3,597 results match your criteria Endophthalmitis Bacterial


Revisiting systemic treatment of bacterial endophthalmitis: a review of intravitreal penetration of systemic antibiotics.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital of Basel and University of Basel, Basel, Switzerland.

Background: Adjunctive systemic antibiotic therapy for treatment of bacterial endophthalmitis is controversial but common practice due to the severity of the disease. In absence of guidance documents, several antibiotic regimens are being used without applying evidence-based prescribing, thus leading to inappropriate treatment of this serious eye condition.

Objectives: To summarize available data on intravitreal penetration of systemically administered antibiotics and to discuss their usefulness from a microbiological and pharmacological point of view. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.017DOI Listing
February 2019

Impact of antibiotic resistance of pathogens and early vitrectomy on the prognosis of infectious endophthalmitis: a 10-year retrospective study.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211, Eonjuro, Gangnam-gu, Seoul, 135-720, South Korea.

Purpose: Infectious endophthalmitis (IE) is a severe complication that can lead to blindness even with treatment. However, the impact of antibiotic resistance and early vitrectomy on its prognosis has scarcely been documented. This study investigated the impact of antibiotic resistance of pathogen and early vitrectomy on the prognosis of IE. Read More

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http://dx.doi.org/10.1007/s00417-019-04261-xDOI Listing
February 2019

endophthalmitis in a Cuban pediatric patient.

SAGE Open Med Case Rep 2019 30;7:2050313X19827403. Epub 2019 Jan 30.

Pedro Kourí Tropical Medicine Institute, La Habana, Cuba.

Bacterial endophthalmitis is the most severe form of vision-threatening ocular infection. is a primary respiratory pathogen that has been associated with several extrapulmonary manifestation, including ocular infection. In this work, we presented the microbiology diagnosis of an endophalmitis by using a novel A. Read More

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http://dx.doi.org/10.1177/2050313X19827403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354299PMC
January 2019

New insights into culture negative endophthalmitis by unbiased next generation sequencing.

Sci Rep 2019 Jan 29;9(1):844. Epub 2019 Jan 29.

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

The proof-of-concept, study to investigate the presence of microorganisms in presumed infectious endophthalmitis using Next generation sequencing (NGS) was carried out in vitreous biopsies from 34 patients with endophthalmitis, and thirty patients undergoing surgery for non-infectious retinal disorders as controls. Following DNA extraction using the Qiagen mini kit and PCR amplification of the V3-V4 regions of the bacterial 16S rRNA and ITS 2 region of fungus, they samples were sequenced on an Illumina HiSeq 2500 Machine. Paired reads were curated, taxonomically labeled, and filtered. Read More

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http://www.nature.com/articles/s41598-018-37502-w
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http://dx.doi.org/10.1038/s41598-018-37502-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351655PMC
January 2019
3 Reads

Incidence of acute-onset endophthalmitis after separate bilateral cataract surgeries less than 5 days apart.

BMC Ophthalmol 2019 Jan 25;19(1):32. Epub 2019 Jan 25.

Department of Ophthalmology, Xi'an No. 4 Hospital, Shaanxi Eye Hospital, Affiliated Guangren Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.

Purpose: To assess the incidence of acute-onset endophthalmitis after separate bilateral cataract surgeries less than 5 days apart (SBCS5).

Methods: The medical records of all patients who underwent SBCS5 at a single medical center between October 10, 2012 and July 31, 2017 were retrospectively reviewed.

Results: The medical records for treatment of 5374 eyes of 2687 patients were examined. Read More

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http://dx.doi.org/10.1186/s12886-019-1028-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347771PMC
January 2019
6 Reads

Early Pars Plana Vitrectomy for Treatment of Acute Infective Endophthalmitis.

Asia Pac J Ophthalmol (Phila) 2018 Jan 22. Epub 2018 Jan 22.

Retina Unit, Sydney Eye Hospital, Sydney, NSW, Australia.

Purpose: To evaluate the efficacy and safety of early pars plana vitrectomy (PPV) for the treatment of acute infective endophthalmitis, and identify prognostic factors for better visual outcome.

Design: Retrospective cohort study.

Methods: Consecutive patients who underwent early PPV within 72 hours of presentation for the treatment of acute infective bacterial endophthalmitis and presented to a large tertiary referral center in New South Wales, Australia, between January 2009 and December 2013 were included. Read More

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http://www.apjo.org/Apjo/pdf/id/643.html
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http://dx.doi.org/10.22608/APO.2018414DOI Listing
January 2018
5 Reads

The Early Diagnosis of Endophthalmitis Due to Group B Streptococcus Infective Endocarditis and Its Clinical Course: A Case Report and Literature Review.

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, Japan.

A 68-year-old Japanese man was admitted to our hospital with right eye pain, a sudden worsening of his eyesight, and a fever. He was diagnosed with endogenous bacterial endophthalmitis due to infectious endocarditis (IE) of Group B Streptococcus (GBS) on the day of admission. He recovered systemically, but his right eye became phthisical only with the administration of antibiotics. Read More

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http://dx.doi.org/10.2169/internalmedicine.2232-18DOI Listing
January 2019
1 Read

Antibiotic susceptibility, cytotoxicity, and protease activity of viridans group streptococci causing endophthalmitis.

PLoS One 2018 21;13(12):e0209849. Epub 2018 Dec 21.

Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.

The viridans group streptococci comprise multiple species and have gained more recognition in recent years as common etiologic agents of bacterial endophthalmitis. The purpose of this study was to identify the species of human endophthalmitis isolates of viridans streptococci and to characterize their potential virulence attributes. The species of 22 endophthalmitis strains of viridans streptococci were identified by Matrix Assisted Laser Desorption Ionization Time-of-Flight. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209849PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303072PMC
December 2018
8 Reads

Endogenous endophthalmitis caused by a multidrug-resistant hypervirulent Klebsiella pneumoniae strain belonging to a novel single locus variant of ST23: first case report in China.

BMC Infect Dis 2018 Dec 17;18(1):669. Epub 2018 Dec 17.

Department of Respiratory Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: Endogenous endophthalmitis caused by hypervirulent Klebsiella pneumoniae (HVKP) is an emerging infectious disease commonly with a devastating visual outcome. Most HVKP strains display a wild-type susceptibility profile to antibiotics. However, reports of antimicrobial-resistant HVKP have increased over time, which poses a serious therapeutic dilemma. Read More

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http://dx.doi.org/10.1186/s12879-018-3543-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296127PMC
December 2018

The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases.

Interdiscip Perspect Infect Dis 2018 13;2018:2525173. Epub 2018 Nov 13.

Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

is a gram-positive, facultatively anaerobic pathogen that can cause severe infections such as pneumonia, meningitis, septicemia, and middle ear infections. It is also one of the top pathogens contributing to bacterial keratitis and conjunctivitis. Though two pneumococcal vaccines exist for the prevention of nonocular diseases, they do little to fully prevent ocular infections. Read More

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https://www.hindawi.com/journals/ipid/2018/2525173/
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http://dx.doi.org/10.1155/2018/2525173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257906PMC
November 2018
4 Reads

Complete Genome Sequence of Massilia oculi sp. nov. CCUG 43427 (=DSM 26321), the Type Strain of M. oculi, and Comparison with Genome Sequences of Other Massilia Strains.

Curr Microbiol 2018 Nov 15. Epub 2018 Nov 15.

Key Laboratory of Urban Agriculture by Ministry of Agriculture of China, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.

Massilia oculi sp. nov. of type strain CCUG 43427 is a Gram-negative, rod-shaped, nonspore-forming bacterium, which was recently isolated from the eye of a patient suffering from endophthalmitis and was described as novel species in Massilia genus. Read More

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http://dx.doi.org/10.1007/s00284-018-1597-7DOI Listing
November 2018
1 Read

[Vitrectomy for endophthalmitis : Incubation time and prognosis following intravitreal injection vs. cataract surgery].

Ophthalmologe 2018 Nov 12. Epub 2018 Nov 12.

Klinik für Augenheilkunde, Akademisches Lehrkrankenhaus der Johannes Gutenberg-Universität Mainz und der Medizinischen Fakultät Mannheim der Universität Heidelberg, Klinikum Ludwigshafen am Rhein, Bremserstr. 79, 67063, Ludwigshafen am Rhein, Deutschland.

Background: Bacterial endophthalmitis is a rare but devastating complication following intraocular surgery. Guidelines on the diagnostics and treatment are based mainly on experience of endophthalmitis treatment following cataract surgery.

Objective: In this study we analyzed infectious endophthalmitis cases following either intravitreal operative drug injection (IVOM) or cataract surgery for possible differences in the clinical course and prognosis. Read More

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http://dx.doi.org/10.1007/s00347-018-0816-8DOI Listing
November 2018
2 Reads

Orbital Cellulitis: Clinical Manifestations and Outcomes in a Tertiary Medical Center in Taiwan.

J Ophthalmol 2018 2;2018:4237573. Epub 2018 Oct 2.

Department of Ophthalmology, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan.

Purpose: To report six cases of orbital cellulitis without preceding endophthalmitis.

Method: Retrospective chart review.

Results: We reported four females and two males admitted to our hospital for orbital cellulitis proven by computed tomographies and bacterial cultures from May 1995 to March 2017. Read More

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https://www.hindawi.com/journals/joph/2018/4237573/
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http://dx.doi.org/10.1155/2018/4237573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189659PMC
October 2018
10 Reads

Genetic diversity and persistent colonization of Enterococcus faecalis on ocular surfaces.

Jpn J Ophthalmol 2018 Nov 15;62(6):699-705. Epub 2018 Oct 15.

Department of Ophthalmology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Purpose: Enterococcus faecalis causes severe acute endophthalmitis and often leads to poor visual outcomes. Conjunctival bacterial cultures occasionally grow atypical bacteria including E. faecalis, which can potentially contribute to the development of postoperative endophthalmitis. Read More

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http://link.springer.com/10.1007/s10384-018-0630-5
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http://dx.doi.org/10.1007/s10384-018-0630-5DOI Listing
November 2018
16 Reads

Chronic postcataract endophthalmitis caused by species in an immunocompetent patient.

Int Med Case Rep J 2018 8;11:259-262. Epub 2018 Oct 8.

Department of Ophthalmology, National Defense Medical College, Tokorozawa, Japan,

Objective: species are abundant, generally saprophytic, and widely distributed in the environment. On rare occasions, they cause endophthalmitis in immunocompromised patients or in immunocompetent patients with uncontrolled diabetic mellitus or immunosuppressive agents. We report a case of endophthalmitis caused by species in an immunocompetent patient without any disorders. Read More

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https://www.dovepress.com/chronic-postcataract-endophthalmit
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http://dx.doi.org/10.2147/IMCRJ.S175374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181112PMC
October 2018
12 Reads

Utility of broad-range 16S rRNA PCR assay versus conventional methods for laboratory diagnosis of bacterial endophthalmitis in a tertiary care hospital.

Br J Ophthalmol 2019 Jan 12;103(1):152-156. Epub 2018 Oct 12.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Endophthalmitis, a sight-threatening intraocular infection, can be of postsurgical, post-traumatic or endogenous origin. Laboratory diagnosis-based appropriate therapy can be vision-saving. Conventional culture-based laboratory diagnosis takes time and lacks sensitivity. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3128
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http://dx.doi.org/10.1136/bjophthalmol-2018-312877DOI Listing
January 2019
2 Reads

Filamentous gram-negative bacteria masquerading as actinomycetes in infectious endophthalmitis: a review of three cases.

J Ophthalmic Inflamm Infect 2018 Oct 11;8(1):15. Epub 2018 Oct 11.

Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L. V. Prasad Eye Institute, Hyderabad, India.

Background: To report microbiological diagnostic dilemma posed by observation of unusual morphology of bacteria in the vitreous sample of a series of three cases of bacterial endophthalmitis.

Results: A non-comparative, descriptive case series is described. All three cases presented to the retina-vitreous clinic with a clinical diagnosis of acute endophthalmitis between January and April 2018. Read More

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https://joii-journal.springeropen.com/articles/10.1186/s1234
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http://dx.doi.org/10.1186/s12348-018-0157-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179972PMC
October 2018
6 Reads

Antibiotic resistance profile in eye infections in a reference centre in Floridablanca, Colombia.

Arch Soc Esp Oftalmol 2019 Jan 27;94(1):4-11. Epub 2018 Sep 27.

Centro Oftalmológico Virgilio Galvis, Floridablanca, Colombia.

Background And Objective: In view of the increasing bacterial resistance to antibiotics, it is necessary to determine it locally in order to serve as a guide in clinical management. The purpose of this study was to characterise the pattern of antibiotic sensitivity in cases of eye infections in a third level ophthalmological institution in Floridablanca (Colombia).

Materials And Methods: An observational cross-sectional study in which an analysis was made of the culture and antibiogram reports of specimens taken from cases of conjunctivitis, infectious keratitis, and endophthalmitis between January 2013 and June 2016. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.07.003DOI Listing
January 2019
1 Read

Endogenous bacterial endophthalmitis and subretinal abscess complicating diabetic ketoacidosis.

BMJ Case Rep 2018 Sep 18;2018. Epub 2018 Sep 18.

Ophthalmology Department, King's College Hospital NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1136/bcr-2018-227025DOI Listing
September 2018
4 Reads

Successful treatment of endogenous endophthalmitis with extensive subretinal abscess: a case report.

BMC Ophthalmol 2018 Sep 5;18(1):238. Epub 2018 Sep 5.

Departments of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.

Background: Endogenous endophthalmitis could lead to a devastating outcome without a prompt and appropriate management. We report a case of advanced endogenous Klebsiella pneumoniae endophthalmitis with extensive subretinal abscess that was successfully treated with a vitrectomy.

Case Presentation: A systemically well 61-year-old man complained of ocular pain and visual decrease in his right eye for eighteen days. Read More

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http://dx.doi.org/10.1186/s12886-018-0908-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125994PMC
September 2018
12 Reads

Disseminated Nocardiosis with subretinal abscess in a patient with nephrotic syndrome-a case report.

BMC Ophthalmol 2018 Sep 3;18(1):234. Epub 2018 Sep 3.

Departments of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.

Background: Nocardia infection is uncommon in clinical practice, with most cases occuring as the result of opportunistic infection in immunocompromsed patients. Here, we report a case of disseminated nocardiosis with subretinal abscess in a patient with nephrotic syndrome, and whom is receiving immunosuppressive therapy.

Case Presentation: A 58-year-old male presented with decreased vision in his left eye, without redness or floaters, which had persisted for three days. Read More

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http://dx.doi.org/10.1186/s12886-018-0883-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122714PMC
September 2018
2 Reads

Noninfectious Inflammatory Response following Intravitreal Bevacizumab Injections: Description of a Cluster of Cases in Two Centers and a Review of the Literature.

Ophthalmologica 2018 31;240(3):163-166. Epub 2018 Aug 31.

Department of Ophthalmology, Tel-Aviv Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Purpose: To report a cluster of high incidence of noninfectious inflammatory reaction shortly after bevacizumab injection.

Methods: Data were collected from medical records of consecutive patients who underwent bevacizumab injections and presented with acute uveitis within 1-4 days.

Results: All 7 patients were injected intravitreally with bevacizumab from different batches and presented with visual deterioration. Read More

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http://dx.doi.org/10.1159/000492681DOI Listing
October 2018
12 Reads

Identification and Visualization of a Distinct Microbiome in Ocular Surface Conjunctival Tissue.

Invest Ophthalmol Vis Sci 2018 Aug;59(10):4268-4276

School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia.

Purpose: Knowledge of whether microorganisms reside in protected niches of the conjunctiva is potentially significant in terms of minimizing risks of contact lens inflammation/infection and endophthalmitis. We define if and how microbial communities from limbal and forniceal conjunctival tissue differ from those on the conjunctival surface.

Methods: Human limbal and forniceal conjunctival tissue was obtained from 23 patients undergoing pterygium surgery and analyzed with data from a recent study of conjunctival surface swabs (n = 45). Read More

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http://dx.doi.org/10.1167/iovs.18-24651DOI Listing
August 2018
13 Reads

Outcomes of combined keratoplasty and pars plana vitrectomy for endophthalmitis with compromised corneal clarity.

Clin Exp Ophthalmol 2019 Jan 23;47(1):49-56. Epub 2018 Aug 23.

Dr. Shroff's Charity Eye Hospital, New Delhi, India.

Importance: Studies evaluating combined penetrating keratoplasty and pars plana vitrectomy for infectious aetiologies are limited.

Background: To evaluate the outcomes of combined penetrating keratoplasty and pars plana vitrectomy in patients with endophthalmitis and poor corneal clarity.

Design: Retrospective interventional case series conducted at a tertiary care eye hospital in North India. Read More

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http://dx.doi.org/10.1111/ceo.13370DOI Listing
January 2019
3 Reads

Epidemiology of uveitis (2013-2015) and changes in the patterns of uveitis (2004-2015) in the central Tokyo area: a retrospective study.

BMC Ophthalmol 2018 Aug 2;18(1):189. Epub 2018 Aug 2.

Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: The distribution of uveitis varies with genetic, ethnic, geographic, environmental, and lifestyle factors. Epidemiological information about the patterns of uveitis is useful when an ophthalmologist considers the diagnosis of uveitis. Therefore, it is important to identify the causes of uveitis over the years in different regions. Read More

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http://dx.doi.org/10.1186/s12886-018-0871-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090933PMC
August 2018
2 Reads

Community-acquired group B streptococcal meningitis in adults: 33 cases from prospective cohort studies.

J Infect 2019 Jan 29;78(1):54-57. Epub 2018 Jul 29.

Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience, Meibergdreef 9, The Netherlands. Electronic address:

Objectives: Streptococcus agalactiae (group B streptococcus, GBS) is an uncommon cause of bacterial meningitis in adults. We describe clinical characteristics, serotype distribution and outcome of adult GBS meningitis.

Patients And Methods: Patients aged 16 years or older with GBS cultured in cerebrospinal fluid included in two prospective nationwide cohort studies performed in the Netherlands between 1998-2002 and 2006-2017 were evaluated. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.07.009DOI Listing
January 2019
4 Reads

Ocular culture-proven endogenous endophthalmitis: a 5-year retrospective study of the microorganism spectrum at a tertiary referral center in Turkey.

Int Ophthalmol 2018 Jul 26. Epub 2018 Jul 26.

Department of Ophthalmology, Marmara University School of Medicine, Fevzi Çakmak Mah. Muhsin Yazıcıoğlu Cad. No:10, Pendik/Istanbul, Turkey.

Purpose: The aim of this study was to review the clinical profile of endogenous endophthalmitis (EE), including predisposing systemic conditions, responsible microorganisms, clinical presentations, and outcomes.

Methods: We reviewed data from 21 eyes of 15 patients diagnosed with EE and compared their clinical characteristics over a 5-year period. All patients were ocular fluid cultures proven. Read More

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http://dx.doi.org/10.1007/s10792-018-0997-9DOI Listing
July 2018
1 Read

Bacterial endogenous endophthalmitis after colonoscopy.

Rev Esp Enferm Dig 2018 Sep;110(9):601

Aparato Digestivo, Hospital San Agustín, España.

We report a case with bacterial endogenous endophthalmitis caused by Streptococcus bovis, developed after colonoscopy, which had a poor outcome and resulted in evisceration. Bacterial endogenous endophthalmitis is a rare, but serious ocular disease that occurs when bacteria from a primary focus reach the eye. It requires a very early diagnosis. Read More

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http://dx.doi.org/10.17235/reed.2018.5658/2018DOI Listing
September 2018

Postoperative endophthalmitis due to : First reported case of acute and virulent presentation from a tertiary eye care center in South India.

Indian J Ophthalmol 2018 08;66(8):1200-1202

Jaslok Community Ophthalmic Centre, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India.

A 60-year-old male presented with pain and decreased vision 3 weeks following uneventful intracapsular cataract extraction with anterior vitrectomy for subluxated cataract. A diagnosis of acute endophthalmitis was made based on clinical and ultrasound features. Patient improved only after undergoing pars plana vitrectomies twice and repeated intravitreal antibiotic-steroid injections. Read More

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http://dx.doi.org/10.4103/ijo.IJO_242_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080441PMC
August 2018
4 Reads

Commentary: The changing scenario of cluster endophthalmitis.

Indian J Ophthalmol 2018 08;66(8):1079

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.4103/ijo.IJO_530_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080435PMC

Recommendations for an expert team investigating a case of cluster endophthalmitis.

Indian J Ophthalmol 2018 08;66(8):1074-1078

Cornea Clinic, M & J Western Regional Institute of Ophthalmology, Ahmedabad, Gujarat, India.

Occurrence of postoperative cluster endophthalmitis is a nightmare for the operating surgeon, the involved hospital, and the patients. Due to its multifactorial etiology, surveillance of such an event is extremely important to identify the causative factor and to prevent recurrences in future. For surveillance, a team of ophthalmologists and microbiologists is often appointed by the local health department, and it is imperative that this team investigates thoroughly, reports appropriately safeguarding the interests of all, and also suggests remedial measures for future. Read More

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http://dx.doi.org/10.4103/ijo.IJO_804_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080468PMC
August 2018
13 Reads

Clinical Analysis of 1593 Patients with Infectious Endophthalmitis: A 12-Year Study at a Tertiary Referral Center in Western China.

Chin Med J (Engl) 2018 Jul;131(14):1658-1665

Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.

Background: Infectious endophthalmitis is a severe ocular inflammation which can cause devastating visual loss. The aim of the study was to identify the demographic and clinical features of infectious endophthalmitis in Western China for better prophylaxis and treatment of this disease.

Methods: A. Read More

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http://dx.doi.org/10.4103/0366-6999.235866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048916PMC
July 2018
12 Reads

Preoperative preparation of eye with chlorhexidine solution significantly reduces bacterial load prior to 23-gauge vitrectomy in Swedish health care.

BMC Ophthalmol 2018 Jul 11;18(1):167. Epub 2018 Jul 11.

Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Background: Bacteria in the conjunctiva present a potential risk of vitreous cavity infection during 23-gauge pars plana vitrectomy (PPV). Current preoperative procedures used in Sweden include irrigation with chlorhexidine solution (CHX) 0.05% only and no iodine solutions. Read More

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http://dx.doi.org/10.1186/s12886-018-0844-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042411PMC
July 2018
6 Reads

Fulminant eye infection in a patient with nephrotic syndrome.

Clin Case Rep 2018 Jul 28;6(7):1385-1386. Epub 2018 May 28.

Division of Nephrology, Hypertension and Renal Transplantation University of Florida Gainesville FL USA.

Endophthalmitis is a bacterial or fungal infection inside the eye, involving the vitreous and/or aqueous humors. High index of suspicion is required for this condition in immunocompromised patients with ocular complaints as it can worsen rapidly and lead to permanent loss of vision. Read More

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http://dx.doi.org/10.1002/ccr3.1610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028373PMC

Analysis of pharmaceuticals and small molecules in aqueous humor.

J Pharm Biomed Anal 2018 Sep 25;159:23-36. Epub 2018 Jun 25.

Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland. Electronic address:

Aqueous humor (AH) is a transparent fluid found in the anterior chamber of the eye. The circulating AH nourishes the cornea and lens and removes the metabolic waste moving through the ocular chambers and drains from the eye to the venous blood. Analysis of drugs in AH is necessary to evaluate their pharmacokinetics parameters, which may be crucial to avoid potential adverse effects. Read More

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http://dx.doi.org/10.1016/j.jpba.2018.06.049DOI Listing
September 2018
15 Reads

Incidence and characteristics of acute-onset postoperative bacterial and sterile endophthalmitis in dogs following elective phacoemulsification: 1,447 cases (1995-2015).

J Am Vet Med Assoc 2018 Jul;253(2):201-208

OBJECTIVE To characterize and determine the incidence of acute-onset (ie, developing ≤ 6 weeks after surgery) postoperative infectious and sterile endophthalmitis in dogs following elective cataract surgery. DESIGN Retrospective case series. ANIMALS 2,630 eyes of 1,447 dogs that underwent elective unilateral or bilateral cataract surgery by phacoemulsification at Cornell University from 1995 through 2015. Read More

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https://avmajournals.avma.org/doi/10.2460/javma.253.2.201
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http://dx.doi.org/10.2460/javma.253.2.201DOI Listing
July 2018
15 Reads

Postsurgical Cataract Prophylaxis With Intravitreal "Triamcinolone-Moxifloxacin" May Not Be Optimal For Preventing Endophthalmitis.

Eye Contact Lens 2018 Nov;44 Suppl 2:S338-S343

The Charles T. Campbell Ophthalmic Microbiology Laboratory, Department of Ophthalmology, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA.

Purpose: Intravitreal injections of antibiotics and anti-inflammatories are used by some cataract surgeons for surgical prophylaxis. To support this prophylaxis, intravitreal triamcinolone-moxifloxacin (TM) and triamcinolone-moxifloxacin-vancomycin (TMV) were tested for preventing Staphylococcus aureus (SA) endophthalmitis in rabbits.

Methods: Trademark formulations of TM (15/1 mg/mL) and TMV (15/1/10 mg/mL) were intravitreally injected into seven groups of eight rabbits each (A-G). Read More

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http://Insights.ovid.com/crossref?an=00140068-900000000-9923
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http://dx.doi.org/10.1097/ICL.0000000000000488DOI Listing
November 2018
10 Reads

Endogenous endophthalmitis with subretinal abscess in a HIV-infected man.

Indian J Ophthalmol 2018 07;66(7):1015-1017

Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

To report a rare case of Cryptococcus neoformans endogenous endophthalmitis with subretinal abscess in a 36-year-old HIV-positive man, referred with progressive blurred vision in his right eye for the last 6 months. Vitreous biopsy followed by intravitreal ganciclovir did not result in significant improvement. Microbiology revealed the presence of C. Read More

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http://dx.doi.org/10.4103/ijo.IJO_60_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032738PMC
July 2018
6 Reads

Incidence and Outcomes of Positive Donor Rim Cultures and Infections in the Cornea Preservation Time Study.

Cornea 2018 Sep;37(9):1102-1109

Department of Ophthalmology and Visual Sciences, Case Western Reserve University, University Hospitals Eye Institute, Cleveland, OH.

Purpose: To assess donor rim culture results and outcomes of ocular infections in the Cornea Preservation Time Study (CPTS).

Methods: Donor corneal rim cultures were optional. Donor characteristics were assessed for association with positive cultures using the Fisher exact test and Poisson regression analyses. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081243PMC
September 2018
9 Reads

Bacterial Flora of the Conjunctiva One Year after Dacryocystorhinostomy.

Middle East Afr J Ophthalmol 2018 Jan-Mar;25(1):35-39

Department of Ophthalmology, Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: The purpose of this study was to evaluate the changes of conjunctival bacterial flora 1 year after successful dacryocystorhinostomy (DCR).

Methods: Seventy-two consecutive adult patients with successful DCR were enrolled in this study. We obtained conjunctival cultures from the operated eyes, fellow eyes, and nasal mucosa of the operated side 1 year after the operation. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_225_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974816PMC
August 2018
4 Reads

Antibiotic prophylaxis for preventing endophthalmitis after intravitreal injection: a systematic review.

Eye (Lond) 2018 09 11;32(9):1423-1431. Epub 2018 Jun 11.

Department of Ophthalmology, University of Florence, A.O.U.C, Florence, Italy.

Purpose: To assess the effect of topical antibiotic prophylaxis on the rate of post-operative endophthalmitis after intravitreal injection (IVI).

Methods: We conducted a systematic review of studies comparing the rates of endophthalmitis in eyes receiving IVI of different drugs with and without topical antibiotic prophylaxis, by searching MEDLINE and EMBASE up to June 2016. The methodological quality of the included studies was assessed using the Cochrane Risk of Bias tool and the Risk Of Bias in Non-randomized Studies of Interventions (ROBINS-I) for randomized clinical trials (RCTs) and non-randomized studies, respectively. Read More

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http://dx.doi.org/10.1038/s41433-018-0138-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137222PMC
September 2018
18 Reads

Another perspective on the treatment of postoperative endophthalmitis: Unclear evidence for the role of vitrectomy.

Acta Ophthalmol 2018 Dec 4;96(8):e1042-e1043. Epub 2018 Jun 4.

Infectious diseases, RIVM, Bilthoven, Utrecht, The Netherlands.

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http://dx.doi.org/10.1111/aos.13810DOI Listing
December 2018
4 Reads

Intracameral moxifloxacin after cataract surgery: a prospective study.

Arq Bras Oftalmol 2018 Apr;81(2):92-94

Universidade Federal de Pernambuco, Recife, PE, Brazil.

Objective: To study the safety parameters associated with intracameral moxifloxacin application five weeks after cataract surgery.

Methods: The study was a prospective case series set in a private hospital in Recife, Pernambuco, Brazil. A consecutive sample of 1,016 cataract surgeries was evaluated. Read More

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http://dx.doi.org/10.5935/0004-2749.20180022DOI Listing
April 2018
4 Reads

A cluster of nontuberculous mycobacterial endophthalmitis (NTME) cases after cataract surgery: clinical features and treatment outcomes.

Eye (Lond) 2018 09 29;32(9):1504-1511. Epub 2018 May 29.

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Purpose: To report the clinical features and treatment outcomes in a cluster of patients with endophthalmitis after cataract surgery caused by nontuberculous mycobacterium.

Patients And Methods: Retrospective chart review and noncomparative, consecutive case series. Nine consecutive cases of endophthalmitis, after cataract surgery in a local clinic, were referred to our hospital. Read More

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http://dx.doi.org/10.1038/s41433-018-0108-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137041PMC
September 2018
26 Reads

[Endophthalmitis].

Authors:
Thomas Neß

Ophthalmologe 2018 Aug;115(8):697-706

Klinik für Augenheilkunde, Medizinische Fakultät, Universitätsklinikum Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.

Endophthalmitis is a severe intraocular infection with potentially devastating consequences, such as becoming blind or loss of an eyeball. It can be exogenous (postoperative or posttraumatic) or endogenous. The most frequent causes of postoperative endophthalmitis are cataract surgery and intravitreal injections. Read More

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http://dx.doi.org/10.1007/s00347-018-0729-6DOI Listing
August 2018
1 Read

All India Ophthalmological Society members survey results: Cataract surgery antibiotic prophylaxis current practice pattern 2017.

Indian J Ophthalmol 2018 06;66(6):820-824

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: The purpose of this article is to document the current practice pattern of Indian ophthalmologists for antibiotic prophylaxis in cataract surgery to prevent endophthalmitis.

Methods: Fifteen structured questions were sent online to all ophthalmologists registered with the All India Ophthalmological Society. The questionnaire was divided into three main categories of prophylaxis - preoperative, intraoperative, and postoperative. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1336_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989505PMC
June 2018
6 Reads

Povidone-iodine concentration and dosing in cataract surgery.

Surv Ophthalmol 2018 Nov - Dec;63(6):862-868. Epub 2018 May 18.

The Lions Eye Institute, Department of Ophthalmology, Albany Medical College, Albany, New York, USA.

Iodine has been recognized as an effective bactericide since the 1800s, and povidone-iodine (PI) solution has been applied to the ocular surface and periocular skin since the 1980s to prevent endophthalmitis in cataract surgery. In vitro, PI solution kills bacteria quickly at dilute concentrations (0.05%-1. Read More

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http://dx.doi.org/10.1016/j.survophthal.2018.05.002DOI Listing
November 2018
14 Reads

Panophthalmitis caused by Streptococcus dysgalactiae subsp. equisimilis: A case report and literature review.

J Infect Chemother 2018 Nov 8;24(11):936-940. Epub 2018 May 8.

Division of Infection Control and Prevention, Osaka University Hospital, Japan.

Lancefield group G β-hemolytic Streptococcus dysgalactiae subspecies equisimilis (SDSE) has become a leading causative pathogen of invasive streptococcal infection. In this report, we describe a case of disseminated SDSE infection complicated by endogenous endophthalmitis, resulting in panophthalmitis and blindness. A 65-year-old man who underwent mitral valve replacement surgery two months previously was hospitalized due to high fever and right visual loss. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.04.012DOI Listing
November 2018
1 Read

Endophthalmitis caused by Fusarium: An emerging problem in patients with corneal trauma. A case series.

Rev Iberoam Micol 2018 Apr - Jun;35(2):92-96. Epub 2018 Apr 30.

Microbiology Service, Araba University Hospital, Vitoria-Gasteiz, Araba, Spain.

Background: Although fortunately very rare in countries with a temperate climate, certain factors, such as clinical or pharmacological immunosuppression, may cause Fusarium-related fungal infections to become an emerging problem. Moreover, Fusarium is one of the most important etiological agents in exogenous endophthalmitis, which is often favored by the disruption of the epithelial barriers.

Aims: The aim of this series of clinical cases is to identify characteristic clinical findings that may allow an early diagnosis and more efficient management of this ophthalmologic emergency. Read More

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http://dx.doi.org/10.1016/j.riam.2017.09.007DOI Listing
January 2019
1 Read