4,141 results match your criteria Endophthalmitis Fungal


Clinical Etiologies, Microbial Spectrum, Antibiotic Susceptibilities, and Visual Acuity Outcomes of Acute Endophthalmitis.

J Ocul Pharmacol Ther 2020 Jun 29. Epub 2020 Jun 29.

Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut, USA.

The purpose of this study was to report the clinical etiologies, microbial spectrum, antibiotic resistance, and visual acuity (VA) outcomes associated with acute endophthalmitis. A retrospective chart review of patients with International Classification of Diseases (ICD)-9 and ICD-10 codes for endophthalmitis over a 6-year period (2011-2016) at a tertiary referral center was performed. The clinical records were reviewed to evaluate clinical etiologies, microbial spectrum, antibiotic susceptibilities and resistance, and visual outcomes. Read More

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http://dx.doi.org/10.1089/jop.2018.0074DOI Listing

Twenty years of endophthalmitis: Incidence, aetiology and clinical outcome.

Acta Ophthalmol 2020 Jun 22. Epub 2020 Jun 22.

Department of Ophthalmology, Stavanger University Hospital, Stavanger, Norway.

Purpose: To review the incidence, aetiology and outcomes of endophthalmitis during a 20-year period in a Norwegian university hospital.

Methods: Single-centre retrospective review. Medical records of all patients admitted to Stavanger University Hospital with suspected endophthalmitis between January 1999 and December 2018 were reviewed. Read More

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http://dx.doi.org/10.1111/aos.14511DOI Listing

Fungal endocarditis in transplant recipients: a systematic review.

Mycoses 2020 Jun 18. Epub 2020 Jun 18.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Greece.

Background: Invasive fungal infections remain a major cause of morbidity and mortality in transplant recipients. Moreover, Fungal Infective Endocarditis (FIE) is a rare infection that carries a higher mortality than bacterial IE in normal host, while in transplant recipients may be even higher. The purpose of this study was to systemically review all published cases of FIE in solid organ and allogeneic bone marrow transplant recipients, describe the epidemiology, microbiology, clinical characteristics, treatment and outcomes of these infections, and to identify risk factors for mortality by FIE. Read More

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http://dx.doi.org/10.1111/myc.13132DOI Listing

Pre-operative conjunctival flora in patients with local and/or systemic risk factors for post cataract surgery infection in Northern Italy.

Eur J Ophthalmol 2020 Jun 19:1120672120934991. Epub 2020 Jun 19.

University Eye Clinic, IRCCS, Policlinico San Matteo, Pavia, Italy.

Purpose: To investigate the pre-operative conjunctival flora in patients undergoing cataract surgery with major local and/or systemic risk factors for developing post-operative infection.

Methods: A total of 83 patients underwent bacterial culture and sensitivity testing of conjunctival swabs obtained from both eyes because of local risk factors at the pre-operative visit (i.e. Read More

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http://dx.doi.org/10.1177/1120672120934991DOI Listing

A Novel Vitreous Culture Technique.

Retin Cases Brief Rep 2020 Jun 5. Epub 2020 Jun 5.

Colorado Retina Associates, PC, 8101 E Lowry Blvd, Suite 210, Denver, CO 80230.

Purpose: This is the first case series of a novel method of collecting and transporting a vitreous specimen after a vitreous tap and injection for infectious endophthalmitis.

Methods: Case series RESULTS:: Four consecutive cases of presumed infectious endophthalmitis underwent an in-office vitreous tap and antibiotic injection. The vitreous specimen was injected into the ESwab liquid-based collection and transport system for microbiology samples. Read More

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http://dx.doi.org/10.1097/ICB.0000000000001012DOI Listing

CLINICAL UTILITY OF BETA-D-GLUCAN TESTING FOR ENDOGENOUS FUNGAL CHORIORETINITIS OR ENDOPHTHALMITIS.

Retina 2020 Jun 8. Epub 2020 Jun 8.

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania.

Purpose: To evaluate serum beta-D-glucan (BDG) as a biomarker for endogenous fungal eye infection.

Methods: Retrospective case-control study of 88 patients with a BDG test and eye examination at UPenn (2013-2018). Cases had endogenous fungal chorioretinitis or endophthalmitis diagnosed by eye examination and confirmed with positive culture; controls were without these fungal eye findings. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002861DOI Listing

Clinical Review of Microbial Corneal Ulcers Resulting in Enucleation and Evisceration in a Tertiary Eye Care Center in Hungary.

J Ophthalmol 2020 18;2020:8283131. Epub 2020 May 18.

Department of Ophthalmology, Semmelweis University, Budapest, Hungary.

Purpose: To analyse the clinical and microbiological characteristics and preexisting ophthalmic and systemic conditions of infectious keratitis resulting in enucleation/evisceration in a large tertiary referral center in a developed country (Hungary) over a period of 12 years. . A retrospective review of enucleated/eviscerated eyes undergoing surgery between 2007 and 2018 at the Department of Ophthalmology of Semmelweis University, Budapest, Hungary, with infectious keratitis as the primary indication for enucleation or evisceration. Read More

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http://dx.doi.org/10.1155/2020/8283131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254073PMC

Bacterial contamination of intravitreal needles by the ocular surface microbiome.

Ocul Surf 2020 Jun 1. Epub 2020 Jun 1.

School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia.

Purpose: The ocular surface microbiota are recognised as one of causative microorganisms in post-procedural endophthalmitis but in many cases the vitreous tap is culture negative. This study investigated bacterial contamination of intravitreal (IVT) needles using multiple approaches covering culturing, 16S rRNA gene sequencing, fluorescent in situ hybridisation (FISH) and scanning electron microscopy (SEM).

Methods: IVT needles were obtained immediately after injection from patients undergoing treatment for predominantly age-related macular degeneration. Read More

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http://dx.doi.org/10.1016/j.jtos.2020.05.010DOI Listing

The first case of fungal endogenous endophthalmitis caused by : Diagnostic and therapeutic challenge.

Eur J Ophthalmol 2020 Jun 3:1120672120932088. Epub 2020 Jun 3.

Hospital General Universitario de Valencia, Valencia, Spain.

Significance: Fungal endogenous endophthalmitis is an uncommon and potentially blinding infection. is a causative organism in immunocompromized although is virulent enough to afflict immunocompetents. Their propensity to affect macula usually results in a dismal prognosis; thus, improving visual outcome has always been challenging to clinicians. Read More

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http://dx.doi.org/10.1177/1120672120932088DOI Listing

Effect of intravitreal ceftazidime injection on endogenous klebsiella pneumoniae endophthalmitis, a single center case series.

Medicine (Baltimore) 2020 May;99(22):e20521

Department of Ophthalmology Sanggye Paik Hospital, Inje University of Korea, College of Medicine, Seoul, Republic of Korea.

To report long-term outcomes of intravitreal ceftazidime injection in patients with endogenous Klebsiella pneumoniae endophthalmitis (EKPE).This was a retrospective observational case study, including 7 eyes from 6 patients with EKPE. The medical records from January 2010 to December 2018 were reviewed. Read More

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http://dx.doi.org/10.1097/MD.0000000000020521DOI Listing

Endophthalmitis in Advanced Microbial Keratitis: Risk Factors and Examination Findings.

Cornea 2020 May 29. Epub 2020 May 29.

Department of Ophthalmology, University of Michigan Medical School, Ann Arbor, MI.

Purpose: To evaluate clinical and ultrasonographic findings associated with advanced microbial keratitis with concurrent endophthalmitis.

Methods: We performed a retrospective analytical study of patients with severe microbial keratitis who underwent ocular ultrasonography for possible endophthalmitis at our institution over a 5-year period. Ocular and medical history, ocular examination findings, microbiology results, and ultrasonographic features were collected. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002349DOI Listing

Saprochaete capitata aortitis in an immunocomopetent patient after myocardial revascularization.

Cardiovasc Pathol 2020 Sep - Oct;48:107223. Epub 2020 Apr 28.

Cardiothoracic Department, University Hospital of Udine, Udine, Italy.

Saprochaete species infection is a rare fungal disease reported so far only in immunocompromised patients. We describe the first case of aortitis caused by Saprochaete capitata, presenting as ascending aorta aneurysm, with secondary endophthalmitis in an immunocompetent patient. Infection by Saprochaete capitata is potentially fatal, with a mortality ranging from 50% to 90% of cases. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107223DOI Listing

Glycolytic inhibitor 2-deoxyglucose suppresses inflammatory response in innate immune cells and experimental staphylococcal endophthalmitis.

Exp Eye Res 2020 May 23;197:108079. Epub 2020 May 23.

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, Detroit, MI, USA; Department of Biochemistry, Microbiology, and Immunology, Wayne State University, Detroit, MI, USA; Graduate School, Wayne State University, Detroit, MI, USA. Electronic address:

Previously, we have shown that Staphylococcus (S) aureus induces a glycolytic response in retinal residential (microglia) and infiltrated cells (neutrophils and macrophages) during endophthalmitis. In this study, we sought to investigate the physiological role of glycolysis in bacterial endophthalmitis using a glycolytic inhibitor, 2-deoxyglucose (2DG). Our data showed that 2DG treatment attenuated the inflammatory responses of mouse bone marrow-derived macrophages (BMDM) and neutrophils (BMDN) when challenged with either live or heat-killed S. Read More

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http://dx.doi.org/10.1016/j.exer.2020.108079DOI Listing
May 2020
2.709 Impact Factor

Arthrographis kalrae Keratitis Complicated by Endophthalmitis: A Case Report With Literature Review.

Eye Contact Lens 2020 May 14. Epub 2020 May 14.

Division of Clinical Neuroscience (D.S.J.T.), Academic Ophthalmology, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Ophthalmology (D.S.J.T.), Queen's Medical Centre, Nottingham, United Kingdom; Departments of Ophthalmology (D.S.J.T., M.M., S.N.S., T.P.), and Microbiology (J.M.), James Cook University Hospital, Middlesbrough, United Kingdom; and National Specialist Ophthalmic Pathology Service (H.S.M.), Royal Hallamshire Hospital, Sheffield, United Kingdom.

Objectives: To report the first case of Arthrographis kalrae keratitis complicated by endophthalmitis in the UK and to review the current literature.

Methods: A case report with literature review.

Results: A 65-year-old male patient, with a background of treated B-cell lymphoma and herpes simplex virus-related neurotrophic keratopathy, presented with a large infiltrative corneal ulcer in the right eye. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000713DOI Listing

Combination of Lidocaine Gel and Povidone-Iodine to Decrease Acquired Infections in Procedures Performed Using Topical Anesthesia.

J Cataract Refract Surg 2020 May 15. Epub 2020 May 15.

From Emory University School of Medicine (Xia, Lyons, Lin), Department of Ophthalmology, Emory University School of Medicine (Khalifa), Department of Ophthalmology, Grady Memorial Hospital (Khalifa), Department of Microbiology and Immunology (LaRock), Emory University School of Medicine, Division of Infectious Disease (LaRock), Emory University School of Medicine, Emory Antibiotic Resistance Center (LaRock), Atlanta, Georgia, USA.

Purpose: To test the antiseptic efficacy of povidone-iodine when mixed with topical lidocaine gel .

Setting: Emory School of Medicine, Atlanta, Georgia, USA.

Design: Experimental study. Read More

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http://dx.doi.org/10.1097/j.jcrs.0000000000000245DOI Listing

Multidrug-Resistant Evokes Differential Inflammatory Responses in Human Microglial and Retinal Pigment Epithelial Cells.

Microorganisms 2020 May 14;8(5). Epub 2020 May 14.

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana 500034, India.

Increasing incidences of multidrug-resistant (MDR) pathogens causing endophthalmitis threaten our ability to treat this condition, and the modulation of inflammatory responses by MDR bacteria is not known. In this study, using human microglia and retinal pigment epithelial (RPE) cells, we compare the inflammatory responses of sensitive (S-) and multidrug-resistant (MDR-) clinical isolates of . Infected cells were subjected to qPCR analysis, enzyme-linked immunosorbent assay (ELISA), and immunostaining to assess the expression of inflammatory mediators. Read More

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http://dx.doi.org/10.3390/microorganisms8050735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285153PMC

Microbiological Isolates and Antibiotic Susceptibilities in Cases of Posttraumatic Endophthalmitis: A 15-Year Review.

J Ophthalmol 2020 29;2020:5053923. Epub 2020 Apr 29.

Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Purpose: The objective of this study was to evaluate the microbiological spectrum and antibiotic susceptibilities of isolates in posttraumatic endophthalmitis over a 15-year period.

Methods: A retrospective study of 3,163 posttraumatic endophthalmitis cases was conducted between July 2004 and July 2019. The outcome measures included the microbiological spectrum and antibiotic susceptibilities. Read More

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http://dx.doi.org/10.1155/2020/5053923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210529PMC

Listeria monocytogenes, a rare cause of endophthalmitis.

Rev Esp Quimioter 2020 Jun 13;33(3):216-217. Epub 2020 May 13.

Isabel Casanovas Moreno-Torres, Department of Microbiology. Hospital Virgen de las Nieves. Granada. Avda. de las Fuerzas Armadas 2, 18014. Spain.

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http://dx.doi.org/10.37201/req/097.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262384PMC

Recurrent fungal endophthalmitis after intravitreal injections of bevacizumab.

Am J Ophthalmol Case Rep 2020 Mar 7;17:100591. Epub 2020 Jan 7.

Department of Ophthalmology, Saarland University Medical Center UKS, 66421, Homburg/Saar, Germany.

Purpose: We intend to describe an uncommon case of recurrent post-cataract fungal endophthalmitis after intravitreal injections of Bevacizumab.

Observations: A 73-year-old male, who underwent an uncomplicated cataract surgery 8 months ago, presented to our department with postoperative endophthalmitis 5 days after his fifth intravitreal injection (IVI) of bevacizumab for treatment of cystoid macula edema caused by central retinal venous occlusion 6 months ago. The visual acuity (VA) was 0. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206407PMC

Asymmetric retinopathy of prematurity in presumed fungal endophthalmitis.

Am J Ophthalmol Case Rep 2020 Jun 23;18:100722. Epub 2020 Apr 23.

Bascom Palmer Eye Institute, Miami, FL, USA.

Purpose: To report a case of asymmetric retinopathy of prematurity (ROP) in a neonate with endophthalmitis.

Observations: A 25-week old female was born by caesarean section due to preeclampsia. The patient required supplemental oxygen after birth. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200213PMC

Fungal Endophthalmitis.

N Engl J Med 2020 May;382(19):e48

University of Arkansas for Medical Sciences, Little Rock, AR

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http://dx.doi.org/10.1056/NEJMicm1911882DOI Listing

Posterior hypopyon in fungal endogenous endophthalmitis secondary to presumably contaminated dextrose infusion.

Am J Ophthalmol Case Rep 2020 Jun 1;18:100681. Epub 2020 Apr 1.

Advanced Eye Centre, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: To describe the presentation, clinical course and management of a patient with posterior hypopyon secondary to atypical (fungal) endogenous endophthalmitis.

Observations: A 55-year-old Asian Indian female presented with decreased vision in the left eye (OS). The best-corrected visual acuity was 20/20 in the right eye (OD) and counting fingers (CF) in the left eye (OS) at the time of initial presentation. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191180PMC

Fungal Keratitis, or Misled by a Small Insect?

Turk J Ophthalmol 2020 Apr;50(2):107-109

Koç University Faculty of Medicine, Department of Ophtalmology, İstanbul, Turkey.

The pine processionary caterpillar is an insect that has multiple small, thin hairs around its body as a defense mechanism. These hairs have a hazardous effect on ocular structures and cause a broad range of reactions from conjunctivitis to endophthalmitis, referred to as ophthalmia nodosa. The diagnosis of the disease is based on the patient's history and the detection of the hairs on ocular structures. Read More

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http://dx.doi.org/10.4274/tjo.galenos.2019.30670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204900PMC

Lenticular fungal infection caused by Aspergillus in a patient with traumatic corneal laceration: a case report.

BMC Ophthalmol 2020 May 1;20(1):173. Epub 2020 May 1.

Department of Cornea and Refractive Surgery, Kim's Eye Hospital, Myunggok Eye Research Institute, Konyang University College of Medicine, 136, Yeongshin-ro, Yeongdeungpo-gu, Seoul, South Korea.

Background: To report a case of lenticular infection caused by Aspergillus, which was diagnosed 13 weeks after traumatic corneal laceration.

Case Presentation: A 60-year-old woman presented with traumatic corneal laceration including anterior lens capsule rupture and traumatic cataract after being hit with a chestnut in the right eye. There were multiple injuries due to tiny thorns of the chestnut, including the conjunctiva, sclera, cornea, and anterior lens capsule. Read More

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http://dx.doi.org/10.1186/s12886-020-01441-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195745PMC

Gram-negative endophthalmitis: A prospective study examining the microbiology, clinical associations and visual outcomes following infection.

Clin Exp Ophthalmol 2020 Apr 29. Epub 2020 Apr 29.

Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.

Importance: This is the largest Gram-negative endophthalmitis specific series and provides important evidence to guide management.

Background: Endophthalmitis is a sight-threatening emergency. Gram-negative infections are associated with poorer visual outcomes; however, there is limited literature pertaining to this uncommon condition. Read More

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http://dx.doi.org/10.1111/ceo.13768DOI Listing

Aspergillus endophthalmitis: Potential role for vitreous galactomannan testing?

Int J Infect Dis 2020 Apr 24;96:151-153. Epub 2020 Apr 24.

Hospices Civils de Lyon, Institut de Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Lyon, France, Université Claude Bernard Lyon I, Lyon, France.

Eye damage during invasive aspergillosis is rarely described and biological diagnosis remains challenging. Here we report the case of a heart transplant recipient with ocular aspergillosis complicating disseminated aspergillosis. Although voriconazole was rapidly given, a decrease in visual acuity of the right eye was consistent with endophthalmitis, resulting in an emergency vitrectomy. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.04.037DOI Listing

Expression of Virulence-Related Genes in an Ocular Infection-Related Environment.

Microorganisms 2020 Apr 22;8(4). Epub 2020 Apr 22.

Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

produces many factors linked to pathogenesis and is recognized for causing gastrointestinal toxemia and infections. also causes a fulminant and often blinding intraocular infection called endophthalmitis. We reported that the PlcR/PapR system regulates intraocular virulence, but the specific factors that contribute to virulence in the eye remain elusive. Read More

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http://dx.doi.org/10.3390/microorganisms8040607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232466PMC

The role of the Coagulase-negative staphylococci (CoNS) in infective endocarditis; a narrative review from 2000 to 2020.

Curr Pharm Biotechnol 2020 Apr 23. Epub 2020 Apr 23.

Department of Microbiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud. Iran.

Coagulase-negative staphylococci (CoNS) are part of the microbiota of human skin and rarely linked with soft tissue infections. In recent years, CoNS species considered as one of the major nosocomial pathogens and can cause several infections such as catheter-acquired sepsis, skin infection, urinary tract infection, endophthalmitis, central nervous system shunt infection, surgical site infections, and foreign body infection. These microorganisms have a significant impact on human life and health and, as typical opportunists, cause peritonitis in individuals undergoing peritoneal dialysis. Read More

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http://dx.doi.org/10.2174/1389201021666200423110359DOI Listing
April 2020
2.511 Impact Factor

Clinical presentations, microbiology and management outcomes of culture-proven endogenous endophthalmitis in India.

Indian J Ophthalmol 2020 May;68(5):834-839

Vitreoretina and Uveitis Service, GMR Varalakshmi Campus, LV Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India.

Purpose: To report the clinical presentation, microbiology, and management outcome of endogenous endophthalmitis in Indian patients.

Methods: Retrospective chart review of culture-positive (vitreous/urine/blood) endogenous endophthalmitis cases treated in tertiary eye care facility in India was done.

Results: The study included 173 eyes of 117 patients. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1091_19DOI Listing
May 2020
0.927 Impact Factor

Clinical profile and outcome of endogenous endophthalmitis at a quaternary referral centre in south India.

Indian J Ophthalmol 2020 May;68(5):827-833

Department of Biostatistics, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.

Purpose: The purpose of this study is to evaluate the clinical profile, visual, anatomical and survival outcome of patients with endogenous endophthalmitis.

Methods: Retrospective chart review of consecutive cases with endogenous endophthalmitis presenting from 2009-2016.

Results: In our study, 41 eyes of 34 patients were included. Read More

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http://dx.doi.org/10.4103/ijo.IJO_948_19DOI Listing

Endophthalmitis prophylaxis study. Report 1: Intracameral cefuroxime and moxifloxacin prophylaxis for the prevention of postcataract endophthalmitis in rural India.

Indian J Ophthalmol 2020 May;68(5):819-824

Allen Foster Research Centre for Community Eye Health, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care, L V Prasad Eye Institute (LVPEI), Banjara Hills, Hyderabad, India.

Purpose: Intracameral antibiotics are known to reduce the incidence of acute endophthalmitis. Various drugs are available for intracameral use. This prospective study was carried out to compare the efficacies of intracameral cefuroxime and moxifloxacin prophylaxis in reducing the incidence of acute endophthalmitis after cataract surgery in rural India. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1400_19DOI Listing
May 2020
0.927 Impact Factor

A CARE-compliant article: a case report of pleural empyema secondary to Klebsiella pneumoniae liver abscess with a hepatopleural fistula.

Medicine (Baltimore) 2020 Apr;99(16):e19869

Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, Jung-gu, Incheon, South Korea.

Introduction: Klebsiella pneumoniae liver abscess (KPLA) is often associated with accompanying metastatic complications such as septic pulmonary embolism, brain abscess, and endophthalmitis. Pleural empyema secondary to a KPLA is a very unusual finding, made even more rare with the presence of a hepatopleural fistula.

Patient Concerns: An 81-year-old woman presented with aggravated dyspnea. Read More

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http://dx.doi.org/10.1097/MD.0000000000019869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220185PMC

Molecular identification of species causing endophthalmitis using multilocus sequence analysis (MLSA): a 10-year perspective.

J Med Microbiol 2020 May 20;69(5):728-738. Epub 2020 Apr 20.

Department of Ocular Microbiology, Aravind Eye Hospital, Madurai, India.

spp. can cause several ocular infections, such as keratitis, endophthalmitis and scleral abscesses. Molecular identification of spp. Read More

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http://dx.doi.org/10.1099/jmm.0.001180DOI Listing
May 2020
2.248 Impact Factor

[A clinical analysis of 1 414 cases of fungal keratitis].

Zhonghua Yan Ke Za Zhi 2020 Apr;56(4):286-293

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, China.

To discuss clinical features and treatments of fungal keratitis, and to provide statistical data for clinical therapy and increase the therapeutic effects. This is a retrospective case series study. An analysis was performed by collecting patients' demography features, risk factors, onset time, lab results, clinical features and treatment from 1 414 cases of fungal keratitis from January 2006 to October 2016 in Qingdao Eye Hospital, Shandong Eye Institute. Read More

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http://dx.doi.org/10.3760/cma.j.cn112142-20190618-00320DOI Listing

Post-cataract Surgery Fungal Endophthalmitis: Management Outcomes and Prognostic Factors.

Ocul Immunol Inflamm 2020 Apr 10:1-7. Epub 2020 Apr 10.

Department of Vitreo-Retina, Aravind Eye Hospital, Madurai, India.

: To describe the clinical and microbiological features, management outcomes, and prognostic factors of visual improvement in post-cataract surgery fungal endophthalmitis.: We evaluated 17 patients with culture-confirmed fungal endophthalmitis following cataract surgery. Data were collected regarding intravitreal antibiotics and antifungals, pars plana vitrectomy (PPV), intraocular lens (IOL) explantation, and scleral-fixated IOL (SFIOL) implantation. Read More

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http://dx.doi.org/10.1080/09273948.2020.1737143DOI Listing
April 2020
1.440 Impact Factor

Mechanisms of Pathogenic Species to Evade the Host Complement Attack.

Front Cell Infect Microbiol 2020 12;10:94. Epub 2020 Mar 12.

Department of Microbiology, University of Szeged, Szeged, Hungary.

species are common colonizers of the human skin, vagina, and the gut. As human commensals, species do not cause any notable damage in healthy individuals; however, in certain conditions they can initiate a wide range of diseases such as chronic disseminated candidiasis, endocarditis, vaginitis, meningitis, and endophthalmitis. The incidence of caused infections has increased worldwide, with mortality rates exceeding 70% in certain patient populations. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082757PMC

Endophthalmitis Postcataract Operation.

Case Rep Ophthalmol Med 2020 12;2020:1513069. Epub 2020 Mar 12.

Department of Microbiology, Tokyo Medical University, Japan.

Purpose: To present our findings in a case of delayed-onset postoperative endophthalmitis caused by , a rare organism. . A 57-year-old man presented with epiphora and photophobia 17 weeks after a routine cataract extraction with phacoemulsification and intraocular lens implantation. Read More

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http://dx.doi.org/10.1155/2020/1513069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091523PMC

Ophthalmology Consultation to Detect Endogenous Endophthalmitis: Clinical Characteristics in Consulted Versus Diagnosed Cases Among At-Risk Inpatients.

Ophthalmic Surg Lasers Imaging Retina 2020 03;51(3):159-A3

Background And Objective: Predisposing factors for ophthalmology consultations and endogenous endophthalmitis were compared among inpatients with systemic infection.

Patients And Methods: This was a retrospective cohort study in a tertiary care hospital between January 1, 2010, and December 31, 2014. Multivariable logistic regression was utilized. Read More

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http://dx.doi.org/10.3928/23258160-20200228-05DOI Listing

Bleb-related tuberculous endophthalmitis following combined phacoemulsification and trabeculectomy with mitomycin C.

BMJ Case Rep 2020 Mar 24;13(3). Epub 2020 Mar 24.

Glaucoma, LV Prasad Eye Institute, Hyderabad, Telangana, India

A one-eyed 67-year-old man with 20/400 vision, dense cataract, previously failed trabeculectomy and medically uncontrolled advanced glaucoma underwent a single-site phacoemulsification with repeat trabeculectomy and mitomycin C. One-week postoperatively, vision in the right eye improved to 20/120, good bleb and intraocular pressure (IOP) of 14 mm Hg. By third postoperative week, patient presented to the emergency with diminished vision, pain and redness in right eye of 2 days duration and was diagnosed to have bleb-related endophthalmitis (BRE). Read More

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http://dx.doi.org/10.1136/bcr-2019-234175DOI Listing

Utility of Intraocular Fluid β-D-glucan Testing in Fungal Endophthalmitis: A Series of 5 Cases.

Am J Case Rep 2020 Mar 23;21:e921188. Epub 2020 Mar 23.

Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China (mainland).

BACKGROUND In clinical practice, the presentation of fungal endophthalmitis is often occult and confusing, so it is difficult to make an early diagnosis. The aim of this study was to evaluate the utility of ß-d-glucan (BDG) testing in diagnosis, management, and prognosis of fungal endophthalmitis. CASE REPORT We present a retrospective, observational case series of 5 fungal endophthalmitis cases, 3 of which were endogenous and 2 exogenous. Read More

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http://dx.doi.org/10.12659/AJCR.921188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124016PMC

Unusual case of endophthalmitis: Case report and literature review.

Oman J Ophthalmol 2020 Jan-Apr;13(1):37-39. Epub 2020 Feb 17.

Department of Ophthalmology, Sultan Qaboos University Hospital, Seeb, Muscat, Sultanate of Oman.

Endophthalmitis is an inflammation of both the anterior and posterior chamber. It is diagnosed clinically and involvement of retina and choroid has been documented. (1) Endophthalmitis is classified into infectious and no-infectious categories. Read More

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http://dx.doi.org/10.4103/ojo.OJO_48_2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050449PMC
February 2020

Antibiotic sensitivity trends of pseudomonas endophthalmitis in a tertiary eye care center in South India: A 12-year retrospective study.

Indian J Ophthalmol 2020 04;68(4):627-631

Vitreoretina Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Pondicherry, India.

Purpose: To assess trends in antibiotic sensitivity of pseudomonas and compare multidrug resistance (MDR) between Pseudomonas endophthalmitis cases presenting in two consecutive 6-year time frames in a tertiary center in South India.

Methods: This is a retrospective comparative series of all Pseudomonas endophthalmitis cases treated from June 2004 to May 2016. Microbiological culture results in all endophthalmitis patients were screened for pseudomonas. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1145_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210830PMC
April 2020
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Clinical Presentations and Comparative Outcomes of Delayed-Onset Low-Grade Endophthalmitis Managed with or Without Intraocular Lens Explantation.

Clin Ophthalmol 2020 26;14:551-555. Epub 2020 Feb 26.

Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India.

Purpose: To compare the outcomes of delayed-onset low-grade endophthalmitis managed with and without intraocular lens (IOL) explantation.

Setting: Tertiary eye-care research institute in southern India.

Design: Retrospective comparative case series. Read More

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http://dx.doi.org/10.2147/OPTH.S243496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049778PMC
February 2020

New Pathological Lesions Developed in Pigs by a "Non-virulent" Strain of .

Front Vet Sci 2020 25;7:98. Epub 2020 Feb 25.

Laboratory of Microbiology and Advanced Immunology, Faculty of Agronomy and Veterinary Medicine, University of Passo Fundo, Passo Fundo, Brazil.

is a Gram-negative bacterium that causes Glässer's disease, a common pathology found in young pigs characterized by polyarthritis, polyserositis, and meningitis. The bacterium has 15 known serovars that have been classified by virulence. Serovars 1, 4, 5, and 12 are considered highly virulent and used in most studies. Read More

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http://dx.doi.org/10.3389/fvets.2020.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052124PMC
February 2020

S-Layer-Mediated Innate Interactions During Endophthalmitis.

Front Immunol 2020 12;11:215. Epub 2020 Feb 12.

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.

endophthalmitis is a severe intraocular infection. Hallmarks of endophthalmitis include robust inflammation and rapid loss of vision. We reported that the absence of surface layer protein (SLP) significantly blunted endophthalmitis severity. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028758PMC
February 2020

Molecular identification of species complex isolated from clinical samples and its antifungal susceptibility patterns.

Curr Med Mycol 2019 ;5(4):43-49

Department of Microbiology, Government Medical College Hospital, Chandigarh, India.

Background And Purpose: More than 300 species are grouped into approximately 23 species complexes out of which around 70 are involved in human infections. The nomenclature of these species has undergone considerable changes in recent years. These species cause localized infections in individuals while inducing systemic infections mainly in immunocompromised patients. Read More

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http://dx.doi.org/10.18502/cmm.5.4.2149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034782PMC
January 2019

Nine-Year Analysis of Isolated Pathogens and Antibiotic Susceptibilities of Infectious Endophthalmitis from a Large Referral Eye Center in Southern China.

Infect Drug Resist 2020 13;13:493-500. Epub 2020 Feb 13.

Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People's Republic of China.

Purpose: To analyze the pathogen spectrum of isolated pathogens and antibiotic susceptibility trends of infectious endophthalmitis over 9 years from a large referral eye center in southern China.

Methods: Data from all inpatients who were clinically diagnosed with infectious endophthalmitis and underwent microbiological evaluation at the Zhongshan Ophthalmic Center from January 2010 to December 2018 were collected retrospectively and analyzed according to different clinical etiologies.

Results: A total of 816 cases were collected in the study. Read More

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http://dx.doi.org/10.2147/IDR.S235954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025819PMC
February 2020

The cereus matter of Bacillus endophthalmitis.

Exp Eye Res 2020 Apr 4;193:107959. Epub 2020 Feb 4.

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Ophthalmology, Dean McGee Eye Institute, Oklahoma City, OK, USA; Oklahoma Center for Neuroscience, Oklahoma City, OK, USA; Dean A. McGee Eye Institute, Oklahoma City, OK, USA. Electronic address:

Bacillus cereus (B. cereus) endophthalmitis is a devastating intraocular infection primarily associated with post-traumatic injuries. The majority of these infections result in substantial vision loss, if not loss of the eye itself, within 12-48 h. Read More

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http://dx.doi.org/10.1016/j.exer.2020.107959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113113PMC

Retinal vascular inflammatory and occlusive changes in infectious and non-infectious uveitis.

Jpn J Ophthalmol 2020 Mar 3;64(2):150-159. Epub 2020 Feb 3.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.

Purpose: Retinal vasculitis and occlusive changes are important signs of posterior uveitis and are possible diagnostic markers for uveitis. However, the frequency of arteritis and phlebitis in various uveitis entities, including infectious uveitis (IU) and non-infectious uveitis (NIU), have not been systematically investigated.

Study Design: Retrospective. Read More

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http://dx.doi.org/10.1007/s10384-020-00717-4DOI Listing