19,857 results match your criteria Enfermedades Infecciosas y MicrobiologA­a[Journal]


Collagen XIX Alpha 1 Improves Prognosis in Amyotrophic Lateral Sclerosis.

Aging Dis 2019 Apr 1;10(2):278-292. Epub 2019 Apr 1.

2Neurology Department, ALS Unit, CIBERER U-723, Health Research Institute, October 12th Hospital "IIS I+12", Madrid, Spain.

The identification of more reliable diagnostic or prognostic biomarkers in age-related neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS), is urgently needed. The objective in this study was to identify more reliable prognostic biomarkers of ALS mirroring neurodegeneration that could be of help in clinical trials. A total of 268 participants from three cohorts were included in this study. Read More

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http://dx.doi.org/10.14336/AD.2018.0917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457048PMC

Follow-up losses of people with HIV infection: A weak point in the continuum of care.

Enferm Infecc Microbiol Clin 2019 Apr 19. Epub 2019 Apr 19.

Servicio de Enfermedades Infecciosas, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, IRYCIS, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.eimc.2019.03.006DOI Listing

Assessment of Diet Quality in Chilean Urban Population through the Alternate Healthy Eating Index 2010: A Cross-Sectional Study.

Nutrients 2019 Apr 20;11(4). Epub 2019 Apr 20.

Centro de Nutrición Molecular y Enfermedades Crónicas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330033, Chile.

Most worldwide causes of disease and death are strongly associated with dietary factors and the application of eating indexes has proved to be a useful tool to determine diet quality in populations. The aim of this study was to evaluate the diet quality in Chile through the application of the Alternate Healthy Eating Index 2010 (AHEI-2010). A representative sample ( = 879) of Chilean urban population aged 15⁻65 years old from the Latin American Study of Nutrition and Health (; ELANS) was used. Read More

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http://dx.doi.org/10.3390/nu11040891DOI Listing

Rivaroxaban for secondary stroke prevention in patients with embolic strokes of undetermined source: Design of the NAVIGATE ESUS randomized trial.

Eur Stroke J 2016 Sep 3;1(3):146-154. Epub 2016 Aug 3.

Department of Medicine (Cardiology), Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Canada.

Background: Embolic strokes of undetermined source comprise up to 20% of ischemic strokes. The stroke recurrence rate is substantial with aspirin, widely used for secondary prevention. The New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus ASA to prevenT Embolism in Embolic Stroke of Undetermined Source international trial will compare the efficacy and safety of rivaroxaban, an oral factor Xa inhibitor, versus aspirin for secondary prevention in patients with recent embolic strokes of undetermined source. Read More

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http://dx.doi.org/10.1177/2396987316663049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301240PMC
September 2016

Novel Circulating miRNA Signatures for Early Detection of Pancreatic Neoplasia.

Clin Transl Gastroenterol 2019 Apr 15. Epub 2019 Apr 15.

Gastrointestinal & Pancreatic Oncology Group, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)/Hospital Clínic of Barcelona/Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain.

Objectives: Pancreatic ductal adenocarcinoma (PDAC) presents the lowest survival rate of all cancers because only 6% of patients reach five-year survival. Alterations in the expression of several microRNAs (miRNAs) occur in the tumor of PDAC and in preneoplastic lesions as the called intraductal papillary mucinous neoplasm (IPMN). Here, we aimed at identifying which miRNAs are significantly altered in liquid biopsies from patients with PDAC and IPMN to find new noninvasive biomarkers for early detection of PDAC. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000029DOI Listing

Multimodality and Fusion Imaging in Percutaneous Therapy of Tricuspid Regurgitation.

Rev Esp Cardiol (Engl Ed) 2019 May 7;72(5):421-422. Epub 2018 Jul 7.

Servicio de Cardiología, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Universidad Autónoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.rec.2018.04.027DOI Listing

Parenteral drug use as the main barrier to hepatitis C treatment uptake in HIV-infected patients.

HIV Med 2019 Apr 22. Epub 2019 Apr 22.

Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Córdoba, Spain.

Objectives: Our objective was to identify patient factors associated with being untreated for hepatitis C virus (HCV) infection in HIV-coinfected patients.

Methods: A prospective longitudinal study was carried out. HIV-infected patients with active chronic HCV infection included in the HERACLES cohort (NCT02511496) constituted the study population. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hiv.12715
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http://dx.doi.org/10.1111/hiv.12715DOI Listing
April 2019
1 Read

Adalimumab or Infliximab for the Prevention of Early Postoperative Recurrence of Crohn Disease: Results From the ENEIDA Registry.

Inflamm Bowel Dis 2019 Apr 22. Epub 2019 Apr 22.

Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain.

Background: Anti-tumor necrosis factor agents (anti-TNFs) are efficacious at preventing the postoperative recurrence (POR) of Crohn disease, as demonstrated in 2 randomized controlled trials. However, real-life data for infliximab or adalimumab in this setting are scarce. Our aim was to assess both the efficiency of anti-TNFs at preventing early POR of Crohn disease in clinical practice and the associated risk factors for POR. Read More

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https://academic.oup.com/ibdjournal/advance-article/doi/10.1
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http://dx.doi.org/10.1093/ibd/izz084DOI Listing
April 2019
2 Reads

Clarifications to «First described case of coma triggered by retrograde venous air embolism: An exceptional but potentially life-threatening situation».

Neurologia 2019 Apr 18. Epub 2019 Apr 18.

Servicio de Medicina Interna, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.

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http://dx.doi.org/10.1016/j.nrl.2018.12.001DOI Listing

The Spanish Network of Agencies for Health Technology Assessment and Services of the National Health System (RedETS).

Int J Technol Assess Health Care 2019 Apr 22:1-5. Epub 2019 Apr 22.

Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC).

Earlier activities on health technology assessment (HTA) started in Spain around 1984, with the creation of a National Advisory Board on HTA, and the development of national and regional HTA organizations in the early 1990s. In 2012, the Spanish Health Ministry established the Spanish Network for Health Technology Assessment of the National Health System (RedETS); funded at national level and including all public HTA organizations at national and regional levels. RedETSis focused on the assessment of nondrug health technologies to inform the revision (approval and funding or disinvestment) of the Benefit Portfolio of the Spanish NHS. Read More

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http://dx.doi.org/10.1017/S0266462319000205DOI Listing

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.

Acta Neuropathol 2019 Apr 20. Epub 2019 Apr 20.

Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, 221 84, Lund, Sweden.

Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pathology. Gal3 was highly upregulated in the brains of AD patients and 5xFAD (familial Alzheimer's disease) mice and found specifically expressed in microglia associated with Aβ plaques. Read More

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http://dx.doi.org/10.1007/s00401-019-02013-zDOI Listing

Rapid automatic identification of parameters of the Bergman Minimal Model in Sprague-Dawley rats with experimental diabetes for adaptive insulin delivery.

Comput Biol Med 2019 Apr 8;108:242-248. Epub 2019 Apr 8.

IEEE Engineering in Medicine and Biology, Mexico City, Mexico. Electronic address:

Glucose-Insulin regulation models can be used to individualize insulin therapy. However, the experimental techniques currently used to identify the appropriate parameter sets of an individual are expensive, time consuming, and very unpleasant for the patient. Since there is a wide range of intrapersonal parameter variability, the identified parameters in a laboratory setting (at rest) are not optimal for dynamic conditions of daily activities. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.028DOI Listing

Smartwatch for the analysis of rest tremor in patients with Parkinson's disease.

J Neurol Sci 2019 Apr 9;401:37-42. Epub 2019 Apr 9.

Medicine Department, Faculty of Medicine, Universidad Complutense Madrid (UCM), Spain; Neurology Department, Hospital Universitario 12 de Octubre, Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain.

Wearable technology used in Parkinson's disease (PD) research has become an increasing focus of interest in this field. Our group assessed the feasibility, clinical correlation, reliability, and acceptance of smartwatches in order to quantify arm resting tremors in PD patients. An Android application on a smartwatch was used to obtain raw data from the smartwatch's gyroscopes. Read More

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http://dx.doi.org/10.1016/j.jns.2019.04.011DOI Listing

The Combined Use of Pleural Fluid Parameters Improves Diagnostic Accuracy in Complicated Pleural Infection/Empyema.

Arch Bronconeumol 2019 Apr 17. Epub 2019 Apr 17.

Servicio de Neumología, Complejo Hospitalario Clínico Universitario de Santiago de Compostela, Grupo Interdisciplinar de Investigación en Neumología. Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, A Coruña, España.

Introduction: Identifying infectious pleural effusions (IPE) that will progress to complicated infection or empyema is challenging. The purpose of this study was to determine whether a model based on multiple biochemical parameters in pleural fluid can predict which IPEs will produce empyema.

Methods: A prospective study was performed of all cases of IPEs treated in our unit. Read More

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http://dx.doi.org/10.1016/j.arbres.2019.02.025DOI Listing

Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75].

Metabolism 2019 Apr 17. Epub 2019 Apr 17.

Pharmacology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2019.04.009DOI Listing

Evaluation of two approaches to lysosomal acid lipase deficiency patient identification: An observational retrospective study.

Atherosclerosis 2019 Mar 18;285:49-54. Epub 2019 Mar 18.

Instituto de Investigación Sanitaria Aragón (IIS Aragón), GIIS-012, Zaragoza, 50009, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), CB/06/07/1036, Instituto de Salud Carlos III (ISCIII), Hospital Universitario Miguel Servet, Zaragoza, 50009, Spain; Fundación Española para el Estudio y Terapéutica de la Enfermedad de Gaucher y Otras Lisosomales (FEETEG), Zaragoza, 50008, Spain.

Background And Aims: Lysosomal acid lipase deficiency (LALD) leads to the accumulation of cholesteryl esters and/or triglycerides (TG) in lysosomes due to the lack of the enzyme codified by the LIPA gene. The most common symptoms are dyslipidaemia and hypertransaminasemia, together with manifestations common to other lysosomal storage disorders (LSDs), including visceromegalies and elevated plasma biomarkers. Alteration of the lipid-liver profile (LLP) has been widely applied as a criterion for LALD screening, but the usefulness of biomarkers has not yet been explored. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.03.013DOI Listing

Assessment of analgesia, sedation, physical restraint and delirium in patients admitted to Spanish intensive care units. Proyecto ASCyD.

Enferm Intensiva 2019 Apr 16. Epub 2019 Apr 16.

Grupo de Trabajo de Analgesia, Sedación, Contenciones y Delirio de la Sociedad Española de Enfermería Intensiva y Unidades Coronarias (GT-ASCyD-SEEIUC), España; Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, España; Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana (IDIPHISA), Majadahonda, Madrid, España.

Aims: Main aim: To determine the Spanish intensive care units (ICU) that assess and record pain levels, sedation/agitation, delirium and the use of physical restraint (PR) as standard practice. Secondary aims: To determine the use of validated assessment tools and to explore patients' levels of pain and sedation/agitation, the prevalence of delirium, and the use of PR.

Method: An observational, descriptive, cross-sectional, prospective and multicentre study using an ad hoc survey with online access that consisted of 2 blocks. Read More

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http://dx.doi.org/10.1016/j.enfi.2018.11.002DOI Listing

Clinical guide for the diagnosis and follow-up of myotonic dystrophy type 1, MD1 or Steinert's disease.

Neurologia 2019 Apr 16. Epub 2019 Apr 16.

Servicio de Neurología, Hospital Universitario 12 de Octubre, Madrid, España.

Background And Objectives: Steinert's disease or myotonic dystrophy type 1 (MD1), (OMIM 160900), is the most prevalent myopathy in adults. It is a multisystemic disorder with dysfunction of virtually all organs and tissues and a great phenotypical variability, which implies that it has to be addressed by different specialities with experience in the disease. The knowledge of the disease and its management has changed dramatically in recent years. Read More

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http://dx.doi.org/10.1016/j.nrl.2019.01.001DOI Listing

Cohort study showed that growth rate increment has not been enough to prevent growth retardation of preterm infants and raised concerns about unbalanced growth.

Acta Paediatr 2019 Apr 19. Epub 2019 Apr 19.

Neonatology Department, Hospital Universitario La Paz, Hospital La Paz Institute for Health Research, Madrid, Spain.

Aim: We describe the postnatal weight gain, linear and head growth trends of surviving preterm infants from 2005 to 2017.

Methods: Multicentre cohort study, including surviving preterm infants < 32 weeks (n=21,084), from the Spanish Neonatal Network database, without major congenital malformations who were less than 50 weeks postmenstrual age at discharge. Outcomes were weight gain (g/kg/day), linear and head growth (cm/week) and changes in weight, length and head circumference z-scores from birth to discharge. Read More

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http://dx.doi.org/10.1111/apa.14819DOI Listing

Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells.

J Immunol Res 2019 14;2019:9678098. Epub 2019 Mar 14.

Subdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), México City, Mexico.

Valproic acid (VPA) is widely recognized for its use in the control of epilepsy and other neurological disorders in the past 50 years. Recent evidence has shown the potential of VPA in the control of certain cancers, owed in part to its role in modulating epigenetic changes through the inhibition of histone deacetylases, affecting the expression of genes involved in the cell cycle, differentiation, and apoptosis. The direct impact of VPA in cells of the immune system has only been explored recently. Read More

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https://www.hindawi.com/journals/jir/2019/9678098/
Publisher Site
http://dx.doi.org/10.1155/2019/9678098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437734PMC
March 2019
1 Read

Recent advances in managing/understanding the metabolic syndrome.

F1000Res 2019 3;8. Epub 2019 Apr 3.

Unidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14008, Mexico.

The metabolic syndrome (MetS) concept gathers in a single entity a set of metabolic abnormalities that have in common a close relationship with ectopic deposit of lipids, insulin resistance, and chronic low-grade inflammation. It is a valuable teaching tool to help health professionals to understand and integrate the consequences of lipotoxicity and the adverse metabolic consequences of insulin resistance. Also, it is useful to identify subjects with a high risk for having incident type 2 diabetes. Read More

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https://f1000research.com/articles/8-370/v1
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http://dx.doi.org/10.12688/f1000research.17122.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449786PMC
April 2019
1 Read

Mutations From Whole Exome Sequencing in Neurodevelopmental and Psychiatric Disorders: From Discovery to Application.

Front Genet 2019 3;10:258. Epub 2019 Apr 3.

Shanghai Mental Health Center, School of Biomedical Engineering, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Neurodevelopmental and psychiatric disorders are a highly disabling and heterogeneous group of developmental and mental disorders, resulting from complex interactions of genetic and environmental risk factors. The nature of multifactorial traits and the presence of comorbidity and polygenicity in these disorders present challenges in both disease risk identification and clinical diagnoses. The genetic component has been firmly established, but the identification of all the causative variants remains elusive. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2019.00258
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http://dx.doi.org/10.3389/fgene.2019.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456656PMC
April 2019
1 Read

Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes.

Sci Rep 2019 Apr 18;9(1):6274. Epub 2019 Apr 18.

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.

We aimed to explore the relationship between GLP-1 receptor (GLP-1R) expression in adipose tissue (AT) and incretin secretion, glucose homeostasis and weight loss, in patients with morbid obesity and type 2 diabetes undergoing bariatric surgery. RNA was extracted from subcutaneous (SAT) and visceral (VAT) AT biopsies from 40 patients randomized to metabolic gastric bypass, sleeve gastrectomy or greater curvature plication. Biochemical parameters, fasting plasma insulin, glucagon and area under the curve (AUC) of GLP-1 following a standard meal test were determined before and 1 year after bariatric surgery. Read More

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http://dx.doi.org/10.1038/s41598-019-42770-1DOI Listing

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction.

Nat Commun 2019 Apr 18;10(1):1807. Epub 2019 Apr 18.

Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028, Barcelona, Spain.

L-amino acid transporters (LATs) play key roles in human physiology and are implicated in several human pathologies. LATs are asymmetric amino acid exchangers where the low apparent affinity cytoplasmic side controls the exchange of substrates with high apparent affinity on the extracellular side. Here, we report the crystal structures of an LAT, the bacterial alanine-serine-cysteine exchanger (BasC), in a non-occluded inward-facing conformation in both apo and substrate-bound states. Read More

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http://dx.doi.org/10.1038/s41467-019-09837-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472337PMC

Geographic distribution of COPD prevalence in the World displayed by Geographic Information System maps.

Eur Respir J 2019 Apr 18. Epub 2019 Apr 18.

Marc Miravitlles, Pneumology Department, Hospital Universitari Vall d'Hebron/Vall d'Hebron Research Institute (VHIR), CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain

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http://dx.doi.org/10.1183/13993003.00610-2019DOI Listing

Prevalence and factors associated with statin use in high-risk patients with type 1 diabetes from a specialized diabetes unit.

Endocrinol Diabetes Nutr 2019 Apr 15. Epub 2019 Apr 15.

Endocrinology and Nutrition Department, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

Introduction: The use of statins in non-selected type 1 diabetes (T1D) populations is low. We assessed the prevalence and factors associated with statin treatment in patients meeting criteria for this therapy for primary prevention of cardiovascular disease (CVD).

Material And Methods: From 2015 to 2018, T1D patients from a tertiary hospital were selected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25300164193005
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http://dx.doi.org/10.1016/j.endinu.2019.02.004DOI Listing
April 2019
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Global lung health: the dangers of mild lung function impairment.

Lancet Glob Health 2019 May;7(5):e542-e543

Centro Investigación Biomédica En Red Enfermedades Respiratorias (CIBERES), Barcelona, Spain; Fundació Clínic per a la Recerca Biomèdica, Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain; Pulmonary Service, Respiratory Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X193015
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http://dx.doi.org/10.1016/S2214-109X(19)30156-1DOI Listing
May 2019
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Inequalities in health-related quality of life according to age, gender, educational level, social class, body mass index and chronic diseases using the Spanish value set for Euroquol 5D-5L questionnaire.

Health Qual Life Outcomes 2019 Apr 18;17(1):69. Epub 2019 Apr 18.

Unidad de Investigación AP-OSIs Gipuzkoa, Hospital Alto Deba, Avda Navarra 16, Arrasate-Mondragón, 20500, Gipuzkoa, Spain.

Background: Reducing health inequalities on the basis of social factors has been a key driver in the development of Public Health policies. Health-related quality of life is a global indicator useful to assess health inequalities within a society. The objective of this study was to identify inequalities on health by analysing the interactive effects of gender, age, educational level, social class, body mass index and chronic diseases on health-related quality of life in a Spanish population sample. Read More

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http://dx.doi.org/10.1186/s12955-019-1134-9DOI Listing

Immune reconstitution inflammatory syndrome associated with secondary syphilis: dermatologic, neurologic and ophthalmologic compromise in an HIV patient.

Int J STD AIDS 2019 Apr 10;30(5):509-511. Epub 2019 Jan 10.

1 Servicio de Enfermedades Infecciosas y Tropicales. Hospital Nacional Dos de Mayo, Lima, Peru.

The presentation of syphilis as a manifestation of immune reconstitution inflammatory syndrome in patients with human immunodeficiency virus (HIV) infection is rare and can be associated with the varied clinical expression of unusual syphilitic manifestations. We report a case of immune reconstitution syndrome with dermatologic, ophthalmologic and neurologic compromise of secondary syphilis in a patient with HIV infection. Read More

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http://dx.doi.org/10.1177/0956462418813045DOI Listing

EGFR and KRAS Mutations in the Non-Tumoral Lung. Prognosis in Patients with Adenocarcinoma.

J Clin Med 2019 Apr 17;8(4). Epub 2019 Apr 17.

Respiratory Medicine Department, Hospital del Mar, 08003 Barcelona, Spain.

Tumor recurrence is frequent and survival rates remain extremely low in lung adenocarcinoma (ADC). We hypothesize that carcinogenic factors will promote loco-regional modifications not only in the future tumor, but throughout the exposed lung.

Objective: To analyze whether the most prevalent mutations observed in ADC can also be observed in the non-neoplastic lung tissue, as well as the short-term prognosis implications of this finding. Read More

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https://www.mdpi.com/2077-0383/8/4/529
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http://dx.doi.org/10.3390/jcm8040529DOI Listing
April 2019
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Immunoescape the link between emphysema and lung cancer?

J Thorac Dis 2019 Mar;11(Suppl 3):S329-S330

Institut d´Investigació Sanitària de les Illes Balears (IdISBa), Palma de Mallorca, Spain.

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http://jtd.amegroups.com/article/view/26403/20225
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http://dx.doi.org/10.21037/jtd.2018.12.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424755PMC
March 2019
2 Reads

Author Correction: Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size.

Sci Rep 2019 Apr 17;9(1):6395. Epub 2019 Apr 17.

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Departament de Medicina, Barcelona, Spain.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-42591-2DOI Listing

Genetic analyses of aplastic anemia and idiopathic pulmonary fibrosis patients with short telomeres, possible implication of DNA-repair genes.

Orphanet J Rare Dis 2019 Apr 17;14(1):82. Epub 2019 Apr 17.

Instituto de Investigaciones Biomedicas CSIC/UAM, IDIPaz, Arturo Duperier, 4, 28029, Madrid, Spain.

Background: Telomeres are nucleoprotein structures present at the terminal region of the chromosomes. Mutations in genes coding for proteins involved in telomere maintenance are causative of a number of disorders known as telomeropathies. The genetic origin of these diseases is heterogeneous and has not been determined for a significant proportion of patients. Read More

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https://ojrd.biomedcentral.com/articles/10.1186/s13023-019-1
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http://dx.doi.org/10.1186/s13023-019-1046-0DOI Listing
April 2019
4 Reads

Reactive oxygen species as mediators of oxygen signaling during fetal-to-neonatal circulatory transition.

Free Radic Biol Med 2019 Apr 14. Epub 2019 Apr 14.

Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.

Reactive oxygen species (ROS) are frequently seen as pathological agents of oxidative stress. However, ROS are not always deleterious and can also act as cell signaling molecules. Vascular oxygen sensing and signaling during fetal-to-neonatal circulatory transition is a remarkable example of the physiological regulatory actions of ROS. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.008DOI Listing

Rates, Predictors and Mortality of Community-Onset Bloodstream Infections due to Pseudomonas aeruginosa: Systematic Review and Meta-Analysis.

Clin Microbiol Infect 2019 Apr 14. Epub 2019 Apr 14.

Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena / Departamento de Medicina, Universidad de Sevilla / Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain.

Background: Pseudomonas aeruginosa is mostly a nosocomial pathogen affecting predisposed patients. However, community-onset bloodstream infections (CO-BSI) caused by this organism are not exceptional.

Objectives: To assess the predisposing factors for CO-BSI due to P. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.04.005DOI Listing
April 2019
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Redescription of immatures of Dasyhelea flavifrons Guérin-Méneville (Culicomorpha: Ceratopogonidae) and new contribution to the knowledge of its larval habitats.

An Acad Bras Cienc 2019 8;91(1):e20180047. Epub 2019 Apr 8.

Centro de Estudios Parasitológicos y de Vectores/CEPAVE, Facultad de Ciencias Naturales y Museo/UNLP, Consejo Nacional de Investigaciones Científicas y Técnicas/CONICET, Boulevard 120, s/n, e/61 y 62 La Plata, Buenos Aires, Argentina.

The fourth instar larva and pupa of Dasyhelea flavifrons Guérin-Méneville are redescribed, illustrated, and photomicrographed using binocular, phase-contrast, and scanning electron microscopy. Comparisons with the American species of the grisea group were made. The immatures were collected by using a siphon bottle in tree-holes and from water collected in dead snail shells in Salta Province, Argentina, transported to the laboratory and there bred to the emergence of the adults. Read More

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http://dx.doi.org/10.1590/0001-3765201920180047DOI Listing

A Computer Application to Predict Adverse Events in the Short-Term Evolution of Patients With Exacerbation of Chronic Obstructive Pulmonary Disease.

JMIR Med Inform 2019 04 17;7(2):e10773. Epub 2019 Apr 17.

Red de Investigación en Servicios Sanitarios en Enfermedades Crónicas, Galdakao, Spain.

Background: Chronic obstructive pulmonary disease (COPD) is a common chronic disease. Exacerbations of COPD (eCOPD) contribute to the worsening of the disease and the patient's evolution. There are some clinical prediction rules that may help to stratify patients with eCOPD by their risk of poor evolution or adverse events. Read More

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http://dx.doi.org/10.2196/10773DOI Listing
April 2019
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High-flow nasal cannula oxygenation reduces postoperative hypoxemia in morbidly obese patients: a randomized controlled trial.

Minerva Anestesiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology & Critical Care, Hospital Clínico Universitario, Valencia, Spain.

Background: Postoperative pulmonary complications (PPCs) are common in high-risk surgical patients. Postoperative ventilatory management may improve their outcomes. Supplemental oxygen through a high-flow nasal cannula (HFNC) has become an alternative to classical oxygenation techniques, although the results published for postoperative patients are contradictory. Read More

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http://dx.doi.org/10.23736/S0375-9393.19.13364-0DOI Listing
April 2019
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Clinical and laboratory features of anti-MAG neuropathy without monoclonal gammopathy.

Sci Rep 2019 Apr 16;9(1):6155. Epub 2019 Apr 16.

Neuromuscular Diseases Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Antibodies against myelin-associated glycoprotein (MAG) almost invariably appear in the context of an IgM monoclonal gammopathy associated neuropathy. Very few cases of anti-MAG neuropathy lacking IgM-monoclonal gammopathy have been reported. We investigated the presence of anti-MAG antibodies in 69 patients fulfilling diagnostic criteria for CIDP. Read More

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http://www.nature.com/articles/s41598-019-42545-8
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http://dx.doi.org/10.1038/s41598-019-42545-8DOI Listing
April 2019
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Cases report: severe colonic bleeding in ulcerative colitis is refractory to selective transcatheter arterial embolization.

BMC Gastroenterol 2019 Apr 16;19(1):55. Epub 2019 Apr 16.

Servicio de Aparato Digestivo. Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, C/ Dr. Esquerdo 46, 28007, Madrid, Spain.

Background: Severe haemorrhage is an uncommon but life-threatening complication of ulcerative colitis (UC). Superselective transcatheter embolization has shown to be an effective and safe therapeutic modality in patients with lower gastrointestinal bleeding of various aetiologies; nevertheless, its role in UC-related acute bleeding is unknown.

Cases Presentation: Efficacy and safety of selective transcatheter arterial embolization in three consecutive UC patients diagnosed with massive haemorrhage admitted in a tertiary institution are reported. Read More

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http://dx.doi.org/10.1186/s12876-019-0970-8DOI Listing

Genotypic diversity of Salmonella ser. Abortusequi isolates from Argentina.

Equine Vet J 2019 Apr 16. Epub 2019 Apr 16.

Instituto Nacional de Tecnología Agropecuaria (INTA), CICVyA, Instituto de Patobiología, Área de Bacteriología, Castelar, Buenos Aires, Argentina.

Background: Salmonella enterica subsp. enterica serovar Abortusequi (S. Abortusequi) is a serotype restricted to equines, which produce abortion outbreaks. Read More

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http://dx.doi.org/10.1111/evj.13123DOI Listing

First outbreak of Oropouche Fever reported in a non-endemic western region of the Peruvian Amazon. Molecular diagnosis and clinical characteristics.

Int J Infect Dis 2019 Apr 13. Epub 2019 Apr 13.

School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Centro de Salud Las Palmas - Red de Salud Leoncio Prado - Ministerio de Salud, Huánuco, Peru. Electronic address:

Introduction: Oropouche fever is an under-reported and emerging infectious disease caused by Oropouche virus (OROV). Its incidence is under-estimated mainly due to clinical similarities with other endemic arboviral diseases and the lack of specific diagnostic tests. We report the first outbreak of Oropouche fever in a western region of the Peruvian Amazon in Huanuco, Peru. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.011DOI Listing

Secundiflorol G isolated from Aeschynomene fascicularis, a Mayan medicinal plant, induces apoptosis in cervical cancer cells.

Nat Prod Res 2019 Apr 16:1-3. Epub 2019 Apr 16.

b Unidad de Investigación Médica Yucatán, Unidad Médica de Alta Especialidad , Centro Médico Ignacio García Téllez, Instituto Mexicano del Seguro Social (IMSS) , Mérida , Yucatan , Mexico.

Secundiflorol G (SG) is an isoflavan isolated from the root bark of Aeschynomene fascicularis, a Mayan medicinal plant used to treat cancer-like symptoms. SG has been shown to have cytotoxic effects on cervical cancer cells (HeLa). Assays were done to identify the mechanisms of SG's cytotoxic effect. Read More

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http://dx.doi.org/10.1080/14786419.2019.1601092DOI Listing
April 2019
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Factors associated with impairment in gait speed in older people with clinically normal gait. A cross-sectional study.

Aging Clin Exp Res 2019 Apr 12. Epub 2019 Apr 12.

Fundación de Investigación Biomédica del Hospital Universitario de Getafe, Getafe, Spain.

Background: Health professionals commonly use gait speed in the evaluation of functional status in older people. However, only a limited number of studies have assessed gait speed in the absence of disorders of gait, using confounding factors and exclusion criteria coming from studies conducted in younger people. Our study aims to analyse which factors are associated with gait speed in older people with normal clinical gait. Read More

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http://link.springer.com/10.1007/s40520-019-01187-6
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http://dx.doi.org/10.1007/s40520-019-01187-6DOI Listing
April 2019
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Lung function measurements in the prediabetes stage: data from the ILERVAS Project.

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Endocrinology and Nutrition Department, Hospital Universitari Vall d'Hebron, Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.

Aims: Patients with type 2 diabetes have been considered a susceptible group for pulmonary dysfunction. Our aim was to assess pulmonary function on the prediabetes stage.

Methods: Pulmonary function was assessed in 4,459 non-diabetic subjects, aged between 45 and 70 years, without cardiovascular disease or chronic pulmonary obstructive disease from the ongoing study ILERVAS. Read More

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http://link.springer.com/10.1007/s00592-019-01333-6
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http://dx.doi.org/10.1007/s00592-019-01333-6DOI Listing
April 2019
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Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer.

Authors:
Manuel A Ferreira Eric R Gamazon Fares Al-Ejeh Kristiina Aittomäki Irene L Andrulis Hoda Anton-Culver Adalgeir Arason Volker Arndt Kristan J Aronson Banu K Arun Ella Asseryanis Jacopo Azzollini Judith Balmaña Daniel R Barnes Daniel Barrowdale Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Katarzyna Białkowska Carl Blomqvist Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Ake Borg Hiltrud Brauch Hermann Brenner Annegien Broeks Barbara Burwinkel Trinidad Caldés Maria A Caligo Daniele Campa Ian Campbell Federico Canzian Jonathan Carter Brian D Carter Jose E Castelao Jenny Chang-Claude Stephen J Chanock Hans Christiansen Wendy K Chung Kathleen B M Claes Christine L Clarke Fergus J Couch Angela Cox Simon S Cross Kamila Czene Mary B Daly Miguel de la Hoya Joe Dennis Peter Devilee Orland Diez Thilo Dörk Alison M Dunning Miriam Dwek Diana M Eccles Bent Ejlertsen Carolina Ellberg Christoph Engel Mikael Eriksson Peter A Fasching Olivia Fletcher Henrik Flyger Eitan Friedman Debra Frost Marike Gabrielson Manuela Gago-Dominguez Patricia A Ganz Susan M Gapstur Judy Garber Montserrat García-Closas José A García-Sáenz Mia M Gaudet Graham G Giles Gord Glendon Andrew K Godwin Mark S Goldberg David E Goldgar Anna González-Neira Mark H Greene Jacek Gronwald Pascal Guénel Christopher A Haiman Per Hall Ute Hamann Wei He Jane Heyworth Frans B L Hogervorst Antoinette Hollestelle Robert N Hoover John L Hopper Peter J Hulick Keith Humphreys Evgeny N Imyanitov Claudine Isaacs Milena Jakimovska Anna Jakubowska Paul A James Ramunas Janavicius Rachel C Jankowitz Esther M John Nichola Johnson Vijai Joseph Beth Y Karlan Elza Khusnutdinova Johanna I Kiiski Yon-Dschun Ko Michael E Jones Irene Konstantopoulou Vessela N Kristensen Yael Laitman Diether Lambrechts Conxi Lazaro Goska Leslie Jenny Lester Fabienne Lesueur Sara Lindström Jirong Long Jennifer T Loud Jan Lubiński Enes Makalic Arto Mannermaa Mehdi Manoochehri Sara Margolin Tabea Maurer Dimitrios Mavroudis Lesley McGuffog Alfons Meindl Usha Menon Kyriaki Michailidou Austin Miller Marco Montagna Fernando Moreno Lidia Moserle Anna Marie Mulligan Katherine L Nathanson Susan L Neuhausen Heli Nevanlinna Ines Nevelsteen Finn C Nielsen Liene Nikitina-Zake Robert L Nussbaum Kenneth Offit Edith Olah Olufunmilayo I Olopade Håkan Olsson Ana Osorio Janos Papp Tjoung-Won Park-Simon Michael T Parsons Inge Sokilde Pedersen Ana Peixoto Paolo Peterlongo Paul D P Pharoah Dijana Plaseska-Karanfilska Bruce Poppe Nadege Presneau Paolo Radice Johanna Rantala Gad Rennert Harvey A Risch Emmanouil Saloustros Kristin Sanden Elinor J Sawyer Marjanka K Schmidt Rita K Schmutzler Priyanka Sharma Xiao-Ou Shu Jacques Simard Christian F Singer Penny Soucy Melissa C Southey John J Spinelli Amanda B Spurdle Jennifer Stone Anthony J Swerdlow William J Tapper Jack A Taylor Manuel R Teixeira Mary Beth Terry Alex Teulé Mads Thomassen Kathrin Thöne Darcy L Thull Marc Tischkowitz Amanda E Toland Diana Torres Thérèse Truong Nadine Tung Celine M Vachon Christi J van Asperen Ans M W van den Ouweland Elizabeth J van Rensburg Ana Vega Alessandra Viel Qin Wang Barbara Wappenschmidt Jeffrey N Weitzel Camilla Wendt Robert Winqvist Xiaohong R Yang Drakoulis Yannoukakos Argyrios Ziogas Peter Kraft Antonis C Antoniou Wei Zheng Douglas F Easton Roger L Milne Jonathan Beesley Georgia Chenevix-Trench

Nat Commun 2019 Apr 15;10(1):1741. Epub 2019 Apr 15.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.

Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. Read More

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http://dx.doi.org/10.1038/s41467-018-08053-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465407PMC
April 2019
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Precision medicine in obstructive sleep apnoea.

Lancet Respir Med 2019 Apr 12. Epub 2019 Apr 12.

Centro de Investigación Biomédica en Red Enfermedades Respiratorias, Madrid, Spain; Paediatric Department, Institut Respiratori, Hospital Clinic Barcelona, Barcelona, Spain; Respiratory Department, University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

Obstructive sleep apnoea (OSA) is a heterogeneous and complex disease; however, diagnosis and management still rely on a simple set of tools and few therapeutic options. Precision medicine has emerged as the next goal for clinical practice, with the objective being to offer individually tailored treatments. Ways of implementing precision medicine in clinical practice have emerged for various respiratory disorders, and such an approach could also be readily exported to OSA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132600193004
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http://dx.doi.org/10.1016/S2213-2600(19)30044-XDOI Listing
April 2019
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Consensus on the prevention, diagnosis, and treatment of Clostridium difficile infection.

Rev Gastroenterol Mex 2019 Apr 12. Epub 2019 Apr 12.

Hospital Ángeles y Hospital Lomas, San Luis Potosí, S.L.P., México. Electronic address:

In recent decades, Clostridium difficile infection (CDI) has become a worldwide health problem. Mexico is no exception, and therefore the Asociación Mexicana de Gastroenterología brought together a multidisciplinary group (gastroenterologists, endoscopists, internists, infectious disease specialists, and microbiologists) to carry out the "Consensus on the prevention, diagnosis, and treatment of Clostridium difficile infection", establishing useful recommendations (in relation to the adult population) for the medical community. Said recommendations are presented herein. Read More

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http://dx.doi.org/10.1016/j.rgmx.2018.12.001DOI Listing
April 2019
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Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells.

BMC Cancer 2019 Apr 15;19(1):356. Epub 2019 Apr 15.

Departamento de Medicina Genomica y Toxicologia Ambiental, Instituto de Investigaciones Biomedicas (IIBO), Universidad Nacional Autonoma de Mexico (UNAM), 04510 Ciudad de Mexico (CDMX), Mexico, Mexico.

Background: Glucocorticoid receptor (GR) activation has been associated with breast cancer cell survival in vitro. Glucocorticoid (GC)-dependent protection against tumor necrosis factor (TNF)-induced cell death has been well characterized in MCF7 luminal A breast cancer cells. The GR activates a variety of protective mechanisms, such as inhibitors of apoptosis proteins (IAPs). Read More

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http://dx.doi.org/10.1186/s12885-019-5563-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466787PMC
April 2019
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