4,319 results match your criteria Endophthalmitis Fungal

Long-Term Outcomes of Boston Type I Keratoprosthesis, and Efficacy of Amphotericin B and Povidone-Iodine in Infection Prophylaxis.

Am J Ophthalmol 2021 Jun 5. Epub 2021 Jun 5.

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University 2 Wanglang Road, Bangkok Noi, Bangkok 10700, Thailand.

Purpose: To evaluate the long-term outcomes, anatomical retention and complications of Boston type I keratoprosthesis (KPro).

Design: Retrospective, interventional case series.

Methods: A retrospective chart review of implantations performed January 2008-December 2017 was conducted. Read More

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Immune Inhibitor A Metalloproteases Contribute to Virulence in Endophthalmitis.

Infect Immun 2021 Jun 7:IAI0020121. Epub 2021 Jun 7.

Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Endophthalmitis is a devastating infection that can cause blindness. Over half of endophthalmitis cases result in significant loss of useful vision. produces many virulence factors that may contribute to retinal damage and robust inflammation. Read More

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Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection.

Cell Rep Med 2021 May 18;2(5):100277. Epub 2021 May 18.

Department of Ophthalmology, Visual and Anatomical Sciences, Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA.

The eye is highly susceptible to inflammation-mediated tissue damage evoked during bacterial infection. However, mechanisms regulating inflammation to protect the eye remain elusive. Here, we used integrated metabolomics and transcriptomics to show that the immunomodulatory metabolite itaconate and immune-responsive gene 1 () are induced in bacterial ()-infected mouse eyes, bone-marrow-derived macrophages (BMDMs), and Müller glia. Read More

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Practical Guidance for Clinical Microbiology Laboratories: Diagnosis of Ocular Infections.

Clin Microbiol Rev 2021 Jun 2:e0007019. Epub 2021 Jun 2.

Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

The variety and complexity of ocular infections have increased significantly in the last decade since the publication of , (L. D. Gray, P. Read More

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Biofilm-Forming Potential of Ocular Fluid and on Ex Vivo Human Corneas from Attachment to Dispersal Phase.

Microorganisms 2021 May 22;9(6). Epub 2021 May 22.

Jhaveri Microbiology Centre, Prof. Brien Holden Eye Research Centre, Kallam Anji Reddy Campus, L. V. Prasad Eye Institute, Hyderabad 500034, Telangana, India.

The biofilm-forming potential of and , isolated from patients with Endophthalmitis, was monitored using glass cover slips and cadaveric corneas as substrata. Both the ocular fluid isolates exhibited biofilm-forming potential by the Congo red agar, Crystal violet and 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-(phenylamino) carbonyl-2H-tetra-zolium hydroxide (XTT) methods. Confocal microscopy demonstrated that the thickness of the biofilm increased from 4-120 h of biofilm formation. Read More

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Post-traumatic exogenous endophthalmitis caused by Nocardia farcinica.

J Ophthalmic Inflamm Infect 2021 Jun 1;11(1):16. Epub 2021 Jun 1.

Department of Ophthalmology, Charles University, 2nd Faculty of Medicine and University Hospital in Motol, Prague, Czech Republic.

A case report of post-traumatic exogenous endophthalmitis caused by Nocardia farcinica, including treatment procedures, microbiology examination, and systemic medications. A 23-year-old male suffered a penetrating corneal injury that was treated with sutures. On the thirteenth day after the final suture was removed, an anterior uveitis developed and progressed to whitish, plump, nodular, and tufted exudates within the anterior chamber over the next 10 days; this led to an indication for intraocular surgery. Read More

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Susceptibility of severe COVID-19 patients to rhino-orbital mucormycosis fungal infection in different clinical manifestations.

Jpn J Ophthalmol 2021 May 31. Epub 2021 May 31.

Department of Otorhinolaryngology-Head and Neck Surgery, Kayseri City Training and Research Hospital, University of Health Science, Kayseri, Turkey.

Purpose: To present the different clinical manifestations of rhino-orbital mucormycosis (ROM) co-infection in severe COVID-19 patients.

Study Design: Prospective observational clinical study METHODS: Among 32,814 patients hospitalized with the diagnosis of COVID-19 between March 2020 and December 2020 in our center, eleven microbiologically confirmed ROM co-infection cases in severe COVID-19 patients were evaluated.

Results: There were nine men and two women with a mean age of 73. Read More

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An 18-Year Overview of Serratia marcescens Ocular Infection.

Eye Contact Lens 2021 May 25. Epub 2021 May 25.

Department of Ophthalmology (S.A., R.P.K., V.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Ophthalmology (C.P.), Stanford University School of Medicine, Stanford, CA; and The Charles T. Campbell Ophthalmic Microbiology Laboratory (S.N., R.P.K., V.J.), University of Pittsburgh Medical Center, Pittsburgh, PA.

Purpose: Serratia marcescens is a frequent ocular bacterial pathogen implicated in keratitis, endophthalmitis, and conjunctivitis. We evaluated the risk factors and treatment outcomes of ocular infections due to S. marcescens. Read More

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Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand.

Sci Rep 2021 May 27;11(1):11217. Epub 2021 May 27.

Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Road, Prannok, Bangkok-noi, Bangkok, 10700, Thailand.

To demonstrate the demographics, associated factors, clinical presentations, microbiology, management, visual outcome and complications of keratitis/scleritis-related endophthalmitis (KSE). A retrospective chart of all endophthalmitis patients diagnosed between September 2001 and August 2011 was reviewed. Only endophthalmitis cases with previous corneal or scleral infection were included in the study. Read More

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The virulome in endophthalmitis.

Microbiology (Reading) 2021 May;167(5)

Dean McGee Eye Institute, Oklahoma City, Oklahoma, USA.

is recognized as a causative agent of gastrointestinal syndromes, but can also cause a devastating form of intraocular infection known as endophthalmitis. We have previously reported that the PlcR/PapR master virulence factor regulator system regulates intraocular virulence, and that the S-layer protein (SlpA) contributes to the severity of endophthalmitis. To better understand the role of other virulence genes in endophthalmitis, expression of a subset of factors was measured at the midpoint of disease progression in a murine model of endophthalmitis by RNA-Seq. Read More

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Evaluation of vitreous Procalcitonin as a diagnostic biomarker in infectious endophthalmitis.

Int Ophthalmol 2021 May 24. Epub 2021 May 24.

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, Telangana, 500034, India.

Background: Endophthalmitis is a potentially blinding intraocular infection following intraocular surgery or trauma. Prompt diagnosis and treatment are important in preventing devastating visual complications. Procalcitonin (PCT) is a promising biomarker for diagnosing bacterial infections. Read More

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Steroid induced Pseudomonas aeruginosa endophthalmitis outbreak.

J Cataract Refract Surg 2021 May 18. Epub 2021 May 18.

Department of Ophthalmology (Guru Nanak Eye Centre), Maulana Azad Medical College, New Delhi, India Department of Microbiology, G B Pant hospital, New Delhi, India.

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Fusarium infection complicating rheumatic keratitis that acutely progressed to endophthalmitis during regular infusion of tocilizumab: a case report.

BMC Ophthalmol 2021 May 19;21(1):224. Epub 2021 May 19.

Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Background: Filamentous fungi are ubiquitous in plants, water, and soil. The predominant fungi that infect the human cornea include Fusarium and Aspergillus species. The onset of fungal endophthalmitis is indolent, and typically takes weeks to months to develop after corneal infection. Read More

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Rapid Whole Genome Sequencing of Serotype K1 Hypervirulent from an Undocumented Chinese Migrant.

Case Rep Infect Dis 2021 28;2021:6638780. Epub 2021 Apr 28.

Department of Medicine, University of Cambridge, Cambridge, UK.

Background: Hypervirulent causes severe disseminated infections, typically with hepatic and central nervous system involvement including endophthalmitis. . We report a fatal case of an undocumented Chinese migrant in her 60s who presented to the emergency department with abdominal pain, lethargy, and headache over the preceding two weeks. Read More

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Targeted metagenomics using next generation sequencing in laboratory diagnosis of culture negative endophthalmitis.

Heliyon 2021 Apr 23;7(4):e06780. Epub 2021 Apr 23.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

To study the feasibility of 16S rRNA metagenomics using next generation sequencing (NGS) along with broad range PCR assay for 762 bp region of 16S rRNA gene with Sanger's sequencing, in microbial diagnosis of culture negative endophthalmitis. Vitreous fluid from 16 culture negative and one culture positive endophthalmitis patients, admitted to a tertiary care hospital were processed for targeted metagenomics. NGS of 7 variable regions of 16S rRNA gene was done using Ion Torrent Personal Genome Machine (PGM). Read More

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First report of human infection caused by occurring in a post-corneal transplant patient with endophthalmitis.

Med Mycol Case Rep 2021 Jun 21;32:73-76. Epub 2021 Apr 21.

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, NY, USA.

Keratomycosis or mycotic keratitis is recognized as one of the major causes of ophthalmic morbidity worldwide. The most common organisms linked to keratomycosis include spp., spp. Read More

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Intraocular penetration of liposomal amphotericin B after intravenous injection in inflamed human eyes.

J Infect Chemother 2021 May 11. Epub 2021 May 11.

Medical Mycology Research Center, Chiba University, Chiba, Japan.

Purpose: To determine the intraocular penetration of amphotericin B (AMPH-B) after an intravenously injection of liposomal amphotericin B (L-AMB) in inflamed human eyes.

Methods: Seven eyes of 5 patients with fungal eye diseases (endophthalmitis in 6 eyes and keratitis in 1 eye) were treated with intravenous injections of 100-250 mg/day of L-AMB. Samples of blood, corneal button, aqueous humor, and vitreous humor were collected and assessed for AMPH-B. Read More

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Microbiological patterns of endophthalmitis in a tertiary level hospital of Kathmandu, Nepal.

Nepal J Ophthalmol 2020 Jul;12(24):262-269

Tilganga Institute of Ophthalmology, Gaushala, Kathmandu, Nepal.

Introduction: Endophthalmitis is a serious ocular infection that can result in blindness and therefore is a major ophthalmic concern. The study was conducted to find out the microbial etiology in clinically diagnosed cases of endophthalmitis and to determine the antibacterial susceptibilities of bacterial isolates in vitro.

Materials And Methods: A retrospective analysis was carried out of all patients presenting between 15th January 2012 to 15th January 2013 with clinically diagnosed Endophthalmitis at Tilganga Institute of Ophthalmology (TIO). Read More

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Early postoperative infection following lamellar keratoplasty: a review.

Br J Ophthalmol 2021 May 3. Epub 2021 May 3.

Cornea & Anterior Segment Service, LV Prasad Eye Institute, Bhubaneswar, Odisha, India

With the growing popularity of lamellar keratoplasty for selective replacement of diseased corneal tissue, it is important to understand the risk of developing an infection after the procedure. Although lesser than that postpenetrating keratoplasty, the reports on post lamellar keratoplasty infectious keratitis are not negligible. Trends of acute infections arising within 2 months of surgery are a subject of interest. Read More

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Microbial diagnosis of endophthalmitis using nanopore amplicon sequencing.

Int J Med Microbiol 2021 May 20;311(4):151505. Epub 2021 Apr 20.

Department of Neurology, Seoul National University Hospital, Seoul, South Korea; Department of Genomic Medicine, Seoul National University Hospital, Seoul, South Korea. Electronic address:

Objectives: We investigated whether nanopore amplicon sequencing of aqueous humor was capable of rapid pathogen identification in infectious endophthalmitis.

Methods: 5 cases of culture-positive bacterial endophthalmitis and 3 cases of fungal endophthalmitis (1 culture-positive and 2 presumed) were included. DNA was extracted from the aqueous humor and vitreous specimen, and PCR of bacterial rDNA (16S) and fungal rDNA (ITS1 and D1/2/3) was performed. Read More

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A case series of presumed fungal endogenous endophthalmitis in post COVID-19 patients.

Indian J Ophthalmol 2021 May;69(5):1322-1325

Department of Uvea and Intraocular Inflammation, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

The novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, has challenged the medical community. Several ocular manifestations secondary to COVID-19 have been documented. Prolonged hospitalization exposes the patient to various multiresistant bacteria making them prone to various secondary infections. Read More

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Retrospective multifactorial analysis of and review of literature.

Indian J Ophthalmol 2021 05;69(5):1095-1101

Department of Microbiology, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Cuddalore Main Road, Thavalukuppam, Pondicherry, India.

Purpose: The aim of this work was to study the demographic profile, clinical diagnostic features, challenges in management, treatment outcomes, and ocular morbidity of microbiological culture-proven Pythium keratitis in a tertiary eye care hospital in South India.

Methods: Retrospective analysis of microbiologically proven Pythium keratitis patients was performed at a tertiary eye center from October 2017 to March 2020. Demographic details, risk factors, microbiological investigations, clinical course, and visual outcomes were analyzed. Read More

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Rare case of endogenous Klebsiella endophthalmitis associated with emphysematous prostatitis in a patient with diabetes, cirrhosis and COVID-19.

BMJ Case Rep 2021 Apr 21;14(4). Epub 2021 Apr 21.

Internal Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

A 35-year-old Hispanic man presented with fever, chills, dysuria, diarrhoea, scleral icterus, tachycardia and tachypnea. He was found to be COVID-19 positive, CT of the pelvis revealed prostatic abscess, and urine culture grew Additionally, he was found to have diabetes and cirrhosis. During treatment, the patient developed vision loss, and was diagnosed with endogenous Klebsiella endophthalmitis. Read More

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Differential inflammatory response to Aspergillus flavus and Candida albicans infection in human retinal pigment epithelial cells: Role in treatment of endophthalmitis.

J Mycol Med 2021 Apr 3;31(3):101136. Epub 2021 Apr 3.

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana 500034 , India. Electronic address:

Objective: Fungal endophthalmitis is an emerging vision-threatening complication in tropical countries and the Retinal pigment epithelial cells (RPE) are said to play a major role in the retinal pathology. The aim of this study was to compare the immune response of Retinal pigment epithelial cells (RPE) challenged with A. flavus and C. Read More

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Clinical course, treatment and visual outcome of an outbreak of Burkholderia contaminans endophthalmitis following cataract surgery.

J Ophthalmic Inflamm Infect 2021 Apr 19;11(1):12. Epub 2021 Apr 19.

Department of Ophthalmology, University Hospital of North Norway, Tromsø, Norway.

Background: Postoperative endophthalmitis is a rare but dreaded complication of intraocular surgery and often results in severe visual impairment or blindness. The present study describes the clinical course, treatment and visual outcome of an outbreak of Burkholderia contaminans endophthalmitis following cataract surgery.

Methods: Among 290 patients who underwent uneventful phacoemulsification cataract surgery at one outpatient clinic between January 4th and 28th 2019, 6 cases developed Burkholderia contaminans endophthalmitis. Read More

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Genomic and phenotypic diversity of Enterococcus faecalis isolated from endophthalmitis.

PLoS One 2021 14;16(4):e0250084. Epub 2021 Apr 14.

Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

Enterococcus faecalis are hospital-associated opportunistic pathogens and also causative agents of post-operative endophthalmitis. Patients with enterococcal endophthalmitis often have poor visual outcomes, despite appropriate antibiotic therapy. Here we investigated the genomic and phenotypic characteristics of E. Read More

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Chronic endogenous fungal endophthalmitis: diagnostic and treatment challenges: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25459

Department of Ophthalmology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Malaysia.

Rationale: Endogenous fungal endophthalmitis (EFE) is a sight-threatening complication of systemic fungemia. As the prevalence rises, treatment remains a challenge especially when there is a failure in first-line treatment or drug-resistant fungus. This case report studies a case of chronic EFE, focusing on the diagnostic procedures, treatment options, monitoring parameters and the treatment outcome. Read More

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Endogenous Endophthalmitis: A 21-Year Review of Cases at a Tertiary Eye Care Centre.

Ocul Immunol Inflamm 2021 Apr 7:1-6. Epub 2021 Apr 7.

Department of Ophthalmology, Greenlane Clinical Centre, Auckland, New Zealand.

: Endogenous endophthalmitis is rare and associated with significant morbidity and mortality. The primary objective was to identify causative organisms. Secondary objectives included the determination of systemic risk factors and visual prognostic factors. Read More

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Incidence and outcomes of endophthalmitis with in-house compounded intravitreal bevacizumab injections: A multicentric study.

Semin Ophthalmol 2021 Mar 22:1-10. Epub 2021 Mar 22.

Department of Microbiology, Aravind Eye Hospital, Madurai, India.

: To evaluate the incidence rate and outcomes of endophthalmitis after intravitreal injection of in-house compounded bevacizumab.: In this multicentric study performed from 2014 to 2018, patients who were injected with in-house compounded and sterilized bevacizumab were observed for endophthalmitis. In-house compounded syringes were prepared in compounding pharmacy using sterile standard operating guidelines. Read More

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Post-Traumatic Endophthalmitis: Clinico-Microbiological Profile, Antimicrobial Susceptibility and Prognostic Factors at a Tertiary Eye Care Centre in Eastern India.

Semin Ophthalmol 2021 Mar 22:1-9. Epub 2021 Mar 22.

Retina and Uveitis Services, LV Prasad Eye Institute, Mithu Tulsi Chanrai Campus, Bhubaneswar, India.

: To analyse clinico-microbiological profile, antimicrobial susceptibilities, and visual prognostic factors in post-traumatic endophthalmitis (PTE).: Retrospective clinico-microbiological data analysis for five years (2014-18). Prognostic factors for visual outcomes were analysed by multivariate logistic regression analysis. Read More

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