19,372 results match your criteria Enfermedades Infecciosas y MicrobiologA­a[Journal]


Failure-free survival of the Riata implantable cardioverter-defibrillator lead after a very long-term follow-up.

Indian Pacing Electrophysiol J 2019 Feb 19. Epub 2019 Feb 19.

Arrhythmia Section, Cardiovascular Clinic Institute, Hospital Clínic, University of Barcelona, Catalonia, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Electronic address:

Aims: Riata implantable cardioverter-defibrillator (ICD) leads from St. Jude Medical are prone to malfunction. This study aimed to describe the rate of this lead's malfunction in a very long-term follow-up. Read More

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http://dx.doi.org/10.1016/j.ipej.2019.02.005DOI Listing
February 2019

Omentin protects H9c2 cells against docetaxel cardiotoxicity.

PLoS One 2019 22;14(2):e0212782. Epub 2019 Feb 22.

Cardiology Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela and Health Research Institute, University Clinical Hospital of Santiago de Compostela-Santiago de Compostela, Spain.

Background: Association between obesity and cardiovascular diseases is well known, however increased susceptibility of obese patients to develop several cancer types is not so commonly known. Current data suggest that poorer overall survival in cancer patients might be associated to non-cancer-related causes such as higher risk of cardiotoxicity in obese patients treated with chemotherapeutic agents. Omentin, a novel adipokine decreased in obesity, is actually in the spotlight due to its favourable effects on inflammation, glucose homeostasis and cardiovascular diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212782PLOS
February 2019

Absence of pathogenic mutations in CD59 in chronic inflammatory demyelinating polyradiculoneuropathy.

PLoS One 2019 22;14(2):e0212647. Epub 2019 Feb 22.

Neuromuscular Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Objective: Mutations in CD59 cause CIDP-like polyneuropathy in children with inherited chronic hemolysis. We hypothesized that mutations in CD59 might be found in a subset of sporadic CIDP patients.

Methods: 35 patients from two centers, fulfilling the EFNS/PNS diagnostic criteria for CIDP were included. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212647PLOS
February 2019

Nanostructured fibrin agarose hydrogel as a novel hemostatic agent.

J Tissue Eng Regen Med 2019 Feb 22. Epub 2019 Feb 22.

Instituto de Investigaciones Biomédicas de Sevilla, IBIS, (HUVR/CSIC/Universidad de Sevilla, Junta de Andalucía), Spain.

Blood loss remains a major concern during surgery and can increase the morbidity of the intervention. The use of topical hemostatic agents to overcome this issue therefore becomes necessary. Fibrin sealants are promising hemostatic agents due to their capacity to promote coagulation, but their effectiveness and applicability need to be improved. Read More

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http://dx.doi.org/10.1002/term.2831DOI Listing
February 2019

spp. Infection Rate and Feeding Patterns of Sand Flies (Diptera: Psychodidae) from a Hyperendemic Cutaneous Leishmaniasis Community in Panamá.

Am J Trop Med Hyg 2019 Feb 18. Epub 2019 Feb 18.

Programa Centroamericano de Maestría en Entomología, Universidad de Panamá, Ciudad de Panamá, Panamá.

American cutaneous leishmaniasis (ACL) is a common and important vector-borne parasitic zoonosis in Panamá. Here, we study spp. infection rates and blood-feeding patterns among common sand flies in Trinidad de Las Minas, a rural community with hyperendemic ACL transmission, and where a deltamethrin fogging trial was performed. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0628DOI Listing
February 2019

Multimorbidities of Pediatric Allergic Rhinitis.

Curr Allergy Asthma Rep 2019 Feb 22;19(2):13. Epub 2019 Feb 22.

INGENIO, Immunoal.lèrgia Respiratòria Clínica i Experimental (IRCE), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.

Purpose Of Review: Most children and adolescents with allergic rhinitis (AR) present extra-nasal multimorbid conditions, including conjunctivitis, asthma, atopic dermatitis, rhinosinusitis, or seromucous otitis. Additionally, they may present nasal obstructive disorders, such as septal deformity, turbinate enlargement, and adenoidal hyperplasia, which worsen nasal symptoms, especially nasal obstruction. This is a narrative review on the current state of the concomitant presence of AR and one or more multimorbidities. Read More

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http://dx.doi.org/10.1007/s11882-019-0843-9DOI Listing
February 2019

Barriers in Latin America for the management of locally advanced breast cancer.

Ecancermedicalscience 2019 22;13:897. Epub 2019 Jan 22.

Departamento de Medicina Oncológica, Oncosalud-AUNA, Lima 15036, Peru.

Breast cancer (BC) is a highly prevalent malignancy in Latin American women, most cases being diagnosed at locally advanced or metastatic stages when options for cancer care are limited. Despite its label as a public health problem in the region, Latin American BC patients face several barriers in accessing standard of care treatment when compared with patients from developed countries. In this review, we analyse the landscape of the four main identified barriers in the region: i) high burden of locally advanced/advanced BC; ii) inadequate access to medical resources; iii) deficient access to specialised cancer care and iv) insufficient BC research in Latin America. Read More

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http://dx.doi.org/10.3332/ecancer.2019.897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372299PMC
January 2019

Precision medicine for locally advanced breast cancer: frontiers and challenges in Latin America.

Ecancermedicalscience 2019 22;13:896. Epub 2019 Jan 22.

Departamento de Medicina Oncológica, Oncosalud-AUNA, Lima 15036, Perú.

Advances in high-throughput technologies and their involvement in the 'omics' of cancer have made possible the identification of hundreds of biomarkers and the development of predictive and prognostic platforms that model the management of cancer from evidence-based medicine to precision medicine. Latin America (LATAM) is a region characterised by fragmented healthcare, high rates of poverty and disparities to access to a basic standard of care not only for cancer but also for other complex diseases. Patients from the public setting cannot afford targeted therapy, the facilities offering genomic platforms are scarce and the use of high-precision radiotherapy is limited to few facilities. Read More

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http://dx.doi.org/10.3332/ecancer.2019.896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372295PMC
January 2019

Role for nuclear interleukin-37 in the suppression of innate immunity.

Proc Natl Acad Sci U S A 2019 Feb 21. Epub 2019 Feb 21.

Department of Medicine, University of Colorado Denver, Aurora, CO 80045;

The IL-1 family member IL-37 broadly suppresses innate inflammation and acquired immunity. Similar to IL-1α and IL-33, IL-37 is a dual-function cytokine in that IL-37 translocates to the nucleus but also transmits a signal via surface membrane receptors. The role of nuclear IL-37 remains unknown on the ability of this cytokine to inhibit innate inflammation. Read More

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http://dx.doi.org/10.1073/pnas.1821111116DOI Listing
February 2019

Exploring the use of metformin in pregnant women with polycystic ovary syndrome: new evidence, new wisdom.

Lancet Diabetes Endocrinol 2019 Feb 18. Epub 2019 Feb 18.

Paediatric and Adolescent Endocrinology, University Hospital Gasthuisberg, Leuven, Belgium; Department of Development and Regeneration, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/S2213-8587(19)30060-9DOI Listing
February 2019

Skin lesion and lymphangitis in an immunocompetent patient.

Enferm Infecc Microbiol Clin 2019 Feb 18. Epub 2019 Feb 18.

Servicio de Microbiología, Hospital Universitario Cruces, Barakaldo, Vizcaya, España.

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http://dx.doi.org/10.1016/j.eimc.2018.12.012DOI Listing
February 2019

Molecular basis and cellular mechanisms of eosinophilic esophagitis for the clinical practice.

Expert Rev Gastroenterol Hepatol 2019 Feb 15;13(2):99-117. Epub 2018 Nov 15.

b Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) , Madrid , Spain.

Introduction: Eosinophilic esophagitis (EoE) is a chronic, allergen-driven inflammatory esophageal disease characterized by predominantly eosinophilic inflammation leading to esophageal dysfunction. Recent efforts to understand EoE have increased our knowledge of the disease. Areas covered: Multiple cells, molecules, and genes interplay with early life environmental factors in the pathophysiology of EoE to converge in the esophageal epithelium at the center of disease pathogenesis. Read More

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http://dx.doi.org/10.1080/17474124.2019.1546120DOI Listing
February 2019

Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives.

Molecules 2019 Feb 20;24(4). Epub 2019 Feb 20.

Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain.

A new series of glycyrrhetinic acid derivatives has been synthesized via the introduction of different heterocyclic rings conjugated with an α,β-unsaturated ketone in its ring A. These new compounds were screened for their antiproliferative activity in a panel of nine human cancer cell lines. Compound was the most active derivative, with an IC of 1. Read More

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http://dx.doi.org/10.3390/molecules24040766DOI Listing
February 2019

A Single-Nucleotide Polymorphism of αβ₃ Integrin Is Associated with the Andes Virus Infection Susceptibility.

Viruses 2019 Feb 20;11(2). Epub 2019 Feb 20.

Departamento de Enfermedades Infecciosas e Inmunologia Pediatricas, División de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.

The (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as "TT" (coding leucine) and "CC" (coding proline), respectively. Read More

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http://dx.doi.org/10.3390/v11020169DOI Listing
February 2019

CRTAM NK cells endowed with suppressor properties arise in leukemic bone marrow.

J Leukoc Biol 2019 Feb 21. Epub 2019 Feb 21.

Unidad de Investigación Médica en Enfermedades Oncológicas, UMAE Hospital Oncología, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Due to their increasing rates of morbidity and mortality, childhood malignancies are considered a global health priority, with acute lymphoblastic leukemias (ALLs) showing the highest incidence worldwide. Control of malignant clone emergence and the subsequent normal-leukemic hematopoietic cell out-competition require antitumor monitoring mechanisms. Investigation of cancer surveillance innate cells may be critical to understand the mechanisms contributing in either disease progression or relapse, and to promote displacement of leukemic hematopoiesis by the normal counterpart. Read More

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http://dx.doi.org/10.1002/JLB.MA0618-231RDOI Listing
February 2019

In utero exposure to bisphenol-A disrupts key elements of retinoid system in male mice offspring.

Food Chem Toxicol 2019 Feb 18. Epub 2019 Feb 18.

Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Elche, Spain.

The retinoid system controls essential cellular processes including mitosis, differentiation and metabolism among others. Although the retinoid-signalling pathway is a potential target for the action of several endocrine disrupting chemicals (EDCs), the information about the developmental effects of bisphenol-A (BPA) on the hepatic retinoid system is scarce. Herein, male mice were in utero exposed to BPA following maternal subcutaneous doses of 0, 10 and 100 μg/kg bw/day from gestational day 9-16 and they were sacrificed at post-natal day 30. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.023DOI Listing
February 2019

Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation.

J Mol Biol 2019 Feb 18. Epub 2019 Feb 18.

Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Buenos Aires, Argentina; CONICET - Universidad de Buenos Aires. Instituto de Química Biológica (IQUIBICEN). Buenos Aires, Argentina; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Fisiología y Biología Molecular y Celular. Buenos Aires, Argentina; Established investigators from the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Electronic address:

Chromatin remodeling is fundamental for the dynamical changes in transcriptional programs that occur during development and stem cell differentiation. The histone acetyltransferase Kat6b is relevant for neurogenesis in mouse embryos and mutations of this gene cause intellectual disability in humans. However, the molecular mechanisms involved in Kat6b mutant phenotype and the role of this chromatin modifier in embryonic stem (ES) cells remain elusive. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.02.012DOI Listing
February 2019

Structural differences in the diaphragm of patients following controlled vs assisted and spontaneous mechanical ventilation.

Intensive Care Med 2019 Feb 21. Epub 2019 Feb 21.

Critical Care Department, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain.

Purpose: Ventilator-induced diaphragm dysfunction or damage (VIDD) is highly prevalent in patients under mechanical ventilation (MV), but its analysis is limited by the difficulty of obtaining histological samples. In this study we compared diaphragm histological characteristics in Maastricht III (MSIII) and brain-dead (BD) organ donors and in control subjects undergoing thoracic surgery (CTL) after a period of either controlled or spontaneous MV (CMV or SMV).

Methods: In this prospective study, biopsies were obtained from diaphragm and quadriceps. Read More

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http://dx.doi.org/10.1007/s00134-019-05566-5DOI Listing
February 2019

Approach to amoebic colitis: Epidemiological, clinical and diagnostic considerations in a non-endemic context (Barcelona, 2007-2017).

PLoS One 2019 21;14(2):e0212791. Epub 2019 Feb 21.

Infectious Disease Department, AIDS Research Institute-IrsiCaixa, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Spain.

Background: Amoebic colitis is the most frequent clinical manifestation of invasive intestinal infection due to Entamoeba histolytica and a common cause of diarrhoea worldwide. Since higher transmission rates are usually related to poor health and exposure to unhygienic conditions, cases reported in Europe usually involve immigrants and international travellers. The goal of this study was to characterise both the clinical and the epidemiological features of a European population diagnosed with amoebic colitis and then to evaluate the diagnostic tools and therapeutic options applied. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212791PLOS
February 2019

Polymorphisms in CYP1A2, CYP2C9 and ABCB1 affect agomelatine pharmacokinetics.

J Psychopharmacol 2019 Feb 21:269881119827959. Epub 2019 Feb 21.

1 Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.

Background:: Agomelatine is an agonist of the melatoninergic receptors used for the treatment of depression. Our aim was to evaluate the effect of genetic polymorphisms in metabolising enzymes and the P-glycoprotein transporter on agomelatine pharmacokinetics and pharmacodynamics.

Methods:: Twenty-eight healthy volunteers receiving a single 25 mg oral dose of agomelatine, were genotyped for nine polymorphisms in cytochrome P450 enzymes ( CYP1A2, CYP2C9 and CYP2C19) and adenosine triphosphate-binding cassette subfamily B member 1 ( ABCB1), by real-time polymerase chain reaction . Read More

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http://dx.doi.org/10.1177/0269881119827959DOI Listing
February 2019

Antimicrobial management of Tropheryma whipplei endocarditis: the Spanish Collaboration on Endocarditis (GAMES) experience.

J Antimicrob Chemother 2019 Feb 20. Epub 2019 Feb 20.

Departamento de Enfermedades Infecciosas, Hospital Universitario San Pedro-Centro de investigación Biomédica de La Rioja (CIBIR), Logroño, Spain.

Objectives: Tropheryma whipplei has been detected in 3.5% of the blood culture-negative cases of endocarditis in Spain. Experience in the management of T. Read More

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http://dx.doi.org/10.1093/jac/dkz059DOI Listing
February 2019

Practical Guide to the Identification and Diagnosis of Asthma-COPD Overlap (ACO).

COPD 2019 Feb 21:1-7. Epub 2019 Feb 21.

a Pneumology Department , University Hospital Vall d'Hebron/Vall d'Hebron Research Institute (VHIR) , Barcelona , Spain.

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality around the world. COPD is characterised by a heterogeneous clinical presentation and prognosis which may vary according to the clinical phenotype. One of the phenotypes of COPD most frequently studied is the asthma-COPD overlap (ACO), however, there are no universally accepted diagnostic criteria for ACO. Read More

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http://dx.doi.org/10.1080/15412555.2019.1575802DOI Listing
February 2019

Differences in the cluster of depressive symptoms between subjects with type 2 diabetes and individuals with a major depressive disorder and without diabetes.

J Endocrinol Invest 2019 Feb 20. Epub 2019 Feb 20.

Endocrinology and Nutrition Department, Hospital Son Llàtzer, University Institute of Health Science Research (IUNICS) and Health Research Institute of Palma (IdISPa), Ctra Manacor km 4, 07198, Palma de Mallorca, Baleares, Spain.

Background: Depressive disorder encompasses a wide spectrum of somatic and psychological symptoms. It is not known whether there are differences regarding the cluster of depressive symptomatology between subjects with depression with and without T2DM.

Purpose: To explore whether the cluster of depression that prevails among depressive subjects with T2DM differs from individuals with depression, but without T2DM. Read More

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http://dx.doi.org/10.1007/s40618-019-01020-xDOI Listing
February 2019

Characterization of digestive disorders of patients with chronic Chagas disease in Cochabamba, Bolivia.

Heliyon 2019 Feb 7;5(2):e01206. Epub 2019 Feb 7.

Fundación CEADES, Cochabamba, Bolivia.

Background: Chagas disease (CD) is endemic in Latin America and particularly common in Bolivia, but there is little information on the characteristics of chronic digestive involvement.

Objectives: To determine the prevalence and characterize digestive manifestations in chronic CD patients in Cochabamba, Bolivia.

Methods: Eighty-five -seropositive individuals with or without digestive symptoms (G1 group), and fifteen -seronegative patients with similar digestive symptoms to those seen in CD (G2 group) were included in the study. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369243PMC
February 2019

Differential Oxygenation in Tumor Microenvironment Modulates Macrophage and Cancer Cell Crosstalk: Novel Experimental Setting and Proof of Concept.

Front Oncol 2019 6;9:43. Epub 2019 Feb 6.

Unitat de Biofísica i Bioenginyeria, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.

Hypoxia is a common characteristic of many solid tumors that has been associated with tumor aggressiveness. Limited diffusion of oxygen generates a gradient of oxygen availability from the blood vessel to the interstitial space and may underlie the recruitment of macrophages fostering cancer progression. However, the available data based on the recruitment of circulating cells to the tumor microenvironment has been so far carried out by conventional co-culture systems which ignore the hypoxic gradient between the vessel to the tumor interstitium. Read More

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http://dx.doi.org/10.3389/fonc.2019.00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373430PMC
February 2019

Differences in the metabolite composition and mechanical properties of extracellular vesicles secreted by hepatic cellular models.

J Extracell Vesicles 2019 11;8(1):1575678. Epub 2019 Feb 11.

Exosomes Laboratory, CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.

Liver constitutes the major metabolic factory in the organism and is involved in the synthesis, secretion and clearance of many blood-circulating molecules. Previously, we have characterised the protein and RNA cargo of extracellular vesicles (EVs) secreted by two hepatic cellular models, a mouse hepatocyte progenitor cell line (MLP29) and primary rat hepatocytes (RHs). Here, we report the metabolome profile of these vesicles by performing a targeted UHPLC-MS metabolomics analysis of these two cellular models and their respective secreted EVs. Read More

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http://dx.doi.org/10.1080/20013078.2019.1575678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374943PMC
February 2019

Whole-Genome Sequences of Five Strains From a Child With Leukemia M2.

Front Microbiol 2019 6;10:132. Epub 2019 Feb 6.

Laboratorio de Investigación en Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.

is an opportunistic pathogen and is one of the primary etiological agents of healthcare-associated infections (HAIs). infections are difficult to treat due to the intrinsic and acquired antibiotic resistance of strains of this bacterium, which frequently limits therapeutic options. In this study, five strains (810CP, 433H, 434H, 483H, and A-2), all of which were isolated from a child with leukemia M2, were characterized through antibiotic susceptibility profiling, the detection of genes encoding carbapenem hydrolyzing oxacillinases, pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), adherence and invasion assays toward the A549 cell line, and the whole-genome sequence (WGS). Read More

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http://dx.doi.org/10.3389/fmicb.2019.00132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372515PMC
February 2019

Distinct Functions for Mammalian CLASP1 and -2 During Neurite and Axon Elongation.

Front Cell Neurosci 2019 29;13. Epub 2019 Jan 29.

Department of Cell Biology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, Netherlands.

Mammalian cytoplasmic linker associated protein 1 and -2 (CLASP1 and -2) are microtubule (MT) plus-end tracking proteins that selectively stabilize MTs at the edge of cells and that promote MT nucleation and growth at the Golgi, thereby sustaining cell polarity. analysis has shown that CLASPs are MT growth promoting factors. To date, a single CLASP1 isoform (called CLASP1α) has been described, whereas three CLASP2 isoforms are known (CLASP2α, -β, and -γ). Read More

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http://dx.doi.org/10.3389/fncel.2019.00005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373834PMC
January 2019

Genome-wide association study of germline variants and breast cancer-specific mortality.

Authors:
Maria Escala-Garcia Qi Guo Thilo Dörk Sander Canisius Renske Keeman Joe Dennis Jonathan Beesley Julie Lecarpentier Manjeet K Bolla Qin Wang Jean Abraham Irene L Andrulis Hoda Anton-Culver Volker Arndt Paul L Auer Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Leslie Bernstein Carl Blomqvist Bram Boeckx Stig E Bojesen Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Hermann Brenner Adam Brentnall Louise Brinton Per Broberg Ian W Brock Sara Y Brucker Barbara Burwinkel Carlos Caldas Trinidad Caldés Daniele Campa Federico Canzian Angel Carracedo Brian D Carter Jose E Castelao Jenny Chang-Claude Stephen J Chanock Georgia Chenevix-Trench Ting-Yuan David Cheng Suet-Feung Chin Christine L Clarke Emilie Cordina-Duverger Fergus J Couch David G Cox Angela Cox Simon S Cross Kamila Czene Mary B Daly Peter Devilee Janet A Dunn Alison M Dunning Lorraine Durcan Miriam Dwek Helena M Earl Arif B Ekici A Heather Eliassen Carolina Ellberg Christoph Engel Mikael Eriksson D Gareth Evans Jonine Figueroa Dieter Flesch-Janys Henrik Flyger Marike Gabrielson Manuela Gago-Dominguez Eva Galle Susan M Gapstur Montserrat García-Closas José A García-Sáenz Mia M Gaudet Angela George Vassilios Georgoulias Graham G Giles Gord Glendon David E Goldgar Anna González-Neira Grethe I Grenaker Alnæs Mervi Grip Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A Haiman Niclas Håkansson Per Hall Ute Hamann Susan Hankinson Elaine F Harkness Patricia A Harrington Steven N Hart Jaana M Hartikainen Alexander Hein Peter Hillemanns Louise Hiller Bernd Holleczek Antoinette Hollestelle Maartje J Hooning Robert N Hoover John L Hopper Anthony Howell Guanmengqian Huang Keith Humphreys David J Hunter Wolfgang Janni Esther M John Michael E Jones Arja Jukkola-Vuorinen Audrey Jung Rudolf Kaaks Maria Kabisch Katarzyna Kaczmarek Michael J Kerin Sofia Khan Elza Khusnutdinova Johanna I Kiiski Cari M Kitahara Julia A Knight Yon-Dschun Ko Linetta B Koppert Veli-Matti Kosma Peter Kraft Vessela N Kristensen Ute Krüger Tabea Kühl Diether Lambrechts Loic Le Marchand Eunjung Lee Flavio Lejbkowicz Lian Li Annika Lindblom Sara Lindström Martha Linet Jolanta Lissowska Wing-Yee Lo Sibylle Loibl Jan Lubiński Michael P Lux Robert J MacInnis Melanie Maierthaler Tom Maishman Enes Makalic Arto Mannermaa Mehdi Manoochehri Siranoush Manoukian Sara Margolin Maria Elena Martinez Dimitrios Mavroudis Catriona McLean Alfons Meindl Pooja Middha Nicola Miller Roger L Milne Fernando Moreno Anna Marie Mulligan Claire Mulot Rami Nassir Susan L Neuhausen William T Newman Sune F Nielsen Børge G Nordestgaard Aaron Norman Håkan Olsson Nick Orr V Shane Pankratz Tjoung-Won Park-Simon Jose I A Perez Clara Pérez-Barrios Paolo Peterlongo Christos Petridis Mila Pinchev Karoliona Prajzendanc Ross Prentice Nadege Presneau Darya Prokofieva Katri Pylkäs Brigitte Rack Paolo Radice Dhanya Ramachandran Gadi Rennert Hedy S Rennert Valerie Rhenius Atocha Romero Rebecca Roylance Emmanouil Saloustros Elinor J Sawyer Daniel F Schmidt Rita K Schmutzler Andreas Schneeweiss Minouk J Schoemaker Fredrick Schumacher Lukas Schwentner Rodney J Scott Christopher Scott Caroline Seynaeve Mitul Shah Jacques Simard Ann Smeets Christof Sohn Melissa C Southey Anthony J Swerdlow Aline Talhouk Rulla M Tamimi William J Tapper Manuel R Teixeira Maria Tengström Mary Beth Terry Kathrin Thöne Rob A E M Tollenaar Ian Tomlinson Diana Torres Thérèse Truong Constance Turman Clare Turnbull Hans-Ulrich Ulmer Michael Untch Celine Vachon Christi J van Asperen Ans M W van den Ouweland Elke M van Veen Camilla Wendt Alice S Whittemore Walter Willett Robert Winqvist Alicja Wolk Xiaohong R Yang Yan Zhang Douglas F Easton Peter A Fasching Heli Nevanlinna Diana M Eccles Paul D P Pharoah Marjanka K Schmidt

Br J Cancer 2019 Feb 21. Epub 2019 Feb 21.

The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands.

Background: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry.

Methods: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Read More

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http://dx.doi.org/10.1038/s41416-019-0393-xDOI Listing
February 2019

Sex differences in the H NMR metabolic profile of serum in cardiovascular risk patients.

Sci Rep 2019 Feb 20;9(1):2380. Epub 2019 Feb 20.

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.

Personalized diagnosis and risk stratification of cardiovascular diseases would allow optimizing therapeutic strategies and lifestyle changes. Metabolomics is a promising technique for personalized diagnosis and prognosis; however, various physiological parameters, including sex, influence the metabolic profile thus hampering its translation to the clinic. Knowledge of the variation in the metabolic profile associated with sex would facilitate metabolomic translation to the clinic. Read More

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http://dx.doi.org/10.1038/s41598-019-38881-4DOI Listing
February 2019

Response to ECG, February 2018.

Rev Esp Cardiol (Engl Ed) 2018 Mar 26;71(3):207. Epub 2018 Feb 26.

Instituto de Ciencias del Corazón (ICICOR), Hospital Clínico Universitario de Valladolid, Valladolid, Spain; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.

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http://dx.doi.org/10.1016/j.rec.2017.10.021DOI Listing

Plasmodium vivax CSP-Pvs25 variants from southern Mexico produce distinct patterns of infectivity for Anopheles albimanus versus An. pseudopunctipennis, in each case independent of geographical origin.

Parasit Vectors 2019 Feb 20;12(1):86. Epub 2019 Feb 20.

Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública, Tapachula, 30700, Chiapas, México.

Background: The susceptibility of Anopheles albimanus and An. pseudopunctipennis to local Plasmodium vivax has been associated in southern Mexico with two ookinete surface proteins (Pvs25/28) polymorphism. Perhaps parasite population selection (i. Read More

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http://dx.doi.org/10.1186/s13071-019-3331-0DOI Listing
February 2019

Genome plasticity favours double chromosomal Tn4401b-bla transposon insertion in the Pseudomonas aeruginosa ST235 clone.

BMC Microbiol 2019 Feb 20;19(1):45. Epub 2019 Feb 20.

Bacterial Molecular Genetics Laboratory, Universidad El Bosque, Carrera 9 N°131A-02, Bogotá D.C, Colombia.

Background: Pseudomonas aeruginosa Sequence Type 235 is a clone that possesses an extraordinary ability to acquire mobile genetic elements and has been associated with the spread of resistance genes, including genes that encode for carbapenemases. Here, we aim to characterize the genetic platforms involved in resistance dissemination in bla-positive P. aeruginosa ST235 in Colombia. Read More

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http://dx.doi.org/10.1186/s12866-019-1418-6DOI Listing
February 2019

Chronic electrical stimulation reduces hyperalgesia and associated spinal changes induced by peripheral nerve injury.

Neuromodulation 2019 Feb 20. Epub 2019 Feb 20.

Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Universitat Autònoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Bellaterra, Spain.

Objectives: We aimed to investigate if different protocols of electrical stimulation following nerve injury might improve neuropathic pain outcomes and modify associated plastic changes at the spinal cord level.

Materials And Methods: Adult rats were subjected to sciatic nerve transection and repair, and distributed in four groups: untreated (SNTR, n = 12), repeated acute electrical stimulation (rAES, 50 Hz, one hour, n = 12), chronic electrical stimulation (CES, 50 Hz, one hour, n = 12), and increasing-frequency chronic electrical stimulation (iCES, one hour, n = 12) delivered during two weeks following the lesion. The threshold of nociceptive withdrawal to mechanical stimuli was evaluated by means of a Von Frey algesimeter during three weeks postlesion. Read More

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http://dx.doi.org/10.1111/ner.12927DOI Listing
February 2019

Association of cardiovascular autonomic dysfunction with peripheral arterial stiffness in patients with type 1 diabetes.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Context: Cardiovascular autonomic (CAN) neuropathy appears to contribute to peripheral arterial stiffness (AS) in type 1 diabetes. If CAN in patients with AS is associated to concomitant asymptomatic atherosclerotic disease (aPAD) remains unclear.

Objective: To assess the risk of CAN in patients with type 1 diabetes and AS and its potential association to atherosclerosis. Read More

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http://dx.doi.org/10.1210/jc.2018-02729DOI Listing
February 2019

FEMALE PATTERN HAIR LOSS AND ANDROGEN EXCESS: A REPORT FROM THE MULTIDISCIPLINARY ANDROGEN EXCESS AND PCOS COMMITTEE.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology and Medicine, Duke University Medical Center, Durham, NC, USA.

Objective: To determine the current state of knowledge and provide evidence-based recommendations that could be valid for all specialists taking care of female pattern hair loss (FPHL), a common form of hair loss in women that is characterized by the reduction of hair density in the central area of the scalp, while the frontal hairline is generally well conserved.

Participants: An expert task force appointed by Androgen Excess and PPCOS society, which included specialists from dermatology, endocrinology, and reproductive endocrinology.

Evidence: Levels of evidence were assessed and graded from A to D. Read More

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http://dx.doi.org/10.1210/jc.2018-02548DOI Listing
February 2019
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Entomological and virological surveillance for dengue virus in churches in Merida, Mexico.

Rev Inst Med Trop Sao Paulo 2019 Feb 14;61:e9. Epub 2019 Feb 14.

Universidad Autónoma de Yucatán, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Laboratorio de Arbovirología, Mérida, Yucatán, México.

This study was designed to assess whether churches in endemic dengue districts in Merida, Mexico provide suitable breeding habitats for mosquitoes and are potential sites for dengue virus (DENV) transmission. Churches were inspected for immature and adult mosquitoes once every week from November 2015 to October 2016. A total of 10,997 immatures of five species were collected. Read More

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http://dx.doi.org/10.1590/S1678-9946201961009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376932PMC
February 2019

Delayed resolution of bleomycin-induced pulmonary fibrosis in absence of MMP13 (collagenase 3).

Am J Physiol Lung Cell Mol Physiol 2019 Feb 20. Epub 2019 Feb 20.

Universidad Nacional Autonoma de Mexico.

MMP13 deficiency in pulmonary fibrosis have described contradictory phenotypes on inflammatory and fibrotic responses after lung injury and its role during lung fibrosis resolution is still undefined. MMP13 has been considered the main collagenase in rodents, and the remodeling of fibrillar collagen is widely attributed to the action of this enzyme. In this study we aimed to explore the role of MMP13 during lung fibrosis progression and resolution. Read More

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http://dx.doi.org/10.1152/ajplung.00455.2017DOI Listing
February 2019

Severe Eosinophilic Allergic Asthma Responsive to Mepolizumab After Failure of 2 Consecutive Biologics.

J Investig Allergol Clin Immunol 2019 Feb;29(1):79-81

Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.

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http://dx.doi.org/10.18176/jiaci.0340DOI Listing
February 2019

Role of Creatine Kinase as an Allergen in Immediate Selective Allergy to Pork Meat.

J Investig Allergol Clin Immunol 2019 Feb;29(1):64-66

Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias, Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.

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http://dx.doi.org/10.18176/jiaci.0333DOI Listing
February 2019

Dilemmas and New Paradigms in Asthma Management.

J Investig Allergol Clin Immunol 2019 Feb;29(1):15-23

Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ) and CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.

Asthma is one of the most common inflammatory diseases in the world. The main goal of treatment is to achieve optimal control. Although every patient is different, clinical practice guidelines can help physicians to manage the disease. Read More

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http://dx.doi.org/10.18176/jiaci.0345DOI Listing
February 2019

Cerebellar resting-state functional connectivity in Parkinson's disease and multiple system atrophy: Characterization of abnormalities and potential for differential diagnosis at the single-patient level.

Neuroimage Clin 2019 Feb 13;22:101720. Epub 2019 Feb 13.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain; Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institute of Neuroscience, University of Barcelona, Barcelona, Catalonia, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain. Electronic address:

Background: Recent studies using resting-state functional connectivity and machine-learning to distinguish patients with neurodegenerative diseases from other groups of subjects show promising results. This approach has not been tested to discriminate between Parkinson's disease (PD) and multiple system atrophy (MSA) patients.

Objectives: Our first aim is to characterize possible abnormalities in resting-state functional connectivity between the cerebellum and a set of intrinsic-connectivity brain networks and between the cerebellum and different regions of the striatum in PD and MSA. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101720DOI Listing
February 2019

Serial Magnetic Resonance Imaging to Identify Early Stages of Anthracycline-Induced Cardiotoxicity.

J Am Coll Cardiol 2019 Feb;73(7):779-791

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain; Cardiology Department, IIS-Fundación Jiménez Díaz Hospital, Madrid, Spain. Electronic address:

Background: Anthracycline-induced cardiotoxicity is a major clinical problem, and early cardiotoxicity markers are needed.

Objectives: The purpose of this study was to identify early doxorubicin-induced cardiotoxicity by serial multiparametric cardiac magnetic resonance (CMR) and its pathological correlates in a large animal model.

Methods: Twenty pigs were included. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.11.046DOI Listing
February 2019

Current mentorship practices in the training of the next generation of clinical microbiology and infectious disease specialists: an international cross-sectional survey.

Eur J Clin Microbiol Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

The purpose of this study was to describe the current practice of mentorship in clinical microbiology (CM) and infectious diseases (ID) training, to identify possible areas for improvement and to assess the factors that are associated with satisfactory mentorship. An international cross-sectional survey containing 35 questions was answered by 317 trainees or specialists who recently completed clinical training. Overall, 179/317 (56%) trainees were satisfied with their mentors, ranging from 7/9 (78%) in non-European countries, 39/53 (74%) in Northern Europe, 13/22 (59%) in Eastern Europe, 61/110 (56%) in Western Europe, 37/76 (49%) in South-Western Europe to 22/47 (47%) in South-Eastern Europe. Read More

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http://dx.doi.org/10.1007/s10096-019-03509-yDOI Listing
February 2019

Inhibiting Human Parainfluenza Virus Infection by Preactivating the Cell Entry Mechanism.

MBio 2019 Feb 19;10(1). Epub 2019 Feb 19.

Department of Pediatrics, Columbia University Medical Center, New York, New York, USA

Paramyxoviruses, specifically, the childhood pathogen human parainfluenza virus type 3, are internalized into host cells following fusion between the viral and target cell membranes. The receptor binding protein, hemagglutinin (HA)-neuraminidase (HN), and the fusion protein (F) facilitate viral fusion and entry into the cell through a coordinated process involving HN activation by receptor binding, which triggers conformational changes in the F protein to activate it to reach its fusion-competent state. Interfering with this process through premature activation of the F protein has been shown to be an effective antiviral strategy Conformational changes in the F protein leading to adoption of the postfusion form of the protein-prior to receptor engagement of HN at the host cell membrane-render the virus noninfectious. Read More

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http://dx.doi.org/10.1128/mBio.02900-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381285PMC
February 2019

Molecular analysis of APOB, SAR1B, ANGPTL3, and MTTP in patients with primary hypocholesterolemia in a clinical laboratory setting: Evidence supporting polygenicity in mutation-negative patients.

Atherosclerosis 2019 Feb 11;283:52-60. Epub 2019 Feb 11.

Hospital de la Santa Creu i Sant Pau, Servei de Bioquímica - IIB Sant Pau, Barcelona, Spain. Electronic address:

Background And Aims: Primary hypobetalipoproteinemia is generally considered a heterogenic group of monogenic, inherited lipoprotein disorders characterized by low concentrations of LDL cholesterol and apolipoprotein B in plasma. Lipoprotein disorders include abetalipoproteinemia, familial hypobetalipoproteinemia, chylomicron retention disease, and familial combined hypolipidemia. Our aim was to review and analyze the results of the molecular analysis of hypolipidemic patients studied in our laboratory over the last 15 years. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.036DOI Listing
February 2019

Coronary Lithoplasty: Initial Experience in Coronary Calcified Lesions.

Rev Esp Cardiol (Engl Ed) 2019 Feb 16. Epub 2019 Feb 16.

Unidad de Cardiología Intervencionista, Servicio de Cardiología, Hospital del Mar, Universidad Autónoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.rec.2018.11.017DOI Listing
February 2019

[Usefulness of a specialised primary immunodeficiencies clinic].

An Pediatr (Barc) 2019 Feb 16. Epub 2019 Feb 16.

Servicio de Pediatría Hospitalaria, Enfermedades Infecciosas y Tropicales, Hospital Infantil Universitario La Paz, Instituto de Investigación IdiPAZ, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.anpedi.2018.12.010DOI Listing
February 2019

Hypothyroxinemia: a subclinical condition affecting neurodevelopment.

Expert Rev Endocrinol Metab 2010 Jul;5(4):563-575

b Instituto de Investigaciones Biomédicas, CSIC-UAM, Centro de Investigación Biomédica en Enfermedades Raras, CIBERER, Arturo Duperier 4, 28029 Madrid, Spain.

Hypothyroxinemia with low levels of circulating free thyroxine and normal levels of thyrotropin, which is usually caused by iodine deficiency, may affect pregnant women even in apparently iodine-sufficient areas, and it is debated whether it increases the risk of neurodevelopmental abnormalities in children born to them. Epidemiological observations indeed indicate that this is the case. Animal models show abnormal brain cortical cytoarchitecture in pups born to mildly hypothyroxinemic dams. Read More

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http://dx.doi.org/10.1586/eem.10.37DOI Listing