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J Pak Med Assoc 2021 Apr;71(4):1184-1188

Department of Ophthalmology, Shifa International Hospital, Islamabad, Pakistan.

Objective: To assess the rate of infectious endophthalmitis with anti-vascular endothelial growth factor injection, and to evaluate institutional procedure protocol in this regard.

Methods: The retrospective consecutive case series was conducted at Shifa International Hospital, Islamabad, Pakistan, from August 2018 to January 2019, and comprised 5-year data from August 2014 to July 2019 related to patients who underwent intravitreal anti-vascular endothelial growth factor injections. Data was analysed using SPSS 21. Read More

J Ophthalmic Inflamm Infect 2021 Jun 14;11(1):17. Epub 2021 Jun 14.

Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Purpose: To evaluate the factors associated with the development of ocular candidiasis (OC) and ocular prognosis with echinocandin therapy for candidemia.

Methods: The medical records of 56 consecutive patients with a positive blood culture for Candida species between November 2016 and October 2019 were retrospectively reviewed. Information on patient characteristics, isolated Candida species, treatment details for candidemia, and ocular findings were extracted to identify factors associated with OC development. Read More

Eur J Ophthalmol 2021 Jun 14:11206721211024809. Epub 2021 Jun 14.

Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bangalore, Karnataka, India.

Introduction: Treating chronic macular edema (CME) post endophthalmitis is a challenge. Use of steroids may reactivate the infection and repeated intravitreal therapy with anti-vascular growth factor inhibitors (Anti-VEGF) puts the patient again at the risk of exacerbation of inflammation or endophthalmitis. We describe a case of CME post traumatic endophthalmitis successfully treated with topical interferon therapy. Read More

Korean J Ophthalmol 2021 Jun 4;35(3):251-253. Epub 2021 Jun 4.

St Erik Eye Hospital, Stockholm, Sweden.

Ocul Surf 2021 Jun 9;21:178-185. Epub 2021 Jun 9.

Department of Ophthalmology, Chinese PLA General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address:

Purpose: To evaluate long-term anatomical and functional outcomes of the MICOF keratoprosthesis to treat end-stage corneal blindness.

Design: Retrospective review of consecutive clinical case series.

Participants: Between October 2000 and October 2015, at the Department of Ophthalmology of Chinese PLA General Hospital (PLAGH), a total of 132 eyes of 131 patients had undergone a MICOF keratoprosthesis implantation. Read More

Int Ophthalmol 2021 Jun 10. Epub 2021 Jun 10.

University and Polytechnic Hospital of La Fé, Valencia, Spain.

Purpose: To describe and evaluate the main direct health costs, in routine clinical practice, of age-related macular degeneration (AMD) patients, from hospital perspective, in Spain.

Methods: Retrospective, multicenter, and observational study conducted on five third-level Spanish hospitals, between December 2018 and December 2019. The study included patients who were diagnosed of AMD before December 2018. Read More

Ann Palliat Med 2021 May;10(5):5619-5626

Shenzhen Eye Hospital, Shenzhen Eye Hospital affiliated to Jinan University, School of Optometry, Shenzhen University, Shenzhen, China.

Background: To evaluate the visual outcome and complications of surgical membranectomy with modified incision and capsulotomy microscissors in patients with persistent pupillary membrane (PPM).

Methods: We enrolled eight eyes with PPM in six patients and performed surgical membranectomy with modified incision located near the limbus and corresponding to the middle of the densest membrane strands. Strands near the collarette of the iris were then cut using capsulotomy microscissors and thick strands were removed with capculorhexis forceps. Read More

Am J Ophthalmol 2021 Jun 6. Epub 2021 Jun 6.

Department of Ophthalmology, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Purpose: To evaluate the incidence of vitreoretinal complications, treatment modalities, and the visual outcomes in a large cohort of eyes that underwent Boston Keratoprosthesis (KPro) implantation.

Design: Retrospective, interventional case series.

Methods: 132 eyes of 114 patients who underwent KPro implantation at the Centre Hospitalier de l'Université de Montréal from 2008 to 2017 were included with at least 1 year follow-up. Read More

Ophthalmology 2021 Jun 5. Epub 2021 Jun 5.

Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA. Electronic address:

The prevalence of endophthalmitis after minimally invasive glaucoma surgery (MIGS) in this large 5-year series was 0.13% [0.04% - 0. Read More

Am J Ophthalmol 2021 Jun 5. Epub 2021 Jun 5.

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University 2 Wanglang Road, Bangkok Noi, Bangkok 10700, Thailand.

Purpose: To evaluate the long-term outcomes, anatomical retention and complications of Boston type I keratoprosthesis (KPro).

Design: Retrospective, interventional case series.

Methods: A retrospective chart review of implantations performed January 2008-December 2017 was conducted. Read More

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):440-446

Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Tianjin 300384, China.

To report the efficacy and safety of minimally invasive vitrectomy for the treatment of severe proliferative diabetic retinopathy (PDR) and the effect of preoperative retinal photocoagulation on prognosis. Case-series study and cohort study. This study included 48 severe PDR patients (53 eyes). Read More

Infect Immun 2021 Jun 7:IAI0020121. Epub 2021 Jun 7.

Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Endophthalmitis is a devastating infection that can cause blindness. Over half of endophthalmitis cases result in significant loss of useful vision. produces many virulence factors that may contribute to retinal damage and robust inflammation. Read More

Cell Rep Med 2021 May 18;2(5):100277. Epub 2021 May 18.

Department of Ophthalmology, Visual and Anatomical Sciences, Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA.

The eye is highly susceptible to inflammation-mediated tissue damage evoked during bacterial infection. However, mechanisms regulating inflammation to protect the eye remain elusive. Here, we used integrated metabolomics and transcriptomics to show that the immunomodulatory metabolite itaconate and immune-responsive gene 1 () are induced in bacterial ()-infected mouse eyes, bone-marrow-derived macrophages (BMDMs), and Müller glia. Read More

Egypt Heart J 2021 Jun 6;73(1):52. Epub 2021 Jun 6.

Department of Anesthesia, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Ocular manifestations of infective endocarditis are nonspecific and rare. Endophthalmitis, retinal artery occlusion, Roth spots and vitreal and retinal infiltrations can all be seen with infective endocarditis. Also, infective endocarditis involving the left atrial appendage with no involvement of the mitral valve apparatus is a rarity. Read More

Ophthalmologe 2021 Jun 4. Epub 2021 Jun 4.

Commission for Cross-Sectoral Ophthalmology of the DOG (German Ophthalmological Society e. V.) and BVA (Professional Association of German Ophthalmologists), Munich/Düsseldorf, Germany.

Background: Survey by the commission for cross-sectoral ophthalmology, as a joint commission of the German Ophthalmological Society (DOG) and the Professional Association of German Ophthalmologists (BVA) on the effects of the SARS-CoV‑2 pandemic on ophthalmological patient care in Germany.

Methods: Online-based survey.

Results: A total of 1190 questionnaires were (partly) answered. Read More

Cureus 2021 Apr 28;13(4):e14745. Epub 2021 Apr 28.

Internal Medicine, Florida State University College of Medicine Internal Medicine Residency Program, Sarasota, USA.

Endogenous endophthalmitis (EE) is a potentially blinding ophthalmological emergency with poor visual prognosis requiring a high index of clinical suspicion to obtain a prompt diagnosis. The main factors associated with poor visual outcomes include the virulence of the causative organism and timing of intervention. Infective endocarditis can present with nonspecific ocular complaints and remains an important risk factor for developing EE. Read More

Oman J Ophthalmol 2021 Jan-Apr;14(1):52-55. Epub 2021 Feb 27.

Glaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA.

The purpose of this study was to report a case of neovascularization of angle (NVA) following trabeculectomy with mitomycin-c (MMC) in a patient with primary open-angle glaucoma. This case report describes a 68-year-old woman who developed NVA and hyphema 2 weeks following an uneventful trabeculectomy with MMC. Trabeculectomy may be associated with serious and vision-threatening complications such as hypotony, suprachoroidal hemorrhage, endophthalmitis, and bleb-related complications. Read More

Oman J Ophthalmol 2021 Jan-Apr;14(1):20-26. Epub 2021 Feb 27.

Jasti V Ramanamma, Children's Eye Care Center, L V Prasad Eye Institute, Hyderabad, India.

Aim: To evaluate the postoperative visual acuity and complications in eyes with ectopia lentis in children who underwent lens removal and then implantation of retropupillary fixated iris claw lens versus scleral fixated intraocular lens (SFIOL) implantation.

Materials And Methods: A retrospective analysis of pediatric cases who presented with lens subluxation secondary to ectopia lentis and who underwent lens extraction (57 eyes of 38 patients) with either retropupillary iris fixated intraocular lens (IOL) implantation (Group A - 36 eyes of 20 patients) and SFIOL implantation (Group B - 21 eyes of 18 patients) was done over a period of 5 years from March 2010 to February 2015. The main outcome measures were preoperative and postoperative best-corrected visual acuity (BCVA) and secondary postoperative complications. Read More

Vet Ophthalmol 2021 Jun 2. Epub 2021 Jun 2.

Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.

A 10-year-old Boer goat wether presented for unilateral exophthalmos of 2- to 3-week duration. Ocular ultrasonography and computed tomography (CT) were utilized in the diagnosis of the patient's orbital disease and surgical planning. Exenteration was performed under the same general anesthetic event as CT. Read More

Cureus 2021 Apr 13;13(4):e14464. Epub 2021 Apr 13.

Ophthalmology, Hygeia Clinic, Gdansk, POL.

Infectious endophthalmitis is the most devastating complication of eye surgery and is associated with severe inflammation of ocular tissues. This study aimed to present a similar condition, a case of toxic anterior segment syndrome (TASS) after an uncomplicated vitrectomy. A 69-year-old woman presented with epiretinal membrane and underwent 25-gauge pars plana vitrectomy with membrane peeling in her left eye. Read More

Clin Microbiol Rev 2021 Jun 2;34(3):e0007019. Epub 2021 Jun 2.

Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

The variety and complexity of ocular infections have increased significantly in the last decade since the publication of , (L. D. Gray, P. Read More

Eur J Ophthalmol 2021 Jun 2:11206721211021185. Epub 2021 Jun 2.

Retina Specialists of Alabama, Birmingham, AL, USA.

We recently co-authored a report on the ten-year (2007-2017) results achieved at our center (Retina Specialists of Alabama) in the treatment of Acute Post-Cataract Endophthalmitis (APCE). Of all eyes, 77.4% were initially treated with Complete and Early Vitrectomy for Endophthalmitis (CEVE). Read More

J Clin Med 2021 May 19;10(10). Epub 2021 May 19.

Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.

A multicenter, nonrandomized, prospective, controlled study was conducted to evaluate, as perioperative prophylactic treatment, the anti-infective effectiveness of 0.66% povidone-iodine eye drops (IODIM) against the bacterial flora of the conjunctival surface of patients who undergo cataract surgery. Eye drops containing 0. Read More

Microorganisms 2021 May 22;9(6). Epub 2021 May 22.

Jhaveri Microbiology Centre, Prof. Brien Holden Eye Research Centre, Kallam Anji Reddy Campus, L. V. Prasad Eye Institute, Hyderabad 500034, Telangana, India.

The biofilm-forming potential of and , isolated from patients with Endophthalmitis, was monitored using glass cover slips and cadaveric corneas as substrata. Both the ocular fluid isolates exhibited biofilm-forming potential by the Congo red agar, Crystal violet and 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-(phenylamino) carbonyl-2H-tetra-zolium hydroxide (XTT) methods. Confocal microscopy demonstrated that the thickness of the biofilm increased from 4-120 h of biofilm formation. Read More

J Ophthalmic Inflamm Infect 2021 Jun 1;11(1):16. Epub 2021 Jun 1.

Department of Ophthalmology, Charles University, 2nd Faculty of Medicine and University Hospital in Motol, Prague, Czech Republic.

A case report of post-traumatic exogenous endophthalmitis caused by Nocardia farcinica, including treatment procedures, microbiology examination, and systemic medications. A 23-year-old male suffered a penetrating corneal injury that was treated with sutures. On the thirteenth day after the final suture was removed, an anterior uveitis developed and progressed to whitish, plump, nodular, and tufted exudates within the anterior chamber over the next 10 days; this led to an indication for intraocular surgery. Read More

Can J Ophthalmol 2021 May 28. Epub 2021 May 28.

Department of Ophthalmology, University of Montreal Hospital Centre, Montreal, Que.

Objective: To compare the rate of long-term complications in Boston keratoprosthesis type 1 (KPro) patients with and without soft contact lens wear (SCL).

Methods: A chart review was performed on patients who underwent KPro type 1 surgery from January 2008 to June 2018 performed by a single surgeon at the University of Montreal Hospital Centre. Ninety-nine KPro patients (114 eyes) were separated into group 1 (patients with SCL) and group 2 (patients without SCL) at 1 and 5 years. Read More

Can J Ophthalmol 2021 May 29. Epub 2021 May 29.

Dept of Ophthalmology, University of Manitoba, Winnipeg, Man.

Objective: To evaluate the safety of performing cataract surgery prior to eyelid (entropion/ectropion) surgery in patients with concurrent cataract and lower eyelid malposition.

Design: Retrospective case series.

Participants And Methods: Patients with concurrent lower eyelid malposition and cataract undergoing cataract surgery before lower eyelid repair from 2013 to 2020 were identified from two ophthalmologists (M. Read More

Jpn J Ophthalmol 2021 May 31. Epub 2021 May 31.

Department of Otorhinolaryngology-Head and Neck Surgery, Kayseri City Training and Research Hospital, University of Health Science, Kayseri, Turkey.

Purpose: To present the different clinical manifestations of rhino-orbital mucormycosis (ROM) co-infection in severe COVID-19 patients.

Study Design: Prospective observational clinical study METHODS: Among 32,814 patients hospitalized with the diagnosis of COVID-19 between March 2020 and December 2020 in our center, eleven microbiologically confirmed ROM co-infection cases in severe COVID-19 patients were evaluated.

Results: There were nine men and two women with a mean age of 73. Read More

Case Rep Ophthalmol Med 2020 2;2020:8824585. Epub 2020 Dec 2.

Center for Ophthalmology, Eberhard Karl University, Tuebingen, Germany.

Sterility is an important prerequisite for minimizing the risk of severe vision loss due to endophthalmitis after intravitreal injections. We describe three cases series of incidents where an unclear contamination of the drug solution or syringe caused the injection process to stop and continue with a new preparation. During a period of 12 months with 30,502 intravitreal injections at a tertiary center, wherein 7,076 were of the drug Aflibercept drawn up from a glass vial, three cases of the critical incident reporting system relating to intravitreal injections were identified: (1) After a typical contact with the filter cannula, the glass of an Aflibercept vial was no longer intact. Read More

Case Rep Ophthalmol 2021 May-Aug;12(2):418-424. Epub 2021 May 11.

Department of Ophthalmology, Sultan Qaboos University Hospital, Al Khoudh, Oman.

We experienced an atypical endophthalmitis occurring post consecutively performed in-office procedures; an intravitreal injection (IVI) of ranibizumab followed by an anterior chamber (AC) paracentesis performed twice in an eye with neovascular glaucoma (NVG). A 52-year-old diabetic male who was asymptomatic developed signs of endophthalmitis and decreased vision without pain in his left eye a few days post-IVI and AC paracentesis. The condition worsened after an initial vitreous tap and injection of antibiotics. Read More