35,026 results match your criteria Endometrium Carcinoma


Low-Grade Endometrial Stromal Sarcoma Diagnosed 8 Years After Hysterectomy With Morcellation.

Obstet Gynecol 2020 Jul 9. Epub 2020 Jul 9.

Johns Hopkins University School of Medicine, the Division of Gynecologic Pathology, Department of Pathology, Johns Hopkins Medicine, and the Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, Maryland.

Background: Morcellation at the time of minimally invasive hysterectomy or myomectomy for presumed benign indications carries a risk of disseminating undiagnosed uterine malignancies.

Case: A 57-year-old woman with a remote history of laparoscopic hysterectomy with morcellation of a cellular leiomyoma presented with a newly diagnosed complex pelvic mass. Owing to adherence of the mass to the rectum and numerous peritoneal tumor implants, a surgical cytoreductive procedure was performed. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003908DOI Listing

The use of hysteroscopy in endometrial cancer: old questions and novel challenges.

Climacteric 2020 Aug;23(4):330-335

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Endometrial cancer is the most common gynecological malignancy with a relatively good overall prognosis. It traditionally has two subtypes: type 1 (endometrioid carcinoma) and type 2 (non-endometrioid carcinoma). The prognosis is excellent for stage I endometrioid cancer, with a 5-year survival rate of 96%. Read More

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http://dx.doi.org/10.1080/13697137.2020.1732914DOI Listing

Positive peritoneal cytology is an independent risk factor in endometrial cancer.

J Obstet Gynaecol Res 2020 Jul 8. Epub 2020 Jul 8.

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.

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http://dx.doi.org/10.1111/jog.14361DOI Listing

Renal Hemangioblastoma with Mixed Mullerian tumour of endometrium: A tale of two rare primary tumours.

World J Surg Oncol 2020 Jul 6;18(1):154. Epub 2020 Jul 6.

Department of Pathology, Maulana Azad Medical College, New Delhi, India.

Introduction: Renal hemangioblastoma (RH) is a very rare benign tumour. Hemangioblastoma most commonly occurs in the central nervous system (CNS), and only few cases of RH have been reported as they occur most commonly as asymptomatic masses found incidentally. Mixed Mullerian tumour (MMT) of the uterus is a rarer and aggressive form of uterine malignancy. Read More

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http://dx.doi.org/10.1186/s12957-020-01929-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339407PMC

Performing gynecologic cancer surgery during the COVID-19 pandemic in Turkey: A multicenter retrospective observational study.

Int J Gynaecol Obstet 2020 Jul 4. Epub 2020 Jul 4.

Medeniyet University, Department of Obstetrics and Gynecology, Gynecologic Oncology Division, Istanbul, Turkey.

Objective: To report the perioperative outcomes of 200 patients with gynecologic cancer who underwent surgery during the Novel Coronavirus Disease (COVID-19) pandemic and the safety of surgical approach.

Methods: Data of patients operated between March 10 and May 20, 2020, were collected retrospectively. Data were statistically analyzed using IBM Statistical Package for the Social Sciences (SPSS) Statistics for Windows v. Read More

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http://dx.doi.org/10.1002/ijgo.13296DOI Listing

Pembrolizumab and Radiotherapy for Platinum-refractory Recurrent Uterine Carcinosarcoma With an Abscopal Effect: A Case Report.

Anticancer Res 2020 Jul;40(7):4131-4135

Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan.

Background: Immune responses due to radiotherapy and immune checkpoint inhibitors potentially have synergistic effects.

Case Report: Here, we report a 65-year-old Japanese woman presenting with high-grade endometrial cancer. She was diagnosed with carcinosarcoma, stage IB. Read More

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http://dx.doi.org/10.21873/anticanres.14412DOI Listing

Hysterectomy and Oophorectomy in Reproductive Age: A Cross-Sectional Study from a Tertiary Care Hospital.

Cureus 2020 May 28;12(5):e8344. Epub 2020 May 28.

Pathology, Dow Medical College, Dow University of Health Sciences, Karachi, PAK.

Introduction Hysterectomy is a common surgical procedure in women, and oophorectomy may also be performed with the hysterectomy. The objective of this study was to identify clinical indications and pathological findings in hysterectomies, performed for gynecological causes, in women of reproductive age (15-49 years) and to determine if oophorectomy or ovarian conservation was performed with the hysterectomy as well as the pathological findings in the ovaries. Methods This cross-sectional study was conducted in the department of Pathology at Dow Medical College in Karachi, Pakistan, from September 2017 to December 2018. Read More

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http://dx.doi.org/10.7759/cureus.8344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325352PMC

Endometriosis-Associated Ovarian Cancer: The Origin and Targeted Therapy.

Cancers (Basel) 2020 Jun 24;12(6). Epub 2020 Jun 24.

Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589-8511, Japan.

Endometrial cysts (ECs) are thought to be the origin of endometriosis-associated ovarian cancer (EAOC). A hypothesis that the oxidative stress of iron in cysts causes "malignant transformation of ECs" has been proposed, but this has not been verified. Several population-based studies showed that endometriosis was a risk factor but did not reflect the "malignant transformation of ECs". Read More

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http://dx.doi.org/10.3390/cancers12061676DOI Listing

HISTOPATHOLOGIC FINDINGS IN WOMEN UNDERGOING HYSTEROSCOPIC RESECTION OF ENDOMETRIAL POLYPS AND UTERINE MYOMAS.

Acta Clin Croat 2019 Dec;58(4):627-631

1Department of Gynecology and Obstetrics, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2School of Medicine, University of Rijeka, Rijeka, Croatia; 3Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.

The aim of our study was to determine the prevalence of endometrial premalignant and malignant lesions in women undergoing hysteroscopy and to identify anthropologic factors related to the presence of malignancy. Data on 3470 women with submucosal myomas or endometrial polyps suspected on ultrasound were retrospectively analyzed. Hysteroscopy was performed in all these women in order to make a more precise diagnosis. Read More

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http://dx.doi.org/10.20471/acc.2019.58.04.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314300PMC
December 2019

Atypical polypoid adenomyoma follow-up and management: Systematic review of case reports and series and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(26):e20491

Clinic of Obstetrics and Gynecology, DINOGMI, IRCCS San Martino Hospital, University of Genova, Genova (GE), Italy.

Background: Atypical polypoid adenomyoma (APA) is a rare uterine tumor typically found in fertile age and associated with infertility. Among young nullipara women, conservative treatment is proposed despite the high recurrence rate and the association with endometrial cancer.Our aim was to assess the risk of recurrence with different conservative treatments in fertile ages and the prevalence of malignant or pre-malignant associated lesions to better address an adequate patient counselling when treatment modalities are discussed. Read More

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http://dx.doi.org/10.1097/MD.0000000000020491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328951PMC

A case of endometrial carcinoma progressed during pregnancy resulting in fetal death.

Int Cancer Conf J 2020 Jul 22;9(3):159-161. Epub 2020 May 22.

Department of Gynecology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31, Koto-ku, Ariake, Tokyo, 135-8550 Japan.

Most endometrial carcinomas (ECs) occurring during pregnancy are diagnosed in the first trimester. During the gestation period, progesterone level, which has a protective effect on the endometrium, is found to increase. In EC cases, administering high-dose progesterone is a therapeutic strategy because this hormone can considerably shrink tumors. Read More

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http://dx.doi.org/10.1007/s13691-020-00417-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297887PMC

Clinicopathologic features of endometrial cancer with mismatch repair deficiency.

Ecancermedicalscience 2020 18;14:1061. Epub 2020 Jun 18.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA.

The inclusion of DNA mismatch repair (MMR) evaluation as a standard of care for endometrial cancer management will result in a growing population of patients with MMR deficiency and negative germline Lynch syndrome testing (MMR-deficient). In this systematic review and study, the clinicopathologic features of endometrial cancer in patients with MMR-intact, MLH1 methylation positive, MMR-deficient or Lynch syndrome are evaluated. A systematic search of online databases between 1990 and 2018 identified studies of endometrial cancer patients with tumour testing (MMR protein immunohistochemistry or microsatellite instability) and germline assessment for Lynch syndrome. Read More

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http://dx.doi.org/10.3332/ecancer.2020.1061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302890PMC

Case report of large malignant pericardial effusion in a post-surgical setting of endometrial mixed carcinoma: A description of unique cytological, histological, and immunohistochemical findings.

SAGE Open Med Case Rep 2020 10;8:2050313X20930919. Epub 2020 Jun 10.

Department of Pathology, Kanazawa Medical University Hospital, Ishikawa, Japan.

Appearance of endometrial carcinoma in pericardial effusion is extremely rare. Its major etiological factors include lung cancer, breast cancer, lymphoma, and leukemia. We herein report a case of a large malignant pericardial effusion 7 years after surgery for endometrial carcinoma. Read More

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http://dx.doi.org/10.1177/2050313X20930919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290248PMC

The Many Faces of Endometriosis-Related Neoplasms in the Same Patient: A Brief Report.

Gynecol Obstet Invest 2020 Jun 22:1-6. Epub 2020 Jun 22.

Unità di Gineco-Patologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy,

Introduction: Endometriosis is a common benign gynecological condition that can be associated with a slightly increased risk of developing a wide range of malignancies.

Case Presentation: We herein report a singular case of a 62-year-old woman with a history of pelvic endometriosis, referred to our institution for chronic pelvic pain and uterine bleeding, with clinical and radiological evidence of left ovarian mass of 18 cm in largest diameter and multiple nodular mural lesions of the uterine cavity. The patient underwent exploratory laparotomy followed by hysterectomy, bilateral salpingo-oophorectomy, and omentectomy with pelvic lymph-node sampling. Read More

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http://dx.doi.org/10.1159/000508225DOI Listing

Laparoscopic complete resection of bulky precaval nodes by extraperitoneal approach in a patient with advanced endometrial cancer.

Int J Gynecol Cancer 2020 Jun 21. Epub 2020 Jun 21.

Gynecology and Obstetrics Department, Hospital Universitario Donostia, San Sebastian, Spain.

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http://dx.doi.org/10.1136/ijgc-2019-001083DOI Listing

[Coronavirus disease (COVID-19) and sirtuins].

Rev Fac Cien Med Univ Nac Cordoba 2020 06 16;77(2):117-125. Epub 2020 Jun 16.

Laboratorio de Biotecnología Celular y Molecular Avanzada (LAB-BIOTCEMA), Universidad Nacional de San Agustìn, Arequipa Perù.

Introduction: The NAD+dependent proteins deacetylases are called Sirtuins (SIRT).

Objectives: Objectives: this review is to study the sirtuins involved in cancer, as well as SIRT1 inhibition studies in patients with coronavirus disease COVID-19.

Data Source And Selection: For this, a search was made in Medline, Scopus and WOS, where descriptive studies of each of the functions of sirtuins were included, adjusted to recent scientific research. Read More

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http://dx.doi.org/10.31053/1853.0605.v77.n2.28196DOI Listing

Surgical Approach to Abdominal Tumors Involving the Inferior Vena Cava.

Isr Med Assoc J 2020 Jun;22(6):364-368

Department of Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Abdominal tumors invading the inferior vena cava (IVC) present significant challenges to surgeons and oncologists.

Objectives: To describe a surgical approach and patient outcomes.

Methods: The authors conducted a retrospective analysis of surgically resected tumors with IVC involvement by direct tumor encasement or intravascular tumor growth. Read More

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Programmed Death Ligand 1: A Poor Prognostic Marker in Endometrial Carcinoma.

Diagnostics (Basel) 2020 Jun 11;10(6). Epub 2020 Jun 11.

Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur 56000, Malaysia.

Endometrial carcinoma is the only gynaecologic malignancy with a raising incidence and mortality, posing a major health concern worldwide. The upregulation of programmed death ligand 1 (PD-L1) on tumour cells causes T-cell suppression, which impedes antitumour immunity, promotes immune cell evasion and enhances tumour survival. The aim of this study was to evaluate PD-L1 expression in endometrial carcinoma and to correlate it with survival rate. Read More

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http://dx.doi.org/10.3390/diagnostics10060394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345287PMC

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial.

Lancet 2020 06;395(10240):1855-1863

Division of Haematology and Immunology, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.

Background: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group reported long-term cancer outcomes (mean follow-up 55·7 months [SD 31·4]) for participants with Lynch syndrome enrolled into a randomised trial of daily aspirin versus placebo. This report completes the planned 10-year follow-up to allow a longer-term assessment of the effect of taking regular aspirin in this high-risk population. Read More

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http://dx.doi.org/10.1016/S0140-6736(20)30366-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294238PMC

Is the finding of endometrial hyperplasia or corporal polyp an mandatory indication for biopsy?

Ceska Gynekol 2020 ;85(2):84-93

Objective: The aim of our study was to analyze a group of patients referred for endometrial biopsy. To evaluate the ultrasound finding of hyperplasia/polyp, the symptomatology of patients related to the result of definitive histology, to determine the severity of individual variables in connection with the detection of precancerosis/cancer. Due to the complexity of information identify women who are suitable for conservative approach. Read More

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Alternative management for gynecological cancer care during the COVID-2019 pandemic: A Latin American survey.

Int J Gynaecol Obstet 2020 Jun 11. Epub 2020 Jun 11.

Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Bogotá, Colombia.

Objective: To determine the acceptance rate of treatment alternatives for women with either preinvasive conditions or gynecologic cancers during the COVID-19 pandemic among Latin American gynecological cancer specialists.

Methods: Twelve experts in gynecological cancer designed an electronic survey, according to recommendations from international societies, using an online platform. The survey included 22 questions on five topics: consultation care, preinvasive cervical pathology, and cervical, ovarian, and endometrial cancer. Read More

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http://dx.doi.org/10.1002/ijgo.13272DOI Listing

Diagnostic value of microRNA panel in endometrial cancer: A systematic review.

Oncotarget 2020 May 26;11(21):2010-2023. Epub 2020 May 26.

Royal Cornwall Hospital NHS Trust, Truro, Cornwall, United Kingdom.

Purpose: We conducted a systematic review to evaluate the overall diagnostic accuracy of miRNAs in detecting endometrial cancer.

Materials And Methods: A systematic search of Medline, Embase, Cinahl and the Cochrane Controlled Register of Trials was performed to identify studies reporting on the diagnostic value of miRNA in EC patients. Included were diagnostic studies looking at miRNA expression in women diagnosed with endometrial cancer. Read More

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http://dx.doi.org/10.18632/oncotarget.27601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260115PMC

Molecular and biological profile may discriminate between synchronous or metachronous endometrial and ovarian cancer.

Int J Gynecol Cancer 2020 Jul 9;30(7):1071-1076. Epub 2020 Jun 9.

Dipartimento Scienze della vita e sanità pubblica, Università Cattolica del Sacro Cuore, Rome, Italy, Rome, Italy

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http://dx.doi.org/10.1136/ijgc-2020-001545DOI Listing

Patient-initiated follow-up for low-risk endometrial cancer: a cost-analysis evaluation.

Int J Gynecol Cancer 2020 Jul 9;30(7):1000-1004. Epub 2020 Jun 9.

Department of Gynaecological Oncology, University Hospitals of Leicester NHS Trust, Leicester, UK

Objective: Risk stratification has resulted in patient-initiated follow-up being introduced for low-risk endometrial cancer in place of routine hospital follow-up. The financial benefit to the patient and the healthcare economy of patient-initiated follow-up, as compared with hospital follow-up, has yet to be explored. In this study, we explored the potential impact for both the healthcare economy and patients of patient-initiated follow-up. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001074DOI Listing

An overview of the main intrauterine pathologies in the postmenopausal period.

Authors:
R Manchanda S Thapa

Climacteric 2020 Aug 10;23(4):384-387. Epub 2020 Jun 10.

Gynaecological Endoscopy, Rosewalk Hospital, New Delhi, India.

Hysteroscopy is the gold standard for evaluating the uterine cavity, diagnosing intrauterine pathology, and operative intervention for some causes of abnormal uterine bleeding. The American College of Obstetricians and Gynecologists concluded that, when the endometrium measures ≤4 mm with transvaginal ultrasonography, the likelihood that bleeding is secondary to endometrial carcinoma is less than 1% (negative predictive value 99%), and endometrial biopsy is not recommended. Endometrial sampling in this clinical scenario will likely result in insufficient tissue for evaluation and it is reasonable to consider initial management for atrophy. Read More

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http://dx.doi.org/10.1080/13697137.2020.1776694DOI Listing

Detection of microsatellite instability in a panel of solid tumours with the Idylla MSI Test using extracted DNA.

J Clin Pathol 2020 Jun 8. Epub 2020 Jun 8.

Department of Pathology, CHU Henri Mondor, Créteil, France

Aim: During the last few years, determination of microstatellite instability (MSI) status has become a routine part of clinical practice, essentially to detect Lynch syndrome. Recently, MSI testing has increased with the development of immunotherapy and has expanded to a large panel of solid tumours. The aim of our work was to evaluate a fully automated system developed by Biocartis, the Idylla MSI Test, which performs an MSI analysis within 150 min. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206581DOI Listing

Hysteroscopic resectoscope-directed biopsies and outpatient endometrial sampling for assessment of tumor histology in women with endometrial cancer or atypical hyperplasia.

Eur J Obstet Gynecol Reprod Biol 2020 Aug 11;251:173-179. Epub 2020 May 11.

Gynecology and Obstetrics, Copenhagen University Hospital, Copenhagen, Denmark.

Objective: To evaluate and compare the diagnostic efficiency of outpatient endometrial sampling (OES) and hysteroscopic resectoscope-directed biopsies (HY) to distinguish between endometrial cancer (EC) and atypical hyperplasia (AH) and to assess tumor type and grade (histotype) in women with EC.

Design: Patients with AH or EC (n = 266) among 1013 patients consecutively referred because of postmenopausal bleeding were included. Identification of EC versus AH, and unfavorable tumor types (endometrioid grade 3 or non-endometrioid tumors) using OES and HY was compared to final histopathology at hysterectomy. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.010DOI Listing

Incisional carcinoma of Mullerian Origin: A case report and review of literature.

Gynecol Oncol Rep 2020 Aug 22;33:100588. Epub 2020 May 22.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, MN, United States.

Primary incisional carcinoma (PIC) is a rare, delayed complication of surgery, usually attributed to the malignant transformation of endometriosis. We report a case of incisional carcinoma with nodal metastases in a 55-year-old woman, 18 years after cesarean section. She underwent extirpative surgery, including hysterectomy and bilateral salpingo-oophorectomy, without intraperitoneal disease identifed. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262414PMC

Surgical Conservative Treatment for Endometrial Cancer in Women of Reproductive Age: Incidence of Urinary Tract Symptoms.

Anticancer Res 2020 Jun;40(6):3065-3069

First Department of Surgery, Laiko General Hospital, National and Kapodistrian University of Athens, Athens, Greece

Endometrial cancer is the most common gynecologic malignancy. The mainstay of treatment for endometrial cancer is total hysterectomy with bilateral salpingo-oophorectomy. Radiation and chemotherapy accompanied with progestins can also play a significant role in treatment. Read More

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http://dx.doi.org/10.21873/anticanres.14287DOI Listing

Executive summary of the American Radium Society® Appropriate Use Criteria for management of uterine carcinosarcoma.

Gynecol Oncol 2020 May 29. Epub 2020 May 29.

Stritch School of Medicine, Loyola University Chicago, IL, United States of America.

Objective: Uterine carcinosarcomas (UCS) represent a rare but aggressive subset of endometrial cancers, comprising <5% of uterine malignancies. To date, limited prospective trials exist from which evidence-based management of this rare malignancy can be developed.

Methods: The American Radium Society Appropriate Use Criteria presented in this manuscript are evidence-based guidelines developed by a multidisciplinary expert panel for management of women with UCS. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.04.683DOI Listing

Combination of sentinel lymph node mapping and uterine frozen section examination to reduce side-specific lymphadenectomy rate in endometrial cancer: a Turkish Gynecologic Oncology Group study (TRSGO-SLN-002).

Int J Gynecol Cancer 2020 Jul 30;30(7):1005-1011. Epub 2020 May 30.

Obstetrics and Gynecology, Koc University School of Medicine, Istanbul, Turkey.

Objective: This study aimed to find out whether side-specific pelvic lymphadenectomy can be omitted without compromising diagnostic efficacy according to "reflex frozen section" analysis of the uterus in case of sentinel lymph node (SLN) mapping failure.

Methods: Patients who underwent surgery for endometrial cancer with an SLN algorithm were stratified as low-risk or high-risk according to the uterine features on the final pathology reports. Two models for low-risk patients were defined to omit side-specific pelvic lymphadenectomy: strategy A included patients with endometrioid histology, grade 1-2, and <50% myometrial invasion irrespective of the tumor diameter; strategy B included all factors of strategy A with the addition of tumor diameter ≤2 cm. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001353DOI Listing
July 2020
1.949 Impact Factor

Transvaginal ultrasound in evaluation and follow-up of ovarian granulosa cell tumors.

Int J Gynecol Cancer 2020 May 30. Epub 2020 May 30.

Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Milano, Italy.

Objective: Ultrasound features of granulosa cell tumors of the ovary are still poorly defined. The aim of this study is to widen current knowledge on the role of sonographic gray scale and pattern recognition in the characterization of these tumors and to compare the ultrasound characteristics of primary diagnosis and recurrences.

Methods: Transvaginal ultrasound images of primary diagnosis or recurrences of histologically-confirmed granulosa cell tumors of the ovary were retrospectively retrieved from a dedicated database designed for the collection of clinical and ultrasound data from January 2001 to January 2019. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001276DOI Listing

Clonal lineage from normal endometrium to ovarian clear cell carcinoma through ovarian endometriosis.

Cancer Sci 2020 May 30. Epub 2020 May 30.

Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Clear cell carcinoma of the ovary is thought to arise from endometriosis. In addition, retrograde menstruation of shed endometrium is considered the origin of endometriosis. However, little evidence supports cellular continuity from uterine endometrium to clear cell carcinoma through endometriosis at the genomic level. Read More

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http://dx.doi.org/10.1111/cas.14507DOI Listing

TCGA Classification of Endometrial Cancer: the Place of Carcinosarcoma.

Pathol Oncol Res 2020 May 29. Epub 2020 May 29.

Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Via Sergio Pansini, 5, 80131, Naples, Italy.

In 2013, The Cancer Genome Atlas (TCGA) Research Network found four novel prognostic subgroups of endometrial carcinoma: POLE/ultramutated (POLE), microsatellite-instable/hypermutated (MSI), copy-number-low/TP53-wild-type (CNL), and copy-number-highTP53-mutant (CNH). However, poor is known regarding uncommon histotypes of endometrial cancer. We aimed to assess the genetic profile of uterine carcinosarcoma (UCS) on the light of these findings. Read More

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http://dx.doi.org/10.1007/s12253-020-00829-9DOI Listing

Pan‑cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS‑CoV‑2 infection leading to COVID-19.

Int J Oncol 2020 Aug 26;57(2):533-539. Epub 2020 May 26.

Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.

Severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV2) is the cause of a new disease (COVID‑19) which has evolved into a pandemic during the first half of 2020. Older age, male sex and certain underlying diseases, including cancer, appear to significantly increase the risk for severe COVID‑19. SARS‑CoV‑2 infection of host cells is facilitated by the angiotensin‑converting enzyme 2 (ACE‑2), and by transmembrane protease serine 2 (TMPRSS2) and other host cell proteases such as cathepsin L (CTSL). Read More

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http://dx.doi.org/10.3892/ijo.2020.5071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307597PMC

[Analysis of prognosis and pregnancy outcomes of fertility-preserving treatment for patients with stage Ⅰa, grade 2 endometrial cancer].

Zhonghua Fu Chan Ke Za Zhi 2020 May;55(5):327-332

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.

To investigate the efficacy and pregnancy outcome of fertility-preserving treatment for patients with stage Ⅰa, grade 2 endometrial cancer (EC). Clinical data was retrospectively collected for EC or atypical endometrial hyperplasia (AEH) patients treated in Peking University People's Hospital, Foshan First People's Hospital of Guangdong Province and First Affiliated Hospital of Sun Yat-sen University, from 2010 to 2019. Inclusion criteria for fertility-preserving treatment included: (1) Age ≤45 years. Read More

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http://dx.doi.org/10.3760/cma.j.cn112141-20200118-00047DOI Listing

What is the impact of radical hysterectomy on endometrial cancer with cervical involvement?

World J Surg Oncol 2020 May 21;18(1):101. Epub 2020 May 21.

Departamento de Ginecología, Instituto Nacional de Cancerología, San Fernando 22, Tlalpan, 14080, Mexico City, Mexico.

Background: When endometrial carcinoma invades the cervical stroma, overall survival and disease-free survival decrease. However, it is still controversial whether patients in suspected stage II should be treated with radical hysterectomy. The goal of this study is to describe the role of radical hysterectomy in patients with endometrial carcinoma and cervical involvement. Read More

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http://dx.doi.org/10.1186/s12957-020-01876-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243320PMC

[A case of paraneoplastic sensory neuronopathy with anti-Hu antibody associated with large cell neuroendocrine carcinoma of the endometrium].

Rinsho Shinkeigaku 2020 Jun 19;60(6):441-445. Epub 2020 May 19.

Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital.

An 81-year-old woman was admitted to our hospital due to paresthesia of the extremities and difficulty in walking for three months. She underwent a total hysterectomy and bilateral salpingo-oophorectomy for large cell neuroendocrine carcinoma (LCNEC) of the endometrium seven months before the admission. The serum levels of neuron specific enolase (NSE) reduced after the surgery. Read More

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http://dx.doi.org/10.5692/clinicalneurol.60.cn-001393DOI Listing

Long-term survival in a stage IV small cell carcinoma of the endometrium.

Gynecol Oncol Rep 2020 May 6;32:100580. Epub 2020 May 6.

Department of Obstetrics, Gynecology, and Reproductive Science, University of Manitoba, Canada.

•Small cell carcinoma of the endometrium is a rare malignancy with poor survival.•A patient was diagnosed with stage IV small cell carcinoma of the endometrium.•She was treated with surgery, chemotherapy (cisplatin/etoposide) and radiotherapy. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218260PMC

Fallopian tube abnormalities in uterine serous carcinoma.

Gynecol Oncol 2020 May 11. Epub 2020 May 11.

Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Obstetrics and Gynecology, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands.

Objective: Uterine serous carcinoma (USC) is presumed to arise from endometrial intra-epithelial carcinoma (EIC), whereas tubo-ovarian high-grade serous carcinomas have similar precursor lesions in the Fallopian tube, i.e. serous tubal intra-epithelial carcinoma (STIC). Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.04.707DOI Listing

Endometrial Carcinoma and its Precursors.

Adv Exp Med Biol 2020 ;1242:59-72

Nezhat Surgery for Gynecology/Oncology, New York, NY, USA.

This chapter focuses on premalignant and malignant diseases of the endometrium (lining of the uterus). Endometrial carcinoma is the most common gynecologic cancer in the United States. Women have a 1 in 40 lifetime risk of being diagnosed with endometrial cancer, the fourth most common malignancy among women. Read More

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http://dx.doi.org/10.1007/978-3-030-38474-6_4DOI Listing

Diffuse Leiomyomatosis: Complete Myomectomy for Innumerable Small Nodules to Achieve Fertility Sparing and Childbearing.

Authors:
Ikuo Konishi

Surg J (N Y) 2020 May 29;6(Suppl 1):S50-S57. Epub 2019 Aug 29.

National Hospital Organization, Kyoto Medical Center, Kyoto, Japan.

Diffuse leiomyomatosis is a rare condition among benign smooth muscle neoplasms of the uterus, being defined as innumerable small myomatous nodules that mainly occur in the submucosal area. Young women with this disease suffer from menorrhagia, pains, and infertility. It is essential to perform extensive myomectomy after opening the endometrial cavity by a deep, median, longitudinal incision of the uterine corpus, followed by careful suture and reconstruction of the uterus for fertility spearing and childbearing in young women with this disease. Read More

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http://dx.doi.org/10.1055/s-0039-1693709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214083PMC

A 14-Methylation-Driven Differentially Expressed RNA as a Signature for Overall Survival Prediction in Patients with Uterine Corpus Endometrial Carcinoma.

DNA Cell Biol 2020 Jun 12;39(6):975-991. Epub 2020 May 12.

Center of Reproductive Medicine, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

DNA methylation has been implicated as an important mechanism for the development of uterine corpus endometrial carcinoma (UCEC), indicating that methylation-driven genes may be potential biomarkers for survival prediction. In this study, we aimed to identify a new prognostic methylation signature for UCEC based on differentially expressed genes (DEGs) and long noncoding RNAs (lncRNAs) (DELs). Sample-matched RNA-sequencing and methylation-array data were downloaded from The Cancer Genome Atlas database, by analysis of which a total of 269 DEGs and 4 DELs were identified to be methylation driven. Read More

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http://dx.doi.org/10.1089/dna.2019.5313DOI Listing
June 2020
2.055 Impact Factor

Prospective Evaluation of the Accuracy of A Training Program in Image Recognition by Narrow-Band Imaging Guided Hysteroscopy of Endometrial Neoplasms.

Gynecol Obstet Invest 2020 12;85(3):284-289. Epub 2020 May 12.

Department of Gynecology Minimally Invasive Center and Training Bases of Ministry of Health, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China,

Introduction: Narrow-band imaging (NBI) hysteroscopy by experienced hysteroscopists (EH) is useful for diagnosing endometrial neoplasms.

Objective: We investigated whether the diagnostic reliability of NBI could be improved by specific professional training.

Methods: Three levels of trainees who were Surgeons at our hospital were selected. Read More

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http://dx.doi.org/10.1159/000507929DOI Listing

Prognostic significance of VEGF and components of the plasminogen activator system in endometrial cancer.

J Cancer Res Clin Oncol 2020 Jul 11;146(7):1725-1735. Epub 2020 May 11.

Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.

Objective: The plasminogen activator system (PAS) and vascular endothelial growth factor (VEGF) are important in the carcinogenesis and play a key role in cancer invasion and mediating metastasis of carcinomas. The aim of the study was to evaluate the correlation of serum levels of VEGF and components of the PAS with clinicopathological risk factors and outcome in patients with endometrial cancer (EC).

Methods: Preoperative blood was collected from 173 patients treated for EC between 1999 and 2009. Read More

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http://dx.doi.org/10.1007/s00432-020-03225-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256031PMC

Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea.

Korean J Intern Med 2020 May 3;35(3):641-651. Epub 2018 Sep 3.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.

Background/aims: We aimed to evaluate site-specific cancer risk in diabetic patients and to investigate causal and temporal relationships by analyzing organ-specific cancer risk according to the duration of diabetes.

Methods: Using a database provided by the Korean National Health Insurance Service, we conducted a retrospective, population-based cohort study of adults aged ≥ 30 years from January 2005 to December 2013. To verify the possibility of detection bias or reverse causation, we compared hazard ratios (HRs) for each cancer according to the following duration of diabetes: less than 6 months, 6 months to 3 years, and more than 3 years. Read More

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http://dx.doi.org/10.3904/kjim.2017.402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214364PMC

Patients' and gynecologists' views on sentinel lymph node mapping in low- and intermediate-risk endometrial cancer: a Dutch vignette study.

Int J Gynecol Cancer 2020 Jun 7;30(6):813-818. Epub 2020 May 7.

Obstetrics and Gynecology, Radboudumc, Nijmegen, The Netherlands.

Objective: Sentinel lymph node (SLN) mapping in endometrial cancer is gaining ground. However, patient views on this new technique are unknown. The aim of this study was to determine factors important to patients and gynecologists when considering SLN mapping in low- and intermediate-risk endometrial cancer. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001138DOI Listing

Improving response to progestin treatment of low-grade endometrial cancer.

Int J Gynecol Cancer 2020 May 6. Epub 2020 May 6.

Queensland Centre for Gynaecological Cancer Research, The University of Queensland, Brisbane, Queensland, Australia.

Objectives: This review examines how response rates to progestin treatment of low-grade endometrial cancer can be improved. In addition to providing a brief overview of the pathogenesis of low-grade endometrial cancer, we discuss limitations in the current classification of endometrial cancer and how stratification may be refined using molecular markers to reproducibly identify 'low-risk' cancers which may represent the best candidates for progestin therapy. We also discuss constraints in current approaches to progestin treatment of low-grade endometrial cancer and perform a systematic review of predictive biomarkers. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001309DOI Listing

Two ultrastaging protocols for the detection of lymph node metastases in early-stage cervical and endometrial cancers.

Int J Gynecol Cancer 2020 May 5. Epub 2020 May 5.

Obstetrics and Gynecology, Hospital San Gerardo, Monza, Lombardia, Italy

Objective: To date, there is no universal consensus on which is the optimal ultrastaging protocol for sentinel lymph node (SLN) evaluation in gynecologic malignancies. To estimate the impact of different ultrastaging methods of SLNs on the detection of patients with nodal metastases in early-stage cervical and endometrial cancers and to describe the incidence of low-volume metastases between two ultrastaging protocols.

Methods: We retrospectively compared two ultrastaging protocols (ultrastaging-A vs ultrastaging-B) in patients with clinical stage I endometrial cancer or FIGO stage IA-IB1 cervical cancer who underwent primary surgery including SLN biopsy from October 2010 to December 2017 in our institution. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001298DOI Listing
May 2020
1.949 Impact Factor