2,742 results match your criteria Endomyocardial Fibrosis


Recent Advances in Imaging of Hypertensive Heart Disease.

Curr Hypertens Rep 2019 Jan 14;21(1). Epub 2019 Jan 14.

Department of Cardiology, University of Virginia, Charlottesville, VA, USA.

Purpose Of Review: To review recent advances in the imaging of hypertensive heart disease (HHD) with an emphasis on developments in the imaging of diffuse myocardial fibrosis using cardiac magnetic resonance (CMR).

Recent Findings: HHD results from long-standing hypertension and is characterized by the development of left ventricular hypertrophy and diffuse interstitial fibrosis. Diffuse fibrosis traditionally required endomyocardial biopsy to diagnose, but recent developments using T1 mapping in CMR allow for noninvasive assessment. Read More

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http://dx.doi.org/10.1007/s11906-019-0910-6DOI Listing
January 2019

Lymph Vessel Proliferation on Cardiac Biopsy May Help in the Diagnosis of Cardiac Sarcoidosis.

J Am Heart Assoc 2019 Jan;8(2):e010967

5 Department of Cardiovascular Medicine Hokkaido University Graduate School of Medicine Hokkaido Japan.

Background The diagnosis of cardiac sarcoidosis ( CS ) is challenging because endomyocardial biopsy has only a 20% to 30% sensitivity rate for diagnosis and it presents with similar clinical features of idiopathic dilated cardiomyopathy ( DCM ). Lymphatic vessel proliferation in pulmonary sarcoidosis has been previously demonstrated. In this study, we compared endomyocardial biopsy samples obtained from patients with CS and DCM to determine whether lymph vessel counts using D2-40 immunostaining can be utilized as a complementary tool to distinguish CS from DCM . Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.010967
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http://dx.doi.org/10.1161/JAHA.118.010967DOI Listing
January 2019
1 Read

Cardiac arrest in Wilson's disease after curative liver transplantation: a life-threatening complication of myocardial copper excess?

ESC Heart Fail 2019 Jan 8. Epub 2019 Jan 8.

Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.

We report the case of a 38-year-old man who presented with cardiac arrest 1 year after curative liver transplantation for Wilson's disease. Clinical work-up proofed myocardial copper and iron accumulation using mass spectrometry, which led most likely to myocardial fibrosis as visualized by cardiovascular magnetic resonance (unprecedented delayed enhancement pattern) and endomyocardial biopsy. Consequently, cardiac arrest due to ventricular fibrillation and subsequent episodes of sustained ventricular tachycardia were considered as primary cardiac manifestation of Wilson's disease. Read More

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http://dx.doi.org/10.1002/ehf2.12395DOI Listing
January 2019

Complex right atrial mass in endomyocardial fibrosis: a diagnostic dilemma.

BMJ Case Rep 2019 Jan 4;12(1). Epub 2019 Jan 4.

Cardiovascular radiology and endovascular interventions, All India Institute of Medical Sciences, New Delhi, India.

Endomyocardial fibrosis, though a vanishing disease from India, remains an important cause of heart failure in children, adolescents and young adults. It may be complicated with arrhythmias and thromboembolism and is an important cause of mortality and morbidity. Moreover, usual presentation of this condition is in advanced stage with poor prognosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-227131DOI Listing
January 2019

Impact of systemic immune-mediated diseases on clinical features and prognosis of patients with biopsy-proved myocarditis.

Int J Cardiol 2018 Nov 22. Epub 2018 Nov 22.

Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Hospital and University, Milan, Italy.

Introduction: Myocarditis has been described in association with many systemic immune-mediated diseases (SIDs). However, the role of SIDs in influencing clinical presentation and outcome of patients with a new diagnosis of biopsy-proved myocarditis, has never been investigated so far.

Methods: We enrolled 25 consecutive cases with biopsy-proved myocarditis in the context of SIDs, and controls with isolated myocarditis, matched 1:1 by age, gender, ethnicity and clinical presentation. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.11.104DOI Listing
November 2018
1 Read

Old-Age Onset Progressive Cardiac Contractile Dysfunction in a Patient with Polycystic Kidney Disease Harboring a PKD1 Frameshift Mutation.

Int Heart J 2018 Nov 20. Epub 2018 Nov 20.

Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.

A 70-year-old man with dyspnea was admitted to our department and received standard therapy for recurrent heart failure. He was diagnosed with polycystic kidney disease (PKD) in his thirties and received hemodialysis for 4 years before undergoing renal transplantation at age 45. Although his left ventricular ejection fraction (LVEF) was preserved in his 50s, LVEF decreased progressively from 61% to 24%, while left ventricular diastolic dimension (LVDd) increased from 54 mm to 65 mm between 63 and 69 years of age. Read More

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http://dx.doi.org/10.1536/ihj.18-184DOI Listing
November 2018
12 Reads

Role of Advanced Testing: Invasive Hemodynamics, Endomyocardial Biopsy, and Cardiopulmonary Exercise Testing.

Cardiol Clin 2019 Feb 29;37(1):73-82. Epub 2018 Oct 29.

Hypertrophic Cardiomyopathy Program, Cardiac Catheterization Laboratory, Westchester Medical Center, New York Medical College, 100 Woods Road, Macy Pavilion Room 106, Valhalla, NY 10595, USA.

Hypertrophic cardiomyopathy affects 0.5% of the population. Advanced testing is considered, including cardiac catheterization, endomyocardial biopsy, and cardiopulmonary exercise testing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338651183086
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http://dx.doi.org/10.1016/j.ccl.2018.08.010DOI Listing
February 2019
5 Reads
1.064 Impact Factor

Endomyocardial fibrosis and myocardial infarction leading to diastolic and systolic dysfunction requiring transplantation.

Cardiovasc Pathol 2019 Jan - Feb;38:21-24. Epub 2018 Oct 31.

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy. Electronic address:

Endomyocardial fibrosis (EMF) is an endemic disease in tropical areas, characterized by restrictive physiology due to endocardial fibrous thickening of the ventricular chambers. We report the case of a 25-year-old man of African origin who presented with end-stage heart failure due to both diastolic and systolic dysfunction and extensive endocavitary thrombosis as proven by echocardiography and cardiac magnetic resonance. EMF diagnosis was confirmed by endomyocardial biopsy and the patient had eventually cardiac transplantation. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.10.010DOI Listing
October 2018
1 Read

Analysis of the Correlation between the Myocardial Expression of DPP-4 and the Clinical Parameters of Patients with Heart Failure.

Int Heart J 2018 Nov 25;59(6):1303-1311. Epub 2018 Oct 25.

Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine.

Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used as antidiabetic drugs. We recently reported that DPP-4 inhibition has beneficial effects on heart failure (HF) mice model. Furthermore, we confirmed that myocardial DPP-4 activity was significantly increased in HF mice compared with non-HF mice. Read More

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http://dx.doi.org/10.1536/ihj.17-547DOI Listing
November 2018
1 Read

Myocardial Fibrosis Predicts 10-Year Survival in Patients Undergoing Aortic Valve Replacement.

Circ Cardiovasc Imaging 2018 Aug;11(8):e007131

Department of Internal Medicine I, Center of Cardiovascular Diseases, University Hospital, Universitätsklinikum Würzburg, Würzburg, Bayern, Germany (S.H., B.F., T.S., D.L., K.H., D.G., M.C., S.S., W.V., S.F., G.E., P.N.).

Background Long-term data on evolution and clinical impact of myocardial fibrosis in valvular heart disease are scarce. Methods and Results In this 10 years' extension of a prospective study in patients undergoing conventional aortic valve replacement because of symptomatic severe aortic valve stenosis, the impact of myocardial replacement fibrosis (MRF) on long-term outcome was assessed. Endomyocardial biopsies were acquired during aortic valve replacement in 58 consecutive patients. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.117.0071
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http://dx.doi.org/10.1161/CIRCIMAGING.117.007131DOI Listing
August 2018
10 Reads

Endomyocardial fibrosis and unileaflet mitral valve: a fatal postpartum outcome.

Eur Heart J 2018 Dec;39(48):4291

Clinic for Cardiology, Clinical Center of Serbia, Koste Todorovica 8, Belgrade, Serbia.

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http://dx.doi.org/10.1093/eurheartj/ehy672DOI Listing
December 2018

Plasma markers of myocardial inflammation at isolated atrial fibrillation.

J Arrhythm 2018 Oct 26;34(5):493-500. Epub 2018 Jun 26.

Cardiology Research Institute Tomsk National Research Medical Center Russian Academy of Science Tomsk Russia.

Background: Atrial fibrillation (AF) is one of the widest spread forms of arrhythmia, which is associated with the increased mortality and thromboembolic complications. To date, the involvement of renin-angiotensin-aldosterone system and immunomediators of inflammation into the mechanisms of development and maintenance of isolated AF is not clear. Specificity of their changes with respect to the latent myocarditis at AF is not proved. Read More

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http://doi.wiley.com/10.1002/joa3.12083
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http://dx.doi.org/10.1002/joa3.12083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174480PMC
October 2018
10 Reads

Endomyocardial Fibrosis: Cardiac Involvement in an HIV-infected Patient.

Rev Esp Cardiol (Engl Ed) 2018 Oct 11. Epub 2018 Oct 11.

Servicio de Radiología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain.

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http://dx.doi.org/10.1016/j.rec.2018.07.019DOI Listing
October 2018
1 Read

Assessment of myocardial fibrosis using T1-mapping and extracellular volume measurement on cardiac magnetic resonance imaging for the diagnosis of radiation-induced cardiomyopathy.

J Cardiol Cases 2018 Oct 30;18(4):132-135. Epub 2018 Jun 30.

Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.

Radiation-induced heart disease (RIHD) is a serious side effect of thoracic radiation therapy (RT) and is associated with significant morbidity and mortality. Radiation-induced cardiomyopathy (RICM) is one of the manifestations of RIHD, which represents with left ventricular (LV) systolic and diastolic dysfunction due to myocardial fibrosis. Although the diagnosis of RIHD is challenging and is generally an exclusion diagnosis, multimodality imaging including echocardiography, cardiac computed tomography and cardiac magnetic resonance (CMR) imaging could help the diagnosis. Read More

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http://dx.doi.org/10.1016/j.jccase.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149610PMC
October 2018
1 Read

Circulating markers of collagen types I, III, and IV in patients with dilated cardiomyopathy: relationships with myocardial collagen expression.

ESC Heart Fail 2018 12 1;5(6):1044-1051. Epub 2018 Oct 1.

Department of Cardiovascular Center, Osaka Red Cross Hospital, Osaka, Japan.

Aims: Collagen-derived peptides such as collagen I C-terminal telopeptide (CITP) and procollagen III N-terminal propeptide (PIIINP) have been conventionally used as markers of cardiac fibrosis. Collagen IV 7S domain (P4NP 7S) has been recently reported to be correlated with haemodynamics in patients with acute heart failure. We investigated whether these markers reflect cardiac remodelling and myocardial collagen expression. Read More

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http://dx.doi.org/10.1002/ehf2.12360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301156PMC
December 2018
2 Reads

Fourteen-year-old boy with decreased appetite and pedal swelling.

Heart 2018 Sep 21. Epub 2018 Sep 21.

Department of Cardiology, Christian Medical College, Vellore, Tamil Nadu, India.

CLINICAL INTRODUCTION: A 14-year-old boy presented with history of decreased appetite and bilateral swelling of feet for 6 months. He did not give any associated history of orthopnoea or paroxysmal nocturnal dyspnoea. He was born by a normal delivery after a non-consanguineous marriage. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313646DOI Listing
September 2018
2 Reads
5.595 Impact Factor

GPR30 Attenuates Myocardial Fibrosis in Diabetic Ovariectomized Female Rats: Role of iNOS Signaling.

DNA Cell Biol 2018 Oct 18;37(10):821-830. Epub 2018 Sep 18.

1 Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University , Xi'an, Shaanxi, China .

Premenopausal women have a reduced risk for cardiovascular disease. Estrogen deficiency augments cardiac inflammation and oxidative stress and, thereby, aggravates myocardial fibrosis (MF) and diastolic dysfunction in hypertensive female rats. However, estrogen replacement therapy has no effect on myocardial infarction and cardiac fibrosis in postmenopausal women. Read More

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http://dx.doi.org/10.1089/dna.2018.4208DOI Listing
October 2018
2 Reads

Hirudin Protects Ang II-Induced Myocardial Fibroblasts Fibrosis by Inhibiting the Extracellular Signal-Regulated Kinase1/2 (ERK1/2) Pathway.

Med Sci Monit 2018 Sep 8;24:6264-6272. Epub 2018 Sep 8.

Department of Cardiology, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, China (mainland).

BACKGROUND Myocardial fibrosis is closely related to all types of cardiovascular diseases. Hirudin is widely used in the prevention and treatment of cardiovascular diseases and cancers. In this study, we examined the potential role(s) and mechanism of hirudin in angiotensin II (Ang II)-induced myocardial fibrosis. Read More

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http://dx.doi.org/10.12659/MSM.909044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140377PMC
September 2018
2 Reads

Endomyocardial Fibrosis With End-Stage Heart Failure as a Consequence of a Myeloproliferative Neoplasm With Hypereosinophilia.

Can J Cardiol 2018 Sep 5;34(9):1233.e13-1233.e15. Epub 2018 Jun 5.

Pathology Department, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Forensic Pathology, Central Branch, Instituto Nacional de Medicina Legal e Ciências Forenses, Coimbra, Portugal.

Hypereosinophilic syndrome is characterized by an overproduction of eosinophils that infiltrate and damage multiple organs. Cardiac dysfunction occurs frequently and is a main cause of morbidity and mortality. We describe the case of a middle-aged man diagnosed with a myeloproliferative neoplasm associated with hypereosinophilia and treated with imatinib. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.05.024DOI Listing
September 2018
13 Reads

Isolated right ventricle endomyocardial fibrosis. An increasingly frequent disease in Spain.

Med Clin (Barc) 2018 Aug 23. Epub 2018 Aug 23.

Servicio de Cardiología, Complexo Hospitalario Universitario A Coruña, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña, A Coruña, España.

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http://dx.doi.org/10.1016/j.medcli.2018.06.014DOI Listing
August 2018
2 Reads

Endomyocardial fibrosis complicating primary hypereosinophilic syndrome.

Intensive Care Med 2018 Jul 13. Epub 2018 Jul 13.

Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Nice, 06200, Nice, France.

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http://dx.doi.org/10.1007/s00134-018-5300-zDOI Listing
July 2018
3 Reads

FIP1L1-PDGFRA fusion-negative hypereosinophilic syndrome with uncommon cardiac involvement responding to imatinib treatment: A case report.

Mol Clin Oncol 2018 Jul 21;9(1):35-39. Epub 2018 May 21.

Santa Terezinha University Hospital, Joaçaba, Santa Catarina 89600-000, Brazil.

Hypereosinophilic syndrome is a rare, chronic hematological disease characterized by a persistently elevated eosinophil count exceeding 1.5×10/l, following the exclusion of other potential etiologies. The systemic involvement of the disease causes tissue damage through eosinophil infiltration, and may affect various organs; cardiac complications are observed in 50-60% of cases, which are predominately attributed to endomyocardial fibrosis. Read More

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http://dx.doi.org/10.3892/mco.2018.1637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031893PMC
July 2018
2 Reads

Clinical utility of endomyocardial biopsies in the diagnosis of arrhythmogenic right ventricular cardiomyopathy in children.

Pediatr Res 2018 Oct 6;84(4):552-557. Epub 2018 Jul 6.

Division of Cardiology, The Hospital for Sick Children, Toronto, ON, Canada.

Background: Histomorphometry of endomyocardial biopsies is one component of arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnosis, although there is a need for stricter diagnostic criteria for this disease in pediatrics. The clinical utility of biopsy analysis as a component of ARVC diagnosis was evaluated in pediatric patients.

Methods: Histomorphometric analysis of fibrofatty infiltrate was completed on pediatric right ventricular endomyocardial biopsy samples. Read More

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http://dx.doi.org/10.1038/s41390-018-0093-xDOI Listing
October 2018
24 Reads
2.314 Impact Factor

Right Heart-Pulmonary Circulation Unit in Cardiomyopathies and Storage Diseases.

Heart Fail Clin 2018 Jul;14(3):311-326

Department of Advanced Biomedical Sciences, Federico II University of Naples, Via Bianchi, Naples 80100, Italy.

Cardiomyopathies (CM) are a heterogeneous group of muscle heart diseases, divided into 3 main categories (dilated, hypertrophic, and restrictive). In addition to these subgroups, athlete's heart and hypertensive cardiopathy are both the result of heart adaptation to increased loading conditions, making it possible to include them in the CM group. Right heart involvement is clear in some CM as arrhythmogenic CM, carcinoid syndrome, and endomyocardial fibrosis, whereas in others, like hypertrophic or dilated CM, it is known that the right heart has a prognostic impact but less clear is its pathogenic role. Read More

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http://dx.doi.org/10.1016/j.hfc.2018.03.001DOI Listing
July 2018
5 Reads
1.410 Impact Factor

Myocardial Infarct After Marijuana Inhalation in a 16-year-old Adolescent Boy.

Pediatr Dev Pathol 2018 06 29:1093526618785552. Epub 2018 Jun 29.

1 Harvard Medical Toxicology Program, Boston Children's Hospital, Boston, Massachusetts.

Many reports of marijuana-associated myocardial infarct (MI) are limited by incomplete evaluation of the toxicologic exposure, a lack of definitive anatomic findings, and the potential for comorbid coronary atherosclerosis inherent in an adult population. We report a 16-year-old adolescent boy who presented with chest pain after smoking marijuana and was found to have acute MI. Electrocardiogram showed diffuse ST-segment elevations. Read More

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http://dx.doi.org/10.1177/1093526618785552DOI Listing
June 2018
4 Reads

[Hypereosinophilic syndrome associated with cardiac involvement].

Pan Afr Med J 2017 28;28:270. Epub 2017 Nov 28.

Service de Cardiologie, Hôpital Habib Thameur, Tunis.

We report the case of a 30-year old man with no previous medical history and without cardiovascular risk factors, hospitalized for NYHA Class IV dyspnoea associated with palpitations in the Department of Cardiology. Clinical examination showed signs of cardiac decompensation. The patient didn't have fever, hepatosplenomegaly and palpable lymphadenopathies. Read More

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http://dx.doi.org/10.11604/pamj.2017.28.270.14316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011009PMC
July 2018
2 Reads

Eosinophilia to endomyocardial fibrosis: Documentation of a case.

Ann Pediatr Cardiol 2018 May-Aug;11(2):207-210

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

Endomyocardial fibrosis (EMF) is an important cause of restrictive cardiomyopathy in tropical countries. The etiopathogenesis of EMF remains obscure. The role of eosinophilia in the etiopathogenesis of EMF has been debated extensively, but remains unproven. Read More

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http://dx.doi.org/10.4103/apc.APC_143_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963239PMC
June 2018
2 Reads

The Role of MicroRNA-181a in Myocardial Fibrosis Following Myocardial Infarction in a Rat Model.

Med Sci Monit 2018 Jun 16;24:4121-4127. Epub 2018 Jun 16.

Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (mainland).

BACKGROUND The role of miR-181a in the development of cardiac disease and in particular, myocardial fibrosis following myocardial infarction (MI) remains unknown. The aim of this study was to explore the role of miR-181a in myocardial fibrosis in a rat model of MI and the expression of TGF-β receptor III (TβRIII). MATERIAL AND METHODS Forty adult male Wistar rats were randomly divided into an MI model group (n=30) and a control group with (n=10). Read More

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http://dx.doi.org/10.12659/MSM.908056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036961PMC
June 2018
2 Reads

Heart Failure in Sub-Saharan Africa.

Card Fail Rev 2018 May;4(1):21-24

Centre for Experimental Medicine, Queens University Belfast, Northern Ireland.

Heart failure is a growing problem in sub-Saharan Africa. This arises as the prevalence of risk factors for cardiovascular disease rises, life expectancy increases and causes of heart failure more common in Africa, such as rheumatic heart disease and endomyocardial fibrosis, continue to be a significant issue. Lack of access to diagnostics is an issue with the expense and technical expertise required for echocardiography limiting access. Read More

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http://dx.doi.org/10.15420/cfr.2018:4:1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971674PMC
May 2018
1 Read

Non parasitic hypereosinophilia revealing biventricular endomyocardial fibrosis.

Pan Afr Med J 2018;29:58. Epub 2018 Jan 22.

Cardiology Department, Faculty of Medicine and Pharmacy of Rabat, University Mohammed V, Rabat, Morocco.

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http://dx.doi.org/10.11604/pamj.2018.29.58.14560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987148PMC
January 2018
1 Read

Quantitative Differentiation of LV Myocardium with and without Layer-Specific Fibrosis Using MRI in Hypertrophic Cardiomyopathy and Layer-Specific Strain TTE Analysis.

Int Heart J 2018 May 9;59(3):523-530. Epub 2018 May 9.

Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine.

To achieve further risk stratification in hypertrophic cardiomyopathy (HCM) patients, we localized and quantified layer-specific LVM fibrosis on MRI in HCM patients using regional layer-specific peak longitudinal strain (PLS) and peak circumferential strain (PCS) in LV myocardium (LVM) on speckle tracking transthoracic echocardiography (TTE). A total of 18 HCM patients (14 males; 58 ± 17 years) underwent 1.5T-MRI and TTE. Read More

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http://dx.doi.org/10.1536/ihj.17-208DOI Listing
May 2018
4 Reads

Case Report: Probable Case of Spontaneous Encephalopathy Due to Loiasis and Dramatic Reduction of Microfilariaemia with Prolonged Repeated Courses of Albendazole.

Am J Trop Med Hyg 2018 Jul 3;99(1):112-115. Epub 2018 May 3.

Centre for Research on Filariasis and other Tropical Diseases (CRFilMT), Yaoundé, Cameroon.

Loiasis is a vector-borne parasitic disease caused by the filarial nematode and transmitted by the tabanid vectors from the genus . infection is associated with clinical manifestations such as pruritus, migratory transient edema, passage of adult worm in the bulbar conjunctiva, retinal damage, glomerular damage, albuminuria, pleural effusion, hydrocele, and endomyocardial fibrosis. Data reporting the occurrence of spontaneous encephalopathy associated with loiasis are very scanty. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085801PMC
July 2018
2 Reads

Myocardial perfusion reserve and global longitudinal strain as potential markers of coronary allograft vasculopathy in late-stage orthotopic heart transplantation.

Int J Cardiovasc Imaging 2018 Oct 4;34(10):1607-1617. Epub 2018 May 4.

Department of Medicine, University of Chicago Medicine, 5758 S. Maryland Avenue, MC9067, Chicago, IL, 60637, USA.

Coronary allograft vasculopathy (CAV) is a major cause of mortality in late-stage orthotopic heart transplantation (OHT) patients. Recent evidence has shown that myocardial perfusion reserve (MPR) derived from vasodilator cardiovascular magnetic resonance imaging (vCMR) and global longitudinal strain (GLS) from transthoracic echocardiography (TTE) are useful to detect CAV. However, previous studies have not comprehensively addressed whether these parameters are confounded by allograft rejection, myocardial scar/fibrosis, or allograft dysfunction. Read More

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http://link.springer.com/10.1007/s10554-018-1364-7
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http://dx.doi.org/10.1007/s10554-018-1364-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160357PMC
October 2018
5 Reads
2.322 Impact Factor

Prevalence and characteristics of primary left-sided valve disease in a cohort of 15,000 patients undergoing echocardiography studies in a tertiary hospital in Uganda.

BMC Cardiovasc Disord 2018 May 4;18(1):82. Epub 2018 May 4.

Uganda Heart Institute, Kampala, Uganda.

Background: Although rheumatic heart disease remains the leading cause of valve heart disease (VHD) in developing countries, other forms of valve disease have been over shadowed and not regarded as a public health problem. However, several facts suggest that the role of non-rheumatic VHD as a significant cardiovascular disease should be reconsidered. We aimed to assess the prevalence and characteristics of different forms of primary left sided valve diseases from a series of 15,009 echocardiographic studies. Read More

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https://bmccardiovascdisord.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s12872-018-0813-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935941PMC
May 2018
12 Reads

Recurrent symptomatic ischemic stroke in a 46-year-old African male revealing Angio-Behçet with severe cardiovascular involvement.

Egypt Heart J 2017 Mar 13;69(1):75-80. Epub 2016 Oct 13.

Department of Cardiology and Internal Medicine, Military Hospital of Ouakam, Dakar, Senegal.

Behçet'sdisease (BD) is a chronic, multisystem vasculitis. It is categorized under variable vessel vasculitis in the new Chapel Hill nomenclature as it involves blood vessels of any type and size. It is characterized by relapsing aphthous ulcers commonly occurring in the oral mucosa and genitalia with ocular involvement. Read More

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http://dx.doi.org/10.1016/j.ehj.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839345PMC
March 2017
7 Reads

[Tropical endomyocardial fibrosis: Perspectives].

Ann Cardiol Angeiol (Paris) 2018 Apr 27;67(2):74-81. Epub 2018 Mar 27.

Instituto do Coraçao, 1111, avenue Kenneth-Kaunda, Maputo, Mozambique.

Tropical endomyocardial fibrosis (FET) is a leading cause of heart failure and the most common restrictive cardiomyopathy worldwide. Extensive fibrosis of the ventricular endocardium causing architectural distortion, impaired filling and valvular insufficiency define the disease. Confined to peculiar and limited geographical areas, the aetiology remains blurred and it carries a grim prognosis. Read More

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http://dx.doi.org/10.1016/j.ancard.2018.01.001DOI Listing
April 2018
1 Read

Fatal Cardiac Hemochromatosis in a Patient with Hereditary Spherocytosis.

Int Heart J 2018 Mar 20;59(2):427-430. Epub 2018 Mar 20.

Department of Cardiovascular Medicine, Kyushu University Hospital.

A 31-year-old man was admitted to our hospital with atrial tachycardia and cardiogenic shock. He had been diagnosed with hereditary spherocytosis (HS) during childhood, but he never received any red blood cell transfusions. Right ventricular endomyocardial biopsy revealed multiple myocardial hemosiderin deposits, and he was diagnosed with cardiac hemochromatosis. Read More

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http://dx.doi.org/10.1536/ihj.17-160DOI Listing
March 2018
4 Reads

Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature.

Medicine (Baltimore) 2018 Mar;97(11):e0079

Department of Cardiology, The First Hospital of Jilin University, Changchun, China.

Rationale: Hypereosinophilic syndrome (HES) is a rare disease characterized by hypereosinophilia and its ensuing organ damage. Cardiac involvement is divided into 3 chronological stages: an acute necrotic stage; a thrombus formation stage; and a fibrotic stage. Infiltration of the myocardium by eosinophilic cells followed by endomyocardial fibrosis is known as "Loeffler endocarditis. Read More

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http://dx.doi.org/10.1097/MD.0000000000010079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882404PMC
March 2018
11 Reads

Multimodality imaging in endomyocardial fibrosis associated with Hodgkin lymphoma.

Eur Heart J Cardiovasc Imaging 2018 07;19(7):824

Institute of Nuclear Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic.

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http://dx.doi.org/10.1093/ehjci/jey032DOI Listing
July 2018
5 Reads

Myocardial Extracellular Volume Quantification by Cardiovascular Magnetic Resonance and Computed Tomography.

Curr Cardiol Rep 2018 03 6;20(3):15. Epub 2018 Mar 6.

Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, 2nd Floor, King George V Building, West Smithfield, London, EC1A 7BE, UK.

Purpose Of Review: This review article discusses the evolution of extracellular volume (ECV) quantification using both cardiovascular magnetic resonance (CMR) and computed tomography (CT).

Recent Findings: Visualizing diffuse myocardial fibrosis is challenging and until recently, was restricted to the domain of the pathologist. CMR and CT both use extravascular, extracellular contrast agents, permitting ECV measurement. Read More

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http://dx.doi.org/10.1007/s11886-018-0961-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840231PMC
March 2018
7 Reads

Endocardial Fibrotic Lesions Have a Greater Effect on Peak Longitudinal Strain than Epicardial Fibrotic Lesions in Hypertrophic Cardiomyopathy Patients.

Int Heart J 2018 Mar 23;59(2):347-353. Epub 2018 Feb 23.

Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine.

Peak longitudinal strain (PLS) of the left ventricular (LV) myocardium by transthoracic echocardiogram (TTE) is useful to detect LV myocardial damage. We hypothesized that myocardial fibrosis (MF) in the LV myocardium may influence PLS. Eighteen hypertrophic cardiomyopathy (HCM) patients (14 males; 58 ± 17 years old) underwent 1. Read More

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http://dx.doi.org/10.1536/ihj.17-021DOI Listing
March 2018
2 Reads

LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d.

Theranostics 2018 2;8(4):1180-1194. Epub 2018 Feb 2.

Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150081, P. R. China.

Cardiac fibrosis is associated with various cardiovascular diseases and can eventually lead to heart failure. Dysregulation of long non-coding RNAs (lncRNAs) has recently been recognized as one of the key mechanisms involved in cardiac diseases. However, the potential roles and underlying mechanisms of lncRNAs in cardiac fibrosis have not been explicitly delineated. Read More

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http://www.thno.org/v08p1180.htm
Publisher Site
http://dx.doi.org/10.7150/thno.20846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817119PMC
January 2019
8 Reads

Geographical variation in the clinical presentation of endomyocardial fibrosis in India?

Indian Heart J 2018 Jan - Feb;70(1):56-65. Epub 2017 Jan 30.

Medical College Hospital, Trivandrum, India.

Objectives: To compare the clinical presentation, clinical profile and survival of two groups of endomyocardial fibrosis patients.

Methods: The study was a prospective cohort study, or a prospective case series, comparing all consecutive echocardiographically proven patients with endomyocardial fibrosis seen in Medical College Trivandrum with the patients seen in Medical College Hospital, Alappuzha(Alleppey) (or TD Medical College). In all patients the clinical details like age, sex, type of endomyocardial fibrosis, the presence of anaemia, eosinophilia, neutrophilia and type of rhythm(Sinus or atrial fibrillation) etc were compared by both simple X2 and by Kaplan Meier survival curves. Read More

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http://dx.doi.org/10.1016/j.ihj.2016.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902820PMC
July 2018
4 Reads

Doxycycline attenuates chronic intermittent hypoxia-induced atrial fibrosis in rats.

Cardiovasc Ther 2018 Jun 2;36(3):e12321. Epub 2018 Mar 2.

Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China.

Introduction: Atrial structural remodeling in the form of fibrosis contributes to the arrhythmic substrate in atrial fibrillation (AF). The aim of this study was to investigate the effects of doxycycline on chronic intermittent hypoxia (CIH)-induced atrial fibrosis and the pathophysiological mechanisms underlying such changes.

Methods: A total of 30 Sprague Dawley rats were randomized into three groups: control group, CIH group, and CIH with doxycycline treatment (CIH-D) group. Read More

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http://dx.doi.org/10.1111/1755-5922.12321DOI Listing
June 2018
9 Reads

Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-term life-threatening arrhythmias.

Eur Heart J 2018 Mar;39(10):864-873

Department of Cardiology, Maastricht University Medical Centre, Center for Heart Failure Research, Cardiovascular Research Institute Maastricht (CARIM), University Hospital Maastricht, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands.

Aims: Truncating titin variants (TTNtv) are the most prevalent genetic cause of dilated cardiomyopathy (DCM). We aim to study clinical parameters and long-term outcomes related to the TTNtv genotype and determine the related molecular changes at tissue level in TTNtv DCM patients.

Methods And Results: A total of 303 consecutive and extensively phenotyped DCM patients (including cardiac imaging, Holter monitoring, and endomyocardial biopsy) underwent DNA sequencing of 47 cardiomyopathy-associated genes including TTN, yielding 38 TTNtv positive (13%) patients. Read More

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http://dx.doi.org/10.1093/eurheartj/ehx808DOI Listing
March 2018
20 Reads

Both left ventricular papillary muscles necrosis, an eosinophylic lymphoblastic leukemia revealed by endomyocardial fibrosis.

Presse Med 2018 Feb 1;47(2):185-189. Epub 2018 Feb 1.

Hôpital cardiologique Haut-Lévêque, avenue de Magellan, 33604 Pessac, France.

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http://dx.doi.org/10.1016/j.lpm.2017.10.023DOI Listing
February 2018
3 Reads

Characterization of Cardiopulmonary Exercise Testing Variables in Patients with Endomyocardial Fibrosis after Endocardial Resection.

Arq Bras Cardiol 2017 Dec;109(6):533-540

Instituto do Coração (InCor) - Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP - Brazil.

Background: Endomyocardial fibrosis (EMF) is a rare disease, characterized by diastolic dysfunction which leads to reduced peak oxygen consumption (VO2). Cardiopulmonary exercise testing (CPET) has been proved to be a fundamental tool to identify central and peripheral alterations. However, most studies prioritize peak VO2 as the main variable, leaving aside other important CPET variables that can specify the severity of the disease and guide the clinical treatment. Read More

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http://dx.doi.org/10.5935/abc.20170179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783434PMC
December 2017
33 Reads

Right Ventricular Myofilament Functional Differences in Humans With Systemic Sclerosis-Associated Versus Idiopathic Pulmonary Arterial Hypertension.

Circulation 2018 May 19;137(22):2360-2370. Epub 2018 Jan 19.

Divisions of Cardiology (S.H., K.M.K.-S., M.M., D.A.K.).

Background: Patients with systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) have a far worse prognosis than those with idiopathic PAH (IPAH). In the intact heart, SSc-PAH exhibits depressed rest and reserve right ventricular (RV) contractility compared with IPAH. We tested whether this disparity involves underlying differences in myofilament function. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.033147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976528PMC
May 2018
15 Reads
3 Citations
14.430 Impact Factor