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ESC Heart Fail 2022 Jun 23. Epub 2022 Jun 23.

Department of Diagnostic Pathology, Nara Medical University, 840 Shijo, Kashihara, Nara, 643-8522, Japan.

Aims: Cancer therapy-related cardiac dysfunction (CTRCD) is commonly reported, but its histopathology, mechanisms, and risk factors are not known. We aimed to clarify the histopathology and mechanisms of CTRCD to identify risk factors.

Methods And Results: We performed myocardial histopathological studies on 13 endomyocardial biopsies from CTRCD patients, 35 autopsied cancer cases with or without cardiac dysfunction, and controls without cancer (10 biopsies and 9 autopsies). Read More

Diagnostics (Basel) 2022 Jun 1;12(6). Epub 2022 Jun 1.

Division of Cardiology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, Korea.

Heart failure (HF) is a clinical syndrome caused by various etiologies that results in systolic and diastolic cardiac dysfunction with congestion. While evaluating HF and planning for treatment, physicians utilize various laboratory tests, including electrocardiography, diverse imaging tests, exercise testing, invasive hemodynamic evaluation, or endomyocardial biopsy. Among these, cardiac imaging modalities and biomarkers are the mainstays during HF diagnosis and treatment. Read More

Eur Heart J Case Rep 2022 Jun 23;6(6):ytac179. Epub 2022 Apr 23.

Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

Background: Management of pulmonary hypertension (PH) in the setting of heart failure with preserved ejection fraction (HFpEF) can be challenging. Herein, we describe the case of a patient with HFpEF and combined pre- and post-capillary PH who showed striking improvement with sildenafil.

Case Summary: A 74-year-old man presented with exertional dyspnea and near-syncope. Read More

Int J Cardiol 2022 Sep 31;362:110-117. Epub 2022 May 31.

Department of Cardiology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.

Background: The impact of quantitative pathological findings derived from endomyocardial biopsies (EMB) on clinical prognosis in patients with hypertrophic cardiomyopathy (HCM) remains unclear.

Methods: We retrospectively studied 55 consecutive HCM patients who underwent EMB. We quantified the collagen area fraction (CAF), the cardiomyocyte diameter, the nuclear area and circularity, and the number of myocardial infiltrating CD3 cells using EMB samples by image analyzing software. Read More

J Mol Cell Cardiol 2022 Jun 1;169:111-112. Epub 2022 Jun 1.

Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, 12700 E. 19th Ave, Aurora, CO 80045-0508, USA. Electronic address:

J Tehran Heart Cent 2021 Jul;16(3):109-112

Clinical Research Development Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran.

: Behcet's disease (BD) is a vasculitis with multisystem and multiorgan involvement. Cardiac involvement in BD is a rare complication with a poor outcome that manifests itself in different forms. In this study, we aimed to investigate cardiac involvement in BD. Read More

Clin Case Rep 2022 May 23;10(5):e05021. Epub 2022 May 23.

Department of Cardiology Heart Hospital HMC Doha Qatar.

Endomyocardial fibrosis (EMF) is a disease known to cause restrictive cardiomyopathy. It shows a high prevalence in tropical countries. Several triggering factors have been proposed. Read More

Neurol Sci 2022 May 19. Epub 2022 May 19.

Department of Neurology, University Hospital, RTWH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.

Introduction: Ischemic stroke is a potential complication of hypereosinophilic syndromes (HES), and little is known about underlying pathophysiological mechanisms. We aimed to describe the imaging patterns of cerebral ischemia in patients with HES.

Methods: An individual case is reported. Read More

Cardiol Young 2022 May 16:1-3. Epub 2022 May 16.

Department of Pediatrics, PSG Institute of Medical Sciences and Research, Peelamedu, Coimbatore 641004, Tamil Nadu, India.

Eosinophilic granulomatosis polyangiitis represents less than 2% of vasculitis cases in childhood. Children have worse long-term outcomes and higher mortality. Cardiac involvement portends a worse prognosis. Read More

J Biomed Opt 2022 May;27(5)

Indian Institute of Science, Department of Electronic Systems Engineering, Bangalore, Karnataka, India.

Significance: Optical polarimetry is an emerging modality that effectively quantifies the bulk optical properties that correlate with the anisotropic structural properties of cardiac tissues. We demonstrate the application of a polarimetric tool for characterizing healthy and fibrotic human myocardial tissues efficiently with a high degree of accuracy.

Aim: The study was aimed to characterize the myocardial tissues from the left ventricle and right ventricle of N  =  7 control and N  =  10 diseased subjects. Read More

Ann Pediatr Cardiol 2021 Oct-Dec;14(4):516-520. Epub 2022 Mar 25.

Department of Pediatric Cardiology, Madras Medical Mission, Institute of Cardio Vascular Diseases, Chennai, Tamil Nadu, India.

A 32-year-old male with symptomatic polycythemia was investigated by hematologist for myeloproliferative malignancies and underwent five therapeutic phlebotomies. The identification of hypoxia on pulse oximetry later led to pulmonology evaluation that showed normal lung function tests as well as normal lung parenchyma and airways on advanced imaging. The absence of murmurs and significant precordial findings, normal chest X-ray, and unremarkable findings in electrocardiogram apart from first-degree heart block delayed the cardiac referral. Read More

Rev Esp Cardiol (Engl Ed) 2022 May 3. Epub 2022 May 3.

Centre Médical Christ-Roi d'Obout, Obout, Cameroon.

Front Cardiovasc Med 2022 15;9:841346. Epub 2022 Apr 15.

Uganda Heart Institute, Mulago Hospital Complex, Kampala, Uganda.

Background: First described in Uganda over seven decades ago, Endomyocardial fibrosis (EMF) is a rare form of restrictive cardiomyopathy found in the tropics. EMF occurs mainly in two phenotypes; biventricular involvement and right ventricular (RV) form. Previously endemic in several countries, there are reports suggesting that the disease is on the decline. Read More

Eur Heart J Case Rep 2022 Mar 21;6(3):ytac105. Epub 2022 Mar 21.

Division of Cardiology, Bluhm Cardiovascular Institute, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Standardized diagnostic criteria for arrhythmogenic left ventricular cardiomyopathy (ALVC) have been recently proposed. The criteria emphasize structural left ventricle (LV) myocardial change on contrast-enhanced imaging and require the identification of gene variants associated with arrhythmogenic cardiomyopathy.

Case Summary: A 21-year-old man presented for evaluation of exertional syncope and was found to have monomorphic ventricular tachycardia (VT) and an episode of polymorphic VT that degenerated to ventricular fibrillatory cardiac arrest. Read More

BMJ Case Rep 2022 Apr 21;15(4). Epub 2022 Apr 21.

Department of Cardiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.

We present the case of a woman with a 2-month history of exertional dyspnoea and fatigue in which echocardiography revealed a cavity-obliterating right ventricular mass. Further imaging evaluation using cardiac magnetic resonance showed a thrombotic mass as well as diffuse myocardial oedema and endomyocardial fibrosis (EMF) that involved both ventricles. In the absence of any other cause (including peripheral eosinophilia), the diagnosis of idiopathic EMF was established. Read More

J Imaging 2022 Apr 5;8(4). Epub 2022 Apr 5.

Cardiology Unit, Madre Giuseppina Vannini Hospital, 00177 Rome, Italy.

Immune checkpoint inhibitors (ICIs) are a family of anticancer drugs in which the immune response elicited against the tumor may involve other organs, including the heart. Cardiac magnetic resonance (CMR) imaging is increasingly used in the diagnostic work-up of myocardial inflammation; recently, several studies investigated the use of CMR in patients with ICI-myocarditis (ICI-M). The aim of the present systematic review is to summarize the available evidence on CMR findings in ICI-M. Read More

Methodist Debakey Cardiovasc J 2022 14;18(2):4-16. Epub 2022 Mar 14.

Department of Cardiovascular Medicine, Houston Methodist Hospital, Houston, Texas, US.

Restrictive cardiomyopathy (RCM) includes a heterogeneous group of diseases that cause increased myocardial stiffness, leading to impaired ventricular relaxation and severe diastolic dysfunction. Given that it is the least common type of cardiomyopathy, it can be a diagnostic challenge due to its varied pathogenesis, clinical presentation, and diagnostic evaluation. In this review, we provide an overview of different etiologies of RCM and examine the diagnostic and treatment approaches for various types. Read More

J Healthc Eng 2022 23;2022:2808889. Epub 2022 Mar 23.

School of Nursing, Tongji Medical College Huazhong University of Science and Technology, Wuhan 430000, China.

The heart is one of the most important organs of the human body, but in recent years heart disease has become one of the human health killers and this paper explores endomyocardial fibrosis, which is a common cardiomyopathy, commonly seen in infants and children, and refers to a diffuse elastic fibrous disease of the endocardium. The purpose of this paper is to explore the diagnostic imaging analysis and care of patients with endocardial heart machine fibrosis using wireless network intelligent medical technology, aiming to provide a new power basis for the treatment of the disease in related patients. This paper proposes a new endocardial segmentation algorithm that aims to process image information using image features, intervene in image noise reduction and smoothing, etc. Read More

Eur Heart J Case Rep 2022 Feb 10;6(2):ytac066. Epub 2022 Feb 10.

Division of Cardiology, Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

Eur J Case Rep Intern Med 2022 23;9(2):003026. Epub 2022 Feb 23.

Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA.

Coronavirus disease (COVID-19) has infected millions of people worldwide. Its cardiac presentations include myocarditis, arrhythmias and structural heart changes even in young and healthy individuals. The long-term sequelae of these manifestations are unknown. Read More

J Cardiol 2022 Mar 1. Epub 2022 Mar 1.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 5148507, Japan.

Alteration in myocardial tissue, such as myocardial fibrosis, edema, inflammation, or accumulation with amyloid, lipids, or iron, has an important role in the cardiac remodeling that leads to diastolic and/or systolic dysfunction and the development of chronic heart failure, increasing the risk of adverse cardiovascular events. Thus, the early detection of changes at myocardial tissue level has great diagnostic and prognostic potential. The gold standard technique to assess these myocardial alterations is endomyocardial biopsy. Read More

Arq Bras Cardiol 2022 01;118(1):103-105

Hospital de Clínicas de Porto Alegre - Serviço de Cardiologia, Porto Alegre, RS - Brasil.

Ann Cardiol Angeiol (Paris) 2022 Apr 17;71(2):63-74. Epub 2022 Feb 17.

CHU Henri Mondor, 1 Rue Gustave Eiffel, 94000 Créteil. Electronic address:

Infiltrative cardiomyopathies are abnormal accumulations or depositions of different substances in cardiac tissue leading to its dysfunction, first diastolic, then systolic. The different infiltrative cardiomyopathies are amyloidosis (both light chain amyloidosis and transthyretin amyloidosis variants), lysosomal and glycogen storage disorders (Fabry-Anderson disease), and iron overload (hemochromatosis and thalassemia associated with blood transfusions), as well as inflammatory diseases such as sarcoidosis. We also evoke hypereosinophilic syndrome associated with endomyocardial fibrosis. Read More

Cells 2022 01 25;11(3). Epub 2022 Jan 25.

Department of Cardiology, Heart Center Leipzig at the University of Leipzig, Strümpellstraße 39, 04289 Leipzig, Germany.

Introduction: Inflammatory cardiomyopathy (ICM) frequently leads to myocardial fibrosis, resulting in permanent deterioration of the left ventricular function and an unfavorable outcome. Soluble suppression of tumorigenicity 2 receptor (sST2) is a novel marker of inflammation and fibrosis in cardiovascular tissues. sST2 was found to be helpful in predicting adverse outcomes in heart failure patients with reduced ejection fraction. Read More

Pan Afr Med J 2022 4;41. Epub 2022 Jan 4.

Department of Cardiology, Military Hospital Avicenne, University Cadi Ayyad, Marrakech, Morocco.

Tropical endomyocardial fibrosis (TEF) is a rare condition that occurs primarily in tropical countries, leading to a severe heart failure with heart restrictive filling patterns. Eosinophilia appears to be a trigger leading to the development of the disease; thus, numerous etiologic factors accompanied by eosinophilia have been postulated, although none have been confirmed. The massively calcified form of TEF is exceptional and easily diagnosed by multimodal imaging; but it is a very rare condition with high surgical challenge. Read More

Acta Naturae 2021 Oct-Dec;13(4):42-46

Shumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow, 123182 Russia.

The transforming growth factor β1 (TGFβ1), whose level may depend on the polymorphism of the TGFB1 gene, is involved in the formation of myocardial fibrosis. Myocardial fibrosis in a cardiac allograft may lead to a heart's structural and functional remodeling and subsequent dysfunction. The frequency of occurrence of alleles and genotypes of the TGFB1 gene polymorphic regions rs1800469, rs1800470, and rs1800471 in heart transplant recipients and their association with graft myocardial fibrosis were analyzed. Read More

ESC Heart Fail 2022 04 2;9(2):1304-1313. Epub 2022 Feb 2.

Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Aims: Autotaxin (ATX) promotes myocardial inflammation, fibrosis, and the subsequent cardiac remodelling through lysophosphatidic acid production. However, the prognostic impact of serum ATX in non-ischaemic dilated cardiomyopathy (NIDCM) has not been clarified. We investigated the prognostic impact of serum ATX in patients with NIDCM. Read More

Case Rep Oncol 2021 Sep-Dec;14(3):1853-1859. Epub 2021 Dec 30.

Department of Internal Medicine, Vanderbilt University, Nashville, Tennessee, USA.

Bortezomib (BTZ) is a proteasome inhibitor used in the treatment of multiple myeloma (MM) and other hematological malignancies. Although carfilzomib, a second-generation proteasome inhibitor, is most strongly associated with cardiotoxicity, BTZ has been associated with several cardiovascular complications including congestive heart failure, arrhythmias, and rarely myocarditis. Here, we report the first case of a BTZ-induced perimyocarditis. Read More

J Cardiol Cases 2022 Feb 31;25(2):95-98. Epub 2021 Jul 31.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki ho, Chuo-ku, Kobe 6500017, Japan.

Eosinophilic myocarditis (EM) is an under-diagnosed inflammatory heart disease that often leads to severe left ventricular (LV) dysfunction. Meanwhile, severe secondary mitral regurgitation (MR) with valve disruption, possibly requiring mitral valve repair, is rarely concomitant with EM. We present the case of a 64-year-old female diagnosed with heart failure with severe LV dysfunction and localized asynergy. Read More

J Cardiol Cases 2021 Oct 7;24(4):157-160. Epub 2021 Apr 7.

Division of Cardiology, San Jacopo Hospital, Pistoia, Italy.

Behçet disease (BD) is a form of widespread vasculitis that involves both arteries and veins. Cardiac involvement in BD is exceedingly rare and can present as a form of non-bacterial- thrombotic-endocarditis (NBTE). A 54-year-old man with Behçet disease was admitted to our hospital after presenting with abdominal pain and fever. Read More