32,826 results match your criteria Endometrium Carcinoma


Sentinel lymph node mapping using indocyanine green in patients with uterine and cervical neoplasms: restrictions of the method.

Arch Gynecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiology, Institute of Mother and Child, Warsaw, Poland.

Purpose: To establish the surgical, demographic and histopathological factors associated with inaccurate sentinel lymph nodes (SLNs) identification using indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging in uterine and cervical neoplasms during both open and laparoscopic surgery.

Methods: We reviewed patients with atypical endometrial hyperplasia (AEH), clinical stage I and II cervical cancer or uterine malignancies who underwent primary surgery with SLN mapping between September 2015 and January 2018. An analysis of patients' demographics, tumor factors and surgical approach was conducted. Read More

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http://dx.doi.org/10.1007/s00404-019-05063-6DOI Listing
February 2019

[S3 guidelines on the diagnosis and treatment of carcinoma of the endometrium : Requirements for pathology].

Pathologe 2019 Feb;40(1):21-35

Pathologisches Institut, Medizinische Fakultät, Ludwig-Maximilians-Universität München, München, Deutschland.

The present article summarises the relevant aspects of the S3 guidelines on endometrioid carcinomas. The recommendations include the processing rules of fractional currettings as well as for hysterectomy specimens and lymph node resections (including sentinel lymph nodes). Besides practical aspects, the guidelines consider the needs of the clinicians for appropriate surgical and radiotherapeutic treatment of the patients. Read More

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http://dx.doi.org/10.1007/s00292-019-0574-7DOI Listing
February 2019

Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial.

Lancet Oncol 2019 Feb 7. Epub 2019 Feb 7.

Department of Oncology, Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor.

Methods: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30859-3DOI Listing
February 2019
1 Read

Six months response rate of combined oral medroxyprogesterone/levonorgestrel-intrauterine system for early-stage endometrial cancer in young women: a Korean Gynecologic-Oncology Group Study.

J Gynecol Oncol 2019 Jan 7. Epub 2019 Jan 7.

Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.

Objective: To evaluate the efficacy of combined oral medroxyprogesterone acetate (MPA)/levonorgestrel-intrauterine system (LNG-IUS) treatment and to compare the diagnostic accuracy of endometrial aspiration biopsy with dilatation & curettage (D&C) in young women with early-stage endometrial cancer (EC) who wished to preserve their fertility.

Methods: A prospective phase II multicenter study was conducted from January 2012 to January 2017. Patients with grade 1 endometrioid adenocarcinoma confined to the endometrium were treated with combined oral MPA (500 mg/day)/LNG-IUS. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e47DOI Listing
January 2019
2 Reads
1.600 Impact Factor

Asian Society of Gynecologic Oncology International Workshop 2018.

J Gynecol Oncol 2019 Jan 14. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.

The Asian Society of Gynecologic Oncology International Workshop 2018 on gynecologic oncology was held in the Ajou University Hospital, Suwon, Korea on the 24th to 25th August 2018. The workshop was an opportunity for Asian doctors to discuss the latest findings of gynecologic cancer, including cervical, ovarian, and endometrial cancers, as well as the future of fertility-sparing treatments, minimally invasive/radical/debulking surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. Clinical guidelines and position statement of Asian countries were presented by experts. Read More

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https://ejgo.org/DOIx.php?id=10.3802/jgo.2019.30.e39
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http://dx.doi.org/10.3802/jgo.2019.30.e39DOI Listing
January 2019
2 Reads

Risk of malignancies among asymptomatic postmenopausal women with thickened endometrium: A cohort study.

Authors:
Zhe Li Lei Li

Medicine (Baltimore) 2019 Feb;98(6):e14464

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital.

The risk of malignancies and related factors among asymptomatic postmenopausal women with thickened endometrium in transvaginal sonography (TVS) are unclear.In this longitudinal study at a tertiary teaching hospital, all medical records of hysteroscopy were searched and retrospectively reviewed according to age, TVS results and diseases coded as International Classification of Diseases version 10. Asymptomatic postmenopausal women with endometrial thickness ≥5 mm from January 2006 to January 2016 were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000014464DOI Listing
February 2019
1 Read
5.723 Impact Factor

Could E-Cadherin and CD10 Expression be Used to Differentiate Between Atypical Endometrial Hyperplasia and Endometrial Carcinoma?

Int J Gynecol Pathol 2019 Mar;38(2):128-137

Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Endometrial carcinoma contributes to morbidity and mortality among female individuals worldwide. The role of E-cadherin expression, as an adhesion molecule, in endometrial carcinoma is controversial. Moreover, the role of CD10-expressing stromal cells in endometrial carcinoma is still unclear. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000492DOI Listing
March 2019
1 Read

A case of an endobronchial metastasis from an endometrial carcinoma.

SAGE Open Med Case Rep 2019 16;7:2050313X18823901. Epub 2019 Jan 16.

Department of Pathology, School of Medicine, Dongsan Medical Center, Keimyung University, Daegu, Korea.

A 73-year-old woman was referred to the pulmonology department for abnormal findings on chest computed tomography. She had undergone a laparoscopic staging operation including a hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvic node and para-aortic node dissection, and concurrent chemo-radiation therapy for endometrial serous carcinoma stage IIIc cancer 15 months earlier. A follow-up chest computed tomography after the chemotherapy showed that the right lower lobe bronchus was obstructed, and it was necessary to differentiate a primary lung malignancy from a metastasis and secretion. Read More

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http://dx.doi.org/10.1177/2050313X18823901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349978PMC
January 2019
1 Read

A Case of Spontaneous Regression of Recurrent Undifferentiated Carcinoma of the Endometrium.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Japanese Red Cross Ishinomaki Hospital, Japan.

We herein report a very rare case of spontaneous regression of recurrent undifferentiated carcinoma of the endometrium. An 80-year-old woman had undergone total hysterectomy with bilateral adnexectomy for undifferentiated carcinoma of the endometrium. The cancer recurred locally 10 months after surgery and then metastasized to the lung and liver. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.0376-17DOI Listing
February 2019
3 Reads

Chronic uterine inversion with malignancy mimicking carcinoma cervix.

BMJ Case Rep 2019 Feb 1;12(2). Epub 2019 Feb 1.

Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Chronic non-puerperal uterine inversion is a rare event, with only a handful of cases reported in literature. We report a case of a 64-year-old postmenopausal woman who presented with complaints of mass per vaginam and postmenopausal bleeding. On examination, she appeared to have third-degree cervical descent with an irregular growth seen over what appeared to be the cervix, biopsy of which showed keratinising squamous cell carcinoma. Read More

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http://dx.doi.org/10.1136/bcr-2018-225541DOI Listing
February 2019
1 Read

Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.

Surg Pathol Clin 2019 Mar 24;12(1):107-137. Epub 2018 Dec 24.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Mesenchymal tumors of the uterus comprise a heterogeneous group of neoplasms of varied biologic potential. In addition to being host to several anatomically unique entities, the uterus may contain mesenchymal neoplasms typically found elsewhere in the body. Although smooth muscle neoplasms are common, other mesenchymal neoplasms in this location are relatively rare. Read More

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http://dx.doi.org/10.1016/j.path.2018.10.005DOI Listing
March 2019
1 Read

[Precursor lesions of endometrial carcinoma].

Authors:
S F Lax

Pathologe 2019 Feb;40(1):13-20

Institut für Klinische Pathologie und Molekularpathologie, LKH Graz II, Standort West, Akademisches Lehrkrankenhaus der Medizinischen Universität Graz, Göstinger Straße 22, 8020, Graz, Österreich.

The 2014 WHO classification distinguishes between endometrial hyperplasia without atypia (EH) and atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia (AEH/EIN). AEH/EIN is characterized by crowded glands with cytologically atypical epithelium separated by little intervening stroma. Cellular atypia is characterized by nuclear enlargement and rounding, pleomorphism, loss of polarity, and presence of nucleoli. Read More

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http://dx.doi.org/10.1007/s00292-019-0568-5DOI Listing
February 2019

Cytological features of uterine carcinosarcoma: A retrospective study of 20 cases with an emphasis on the usefulness of endometrial cytology.

Diagn Cytopathol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan.

Background: Carcinosarcoma of the endometrium is a relatively rare but aggressive neoplasm. Endometrial cytological features of this type of tumor have been rarely reported. This study aimed to clarify the usefulness of endometrial cytological examination in the diagnosis of endometrial carcinosarcoma. Read More

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http://dx.doi.org/10.1002/dc.24152DOI Listing
February 2019

Relationship between Hypothyroidism and Endometrial Cancer.

Aging Dis 2019 Feb 1;10(1):190-196. Epub 2019 Feb 1.

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.

Thyroid dysfunction is involved in several types of carcinoma. Hypothyroidism is one of the most common medical morbidities among patients with endometrial cancer; however, the related mechanism is unclear. Among the risk factors related to endometrial cancer, hypothyroidism interacts with metabolic syndrome, polycystic ovarian syndrome and infertility or directly acts on the endometrium itself, which may influence the development and progression of endometrial cancer. Read More

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http://dx.doi.org/10.14336/AD.2018.0224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345335PMC
February 2019
1 Read

Comparison and analysis of the clinicopathological features of SCEO and ECOM.

J Ovarian Res 2019 Jan 30;12(1):10. Epub 2019 Jan 30.

Department of Gynecology, obstetrics and gynecology hospital, Fudan university, Shanghai, 200,090, China.

Objective: The aim of our study was to evaluate and compare the differences in the clinicopathological variables and overall survival (OS) of synchronous primary cancers of the endometrium and ovary (SCEO) and endometrial cancer with ovarian metastasis (ECOM). In addition, we aimed to determine the characteristics of and effective treatments for patients with SCEO to avoid misdiagnosis and overtreatment.

Materials And Methods: A review of medical records from January 2009 to January 2017 revealed 111 patients with coexisting ovarian and endometrial carcinoma diagnosed at the Obstetrics and Gynecology Hospital of Fudan University. Read More

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http://dx.doi.org/10.1186/s13048-019-0485-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352368PMC
January 2019
1 Read

Abundance of mitochondrial superoxide dismutase is a negative predictive biomarker for endometriosis-associated ovarian cancers.

World J Surg Oncol 2019 Jan 30;17(1):24. Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, Shiga University of Medical Science, SetaTsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

Background: Endometrioid ovarian carcinoma and clear cell ovarian carcinoma are both classified as endometriosis-associated ovarian cancers (EAOCs). Despite the high rates of recurrence and mortality of EAOC, only a few prognostic biomarkers have been reported. Mitochondrial superoxide dismutase (SOD2) plays an important role in maintaining mitochondrial function through oxidative stress tolerance and contributes to chemotherapeutic resistance. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-019-1
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http://dx.doi.org/10.1186/s12957-019-1565-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354361PMC
January 2019
2 Reads

Diagnostic accuracy of saline contrast sonohysterography to detect endometrial polyps in women with postmenopausal bleeding: a systematic review and meta-analysis.

Ultrasound Obstet Gynecol 2019 Jan 28. Epub 2019 Jan 28.

Department of Obstetrics and Gynecology; Maastricht UMC+, Maastricht, GROW- School for Oncology and Developmental Biology.

Introduction: Postmenopausal bleeding is a common complaint and is related to several benign and malignant conditions. Frequent findings in women with postmenopausal bleeding are endometrial polyps. The risk of a focal (pre)malignancy in a polyp in women with postmenopausal bleeding is up to 6%. Read More

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http://dx.doi.org/10.1002/uog.20229DOI Listing
January 2019
1 Read

Kidney Carcinoma Ovarian Metastasis: Review of the Literature.

Cureus 2018 Nov 21;10(11):e3620. Epub 2018 Nov 21.

Department of Pathology, National and Kapodistrian University of Athens, Athens, GRC.

Ovarian metastasis is common with secondary tumors representing up to 15% of ovarian neoplasms. The malignancies most commonly involving the ovaries are carcinomas of the stomach, colon, breast, endocervix, endometrium, and lymphoma. Secondary ovarian involvement by kidney carcinoma occurs very rarely and is usually associated with widespread dissemination. Read More

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http://dx.doi.org/10.7759/cureus.3620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344066PMC
November 2018
1 Read

Expression and potential role of SNF5 in endometrial carcinoma.

BMC Womens Health 2019 Jan 25;19(1):16. Epub 2019 Jan 25.

Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, 110122, Liaoning, China.

Background: SNF5 is a key protein in regulating cell proliferation and apoptosis in various cancers. However, the physiological roles of SNF5 in Endometrial carcinoma (EC), which is one of the most frequent malignancies of the female reproduction worldwide, remains unclear. This study aims to investigate the role of SNF5 and its correlation with clinicopathologic characteristics in EC. Read More

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https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12905-019-0718-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346509PMC
January 2019
2 Reads

Abnormal hysteroscopy findings among a cross section of infertile Nigerian women.

Niger J Clin Pract 2019 Jan;22(1):9-15

Department of Obstetrics and Gynaecology, University of Portharcout Teaching Hospital, Port Harcourt, Nigeria.

Background: Intrauterine lesions are important causes of infertility. This study aims to evaluate the abnormal findings at hysteroscopy among infertile women seen in 2 new Fertility/Gynaecological Endoscopy units in Nigeria.

Methods: A prospective study of 159 infertile women who had diagnostic hysteroscopy in Nnamdi Azikiwe University Teaching hospital Nnewi and Holy Rosary Specialist Hospital, Onitsha to evaluate the intrauterine lesions seen. Read More

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http://dx.doi.org/10.4103/njcp.njcp_404_17DOI Listing
January 2019
5 Reads

Prognostic significance of lymphovascular space invasion in low-risk endometrial cancer.

Int J Gynecol Cancer 2019 Jan 21. Epub 2019 Jan 21.

Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Turkey.

Objective: The purpose of this study was to assess the prognostic significance of lymphovascular space invasion in women with low-risk endometrial cancer.

Methods: A dual-institutional, retrospective department database review was performed to identify patients with 'low-risk endometrial cancer' (patients having <50% myometrial invasion with grade 1 or 2 endometrioid endometrial cancer according to their final pathology reports) at two gynecologic oncology centers in Ankara, Turkey. Demographic, clinicopathological and survival data were collected. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000069DOI Listing
January 2019

The Significance Role of microRNA-200c as a Prognostic Factor in Various Human Solid Malignant Neoplasms: A Meta-Analysis.

J Cancer 2019 1;10(1):277-286. Epub 2019 Jan 1.

Department of Urology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China.

The aim of this study was to conduct a meta-analysis of 49 relevant studies to evaluate the prognostic value of miRNA-200c in various human malignant neoplasms. All relevant studies were identified by searching PubMed, Embase and Web of Science until August 15, 2018. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) of miRNA-200c for overall survival (OS) and progression-free survival (PFS)/recurrence-free survival (RFS)/disease-free survival (DFS) were calculated to investigate such associations. Read More

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http://dx.doi.org/10.7150/jca.27536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329861PMC
January 2019
1 Read

Role of endometrial sampling in cases with asymptomatic cervical polyps.

J Gynecol Obstet Hum Reprod 2019 Jan 17. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Tepecik Training and Research Hospital Izmir, 35170, Turkey. Electronic address:

Cervical polyps are benign neoplasms of the cervix and frequently asymptomatic; however, they may cause intermenstrual, postcoital, and postmenopausal bleeding. The excision of cervical polyps and necessity of endometrial sampling is remain controversial. The objective of our study was to determine the association between cervical polyps and smear and endometrial pathologies. Read More

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http://dx.doi.org/10.1016/j.jogoh.2019.01.005DOI Listing
January 2019
1 Read

Activin-like kinase 5 (ALK5) inactivation in the mouse uterus results in metastatic endometrial carcinoma.

Proc Natl Acad Sci U S A 2019 Jan 17. Epub 2019 Jan 17.

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030;

The endometrial lining of the uterine cavity is a highly dynamic tissue that is under the continuous control of the ovarian steroid hormones, estrogen and progesterone. Endometrial adenocarcinoma arises from the uncontrolled growth of the endometrial glands, which is typically associated with unopposed estrogen action and frequently occurs in older postmenopausal women. The incidence of endometrial cancer among younger women has been rising due to increasing rates of obesity, a major risk factor for the disease. Read More

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http://dx.doi.org/10.1073/pnas.1806838116DOI Listing
January 2019
5 Reads

Survival after a nationwide introduction of robotic surgery in women with early-stage endometrial cancer: a population-based prospective cohort study.

Eur J Cancer 2019 Jan 14;109:1-11. Epub 2019 Jan 14.

Department of Gynaecology and Obstetrics, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense C, Denmark; Department of Clinical Health, Faculty of Health Sciences, Clinical Institute, University of Southern Denmark, J.B. Winsløws Vej 19, 5000 Odense C, Denmark. Electronic address:

Purpose: The purpose of the study was to evaluate the association between a nationwide introduction of robotic minimally invasive surgery (RMIS) and survival in women with early-stage endometrial cancer.

Materials And Methods: Prospective data on consecutive women with early-stage endometrial cancer who underwent surgery during January 2005 to June 2015 in Denmark were identified in the nationwide Danish Gynaecological Cancer Database. Data were linked with national registries regarding comorbidity, education, income and death. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183155
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http://dx.doi.org/10.1016/j.ejca.2018.12.004DOI Listing
January 2019
4 Reads

[Uterine serous carcinoma accompany with serous endometrial intraepithelial carcinoma and papillary proliferation of the endometrium: report of a case].

Zhonghua Bing Li Xue Za Zhi 2019 Jan;48(1):51-53

Department of Pathology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.01.013DOI Listing
January 2019
1 Read

Clinical and Ultrasound Characteristics of the Microcystic Elongated and Fragmented (MELF) Pattern in Endometrial Cancer According to the International Endometrial Tumor Analysis (IETA) criteria.

Int J Gynecol Cancer 2019 Jan;29(1):119-125

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Objectives: To describe sonographic features of the microcystic elongated and fragmented (MELF) pattern of myometrial invasion (MI) using the International Endometrial Tumor Analysis (IETA) criteria; to assess the effect of the MELF pattern on preoperative ultrasound evaluation of MI; and to determine the relationship of the MELF pattern to more advanced stage (≥ IB) and lymph node metastases (LNM) in women with endometrioid endometrial cancer (EEC).

Methods/materials: We included 850 women with EEC from the prospective IETA 4 study. Ultrasound experts performed all ultrasound examinations, accordingto the IETA protocol. Read More

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http://ijgc.bmj.com/lookup/doi/10.1136/ijgc-2018-000045
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http://dx.doi.org/10.1136/ijgc-2018-000045DOI Listing
January 2019
6 Reads

Uncommon metastases of invasive lobular breast cancer to the endometrium: a report of two cases and review of the literature.

Pan Afr Med J 2018 9;30:268. Epub 2018 Aug 9.

Department of Gynecology and Obstetrics, Farhat Hached's University Hospital, Sousse, Tunisia.

Although it is known that breast cancer can metastasize to many organ sites, metastasis to the uterus is uncommon and usually occurs during widespread metastatic disease. Lobular carcinoma is not the most common histological subtypes of breast carcinoma, but it is the most frequent histologic type that causes gastrointestinal, gynecological and peritoneal metastases. The main symptoms of the uterine metastasis depend on the anatomic involvement site. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.268.16208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317397PMC
January 2019
1 Read

Current Status of Magnetic Resonance Imaging in Patients with Malignant Uterine Neoplasms: A Review.

Korean J Radiol 2019 Jan 27;20(1):18-33. Epub 2018 Dec 27.

Department of Medical Imaging and Intervention, Imaging Core Laboratory, Institute for Radiological Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

In this study, we summarize the clinical role of magnetic resonance imaging (MRI) in the diagnosis of patients with malignant uterine neoplasms, including leiomyosarcoma, endometrial stromal sarcoma, adenosarcoma, uterine carcinosarcoma, and endometrial cancer, with emphasis on the challenges and disadvantages. MRI plays an essential role in patients with uterine malignancy, for the purpose of tumor detection, primary staging, and treatment planning. MRI has advanced in scope beyond the visualization of the many aspects of anatomical structures, including diffusion-weighted imaging, dynamic contrast enhancement-MRI, and magnetic resonance spectroscopy. Read More

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http://dx.doi.org/10.3348/kjr.2018.0090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315066PMC
January 2019
1 Read
1.807 Impact Factor

Synchronous primary cancers of the endometrium and ovary versus endometrial cancer with ovarian metastasis: a single institution retrospective observational study.

Ultrasound Obstet Gynecol 2019 Jan 8. Epub 2019 Jan 8.

Istituto di Ginecologia e Ostetricia, Università Cattolica del Sacro Cuore, Roma, Italia.

Objective: To compare the ultrasound characteristics of patients with synchronous primary cancers of the endometrium and ovary versus those of patients with endometrial cancer with ovarian metastases.

Methods: This is a single retrospective observational study. We identified patients with a histological diagnosis of endometrial cancer and an ovarian malignant mass, who had undergone preoperative ultrasound examination, in order to compare the ultrasound features of ovarian malignant masses between patients with synchronous primary cancers of the endometrium and ovary (synchronous group) and patients with endometrial cancer with ovarian metastases (metastatic group). Read More

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http://doi.wiley.com/10.1002/uog.20213
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http://dx.doi.org/10.1002/uog.20213DOI Listing
January 2019
7 Reads

Association of statins, aspirin, and venous thromboembolism in women with endometrial cancer.

Gynecol Oncol 2019 Jan 4. Epub 2019 Jan 4.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

Objective: The anti-thrombogenic effects of statins and aspirin have been reported in various malignancies but have not been well examined in endometrial cancer. This study examined the association between statin and/or aspirin use and venous thromboembolism (VTE) risk in endometrial cancer.

Methods: This is a multi-center retrospective study examining 2527 women with endometrial cancer between 2000 and 2015. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.12.020DOI Listing
January 2019
1 Read

Insulin-like growth factor-II mRNA-binding protein 3 immunocytochemical expression in direct endometrial brushings: Possible diagnostic help in endometrial cytology.

Cytopathology 2019 Jan 6. Epub 2019 Jan 6.

Cancer Education and Research Center, Osaka University Graduate School of Medicine, Osaka, Japan.

Introduction: This study evaluated the immunocytochemical (ICC) expression of IMP3 in direct endometrial brushings processed as liquid-based cytology (LBC) samples of endometrioid adenocarcinoma (EAC), serous carcinoma (ESC) and surface papillary syncytial change (SPSC) with endometrial glandular and stromal breakdown (EGBD) to exploit its possible differential diagnostic aid.

Methods: In total, 333 samples of LBC samples were obtained from selected outpatients in parallel with Pipelle endometrial sampling. They consisted of 97 EAC (83 grade 1: EAC-1, 14 EAC-3), 35 ESC and 201 benign endometrial samples (51 proliferative, 42 secretory, 38 atrophic, 70 SPSC with EGBD). Read More

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http://dx.doi.org/10.1111/cyt.12677DOI Listing
January 2019
2 Reads

Cancer susceptibility gene mutations in type I and II endometrial cancer.

Gynecol Oncol 2019 01 26;152(1):20-25. Epub 2018 Oct 26.

Mayo Clinic, Division of Gynecologic Oncology, United States of America.

Objectives: To determine the incidence of germline cancer predisposition gene mutations in patients with endometrial cancer (EC) subtypes.

Methods: Germline DNA was extracted from whole blood collected from consenting patients undergoing primary surgery for EC between 5/2005 and 11/2016. DNA samples were evaluated by product sequencing from a targeted multiplex PCR panel including 21 known/suspected cancer predisposition genes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183130
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http://dx.doi.org/10.1016/j.ygyno.2018.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326093PMC
January 2019
5 Reads

Diverse mutational signatures in endometrial cancer: implications for tumor etiology and evolution.

Gynecol Oncol 2019 01;152(1):1-2

Division of Gynecologic Oncology, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2018.12.004DOI Listing
January 2019
1 Read

[Role of Magnetic Resonance Imaging in distinguishing the origin of adenocarcinoma at the junction of the lower uterine segment and endocervix].

Zhonghua Zhong Liu Za Zhi 2018 Dec;40(12):912-916

Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 100021.

To evaluate Magnetic Resonance Imaging (MRI) at 3.0T in differential diagnosis of the origin of adenocarcinoma at the junction of the lower uterine segment and endocervix. 71 patients with adenocarcinoma at the junction of the lower uterine segment and endocervix were retrospectively collected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.12.008DOI Listing
December 2018
2 Reads

Diffusion kurtosis imaging of endometrial carcinoma: Correlation with histopathological findings.

Magn Reson Imaging 2019 Apr 30;57:337-346. Epub 2018 Dec 30.

Department of Human Pathology, Tokyo Medical and Dental University, Tokyo, Japan.

Purpose: In this study, we aimed to determine the usefulness of diffusion kurtosis imaging (DKI) as a noninvasive method for the evaluation of tumor invasion depth, histological grade, and lymph node metastasis in patients with endometrial carcinoma (EMC).

Materials And Methods: Our institutional review board approved this retrospective study and waived informed consent. In total, 24 patients suspected of having EMC were examined by a 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0730725X183056
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http://dx.doi.org/10.1016/j.mri.2018.12.009DOI Listing
April 2019
3 Reads

L1CAM as a Negative Prognostic Factor in Endometrioid Endometrial Adenocarcinoma FIGO Stage IA-IB.

Anticancer Res 2019 Jan;39(1):421-424

Department of Obstetrics and Gynecology, University Hospital Ostrava, Ostrava Poruba, Czech Republic.

Aims: In this study, we aimed to investigate how positivity for L1 cell adhesion molecule (L1CAM) was associated with outcome and relapse pattern in patients with Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage IA-IB endometrial cancer.

Materials And Methods: This retrospective study included 358 patients who underwent surgical treatment for endometrial carcinoma. Tumor samples from 312 patients (87. Read More

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http://dx.doi.org/10.21873/anticanres.13128DOI Listing
January 2019
2 Reads

Age should not be a limiting factor in laparoscopic surgery: a prospective multicenter cohort study on quality of life after laparoscopic hysterectomy.

Clin Interv Aging 2018 13;13:2517-2526. Epub 2018 Dec 13.

Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Purpose: A prospective, multicenter cohort study was performed on the implementation of laparoscopic hysterectomy (LH) in the Netherlands. The aim of this study was to evaluate the impact of LH on quality of life (QOL) with respect to age up to 6 months postoperatively.

Patients And Methods: Women with an indication for LH, either for benign conditions or early-stage low-risk endometrial cancer were included. Read More

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http://dx.doi.org/10.2147/CIA.S172965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296188PMC
February 2019
3 Reads

miR-142 Suppresses Endometrial Cancer Proliferation In Vitro and In Vivo by Targeting Cyclin D1.

DNA Cell Biol 2019 Feb 26;38(2):144-150. Epub 2018 Dec 26.

4 Department of Physical Examination, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Endometrial cancer (EC), a prevalent gynecologic tumor, is a great threat to women. We aimed to explore miR-142's effects on EC and the relevant mechanisms. Cell proliferation was evaluated with MTT, cell counting, and colony formation assay. Read More

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http://dx.doi.org/10.1089/dna.2018.4441DOI Listing
February 2019
2 Reads

[Expression and clinical significance of MMR protein and MLH1 promoter methylation testing in endometrial cancer].

Zhonghua Fu Chan Ke Za Zhi 2018 Dec;53(12):823-830

Department of Pathology, General Hospital of PLA, Beijing 100853, China.

To explore the expression and clinical significance of mismatch repair (MMR) protein and MLH1 promoter methylation testing in endometrial cancer (EC) . A total of 420 cases with EC diagnosed by the surgical pathology examination from the Department of Pathology of PLA General Hospital, MLH1, MSH2, MSH6 and PMS2 protein in EC were detected by immunohistochemistry and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) testing. (1) Of the 420 tumor cases, the total expression loss rate of MMR protein was 34. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.12.005DOI Listing
December 2018
2 Reads

[Clinicopathologic and survival analysis of synchronous primary endometrial and ovarian cancer].

Zhonghua Fu Chan Ke Za Zhi 2018 Dec;53(12):816-822

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To demonstrate the clinicopathological characteristics and determine the prognostic factors for women with synchronous primary endometrial and ovarian cancer (SEOC) . A retrospective analysis of 63 pathologically proven cases of SEOC diagnosed in Peking Union Medical College Hospital from January 2000 to May 2018 was carried out. (1) Clinical features: mean age at diagnosis was (48. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.12.004DOI Listing
December 2018
2 Reads

[Microcystic, elongated and fragmented invasion pattern in endometrial carcinoma: the clinicopathology analysis].

Zhonghua Fu Chan Ke Za Zhi 2018 Dec;53(12):811-815

Department of Pathology, Peking University People's Hospital, Beijing 100044, China.

To assess the clinical value for the clinicopathological features of microcystic elongated and fragmented (MELF) invasion in endometrial carcinoma (EEC) . The clinicopathological data of 108 cases of endometrial carcinoma with total hysterectomy, bilateral adnexectomy, and pelvic dissection were retrospectively analysis in Peking University People's Hospital from April 2015 to October 2016. Twenty-five patients with endometrial carcinoma showing MELF invasion pattern were collected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.12.003DOI Listing
December 2018
2 Reads

Estrogen affects the negative feedback loop of PTENP1-miR200c to inhibit PTEN expression in the development of endometrioid endometrial carcinoma.

Cell Death Dis 2018 Dec 18;10(1). Epub 2018 Dec 18.

Department of Pathology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.

Endometrial carcinoma is one of the most common malignancies in the female reproductive system. It is well-known that estrogen plays an important role in the pathogenesis of endometrioid endometrial carcinoma (EEC), and induces the cancer suppressor gene PTEN deletion. However, how estrogen affects PTEN expression remains unknown. Read More

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http://dx.doi.org/10.1038/s41419-018-1207-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315040PMC
December 2018
1 Read

Diagnostic efficacy of MRI for pre-operative assessment of ovarian malignancy in endometrial carcinoma: A decision tree analysis.

Magn Reson Imaging 2019 Apr 21;57:285-292. Epub 2018 Dec 21.

Department of Gynecology, The Central Hospital of Karamay, Xinjiang, Uyghur Autonomous Region, China. Electronic address:

Aim: Accurate preoperative assessment of ovarian malignancy in endometrial carcinoma helps in determining the decision to preserve the ovaries in individualized treatment. This study adopted decision tree method to evaluate the diagnostic efficiency of pelvic MRI and clinical data of patients for preoperative identification of endometrial carcinoma-combined ovarian malignancy (EC-OM).

Material And Methods: This retrospective study included a total of 801 patients, and postoperative pathological examinations identified 58 EC-OM group and 743 endometrial carcinoma cases without ovarian malignancy (EC group). Read More

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http://dx.doi.org/10.1016/j.mri.2018.12.008DOI Listing
April 2019
4 Reads

Investigational PI3K/AKT/mTOR inhibitors in development for endometrial cancer.

Expert Opin Investig Drugs 2019 Feb 21;28(2):131-142. Epub 2018 Dec 21.

a Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) , University of Genova , Italy.

Introduction: Endometrial cancer (EC) is the most common neoplasm of the female genital tract in developed countries. Despite the progress in early detection and treatment, a significant number of cases of advanced ECs are still diagnosed. These patients have few treatment options and a poor prognosis. Read More

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http://dx.doi.org/10.1080/13543784.2018.1558202DOI Listing
February 2019
1 Read
5.528 Impact Factor

Primary squamous cell carcinoma of endometrium: case report and literature review.

Pan Afr Med J 2018 16;30:208. Epub 2018 Jul 16.

Service de Radiothérapie, CHU Hassan II Fès, Maroc.

In this paper, we report a case of primary squamous cell carcinoma of the endometrium (PSCCE) with a literature review. A 64-year-old woman was admitted because of postmenopausal bleeding. The gynecological exam found bleeding from the endocervix. Read More

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http://www.panafrican-med-journal.com/content/article/30/208
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http://dx.doi.org/10.11604/pamj.2018.30.208.9654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294979PMC
January 2019
5 Reads

Clinical and prognostic value of F-FDG PET/CT in recurrent endometrial carcinoma.

Rev Esp Med Nucl Imagen Mol 2018 Dec 17. Epub 2018 Dec 17.

Medicina Nuclear, Universidad de Brescia y Hospital Civil de Brescia, Brescia, Italia.

Purpose: Endometrial carcinoma (EC) is a cancer with a good overall prognosis, except in cases of recurrent or advanced EC. The aim of this study was to assess the diagnostic performance, the prognostic value and the impact on therapeutic management of F-FDG PET/CT in suspected recurrent EC.

Materials And Methods: We retrospectively evaluated 157 patients with histologically proven EC and restaging F-FDG PET/CT for suspected recurrence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2253654X183017
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http://dx.doi.org/10.1016/j.remn.2018.09.005DOI Listing
December 2018
5 Reads

Oncological markers CA-125, CA 19-9 and endometriosis.

Medicine (Baltimore) 2018 Dec;97(51):e13759

Department of Psychiatry, First Faculty of Medicine, Charles University, Prague.

The endometrium tissue is functionally androgen related which plays an important role in women's fertility regulation. In addition recent findings show that endometrium related pathology is closely linked to disrupted androgen biosynthesis and associated regulatory functions. These findings also suggest that androgens might play an important role in endometrium related cancer pathology with significant implications for treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000013759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320090PMC
December 2018
1 Read

Upregulated delta-like protein 3 expression is a diagnostic and prognostic marker in endometrial cancer: A retrospective study.

Medicine (Baltimore) 2018 Dec;97(51):e13442

Upregulated delta-like protein 3 (DLL3) functions as a Notch ligand and has been a target for cancer therapy. The present study assessed DLL3 expression as a tumor marker for endometrial cancer.RNA-Seq expression data and clinicopathologic records from 545 patients with endometrial cancer were downloaded from The Cancer Genome Atlas database. Read More

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http://dx.doi.org/10.1097/MD.0000000000013442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320086PMC
December 2018
3 Reads

miR‑107‑5p promotes tumor proliferation and invasion by targeting estrogen receptor‑α in endometrial carcinoma.

Oncol Rep 2019 Mar 18;41(3):1575-1585. Epub 2018 Dec 18.

Department of Obstetrics and Gynecology, Shanghai General Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China.

The aberrant expression of miR107‑5p is closely related to the development of several types of human cancers. However, the role of miR‑107‑5p in endometrial carcinoma (EC) has not been fully confirmed. In the present study, we aimed to explore the function of miR‑107‑5p in EC carcinogenesis. Read More

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http://dx.doi.org/10.3892/or.2018.6936DOI Listing
March 2019
3 Reads
2.191 Impact Factor