18,765 results match your criteria Enfermedades Infecciosas y MicrobiologA­a[Journal]


[Vibrio cholerae NO-O1/NO-O139 bacteremia in a cirrhotic patient. First case report in Peru and literatura review].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):301-305

Servicio de Enfermedades Infecciosas y Tropicales, Hospital Nacional Dos de Mayo. Lima, Perú; Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú.

Non-O1, non-O139 Vibrio cholerae (NOVC) strains are an uncommon cause of gastroenteritis. However, they have been recently associated with severe extraintestinal infections in immunocompromised hosts. Among them, bacteremia in cirrhotic patients is noteworthy. Read More

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December 2018

[Primary gastric choriocarcinoma: case report].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):297-300

Hospital Guillermo Kaelin de la Fuente. Lima, Perú; Universidad San Ignacio de Loyola, Lima, Perú.

Primary gastric choriocarcinoma (PGC) is an extremely rare and highly invasive tumor with rapid hematogenous spread. We present the case of a 57-year-old female patient who started with hematemesis and progressive episodes of melena, weight loss and epigastralgia. It is derived from the National Institute of Neoplastic Diseases where gastroscopy and biopsy are performed. Read More

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December 2018
1 Read

[Prognostic value of lymph node ratio (LNR) in patients who underwent radical gastrectomy].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):253-260

Departamento de Cirugía Oncológica Abdominal, Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.

The study objective was to evaluate the prognostic value of lymph node ratio (LNR) in patients with gastric cancer who underwent radical gastrectomy D2.

Materials And Methods: We reviewed retrospectively 498 medical records of patients with gastric cancer who were attended at the National Institute of Neoplastic Diseases (INEN) between 2008 and 2011and met the inclusion and exclusion criteria. They were distributed into 4 groups according to their LNR, LNR0: 0, LNR1: 0-0. Read More

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December 2018

Oxidative stress: therapeutic approaches for cervical cancer treatment.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e548s. Epub 2018 Dec 10.

Instituto do Cancer do Estado de Sao Paulo ICESP, Centro de Investigacao Translacional em Oncologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory responses and reactive oxygen species production. Read More

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December 2018
1 Read

Evaluating the impact of morning symptoms in COPD using the Capacity of Daily Living during the Morning (CDLM) questionnaire.

Int J Chron Obstruct Pulmon Dis 2018 26;13:3837-3844. Epub 2018 Nov 26.

Pneumology Department, Hospital Universitari Vall d'Hebron/Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain,

Purpose: The aim of this study was to evaluate the impact of morning symptoms in COPD using the Capacity of Daily Living during the Morning (CDLM) questionnaire and to determine the clinical variables that are related to CDLM scores.

Methods: This was an observational, cross-sectional, and multicenter study conducted in stable COPD patients. CDLM scores ranged from 0 to 5 and were transformed into a qualitative variable according to tertile values to compare patient characteristics. Read More

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November 2018

Ageing influences the relationship of circulating miR-33a and miR- 33b levels with insulin resistance and adiposity.

Diab Vasc Dis Res 2018 Dec 11:1479164118816659. Epub 2018 Dec 11.

1 Instituto de Investigación en Reumatología y del Sistema Musculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.

Objective:: The identification of circulating microRNAs related to abnormal metabolic function may be useful in the context of ageing, adiposity and insulin resistance. The miR-33 a/b has been shown to control the expression of genes involved in fatty acid biosynthesis, impaired metabolism and insulin resistance. In this study, we aimed to identify differences in circulating miR-33 a/b levels according to age-related metabolic impairment and increased adiposity. Read More

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December 2018

Viewing Target Distance Influences the Vestibulo-Ocular Reflex Gain when Assessed Using the Video Head Impulse Test.

Audiol Neurootol 2018 Dec 11;23(5):285-289. Epub 2018 Dec 11.

Neuro-Otology Unit, Division of Brain Sciences, Charing Cross Hospital Campus, Imperial College London, London, United

Gaze stabilization during head movements is provided by the vestibulo-ocular reflex (VOR). Clinical assessment of this reflex is performed using the video Head Impulse Test (vHIT). To date, the influence of different fixation distances on VOR gain using the vHIT has not been explored. Read More

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December 2018

Prognostic implications of markers of the metabolic phenotype in human cutaneous melanoma.

Br J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.

Background: Reprogramming of energy metabolism to enhanced aerobic glycolysis has been defined as a hallmark of cancer.

Objective: To investigate the role of the mitochondrial proteins, β-subunit of the H -ATP synthase (β-F1-ATPase), and heat-shock protein 60 (HSP60), and the glycolytic markers, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase M2 (PKM2), as well as the bioenergetic cellular (BEC) index, in melanoma progression.

Material And Methods: The expression of energy metabolism proteins were assessed on a set of different melanoma cells representing the natural biological history of the disease: primary cultures of melanocytes, radial (WM35) and vertical (WM278) growth phases, and poorly (C81-61-PA) and highly (C8161-HA) aggressive melanoma cells. Read More

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December 2018
2 Reads

Disruption of the default mode network and its intrinsic functional connectivity underlies minor hallucinations in Parkinson's disease.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, Spain.

Background: Minor hallucinations and well-structured hallucinations are considered in the severity continuum of the psychotic spectrum associated with Parkinson's disease. Although their chronological relationship is largely unknown, the spatial patterns of brain atrophy in these 2 forms of hallucinations partially overlap, suggesting they share similar pathophysiological processes. Functional connectivity studies show that disruption of functional networks involved in perception and attention could be relevant in the emergence of well-structured hallucinations. Read More

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December 2018

Aging and the Inflammasomes.

Exp Suppl 2018 ;108:303-320

Department of Physiology, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center (CIBM), University of Granada, Armilla, Spain.

The inflammasomes are innate immune system sensors that control the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules originating from host proteins, leading to the release of pro-inflammatory cytokines, Il1b and IL18, and a particular inflammatory type of cell death termed pyroptosis. It is broadly considered that chronic inflammation may be a common link in age-related diseases, aging being the greatest risk factor for the development of chronic diseases. In this sense, we discuss the role of inflammasomes in non-infectious inflammation and their interest in aging and age-related diseases. Read More

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January 2018

Genetic Lineage Tracing of Biliary Epithelial Cells.

Methods Mol Biol 2019 ;1905:45-57

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Lineage tracing of liver cells is a powerful tool to understand liver embryonic development, healthy liver cell homeostasis, tissue repair, and regeneration. Lineage tracing of biliary epithelial cells (BECs) in the adult liver has been used to assess the contribution of the biliary epithelium to liver injury, regeneration, and disease. These studies have shown the contribution of BECs to the expansion of ductular reaction (DR) and liver progenitor cells (LPCs) and eventually the generation of new hepatocytes. Read More

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January 2019

PhenoMeNal: Processing and analysis of Metabolomics data in the Cloud.

Gigascience 2018 Dec 7. Epub 2018 Dec 7.

Cheminformatics and Computational Metabolomics, Institute for Analytical Chemistry, Lessingstr. 8, 07743 Jena, Germany.

Background: Metabolomics is the comprehensive study of a multitude of small molecules to gain insight into an organism's metabolism. The research field is dynamic and expanding with applications across biomedical, biotechnological and many other applied biological domains. Its computationally-intensive nature has driven requirements for open data formats, data repositories and data analysis tools. Read More

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December 2018
3 Reads

Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial.

Am J Clin Nutr 2018 Sep;108(3):485-491

Departamento de Endocrinología y Metabolismo, and.

Background: Recently, the absence of metabolic effects from nonnutritive sweeteners has been questioned.

Objective: The aim of this study was to evaluate the effects of sucralose consumption on glucose metabolism variables.

Design: We performed a randomized controlled trial involving healthy subjects without comorbidities and with a low habitual consumption of nonnutritive sweeteners (n = 33/group). Read More

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September 2018

Next step, OPAT programs as a tool of stewardship programs.

Clin Infect Dis 2018 Dec 10. Epub 2018 Dec 10.

Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine,Institute of Biomedicine of Seville (IBiS),University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.

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December 2018
1 Read

Impact of de-escalation on prognosis of patients with bacteraemia due to Enterobacteriaceae: a post-hoc analysis from a multicenter prospective cohort.

Clin Infect Dis 2018 Dec 8. Epub 2018 Dec 8.

Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena/Departamento de Medicina y Microbiología, Universidad de Sevilla/Instituto de Biomedicina de Sevilla (IBiS). Sevilla, Spain.

Background: More data are needed about the safety of antibiotic de-escalation in specific clinical situations as a strategy to reduce exposure to broad-spectrum antibiotics. The aims of this study were to investigate predictors of de-escalation and its impact on the outcome of patients with bloodstream infection due to Enterobacteriaceae (BSI-E).

Methods: A post-hoc analysis was performed of a prospective, multicenter cohort of patients with BSI-E initially treated with ertapenem or antipseudomonal β-lactams. Read More

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December 2018
1 Read

[Chikungunya, emerging disease in Latin America. Description of the first cases in Chile].

Rev Chilena Infectol 2018 Aug;35(4):413-419

Laboratorio de Infectología y Virología Molecular, Pontificia Universidad Católica de Chile, Chile.

Background: Chikungunya (CHIK) was introduced in The Americas in 2013, spreading rapidly. In 2014, the first imported case was diagnosed in Chile.

Aim: To identify patients with clinical suspicion of CHIK and describe their clinical and laboratory characteristics. Read More

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[Spatial difference in the incidence of Argentine Hemorrhagic Fever and composition and abundance of rodents in the assemblage].

Rev Chilena Infectol 2018 Aug;35(4):386-394

Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, Córdoba, Argentina.

Background: The Argentine Hemorrhagic Fever (AHF) is a zoonotic disease endemic in a wide area of the humid pampa of Argentina. The etiologic agent is the Junin virus that is maintained in the wild by the rodent Calomys musculinus and transmitted to humans, mainly, through aerosols generated from secretions and excretions.

Aims: To characterize and compare the assemblages of small rodent composition and diversity inside the epidemic, historic and non-endemic zone of AHF and to register C. Read More

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[Outbreak of fungemias by Sarocladium kiliense in eight public hospitals per intrinsic contamination of ondansetron intravenous].

Rev Chilena Infectol 2018 Aug;35(4):363-370

Subdepartamento de Enfermedades Infecciosas, Instituto de Salud Pública de Chile, Chile.

Sarocladium kiliense is a saprophyte fungus that can cause opportunistic infections associated to invasive procedures. We report a multi-hospital nosocomial outbreak of fungemias due to this agent. Patients with positive blood culture to this agent were studied after six bloodstream infections identified in three Chilean hospitals in July 2013 were reported to Ministry of Health National Infection and Prevention Control Program. Read More

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[Evaluation of susceptibility and response to therapy with piperacillin-tazobactam in patients with infections caused by Escherichia coli with extended-spectrum β-lactamase (ESBL) CTX-M].

Rev Chilena Infectol 2018 Aug;35(4):343-350

Departamento de Enfermedades Infecciosas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Chile.

Background: Carbapenems are the preferred β-lactamics for treatment for infections caused by enterobacteria producing extended-spectrum β-lactamases (ESBL); however, clinical studies show effectiveness of piperacillin/tazobactam in certain infections by Escherichia coli ESBL producers.

Aim: To determine the clinical and micro-biological cure with piperacillin/tazobactam in patients with infections caused by E. coli ESBL producers, CTXM type. Read More

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[Directed acyclic graphs in statistical modelling of epidemiological studies].

Rev Med Chil 2018 Jul;146(7):907-913

Programa de Salud Ambiental, Escuela de Salud Pública, Universidad de Chile, Santiago, Chile.

Background: Confusion in observational epidemiological studies distorts the relationship between exposure and event. "Step by step" regression models, diverts the decision to a statistical algorithm with little causal basis. Directed Acyclic Graphs (DAGs), qualitatively and visually assess the confusion. Read More

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[Effect of metformin added to chemotherapy on the survival of patients with acute lymphoblastic leukemia].

Rev Med Chil 2018 Jul;146(7):846-853

Laboratorio de Biología Molecular, Servicio de Hematología, Hospital General de México "Dr. Eduardo Liceaga", Ciudad de México, México.

Background: Metformin has antineoplastic and cancer protective effects in vitro, sensitizing leukemia cells to chemotherapeutic agents, inducing apoptosis and cell cycle arrest.

Aim: To assess the effect of metformin on the induction stage in patients with ALL and its impact on overall survival and relapse.

Material And Methods: We included 123 patients treated with metformin and without metformin. Read More

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The Prohormone Proinsulin as a Neuroprotective Factor: Past History and Future Prospects.

Front Mol Neurosci 2018 26;11:426. Epub 2018 Nov 26.

3D Lab, Development, Differentiation and Degeneration, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CIB/CSIC), Madrid, Spain.

Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to be isolated and sequenced. While its role as an insulin precursor has been extensively studied in the field of endocrinology, the bioactivity of the proinsulin molecule itself has received much less attention. Insulin binds to isoforms A and B of the insulin receptor (IR) with high affinity. Read More

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November 2018

Genome Sequence of Chiqui Virus, a Novel Reovirus Isolated from Mosquitoes Collected in Colombia.

Microbiol Resour Announc 2018 Sep 27;7(12). Epub 2018 Sep 27.

Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA.

We report here the complete genome sequence of a novel reovirus, designated Chiqui virus (CHQV) strain CoB38d, that was isolated from a pool of unidentified mosquitoes collected in northern Colombia in 2013. CHQV has nine double-stranded DNA (dsRNA) genome segments and has similarity to viruses belonging to the family , subfamily . Read More

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September 2018
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Complete Genome Sequence of Houston Virus, a Newly Discovered Mosquito-Specific Virus Isolated from Culex quinquefasciatus in Mexico.

Microbiol Resour Announc 2018 Sep 13;7(10). Epub 2018 Sep 13.

Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.

We fully sequenced the genome of Houston virus, a recently discovered mosquito-associated virus belonging to the newly established family Mesoniviridae. The isolate was recovered from Culex quinquefasciatus in southern Mexico, which shows that the geographic range of Houston virus is not restricted to the United States in North America. Read More

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September 2018

Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease.

Oxid Med Cell Longev 2018 8;2018:1435934. Epub 2018 Nov 8.

Instituto de Investigaciones Biomédicas Alberto Sols (IIBM), Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid (CSIC-UAM), 28029 Madrid, Spain.

Mitochondria are highly dynamic and regulated organelles that historically have been defined based on their crucial role in cell metabolism. However, they are implicated in a variety of other important functions, making mitochondrial dysfunction an important axis in several pathological contexts. Despite that conventional biochemical and molecular biology approaches have provided significant insight into mitochondrial functionality, innovative techniques that provide a global view of the mitochondrion are still necessary. Read More

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November 2018

[Índices para la evaluación de la resistencia a la insulina en individuos mexicanos sin diabetes].

Gac Med Mex 2018 ;154(Supp 2):S50-S55

Departamento de Endocrinología y Metabolismo, Ciudad de México, México.

Objective: To evaluate the correlation between subrogate index for the evaluation of insulin resistance with the M value obtained with the euglycemic-hyperinsulinemic clamp as well as their sensitivity, specificity, and positive and negative predictive values.

Method: The euglycemic-hyperinsulinemic clamp was performed in subjects having both normal fasting glucose and glycated hemoglobin concentrations. HOMA-IR, QUICKI, HOMA2%S, TyG, TyG*body mass index (BMI) and triglyceride/HDL indexes were calculated. Read More

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January 2018

[Los niveles de mediadores prorresolutivos no corresponden con los de mediadores inflamatorios en enfermedades isquémicas coronarias].

Gac Med Mex 2018 ;154(Supp 2):S9-S14

Departmento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez. Ciudad de México, México.

Background: Inflammation can be grouped into three phases: proinflammatory, anti-inflammatory, and resolution. The latter, mainly attributed to lipid mediators, is the most recently described, and has been studied little in coronary ischemic diseases.

Objective: To evaluate 1) if acute coronary syndromes (ACS) manifest different circulating levels of resolution mediators compared with stable angina (SA); 2) if their concentrations are related to those of pro and anti-inflammatory mediators; and 3) if such concentrations are associated with the severity of the disease and the damage produced. Read More

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January 2018

[Péptidos antimicrobianos, una alternativa prometedora para el tratamiento de enfermedades infecciosas].

Gac Med Mex 2018 ;154(6):681-688

Universidad Autónoma Metropolitana Unidad Xochimilco, Ciudad de México, México.

Microorganisms that cause diseases in humans are constantly evolving, which represents a challenge in the search for effective treatments against them. Even when currently there are several pharmacological alternatives available, sometimes they are inefficient for the control of infectious diseases, especially because pathogens have generated multiple resistance mechanisms against them. Antimicrobial peptides have been described in many species of organisms, from fungi, plants and insects to humans; currently, there are molecules that appear as a solution that can be effective in modern therapeutics. Read More

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January 2018

[Breve recorrido histórico de la enfermedad de Parkinson a 200 años de su descripción].

Gac Med Mex 2018 ;154(6):719-726

Laboratorio Clínico de Enfermedades Neurodegenerativas. Secretaría de Salud, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.

The original description of what currently is known as Parkinson's disease was published 200 years ago. During both these centuries, knowledge on symptomatology, pathophysiology, genetics and pharmaceutical and surgical treatment has significantly increased; however, this nosological entity continues to be of imprecise origin and progressive evolution. In the present review, the historical events that contributed to describe and improve the understanding of this disease are summarized. Read More

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January 2018

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging.

J Vis Exp 2018 Nov 20(141). Epub 2018 Nov 20.

Advanced Imaging Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), CIBER de Enfermedades Respiratorias (CIBERES);

Here, we describe a microwave synthesis to obtain iron oxide nanoparticles core-doped with Ga. Microwave technology enables fast and reproducible synthetic procedures. In this case, starting from FeCl3 and citrate trisodium salt, iron oxide nanoparticles coated with citric acid are obtained in 10 min in the microwave. Read More

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November 2018
1 Read

Nested Polymerase Chain Reaction and Cutaneous Tuberculosis.

Am J Dermatopathol 2018 Nov 27. Epub 2018 Nov 27.

Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional SXXI, IMSS, Mexico City, México.

The role of Mycobacterium tuberculosis in the etiology and pathogenesis of cutaneous tuberculosis is controversial because of the difficulties associated with demonstrating the presence of these mycobacteria in tuberculid cutaneous lesions by routinely available microbiological and histological techniques. In this study, we aimed to demonstrate the presence of M. tuberculosis in cutaneous tuberculosis. Read More

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November 2018

Physical Activity Is Associated with Attenuated Disease Progression in COPD.

Med Sci Sports Exerc 2018 Dec 7. Epub 2018 Dec 7.

ISGlobal, Barcelona, Spain[ZERO WIDTH SPACE].

Introduction: COPD progression is variable and affects several disease domains, including decline in lung function, exercise capacity, muscle strength and health status as well as changes in body composition. We aimed to assess the longitudinal association of physical activity (PA) with these a priori selected components of disease progression.

Method: We studied 114 COPD patients from the PAC-COPD cohort [94% male, mean (SD) 70 (8) years of age, 54 (16) FEV1 % predicted] at baseline and 2. Read More

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December 2018

Accelerated aging induced by deficiency of Zmpste24 protects old mice to develop bleomycin-induced pulmonary fibrosis.

Aging (Albany NY) 2018 Dec 10. Epub 2018 Dec 10.

Facultad de Ciencias Universidad Nacional Autonoma de México, Mexico City, Mexico.

Idiopathic pulmonary fibrosis is a devastating aging-associated disease of unknown etiology. Despite that aging is a major risk factor, the mechanisms linking aging with this disease are uncertain, and experimental models to explore them in lung fibrosis are scanty. We examined the fibrotic response to bleomycin-induced lung injury in mice, which exhibit nuclear lamina defects developing accelerated aging. Read More

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December 2018

Paradigm changes for diagnosis: using big data for prediction.

Clin Chem Lab Med 2018 Dec 11. Epub 2018 Dec 11.

Hospital Clínic, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Barcelona, Catalunya, Spain.

Due to profound changes occurring in biomedical knowledge and in health systems worldwide, an entirely new health and social care scenario is emerging. Moreover, the enormous technological potential developed over the last years is increasingly influencing life sciences and driving changes toward personalized medicine and value-based healthcare. However, the current slow progression of adoption, limiting the generation of healthcare efficiencies through technological innovation, can be realistically overcome by fostering convergence between a systems medicine approach and the principles governing Integrated Care. Read More

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December 2018

Real-life experience with ceftolozane/tazobactam in patients with hematologic malignancy and infection: a case-control study.

Antimicrob Agents Chemother 2018 Dec 10. Epub 2018 Dec 10.

Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain.

Background: We present our experience in patients with hematologic malignancy and infection treated with ceftolozane-tazobactam.

Materials/methods: We performed a single-center case-control study including all patients with hematologic malignancy and infection treated with ceftolozane-tazobactam (study group) and compared them with similar patients not treated with ceftolozane-tazobactam (control group) to assess safety and efficacy.

Results: Nineteen cases and 38 controls were analyzed. Read More

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December 2018

Muscle MRI in a large cohort of patients with oculopharyngeal muscular dystrophy.

J Neurol Neurosurg Psychiatry 2018 Dec 8. Epub 2018 Dec 8.

Neuromuscular Disorders Unit, Neurology Department, Hospital de la Santa Creu I Sant Pau, Universidad Autónoma de Barcelona, Barcelona, Spain

Background And Objective: Oculopharyngeal muscular dystrophy (OPMD) is a genetic disorder caused by an abnormal expansion of GCN triplets within the gene. Previous descriptions have focused on lower limb muscles in small cohorts of patients with OPMD, but larger imaging studies have not been performed. Previous imaging studies have been too small to be able to correlate imaging findings to genetic and clinical data. Read More

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December 2018
1 Read

Doxylamine Allergy in a Pregnant Woman: Suitability of the Basophil Activation Test.

J Investig Allergol Clin Immunol 2018 Dec;28(6):433-434

Immunology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.

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December 2018

Leukocytoclastic Vasculitis After Influenza Vaccination: An Allergy Assessment.

J Investig Allergol Clin Immunol 2018 Dec;28(6):417-418

Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias, Departamento de Medicina y Especialidades Médicas; Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.

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December 2018

Genital morphology and copulatory behavior in triatomine bugs (Reduviidae: Triatominae).

Arthropod Struct Dev 2018 Dec 6. Epub 2018 Dec 6.

CONACYT-Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Avenida Universidad 655, Col. Santa María Ahuacatitlán, Cerrada Los Pinos y Caminera, 62100, Cuernavaca, Morelos, México. Electronic address:

Triatomines (Heteroptera: Reduviidae) include around 139 species, widely known as vectors of Chagas disease. Our aim is to review the existing knowledge of the genital morphology and sexual behavior and provide some functional analysis of these traits in triatomines. A complex set of traits comprise genitalia and these are highly variable among species. Read More

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December 2018

Antisepsis for blood culture extraction. Blood culture contamination rate.

Med Intensiva 2018 Oct 24. Epub 2018 Oct 24.

Unidad de Medicina Intensiva, Hospital Universitario y Politécnico la Fe, Valencia, España.

Blood cultures are the gold standard for the etiological diagnosis of bacteremia, though false-positive results are relatively frequent primarily due to contamination from skin flora during sample extraction. Correct skin antisepsis is important for reducing the bacterial load and opportunities for contamination. However, there is currently no solid consensus on the best antiseptic method. Read More

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October 2018

Kidney, hypertension and complement activation. In search of new therapeutic targets.

Nefrologia 2018 Dec 6. Epub 2018 Dec 6.

UGC de Nefrología, Hospital Universitario Reina Sofía, Córdoba; Instituto Maimónides de Investigación Biomedica de Córdoba (IMIBIC), Córdoba, España. Electronic address:

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December 2018

Pathophisiology of abdominal aortic aneurysm: biomarkers and novel therapeutic targets.

Clin Investig Arterioscler 2018 Dec 6. Epub 2018 Dec 6.

CIBER de Enfermedades Cardiovasculares (CIBERCV), España; Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, España. Electronic address:

Abdominal aortic aneurysm (AAA) is a vascular pathology with a high rate of morbidity and mortality and a prevalence that, in men over 65 years, can reach around 8%. In this disease, usually asymptomatic, there is a progressive dilatation of the vascular wall that can lead to its rupture, a fatal phenomenon in more than 80% of cases. The treatment of patients with asymptomatic aneurysms is limited to periodic monitoring with imaging tests, control of cardiovascular risk factors and treatment with statins and antiplatelet therapy. Read More

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December 2018

Whole sequence of the mitochondrial DNA genome of Kearns Sayre Syndrome patients: Identification of deletions and variants.

Gene 2018 Dec 4. Epub 2018 Dec 4.

Department of Neurology and Paediatrics, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.

Mitochondria both produce the energy of the cell as ATP via respiration and regulate cellular metabolism. Accordingly, any deletion or mutation in the mitochondrial DNA (mtDNA) may result in a disease. One of these diseases is Kearns Sayre syndrome (KSS), described for the first time in 1958, where different large-scale deletions of different sizes and at different positions have been reported in the mitochondrial genome of patients with similar clinical symptoms. Read More

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December 2018

Prognosis of deep infection in spinal surgery using implants, treated by retention, removal of bone graft and lengthy antibiotherapy.

Rev Esp Cir Ortop Traumatol 2018 Dec 6. Epub 2018 Dec 6.

Departamento de Cirugía Ortopédica y Traumatología, Hospital Regional Universitario de Málaga, Málaga, España.

Objective: Surgical site infections (SSIs) are complications that predispose to a high risk of unfavourable surgical outcomes. The aim of this study was to assess the SSI rate in this type of patients and their prognosis with similar treatment.

Materials And Methods: A retrospective case series of 799 patients above 18 years old with spinal instrumentation surgery, between January 2010 and December 2014 in the traumatology and orthopaedic surgery department of our institution. Read More

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December 2018

Esophageal blind sac fistula.

Cir Esp 2018 Dec 7. Epub 2018 Dec 7.

Departamento de Cirugía Oncológica, Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú; Escuela de Postgrado, Universidad Privada San Martín de Porres, Lima, Perú.

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December 2018

Children Present a Window of Opportunity for Promoting Health: JACC Review Topic of the Week.

J Am Coll Cardiol 2018 Nov 23. Epub 2018 Nov 23.

The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. Electronic address:

Cardiovascular disease is the leading cause of death and disability in the world, largely because of risk factors modifiable by changes in behavior. There is evolving evidence that our behavior as adults has its roots in the environment that we live in from early childhood. Early sustained multicomponent educational programs focused on health promotion in children may represent a window of opportunity to potentially prevent disease in adulthood. Read More

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November 2018
1 Read

Escherichia coli lipopolysaccharide induces alveolar epithelial cell stiffening.

J Biomech 2018 Nov 29. Epub 2018 Nov 29.

Unitat de Biofísica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias CIBERES, Madrid, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain. Electronic address:

Introduction: Application of lipopolysaccharide (LPS) is a widely employed model to mimic acute respiratory distress syndrome (ARDS). Available data regarding LPS-induced biomechanical changes on pulmonary epithelial cells are limited only to P. aeruginosa LPS. Read More

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November 2018

Palliative Care: Perceptions, Experiences, and Attitudes in a Peruvian Neurologic Hospital.

J Palliat Med 2018 Dec 8. Epub 2018 Dec 8.

6 Department of Neurology, University of Washington , Seattle, Washington.

Background: The development of palliative care in Peru remains limited, particularly for nononcological services, such as neurology. The goal of this study was to explore attitudes toward and knowledge about palliative and end-of-life care among patients, families, nurses, and doctors in a specialized neurological institute in Lima, Peru.

Materials And Methods: We used a mixed methods approach consisting of 78 surveys and 21 qualitative, semistructured interviews that were recorded, transcribed, and analyzed using thematic analysis. Read More

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December 2018

Abdominal tuberculosis in renal transplant recipient. Presentation of a case and literature review

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):414-417. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Unidad de Investigación Médica en Enfermedades Nefrológicas. Ciudad de México, México

Background: Kidney transplantation presents a susceptible point, and is related to infections; tuberculosis is a common and endemic etiology in a country like Mexico, where the most frequent presentation is the respiratory condition, the extrapulmonary is extremely rare and it is derived from immunosuppression conditions.

Case Report: 33-year-old man with kidney disease of undetermined etiology, kidney transplant in 2003 (donor mother) with adequate evolution; presented with chronic graft nephropathy, with baseline creatinine of 1.8 mg / dL, immunosuppression with prednisone 10 mg every 24 hours, mycophenolate mofetil 500 mg every 8 hours and ciclosporin 100 mg every 12 hours; surgical intervention was performed due to acute abdomen, appendectomy and omentectomy with histopathological finding of tuberculosis, Dotbal, antiproliferative in suspension was started and decrease of calcineurin inhibitor. Read More

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November 2018

In memory of Dr. Arturo Zárate Treviño, pioneer in the study of gynecological endocrinology in Mexico

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):334-339. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez”, Unidad de Investigación Médica de Enfermedades Endocrinas. Ciudad de México, México

No abstract Read More

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November 2018