3,840 results match your criteria Endophthalmitis Bacterial


Management and Visual Outcomes of Acute Bacterial Endophthalmitis Following Intravitreal Injection of Contaminated Bevacizumab in a Single Day.

Ophthalmic Surg Lasers Imaging Retina 2020 Jun;51(6):346-352

Background And Objective: Bevacizumab requires compounding for off-label intravitreal injection, thus creating a risk of possible contamination during preparation.

Patients And Methods: This retrospective, consecutive case series from a single site included patients who developed culture-proven acute endophthalmitis after intravitreal injection with contaminated bevacizumab. All patients suspected of endophthalmitis had vitreous biopsy and microbial cultures prior to initiation of treatment and were managed with immediate tap and injection of antibiotics followed early by pars plana vitrectomy. Read More

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http://dx.doi.org/10.3928/23258160-20200603-05DOI Listing

Ciprofloxacin Loaded Nanostructured Lipid Carriers Incorporated into In-Situ Gels to Improve Management of Bacterial Endophthalmitis.

Pharmaceutics 2020 Jun 19;12(6). Epub 2020 Jun 19.

Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA.

Bacterial endophthalmitis (BE) is a potentially sight-threatening inflammatory reaction of the intraocular fluids or tissues caused by bacteria. Ciprofloxacin (CIP) eye drops are prescribed as first-line therapy in BE. However, frequent administration is necessary due to precorneal loss and poor ocular bioavailability. Read More

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http://dx.doi.org/10.3390/pharmaceutics12060572DOI Listing

Twenty years of endophthalmitis: Incidence, aetiology and clinical outcome.

Acta Ophthalmol 2020 Jun 22. Epub 2020 Jun 22.

Department of Ophthalmology, Stavanger University Hospital, Stavanger, Norway.

Purpose: To review the incidence, aetiology and outcomes of endophthalmitis during a 20-year period in a Norwegian university hospital.

Methods: Single-centre retrospective review. Medical records of all patients admitted to Stavanger University Hospital with suspected endophthalmitis between January 1999 and December 2018 were reviewed. Read More

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http://dx.doi.org/10.1111/aos.14511DOI Listing

Fungal endocarditis in transplant recipients: a systematic review.

Mycoses 2020 Jun 18. Epub 2020 Jun 18.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Greece.

Background: Invasive fungal infections remain a major cause of morbidity and mortality in transplant recipients. Moreover, Fungal Infective Endocarditis (FIE) is a rare infection that carries a higher mortality than bacterial IE in normal host, while in transplant recipients may be even higher. The purpose of this study was to systemically review all published cases of FIE in solid organ and allogeneic bone marrow transplant recipients, describe the epidemiology, microbiology, clinical characteristics, treatment and outcomes of these infections, and to identify risk factors for mortality by FIE. Read More

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http://dx.doi.org/10.1111/myc.13132DOI Listing

Pre-operative conjunctival flora in patients with local and/or systemic risk factors for post cataract surgery infection in Northern Italy.

Eur J Ophthalmol 2020 Jun 19:1120672120934991. Epub 2020 Jun 19.

University Eye Clinic, IRCCS, Policlinico San Matteo, Pavia, Italy.

Purpose: To investigate the pre-operative conjunctival flora in patients undergoing cataract surgery with major local and/or systemic risk factors for developing post-operative infection.

Methods: A total of 83 patients underwent bacterial culture and sensitivity testing of conjunctival swabs obtained from both eyes because of local risk factors at the pre-operative visit (i.e. Read More

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http://dx.doi.org/10.1177/1120672120934991DOI Listing

Intraoperative Cefuroxime Irrigation Prophylaxis for Acute-Onset Endophthalmitis After Phacoemulsification Surgery.

Infect Drug Resist 2020 18;13:1455-1463. Epub 2020 May 18.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Qingdao, People's Republic of China.

Purpose: Acute-onset postoperative endophthalmitis usually compromises the visual function and anatomical integrity of the eye. The aim of this study was to evaluate the efficacy of intraoperative cefuroxime use in irrigating solution on prevention of acute-onset endophthalmitis after phacoemulsification.

Methods: This retrospective, comparative, interventional cohort study included patients who underwent phacoemulsification between January 1, 2012, and December 31, 2019. Read More

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http://dx.doi.org/10.2147/IDR.S252674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244738PMC

Endophthalmitis after strabismus surgery: incidence and outcome in relation to age, operated eye muscle, surgical technique, scleral perforation and immune state.

Acta Ophthalmol 2020 Jun 13. Epub 2020 Jun 13.

University Eye Clinic, Freiburg, Germany.

Purpose: Identify risk factors for endophthalmitis after strabismus surgery (EASS) and relate these to incidence and outcome.

Methods: Ophthalmologists, who had operated, diagnosed or treated EASS, completed a case record form with 71 questions in six domains: Preoperative, Surgery, Perforation, Postoperative, Outcome and Experts' opinion. To estimate the age-specific incidence per number of strabismus operations in the Netherlands during 1994-2013, the age distribution of Dutch cases was compared with the age-specific rates of strabismus surgery in the Dutch Registry of Strabismus Operations and with population data. Read More

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http://dx.doi.org/10.1111/aos.14446DOI Listing

Infectious Endophthalmitis in the Current Era.

Ophthalmol Retina 2020 06;4(6):553-554

Aurora, Colorado.

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http://dx.doi.org/10.1016/j.oret.2020.04.002DOI Listing

Bacterial contamination of intravitreal needles by the ocular surface microbiome.

Ocul Surf 2020 Jun 1. Epub 2020 Jun 1.

School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia.

Purpose: The ocular surface microbiota are recognised as one of causative microorganisms in post-procedural endophthalmitis but in many cases the vitreous tap is culture negative. This study investigated bacterial contamination of intravitreal (IVT) needles using multiple approaches covering culturing, 16S rRNA gene sequencing, fluorescent in situ hybridisation (FISH) and scanning electron microscopy (SEM).

Methods: IVT needles were obtained immediately after injection from patients undergoing treatment for predominantly age-related macular degeneration. Read More

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http://dx.doi.org/10.1016/j.jtos.2020.05.010DOI Listing

Effect of intravitreal ceftazidime injection on endogenous klebsiella pneumoniae endophthalmitis, a single center case series.

Medicine (Baltimore) 2020 May;99(22):e20521

Department of Ophthalmology Sanggye Paik Hospital, Inje University of Korea, College of Medicine, Seoul, Republic of Korea.

To report long-term outcomes of intravitreal ceftazidime injection in patients with endogenous Klebsiella pneumoniae endophthalmitis (EKPE).This was a retrospective observational case study, including 7 eyes from 6 patients with EKPE. The medical records from January 2010 to December 2018 were reviewed. Read More

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http://dx.doi.org/10.1097/MD.0000000000020521DOI Listing

Is it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery?

BMC Ophthalmol 2020 May 27;20(1):208. Epub 2020 May 27.

Department of Ophthalmology, Tianjin Medical University General Hospital, No. 154 Anshan Road, Tianjin, 300052, China.

Background: There are no data available regarding the complications associated with using antibiotic ointment at the end of intraocular surgery. This study aimed to explore the necessity of using ocular tobramycin-dexamethasone prophylactically at the end of intraocular surgery.

Methods: This was a retrospective cohort study of patients who received intraocular surgery at Tianjin Medical University General Hospital from January 2015 to December 2017. Read More

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http://dx.doi.org/10.1186/s12886-020-01476-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254748PMC
May 2020
1.075 Impact Factor

Glycolytic inhibitor 2-deoxyglucose suppresses inflammatory response in innate immune cells and experimental staphylococcal endophthalmitis.

Exp Eye Res 2020 May 23;197:108079. Epub 2020 May 23.

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, Detroit, MI, USA; Department of Biochemistry, Microbiology, and Immunology, Wayne State University, Detroit, MI, USA; Graduate School, Wayne State University, Detroit, MI, USA. Electronic address:

Previously, we have shown that Staphylococcus (S) aureus induces a glycolytic response in retinal residential (microglia) and infiltrated cells (neutrophils and macrophages) during endophthalmitis. In this study, we sought to investigate the physiological role of glycolysis in bacterial endophthalmitis using a glycolytic inhibitor, 2-deoxyglucose (2DG). Our data showed that 2DG treatment attenuated the inflammatory responses of mouse bone marrow-derived macrophages (BMDM) and neutrophils (BMDN) when challenged with either live or heat-killed S. Read More

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http://dx.doi.org/10.1016/j.exer.2020.108079DOI Listing
May 2020
2.709 Impact Factor

Combination of Lidocaine Gel and Povidone-Iodine to Decrease Acquired Infections in Procedures Performed Using Topical Anesthesia.

J Cataract Refract Surg 2020 May 15. Epub 2020 May 15.

From Emory University School of Medicine (Xia, Lyons, Lin), Department of Ophthalmology, Emory University School of Medicine (Khalifa), Department of Ophthalmology, Grady Memorial Hospital (Khalifa), Department of Microbiology and Immunology (LaRock), Emory University School of Medicine, Division of Infectious Disease (LaRock), Emory University School of Medicine, Emory Antibiotic Resistance Center (LaRock), Atlanta, Georgia, USA.

Purpose: To test the antiseptic efficacy of povidone-iodine when mixed with topical lidocaine gel .

Setting: Emory School of Medicine, Atlanta, Georgia, USA.

Design: Experimental study. Read More

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http://dx.doi.org/10.1097/j.jcrs.0000000000000245DOI Listing

Efficacy of 0.5% Levofloxacin and 5.0% Povidone-Iodine Eyedrops in Reducing Conjunctival Bacterial Flora: Metagenomic Analysis.

J Ophthalmol 2020 17;2020:1780498. Epub 2020 Apr 17.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Qingdao 266071, China.

Bacteria associated with postoperative endophthalmitis mostly originate from the normal bacterial flora of the patient's conjunctiva and eyelids, so the incidence of endophthalmitis may be reduced by eliminating the ocular and adnexal flora before surgery. We assessed the effectiveness of eyedrops of 0.5% levofloxacin and 5. Read More

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http://dx.doi.org/10.1155/2020/1780498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183532PMC

Gram-negative endophthalmitis: A prospective study examining the microbiology, clinical associations and visual outcomes following infection.

Clin Exp Ophthalmol 2020 Apr 29. Epub 2020 Apr 29.

Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.

Importance: This is the largest Gram-negative endophthalmitis specific series and provides important evidence to guide management.

Background: Endophthalmitis is a sight-threatening emergency. Gram-negative infections are associated with poorer visual outcomes; however, there is limited literature pertaining to this uncommon condition. Read More

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http://dx.doi.org/10.1111/ceo.13768DOI Listing

Clinical profile and outcome of endogenous endophthalmitis at a quaternary referral centre in south India.

Indian J Ophthalmol 2020 May;68(5):827-833

Department of Biostatistics, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.

Purpose: The purpose of this study is to evaluate the clinical profile, visual, anatomical and survival outcome of patients with endogenous endophthalmitis.

Methods: Retrospective chart review of consecutive cases with endogenous endophthalmitis presenting from 2009-2016.

Results: In our study, 41 eyes of 34 patients were included. Read More

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http://dx.doi.org/10.4103/ijo.IJO_948_19DOI Listing

A CARE-compliant article: a case report of pleural empyema secondary to Klebsiella pneumoniae liver abscess with a hepatopleural fistula.

Medicine (Baltimore) 2020 Apr;99(16):e19869

Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, Jung-gu, Incheon, South Korea.

Introduction: Klebsiella pneumoniae liver abscess (KPLA) is often associated with accompanying metastatic complications such as septic pulmonary embolism, brain abscess, and endophthalmitis. Pleural empyema secondary to a KPLA is a very unusual finding, made even more rare with the presence of a hepatopleural fistula.

Patient Concerns: An 81-year-old woman presented with aggravated dyspnea. Read More

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http://dx.doi.org/10.1097/MD.0000000000019869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220185PMC

Molecular identification of species causing endophthalmitis using multilocus sequence analysis (MLSA): a 10-year perspective.

J Med Microbiol 2020 May 20;69(5):728-738. Epub 2020 Apr 20.

Department of Ocular Microbiology, Aravind Eye Hospital, Madurai, India.

spp. can cause several ocular infections, such as keratitis, endophthalmitis and scleral abscesses. Molecular identification of spp. Read More

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http://dx.doi.org/10.1099/jmm.0.001180DOI Listing
May 2020
2.248 Impact Factor

Traumatic endophthalmitis and the outcome after vitrectomy in young children.

Int J Ophthalmol 2020 18;13(3):406-411. Epub 2020 Mar 18.

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Aim: To explore the traumatic endophthalmitis in young children and the outcome of pars plana vitrectomy (PPV).

Methods: Twenty-two eyes of 22 cases of young children consecutive pediatric traumatic endophthalmitis treated and followed up between September 2014 and May 2018 were included. Aqueous humor or vitreous samples were taken for bacterial culture and sensitivity tests. Read More

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http://dx.doi.org/10.18240/ijo.2020.03.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154189PMC

Post-intravitreal injection endophthalmitis secondary to Turicella otitidis: a case report.

BMC Ophthalmol 2020 Apr 10;20(1):142. Epub 2020 Apr 10.

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, 420 Delaware Street Southeast, MMC 493, Minneapolis, MN, 55455, USA.

Background: Endophthalmitis is a rare but potentially devastating complication of intravitreal injection. The causative organism plays an important role in prognosis following endophthalmitis. Here we present the first reported case of Turicella otitidis endophthalmitis, which is notable for a delayed presentation. Read More

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http://dx.doi.org/10.1186/s12886-020-01412-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146956PMC

A febrile old man with xanthochromic hypoglycorrhachia.

Germs 2020 Mar 2;10(1):55-57. Epub 2020 Mar 2.

MD, Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan.

Introduction: Meningitis is a commonly seen disease in the daily practice of emergency departments. Cerebrospinal fluid (CSF) examination including Gram stain and culture are crucial for identifying between bacterial and viral meningitis and should be completed prior to antibiotic administration. Hypoglycorrhachia is one of the certain independent predictors of bacterial meningitis. Read More

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http://dx.doi.org/10.18683/germs.2020.1186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117881PMC

Endogenous endophthalmitis caused by group B streptococcus; case reports and review of 35 reported cases.

BMC Ophthalmol 2020 Mar 31;20(1):126. Epub 2020 Mar 31.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

Background: Group B streptococcus (GBS), a gram-positive coccus that occasionally causes neonatal sepsis or invasive infection in the elderly, has been considered a rare cause of endogenous bacterial endophthalmitis (EBE). However, the number of invasive GBS infections is increasing, particularly in elderly patients with underlying conditions such as diabetes mellitus (DM), cardiovascular disease and cancer. We report 6 cases of EBE caused by GBS and review the literature. Read More

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http://dx.doi.org/10.1186/s12886-020-01378-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110777PMC

Prognostic utility of whole genome sequencing and polymerase chain reaction tests of ocular fluids in post-procedural endophthalmitis.

Am J Ophthalmol 2020 Mar 23. Epub 2020 Mar 23.

Department of Ophthalmology, University of Washington, Seattle WA; Departments of Biological Structure and Pathology, University of Washington, Seattle, WA.

Purpose: To associate detection of potential pathogen DNA in endophthalmitis with clinical outcomes DESIGN: Prospective cohort study METHODS: Patients diagnosed with endophthalmitis following an intraocular procedure were recruited. Clinical outcome data from baseline, week 1, month 1 and month 3 visits were collected. Intraocular biopsy samples were cultured by standard methods. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.03.008DOI Listing
March 2020
3.871 Impact Factor

Polymicrobial infection confined to Ahmed glaucoma shunt.

Am J Ophthalmol Case Rep 2020 Jun 16;18:100596. Epub 2020 Jan 16.

Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, USA.

Purpose: To present a case of a unique complication of an Ahmed glaucoma shunt. The pathological and immunohistochemical findings will also be discussed.

Observations: A 58-year-old woman with glaucoma secondary to Marfan syndrome and cataract surgery developed exposure of an Ahmed glaucoma tube, intraluminal white inflammatory material, and low-grade endophthalmitis five years after insertion. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076141PMC

Unusual case of endophthalmitis: Case report and literature review.

Oman J Ophthalmol 2020 Jan-Apr;13(1):37-39. Epub 2020 Feb 17.

Department of Ophthalmology, Sultan Qaboos University Hospital, Seeb, Muscat, Sultanate of Oman.

Endophthalmitis is an inflammation of both the anterior and posterior chamber. It is diagnosed clinically and involvement of retina and choroid has been documented. (1) Endophthalmitis is classified into infectious and no-infectious categories. Read More

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http://dx.doi.org/10.4103/ojo.OJO_48_2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050449PMC
February 2020

Toward a chimeric vaccine against multiple isolates of Mycobacteroides - An integrative approach.

Life Sci 2020 Jun 10;250:117541. Epub 2020 Mar 10.

Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, India.

Aim: Nontuberculous mycobacterial (NTM) infection such as endophthalmitis, dacryocystitis, and canaliculitis are pervasive across the globe and are currently managed by antibiotics. However, the recent cases of Mycobacteroides developing drug resistance reported along with the improper practice of medicine intrigued us to explore its genomic and proteomic canvas at a global scale and develop a chimeric vaccine against Mycobacteroides.

Main Methods: We carried out a vivid genomic study on five recently sequenced strains of Mycobacteroides and explored their Pan-core genome/proteome in three different phases. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117541DOI Listing
June 2020
2.702 Impact Factor

S-Layer-Mediated Innate Interactions During Endophthalmitis.

Front Immunol 2020 12;11:215. Epub 2020 Feb 12.

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.

endophthalmitis is a severe intraocular infection. Hallmarks of endophthalmitis include robust inflammation and rapid loss of vision. We reported that the absence of surface layer protein (SLP) significantly blunted endophthalmitis severity. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028758PMC
February 2020

Fulminant Acanthamoeba Endophthalmitis After Cataract Surgery-A Case Report.

Cornea 2020 Feb 14. Epub 2020 Feb 14.

Aravind Eye Hospital and Post-Graduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.

Purpose: To report a case of Acanthamoeba endophthalmitis after an uneventful cataract surgery.

Methods: Description, management, and outcomes of a biopsy-proven case of Acanthamoeba endophthalmitis.

Results: Two days after a routine cataract surgery elsewhere, the patient presented with acute endophthalmitis diagnosed as a bacterial infection based on timing and severity. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002289DOI Listing
February 2020

Changes in Etiology of Uveitis in a Single Center in Japan.

Ocul Immunol Inflamm 2020 Feb 18:1-6. Epub 2020 Feb 18.

Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.

: We investigated the changes in etiology of uveitis at the Uveitis Clinic of Tokyo Medical University Hospital in recent years.: Medical records of patients with uveitis diagnosed between 2011 and 2017 (Group A) and between 2001 and 2007 (Group B) were reviewed.: 1,587 patients in group A and 1,507 patients in group B were analyzed. Read More

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http://dx.doi.org/10.1080/09273948.2019.1709649DOI Listing
February 2020

Analysis of inflammatory mediators in the vitreous humor of eyes with pan-uveitis according to aetiological classification.

Sci Rep 2020 Feb 17;10(1):2783. Epub 2020 Feb 17.

Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Treatment of uveitis is complicated because of its multiple aetiologies and elevation of various inflammatory mediators. To determine the mediators that are elevated in the vitreous humor according to the aetiology of the uveitis, we examined the concentrations of 21 inflammatory cytokines, 7 chemokines, and 5 colony-stimulating/growth factors in vitreous samples from 57 eyes with uveitis associated with intraocular lymphoma (IOL, n = 13), sarcoidosis (n = 15), acute retinal necrosis (ARN, n = 13), or bacterial endophthalmitis (BE, n = 16). Samples from eyes with idiopathic epiretinal membrane (n = 15), which is not associated with uveitis, were examined as controls. Read More

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http://dx.doi.org/10.1038/s41598-020-59666-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026072PMC
February 2020

Injection volume and intracameral moxifloxacin dose.

J Cataract Refract Surg 2020 01;46(1):162-163

Ontario, Canada Sacramento, California, USA.

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http://dx.doi.org/10.1097/j.jcrs.0000000000000007DOI Listing
January 2020

Anti-microbial Effect and in Vivo Ocular Delivery of Ciprofloxacin-loaded Liposome through Rabbit's Eye.

Curr Eye Res 2020 Feb 18:1-7. Epub 2020 Feb 18.

Nanotechnology Research Center, Ahvaz Jundishapur University of Medical, Sciences, Ahvaz, Iran.

: The main purpose of this study was to increase the concentration and bioavailability of Ciprofloxacin (CPX) in the rabbit eye by liposomal formulation.: CPX- loaded liposomes with and without Carbomer 934 (carbomer) were prepared by a thin-layer hydration method. Liposomal formulations after evaluation for characters such as particle size and entrapment efficiency were used in in-vivo experimental for installation into the rabbit's eyes. Read More

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http://dx.doi.org/10.1080/02713683.2020.1728777DOI Listing
February 2020

The cereus matter of Bacillus endophthalmitis.

Exp Eye Res 2020 Apr 4;193:107959. Epub 2020 Feb 4.

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Ophthalmology, Dean McGee Eye Institute, Oklahoma City, OK, USA; Oklahoma Center for Neuroscience, Oklahoma City, OK, USA; Dean A. McGee Eye Institute, Oklahoma City, OK, USA. Electronic address:

Bacillus cereus (B. cereus) endophthalmitis is a devastating intraocular infection primarily associated with post-traumatic injuries. The majority of these infections result in substantial vision loss, if not loss of the eye itself, within 12-48 h. Read More

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http://dx.doi.org/10.1016/j.exer.2020.107959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113113PMC

Retinal vascular inflammatory and occlusive changes in infectious and non-infectious uveitis.

Jpn J Ophthalmol 2020 Mar 3;64(2):150-159. Epub 2020 Feb 3.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.

Purpose: Retinal vasculitis and occlusive changes are important signs of posterior uveitis and are possible diagnostic markers for uveitis. However, the frequency of arteritis and phlebitis in various uveitis entities, including infectious uveitis (IU) and non-infectious uveitis (NIU), have not been systematically investigated.

Study Design: Retrospective. Read More

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http://dx.doi.org/10.1007/s10384-020-00717-4DOI Listing

Role of Sphingomyelinase in the Pathogenesis of Bacillus cereus Infection.

Biol Pharm Bull 2020 ;43(2):250-253

Department of Microbiology and Infection Control Sciences, Kyoto Pharmaceutical University.

Bacillus cereus is well known as a causative agent of food poisoning but it also causes bacteremia and endophthalmitis in nosocomial infections. However, as an environmental bacterium that lives in soil, it is often treated as simple contamination by hospitals. In recent years, highly pathogenic B. Read More

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http://dx.doi.org/10.1248/bpb.b19-00762DOI Listing
January 2020

Uveitis-glaucoma-hyphema syndrome with sclera-fixed posterior-chamber two-haptic intraocular lens in a highly myopic eye: a case report.

BMC Ophthalmol 2020 Jan 10;20(1):22. Epub 2020 Jan 10.

Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, 200031, China.

Background: We report a case of uveitis-glaucoma-hyphema (UGH) syndrome in a highly myopic pseudophakic eye with seemingly normal positioning of a two-haptic intraocular lens (IOL).

Case Presentation: The patient was a 61-year-old woman suffering recurrent episodes of blurred vision, floaters, redness, elevated intraocular pressure (IOP), and pain in the right eye following implantation of a sclera-fixed IOL. The symptoms were alleviated by the systemic and topical administration of IOP-lowering and anti-inflammatory medications. Read More

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http://dx.doi.org/10.1186/s12886-020-1309-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954629PMC
January 2020

Rapid pathogen identification and antimicrobial susceptibility testing in in vitro endophthalmitis with matrix assisted laser desorption-ionization Time-of-Flight Mass Spectrometry and VITEK 2 without prior culture.

PLoS One 2019 30;14(12):e0227071. Epub 2019 Dec 30.

Department of Ophthalmology and Visual Science, The University of Chicago Hospitals and Health System, Chicago, Illinois, United States of America.

Purpose: Prompt clinical diagnosis and initiation of treatment are critical in the management of infectious endophthalmitis. Current methods used to identify causative agents of infectious endophthalmitis are mostly inefficient, owing to suboptimal sensitivity, length, and cost. Matrix Assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) can be used to rapidly identity pathogens without a need for culture. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227071PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936829PMC

Bacterial etiology and antimicrobial resistance trends in ocular infections: A 30-year study, Turin area, Italy.

Eur J Ophthalmol 2019 Dec 25:1120672119896419. Epub 2019 Dec 25.

Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.

Purpose: Bacterial ocular infections can result in loss of all or part of the ocular structures, contributing to a high disability charge. Local surveillance of etiology and susceptibility patterns is crucial for an appropriate empiric management of ocular infections. The aim of this study was to analyze of bacterial spectrum in culture-proven ocular infections and trends of antimicrobial susceptibility patterns. Read More

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http://dx.doi.org/10.1177/1120672119896419DOI Listing
December 2019

Commentary: endophthalmitis: Clinical settings, susceptibility profile, and management outcomes across two decades.

Indian J Ophthalmol 2020 01;68(1):116-117

Department of Vitreo-Retina, Aravind Eye Hospital, Madurai, Tamil Nadu, India.

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http://dx.doi.org/10.4103/ijo.IJO_1527_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951177PMC
January 2020

Impact of radiological diagnostics in the survivor of disseminated Fournier gangrene patient with septic pulmonary embolism.

BMJ Case Rep 2019 Dec 17;12(12). Epub 2019 Dec 17.

Clinical Physiology, King Saud University, Riyadh, Riyadh Province, Saudi Arabia.

A 51-year-old diabetic man diagnosed with prostatic abscess underwent its drainage twice. Following surgery he developed fever and right-sided painless visual loss due to endophthalmitis. To rule out its endogenous source CT scan was done which showed multisystem aetiology and complications. Read More

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http://dx.doi.org/10.1136/bcr-2019-231468DOI Listing
December 2019

Fulminant keratitis: case study and review of literature.

BMJ Case Rep 2019 Dec 3;12(12). Epub 2019 Dec 3.

Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India.

is a low-virulence gram-negative bacillus known to cause various ocular infections such as endophthalmitis, panophthalmitis and keratitis that are usually associated with an underlying risk factor such as peri-partum or postpartum phase, cataract surgery, contact lens use, neurotrophic keratopathy or ocular trauma. We report a case of spontaneously occurring perforated corneal ulcer caused by the organism in a young man managed by penetrating keratoplasty. The course was followed by endophthalmitis with graft infection culminating in phthisis bulbi despite aggressive medical and surgical management. Read More

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http://dx.doi.org/10.1136/bcr-2019-231642DOI Listing
December 2019

Molecular Signatures Related to the Virulence of Bacillus cereus Sensu Lato, a Leading Cause of Devastating Endophthalmitis.

mSystems 2019 Dec 3;4(6). Epub 2019 Dec 3.

School of Ophthalmology and Optometry and Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, China

endophthalmitis is a devastating eye infection that causes rapid blindness through extracellular tissue-destructive exotoxins. Despite its importance, knowledge of the phylogenetic relationships and population structure of intraocular spp. is lacking. Read More

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http://dx.doi.org/10.1128/mSystems.00745-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890933PMC
December 2019

Effectiveness of intraoperative iodine in cataract surgery: cleanliness of the surgical field without preoperative topical antibiotics.

Jpn J Ophthalmol 2020 Jan 27;64(1):37-44. Epub 2019 Nov 27.

Tottori University, Yonago, Japan.

Purpose: To verify the possibility that preoperative topical antibiotics are not essential as long as iodine disinfection is performed during surgery.

Study Design: Crossover equivalence trial.

Patients And Methods: In 204 eyes of 102 patients who underwent routine bilateral cataract surgery, 1 eye was treated with intraoperative iodine, and the other, with preoperative topical antibiotics. Read More

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http://dx.doi.org/10.1007/s10384-019-00703-5DOI Listing
January 2020

Specific PCR and Quantitative Real-Time PCR in Ocular Samples from Acute and Delayed-Onset Postoperative Endophthalmitis.

Am J Ophthalmol 2020 04 23;212:34-42. Epub 2019 Nov 23.

Grenoble Alpes University, Grenoble, France; Department of Ophthalmology, Grenoble Alpes University Hospital, Grenoble, France. Electronic address:

Purpose: Rapid identification of virulent pathogens is essential to strengthen the therapeutic strategy of acute endophthalmitis.

Objectives: This study sought to compare the contribution of a combination of polymerase chain reaction (PCR)-based tests to culture methods, in patients with postoperative endophthalmitis.

Design: Prospective multicenter study diagnostic evaluation. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.11.026DOI Listing

Strabismus Surgery Infection Prophylaxis and Timing of First Postoperative Visit.

J Pediatr Ophthalmol Strabismus 2019 Nov;56(6):354-359

Purpose: To characterize the practice patterns of pediatric ophthalmologists regarding infection prophylaxis for strabismus surgery and timing of the first postoperative visit.

Methods: A ten-question multiple-choice, close-ended questionnaire was e-mailed to members of the American Association for Pediatric Ophthalmology and Strabismus listserv. Survey responses were summarized using frequencies and percentages. Read More

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http://dx.doi.org/10.3928/01913913-20190808-01DOI Listing
November 2019

Microbial profile and antibiotic susceptibility trend in postoperative endophthalmitis: a 12-year review.

J Pak Med Assoc 2019 Nov;69(11):1647-1650

Aga Khan University, Karachi, Pakistan.

Objective: To identify the microbial profile and susceptibility pattern of pathogens responsible for culture-proven postoperative endophthalmitis, and to investigate possible trends in both pathogens and antibiotic sensitivities.

Methods: The retrospective study was conducted at Aga Khan University Hospital, Karachi, and comprised record of ophthalmology patients from January 1, 2005, to December 31, 2016. Culture and sensitivity reports of vitreous and aqueous humor samples from all the patients were retrieved from the medical record section of the hospital. Read More

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http://dx.doi.org/10.5455/JPMA.1902.DOI Listing
November 2019
0.403 Impact Factor

Timely Use of Conventional Vitrectomy and Endoscope-Assisted Vitrectomy for Endophthalmitis Following Open Ocular Trauma: A Retrospective Study of 18 Patients.

Med Sci Monit 2019 Nov 16;25:8628-8636. Epub 2019 Nov 16.

The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (mainland).

BACKGROUND Endophthalmitis, or inflammation of the internal tissues of the eye, may follow trauma and results in loss of vision if not treated promptly. Vitrectomy is used to debride the inflamed vitreous. This retrospective study aimed to compare the outcome from conventional vitrectomy (CV) and endoscope-assisted vitrectomy (EAV) performed for endophthalmitis within five days and 10 days after open ocular trauma. Read More

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http://dx.doi.org/10.12659/MSM.918017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874835PMC
November 2019

Zebrafish are Resistant to Endophthalmitis.

Pathogens 2019 Oct 26;8(4). Epub 2019 Oct 26.

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Gram-positive bacteria remain the leading cause of endophthalmitis, a blinding infectious disease of the eye. Murine models have been widely used for understanding the pathogenesis of bacterial endophthalmitis. In this study, we sought to develop an alternative zebrafish () model for and compare the disease pathobiology to a murine model. Read More

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http://dx.doi.org/10.3390/pathogens8040207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963345PMC
October 2019

Aqueous level abatement profiles of intracameral antibiotics: A comparative mathematical model of moxifloxacin, cefuroxime, and vancomycin with determination of relative efficacies.

J Cataract Refract Surg 2019 11;45(11):1568-1574

Department of Ophthalmology (Modabber), McGill University, Montreal, Quebec, Canada.

Purpose: To create a model of the abatement profiles of the three most commonly employed endophthalmitis prophylaxis intracameral (IC) antibiotics-cefuroxime, vancomycin, and moxifloxacin-to enable comparison of their durations of efficacy against common endophthalmitis pathogens.

Settings: Humber River Hospital and The Eye Foundation of Canada, Toronto, Ontario, the University of Toronto, Ontario, and McGill University, Montreal, Quebec, Canada.

Design: Literature review, as well as review of our clinical experience with 4797 consecutive cases with IC vancomycin, followed by 9185 consecutive cases with IC moxifloxacin. Read More

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http://dx.doi.org/10.1016/j.jcrs.2019.06.009DOI Listing
November 2019
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A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections.

Microorganisms 2019 Nov 7;7(11). Epub 2019 Nov 7.

Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Some tissues of the eye are susceptible to damage due to their exposure to the outside environment and inability to regenerate. Immune privilege, although beneficial to the eye in terms of homeostasis and protection, can be harmful when breached or when an aberrant response occurs in the face of challenge. In this review, we highlight the role of the PMN (polymorphonuclear leukocyte) in different bacterial ocular infections that invade the immune privileged eye at the anterior and posterior segments: keratitis, conjunctivitis, uveitis, and endophthalmitis. Read More

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http://dx.doi.org/10.3390/microorganisms7110537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920826PMC
November 2019