4,532 results match your criteria Endophthalmitis Fungal


Primary vitrectomy or intravitreal antibiotics followed by early vitrectomy for acute endophthalmitis: A prospective observational study.

Acta Ophthalmol 2022 Jun 25. Epub 2022 Jun 25.

Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.

Background/aims: To compare outcomes of acute endophthalmitis (EO) managed with either primary vitrectomy (PV) or primary intravitreal antibiotics (vancomycin and ceftazidime) followed by early vitrectomy (PIAEV) combined with polymerase chain reaction (PCR)-based diagnostics.

Methods: This was a prospective, comparative observational study of acute EO cases admitted to a regional vitreoretinal service over 18 months. Depending on whether immediate vitrectomy (within 6 h) was achievable, the EO cases were treated with either (1) PV or (2) PIAEV. Read More

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Ophthalmic infections caused by : A case series and short review of literature.

Curr Med Mycol 2021 Dec;7(4):43-48

Microbiology Department, All India Institute of Medical Sciences, New Delhi, India.

Background And Purpose: Although and are more commonly implicated with ocular infections; there are some saprophytic species, such as () which may occasionally lead to serious ocular infections. There is a paucity of data on ocular infections caused by . We report a case series of three ophthalmic infections caused by from a tertiary care eye center in North India. Read More

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December 2021

Endogenous Fungal Endophthalmitis: Causative Organisms, Treatments, and Visual Outcomes.

J Fungi (Basel) 2022 Jun 16;8(6). Epub 2022 Jun 16.

Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.

Endogenous fungal endophthalmitis (EFE) is a vision-threatening intraocular infection and a rare complication of fungemia. Early diagnosis and prompt aggressive treatment are crucial to avoid vision loss. We retrospectively reviewed the data of 37 patients (49 eyes) with EFE who were treated at a tertiary referral hospital from January 2000 to April 2019. Read More

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Complexities in diagnosing and treating endophthalmitis in the post stem cell transplant setting.

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Clinical Microbiology, HSE, Dublin, Ireland.

Endophthalmitis is a rare but sight-threatening manifestation of systemic infection. Immunosuppression is a well-recognised risk factor for development of endophthalmitis. Determining the aetiology can be complex, particularly in the context of immunosuppression, we present the diagnostic and treatment dilemmas associated with a patient who complains of blurred vision 2 weeks following an allogeneic stem cell transplant for refractory Hodgkin's disease. Read More

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Application of metagenomic next-generation sequencing in suspected intraocular infections.

Eur J Ophthalmol 2022 Jun 17:11206721221107311. Epub 2022 Jun 17.

Department of Ophthalmology, 74639Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Purpose: To evaluate the efficacy of metagenomic next-generation sequencing (mNGS) and to explore its value in the diagnosis of intraocular infection.

Methods: A retrospective case-series study of patients with suspected intraocular infection was performed. Intraocular fluid samples were collected from all the patients and sent for mNGS. Read More

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Ten-Year Analysis of Pathogenic Factors and Etiological Characteristics of Endophthalmitis from a Tertiary Eye Center in North China.

Infect Drug Resist 2022 10;15:3005-3012. Epub 2022 Jun 10.

Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China.

Purpose: To describe the etiology and spectrum of isolated pathogens in endophthalmitis over 10 years from an ophthalmic hospital in North China and report their antimicrobial susceptibilities.

Patients And Methods: The data covered the patients with endophthalmitis treated at Qingdao Eye Hospital from January 2011 to December 2020. Patients' medical history, pathogenic factors, bacterial and fungal culture results of intraocular specimens, and in vitro drug sensitivity test results were assessed. Read More

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Endophthalmitis Associated with a Retained Cilium in the Clear Corneal Wound after Cataract Surgery.

Case Rep Ophthalmol 2022 Jan-Apr;13(1):318-322. Epub 2022 Apr 28.

The Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA.

We report a case of endophthalmitis occurring secondary to a retained cilium in a clear corneal wound after cataract surgery. A 67-year-old female presented to an ophthalmology emergency room with light perception vision in the right eye 5 days after routine cataract surgery. Examination of the right eye demonstrated decreased vision, conjunctival injection, a corneal endoplaque, and anterior chamber fibrin. Read More

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Cluster outbreak of acute endophthalmitis following phacoemulsification: A report of 14 cases from North India.

Indian J Ophthalmol 2022 Jun;70(6):2084-2089

Department of Ophthalmology, Advanced Eye Centre, Chandigarh, India.

Purpose: To report clinical features, antibiotic susceptibility profile, management, and outcomes of a cluster outbreak of post-cataract surgery Pseudomonas stutzeri endophthalmitis.

Methods: This was a hospital-based case series in which 14 patients with acute postoperative endophthalmitis who underwent cataract surgery on the same day were included. Based on severity of presentation, they either underwent pars plana vitrectomy (PPV) with intraocular antibiotics (IOAB) or vitreous tap with IOAB. Read More

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Clinical characterization and whole genome sequence-based typing of two cases of endophthalmitis due to Listeria monocytogenes.

J Prev Med Hyg 2022 Mar 26;63(1):E139-E141. Epub 2022 Apr 26.

Department of Health Sciences, University of Milan, Milan, Italy.

Endophthalmitis due to Listeria monocytogenes is a rare form of listeriosis. Here, we report two cases that occurred in patients with different medical history, a 46-years-old woman with no comorbidities and an elderly man with several comorbidities. There was no history of trauma or surgery in either patient suggesting an endogenous origin. Read More

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Scedosporium aurantiacum: First isolation in Argentina from a previously healthy patient after traumatic inoculation.

Rev Argent Microbiol 2022 May 25. Epub 2022 May 25.

Servicio de Microbiología, Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan" Ciudad Autónoma de Buenos Aires, Argentina.

Scedosporium/Lomentospora species are widely distributed in nature. They are generally saprophytes, but can cause opportunistic infections in immunocompromised patients and occasionally in immunocompetent patients that are difficult to treat due to high levels of antifungal resistance. The distribution of Scedosporium/Lomentospora species shows regional differences. Read More

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First case of endophthalmitis by Corynespora cassiicola.

J Mycol Med 2022 May 22;32(4):101298. Epub 2022 May 22.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address:

Corynespora cassiicola is an environmental phytopathogen implicated in various human infections and has been isolated from one case of keratitis. We report here the first case of endophthalmitis caused by Corynespora cassiicola in a 54-year-old diabetic patient, who developed diminished vision, redness, and watering in the right eye, six weeks after intravitreal triamcinolone acetonide for non-proliferative diabetic retinopathy and macular oedema. Direct microscopy of the vitreous tap revealed septate hyphae, and culture grew white mycelium that turned olive-grey to black within two days and was confirmed as C. Read More

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Risk Factors and Clinical Characteristics of Patients with Ocular Candidiasis.

J Fungi (Basel) 2022 May 11;8(5). Epub 2022 May 11.

Department of Infection Control and Prevention, School of Medicine, Kurume University, Kurume 830-0011, Japan.

Ocular candidiasis is a critical and challenging complication of candidemia. The purpose of this study was to investigate the appropriate timing for ophthalmologic examinations, risk factors for complications of ocular lesions, and their association with mortality. This retrospective cohort study applied, using multiple logistic regression analysis and Cox regression models, to cases of candidemia (age ≥ 18 years) for patients who underwent ophthalmologic consultation. Read More

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Proteomic profiling of exosomes in a mouse model of Candida albicans endophthalmitis.

Exp Cell Res 2022 Aug 24;417(2):113222. Epub 2022 May 24.

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India; Ramoji Foundation Center of Ocular Infection, LV Prasad Eye Institute, Hyderabad, India. Electronic address:

Exosomes play pivotal roles in intercellular communication, and pathophysiological functions. In this study, we aimed to understand the role of exosomal proteome derived from C. albicans infected mice (C57BL/6) eyeball. Read More

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Characterization and proteome profiling of extracellular vesicles in a murine model of Staphylococcus aureus endophthalmitis.

Microbes Infect 2022 May 21:105014. Epub 2022 May 21.

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India. Electronic address:

Endophthalmitis is a vision-threatening complication of intraocular surgery or penetrating injury of which Staphylococcus aureus is an important etiological agent. Extracellular vesicles (EVs) holds a tremendous possibility for developing diagnostic and therapeutic biomarkers due to their role in the pathogenesis of various infections. The aim of this study was to characterise the protein cargo of EVs, isolated from a murine (C57BL/6) model of S. Read More

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The microbiological spectrum, antimicrobial resistance pattern, and visual outcomes of endogenous endophthalmitis in West Virginia 2009-2019.

Int Ophthalmol 2022 May 23. Epub 2022 May 23.

1 Medical Center Drive, West Virginia University Eye Institute, Morgantown, WV, 26506, USA.

Purpose: To report the microbiological spectrum, antimicrobial resistance patterns, and visual outcomes in patients with endogenous endophthalmitis (EE).

Methods: This was a retrospective study of 50 patients with culture-positive EE managed in a tertiary referral center between October 2009 and 2019. Clinical, microbiology analysis, and antimicrobial resistance were reviewed. Read More

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Enterobacter cloacae Keratitis: Clinicomicrobiological Profiles, Risk Factors, and Outcomes.

Cornea 2022 May 13. Epub 2022 May 13.

Cornea and Anterior Segment Service, The Cornea Institute, LV Prasad Eye Institute, GMR Varalakshmi Campus, Visakhapatnam, India; and.

Purpose: The purpose of the study was to report the clinical features, risk factors, antibiotic susceptibility, and treatment outcomes in a series of Enterobacter cloacae keratitis.

Methods: A retrospective analysis was performed of the electronic medical records of microbial keratitis caused by E. cloacae identified by the Vitek 2 system (BioMerieux, Craponne, France). Read More

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endogenous endophthalmitis post COVID-19 infection.

BMJ Case Rep 2022 May 11;15(5). Epub 2022 May 11.

Smt Kanuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, Hyderabad, Telangana, India

A man in mid-50s presented with progressive blurred vision in his left eye for over 6 weeks. He was a known diabetic with history of COVID-19 pneumonia treated with steroids and remdesivir. He had pyelonephritis and urinary culture grown He was referred as a case of non-resolving vitreous haemorrhage. Read More

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Posterior scleral perforation due to endogenous endophthalmitis in a pregnant with selective IgA deficiency.

Rom J Ophthalmol 2022 Jan-Mar;66(1):97-100

Department of Oculoplastic and Orbital Surgery, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

We present the case of a 35-year-old female patient, pregnant in her third trimester, with no ophthalmologic history of interest and a medical history of IgA deficiency syndrome with bronchiectasis as the only symptomatology, who came to another center with clinical symptoms of ocular discomfort. She was initially diagnosed with anterior uveitis and treated with topical and periocular corticosteroids. Edema and palpebral erythema appeared a few days later and she was diagnosed with idiopathic orbital inflammation and was treated with intravenous (I. Read More

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Fulminant fungal endogenous endophthalmitis following SARS-CoV-2 infection: A case report.

Indian J Ophthalmol 2022 05;70(5):1819-1821

Ocular Microbiology Service, L.V. Prasad Eye Institute, Mithu Tulsi Chanrai Campus, Bhubaneswar, Odisha, India.

Systemic corticosteroids and immunocompromised state following SARS-CoV-2 infection can predispose individuals to endogenous endophthalmitis. A 66-year-old gentleman presented with complaints of diminution of vision and redness one week post discharge after hospitalization for COVID-19 infection. Clinical examination suggested fulminant endogenous endophthalmitis which responded poorly even after aggressive treatment requiring evisceration. Read More

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Commentary: Is it time to re-evaluate the empiric intravitreal antibiotic therapy in infectious bacterial endophthalmitis?

Authors:
Taraprasad Das

Indian J Ophthalmol 2022 05;70(5):1701-1702

Vice Chair (Emeritus), LV Prasad Eye Institute, Hyderabad, Telangana, India.

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Real-life comparison of three intravitreal antibiotic drug regimens in endophthalmitis.

Indian J Ophthalmol 2022 05;70(5):1696-1700

Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Real-life comparison of three intravitreal drug regimens used in cases of endophthalmitis at a tertiary care center in India.

Methods: In this prospective, comparative study, patients of bacterial endophthalmitis were grouped according to intravitreal antibiotic drug regimens into Group 1 (ceftazidime and vancomycin), Group 2 (piperacillin + tazobactam and vancomycin), and Group 3 (imipenem and vancomycin). Forty-eight hours after injection nonresponding/worsening patients underwent vitrectomy. Read More

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Endogenous Fungal Endophthalmitis in a Patient Admitted to Intensive Care and Treated with Systemic Steroid for COVID-19

Turk J Ophthalmol 2022 04;52(2):139-141

Dokuz Eylül University Faculty of Medicine, Department of Ophthalmology, İzmir, Turkey

A 61-year-old woman presented to our clinic with complaints of decreased visual acuity, pain, and redness in her left eye. Best corrected visual acuity (BCVA) was 20/20 in the right eye and counting fingers at 3 meters in the left eye. On slit-lamp examination, 1+ cells were detected in the anterior chamber. Read More

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Investigation of Staphylococcus lugdunensis and Selected Coagulase Negative Staphylococci Isolated from Blood Culture bottles and Determination of their Sensitivities to Antibiotics.

Pak J Med Sci 2022 Mar-Apr;38(3Part-I):657-662

Yasar Nakipoglu, Istanbul Faculty of Medicine, Department of Medical Microbiology, Istanbul University, Istanbul, Turkey.

Objectives: Coagulase-negative staphylococci (CNS) are commensal skin microbiota but may also cause septicemia, endocarditis, and systemic infections. , is a member of CNS, but their antibiotic susceptibility test should be evaluated as not as CNS. We aimed to investigate and selected CNS strains by simple biochemical method and determination of their susceptibilities to antibiotics. Read More

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endogenous endophthalmitis in an immunocompetent man: treatment outcomes and swept-source optical coherence tomography findings.

BMJ Case Rep 2022 Apr 19;15(4). Epub 2022 Apr 19.

Microbiology, GHR Micro Diagnostics, Hyderabad, India.

A non-diabetic man in his 40s presented with a 4-day history of sudden, painless, rapidly progressive severe vision loss in his right eye. Anterior segment was unremarkable. A dense, solitary vitreous abscess with feathery margins obscured the macula. Read More

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Acute Post-Cataract Endophthalmitis Due to : A Rare Case Report.

Infect Drug Resist 2022 8;15:1651-1657. Epub 2022 Apr 8.

Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

species are a class of opportunistic pathogenic fungi widely present in the environment that cause invasive diseases in hosts with normal or weak immune functions. Common infections include peritonitis, endocarditis, osteomyelitis, and skin infections of wounds after burns, whereas endophthalmitis is rarely reported. Here, we report acute post-cataract endophthalmitis caused by in China. Read More

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Evaluation of Vitreous Galactomannan and (1, 3) β-D-Glucan Levels in the Diagnosis of Fungal Endophthalmitis in Southern India.

Ocul Immunol Inflamm 2022 Apr 11:1-7. Epub 2022 Apr 11.

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.

Purpose: To evaluate vitreous Galactomannan(GM) and 1,3 β-D-Glucan (BDG) levels in the diagnosis of fungal endophthalmitis, with emphasis on culture-negative cases.

Methods: Vitreous from 31 clinically suspected fungal endophthalmitis patients and 11 controls were evaluated for GM and BDG using ELISA Kits. The Receiver Operating Characteristic (ROC) curves and diagnostic significance was calculated. Read More

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Post-traumatic Fungal Keratitis and Endophthalmitis Caused by with Late Recurrence following Therapeutic Full-thickness Penetrating Keratoplasty.

Ocul Immunol Inflamm 2022 Apr 11:1-4. Epub 2022 Apr 11.

Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.

Background: To report a rare case of fungal keratitis and endophthalmitis due to .

Methods: Case report.

Results: A 71-year-old immunocompetent male sustained a corneal laceration, traumatic cataract, and retinal detachment due to penetrating injury from a nail pulled from a wooden deck. Read More

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Essential Role of NLRP3 Inflammasome in Mediating IL-1β Production and the Pathobiology of Staphylococcus aureus Endophthalmitis.

Infect Immun 2022 May 11;90(5):e0010322. Epub 2022 Apr 11.

Department of Ophthalmology, Visual and Anatomical Sciences/Kresge Eye Institute, Wayne State Universitygrid.254444.7 School of Medicine, Detroit, Michigan, USA.

Staphylococcal endophthalmitis is one of the leading causes of blindness following ocular surgery and trauma. Dysregulated inflammation during bacterial endophthalmitis causes host-induced inflammatory damage and vision loss if it remains unchecked. Emerging evidence indicates that inflammasome plays a critical role in regulating innate immunity in various infectious and inflammatory diseases. Read More

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Endogenous endophthalmitis caused by Streptococcus suis infection: a case report.

Authors:
Zhe Li Min Xu Xin Hua

BMC Ophthalmol 2022 Apr 9;22(1):165. Epub 2022 Apr 9.

Department of Ophthalmology, Subei Peoples' Hospital Affiliated to Yangzhou University, Yangzhou, China.

Background: Streptococcus suis (S. suis) is an emerging zoonotic human pathogen, which commonly causes meningitis and sepsis. Ocular infections associated with S. Read More

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C-DU(KE) Calculator: A Clinical Tool for Risk Stratification in Infectious Keratitis.

Cornea 2022 Mar 31. Epub 2022 Mar 31.

Department of Ophthalmology, Foster Center for Ocular Immunology, Duke Eye Center, Duke University School of Medicine, Durham, NC.

Purpose: The aim of this study was to identify characteristics of infectious keratitis predictive of poor outcome to develop a web-based predictive calculator.

Method: A retrospective chart review was performed at the Duke Eye Center. Two hundred fifteen adult patients with culture-proven infectious keratitis presenting between January 1, 2016, and December 31, 2020, were separated into a derivation set (136 patients, 53 positives; 83 controls) and a temporal validation set (79 patients, 26 positives; 53 controls). Read More

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