2020 May 14:1129729820917259. Epub 2020 May 14.

Cho Ray Hospital, Ho Chi Minh City, Vietnam.

Background: Short-term peripheral venous catheter-associated bloodstream infection rates have not been systematically studied in Asian countries, and data on peripheral venous catheter-associated bloodstream infections incidence by number of short-term peripheral venous catheter days are not available.

Methods: Prospective, surveillance study on peripheral venous catheter-associated bloodstream infections conducted from 1 September 2013 to 31 May 2019 in 262 intensive care units, members of the International Nosocomial Infection Control Consortium, from 78 hospitals in 32 cities of 8 countries in the South-East Asia Region: China, India, Malaysia, Mongolia, Nepal, Philippines, Thailand, and Vietnam. For this research, we applied definition and criteria of the CDC NHSN, methodology of the INICC, and software named INICC Surveillance Online System. Read More

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http://dx.doi.org/10.1177/1129729820917259DOI Listing
May 2020
1.017 Impact Factor

Antimicrobial Resistance in ESKAPE Pathogens.

Clin Microbiol Rev 2020 Jun 13;33(3). Epub 2020 May 13.

School of Chemistry and Molecular Biosciences, The University of Queensland, QLD, Australia

SUMMARYAntimicrobial-resistant ESKAPE ( , , , , , and species) pathogens represent a global threat to human health. The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due to treatment failure and requires a coordinated global response for antimicrobial resistance surveillance. This looming health threat has restimulated interest in the development of new antimicrobial therapies, has demanded the need for better patient care, and has facilitated heightened governance over stewardship practices. Read More

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http://dx.doi.org/10.1128/CMR.00181-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227449PMC

Postpartum mastitis in the breastfeeding women and antimicrobial resistance of responsible pathogens in ukraine: results a multicenter study.

Wiad Lek 2020 ;73(5):895-903

Brovarska Multidisciplinary District Hospital, Brovary, Ukraine.

Objective: The aim: To obtain the prevalence of mastitis in the breastfeeding women and antimicrobial resistance of responsible pathogens in Ukraine.

Patients And Methods: Materials and methods: A retrospective multicenter cohort study was based on surveillance data for Postpartum Mastitis and included 18,427 breastfeeding women's who gave birth in 11 regional hospitals of Ukraine.

Results: Results: 22. Read More

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January 2020

Plasmid-mediated antibiotic resistance among uropathogens in primigravid women-Hyderabad, India.

PLoS One 2020 8;15(5):e0232710. Epub 2020 May 8.

Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Palo Alto, California, United States of America.

With the growing threat of antimicrobial resistance worldwide, uncovering the molecular epidemiology is critical for understanding what is driving this crisis. We aimed to evaluate the prevalence of plasmid-mediated-quinolone-resistance (PMQR) and extended-spectrum beta-lactamase- (ESBL) producing gram-negative organisms among primigravid women with bacteriuria. We collected urine specimens from primigravid women attending their first antenatal visit at Gandhi Hospital during October 1, 2015 to September 30, 2016. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232710PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209122PMC
May 2020
3.234 Impact Factor

Prevalence of Asymptomatic Bacteriuria and Antibiotic Susceptibility Patterns of Bacterial Isolates among Cancer Patients and Healthy Blood Donors at the University of Gondar Specialized Hospital.

Int J Microbiol 2020 16;2020:3091564. Epub 2020 Apr 16.

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, University of Gondar, Gondar, Ethiopia.

Background: Urinary tract infections are the common types of infections in the community and health care settings. Despite the widespread availability of antibiotics, urinary tract infection remains a worldwide therapeutic problem. It is a continuous and significant problem in cancer patients. Read More

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http://dx.doi.org/10.1155/2020/3091564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183528PMC

Urinary Tract Infections among Indonesian Pregnant Women and Its Susceptibility Pattern.

Infect Dis Obstet Gynecol 2020 21;2020:9681632. Epub 2020 Apr 21.

Faculty of Medicine Universitas Indonesia, Indonesia.

Pregnant women are usually at risk of urinary tract infections (UTIs) such as asymptomatic bacteriuria. In the current multidrug-resistance era, appropriate diagnosis and treatment should be provided to avoid complications in pregnant women in developing countries, which have limited facilities, such as Indonesia. The aim of this study was to evaluate in vitro susceptibility tests. Read More

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http://dx.doi.org/10.1155/2020/9681632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191430PMC

Diversity of navel microbiome in young adults.

J Med Microbiol 2020 May 5;69(5):721-727. Epub 2020 May 5.

College of the Sciences and Mathematics, West Chester University, West Chester, PA, USA.

Human skin microbial communities represent a tremendous source of genetic diversity that evolves as a function of human age. Microbiota differs between regions of oily and moist skin, and appears to stabilize with age. We have a minimal understanding of the time frame required for the stabilization of skin microbiota, and the role played by gender. Read More

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http://dx.doi.org/10.1099/jmm.0.001192DOI Listing

IncN3 and IncHI2 plasmids with an In1763 integron carrying in carbapenem-resistant clinical isolates from the UK.

J Med Microbiol 2020 May 5;69(5):739-747. Epub 2020 May 5.

Specialist Antimicrobial and Chemotherapy Unit, Public Health Wales, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK.

Imipenemase (IMP) carbapenemase genes are relatively rare among in the UK. Emergence in multiple hospitals, in different strains and species, prompted an investigation into their genetic context. Our goal was to identify and describe the elements carrying genes in a variety of from five hospitals in the UK. Read More

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http://dx.doi.org/10.1099/jmm.0.001193DOI Listing

Increased Azithromycin Susceptibility of Multidrug-Resistant Gram-Negative Bacteria on RPMI-1640 Agar Assessed by Disk Diffusion Testing.

Antibiotics (Basel) 2020 Apr 29;9(5). Epub 2020 Apr 29.

Department of Infectious Diseases and Hospital Epidemiology, University of Zurich, 8091 Zurich, Switzerland.

Increasing antibiotic resistances and a lack of new antibiotics render the treatment of Gram-negative bacterial infections increasingly difficult. Therefore, additional approaches are being investigated. Macrolides are not routinely used against Gram-negative bacteria due to lack of evidence of in vitro effectiveness. Read More

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http://dx.doi.org/10.3390/antibiotics9050218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277395PMC

Dynamics of colonization in patients with health care-associated infections at step-down care units from a tertiary care hospital in Mexico.

Am J Infect Control 2020 Apr 28. Epub 2020 Apr 28.

Hospital Universitario 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.. Electronic address:

Background: Patient colonization has been suggested as a risk factor in hospital-associated infections (HAI) development, which are of the most frequent complications in hospitals.

Objective: To examine the colonization process and possible transmission routes of HAI-causative agents in step-down care unit (SDCU) patients.

Methods: Patients admitted to SDCU within 48 hours of admission that had no evidence of infection present, nurse health care workers (HCWs), and relatives of infected patients were included. Read More

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http://dx.doi.org/10.1016/j.ajic.2020.04.016DOI Listing

Alternatives for the treatment of infections caused by ESKAPE pathogens.

J Clin Pharm Ther 2020 Aug 27;45(4):863-873. Epub 2020 Apr 27.

Department of Clinical and Toxicological Analysis, Federal University of Santa Maria, Santa Maria, Brazil.

What Is Known And Objective: The widespread use of antibiotics as therapeutic agents caused an increase of multidrug resistant bacteria (MDR) appearance. Regarding MDRs, we highlight the Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.. Read More

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http://dx.doi.org/10.1111/jcpt.13149DOI Listing

Emergence of carbapenem-resistant and colistin-susceptible Enterobacter cloacae complex co-harboring bla and mcr-9 in Japan.

BMC Infect Dis 2020 Apr 16;20(1):282. Epub 2020 Apr 16.

Department of Microbiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: The spread of Enterobacteriaceae producing both carbapenemases and Mcr, encoded by plasmid-mediated colistin resistance genes, has become a serious public health problem worldwide. This study describes three clinical isolates of Enterobacter cloacae complex co-harboring bla and mcr-9 that were resistant to carbapenem but susceptible to colistin.

Methods: Thirty-two clinical isolates of E. Read More

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http://dx.doi.org/10.1186/s12879-020-05021-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161257PMC

Six-year multicenter study on short-term peripheral venous catheters-related bloodstream infection rates in 246 intensive units of 83 hospitals in 52 cities of 14 countries of Middle East: Bahrain, Egypt, Iran, Jordan, Kingdom of Saudi Arabia, Kuwait, Lebanon, Morocco, Pakistan, Palestine, Sudan, Tunisia, Turkey, and United Arab Emirates-International Nosocomial Infection Control Consortium (INICC) findings.

J Infect Public Health 2020 Apr 12. Epub 2020 Apr 12.

Ondokuz Mayis University Medical School, Samsun, Turkey.

Background: Short-term peripheral venous catheters-related bloodstream infections (PVCR-BSIs) rates have not been systematically studied, and data on their incidence by number of device-days is not available.

Methods: Prospective, surveillance study on PVCR-BSI conducted from September 1st, 2013 to 31st Mays, 2019 in 246 intensive care units (ICUs), members of the International Nosocomial Infection Control Consortium (INICC), from 83 hospitals in 52 cities of 14 countries in the Middle East (Bahrain, Egypt, Iran, Jordan, Kingdom of Saudi Arabia, Kuwait, Lebanon, Morocco, Pakistan, Palestine, Sudan, Tunisia, Turkey, and United Arab Emirates). We applied U. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.03.012DOI Listing

Routine Bile Culture From Liver Donors as Screening of Donor-Transmitted Infections in Liver Transplantation.

Liver Transpl 2020 Apr 14. Epub 2020 Apr 14.

Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Bacterial infections are an important threat in the early post-liver transplantation period. Donor-transmitted infections, although rare, can have high mortality. The utility of routine culture from the donor bile duct as screening of donor-transmitted infection has not been evaluated. Read More

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http://dx.doi.org/10.1002/lt.25778DOI Listing

Whole genome sequencing of extended-spectrum β-lactamase genes in Enterobacteriaceae isolates from Nigeria.

PLoS One 2020 14;15(4):e0231146. Epub 2020 Apr 14.

Institute of Medical Microbiology and Hygiene, Austrian Agency for Health and Food Safety (AGES), Vienna, Austria.

Extended Spectrum β-lactamase (ESBL)-producing Enterobacteriaceae are of major concern as they are implicated in multidrug resistant nosocomial infections. They are listed on a recently published global priority list of antibiotic-resistant bacteria by the World Health Organization which raises concern in both healthcare and community settings. This study aimed at determining the frequency of ESBL genes in multidrug resistant human clinical Enterobacteriaceae isolates from Edo state Nigeria and to characterize the resistance mechanisms using whole genome sequencing. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231146PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156064PMC