46,830 results match your criteria Endometrium Carcinoma

Limited role of GeneXpert in peritoneal fluid in the diagnosis of genital tuberculosis in infertile women.

J Family Med Prim Care 2021 Apr 29;10(4):1656-1660. Epub 2021 Apr 29.

Department of Statistics, Lucknow University, Lucknow, Uttar Pradesh, India.

Background And Objectives: Genital tuberculosis (TB) is an important cause of infertility in women that poses many challenges in diagnosis. The study is done to understand the utility of GeneXpert test in peritoneal fluid in the diagnosis of genital TB in infertile women.

Methods: All infertile women in postmenstrual phase who were planned for laparoscopy in study period were included. Read More

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Histopathological Account of Obstetrical and Gynecological Specimens: Retrospective Study at a Tertiary Care Center of Peshawar.

Cureus 2021 May 11;13(5):e14950. Epub 2021 May 11.

Cardiothoracic Surgery, Rehman Medical Institute, Peshawar, PAK.

Introduction Histopathologic specimen examination of surgically isolated organs and tissues yields valuable information regarding a disease process and plays a vital role in the future management of a patient. Our aim was to account for the common diagnosis yielded from histopathological specimens of the obstetrics and gynecology department and to determine if all the obstetric and gynecological specimens should be routinely sent for histopathology. Methods A retrospective, cross-sectional study was conducted at the histopathology unit of a tertiary care hospital in Peshawar. Read More

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Altrenogest during early pregnancy modulates uterine glandular epithelium and endometrial growth factor expression at the time implantation in pigs.

Anim Reprod 2021 May 28;18(1):e20200431. Epub 2021 May 28.

Departamento de Reprodução Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Pirassununga, SP, Brasil.

This study evaluated the effects of supplying altrenogest from day 6-12 of pregnancy on the endometrial glandular epithelium, corpora lutea (CL) morphology, and endometrial and CL gene expression. A total of 12 crossbred females (Landrace × Large White) were used. The females were assigned to 4 treatments according to a random design with a 2 × 2 factorial arrangement, with two categories (sow or gilt) and two treatments (non-treated and treated with altrenogest). Read More

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Current and Future Roles of Circular RNAs in Normal and Pathological Endometrium.

Front Endocrinol (Lausanne) 2021 26;12:668073. Epub 2021 May 26.

Department of Gynecology, Shenzhen Second People's Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China.

The uterine endometrium, which lines the mammalian uterus, is essential for embryo implantation. This lining undergoes significant changes during sexual and menstrual cycles. The endometrium is also associated with hormone-related diseases such as endometriosis and endometrial cancer. Read More

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Noncanonical functions of glucocorticoids: A novel role for glucocorticoids in performing multiple beneficial functions in endometrial stem cells.

Cell Death Dis 2021 Jun 12;12(6):612. Epub 2021 Jun 12.

Department of Biomedical Science, Jungwon University, Goesan-gun, Chungcheongbuk-do, Republic of Korea.

Chronic stress has a negative impact on many fertility-related functions; thus, the recent decline in female fertility seems to be at least partially associated with increased stress. The secretion of glucocorticoids is a typical endocrine response to chronic stress and indirectly reduces uterine receptivity through the hypothalamus-pituitary-gonadal (HPG) axis. However, in addition to its well-known canonical role, the direct effects of chronic stress-induced glucocorticoids on various uterine functions and their underlying molecular mechanisms are complex and have not yet been revealed. Read More

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The Effect of Sildenafil Citrate on Poor Endometrium in Patients Undergoing Frozen-Thawed Embryo Transfer following Resection of Intrauterine Adhesions: A Retrospective Study.

Gynecol Obstet Invest 2021 Jun 11:1-8. Epub 2021 Jun 11.

Department of Reproductive Medicine, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, China.

Background: The recent studies have shown that sildenafil citrate can enhance estrogen-induced proliferation of the endometrium in infertile women.

Objective: This study was aimed to investigate whether sildenafil citrate could affect pregnancy outcomes in infertile women receiving frozen-thawed embryo transfer (FET) after resection of intrauterine adhesions (IUAs).

Materials And Methods: A total of 310 subjects who met the inclusion criteria were recruited and divided into the control group (group A) and the sildenafil citrate group (or the SC group, group B). Read More

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Nicotine and modafinil combination protects against the neurotoxicity induced by 3,4-Methylenedioxymethamphetamine in hippocampal neurons of male rats.

J Chem Neuroanat 2021 Jun 10;116:101986. Epub 2021 Jun 10.

Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Science, Tehran, Iran; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

MDMA (3,4-Methylenedioxymethamphetamine) is a common recreational drug of abuse which causes neurodegeneration. Nicotine and modafinil provide antioxidant and neuroprotective properties and may be beneficial in the management of MDMA-induced neurotoxicity. The purpose of this study was to characterize how acute and chronic administration of nicotine and/or modafinil exert protective effects against the MDMA-induced impaired cognitive performance, oxidative stress, and neuronal loss. Read More

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Injectable Mesenchymal Stem Cell-Laden Matrigel Microspheres for Endometrium Repair and Regeneration.

Adv Biol (Weinh) 2021 Jun 12:e2000202. Epub 2021 Jun 12.

Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, 518055, China.

Endometrial injury and intrauterine adhesions are increasingly reported in recent years; however, treatment options remain limited. Intravenous injection of mesenchymal stem cells (MSCs) for endometrium regeneration has limited effectiveness as the retention rate of transplanted cells is low. Hydrogel-based tissue-engineered solutions, such as MSC-seeded bioscaffolds, are reported to increase retention rates; however, a less invasive alternative is still desirable. Read More

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Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis.

Mol Cell Biochem 2021 Jun 11. Epub 2021 Jun 11.

Department of Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, No. 1 Zhongshan Second Road, Yuexiu District, Guangzhou, 510080, Guangdong, China.

Endometriosis is an estrogen-dependent disease. Several researches have reported the dysregulated circular RNAs (circRNAs) in endometriosis, whereas the functions of circRNAs are largely unknown. This study aims to explore the role and mechanism of circ_0075503 in migration and invasion of eutopic endometrial stromal cells. Read More

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CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium.

BMC Womens Health 2021 06 11;21(1):240. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, People's Hospital of Jiaxiang County, No. 188 Yingfeng Road, Jiaxiang, Jining, 272400, Shandong, China.

Background: This study aimed to explore the molecular mechanisms of tibolone treatment in postmenopausal women.

Methods: The gene set enrichment profile, GSE12446, which includes 9 human endometrial samples from postmenopausal women treated with tibolone (tibolone group) and 9 control samples (control group), was downloaded from GEO database for analysis. Differentially expressed genes (DEGs) in tibolone vs. Read More

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Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.

J Reprod Immunol 2021 Jun 2;146:103341. Epub 2021 Jun 2.

Laboratory of Neurobiology, College of Veterinary Medicine, China Agricultural University, Beijing, Haidian, 100193, People's Republic of China; Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, China Agricultural University, Beijing, Haidian, 100193, People's Republic of China. Electronic address:

Infertility is a prevalent female reproductive disease worldwide. Currently, there are many unknown etiologies of infertility. N6-methyladenosine (m6A) is the most prevalent modification of eukaryotic mRNA. Read More

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Analysis of Transcripts of Uncertain Coding Potential Using RNA Sequencing During the Preattachment Phase in Goat Endometrium.

DNA Cell Biol 2021 Jun 11. Epub 2021 Jun 11.

College of Animal Science, South China Agricultural University, Guangzhou, China.

Transcripts of uncertain coding potential (TUCP) are part of long noncoding RNAs, which include short open reading frames and could be translated into small peptides. In recent years, a growing number of TUCPs has been implicated in multiple biological activities, such as embryogenesis and transcriptional regulation. However, the abundance of TUCPs and their roles in goat endometrium during pregnancy recognition (day 16) remain undocumented. Read More

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Understanding the Impact of Uterine Fibroids on Human Endometrium Function.

Front Cell Dev Biol 2021 25;9:633180. Epub 2021 May 25.

Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, United States.

Uterine fibroids (leiomyomas) are the most common benign gynecological tumors in women of reproductive age worldwide. They cause heavy menstrual bleeding, usually leading to severe anemia, pelvic pain/pressure, infertility, and other debilitating morbidities. Fibroids are believed to be monoclonal tumors arising from the myometrium, and recent studies have demonstrated that fibroids actively influence the endometrium globally. Read More

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Adjuvant Therapy for High-risk Endometrial Carcinoma.

J Perera P Hoskin

Clin Oncol (R Coll Radiol) 2021 Jun 7. Epub 2021 Jun 7.

Mount Vernon Cancer Centre, Northwood, UK; Division of Cancer Sciences, University of Manchester, Manchester, UK. Electronic address:

About one-fifth of endometrial cancers are 'high risk', which carries a poorer prognosis. Management strategies to optimise their survival have been under investigation for many years. Despite recent advances, their overall survival remains relatively poor. Read More

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Human endometrium-derived stem cell improves cardiac function after myocardial ischemic injury by enhancing angiogenesis and myocardial metabolism.

Stem Cell Res Ther 2021 Jun 10;12(1):344. Epub 2021 Jun 10.

The Laboratory of Stem Cell Regenerative Medicine Research, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Key Laboratory of Cell Physiology of Ministry of Education, Shanxi Medical University, Taiyuan, China.

Background: The human endometrium in premenopausal women is an active site of physiological angiogenesis, with regenerative cells present, suggesting that the endometrium contains adult angiogenic stem cells. In the context of cardiac repair after ischemic injury, angiogenesis is a crucial process to rescue cardiomyocytes. We therefore investigated whether human endometrium-derived stem cells (hEMSCs) can be used for cardiac repair after ischemic injury and their possible underlying mechanisms. Read More

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Dual agonist-antagonist effect of ulipristal acetate in human endometrium and myometrium.

Expert Rev Mol Diagn 2021 Jun 10. Epub 2021 Jun 10.

Departamento de Bioquímica, Microbiología, Biología Celular y Genética, Universidad de La Laguna. Facultad de Ciencias. Sección de Biología. Avda. Astrofísico Fco. Sánchez s/n. 38200. San Cristóbal de La Laguna, Tenerife, Spain.

. The aim of this study was to assess the molecular effect of ulipristal acetate (UPA) on gene expression in myometrium and endometrium of patients with symptomatic fibroids.: Tissues isolated from four women treated preoperatively with UPA (5 mg) were compared to those from untreated controls using Nanostring platform to assess the expression of 75 candidate genes modulated by UPA and ovarian steroids. Read More

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The impact of the female genital tract microbiome in women health and reproduction: a review.

J Assist Reprod Genet 2021 Jun 10. Epub 2021 Jun 10.

IVIRMA Valencia, Plaza de la Policía Local, 3, 46015, Valencia, Spain.

Purpose: The aim of this review is to gather the available research focusing on female genital tract (FGT) microbiome. Research question focuses in decipher which is the role of FGT microbiota in eubiosis, assisted reproduction techniques (ARTs), and gynaecological disorders, and how microbiome could be utilised to improve reproduction outcomes and to treat fertility issues.

Methods: PubMed was searched for articles in English from January 2004 to April 2021 for "genital tract microbiota and reproduction", "endometrial microbiome", "microbiome and reproduction" and "microbiota and infertility". Read More

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Endometrial injury in women undergoing in vitro fertilisation (IVF).

Cochrane Database Syst Rev 2021 06 10;6:CD009517. Epub 2021 Jun 10.

SEMEAR Fertilidade, Reproductive Medicine, Ribeirao Preto, Brazil.

Background: Implantation of an embryo within the endometrial cavity is a critical step in the process of in vitro fertilisation (IVF). Previous research has suggested that endometrial injury (also known as endometrial scratching), defined as intentional damage to the endometrium, can increase the chance of pregnancy in women undergoing IVF.

Objectives: To assess the effectiveness and safety of endometrial injury performed before embryo transfer in women undergoing in vitro fertilisation (IVF) including intracytoplasmic sperm injection (ICSI) and frozen embryo transfer. Read More

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Prostaglandin E2 promotes Staphylococcus aureus infection via EP4 receptor in bovine endometrium.

Microb Pathog 2021 Jun 6;158:105019. Epub 2021 Jun 6.

Laboratory of Veterinary Pathology, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China. Electronic address:

Prostaglandin E2 (PGE) enhances Staphylococcus aureus infection but its mechanism is not well understood. Here, we examined the effect of PGE on Staphylococcal Protein A (SPA) expression in bovine endometrium and determined the role of select PGE receptors (i.e. Read More

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Stem Cell-Based Therapy for Asherman Syndrome: Promises and Challenges.

Cell Transplant 2021 Jan-Dec;30:9636897211020734

Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, China.

Asherman syndrome (AS) has an adverse effect on reproductive health and fertility by affecting endometrial regeneration. Stem cell-based therapies hold promise for future use in activating non-functional endometrium and reconstructing the endometrium in vivo. It has been postulated that various endometrial stem cells (EnSCs) are responsible for endometrial regeneration. Read More

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Gynecological malignancies at tertiary care hospital, Pakistan: A five-year review.

Pak J Med Sci 2021 May-Jun;37(3):621-627

Dr. Gul e Raana, FCPS. Department of Gynecology, Services Institute of Medical Sciences, Lahore, Pakistan.

Background & Objective: Gynecological malignancies are important cause of female morbidity and mortality. They pose significant burden on health resources in low middle-income countries. Data on presentation and risk factors can help in early identification and reduce this burden. Read More

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Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature.

Int J Womens Health 2021 1;13:525-537. Epub 2021 Jun 1.

Laboratory of Clinical Morphology, Research Institute of Human Morphology, Moscow, Russia.

Objective: To review the mechanisms of endometriosis development, including those related to epigenetic mutations, cellular dysregulation, inflammatory processes, and oxidative stress.

Methods: A systematic literature review regarding current aspects of endometriosis etiology, genesis and development was performed using the PubMed, Google Scholar, and eLibrary databases. Keywords included endometriosis, etiology, development, genesis, associations and mechanisms. Read More

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"Identification and characterization of endometrial carcinoma with tumor markers HE4 and CA125 in serum and endometrial tissue samples and systematic review of the literature".

J Turk Ger Gynecol Assoc 2021 Jun 8. Epub 2021 Jun 8.

Department of Gynecology Oncology, Hospital Puerta de Hierro, Madrid, Spain.

Objective: The diagnosis of endometrial cancer is made by biopsy sampling with pathological analysis, but it is extremely important to make an accurate diagnosis in order to plan the specific treatment, and we suggest that HE4 in the endometrial tissue and in serum could be tools to make the diagnosis more precise.

Material And Methods: Our prospective study compared patients with endometrial cancer against non-endometrial cancer ones, matched with several variables. The inclusion criteria were females older than 18 years old that accepted to participate in the research study but that had never underwent surgery for other oncological pathologies, whether for ovarian, colon, cervical carcinoma or uterine sarcoma, and none of them had received preoperative chemo or radiotherapy; moreover, they could not have any severe renal or liver pathology. Read More

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ALDH1 expression predicts progression of premalignant lesions to cancer in Type I endometrial carcinomas.

Sci Rep 2021 Jun 7;11(1):11949. Epub 2021 Jun 7.

4525 MacDonald Research Laboratories, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.

In type 1 endometrial cancer, unopposed estrogen stimulation is thought to lead to endometrial hyperplasia which precedes malignant progression. Recent data from our group and others suggest that ALDH activity mediates stemness in endometrial cancer, but while aldehyde dehydrogenase 1 (ALDH1) has been suggested as a putative cancer stem cell marker in several cancer types, its clinical and prognostic value in endometrial cancer remains debated. The aim of this study was to investigate the clinical value of ALDH1 expression in endometrial hyperplasia and to determine its ability to predict progression to endometrial cancer. Read More

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Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis.

Nat Commun 2021 06 7;12(1):3386. Epub 2021 Jun 7.

Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.

During early pregnancy in the mouse, nidatory estrogen (E2) stimulates endometrial receptivity by activating a network of signaling pathways that is not yet fully characterized. Here, we report that bone morphogenetic proteins (BMPs) control endometrial receptivity via a conserved activin receptor type 2 A (ACVR2A) and SMAD1/5 signaling pathway. Mice were generated to contain single or double conditional deletion of SMAD1/5 and ACVR2A/ACVR2B receptors using progesterone receptor (PR)-cre. Read More

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Implantation Model Using Human Endometrial SUSD2+ Mesenchymal Stem Cells and Myometrial Smooth Muscle Cells.

Cell J 2021 Jul 26;23(2):154-163. Epub 2021 May 26.

Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Email:

Objective: This study evaluated a novel implantation model using human endometrial mesenchymal stem cells (EMSCs), SUSD2+, and myometrial smooth muscle cells (SMCs) that were co-cultured with mouse blastocysts as the surrogate embryo.

Materials And Methods: In this experimental study, SUSD2+ MSCs were isolated from human endometrial cell suspensions (ECS) at the fourth passage by magnetic-activated cell sorting. The ECS and SUSD2+ cells were separately co-cultured with human myometrial muscle cells for five days. Read More

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Corrigendum to 'Endometrial membrane organoids from human embryonic stem cell combined with the 3D Matrigel for endometrium regeneration in asherman syndrome' [Bioactive Mater. 6 (2021) 3935-3946].

Bioact Mater 2021 Dec 15;6(12):4591. Epub 2021 May 15.

Key Laboratory of Women's Reproductive Health Research of Zhejiang Province, Women's Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province, 310006, China.

[This corrects the article DOI: 10.1016/j.bioactmat. Read More

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December 2021

Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer.

Theranostics 2021 8;11(14):6950-6965. Epub 2021 May 8.

School of Medicine, Nankai University, Tianjin 300071, China.

Psychological stress has been linked to cancer development and resistance to therapy by many epidemiological and clinical studies. Stress-induced immunosuppressive microenvironment by stress hormones, in particular glucocorticoids, has been extensively studied. However, the impacts of other stress-related neurotransmitters, such as serotonin (5-hydroxytryptamine, 5-HT), on cancer development just start to be revealed. Read More

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Synchronous Occurrence of Ovarian Seromucinous Carcinoma and Endometrial Mucinous Carcinoma: A Case Report.

J UOEH 2021 ;43(2):235-242

Department of Obstetrics and Gynecology, School of Medicine, University of Occupational and Environmental Health, Japan.

Endometrioid carcinoma is the most common histological type of concurrent synchronous cancers of the uterus and ovary. Here we report a case of synchronous seromucinous carcinoma of the ovary and mucinous carcinoma of the endometrium with a literature review. A 51-year-old multiparous female complained of irregular bleeding and shortness of breath. Read More

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January 2021

Two decades of a protooncogene HPIP/PBXIP1: Uncovering the tale from germ cell to cancer.

Biochim Biophys Acta Rev Cancer 2021 Jun 5;1876(1):188576. Epub 2021 Jun 5.

Molecular and Cellular Oncology Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India. Electronic address:

Hematopoietic PBX interacting protein (HPIP or pre-B-cell leukemia transcription factor interacting protein (PBXIP1) was discovered two decades ago as a corepressor of pre-B-cell leukemia homeobox (PBX) 1 with a vital functional role in hematopoiesis. Later it emerged as a potential biomarker of poor prognosis and tumorigenesis for more than a dozen different cancers. It regulates aggressive cancer phenotypes, cell proliferation, metastasis, EMT, etc. Read More

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