3,899 results match your criteria Endophthalmitis Fungal


endophthalmitis in a Cuban pediatric patient.

SAGE Open Med Case Rep 2019 30;7:2050313X19827403. Epub 2019 Jan 30.

Pedro Kourí Tropical Medicine Institute, La Habana, Cuba.

Bacterial endophthalmitis is the most severe form of vision-threatening ocular infection. is a primary respiratory pathogen that has been associated with several extrapulmonary manifestation, including ocular infection. In this work, we presented the microbiology diagnosis of an endophalmitis by using a novel A. Read More

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http://dx.doi.org/10.1177/2050313X19827403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354299PMC
January 2019

New insights into culture negative endophthalmitis by unbiased next generation sequencing.

Sci Rep 2019 Jan 29;9(1):844. Epub 2019 Jan 29.

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

The proof-of-concept, study to investigate the presence of microorganisms in presumed infectious endophthalmitis using Next generation sequencing (NGS) was carried out in vitreous biopsies from 34 patients with endophthalmitis, and thirty patients undergoing surgery for non-infectious retinal disorders as controls. Following DNA extraction using the Qiagen mini kit and PCR amplification of the V3-V4 regions of the bacterial 16S rRNA and ITS 2 region of fungus, they samples were sequenced on an Illumina HiSeq 2500 Machine. Paired reads were curated, taxonomically labeled, and filtered. Read More

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http://www.nature.com/articles/s41598-018-37502-w
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http://dx.doi.org/10.1038/s41598-018-37502-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351655PMC
January 2019
3 Reads

ENTEROCOCCUS ENDOPHTHALMITIS: Clinical Settings, Antimicrobial Susceptibility, and Management Outcomes.

Retina 2019 Jan 23. Epub 2019 Jan 23.

Srimati Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: To report the clinical presentation and management outcome of patients with endophthalmitis caused by Enterococcus species and to report the susceptibility profile of the isolates.

Methods: Twenty-nine cases with culture-proven Enterococcus endophthalmitis from January 2005 to May 2018 underwent vitrectomy/vitreous biopsy, intravitreal antibiotic with or without additional procedures. The undiluted vitreous was subjected to microbiologic evaluation. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002462DOI Listing
January 2019
3.243 Impact Factor

Post-Traumatic Endophthalmitis due to Acinetobacter radioresistens: Virulence Potential of Commensal Bacteria.

Infect Disord Drug Targets 2019 Jan 23. Epub 2019 Jan 23.

Department of Microbiology, Government Medical College and Hospital, Sector 32, Chandigarh. India.

Acinetobacter species are widely distributed in soil, water and hospital environment. In addition to A. calcoaceticus-baumannii complex, the clinically most relevant species, there are other genomospecies which are less frequently identified, mostly due to lack of accurate methods for routine identification. Read More

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http://dx.doi.org/10.2174/1871526519666190123145321DOI Listing
January 2019
3 Reads

ACUTE MYOCARDITIS WITH CARDIOGENIC SHOCK AND MULTIPLE ORGAN FAILURE, FOLLOWED BY BILATERAL PANUVEITIS MASQUERADING AS ENDOGENOUS ENDOPHTHALMITIS, DUE TO TOXOPLASMA GONDII IN AN IMMUNOCOMPETENT PATIENT.

Retin Cases Brief Rep 2019 Jan 17. Epub 2019 Jan 17.

Massachusetts Eye Research and Surgery Institution (MERSI), Waltham, Massachusetts.

Purpose: To report a case of systemic and ocular toxoplasmosis in an immunocompetent patient, who developed myocarditis with resulting cardiogenic shock and multiple organ failure, followed by bilateral panuveitis masquerading as endogenous endophthalmitis.

Methods: Single case report with images.

Results: A 59-year-old man with a history of monoclonal gammopathy of undetermined significance and associated scleromyxedema but otherwise immunocompetent was admitted to the intensive care unit for cardiogenic shock and multiple organ failure due to presumed viral myocarditis. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000855DOI Listing
January 2019
4 Reads

Postoperative Mycobacteroides abscessus subsp. abscessus endophthalmitis: Clinical analysis of 12 clustered adults and a proposed therapeutic algorithm.

J Microbiol Immunol Infect 2019 Jan 6. Epub 2019 Jan 6.

Department of Ophthalmology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, College of Medicine, Taipei Medical University, Taiwan. Electronic address:

Purpose: Postoperative endophthalmitis caused by nontuberculous mycobacterium is a rare but devastating complication after intraocular surgery. However, optimal treatment strategies remain undetermined in view of its rarity.

Methods: We investigated the cases of culture-proven postoperative Mycobacteroides abscessus subsp. Read More

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http://dx.doi.org/10.1016/j.jmii.2018.12.011DOI Listing
January 2019
1 Read

Culture-Proven Endophthalmitis After Intravitreal Injection: A 10-Year Analysis.

Ophthalmic Surg Lasers Imaging Retina 2019 Jan;50(1):33-38

Background And Objective: To report on the microbiology, management, and visual outcomes of intravitreal injection (IVI)-associated, culture-proven endophthalmitis.

Patients And Methods: All patients seen at a tertiary referral center with culture-proven endophthalmitis associated with an IVI between June 2007 and July 2017 were included in this retrospective analysis.

Results: Thirty-five patients with culture-positive endophthalmitis following IVI were identified. Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2018
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http://dx.doi.org/10.3928/23258160-20181212-05DOI Listing
January 2019
4 Reads

Effect of time to primary repair on final visual outcome after open globe injury.

Br J Ophthalmol 2019 Jan 12. Epub 2019 Jan 12.

Academic Unit of Ophthalmology, Birmingham and Midland Eye Centre, City Hospital, Birmingham, UK.

Background/aim: Historic data suggest that open globe injuries should be repaired within 12-24 hours to reduce the risk of endophthalmitis. However, endophthalmitis is uncommon when systemic antibiotic prophylaxis is given. It is not clear whether delayed primary repair impacts visual outcomes in other ways or what is the optimum time to repair. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2017-3115
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http://dx.doi.org/10.1136/bjophthalmol-2017-311559DOI Listing
January 2019
10 Reads

Ocular infection caused by Hormographiella aspergillata: A case report and review of literature.

J Mycol Med 2019 Jan 7. Epub 2019 Jan 7.

Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Hormographiella aspergillata, a basidiomycete is a rare cause of human infection. We report a case of 70-year-old female with corneal ulcer and endophthalmitis caused by this agent. The patient had an intraocular implantation of lens following a cataract surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11565233183024
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http://dx.doi.org/10.1016/j.mycmed.2018.12.002DOI Listing
January 2019
6 Reads

Diagnosis of Vitreoretinal Aspergillosis with Transvitreal Retinochoroidal Biopsy.

Case Rep Ophthalmol Med 2018 2;2018:8306163. Epub 2018 Dec 2.

Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA, USA.

Diagnosing culture-proven endophthalmitis is complicated by the insufficient yield of intraocular samples and the variety of etiologies which mimic true endophthalmitis. In cases of impending vision loss where vitreous biopsy cannot provide a definitive diagnosis, transvitreal retinochoroidal biopsy can be an effective next step. Our case is a 48-year-old male with B-cell acute lymphoblastic leukemia that presented with counting fingers vision, redness, and tearing of the left eye. Read More

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http://dx.doi.org/10.1155/2018/8306163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304639PMC
December 2018
8 Reads

Antibiotic susceptibility, cytotoxicity, and protease activity of viridans group streptococci causing endophthalmitis.

PLoS One 2018 21;13(12):e0209849. Epub 2018 Dec 21.

Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.

The viridans group streptococci comprise multiple species and have gained more recognition in recent years as common etiologic agents of bacterial endophthalmitis. The purpose of this study was to identify the species of human endophthalmitis isolates of viridans streptococci and to characterize their potential virulence attributes. The species of 22 endophthalmitis strains of viridans streptococci were identified by Matrix Assisted Laser Desorption Ionization Time-of-Flight. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209849PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303072PMC
December 2018
8 Reads

Fungal infection after endothelial keratoplasty: association with hypothermic corneal storage.

Br J Ophthalmol 2018 Dec 18. Epub 2018 Dec 18.

Corneal Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK

Purpose: To compare the incidence of fungal infection after endothelial keratoplasty (EK) when donor tissue had been stored in hypothermic medium or organ culture.

Methods: We describe the clinical features of 10 cases of fungal infection (keratitis or endophthalmitis) following EK identified at three European centres. Case definition was the culture of fungus or a positive PCR from the host cornea or anterior chamber after EK. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312709DOI Listing
December 2018
2 Reads

Unilateral endogenous fungal endophthalmitis after esophageal cancer surgery: a case report.

BMC Infect Dis 2018 Dec 18;18(1):671. Epub 2018 Dec 18.

Department of Ophthalmology, Ningbo Eye Hospital, 855 Minan Road, Ningbo, 315040, China.

Background: This study reports a case of Unilateral Endogenous Fungal Endophthalmitis After Esophageal Cancer Surgery.

Case Presentation: One patient presented with a month-long loss of vision in his left eye, he had surgery for esophageal cancer 2 months earlier. The patient underwent cataract surgery (by phacoemulsification) in the left eye combined with 25-gauge vitrectomy and silicone oil tamponade. Read More

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http://dx.doi.org/10.1186/s12879-018-3607-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299646PMC
December 2018

Endogenous endophthalmitis caused by a multidrug-resistant hypervirulent Klebsiella pneumoniae strain belonging to a novel single locus variant of ST23: first case report in China.

BMC Infect Dis 2018 Dec 17;18(1):669. Epub 2018 Dec 17.

Department of Respiratory Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: Endogenous endophthalmitis caused by hypervirulent Klebsiella pneumoniae (HVKP) is an emerging infectious disease commonly with a devastating visual outcome. Most HVKP strains display a wild-type susceptibility profile to antibiotics. However, reports of antimicrobial-resistant HVKP have increased over time, which poses a serious therapeutic dilemma. Read More

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http://dx.doi.org/10.1186/s12879-018-3543-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296127PMC
December 2018

The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases.

Interdiscip Perspect Infect Dis 2018 13;2018:2525173. Epub 2018 Nov 13.

Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

is a gram-positive, facultatively anaerobic pathogen that can cause severe infections such as pneumonia, meningitis, septicemia, and middle ear infections. It is also one of the top pathogens contributing to bacterial keratitis and conjunctivitis. Though two pneumococcal vaccines exist for the prevention of nonocular diseases, they do little to fully prevent ocular infections. Read More

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https://www.hindawi.com/journals/ipid/2018/2525173/
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http://dx.doi.org/10.1155/2018/2525173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257906PMC
November 2018
4 Reads

A Review of Antimicrobial Therapy for Infectious Uveitis of the Posterior Segment.

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(4):140-155

UCL Institute of Ophthalmology, Moorfields Eye Hospital, London, UK.

Treatment of infectious posterior uveitis represents a therapeutic challenge for ophthalmologists. The eye is a privileged site, maintained by blood ocular barriers, which limits penetration of systemic antimicrobials into the posterior segment. In addition, topical and subconjunctival therapies are incapable of producing sufficient drug concentrations, intraocularly. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6229674PMC
January 2018
3 Reads

Challenges in the Polyene- and Azole-Based Pharmacotherapy of Ocular Fungal Infections.

J Ocul Pharmacol Ther 2019 Jan/Feb;35(1):6-22. Epub 2018 Nov 8.

1 Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, Oxford, Mississippi.

Polyenes and azoles constitute 2 major drug classes in the antifungal armamentarium used to treat fungal infections of the eye such as fungal keratitis, endophthalmitis, conjunctivitis, and blepharitis. These classes of drugs have come to occupy an important niche in ophthalmic antifungal therapy due to their broad spectrum of activity against a variety of filamentous and yeast-like fungi. Natamycin suspension (Natacyn), a polyene antifungal drug, is currently the only US FDA-approved formulation for treating ophthalmic fungal infections, whereas the other polyene and azole antifungals such as amphotericin B, fluconazole, itraconazole, ketoconazole, miconazole, voriconazole, and posaconazole are routinely used off-label in the clinical setting. Read More

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http://dx.doi.org/10.1089/jop.2018.0089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354613PMC
November 2018
17 Reads

The role of pars plana vitrectomy in the management of fungal endogenous endophthalmitis.

Eur J Ophthalmol 2018 Nov 26:1120672118815105. Epub 2018 Nov 26.

Department of Ophthalmology, School of Medicine, Marmara University, Istanbul, Turkey.

Purpose:: To identify the causative microorganism of fungal endogenous endophthalmitis in our tertiary referral uveitis center and review the therapeutic role of pars plana vitrectomy in patients with fungal endogenous endophthalmitis.

Methods:: Seven eyes of six cases were identified as fungal endogenous endophthalmitis through positive cultures of ocular fluids and clinical presentations. The final anatomical and functional results were evaluated. Read More

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http://dx.doi.org/10.1177/1120672118815105DOI Listing
November 2018
7 Reads

Clinical presentations, management outcomes, and diagnostic dilemma in Kocuria endophthalmitis.

J Ophthalmic Inflamm Infect 2018 Nov 20;8(1):21. Epub 2018 Nov 20.

Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, Telangana, 500034, India.

Aim: To describe the clinical presentations and management outcomes of Kocuria endophthalmitis and discuss diagnostic dilemmas DESIGN: Retrospective interventional comparative case series INTERVENTION: Eight unilateral cases with culture-proven Kocuria endophthalmitis from January 2013 to December 2017 underwent vitrectomy/vitreous biopsy and intravitreal antibiotic with or without additional procedures. The undiluted vitreous was subjected to microbiologic evaluation.

Main Outcome Measures: The mean age at presentation, etiology, number of interventions, interval between inciting event and presentation, type of intravitreal antibiotic used, and anatomic and functional outcomes were reported. Read More

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http://dx.doi.org/10.1186/s12348-018-0163-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246755PMC
November 2018
8 Reads

Cluster endophthalmitis due to following intravitreal bevacizumab: outcomes of patients from North India.

Br J Ophthalmol 2018 Nov 12. Epub 2018 Nov 12.

Advanced Eye Center, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Purpose: To study features, management and outcomes of cluster endophthalmitis following intravitreal bevacizumab (BCZ) injection in North India.

Methods: In this retrospective study, 28 patients (23 men) (mean age of 59.07±13 years) who received intravitreal injection of BCZ were included. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3131
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http://dx.doi.org/10.1136/bjophthalmol-2018-313131DOI Listing
November 2018
7 Reads

CLINICAL PRESENTATIONS, DIAGNOSIS, AND MANAGEMENT OUTCOMES OF CURVULARIA ENDOPHTHALMITIS AND A REVIEW OF LITERATURE.

Retina 2018 Oct 23. Epub 2018 Oct 23.

Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, LV Prasad Eye Institute, Hyderabad, India.

Purpose: To describe the clinical presentation and management of Curvularia endophthalmitis and compare with previous published literature.

Methods: Retrospective interventional comparative case series and literature review. Eight cases with culture-proven Curvularia endophthalmitis from January 2000 to March 2018 underwent vitrectomy/vitreous biopsy, intravitreal antibiotic with or without additional procedures as appropriate. Read More

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http://Insights.ovid.com/crossref?an=00006982-900000000-9631
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http://dx.doi.org/10.1097/IAE.0000000000002375DOI Listing
October 2018
7 Reads

Identification of Species in a Patient with Endophthalmitis following Penetrating Injury with Retained Intraocular Metallic Foreign Body.

Case Rep Infect Dis 2018 25;2018:3027846. Epub 2018 Sep 25.

Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.

To the best of our knowledge, we report the first case of species in a patient with endophthalmitis. A 47-year-old man presented to the ophthalmology department with decreased vision, redness, and minimal pain in his right eye after a foreign body struck his eye following working using a hammer and chisel. Broad-spectrum polymerase chain reaction (PCR) and deoxyribonucleic acid (DNA) sequencing targeting 16S ribosomal ribonucleic acid-(rRNA-) encoding gene on an undiluted vitreous sample revealed 100% identity with GenBank sequences of species including , , and . Read More

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https://www.hindawi.com/journals/criid/2018/3027846/
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http://dx.doi.org/10.1155/2018/3027846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176285PMC
September 2018
12 Reads

Interface infectious keratitis after anterior and posterior lamellar keratoplasty. Clinical features and treatment strategies. A review.

Br J Ophthalmol 2018 Oct 24. Epub 2018 Oct 24.

Ophthalmology Unit, Azienda USL - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Interface infectious keratitis (IIK) is a novel corneal infection that may develop after any type of lamellar keratoplasty. Onset of infection occurs in the virtual space between the graft and the host where it may remain localised until spreading with possible risk of endophthalmitis. A literature review identified 42 cases of IIK. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3129
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http://dx.doi.org/10.1136/bjophthalmol-2018-312938DOI Listing
October 2018
8 Reads

Genetic diversity and persistent colonization of Enterococcus faecalis on ocular surfaces.

Jpn J Ophthalmol 2018 Nov 15;62(6):699-705. Epub 2018 Oct 15.

Department of Ophthalmology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Purpose: Enterococcus faecalis causes severe acute endophthalmitis and often leads to poor visual outcomes. Conjunctival bacterial cultures occasionally grow atypical bacteria including E. faecalis, which can potentially contribute to the development of postoperative endophthalmitis. Read More

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http://link.springer.com/10.1007/s10384-018-0630-5
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http://dx.doi.org/10.1007/s10384-018-0630-5DOI Listing
November 2018
16 Reads

Complicated bilateral fungal emphysematous pyelonephritis in a 55-year-old diabetic female: A case report and review of literature.

Curr Med Mycol 2018 Jun;4(2):32-35

Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medial Sciences, Tehran, Iran.

Background And Purpose: Emphysematous pyelonephritis (EPN) is a rare and serious disease causing acute renal failure. Diabetes is a major risk factor for this infection.

Case Report: Herein, we present the case of a 55-year-old female patient with diabetes and EPN caused by . Read More

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http://dx.doi.org/10.18502/cmm.4.2.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181061PMC
June 2018
12 Reads

Chronic postcataract endophthalmitis caused by species in an immunocompetent patient.

Int Med Case Rep J 2018 8;11:259-262. Epub 2018 Oct 8.

Department of Ophthalmology, National Defense Medical College, Tokorozawa, Japan,

Objective: species are abundant, generally saprophytic, and widely distributed in the environment. On rare occasions, they cause endophthalmitis in immunocompromised patients or in immunocompetent patients with uncontrolled diabetic mellitus or immunosuppressive agents. We report a case of endophthalmitis caused by species in an immunocompetent patient without any disorders. Read More

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https://www.dovepress.com/chronic-postcataract-endophthalmit
Publisher Site
http://dx.doi.org/10.2147/IMCRJ.S175374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181112PMC
October 2018
12 Reads

Utility of broad-range 16S rRNA PCR assay versus conventional methods for laboratory diagnosis of bacterial endophthalmitis in a tertiary care hospital.

Br J Ophthalmol 2019 Jan 12;103(1):152-156. Epub 2018 Oct 12.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Endophthalmitis, a sight-threatening intraocular infection, can be of postsurgical, post-traumatic or endogenous origin. Laboratory diagnosis-based appropriate therapy can be vision-saving. Conventional culture-based laboratory diagnosis takes time and lacks sensitivity. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3128
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http://dx.doi.org/10.1136/bjophthalmol-2018-312877DOI Listing
January 2019
2 Reads

Endogenous endophthalmitis: a 9-year retrospective study at a tertiary referral hospital in Malaysia.

J Ophthalmic Inflamm Infect 2018 Oct 11;8(1):14. Epub 2018 Oct 11.

Department of Opthalmology, Hospital Shah Alam, Shah Alam, Malaysia.

Background: The objective of this study was to determine the clinical presentation, systemic risk factors, source of infective microorganism, treatment outcomes, and prognostic indicators of endogenous endophthalmitis at a main tertiary referral hospital for uveitis in Malaysia. A retrospective review of medical records of 120 patients (143 eyes) with endogenous endophthalmitis over a period of 9 years between January 2007 and December 2015 was undertaken.

Results: Identifiable systemic risk factors were present in 79. Read More

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https://joii-journal.springeropen.com/articles/10.1186/s1234
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http://dx.doi.org/10.1186/s12348-018-0158-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179973PMC
October 2018
9 Reads

Filamentous gram-negative bacteria masquerading as actinomycetes in infectious endophthalmitis: a review of three cases.

J Ophthalmic Inflamm Infect 2018 Oct 11;8(1):15. Epub 2018 Oct 11.

Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L. V. Prasad Eye Institute, Hyderabad, India.

Background: To report microbiological diagnostic dilemma posed by observation of unusual morphology of bacteria in the vitreous sample of a series of three cases of bacterial endophthalmitis.

Results: A non-comparative, descriptive case series is described. All three cases presented to the retina-vitreous clinic with a clinical diagnosis of acute endophthalmitis between January and April 2018. Read More

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https://joii-journal.springeropen.com/articles/10.1186/s1234
Publisher Site
http://dx.doi.org/10.1186/s12348-018-0157-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179972PMC
October 2018
6 Reads

Elevated cytokine levels in vitreous as biomarkers of disease severity in infectious endophthalmitis.

PLoS One 2018 8;13(10):e0205292. Epub 2018 Oct 8.

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: To investigate the immunopathogenesis of endophthalmitis, and determine if cytokine profiles could serve as biomarkers of disease severity in infectious endophthalmitis.

Materials And Methods: Vitreous samples of 46 patients clinically diagnosed as endophthalmitis (of which 25 were culture positive) and 20 non-infectious controls from patients with Retinal Detachment (RD) or diabetic retinopathy were included in the study. The cytokine and chemokine expression patterns of 40 immune mediators including 6 antiinflammatory cytokines, 15 proinflammatory cytokines, 9 Growth factors and 10 proinflammatory chemokines in the vitreous were were analyzed by multiplex cytokine immunoassay. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205292PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175518PMC
October 2018
16 Reads
3.230 Impact Factor

Diagnosis, Clinical Presentations, and Outcomes of Nocardia Endophthalmitis.

Am J Ophthalmol 2019 Jan 19;197:53-58. Epub 2018 Sep 19.

Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India.

Purpose: To describe the clinical presentations, diagnosis, and management outcomes of Nocardia endophthalmitis.

Design: Retrospective, interventional, multicenter case series.

Methods: The study was conducted in a multicentric institutional practice setup and included 25 eyes of 25 patients with culture-proven Nocardia endophthalmitis. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.09.007DOI Listing
January 2019
44 Reads
3.870 Impact Factor

: A novel cause of fungal keratitis.

IDCases 2018 14;14:e00440. Epub 2018 Aug 14.

Havener Eye Institute, Department of Ophthalmology, The Ohio State University Wexner Medical Center, 915 Olentangy River Road, Columbus, Ohio 43212, USA.

A 45-year-old female with history of contact lens wear presented with a persistent corneal ulcer that was unresponsive to topical moxifloxacin. The patient's exam was concerning for fungal keratitis. Cultures were obtained, and the patient was started on fortified amphotericin B drops and oral voriconazole. Read More

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http://dx.doi.org/10.1016/j.idcr.2018.e00440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140800PMC
August 2018
17 Reads

Endogenous bacterial endophthalmitis and subretinal abscess complicating diabetic ketoacidosis.

BMJ Case Rep 2018 Sep 18;2018. Epub 2018 Sep 18.

Ophthalmology Department, King's College Hospital NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1136/bcr-2018-227025DOI Listing
September 2018
4 Reads

Unusual microbiological presentations in polymicrobial post-operative endophthalmitis and their clinical correlations.

Int Ophthalmol 2018 Sep 17. Epub 2018 Sep 17.

Jhaveri Microbiology Centre, L V Prasad Eye Institute, KAR Campus, Hyderabad, Telangana, India.

Purpose: To report the clinical course, microbiological spectrum and visual outcomes of three cases of post-operative endophthalmitis caused by unusual combination of micro-organisms.

Methods: Retrospective review of medical charts at a tertiary eye care centre over a period of 1 year, of subjects with post-operative endophthalmitis and more than one microbiological isolate.

Results: We report 3 cases with unusual combination of microorganisms. Read More

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http://dx.doi.org/10.1007/s10792-018-1019-7DOI Listing
September 2018
1 Read

Fungal endophthalmitis in a case of granulomatosis with polyangitis.

Saudi J Ophthalmol 2018 Jul-Sep;32(3):261-265. Epub 2018 Feb 2.

Department of Surgery-Division of Ophthalmology, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

A 70-year-old immuno-compromised man, due to multiple comorbidities, particularly granulomatosis with polyangitis (GPA) and its related treatment, presented with generalized weakness, odynophagia and loss of taste sensation. After a complete evaluation, a diagnosis of right frontal lobe brain abscess was made. The patient then developed headache and sudden painful loss of vision in the right eye. Read More

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http://dx.doi.org/10.1016/j.sjopt.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137701PMC
February 2018
2 Reads

Isavuconazole for Treatment of Experimental Fungal Endophthalmitis Caused by Aspergillus fumigatus.

Antimicrob Agents Chemother 2018 Nov 24;62(11). Epub 2018 Oct 24.

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, Detroit, Michigan, USA

Fungal endophthalmitis remains a significant cause of vision impairment and blindness. Moreover, the prognosis is poor, in part due to delay in diagnosis and to limited availability of effective antifungal agents with good ocular penetration. Thus, it is imperative to evaluate the therapeutic efficacy in fungal endophthalmitis of newer antifungal agents. Read More

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http://dx.doi.org/10.1128/AAC.01537-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201095PMC
November 2018
4.480 Impact Factor

Mucormycosis Endophthalmitis in a Silicone Oil-Filled Eye of an Immunocompetent Patient.

Ocul Immunol Inflamm 2018 Sep 7:1-3. Epub 2018 Sep 7.

a Advanced Eye Centre , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Purpose: Fungal endophthalmitis following pars plana vitrectomy with silicone oil tamponade is an infrequent entity. Filamentous fungi like aspergillus are generally associated with endophthalmitis. Mucor is a rarely implicated pathogen in cases of endophthalmitis with only two reported cases in medical literature. Read More

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http://dx.doi.org/10.1080/09273948.2018.1518462DOI Listing
September 2018

Successful treatment of endogenous endophthalmitis with extensive subretinal abscess: a case report.

BMC Ophthalmol 2018 Sep 5;18(1):238. Epub 2018 Sep 5.

Departments of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.

Background: Endogenous endophthalmitis could lead to a devastating outcome without a prompt and appropriate management. We report a case of advanced endogenous Klebsiella pneumoniae endophthalmitis with extensive subretinal abscess that was successfully treated with a vitrectomy.

Case Presentation: A systemically well 61-year-old man complained of ocular pain and visual decrease in his right eye for eighteen days. Read More

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http://dx.doi.org/10.1186/s12886-018-0908-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125994PMC
September 2018
12 Reads

Disseminated Nocardiosis with subretinal abscess in a patient with nephrotic syndrome-a case report.

BMC Ophthalmol 2018 Sep 3;18(1):234. Epub 2018 Sep 3.

Departments of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.

Background: Nocardia infection is uncommon in clinical practice, with most cases occuring as the result of opportunistic infection in immunocompromsed patients. Here, we report a case of disseminated nocardiosis with subretinal abscess in a patient with nephrotic syndrome, and whom is receiving immunosuppressive therapy.

Case Presentation: A 58-year-old male presented with decreased vision in his left eye, without redness or floaters, which had persisted for three days. Read More

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http://dx.doi.org/10.1186/s12886-018-0883-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122714PMC
September 2018
2 Reads

Hypervirulent K1 liver abscess and endogenous endophthalmitis in a Caucasian man.

Clin Case Rep 2018 Aug 3;6(8):1618-1623. Epub 2018 Jul 3.

Department of Bacteria, Parasites and Fungi Statens Serum Institut Copenhagen Denmark.

Invasive Liver Abscess Syndrome is the most frequent of a number of infectious syndromes caused by hypervirulent clones. While incidences peak in Southeast Asia, travels to Asia and Asian ethnicity are independent risk factors for infection in the western countries, although non-Asians are infected as well. Although challenging, a prompt diagnosis is of utmost importance to ensure adequate treatment and improve overall survival and visual outcome in cases with ocular involvement. Read More

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http://doi.wiley.com/10.1002/ccr3.1696
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http://dx.doi.org/10.1002/ccr3.1696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099053PMC
August 2018
9 Reads

Identification and Visualization of a Distinct Microbiome in Ocular Surface Conjunctival Tissue.

Invest Ophthalmol Vis Sci 2018 Aug;59(10):4268-4276

School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia.

Purpose: Knowledge of whether microorganisms reside in protected niches of the conjunctiva is potentially significant in terms of minimizing risks of contact lens inflammation/infection and endophthalmitis. We define if and how microbial communities from limbal and forniceal conjunctival tissue differ from those on the conjunctival surface.

Methods: Human limbal and forniceal conjunctival tissue was obtained from 23 patients undergoing pterygium surgery and analyzed with data from a recent study of conjunctival surface swabs (n = 45). Read More

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http://dx.doi.org/10.1167/iovs.18-24651DOI Listing
August 2018
13 Reads

Corneal abscess due to .

JMM Case Rep 2018 Jun 20;5(6):e005150. Epub 2018 Apr 20.

Department of Microbiology and Instituto Biosanitario, University Hospital Virgen de las Nieves, Granada, Spain.

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http://dx.doi.org/10.1099/jmmcr.0.005150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096928PMC

Sub-retinal abscess as presenting feature of endogenous Candida endophthalmitis.

BMC Res Notes 2018 Aug 17;11(1):598. Epub 2018 Aug 17.

Section of Ophthalmology, Aga Khan University Hospital, Stadium Road Karachi, Karachi, Pakistan.

Background: Sub-retinal abscess as the presenting feature in the setting of endogenous fungal endophthalmitis is extremely infrequent. Immunodeficiency states are major predisposing risk factors. To the best of our knowledge, this is the first case report of Candida sub-retinal abscess as initial presentation in an immunocompetent patient. Read More

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http://dx.doi.org/10.1186/s13104-018-3682-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098582PMC

Corynebacterium macginleyi-associated Blebitis: A Case Report.

J Glaucoma 2018 Oct;27(10):e174-e176

Departments of Ophthalmology.

Purpose: The purpose of this study was to report a rare case of posttrabeculectomy bleb-related infection associated with Corynebaterium macginleyi, a rare conjunctival pathogen.

Methods: Case description including clinical imaging and microbiology data, and literature review of Corynebacterium macginleyi-related infections.

Results: A 60-year-old glaucomatous female patient presented with a bleb-related infection 6 years after trabeculectomy in her right eye, suggestive of blebitis. Read More

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http://Insights.ovid.com/crossref?an=00061198-900000000-9836
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http://dx.doi.org/10.1097/IJG.0000000000001051DOI Listing
October 2018
4 Reads

Outcomes of combined keratoplasty and pars plana vitrectomy for endophthalmitis with compromised corneal clarity.

Clin Exp Ophthalmol 2019 Jan 23;47(1):49-56. Epub 2018 Aug 23.

Dr. Shroff's Charity Eye Hospital, New Delhi, India.

Importance: Studies evaluating combined penetrating keratoplasty and pars plana vitrectomy for infectious aetiologies are limited.

Background: To evaluate the outcomes of combined penetrating keratoplasty and pars plana vitrectomy in patients with endophthalmitis and poor corneal clarity.

Design: Retrospective interventional case series conducted at a tertiary care eye hospital in North India. Read More

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http://dx.doi.org/10.1111/ceo.13370DOI Listing
January 2019
3 Reads

Epidemiology of uveitis (2013-2015) and changes in the patterns of uveitis (2004-2015) in the central Tokyo area: a retrospective study.

BMC Ophthalmol 2018 Aug 2;18(1):189. Epub 2018 Aug 2.

Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: The distribution of uveitis varies with genetic, ethnic, geographic, environmental, and lifestyle factors. Epidemiological information about the patterns of uveitis is useful when an ophthalmologist considers the diagnosis of uveitis. Therefore, it is important to identify the causes of uveitis over the years in different regions. Read More

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http://dx.doi.org/10.1186/s12886-018-0871-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090933PMC
August 2018
2 Reads

Community-acquired group B streptococcal meningitis in adults: 33 cases from prospective cohort studies.

J Infect 2019 Jan 29;78(1):54-57. Epub 2018 Jul 29.

Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience, Meibergdreef 9, The Netherlands. Electronic address:

Objectives: Streptococcus agalactiae (group B streptococcus, GBS) is an uncommon cause of bacterial meningitis in adults. We describe clinical characteristics, serotype distribution and outcome of adult GBS meningitis.

Patients And Methods: Patients aged 16 years or older with GBS cultured in cerebrospinal fluid included in two prospective nationwide cohort studies performed in the Netherlands between 1998-2002 and 2006-2017 were evaluated. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.07.009DOI Listing
January 2019
4 Reads

Ocular culture-proven endogenous endophthalmitis: a 5-year retrospective study of the microorganism spectrum at a tertiary referral center in Turkey.

Int Ophthalmol 2018 Jul 26. Epub 2018 Jul 26.

Department of Ophthalmology, Marmara University School of Medicine, Fevzi Çakmak Mah. Muhsin Yazıcıoğlu Cad. No:10, Pendik/Istanbul, Turkey.

Purpose: The aim of this study was to review the clinical profile of endogenous endophthalmitis (EE), including predisposing systemic conditions, responsible microorganisms, clinical presentations, and outcomes.

Methods: We reviewed data from 21 eyes of 15 patients diagnosed with EE and compared their clinical characteristics over a 5-year period. All patients were ocular fluid cultures proven. Read More

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http://dx.doi.org/10.1007/s10792-018-0997-9DOI Listing
July 2018
1 Read

Bacterial endogenous endophthalmitis after colonoscopy.

Rev Esp Enferm Dig 2018 Sep;110(9):601

Aparato Digestivo, Hospital San Agustín, España.

We report a case with bacterial endogenous endophthalmitis caused by Streptococcus bovis, developed after colonoscopy, which had a poor outcome and resulted in evisceration. Bacterial endogenous endophthalmitis is a rare, but serious ocular disease that occurs when bacteria from a primary focus reach the eye. It requires a very early diagnosis. Read More

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http://dx.doi.org/10.17235/reed.2018.5658/2018DOI Listing
September 2018

CHALLENGES IN THE MANAGEMENT OF PRESUMED FUNGAL ENDOPHTHALMITIS IN PREGNANCY.

Retin Cases Brief Rep 2018 Jul 24. Epub 2018 Jul 24.

Johns Hopkins University, Wilmer Eye Institute, Baltimore, Maryland.

Purpose: To report a rare case of endogenous endophthalmitis in pregnancy and the challenges of managing culture-negative fungal infection.

Methods: Retrospective case report. A 30-year-old woman presented with a subfoveal chorioretinal lesion with vitritis and anterior chamber inflammation in the context of intravenous drug use. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000811DOI Listing
July 2018
1 Read