4,274 results match your criteria Endophthalmitis Bacterial

Seasonal and environmental variations in endophthalmitis after intravitreal anti-vascular endothelial growth factor injection: a six-year review.

Curr Eye Res 2022 Jun 27:1-17. Epub 2022 Jun 27.

The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA.

Purpose/aim: To evaluate seasonal and environmental variations on the incidence and outcomes of post-injection endophthalmitis.

Materials And Methods: A single-center, retrospective cohort study was conducted including all patients diagnosed with post-injection endophthalmitis between 2013-2018. Associations between climate variables and endophthalmitis incidence were evaluated. Read More

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Application of metagenomic next-generation sequencing in suspected intraocular infections.

Eur J Ophthalmol 2022 Jun 17:11206721221107311. Epub 2022 Jun 17.

Department of Ophthalmology, 74639Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Purpose: To evaluate the efficacy of metagenomic next-generation sequencing (mNGS) and to explore its value in the diagnosis of intraocular infection.

Methods: A retrospective case-series study of patients with suspected intraocular infection was performed. Intraocular fluid samples were collected from all the patients and sent for mNGS. Read More

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Ten-Year Analysis of Pathogenic Factors and Etiological Characteristics of Endophthalmitis from a Tertiary Eye Center in North China.

Infect Drug Resist 2022 10;15:3005-3012. Epub 2022 Jun 10.

Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China.

Purpose: To describe the etiology and spectrum of isolated pathogens in endophthalmitis over 10 years from an ophthalmic hospital in North China and report their antimicrobial susceptibilities.

Patients And Methods: The data covered the patients with endophthalmitis treated at Qingdao Eye Hospital from January 2011 to December 2020. Patients' medical history, pathogenic factors, bacterial and fungal culture results of intraocular specimens, and in vitro drug sensitivity test results were assessed. Read More

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A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis.

Bioact Mater 2023 Feb 2;20:271-285. Epub 2022 Jun 2.

Eye Center, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR China.

Postoperative endophthalmitis (POE) has been the most threatening complication after cataract surgery, which perhaps can be solved by the antibiotic-loaded intraocular lens (IOL). However, most drug-loaded IOLs demonstrate insufficient drug quantity, short release time, increased implantation-related difficulties or other noticeable drawbacks. To prevent POE and to address these deficiencies, a drug-loaded copolymer IOL, prepared from poly (urethane acrylate) prepolymer, isobornyl methacrylate (IBOMA), N-vinyl-2-pyrrolidone (NVP), Irgacure 819, RUVA-93, and gatifloxacin (GAT), was rapidly fabricated via photocuring and by using a 3D-printed mold. Read More

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February 2023

Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure.

Cochrane Database Syst Rev 2022 06 6;6:CD012131. Epub 2022 Jun 6.

Stein Eye Institute, UCLA, Los Angeles, California, USA.

Background: Endophthalmitis refers to severe infection within the eye that involves the aqueous humor or vitreous humor, or both, and that threatens vision. Most cases of endophthalmitis are exogenous (i.e. Read More

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Cluster outbreak of acute endophthalmitis following phacoemulsification: A report of 14 cases from North India.

Indian J Ophthalmol 2022 Jun;70(6):2084-2089

Department of Ophthalmology, Advanced Eye Centre, Chandigarh, India.

Purpose: To report clinical features, antibiotic susceptibility profile, management, and outcomes of a cluster outbreak of post-cataract surgery Pseudomonas stutzeri endophthalmitis.

Methods: This was a hospital-based case series in which 14 patients with acute postoperative endophthalmitis who underwent cataract surgery on the same day were included. Based on severity of presentation, they either underwent pars plana vitrectomy (PPV) with intraocular antibiotics (IOAB) or vitreous tap with IOAB. Read More

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The microbiological spectrum, antimicrobial resistance pattern, and visual outcomes of endogenous endophthalmitis in West Virginia 2009-2019.

Int Ophthalmol 2022 May 23. Epub 2022 May 23.

1 Medical Center Drive, West Virginia University Eye Institute, Morgantown, WV, 26506, USA.

Purpose: To report the microbiological spectrum, antimicrobial resistance patterns, and visual outcomes in patients with endogenous endophthalmitis (EE).

Methods: This was a retrospective study of 50 patients with culture-positive EE managed in a tertiary referral center between October 2009 and 2019. Clinical, microbiology analysis, and antimicrobial resistance were reviewed. Read More

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Factors associated with postoperative visual outcome in acute endophthalmitis after cataract surgery-a cross-sectional, analytical study.

Digit J Ophthalmol 2022 12;28(1):1-6. Epub 2022 Feb 12.

Department of Cataract and IOL services, Aravind Eye Hospital, Madurai, India.

Purpose: To identify predictors of visual outcome in patients with acute endophthalmitis following cataract surgery.

Methods: This cross-sectional study included consecutive patients with acute endophthalmitis following cataract surgery at our tertiary care center between January 2017 and June 2018. Baseline demographic details, surgical details, and treatment offered were extracted from the medical record, and patients were followed for 3 months after diagnosis and treatment for endophthalmitis. Read More

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endogenous endophthalmitis post COVID-19 infection.

BMJ Case Rep 2022 May 11;15(5). Epub 2022 May 11.

Smt Kanuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, Hyderabad, Telangana, India

A man in mid-50s presented with progressive blurred vision in his left eye for over 6 weeks. He was a known diabetic with history of COVID-19 pneumonia treated with steroids and remdesivir. He had pyelonephritis and urinary culture grown He was referred as a case of non-resolving vitreous haemorrhage. Read More

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Posterior scleral perforation due to endogenous endophthalmitis in a pregnant with selective IgA deficiency.

Rom J Ophthalmol 2022 Jan-Mar;66(1):97-100

Department of Oculoplastic and Orbital Surgery, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

We present the case of a 35-year-old female patient, pregnant in her third trimester, with no ophthalmologic history of interest and a medical history of IgA deficiency syndrome with bronchiectasis as the only symptomatology, who came to another center with clinical symptoms of ocular discomfort. She was initially diagnosed with anterior uveitis and treated with topical and periocular corticosteroids. Edema and palpebral erythema appeared a few days later and she was diagnosed with idiopathic orbital inflammation and was treated with intravenous (I. Read More

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Commentary: Is it time to re-evaluate the empiric intravitreal antibiotic therapy in infectious bacterial endophthalmitis?

Taraprasad Das

Indian J Ophthalmol 2022 05;70(5):1701-1702

Vice Chair (Emeritus), LV Prasad Eye Institute, Hyderabad, Telangana, India.

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Real-life comparison of three intravitreal antibiotic drug regimens in endophthalmitis.

Indian J Ophthalmol 2022 05;70(5):1696-1700

Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Real-life comparison of three intravitreal drug regimens used in cases of endophthalmitis at a tertiary care center in India.

Methods: In this prospective, comparative study, patients of bacterial endophthalmitis were grouped according to intravitreal antibiotic drug regimens into Group 1 (ceftazidime and vancomycin), Group 2 (piperacillin + tazobactam and vancomycin), and Group 3 (imipenem and vancomycin). Forty-eight hours after injection nonresponding/worsening patients underwent vitrectomy. Read More

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Strabismus Surgery: A Retrospective Comparison of Different Postoperative Treatment Regimes to Prevent Infections.

Klin Monbl Augenheilkd 2022 Apr 26;239(4):593-596. Epub 2022 Apr 26.

University Eye Hospital Basel, Basel, Switzerland.

Background: As studies have shown postsurgical polyvidone-iodine to be at least equal to postsurgical topical antibiotics, our postsurgical care regime was adjusted accordingly in 2017. Here, we retrospectively compared the postsurgical infection rate in patients who underwent strabismus surgery prior to and following this change in regimen in a routine clinical setting.

Patients And Methods: In this retrospective and explorative study, data from 162 adult patients who had undergone strabismus surgery was extracted from files: 98 patients who had received topical gentamycin in a combination ointment with steroid (postsurgery) followed by 1 week of topical gentamycin with nonsteroidal antiphlogistic eye drops for 1 week (group 1) and 64 who had received polyvidone-iodine once immediately postsurgically instead. Read More

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Successful identification of in postoperative acute infectious endophthalmitis using a bacterial 16S ribosomal RNA gene-sequencing platform with MinION™: A case report.

Am J Ophthalmol Case Rep 2022 Jun 12;26:101524. Epub 2022 Apr 12.

Department of Ophthalmology, Kansai Medical University, Japan.

Purpose: To evaluate the efficacy of identifying the bacteria by aqueous sampling and vitreous sampling in postoperative infectious endophthalmitis using 16S ribosomal RNA (rRNA) gene analysis with a nanopore sequencer (MinION™).

Observation: A 55-year-old woman who underwent cataract surgery at an ophthalmology clinic 18 days ago was referred to our hospital for suspected endophthalmitis. She had light perception visual acuity in her right eye; however, the eye was severely inflamed, with a hypopyon and a fibrinous membrane in the anterior chamber. Read More

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Postoperative endophthalmitis associated with asymptomatic bacteriuria.

BMJ Case Rep 2022 Apr 22;15(4). Epub 2022 Apr 22.

Ophthalmology, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK.

An 86-year-old man with diabetes and a history of prostate cancer, indwelling urinary catheter and bacteriuria presented on day 4 post left phacoemulsification cataract extraction and intraocular lens implant with signs and symptoms of postoperative endophthalmitis. Vitreous sample was positive for Prompt treatment with intravitreal antibiotics was initiated followed by anterior chamber washout with pars plana vitrectomy; however, the visual outcome was poor. Read More

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Risk factors and microbiological characteristics: from bacterial keratitis with hypopyon to keratitis-related endophthalmitis.

Graefes Arch Clin Exp Ophthalmol 2022 Apr 20. Epub 2022 Apr 20.

Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, 372 Jingsi Road, Jinan, 250021, China.

Purpose: To compare the clinical and microbiological characteristics in patients with bacterial keratitis with hypopyon (BKH), bacterial keratitis-related endophthalmitis (BKE), and bacterial endophthalmitis without keratitis (BE).

Methods: Data from all inpatients who were clinically diagnosed with BKH, BKE, and BE from 2018 to 2020 were collected retrospectively. The demographics, predisposing risk factors, clinical characteristics, microbiological profiles, and antibiotic susceptibility of the patients were evaluated. Read More

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Endogenous Aeromonas caviae Endophthalmitis: A Case Report.

Korean J Ophthalmol 2022 04 4;36(2):174-175. Epub 2022 Apr 4.

Department of Ophthalmology, Dong-A University College of Medicine, Busan, Korea.

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Management of glaucoma with Boston type 1 keratoprosthesis.

Arq Bras Oftalmol 2022 Mar 7. Epub 2022 Mar 7.

Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.

Purpose: To describe the frequency, clinical characteristics, complications, and management of glaucoma in eyes that underwent keratoprosthesis implantation.

Methods: Patients who underwent keratoprosthesis surgery between June 2010 and January 2020 were retrospectively evaluated for glaucoma association and prognoses.

Results: Among 17 patients who underwent keratoprosthesis surgery, 9 (52. Read More

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Spinal canal infection caused by Streptococcus suis in human: a case report.

BMC Infect Dis 2022 Apr 12;22(1):369. Epub 2022 Apr 12.

Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.

Background: Streptococcus suis is an emerging zoonotic pathogen that mainly causes meningitis, sepsis, arthritis, endocarditis, and endophthalmitis in human. To the best of our knowledge, Spinal canal infection caused by Streptococcus suis has rarely been reported.

Case Presentation: Here we report a case of spinal canal infection caused by Streptococcus suis in a 50-year-old male patient. Read More

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An Atypical Case of Exogeneous Endophthalmitis after Intravitreal Injection Presenting with Roth Spots.

Ocul Immunol Inflamm 2022 Apr 12:1-7. Epub 2022 Apr 12.

Department of Ophthalmology, Ankara University School of Medicine, Ankara, Turkey.

Purpose: To report an atypical case of exogeneous endophthalmitis presenting with Roth spots.

Case: A 67-year-old man presented with decreased vision, mild pain, and discomfort in his left eye 12 days after an intravitreal aflibercept injection. Best-corrected visual acuity was 20/200, and there were +3 anterior chamber cells. Read More

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Essential Role of NLRP3 Inflammasome in Mediating IL-1β Production and the Pathobiology of Staphylococcus aureus Endophthalmitis.

Infect Immun 2022 May 11;90(5):e0010322. Epub 2022 Apr 11.

Department of Ophthalmology, Visual and Anatomical Sciences/Kresge Eye Institute, Wayne State Universitygrid.254444.7 School of Medicine, Detroit, Michigan, USA.

Staphylococcal endophthalmitis is one of the leading causes of blindness following ocular surgery and trauma. Dysregulated inflammation during bacterial endophthalmitis causes host-induced inflammatory damage and vision loss if it remains unchecked. Emerging evidence indicates that inflammasome plays a critical role in regulating innate immunity in various infectious and inflammatory diseases. Read More

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Endogenous endophthalmitis caused by Streptococcus suis infection: a case report.

Zhe Li Min Xu Xin Hua

BMC Ophthalmol 2022 Apr 9;22(1):165. Epub 2022 Apr 9.

Department of Ophthalmology, Subei Peoples' Hospital Affiliated to Yangzhou University, Yangzhou, China.

Background: Streptococcus suis (S. suis) is an emerging zoonotic human pathogen, which commonly causes meningitis and sepsis. Ocular infections associated with S. Read More

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Intracameral Bacteriophage Injection as Postoperative Prophylaxis for Enterococcus faecalis-Induced Endophthalmitis After Cataract Surgery in Rabbits.

Transl Vis Sci Technol 2022 04;11(4)

Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Kochi, Japan.

Purpose: Post-cataract surgery bacterial endophthalmitis is a serious postoperative complication, and Enterococcus spp.-induced endophthalmitis reportedly has a particularly poor visual prognosis. This study aimed to demonstrate the prophylactic effect of postoperative intracameral phage administration in Enterococcus faecalis-induced endophthalmitis after cataract surgery in rabbits. Read More

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Characterizing the microbiota of instrumentation in ophthalmology clinics during and beyond the COVID-19 pandemic.

Graefes Arch Clin Exp Ophthalmol 2022 Mar 31. Epub 2022 Mar 31.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD, 21287, USA.

Purpose: Increased ophthalmology-specific risk of novel coronavirus 2019 (SARS-CoV-2) transmission is well-established, increasing the fear of infection and causing associated decreased rates of procedures known to save vision. However, the potential transmission from exposure to clinic instrumentation is unknown, including which additional pathogens may be spreading in this context. This study seeks to fill this gap by characterizing the microbiota of instrumentation in ophthalmology clinics during the COVID-19 pandemic and identifying potential sources of pathogenic spread encountered by patients and healthcare workers. Read More

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invasion syndrome: a case of liver abscess combined with lung abscess, endophthalmitis, and brain abscess.

J Int Med Res 2022 Mar;50(3):3000605221084881

Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China.

invasion syndrome (KPIS) is a critical multi-site infection that is usually caused by highly virulent . It is relatively common in Asian patients with diabetes and leads to sepsis, which has a high mortality rate. We report the case of a man in his early 40s who presented to the hospital with blurred vision in his left eye of 7 days' duration and fever of 1 day's duration. Read More

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Antibiotic susceptibility of bacterial pathogens isolated from the aqueous and vitreous humour in the Antibiotic Resistance Monitoring in Ocular micRoorganisms (ARMOR) Surveillance Study: 2009-2020 update.

J Glob Antimicrob Resist 2022 Jun 23;29:236-240. Epub 2022 Mar 23.

Scripps Health, La Jolla, California.

Objectives: We evaluated antibiotic resistance among intraocular isolates obtained from presumed endophthalmitis cases collected from 2009 through 2020 in the Antibiotic Resistance Monitoring in Ocular micRoorganisms (ARMOR) study, the only ongoing nationwide surveillance study tracking in vitro resistance in ocular pathogens.

Methods: Presumed endophthalmitis isolates obtained from the aqueous humour and vitreous humour were collected from participating centres, and minimum inhibitory concentrations were determined and interpreted per Clinical and Laboratory Standards Institute methods and available breakpoints.

Results: A total of 307 presumed endophthalmitis isolates (aqueous humour, n = 88; vitreous humour, n = 219) were obtained from 43 clinical sites, including 188 coagulase-negative staphylococci (CoNS), 61 Staphylococcus aureus, 31 Streptococcus pneumoniae, 14 Pseudomonas aeruginosa, and 13 Haemophilus influenzae isolates. Read More

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Effect of polymicrobial interactions on antimicrobial resistance: an analysis in human ocular infections.

Future Microbiol 2022 05 22;17:491-504. Epub 2022 Mar 22.

Ocular Microbiology Services, LV Prasad Eye Institute, Mithu Tulsi Chanrai Campus, Bhubaneswar, 751024, India.

Investigate the effect of polymicrobial interactions on antimicrobial resistance (AMR) of ocular pathogens in polymicrobial settings, compared with monomicrobial infections. Polymicrobial interactions were labeled as antagonistic, synergistic or indifferent based on a reduction, an increase or no change, respectively, in antibiotics' MIC by the Vitek 2 compact system, compared with monomicrobial pathogens. showed antagonistic polymicrobial interactions (22. Read More

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