33,116 results match your criteria Endometrium Carcinoma


HPV DNA integration site as proof of the origin of ovarian metastasis from endocervical adenocarcinoma: three case reports.

BMC Cancer 2019 Apr 23;19(1):375. Epub 2019 Apr 23.

Department of Pathology, Institut Curie, 75005, Paris, France.

Background: Most endocervical adenocarcinomas are human papillomavirus (HPV)-related cancers associated with p16 immunostaining. Ovarian metastasis from cervical cancer is a rare phenomenon, the mechanism of dissemination remains unclear. The diagnosis of metastasis may be difficult to establish when the ovarian neoplasm presents features consistent with primary tumor. Read More

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http://dx.doi.org/10.1186/s12885-019-5582-8DOI Listing

[Summary and expectation of the role of GnRHa in the treatment of breast cancer].

Authors:
X L Li Y Yu X Y Zong

Zhonghua Zhong Liu Za Zhi 2019 Apr;41(4):246-250

Department of Breast Surgery, Shanghai Jiao Tong University affiliated Shanghai Sixth People's Hospital, Shanghai 200233, China.

Gonadotropin-releasing-hormone analogues (GnRHa) are widely used in the treatment of premenopausal breast cancer. The anti-tumor effect of GnRHa is similar to that of surgical castration or chemotherapy, through reversibly inhibiting ovarian function and downregulating the estrogen level in premenopausal female. At the same time, GnRHa can protect the ovarian function, avoiding premature ovarian failure. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.04.002DOI Listing

Decreased ADAMTS-1, -9 and -20 levels in women with endometrial polyps: a possible link between extracellular matrix proteases and endometrial pathologies.

J Obstet Gynaecol 2019 Apr 22:1-6. Epub 2019 Apr 22.

b Department of Clinical Biochemistry , Ankara Numune Training and Research Hospital University of Health Sciences , Ankara , Turkey.

A disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs (ADAMTS) protein superfamily includes 19 secreted metalloproteases. Proteolytic substrates of ADAMTS enzymes have been linked to female reproductive function. Herein, we aimed to investigate serum ADAMTS-1, -9 and -20 levels in women with and without endometrial polyps (EPs). Read More

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http://dx.doi.org/10.1080/01443615.2019.1584890DOI Listing

Majority of -Mutant and -Deficient Colorectal Carcinomas Achieve Clinical Benefit From Immune Checkpoint Inhibitor Therapy and Are Microsatellite Instability-High.

JCO Precis Oncol 2019 4;3. Epub 2019 Mar 4.

Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: Microsatellite instability-high (MSI-H) colorectal carcinomas (CRCs) show high rates of response to immune checkpoint inhibitors (IOs). mutations and protein loss have been proposed as causes of resistance to IOs, yet they are enriched in MSI-H CRC. We aimed to characterize -mutant, IO-naive CRC. Read More

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http://dx.doi.org/10.1200/PO.18.00321DOI Listing

Synchronous Primary Malignancy of Female Genital Tract: A Report of Two Cases and Review of Literature.

J Midlife Health 2019 Jan-Mar;10(1):51-54

Department of Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Synchronous primary tumors of female genital tract is a rare phenomenon. We present two cases of anatomically related yet histologically unrelated tumors. The first patient is a 57 years postmenopausal female with synchronous low grade papillary urothelial carcinoma of the bladder and endometrioid adenocarcinoma of the endometrium. Read More

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http://dx.doi.org/10.4103/jmh.JMH_138_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459065PMC

Is there any difference between endometrial hyperplasia and endometrial carcinoma in terms of expression of TRPM2 and TRPM7 ion channels?

Turk J Med Sci 2019 Apr 18;49(2):653-660. Epub 2019 Apr 18.

Background/aim: This study compared TRPM2 and TRPM7 ion channel gene expression and immunohistochemical staining in endometrial hyperplasia and endometrium adenocarcinoma.

Materials And Methods: Sections were taken from paraffin blocks of 120 patients who were divided into 6 groups as follows: G1 (n = 20), proliferative endometrium (PE); G2 (n = 20), EH without atypia; G3 (n = 20), EH with atypia; G4 (n = 20), stage 1A, grade 1 EC; G5 (n = 20), stage 1A, grade 2 EC; and G6 (n = 20), stage 1A, grade 3 EC. TRPM2 and TRPM7 genes were analyzed with qRT-PCR in paraffin-embedded tissue samples. Read More

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http://dx.doi.org/10.3906/sag-1810-176DOI Listing
April 2019
1 Read

Reproductive outcomes following treatment for a gynecological cancer diagnosis: a systematic review.

J Cancer Surviv 2019 Apr 17. Epub 2019 Apr 17.

Kids Cancer Centre, Sydney Children's Hospital, Sydney, NSW, 2031, Australia.

Purpose: Fertility treatments are available for women diagnosed with a gynecological malignancy, which is important for women who desire a biological family subsequent to treatment. The objective of this study was to report reproductive outcomes following fertility-sparing treatment for a gynaecological cancer.

Methods: Electronic databases were searched to identify studies that reported on reproductive outcomes after treatment for a gynecological malignancy. Read More

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http://link.springer.com/10.1007/s11764-019-00749-x
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http://dx.doi.org/10.1007/s11764-019-00749-xDOI Listing
April 2019
2 Reads

Downregulation of lncrna uca1 as a diagnostic and prognostic biomarker for ovarian endometriosis.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):336-341. Epub 2019 Apr 11.

Department of Gynecology, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan City, Hubei Province, 430074, China.

Objective: Ovarian endometriosis seriously affects the quality of life of females, and long non-coding RNA lncRNA urothelial carcinoma-associated 1 (UCA1) plays pivotal roles in the pathogenesis of various ovarian diseases. However, the involvement of lncRNA UCA1 in ovarian endometriosis remains unknown to date. Therefore, the present study aims to study the role of UCA1 in ovarian endometriosis. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.65.3.336DOI Listing
March 2019
2 Reads

Conservative management of endometrial intraepithelial neoplasia in a patient with cirrhosis undergoing orthotopic liver transplant.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, IL.

Objective: The aim of the study was to review the management of endometrial hyperplasia in a woman undergoing liver transplantation for alcoholic cirrhosis.

Methods: This is a case presentation on a postmenopausal woman with a tissue diagnosis of endometrial intraepithelial neoplasia managed with a levonorgestrel intrauterine device, before and after liver transplantation. Full written informed consent was obtained from the patient to present her case. Read More

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http://dx.doi.org/10.1097/GME.0000000000001342DOI Listing
April 2019
1 Read

Effects of RNAi-induced Skp2 inhibition on cell cycle, apoptosis and proliferation of endometrial carcinoma cells.

Exp Ther Med 2019 May 13;17(5):3441-3450. Epub 2019 Mar 13.

Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.

The aim of the current study was to investigate the underlying mechanism of S-phase kinase associated protein 2 (Skp2) gene inhibition by lentivirus-mediated RNA interference (RNAi) on the cell cycle, apoptosis and proliferation of endometrial carcinoma HEC-1-A cells. A lentivirus shRNA vector targeting Skp2 was constructed and transfected into HEC-1-A cells. HEC-1-A cells transfected with a scramble sequence were used as negative controls. Read More

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http://dx.doi.org/10.3892/etm.2019.7392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447788PMC
May 2019
1 Read

Primary yolk sac tumor originating from the endometrium: A case report and literature review.

Medicine (Baltimore) 2019 Apr;98(15):e15144

The Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan.

Rationale: Yolk sac tumors (YSTs) are malignant germ cell tumors that secrete alpha-fetoprotein (AFP). These tumors commonly develop in infants, young children, and young women and often originate in the gonads. Primary endometrial YST is a very rare malignancy, and a primary endometrial YST in the absence of abnormal AFP levels is even rarer. Read More

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http://dx.doi.org/10.1097/MD.0000000000015144DOI Listing

A Rare Case of Primary Endometrial Hepatoid Adenocarcinoma on 18F-FDG PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Departments of Nuclear Medicine and.

Primary endometrial hepatoid adenocarcinoma is a rare tumor. We present a case of a 64-year-old woman with vaginal bleeding for 2 months and a markedly elevated serum α-fetoprotein of 3931 ng/mL. Hysteroscopic segmental curettage revealed endometrial adenocarcinoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002538DOI Listing
April 2019
3 Reads

Large cell neuroendocrine carcinoma of the endometrium: a report and review of the literature.

Gynecol Oncol Rep 2019 May 13;28:96-100. Epub 2019 Mar 13.

The University of Tennessee, Knoxville, Department of Obstetrics and Gynecology and Graduate School of Medicine, United States of America.

Large-cell neuroendocrine tumor of the endometrium is a rare tumor type which is difficult to diagnose. Our routine tissue sampling is often non-productive and these tumors can be mistaken for other poorly differentiated carcinomas. Sites of metastatic disease sometimes confuse the identification of the primary organ, and histological diagnosis requires a choice of neuroendocrine biomarkers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23525789193002
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http://dx.doi.org/10.1016/j.gore.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441730PMC
May 2019
2 Reads

[A suspected carcinoma finding in the uterus].

Pathologe 2019 Apr 9. Epub 2019 Apr 9.

Institut für Pathologie am Clemenshospital, Düesbergweg 128, 48153, Münster, Deutschland.

Epithelioid tumor cells of a uterine perivascular epithelioid cell tumor (PEComa) may mimic carcinoma cells in an endometrial sampling (pitfall). Immunohistochemistry (HMB45 positive, keratin negative) helps in the differential diagnosis. Read More

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http://dx.doi.org/10.1007/s00292-019-0587-2DOI Listing
April 2019
1 Read

Zone Formation of Lymphocyte Infiltration at the Invasive Front Results in the Prolonged Survival of Individuals With Endometrial Serous Carcinoma and Endometrioid Carcinoma With Serous Component.

Anticancer Res 2019 Apr;39(4):2085-2089

Department of Obstetrics and Gynecology, National Defense Medical College Hospital, Tokorozawa, Japan.

Background/aim: This study aimed to evaluate the clinical significance of lymphocyte infiltration (LI) for patients with endometrial serous carcinoma and those with endometrioid carcinoma including serous component.

Patients And Methods: Patients who underwent surgery at our hospital between 1990 and 2013 were identified. LI was classified into strong LI, defined as a continuous thick zone of LI, and weak LI, defined as the lack of zone or scattered small foci of LI at the invasive front. Read More

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http://dx.doi.org/10.21873/anticanres.13320DOI Listing
April 2019
2 Reads

Role of Positron Emission Tomography/Computed Tomography in Preoperative Assessment of Carcinoma Endometrium-a Retrospective Analysis.

Indian J Surg Oncol 2019 Mar 20;10(1):225-231. Epub 2018 Nov 20.

4Department of Onco - Pathology, HCG hospital, Bengaluru, India.

PET/CT has made significant inroads into routine oncological practice in recent times. In our study, we aim to determine its value in preoperative assessment of endometrial carcinoma. A retrospective study between January 2011 and March 2016 was conducted; we included all cases of carcinoma endometrium with a preoperative PET/CT scan. Read More

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http://link.springer.com/10.1007/s13193-018-0826-7
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http://dx.doi.org/10.1007/s13193-018-0826-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414595PMC
March 2019
6 Reads

Analysis of polymorphisms in genes associated with the FA/BRCA pathway in three patients with multiple primary malignant neoplasms.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1101-1112

a The National Engineering Research Center for Miniaturized Detection Systems, The College of Life Sciences , Northwest University , Xi'an , PR China.

Cases of more than three primary cancers are very rare. This study analyzed the genetic susceptibility of gene polymorphisms in three patients with multiple primary malignant neoplasms and examined the possible pathogenesis. The clinical data and whole genome sequence of three patients (1 with 5 primary cancers, 1 with 4 primary cancers, and 1 with 3 primary cancers) were aligned with a series of databases. Read More

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http://dx.doi.org/10.1080/21691401.2019.1575846DOI Listing
December 2019
1 Read

Letter to the Editor on 'dietary patterns and endometrial cancer: a meta-analysis'.

Eur J Cancer Prev 2019 05;28(3):243

Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

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http://dx.doi.org/10.1097/CEJ.0000000000000445DOI Listing
May 2019
2 Reads
3.031 Impact Factor

Treatment of uterine high-grade endometrial stromal sarcoma with apatinib combined with chemotherapy: A case report.

Medicine (Baltimore) 2019 Mar;98(13):e15050

Department of Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China.

Rationale: The standard treatment for uterine high-grade endometrial stromal sarcoma (HGESS) is chemotherapy after surgery. However, the traditional combination chemotherapy has certain limitation, for example, the cancer cells will quickly become resistant to the chemotherapy drugs. Apatinib is a small-molecule antiangiogenic agent which has shown promising therapeutic effect against diverse tumor, but it still remains unknown whether apatinib has an antitumor effect in patients with endometrial stromal sarcoma (ESS). Read More

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http://dx.doi.org/10.1097/MD.0000000000015050DOI Listing
March 2019
1 Read

Metastasis of Breast Lobular Carcinoma to Endometrium Presenting as Recurrent Abnormal Uterine Bleeding: A Case Report and Review of Literature.

Case Rep Pathol 2019 24;2019:5357194. Epub 2019 Feb 24.

Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.

There are few reports of breast cancer cases with uterine metastases. Here, we report a metastatic lobular carcinoma to endometrium presenting as abnormal uterine bleeding. Diagnosis was based in previous lobular breast carcinoma and immunohistochemistry. Read More

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http://dx.doi.org/10.1155/2019/5357194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409063PMC
February 2019
3 Reads

Decreased expression of cell polarity protein Scribble correlated with altered subcellular localization of the Crumbs homologue 3 protein in human adenomyotic endometrial cells.

J Obstet Gynaecol Res 2019 Mar 25. Epub 2019 Mar 25.

Department of Obstetrics and Gynecology of Shanghai Medical School, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People's Republic of China.

Aim: Previous studies have revealed that loss of cell apical-basal polarity contributed to the early stages of tumorigenesis. Adenomyosis involves a down-growth and aberrant implantation of the endometrial basalis into the myometrium. This study discovered aberrant expression of polarity protein Scribble (Scrib) and Crumbs homologue 3 protein (CRB3) in epithelial cells of diffuse adenomyosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jog.13952
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http://dx.doi.org/10.1111/jog.13952DOI Listing
March 2019
5 Reads

Dedifferentiated Carcinoma of the Endometrium Associated With Low-Grade Müllerian Adenosarcoma: A Clinicopathologic Case Report Including the Immunohistochemical and Molecular Profile.

Int J Gynecol Pathol 2019 Mar 22. Epub 2019 Mar 22.

Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester (S.B., L.M.H., X.M., H.B., E.F.C., A.K., K.C.) Department of Pathology, Services Hallmark Health System, Melrose (H.B.) Department of Pathology, Massachusetts General Hospital, Boston (K.C.), Massachusetts.

Dedifferentiated carcinoma is defined as undifferentiated carcinoma coexisting with a second component of FIGO grade 1 or 2 endometrioid carcinoma. It is a rare entity with highly aggressive behavior. Dedifferentiated carcinoma combined with another primary uterine tumor is even rarer. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000584DOI Listing
March 2019
1 Read

Diagnostic yield of magnetic resonance imaging and intraoperative frozen section in the determination of deep myometrial invasion in endometrial cancer.

Radiologia 2019 Mar 21. Epub 2019 Mar 21.

Servicio de Anatomía Patológica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Background And Objectives: The standard treatment for endometrial cancer is simple hysterectomy with bilateral salpingo-oophorectomy. Patients with high risk also benefit from lumbo-aortic lymphadenectomy. High risk patients include those with grades and histologic subtypes associated with poor prognosis and depth of myometrial invasion greater than 50% (M2). Read More

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http://dx.doi.org/10.1016/j.rx.2019.01.007DOI Listing
March 2019
1 Read

Survival outcomes of adjuvant radiotherapy and chemotherapy in women with stage I serous papillary and clear cell carcinoma of the endometrium: a Korean multicenter study.

J Gynecol Oncol 2019 May;30(3):e44

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Objective: To compare the survival outcomes of adjuvant radiotherapy and chemotherapy in women with uterine-confined endometrial cancer with uterine papillary serous carcinoma (UPSC) or clear cell carcinoma (CCC).

Methods: Medical records of 80 women who underwent surgical staging for endometrial cancer were retrospectively reviewed. Stage I UPSC and CCC were pathologically confirmed after surgery. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3802/jgo.2019.30
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http://dx.doi.org/10.3802/jgo.2019.30.e44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424839PMC
May 2019
8 Reads
1.600 Impact Factor

Dietary inflammatory index and risk of gynecological cancers: a systematic review and meta-analysis of observational studies.

J Gynecol Oncol 2019 May;30(3):e23

Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.

Objective: There has been growing body of literatures showing that chronic inflammation might play an important role in cancer development. This meta-analysis aimed to assess the association between the dietary inflammation index (DII) score and gynecological cancers.

Methods: A systematic search of PubMed, EMBASE and Web of Science up until October 20, 2018 was carried out to retrieve all related cohort and case-control studies. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424848PMC
May 2019
1 Read
1.600 Impact Factor

Oral tongue cancer in a patient with hereditary nonpolyposis colorectal cancer: A case report and review of the literature.

Oral Oncol 2019 May 15;92:92-93. Epub 2019 Mar 15.

Department of Otolaryngology, Loyola University Medical Center, Maywood, IL, United States.

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder characterized by mutations of mismatch repair genes leading to the early development of multiple malignancies. The most common malignancy is colorectal cancer but there is a strong association with malignancies of the ovary, endometrium, small intestine, stomach, skin, brain, and pancreas. We report a case of a 35-year-old female with a history of known HNPCC who presented with adenocarcinoma of the small intestine as well as a synchronous oral tongue squamous cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.008DOI Listing
May 2019
1 Read

Anti-Müllerian Hormone Expression in Endometrial Cancer Tissue.

Int J Mol Sci 2019 Mar 15;20(6). Epub 2019 Mar 15.

Department of Human Physiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.

Anti-Müllerian hormone (AMH) is a commonly known factor secreted by Sertoli cells, responsible for regression of the Müllerian ducts in male fetuses. AMH has also other functions in humans. In vivo and in vitro studies have shown that AMH inhibits cell cycle and induces apoptosis in cancers with AMH receptors. Read More

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http://dx.doi.org/10.3390/ijms20061325DOI Listing
March 2019
1 Read

Uterine and vaginal sarcomas resembling fibrosarcoma: a clinicopathological and molecular analysis of 13 cases showing common NTRK-rearrangements and the description of a COL1A1-PDGFB fusion novel to uterine neoplasms.

Mod Pathol 2019 Mar 16. Epub 2019 Mar 16.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.

Mesenchymal neoplasms of the uterus (corpus and cervix) encompass a heterogeneous group of tumors with differing morphologies, immunophenotypes and molecular alterations. With the advent of modern molecular techniques, such as next generation sequencing, newly defined genetic abnormalities are being reported in this group of neoplasms. Herein we report the clinicopathological and molecular features of a series of 13 spindle cell sarcomas of the uterus and vagina (10 cervix, 2 uterine corpus, 1 vagina) with morphology resembling fibrosarcoma. Read More

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http://www.nature.com/articles/s41379-018-0184-6
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http://dx.doi.org/10.1038/s41379-018-0184-6DOI Listing
March 2019
5 Reads
6.187 Impact Factor

Evolving trends in the management of high-intermediate risk endometrial cancer in the United States.

Gynecol Oncol 2019 03;152(3):522-527

Department of Radiation Oncology, University of Colorado Cancer Center, Aurora, CO, United States of America. Electronic address:

Objective: Gynecologic oncology group protocol 249 (GOG 249) is the contemporary US study that aimed to define the standard of care adjuvant therapy for patients with high-intermediate risk (HIR) endometrial cancer; patients were randomized to pelvic radiation therapy (RT) or vaginal brachytherapy (VBT) with chemotherapy (VBT-C). The preliminary results of GOG 249 were recently presented, yet the management of patients represented in this trial remains controversial. We set out to review US patterns of care for patients meeting eligibility criteria for GOG 249. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183147
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http://dx.doi.org/10.1016/j.ygyno.2018.12.010DOI Listing
March 2019
6 Reads

Women's preferences for cancer risk management strategies in Lynch syndrome.

Gynecol Oncol 2019 03;152(3):514-521

The University of Texas MD Anderson Cancer Center, Department of Behavioral Sciences, Houston, TX, United States of America.

Objective: We assessed preferences for cancer risk management strategies for Lynch syndrome (LS) in LS-affected women.

Methods: Women with LS aged ≥25 years evaluated 9 cancer risk management strategies using a visual analog scale (VAS) and modified standard gamble (SG). For the VAS, women ranked each strategy ranging from 0 (least preferred) to 100 (most preferred). Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.11.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422049PMC
March 2019
7 Reads

National trends, outcomes, and costs of radiation therapy in the management of low- and high-intermediate risk endometrial cancer.

Gynecol Oncol 2019 03;152(3):439-444

Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America. Electronic address:

Objective: To assess treatment patterns, outcomes, and costs for women with low-(LIR) and high-intermediate risk endometrial cancer (HIR) who are treated with and without adjuvant radiotherapy.

Methods: All patients with stage I endometrioid endometrial cancer who underwent surgery from 2000 to 2011 were identified from the SEER-Medicare database. LIR was defined as G1-2 tumors with <50% myometrial invasion or G3 with no invasion. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183136
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http://dx.doi.org/10.1016/j.ygyno.2018.11.005DOI Listing
March 2019
4 Reads

An innovative gynecological HDR brachytherapy applicator system for treatment delivery and real-time verification.

Phys Med 2019 Mar 7;59:151-157. Epub 2019 Mar 7.

Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.

The multichannel vaginal cylinder (MVC) applicator employed for gynecological high dose rate (HDR) brachytherapy increases dose delivery complexity, and thus makes the treatment more prone to errors. A quality assurance (QA) procedure tracking the source throughout dose delivery can detect dwell position and time errors in the multiple channels of the applicator. A new MVC system with integrated real time in vivo treatment delivery QA has been developed based on diodes embedded on the outer surface of the MVC. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.03.001DOI Listing
March 2019
1 Read

A Rare Case of Atypical Placental Site Nodule With an Emerging Intermediate Trophoblastic Tumor.

Int J Gynecol Pathol 2019 Mar 1. Epub 2019 Mar 1.

Department of Obstetrics/Gynecology (J.D.) Department of Obstetrics/Gynecology, Division of Gynecologic Oncology (D.M.O.), The Ohio State University College of Medicine Department of Pathology, The Ohio State University (W.C.), Columbus, Ohio Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland (B.M.R.).

Placental site nodule (PSN) is a benign lesion composed of chorionic-type intermediate trophoblastic cells and is typically an incidental finding in uterine or endocervical curettage specimens. Epithelioid trophoblastic tumor (ETT) and placental site trophoblastic tumor (PSTT) are intermediate trophoblastic neoplasms of chorionic and implantation site types, respectively. ETT is speculated to be the neoplastic counterpart of PSN. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000598DOI Listing
March 2019
6 Reads

NADPH oxidase 4 expression in the normal endometrium and in endometrial cancer.

Tumour Biol 2019 Feb;41(2):1010428319830002

1 Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Austria.

The aim of this study was to explore the role of NOX4 in the biology of the normal endometrium and endometrial cancer. NOX4 plays a key role in other adenocarcinomas and has been implicated in the pathogenesis of diabetes and obesity, which are important risk factors for endometrial cancer. NOX4 expression was assessed in 239 endometrial cancer and 25 normal endometrium samples by quantitative real-time polymerase chain reaction, in situ hybridization, and immunohistochemistry. Read More

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http://dx.doi.org/10.1177/1010428319830002DOI Listing
February 2019
3 Reads

New insights into early recovery after robotic surgery for endometrial cancer.

Gynecol Oncol 2019 Feb 23. Epub 2019 Feb 23.

Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark; Faculty of Health Sciences, Clinical Institute, University of Southern Denmark, Odense, Denmark.

Objective: To assess early recovery of physical health after robotic minimally invasive surgery (RMIS) for early-stage endometrial cancer using the European Organisation of Research and Treatment of Cancer Computer Adaptive Test Core questionnaire (EORTC CAT Core). The EORTC CAT Core provides individualised measurements while maintaining comparability. A hypothesis of individual complete recovery to baseline within three post-surgical weeks was evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193011
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http://dx.doi.org/10.1016/j.ygyno.2019.02.006DOI Listing
February 2019
7 Reads

Uterine Endometrial Stromal Tumors With Limited Infiltration: First Report of a Case Series Indicating Potential for Malignant Behavior.

Int J Gynecol Pathol 2019 Feb 21. Epub 2019 Feb 21.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (M.M., W.G.M.).

The distinction between a uterine endometrial stromal nodule (ESN) and low-grade endometrial stromal sarcoma (LGESS) is based on the nature of the interface between the lesion and the surrounding myometrium and the presence or absence of vascular invasion. Most LGESS exhibit widespread irregular myometrial invasion with or without vascular invasion, whereas ESNs are well-circumscribed without vascular invasion. Tavassoli and Norris proposed that minor marginal irregularity (up to 3 protrusions, each <3 mm beyond the main mass) is allowable in an ESN and these criteria have been incorporated into the World Health Organization Classification. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000593DOI Listing
February 2019
2 Reads

Major clinical research advances in gynecologic cancer in 2018.

J Gynecol Oncol 2019 Mar;30(2):e18

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Nineteen topics were selected as major clinical research advances in gynecologic oncology in 2018. For cervical cancer, the importance of human papillomavirus (HPV) testing alone as primary cervical cancer screening method and negative survival impact of minimally invasive surgery in early-stage cervical cancer were addressed. For ovarian cancer, cost-effectiveness of genetic testing to prevent cancer, use of analgesics and oral pill to reduce cancer risk, efficacy of secondary cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, update in the use of poly (ADP-ribose) polymerase inhibitor, and efficacy of anti-angiogenic targeted treatments, including bevacizumab and tyrosine kinase inhibitors, were reviewed. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393635PMC
March 2019
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Net Survival of Elderly Patients with Gynecological Cancer Aged Over 75 Years in 2006-2008

Asian Pac J Cancer Prev 2019 Feb 26;20(2):437-442. Epub 2019 Feb 26.

Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.

Background: The number of elderly patients with gynecological cancer in Japan is increasing in line with the aging of society. However, little has been reported on the survival of elderly patients aged 75 or older with gynecological cancer in Japan. Methods: To clarify survival in women aged 75 years or older with gynecological cancer, we analyzed data of 4,089 gynecological cancer cases (cervical cancer, 1,309 cases; endometrial cancer, 1,319 cases; and ovarian cancer, 1,461 cases) in patients aged 75 or older from 21 population-based cancer registries in Japan, diagnosed in 2006-2008. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.2.437DOI Listing
February 2019
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[Preliminary study of sequential multi-modality adjuvant chemotherapy and radiation for advanced endometrial cancer].

Zhonghua Fu Chan Ke Za Zhi 2019 Feb;54(2):103-109

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.

To evaluate the clinical outcomes and feasibility of multi-modality adjuvant chemotherapy and radiation, which was conducted as postoperative chemotherapy, radiation, and consolidation chemotherapy (CRC) mode for the treatment of advanced endometrial cancer. A retrospective analysis of 124 patients with International Federation of Gynecology and Obstetrics (FIGO) stages Ⅲ and Ⅳ endometrial cancer from Jan. 2004 to Oct. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.02.006DOI Listing
February 2019
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A four-miRNA signature as a novel biomarker for predicting survival in endometrial cancer.

Gene 2019 May 16;697:86-93. Epub 2019 Feb 16.

Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China; Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China. Electronic address:

Background: The microRNAs (miRNAs) have been validated as prognostic markers in many cancers. The aim of this study was to identify new miRNA prognostic biomarkers in endometrial cancer (EC) and to develop an expression-based miRNA signature to provide survival risk prediction for EC patients.

Methods: From TCGA database, the miRNA datasets of EC and clinical information were downloaded in April 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119193012
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http://dx.doi.org/10.1016/j.gene.2019.01.046DOI Listing
May 2019
7 Reads

Primary endometrial large cell neuroendocrine carcinoma with melanocytic differentiation.

Autops Case Rep 2018 Oct-Dec;8(4):e2018041. Epub 2018 Sep 26.

Federal University of Triângulo Mineiro (UFTM), Special Pathology Discipline. Uberaba, MG, Brazil.

High-grade endometrial carcinomas are aggressive neoplasms of difficult histological classification. Neuroendocrine differentiation in endometrial carcinomas is rare. This is the report of an endometrial large cell neuroendocrine carcinoma with foci of melanocytic differentiation in a 75-year-old woman with abnormal post-menopausal uterine bleeding for 2 years. Read More

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http://dx.doi.org/10.4322/acr.2018.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360826PMC
September 2018
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The risk of extra-ovarian malignancies among women with endometriosis: A systematic literature review and meta-analysis.

Crit Rev Oncol Hematol 2019 Feb 9;134:72-81. Epub 2019 Jan 9.

Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy. Electronic address:

We conducted a meta-analysis of studies reporting on the risk of extra-ovarian malignancies among women with endometriosis. Summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We explored causes of between-studies heterogeneity and assessed the presence of publication bias. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2018.12.009DOI Listing
February 2019
4 Reads

[Circulating tumor DNA assessment for gynaecological cancers management].

Bull Cancer 2019 Mar 11;106(3):237-252. Epub 2019 Feb 11.

Aix-Marseille university, CNRS U7258, Inserm U1068, institut Paoli-Calmettes, département d'oncologie médicale, CRCM, Marseille cedex 9, France; Aix-Marseille university, CNRS U7258, Inserm U1068, institut Paoli-Calmettes, CRCM, laboratoire d'oncologie prédictive, Marseille cedex 9, France. Electronic address:

Gynaecological cancers are frequent, with more than 16,000 cases per year in France for 6500 deaths. Few improvements in diagnostic methods, prognostic tools, and therapeutic strategies have occurred in the last two decades. Tumour genomic analyses from, at least in part, the Cancer Genome Atlas have identified some of the molecular alterations involved in gynaecological tumours growth and spreading. Read More

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http://dx.doi.org/10.1016/j.bulcan.2018.11.018DOI Listing
March 2019
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Comparative analysis of the value of diffusion kurtosis imaging and diffusion-weighted imaging in evaluating the histological features of endometrial cancer.

Cancer Imaging 2019 Feb 14;19(1). Epub 2019 Feb 14.

Department of MRI, The First Affiliated Hospital, Zhengzhou University, 1 Janshe East Road, Zhengzhou, 450000, People's Republic of China.

Purpose: This study evaluated and compared the performances of diffusion kurtosis imaging (DKI) and diffusion-weighted imaging (DWI) for diagnosing and histologically grading endometrial cancer.

Materials And Methods: In this retrospective study, DKI and DWI data for 61 patients with endometrial cancer and 30 patients with a normal endometrium were analyzed, and the mean kurtosis (MK), mean diffusion coefficient (MD) and apparent diffusion coefficient (ADC) values for the endometrial cancer tissue and normal endometrial tissue were acquired. The parameters for the normal endometrium group (G0) and the endometrial cancer groups (G1, G2 and G3) were compared and analyzed. Read More

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http://dx.doi.org/10.1186/s40644-019-0196-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376714PMC
February 2019
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Sentinel lymph node mapping using indocyanine green in patients with uterine and cervical neoplasms: restrictions of the method.

Arch Gynecol Obstet 2019 May 14;299(5):1373-1384. Epub 2019 Feb 14.

Department of Cardiology, Institute of Mother and Child, Warsaw, Poland.

Purpose: To establish the surgical, demographic and histopathological factors associated with inaccurate sentinel lymph nodes (SLNs) identification using indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging in uterine and cervical neoplasms during both open and laparoscopic surgery.

Methods: We reviewed patients with atypical endometrial hyperplasia (AEH), clinical stage I and II cervical cancer or uterine malignancies who underwent primary surgery with SLN mapping between September 2015 and January 2018. An analysis of patients' demographics, tumor factors and surgical approach was conducted. Read More

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http://dx.doi.org/10.1007/s00404-019-05063-6DOI Listing
May 2019
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[S3 guidelines on the diagnosis and treatment of carcinoma of the endometrium : Requirements for pathology].

Pathologe 2019 Feb;40(1):21-35

Pathologisches Institut, Medizinische Fakultät, Ludwig-Maximilians-Universität München, München, Deutschland.

The present article summarises the relevant aspects of the S3 guidelines on endometrioid carcinomas. The recommendations include the processing rules of fractional currettings as well as for hysterectomy specimens and lymph node resections (including sentinel lymph nodes). Besides practical aspects, the guidelines consider the needs of the clinicians for appropriate surgical and radiotherapeutic treatment of the patients. Read More

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http://dx.doi.org/10.1007/s00292-019-0574-7DOI Listing
February 2019
2 Reads

Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial.

Lancet Oncol 2019 Mar 8;20(3):383-393. Epub 2019 Feb 8.

Department of Oncology, Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor.

Methods: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30859-3DOI Listing
March 2019
4 Reads

Six months response rate of combined oral medroxyprogesterone/levonorgestrel-intrauterine system for early-stage endometrial cancer in young women: a Korean Gynecologic-Oncology Group Study.

J Gynecol Oncol 2019 Mar 7;30(2):e47. Epub 2019 Jan 7.

Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.

Objective: To evaluate the efficacy of combined oral medroxyprogesterone acetate (MPA)/levonorgestrel-intrauterine system (LNG-IUS) treatment and to compare the diagnostic accuracy of endometrial aspiration biopsy with dilatation & curettage (D&C) in young women with early-stage endometrial cancer (EC) who wished to preserve their fertility.

Methods: A prospective phase II multicenter study was conducted from January 2012 to January 2017. Patients with grade 1 endometrioid adenocarcinoma confined to the endometrium were treated with combined oral MPA (500 mg/day)/LNG-IUS. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393640PMC
March 2019
9 Reads
1.600 Impact Factor

Asian Society of Gynecologic Oncology International Workshop 2018.

J Gynecol Oncol 2019 Mar 14;30(2):e39. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.

The Asian Society of Gynecologic Oncology International Workshop 2018 on gynecologic oncology was held in the Ajou University Hospital, Suwon, Korea on the 24th to 25th August 2018. The workshop was an opportunity for Asian doctors to discuss the latest findings of gynecologic cancer, including cervical, ovarian, and endometrial cancers, as well as the future of fertility-sparing treatments, minimally invasive/radical/debulking surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. Clinical guidelines and position statement of Asian countries were presented by experts. Read More

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https://ejgo.org/DOIx.php?id=10.3802/jgo.2019.30.e39
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http://dx.doi.org/10.3802/jgo.2019.30.e39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393643PMC
March 2019
9 Reads
1.600 Impact Factor