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Curr Med Mycol 2021 Dec;7(4):43-48

Microbiology Department, All India Institute of Medical Sciences, New Delhi, India.

Background And Purpose: Although and are more commonly implicated with ocular infections; there are some saprophytic species, such as () which may occasionally lead to serious ocular infections. There is a paucity of data on ocular infections caused by . We report a case series of three ophthalmic infections caused by from a tertiary care eye center in North India. Read More

SAGE Open Med Case Rep 2022 16;10:2050313X221105157. Epub 2022 Jun 16.

Department of Surgery, Faculty of Medicine, University of Colombo, Sri Lanka, Colombo, Sri Lanka.

, found in the gastrointestinal flora is a causative agent of hospital-acquired infections. Although isolated organ infections are common, reports of multi-system involvement are rare. We report on a susceptible patient presenting with disseminated infection with concurrent multi-organ disease involving the lung, liver, prostate and eye. Read More

Eye (Lond) 2022 Jun 23. Epub 2022 Jun 23.

Department of Ophthalmology, Tung Wah Eastern Hospital Causeway Bay, Hong Kong, Hong Kong.

Objectives: This study reports the surgical outcomes of evisceration with primary orbital implant placement in patients with endophthalmitis and analyses the association with implant exposure and extrusion.

Methods: A retrospective, multicentre, Chinese cohort study. Review of medical records and orbital images of patients who underwent evisceration with primary orbital implant placement between January 2005 and January 2021. Read More

Vector Borne Zoonotic Dis 2022 Jun 23. Epub 2022 Jun 23.

The Fifth People's Hospital of Anyang, Anyang, China.

Pseudorabies virus (PRV) is a common pathogen found in pigs. The pathogenicity of PRV in humans is under researched and there are few confirmed cases of PRV infections in humans, which has led to a lack of clinical consensus. We presented a case of viral encephalitis caused by PRV in China. Read More

J Fungi (Basel) 2022 Jun 16;8(6). Epub 2022 Jun 16.

Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.

Endogenous fungal endophthalmitis (EFE) is a vision-threatening intraocular infection and a rare complication of fungemia. Early diagnosis and prompt aggressive treatment are crucial to avoid vision loss. We retrospectively reviewed the data of 37 patients (49 eyes) with EFE who were treated at a tertiary referral hospital from January 2000 to April 2019. Read More

Arq Bras Oftalmol 2022 May-Jun;85(3):324-326

Department of Ophthalmology, Complejo Asistencial Universitario de Palencia, Palencia, Spain.

Br J Ophthalmol 2022 Jun 21. Epub 2022 Jun 21.

Department of Ophthalmology, Kagoshima City Hospital, Kagoshima, Japan.

Background/aims: To determine the incidence and causative pathogens of endophthalmitis after vitrectomy during strict face mask wearing in the COVID-19 period.

Methods: This was a retrospective multicentre study including 31 ophthalmological institutions of the Japanese Retina and Vitreous Society or Japan-Clinical Retina Study group. Patients who had undergone vitrectomy during 2019, the pre-COVID-19 period, and from July 2020 to June 2021, the COVID-mask period, were studied. Read More

Int J Retina Vitreous 2022 Jun 17;8(1):41. Epub 2022 Jun 17.

Department of Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil.

Background: Noninfectious endophthalmitis may be misdiagnosed, leading to serious clinical implications. So far, its causative factors remain unknown. Therefore, this study assessed the role of silicone oil and syringe agitation in the development of inflammation after intravitreal injection of aflibercept. Read More

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Clinical Microbiology, HSE, Dublin, Ireland.

Endophthalmitis is a rare but sight-threatening manifestation of systemic infection. Immunosuppression is a well-recognised risk factor for development of endophthalmitis. Determining the aetiology can be complex, particularly in the context of immunosuppression, we present the diagnostic and treatment dilemmas associated with a patient who complains of blurred vision 2 weeks following an allogeneic stem cell transplant for refractory Hodgkin's disease. Read More

Eur J Ophthalmol 2022 Jun 17:11206721221107311. Epub 2022 Jun 17.

Department of Ophthalmology, 74639Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Purpose: To evaluate the efficacy of metagenomic next-generation sequencing (mNGS) and to explore its value in the diagnosis of intraocular infection.

Methods: A retrospective case-series study of patients with suspected intraocular infection was performed. Intraocular fluid samples were collected from all the patients and sent for mNGS. Read More

Infect Drug Resist 2022 10;15:3005-3012. Epub 2022 Jun 10.

Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China.

Purpose: To describe the etiology and spectrum of isolated pathogens in endophthalmitis over 10 years from an ophthalmic hospital in North China and report their antimicrobial susceptibilities.

Patients And Methods: The data covered the patients with endophthalmitis treated at Qingdao Eye Hospital from January 2011 to December 2020. Patients' medical history, pathogenic factors, bacterial and fungal culture results of intraocular specimens, and in vitro drug sensitivity test results were assessed. Read More

Bioact Mater 2023 Feb 2;20:271-285. Epub 2022 Jun 2.

Eye Center, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR China.

Postoperative endophthalmitis (POE) has been the most threatening complication after cataract surgery, which perhaps can be solved by the antibiotic-loaded intraocular lens (IOL). However, most drug-loaded IOLs demonstrate insufficient drug quantity, short release time, increased implantation-related difficulties or other noticeable drawbacks. To prevent POE and to address these deficiencies, a drug-loaded copolymer IOL, prepared from poly (urethane acrylate) prepolymer, isobornyl methacrylate (IBOMA), N-vinyl-2-pyrrolidone (NVP), Irgacure 819, RUVA-93, and gatifloxacin (GAT), was rapidly fabricated via photocuring and by using a 3D-printed mold. Read More

Case Rep Ophthalmol 2022 Jan-Apr;13(1):318-322. Epub 2022 Apr 28.

The Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA.

We report a case of endophthalmitis occurring secondary to a retained cilium in a clear corneal wound after cataract surgery. A 67-year-old female presented to an ophthalmology emergency room with light perception vision in the right eye 5 days after routine cataract surgery. Examination of the right eye demonstrated decreased vision, conjunctival injection, a corneal endoplaque, and anterior chamber fibrin. Read More

Clin Pract Cases Emerg Med 2022 May;6(2):180-182

Eisenhower Health, Department of Emergency Medicine, Rancho Mirage, California.

Case Presentation: An 88-year-old female presented to the emergency department (ED) with complaints of painful vision loss four days after an intravitreal injection for her neovascular macular degeneration. Her right eye visual acuity was markedly diminished with an absence of red reflex. A point-of-care ocular ultrasound was performed and demonstrated hyperechoic vitreous debris concerning for endophthalmitis. Read More

Precis Clin Med 2019 Dec 29;2(4):283-287. Epub 2019 Nov 29.

Eye Institute, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.

A 54-year-old woman presented with recurrent redness and blurred vision of the left eye with elevated intraocular pressure (IOP) for one year. She was treated as "iridocyclitis" and ``Posner-Schlossman syndrome'' at the local hospitals. However, the patient developed intermittent ocular inflammation and hyphema. Read More

Front Pharmacol 2022 24;13:919688. Epub 2022 May 24.

Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Off-label drugs use is widespread in ophthalmology due to the delay in drug approvals and package inserts update. It has been found to vary among different medical institutions in China, leading to safety problems since inappropriate use. Guidance is urgently needed regarding how best to use the drugs for unapproved indications and routes of administration. Read More

J Clin Med 2022 Jun 1;11(11). Epub 2022 Jun 1.

Department of Ophthalmology, University of Puerto Rico School of Medicine, Medical Sciences Campus, San Juan, PR 00936, USA.

Endophthalmitis treatment consists of intravitreal antibiotics injections and, in selected circumstances, pars plana vitrectomy. However, severe or refractory cases may require an enucleation or evisceration (ENEV). Our study seeks to identify risk factors leading to enucleation or evisceration in patients with infectious endophthalmitis. Read More

Ophthalmol Retina 2022 Jun;6(6):439-441

Philadelphia, Pennsylvania. Electronic address:

Graefes Arch Clin Exp Ophthalmol 2022 Jun 9. Epub 2022 Jun 9.

Farabi Eye Hospital, Tehran University of Medical Sciences, South Karegar Street, Tehran, Iran.

Purpose: To evaluate the role of patient facial masks on the occurrence of post-intravitreal injection (IVI) endophthalmitis in a real-word setting.

Methods: In this retrospective cohort, patients receiving IVIs between 20 February 2019 and 20 February 2021; a 12-month period before the official beginning of COVID-19 epidemic in Iran and a 12-month period thereafter were included. In the pre-COVID era, patients underwent IVI without a facial mask while in the COVID era patients wore an untaped facial mask. Read More

Cochrane Database Syst Rev 2022 06 6;6:CD012131. Epub 2022 Jun 6.

Stein Eye Institute, UCLA, Los Angeles, California, USA.

Background: Endophthalmitis refers to severe infection within the eye that involves the aqueous humor or vitreous humor, or both, and that threatens vision. Most cases of endophthalmitis are exogenous (i.e. Read More

Cureus 2022 May 1;14(5):e24636. Epub 2022 May 1.

Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS.

Ocular injury related to cat bites is rare, and no proper guidelines have been suggested for the treatment of such injuries. We report a rare case of zone II penetrating ocular injury secondary to a cat bite. A 49-year-old lady presented with left eye pain following a cat bite over the left eye, which occurred four hours prior to the presentation. Read More

IDCases 2022 20;29:e01516. Epub 2022 May 20.

Department of Infectious Disease, University Medical Center, 1800 W Charleston Blvd, Las Vegas, NV 89102, United States.

Background: The species is a gram positive, anaerobic, rod-shaped microbe that is known to produce many toxins. Most infections by the species involve , , and . However, other types of species are also clinically relevant, such as and . Read More

Am J Ophthalmol 2022 May 31. Epub 2022 May 31.

Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington, United States of America. Electronic address:

Purpose: To evaluate the utility of nanopore sequencing for identification of potential causative pathogens in endophthalmitis, comparing culture results against full-length 16S rRNA nanopore sequencing (16S Nanopore), whole genome nanopore sequencing (Nanopore WGS) and Illumina (Illumina WGS) DESIGN: : Cross-sectional diagnostic comparison METHODS: : Patients with clinically suspected endophthalmitis underwent intraocular vitreous biopsy as per standard-care. Clinical samples were cultured by conventional methods, together with full length 16S rRNA and WGS using nanopore and Illumina sequencing platforms.

Results: Of twenty-three patients (median age 68. Read More

J Glaucoma 2022 Jun 2. Epub 2022 Jun 2.

The Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Palm Beach Gardens, FL.

Prcis: Bleb-related endophthalmitis is a serious complication of glaucoma filtration surgery. The current study reports similar visual and intraocular pressure outcomes in eyes treated with pars plana vitrectomy compared to vitreous biopsy and intravitreal antibiotics.

Purpose: To investigate the isolated organisms, visual acuity (VA) and intraocular pressure (IOP) outcomes associated with delayed-onset bleb-related endophthalmitis (BRE) in eyes treated with pars plana vitrectomy (PPV) versus vitreous biopsy and injection of intravitreal antibiotics (TI). Read More

J Glaucoma 2022 Jun 7;31(6):e37-e40. Epub 2022 Apr 7.

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN.

Postoperative endophthalmitis caused by Rothia mucilaginosa, a gram-positive, coagulase-negative Micrococcaceae of the oropharyngeal flora, is rare and all previously reported intraocular implant-related cases have resulted in evisceration. R. mucilaginosa endophthalmitis has also not been described with any glaucoma implant device. Read More

Indian J Ophthalmol 2022 Jun;70(6):2084-2089

Department of Ophthalmology, Advanced Eye Centre, Chandigarh, India.

Purpose: To report clinical features, antibiotic susceptibility profile, management, and outcomes of a cluster outbreak of post-cataract surgery Pseudomonas stutzeri endophthalmitis.

Methods: This was a hospital-based case series in which 14 patients with acute postoperative endophthalmitis who underwent cataract surgery on the same day were included. Based on severity of presentation, they either underwent pars plana vitrectomy (PPV) with intraocular antibiotics (IOAB) or vitreous tap with IOAB. Read More

J Prev Med Hyg 2022 Mar 26;63(1):E139-E141. Epub 2022 Apr 26.

Department of Health Sciences, University of Milan, Milan, Italy.

Endophthalmitis due to Listeria monocytogenes is a rare form of listeriosis. Here, we report two cases that occurred in patients with different medical history, a 46-years-old woman with no comorbidities and an elderly man with several comorbidities. There was no history of trauma or surgery in either patient suggesting an endogenous origin. Read More

Dis Mon 2022 May 26:101393. Epub 2022 May 26.

Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS USA. Electronic address:

Rev Argent Microbiol 2022 May 25. Epub 2022 May 25.

Servicio de Microbiología, Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan" Ciudad Autónoma de Buenos Aires, Argentina.

Scedosporium/Lomentospora species are widely distributed in nature. They are generally saprophytes, but can cause opportunistic infections in immunocompromised patients and occasionally in immunocompetent patients that are difficult to treat due to high levels of antifungal resistance. The distribution of Scedosporium/Lomentospora species shows regional differences. Read More

J Mycol Med 2022 May 22;32(4):101298. Epub 2022 May 22.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address:

Corynespora cassiicola is an environmental phytopathogen implicated in various human infections and has been isolated from one case of keratitis. We report here the first case of endophthalmitis caused by Corynespora cassiicola in a 54-year-old diabetic patient, who developed diminished vision, redness, and watering in the right eye, six weeks after intravitreal triamcinolone acetonide for non-proliferative diabetic retinopathy and macular oedema. Direct microscopy of the vitreous tap revealed septate hyphae, and culture grew white mycelium that turned olive-grey to black within two days and was confirmed as C. Read More