42,774 results match your criteria Endometrium Carcinoma


Impairment of the antifibrotic prostaglandin E pathway may influence neutrophil extracellular traps-induced fibrosis in the mare endometrium.

Domest Anim Endocrinol 2018 Nov 3;67:1-10. Epub 2018 Nov 3.

Department of Morphology and Function, CIISA- Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

Prostaglandin E (PGE) has contradictory effects in many organs. It may have proinflammatory, anti-inflammatory, or anti-fibrotic roles, depending on the type of receptors to which it binds. By signaling through its receptors EP2 and EP4, PGE mediates anti-inflammatory and anti-fibrotic actions. Read More

View Article
November 2018
2 Reads

Uterine Cancer Incidence and Mortality - United States, 1999-2016.

MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1333-1338. Epub 2018 Dec 7.

Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC.

Uterine cancer is one of the few cancers with increasing incidence and mortality in the United States, reflecting, in part, increases in the prevalence of overweight and obesity since the 1980s (1). It is the fourth most common cancer diagnosed and the seventh most common cause of cancer death among U.S. Read More

View Article
December 2018
1 Read

My Womban's Life: Understanding Human Endometrial Function.

Authors:
Lois Salamonsen

Reproduction 2018 Dec 1. Epub 2018 Dec 1.

L Salamonsen, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Australia.

The focus of my life in science, has been to improve reproductive health for women, with an emphasis on the endometrium, the most dynamic tissue in the human body: its remarkable cyclical remodelling is essential for establishment of pregnancy. The most notable events in a woman's endometrial cycle are menstruation and endometrial repair, regeneration of the endometrium during the proliferative phase, attainment of receptivity by the mid-secretory phase of the cycle and the embryo-maternal interactions that initiate peri-implantation events within the microenvironment of the uterine cavity. I have contributed to understanding the molecular and cellular changes underpinning these events, and how disturbance of them leads to menstrual disorders, infertility and endometrial diseases including abnormal uterine bleeding, endometriosis and endometrial cancer. Read More

View Article
December 2018

The incidence and predictors of gynecologic malignancies among postmenopausal patients with endometrial fluid collection.

Authors:
Zhe Li Lei Li

Arch Gynecol Obstet 2018 Dec 5. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No 1, Dongcheng District, Beijing, China.

Objective: To investigate the incidence and predictors of gynecologic malignancies among postmenopausal patients with endometrial fluid collection (EFC).

Methods: All patients with EFC diagnosed by transvaginal sonography (TVS) were retrospectively reviewed if they had undergone biopsy of the endometrium from January 2008 to January 2016 in a tertiary teaching hospital. Follow-up ended in June 2017. Read More

View Article
December 2018
1.279 Impact Factor

Efficient treatment of chronic endometritis through a novel approach of intrauterine antibiotic infusion: a case series.

BMC Womens Health 2018 Dec 5;18(1):197. Epub 2018 Dec 5.

Centre for Human Reproduction, Genesis Athens Clinic, 14-16, Papanikoli 15232, Athens, Greece.

Background: Early diagnosis and efficient management of Chronic Endometritis (CE) in patients seeking fertility treatment are two components every practitioner wishes to address. With respect to endometrial restoration, antibiotic treatment appears to perform well. However, regarding the improvement of In Vitro Fertilization (IVF) success rates, literature evidence is inconclusive, and consensus on optimal treatment has yet to be reached. Read More

View Article
December 2018

The effect of orexin B on steroidogenic acute regulatory protein, p450 side chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase gene expression, progesterone and androstenedione secretion by the porcine uterus during early pregnancy and the oestrous cycle.

J Anim Sci 2018 Dec 2. Epub 2018 Dec 2.

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland.

The aim of this study was to investigate the effect of orexin B (OXB) on progesterone (P4) and androstenedione (A4) secretion by porcine endometrial and myometrial tissue explants and on the expression of key steroidogenic proteins and enzymes involved in steroid production. The hormones secretion and the expression of steroidogenic acute regulatory protein (StAR), P450 side-chain cleavage enzyme (CYP11A1) and 3β-hydroxysteroid dehydrogenase (HSD3B1) was analyzed on days 10 to 11, 12 to 13, 15 to 16, 27 to 28 of pregnancy and during the luteal phase of the oestrous cycle (days 10 to 11). Endometrial and myometrial explants were cultured in vitro in the presence of OXB (1, 10 or 100 nM) and OXB (1, 10 or 100 nM) with 1 µM of JNJ (OX2R antagonist). Read More

View Article
December 2018

Investigation of platelet-rich plasma in increasing proliferation and migration of endometrial mesenchymal stem cells and improving pregnancy outcome of patients with thin endometrium.

J Cell Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of Reproductive Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Background: Platelet-rich plasma (PRP) contains abundant growth factors and is gradually used in the field of reproduction. A thin endometrium is recognized as a critical factor in embryo implantation failure. Endometrial mesenchymal stem cells (EnMSCs), which were isolated from human menstrual blood, are highly proliferative and show multiple differentiation capacity. Read More

View Article
December 2018

Sectioning and extensively examining the fimbriated end (SEE-FIM) of the fallopian tube in routine practices, is it worth the effort?

J Obstet Gynaecol Res 2018 Dec 2. Epub 2018 Dec 2.

Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Aim: To determine the prevalence of fallopian tube high-grade serous carcinoma (HGSC) and to analyze the benefit of the sectioning and extensively examining the fimbriated end (SEE-FIM) protocol.

Methods: Fallopian tubes from 450 patients with risk-reducing salpingo-oophorectomy, or tumor of the ovary, endometrium, fallopian tube or peritoneum were examined using the SEE-FIM protocol. Microscopic tubal pathology and the number of paraffin blocks used were evaluated. Read More

View Article
December 2018

Long non-coding RNA AFAP1-AS1 promoting epithelial-mesenchymal transition of endometriosis is correlated with transcription factor ZEB1.

Am J Reprod Immunol 2018 Nov 30:e13074. Epub 2018 Nov 30.

First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China.

Problem: The role of the long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) in the etiology of endometriosis is unknown.

Method Of Study: Expression of epithelial-mesenchymal transition (EMT) markers was quantified using qRT-PCR, immunohistochemistry, and western blotting. The proliferation, migration, and invasion of ectopic endometrial epithelial cells and Ishikawa cells were evaluated by MTT, EdU, wound healing, and transwell assays. Read More

View Article
November 2018
1 Read

Uterine histopathological changes induced by acute administration of tamoxifen and its modulation by sex steroid hormones.

Toxicol Appl Pharmacol 2018 Nov 29;363:88-97. Epub 2018 Nov 29.

UCIBIO, REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Faculdade de Farmácia, University of Porto, Porto, Portugal.

The endometrium is a particular sensitive target tissue for estradiol that is able to promptly modify its structure. Tamoxifen (TAM), a selective estrogen receptor modulator, was shown to promote a spectrum of uterine abnormalities, though the morphological and stereological effects of this drug in uterus is not clear. In this way, we have used an established model of ovariectomy followed by estradiol benzoate (EB) or TAM treatment and analyzed their effects in uterine histopathology and proliferation. Read More

View Article
November 2018

Synthetic cannabinoids and endometrial stromal cell fate: dissimilar effects of JWH-122, UR-144 and WIN55,212-2.

Toxicology 2018 Nov 28. Epub 2018 Nov 28.

UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n.º 228, Porto, Portugal. Electronic address:

The emergence of synthetic cannabinoids (SCBs) as drugs of abuse in readily available "Spice" smoking blends has exposed users to much more potent cannabinoids than the phytocannabinoids present in Cannabis sativa L.. Increasing reports of adverse reactions are emerging in the clinical literature. Read More

View Article
November 2018

Endometrial but not Ovarian Response is Associated With Clinical Outcomes and can be Improved by Prolonged Pituitary Downregulation in Patients With Thin and Medium Endometrium.

Reprod Sci 2018 Dec 3:1933719118816835. Epub 2018 Dec 3.

1 Reproductive Medicine Centre, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, China.

The aim of this study is to investigate the effect of ovarian and endometrial response on live birth rates (LBRs) in young normal and high responders and prolonged pituitary downregulation on endometrial receptivity and clinical outcomes in patients with different endometrial thickness. Between January 2013 and December 2017, 9511 patients underwent first in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles with age ≤35 years, follicle stimulating hormone < 10 IU/l, and ≥4 retrieved oocytes were conducted. The estradiol (E) levels on the human chorionic gonadotropin (HCG) day were classified into 4 groups: group 1 (<3000 pg/mL); group 2 (3000-5000 pg/mL); group 3 (5000-7000 pg/mL), and group 4 (≥7000 pg/mL). Read More

View Article
December 2018

Primary Angiosarcoma of the Cervix: Case Report of a Rare Lesion.

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Royal Gwent Hospital, Newport (V.I.S., I.W.T.) Department of Pathology, University Hospital of Wales, Cardiff (G.L.R.) Department of Musculoskeletal Pathology, Royal Orthopaedic Hospital, Birmingham (V.P.S.) Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.), UK.

Angiosarcomas of the female genital tract are rare and primary angiosarcoma of the cervix is extremely rare with only one prior case report. We report a case of a primary cervical angiosarcoma in a 43-yr-old woman who presented with heavy vaginal bleeding. Cervical biopsy and subsequent radical hysterectomy showed a malignant vascular tumor which was composed of spindled and epithelioid cells and formed abortive vascular channels. Read More

View Article
December 2018
3 Reads

Performance Characteristics of Endometrial Sampling in Diagnosis of Endometrial Carcinoma.

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia (C.T., H.B., P.B.C., C.B.G.) Department of Laboratory Medicine and Pathobiology, University of Toronto (A.P.) Department of Laboratory Medicine Trillium Health Partners (A.P.) Department of Pathology, Health Sciences Center and University of Manitoba, Winnipeg, Manitoba (N.A.), Canada.

Outpatient endometrial biopsy can give false-negative results, with a 0.9% reported posttest probability for endometrial carcinoma (EC) after a negative result. Our objective was to determine if there has been any improvement in the performance characteristics of endometrial biopsy over the last 15 yr. Read More

View Article
December 2018
2 Reads

[COMPARISON OF ULTRASOUND INVESTIGATION METHODS IN POSTMENOPAUSE].

Georgian Med News 2018 Oct(283):19-26

Institute of Pediatrics, Obstetrics and Gynecology named E.M. Lukyanova of the NAS of Ukraine.

The aim of the study is to improve the diagnostic approach in assessing the state of the endometrium with the help of ultrasonic endometrial diagnostics in accordance with the IETА criteria in combination with three-dimensional Doppler indices, calculating the volume of the endometrium, and the 3D reconstruction in postmenopausal women. 167 postmenopausal women underwent a 2D pelvic ultrasound examination and a combined three-dimensional complex pelvic ultrasound examination that included calculation of the volume of the endometrium, three-dimensional dopplerometric indices (vascularization index, blood flow index and vascularization ratio), and 3D-reconstruction mode. In the second stage, the patients underwent hysteroscopy/endometrial bipyroscopy with morphological evaluation of tissue samples, which retrospectively performed analysis of echographic and dopplerometric criteria in patients with benign changes in the endometrium and their comparison with atrophic endometrium. Read More

View Article
October 2018

Stem cells and endometrial regeneration: from basic research to clinical trial.

Curr Stem Cell Res Ther 2018 Dec 5. Epub 2018 Dec 5.

Center for Reproductive Medicine, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing 210029, Jiangsu. China.

Monthly changes in the endometrial cycle indicate the presence of endometrial stem cells. In recent years, various stem cells that exist in the endometrium have been identified and characterized. Additionally, many studies have shown that bone marrow mesenchymal stem cells (BM-MSCs) provide an alternative source for regenerating the endometrium and repairing endometrial injury. Read More

View Article
December 2018

Impact of endometrial thickness during menstruation and endometrial scratching on the pregnancy in frozen-thawed embryo transfer.

J Obstet Gynaecol Res 2018 Dec 4. Epub 2018 Dec 4.

Department of Reproductive Medical Center, Guangdong Women and Children Hospital, Hospital of Guangzhou Medical University, Guangzhou, China.

Aim: This study aimed to investigate the impact of endometrial thickness (EMT) during menstruation and endometrial scratching on the pregnancy in frozen-thawed embryo transfer (FET).

Methods: About 1298 patients receiving FET were retrospectively analyzed and divided according to EMT on the 4th or 5th day of menstruation. Group A: EMT ≤ 3. Read More

View Article
December 2018

α-Parvin and β-parvin in the rat uterus during decidualisation and uterine receptivity.

Histochem Cell Biol 2018 Dec 5. Epub 2018 Dec 5.

Cell and Reproductive Biology Lab, Discipline of Anatomy and Histology, School of Medical Sciences, University of Sydney, Camperdown, Australia.

During early pregnancy, the uterine luminal epithelial cells (UECs) and endometrial stromal cells (ESCs) undergo morphological changes to enable blastocyst implantation. The present study investigates, for the first time, the cytoskeletal-associated proteins and α-actinin superfamily members, α-parvin and β-parvin, during early pregnancy in the rat uterus. These two PARVA proteins are involved in cell adhesion, morphological changes and regulation of other cytoskeletal proteins, through binding with proteins such as actin and integrin-linked kinase. Read More

View Article
December 2018

Impaired Localization of Claudin-11 in Endometriotic Epithelial Cells Compared to Endometrial Cells.

Reprod Sci 2018 Dec 4:1933719118811643. Epub 2018 Dec 4.

1 Department of Gynecology and Obstetrics, University of Giessen, Giessen, Germany.

Claudins are the major components of tight junctions and are often deregulated in human cancer, permitting escape of cancer cells along with the acquisition of invasive properties. Similarly, endometrial cells also show invasive capabilities; however, the role of tight junctions in endometriosis has only rarely been examined. In this study, we analyzed the protein expression and localization of claudin-7 and claudin-11 in human eutopic and ectopic endometrium and endometrial cell lines. Read More

View Article
December 2018

PAX2 in endometrial carcinogenesis and in differential diagnosis of endometrial hyperplasia. A systematic review and meta-analysis of diagnostic accuracy.

Acta Obstet Gynecol Scand 2018 Dec 4. Epub 2018 Dec 4.

Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.

Introduction: Benign and precancerous endometrial hyperplasias (EH) are differentiated according to two alternative histomorphologic classifications: World Health Organization (WHO) or Endometrial Intraepithelial Neoplasia (EIN) system. 2018 European Society of Gynaecological Oncology (ESGO) guidelines recommends paired box 2 protein (PAX2) immunohistochemistry to identify precancerous EH. However, methods for interpreting immunostaining and diagnostic accuracy are not defined, and the role of PAX2 in endometrial carcinogenesis is unclear. Read More

View Article
December 2018
2 Reads

Gynaecological cancers and leptin: A focus on the endometrium and ovary.

Facts Views Vis Obgyn 2018 Mar;10(1):5-18

Ovarian Cancer Laboratory, Veterans Affairs Medical Center, Kansas City, MO 64128, United States.

Obesity has an influence on the risk and prognosis of different types of cancers of the female reproductive tract. In the uterus, a common site for neoplasms is the endometrium, the inner lining tissue. Generally, obesity has been documented to be involved in endometrioid carcinoma of the endometrium. Read More

View Article
March 2018
3 Reads

Therapeutic Effects of VEGF Gene-Transfected BMSCs Transplantation on Thin Endometrium in the Rat Model.

Stem Cells Int 2018 30;2018:3069741. Epub 2018 Oct 30.

Reproductive Medicine Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Objective: Bone mesenchymal stem cells (BMSCs) transplantation has a therapeutic effect on the thin endometrium in animal researches and clinical trials. The present study aims at assessing whether transplantation of VEGF-transfected BMSCs (VEGF-BMSCs) have a better therapeutic effect on endometrial regeneration and endometrial receptivity compared with BMSCs therapy alone.

Methods: Sprague-Dawley (SD) rats were used in the study. Read More

View Article
October 2018

Primary squamous cell carcinoma of the endometrium in a woman of perimenopausal age: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13418

Department of Gynecology.

Rationale: Primary squamous cell carcinoma of the endometrium (PSCCE) is a rare entity, and only sporadic cases have been reported in the literature since the 1st report in 1892. This report describes a case of a perimenopausal woman with PSCCE.

Patient Concerns: A 47-year-old, human papilloma virus type 16-positive, perimenopausal woman was admitted to our hospital with irregular vaginal bleeding for 6 months and secondary anemia. Read More

View Article
November 2018

Expression of proinflammatory cytokines IL-1β, IL-6 and TNFα in the retained placenta of mares.

Theriogenology 2018 Nov 27;126:1-7. Epub 2018 Nov 27.

Department of Animal Reproduction with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn; Oczapowskiego 14; 10-719, Olsztyn; Poland.

Retained fetal membranes (RFM) is a prevalent postpartum disease in mares. During parturition, various proinflammatory cytokines are released in the placenta, which further facilitates uterine contractions, expulsion of the fetus and fetal membranes. We hypothesized that an altered inflammatory response in mares results in retained fetal membranes. Read More

View Article
November 2018
3 Reads

Estradiol promotes EMT in endometriosis via MALAT1/miR200s sponge function.

Reproduction 2018 Nov 1. Epub 2018 Nov 1.

L Zhang, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Endometriosis is an estrogen-dependent benign gynecological disease that shares some common features of malignancy. Epithelial-mesenchymal transition (EMT) has been recognized as a core mechanism of endometriosis. MALAT1 is widely known as EMT promoter, while miR200 family members (miR200s) are considered as EMT inhibitors. Read More

View Article
November 2018

Dimethyloxalylglycine preconditioning enhances protective effects of bone marrow-derived mesenchymal stem cells in Aβ- induced Alzheimer disease.

Physiol Behav 2018 Nov 27;199:265-272. Epub 2018 Nov 27.

Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Iran; Neurophysiology Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

Mesenchymal stem cell (MSC) transplantation therapy has been proposed as a promising approach for the treatment of neurodegenerative disease. Chemical and pharmacological preconditioning before transplantation could optimize the therapeutic properties of transplanted MSCs. In this study, we hypothesized that preconditioning treatment with a prolyl hydroxylase inhibitor, dimethyloxalylglycine (DMOG), will increase MSC efficacy and paracrine effects in an amyloid-β (Aβ)-injected Alzheimer rat model. Read More

View Article
November 2018

Decrease in pregnancy rate after endometrial scratch in women undergoing a first or second in vitro fertilization. A multicenter randomized controlled trial.

Hum Reprod 2018 Nov 29. Epub 2018 Nov 29.

CHU de Bordeaux, Endocrinology and Metabolism, Reproductive Medicine Unit, Bordeaux, France.

Study Question: Does endometrial scratch in women undergoing a first or second IVF/ICSI attempt improve the clinical pregnancy rate (CPR)?

Summary Answer: Endometrial scratch (ES) in women undergoing their first or second IVF/ICSI attempt does not enhance the CPR under the technical conditions of our study.

What Is Known Already: Several studies have suggested that physical scratch of the endometrium before an IVF attempt could improve embryo implantation.

Study Design, Size, Duration: This was a randomized controlled multi-center, two-arm, parallel trial. Read More

View Article
November 2018
2 Reads

Abnormally located SSEA1+/SOX9+ endometrial epithelial cells with a basalis-like phenotype in the eutopic functionalis layer may play a role in the pathogenesis of endometriosis.

Hum Reprod 2018 Nov 29. Epub 2018 Nov 29.

Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia.

Study Question: Is endometriosis associated with abnormally located endometrial basalis-like (SSEA1+/SOX9+) cells in the secretory phase functionalis and could they contribute to ectopic endometriotic lesion formation?

Summary Answer: Women with endometriosis had an abnormally higher number of basalis-like SSEA1+/SOX9+ epithelial cells present in the stratum functionalis and, since these cells formed 3D structures in vitro with phenotypic similarities to ectopic endometriotic lesions, they may generate ectopic lesions following retrograde menstruation.

What Is Known Already: Endometrial basalis cells with progenitor potential are postulated to play a role in the pathogenesis of endometriosis and SSEA1 and nuclear SOX9 (nSOX9) mark basalis epithelial cells that also have some adenogenic properties in vitro. Induction of ectopic endometriotic lesions in a baboon model of endometriosis produces characteristic changes in the eutopic endometrium. Read More

View Article
November 2018

A Combined Morphologic and Molecular Approach to Retrospectively Identify KRAS-Mutated Mesonephric-like Adenocarcinomas of the Endometrium.

Am J Surg Pathol 2018 Nov 27. Epub 2018 Nov 27.

Department of Pathology, Division of Women's and Perinatal Pathology.

An unusual subset of endometrial carcinoma, the mesonephric-like adenocarcinomas, are morphologically and molecularly similar to mesonephric carcinoma, characterized by KRAS mutation and lack of microsatellite instability. They also have a unique immunohistochemical profile and are usually positive for GATA-3, CD10, TTF-1, and negative for ER and PR. This study implemented a combined morphologic and molecular approach to retrospectively identify mesonephric-like carcinomas of the endometrium. Read More

View Article
November 2018

To evaluate immunoreactivity of cyclooxygenase-2 in cases of endometrial carcinoma and correlate it with expression of p53 and vascular endothelial growth factor.

J Cancer Res Ther 2018 Oct-Dec;14(6):1366-1372

Department of Radiation Oncology, Army Hospital (R & R), New Delhi, India.

Context: Increased levels of prostaglandins have been detected in cancers of several anatomic sites, including those of endometrium. Several studies have shown that cyclooxygenase-2 (COX-2) expression is aberrantly increased in various human epithelial cancers, and cellular up-regulation of COX-2 may be a common mechanism in epithelial carcinogenesis.

Aims: To examine the expressions of COX-2, p53 and vascular endothelial growth factor (VEGF) in endometrial cancer and their relationships with clinicopathologic characteristics. Read More

View Article
November 2018
3 Reads

Dosimetric comparison of bladder, rectal, and vaginal surface doses between ovoids and cylinder-based vaginal brachytherapy in carcinoma of the endometrium.

J Cancer Res Ther 2018 Oct-Dec;14(6):1191-1195

Division of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

Purpose: The study aims to estimate the differences in vaginal surface, bladder, and rectal doses when adjuvant intracavitary brachytherapy is carried out with ovoids or with vaginal cylinders, in postoperative carcinoma endometrium and to assess the difference in variability in organs at risk (OAR) doses and thereby the reproducibility of application in subsequent sittings.

Materials And Methods: Fifteen patients each received vaginal brachytherapy with ovoid and cylindrical applicators. The dose received by 0. Read More

View Article
November 2018
3 Reads

Integrated Eutopic Endometrium and Non-Depleted Serum Quantitative Proteomic Analysis Identifies Candidate Serological Markers of Endometriosis.

Proteomics Clin Appl 2018 Nov 28:e1800153. Epub 2018 Nov 28.

Human Development and Health, University of Southampton, Southampton, SO16, UK.

Background: Endometriosis affects about 4% of women in the reproductive age and is associated with subfertility. The aim of the present study is to examine the integrated quantitative proteomic profile of eutopic endometrium and serum from women with endometriosis compared to controls in order to identify candidate disease-specific serological markers.

Methods: Eutopic endometrium and serum from patients with endometriosis (n = 8 for tissue and n = 4 for serum) are, respectively, compared to endometrium and serum from females without endometriosis (n = 8 for tissue and n = 4 for serum) using a shotgun quantitative proteomics method. Read More

View Article
November 2018
2.680 Impact Factor

Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375.

Int J Mol Sci 2018 Nov 28;19(12). Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, 50090 Tartu, Estonia.

microRNA (miRNA) expression level alterations between endometrial tissue and endometriotic lesions indicate their involvement in endometriosis pathogenesis. However, as both endometrium and endometriotic lesions consist of different cell types in various proportions, it is not clear which cells contribute to variability in miRNA levels and the overall knowledge about cell-type specific miRNA expression in ectopic cells is scarce. Therefore, we utilized fluorescence-activated cell sorting to isolate endometrial stromal cells from paired endometrial and endometrioma biopsies and combined it with high-throughput sequencing to determine miRNA alterations in endometriotic stroma. Read More

View Article
November 2018

Increased Expression Levels of Metalloprotease, Tissue Inhibitor of Metalloprotease, Metallothionein, and p63 in Ectopic Endometrium: An Animal Experimental Study.

Rev Bras Ginecol Obstet 2018 Nov 28;40(11):705-712. Epub 2018 Nov 28.

Faculty of Medicine, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

Objective:  To characterize the patterns of cell differentiation, proliferation, and tissue invasion in eutopic and ectopic endometrium of rabbits with induced endometriotic lesions via a well- known experimental model, 4 and 8 weeks after the endometrial implantation procedure.

Methods:  Twenty-nine female New Zealand rabbits underwent laparotomy for endometriosis induction through the resection of one uterine horn, isolation of the endometrium, and fixation of tissue segment to the pelvic peritoneum. Two groups of animals (one with 14 animals, and the other with15) were sacrificed 4 and 8 weeks after endometriosis induction. Read More

View Article
November 2018
1 Read

Moving from peripheral blood to local uterine immunophenotype analysis in patients with poor reproductive history: pilot study of a novel technique.

Ir J Med Sci 2018 Nov 27. Epub 2018 Nov 27.

Sims IVF Clinic, Clonskeagh Road, Clonskeagh, Dublin 14, Ireland.

Background: A complete reproductive immunophenotype is poorly described, with most focus on peripheral blood natural killer cells rather than uterine populations. There is debate regarding normal endometrial levels, with no consensus, and much controversy on correlation with implantation/miscarriage.

Aims: Development and validation of a rapid endometrial assessment flow cytometry (FCM) technique, allowing determination of local lymphocyte subset ranges, comparison to peripheral blood, and patient subgroup analysis. Read More

View Article
November 2018

Identification of long non‑coding RNA expression patterns useful for molecular‑based classification of type I endometrial cancers.

Oncol Rep 2018 Nov 21. Epub 2018 Nov 21.

Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ῾Scuola Medica Salernitana᾽, University of Salerno, I‑84081 Baronissi (SA), Italy.

Endometrial cancer is the most frequently diagnosed gynecologic malignant disease. Although several genetic alterations have been associated with the increased risk of endometrial cancer, to date, the diagnosis and prognosis still rely on morphological features of the tumor, such as histological type, grading and invasiveness. As molecular‑based classification is desirable for optimal treatment and prognosis of these cancers, we explored the potential of lncRNAs as molecular biomarkers. Read More

View Article
November 2018
4 Reads

Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine Environment.

Front Immunol 2018 13;9:2597. Epub 2018 Nov 13.

Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria.

During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is critical for adapting blood flow and nutrient transport to the developing fetus. Failures in this process have been noticed in different pregnancy complications such as preeclampsia, intrauterine growth restriction, stillbirth, or recurrent abortion. Read More

View Article
November 2018

Dysregulation of Krüppel-like factor 12 in the development of endometrial cancer.

Gynecol Oncol 2018 Oct 25. Epub 2018 Oct 25.

Department of Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, People's Republic of China.. Electronic address:

Objective: Endometrial cancer (EC) remains a malignancy with poor survival outcome. To investigate the role of Krüppel-like factor 12 (KLF12), a transcription factor, in the progression of human EC.

Methods: Immunohistochemistry, real time-PCR and western blot analysis of KLF12 expression in EC patients' tissues. Read More

View Article
October 2018
3 Reads

A family with PTEN mutations with malignancy and an unusually high number of offspring with autism spectrum disorder: a case report.

J Med Case Rep 2018 Nov 28;12(1):353. Epub 2018 Nov 28.

Institute of Cardiovascular Research, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK.

Background: Cowden's syndrome (OMIM:158350), a rare genetic disorder (incidence ~ 1:250,000), is caused by mutations of the tumor suppressor gene PTEN. In this report, we describe clinical manifestations of a 56-year-old patient diagnosed with Cowden's syndrome and his family with PTEN mutations. The family has an unusually high number of offspring with autism spectrum disorder. Read More

View Article
November 2018
1 Read

Multiple Myeloma 1 Transcription Factor Is Superior to CD138 as a Marker of Plasma Cells in Endometrium.

Int J Surg Pathol 2018 Nov 28:1066896918814307. Epub 2018 Nov 28.

1 University of California, Los Angeles, CA, USA.

Chronic endometritis is characterized by plasma cell (PC) infiltration of endometrial stroma. Identification of PCs can be challenging by routine hematoxylin and eosin (H&E) stain due to the low numbers of PCs or to their being obscured by other cells in the stroma. CD138 is widely used as an ancillary immunohistochemistry stain to identify PCs; however, it has a high background reaction. Read More

View Article
November 2018
1 Read

Abnormal uterine bleeding in adolescents: ultrasound evaluation of uterine volume.

Gynecol Endocrinol 2018 Nov 27:1-4. Epub 2018 Nov 27.

b Second Faculty of Medicine, Medical University of Warsaw , Warsaw , Poland.

Objective: To evaluate ultrasonographic measurements of internal genitalia in girls suffering from abnormal uterine bleeding (AUB) and to compare the appearances with those of healthy girls. DESIGN Prospective case - control study.

Methods: One hundred and five not sexually active adolescent girls were enrolled - 67 patients were suffering from AUB and there were 38 healthy peers. Read More

View Article
November 2018

Transitional cell carcinoma of endometrium: a case report of rare pure form.

J Contemp Brachytherapy 2018 Oct 31;10(5):483-485. Epub 2018 Oct 31.

Radiotherapy Unit ARNAS-Civico Palermo.

Transitional cell carcinoma is a very rare histological subtype of endometrial cancer, with only 18 cases described in literature. Ovary represents the most common site where it accounts for 2% of all ovarian cancers. Due to the rarity of this disease, current management is controversial and includes various approaches, mostly described in the adjuvant setting, both radiotherapy and chemotherapy alone or in combination. Read More

View Article
October 2018
4 Reads

The Influence of Hen Aging on Eggshell Ultrastructure and Shell Mineral Components.

Korean J Food Sci Anim Resour 2018 Oct 31;38(5):1080-1091. Epub 2018 Oct 31.

Department of Animal Science and Biotechnology, Gyeongnam National University of Science and Technology, Jinju 52725, Korea.

The eggshell, which is a complex and highly ordered structure, is very important factor for food safety and egg marketing. This study investigated the changes in eggshell structure and shell components in relationship to hen age. For this study, we examined the histological change of the endometrium of the 30-, 60-, and 72-wk-old commercial layers, and analyzed the ultrastructure and ionic composition of their eggshells. Read More

View Article
October 2018

The in vitro effect of progesterone on the orexin system in porcine uterine tissues during early pregnancy.

Acta Vet Scand 2018 Nov 26;60(1):76. Epub 2018 Nov 26.

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719, Olsztyn-Kortowo, Poland.

Background: Orexin A (OXA) and orexin B (OXB) are hypothalamic-derived peptides that participate in the regulation of energy metabolism, food intake and reproductive function by influencing the hypothalamic-pituitary-ovarian axis. Orexins are also produced in the endometrium, myometrium and placenta, which suggests that they could act as a link between energy metabolism and the reproductive system. Changes in the expression of orexin and the orexin receptor genes and proteins during the oestrous cycle and early gestation in pigs imply that orexin activity may be regulated by local factors within the uterus. Read More

View Article
November 2018

A Two-Cohort RNA-seq Study Reveals Changes in Endometrial and Blood miRNome in Fertile and Infertile Women.

Genes (Basel) 2018 Nov 23;9(12). Epub 2018 Nov 23.

Competence Centre on Health Technologies, 50410 Tartu, Estonia.

The endometrium undergoes extensive changes to prepare for embryo implantation and microRNAs (miRNAs) have been described as playing a significant role in the regulation of endometrial receptivity. However, there is no consensus about the miRNAs involved in mid-secretory endometrial functions. We analysed the complete endometrial miRNome from early secretory (pre-receptive) and mid-secretory (receptive) phases from fertile women and from patients with recurrent implantation failure (RIF) to reveal differentially expressed (DE) miRNAs in the mid-secretory endometrium. Read More

View Article
November 2018
8 Reads

Multidimensional Effects of Soy Isoflavone by Food or Supplements in Menopause Women: a Systematic Review and Bibliometric Analysis.

Nat Prod Commun 2016 Nov;11(11):1733-1740

Isoflavones can exert their action on various levels: on cardiovascular system, bone and muscle health, on cancer, on menopausal symptoms, on obesity, on thyroid and on cognitive function. The aim of this systematic review is to evaluate the multidimensional effects of phytoestrogens in postmenopausal woman, and specifically to explore the impact on scientific literature. A research strategy was planned on PubMed and Scopus by defining the following key words:: menopause, climacteric, soy, isoflavone, phytoestrogens, cardiovascular system, bone mineral density, muscle mass, cancer, thyroid, obesity, cognitive. Read More

View Article
November 2016
1 Read

Early luteal phase progestin concentration influences endometrial function in pregnant mares.

Theriogenology 2018 Nov 19;125:236-241. Epub 2018 Nov 19.

Platform Artificial Insemination and Embryo Transfer, Department for Small Animals and Horses, Vetmeduni Vienna, Veterinärplatz 1, 1210, Vienna, Austria. Electronic address:

In the horse, it is still unclear if and to what extent low progestin concentration contributes to early conceptus loss. In the present study, we have investigated if reduced or elevated progestin concentration in the early luteal phase influences endometrial function and conceptus development. We hypothesized that reduced progestin concentration via delayed downregulation of endometrial progesterone receptors (PR) influences endometrial function in healthy fertile mares while progestin substitution does not. Read More

View Article
November 2018

Precaval positive sentinel lymph node with bilateral negative pelvic sentinel lymph node in low-risk endometrial cancer patient.

J Gynecol Obstet Hum Reprod 2018 Nov 23. Epub 2018 Nov 23.

Gynecologic and Breast Oncologic Surgery Department, European Georges Pompidou Hospital, 20, rue Leblanc, 75908 Paris Cedex 15, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.

We here describe a case report of a positive precaval sentinel lymph node with negative pelvic sentinel lymph node in a patient with endometrial cancer. A 45-years-old woman was diagnosed with a grade 2 endometrioid carcinoma of the endometrium. She was treated with a hysterectomy and bilateral salpingo-oophorectomy, associated with dissection of sentinel lymph nodes (SLNs). Read More

View Article
November 2018
1 Read

Porous Scaffolds from Droplet Microfluidics for Prevention of Intrauterine Adhesion.

Acta Biomater 2018 Nov 23. Epub 2018 Nov 23.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. Electronic address:

Severe intrauterine adhesions (IUAs) have a great negative impact on women's psychological and reproductive health. It remains a significant challenge to prevent postoperative IUAs because of the complications of various clinical preventive measures and incompatibility of uterine cavity morphology. Herein, we present a new drug-loadedporous scaffoldbased on a microfluidic droplet template, which combines the characteristics of the artificial biocompatible material GelMA and the natural polysaccharide material Na-alginate. Read More

View Article
November 2018
6 Reads

Cervico-vaginal secretion cytokine profile: A non-invasive approach to study the endometrial receptivity in IVF cycles.

Am J Reprod Immunol 2018 Nov 26:e13064. Epub 2018 Nov 26.

Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.

Problem: Cytokines have a significant role in the process of embryo implantation, trophoblast growth, and differentiation by modulating the immune and endocrine system. The aim of this study was to investigate the profile of a large set of cytokines in the cervico-vaginal washing of women undergoing IVF, to explore the association of these proteins with a good receptive endometrium.

Method Of Study: A cohort of 155 women scheduled for IVF cycle was recruited. Read More

View Article
November 2018
7 Reads