38,927 results match your criteria Endometrium Carcinoma


Retreatment with progestin for recurrence after complete response with fertility-sparing treatment in patients with endometrial cancer.

Int J Gynecol Cancer 2022 Jun 24. Epub 2022 Jun 24.

Hosan Women's Hospital, Seoul, Republic of Korea.

Objective: To assess the outcomes of retreatment using progestin for recurrence after a complete response with fertility-sparing treatment in patients with early endometrial cancer.

Methods: We retrospectively reviewed the data of patients with presumed stage IA, grade 1 endometrioid endometrial cancer who developed intra-uterine recurrence after a complete response with fertility-sparing treatment using progestin. Oncological and pregnancy outcomes were analyzed after repeated fertility-sparing treatment. Read More

View Article and Full-Text PDF

MicroRNA 182, 183, 200a, and 200b exhibit strong correlations but no involvement in PTEN protein regulation in uterine endometrial carcinoma.

Pathol Res Pract 2022 Jun 17;236:153986. Epub 2022 Jun 17.

Laboratory of Histopathology and Cytopathology, Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Gunma 371-8514, Japan. Electronic address:

Objective: In this study, we focused on five microRNAs (miRNAs) that have been reported to regulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene expression, namely miR-182, miR-183, miR-200a, miR-200b, and miR-205, and examined their relationships with PTEN protein expression in endometrial cancer tissues.

Methods: By utilizing paraffin-embedded blocks of normal endometrium (NE) and endometrial carcinoma (EC) tissue (40 cases each), we measured the expression of miRNAs by real-time PCR. Conversely, we examined PTEN protein expression by immunohistochemistry and computer-assisted image analysis. Read More

View Article and Full-Text PDF

Disseminated Primary Uterine Hepatoid Adenocarcinoma with α-Fetoprotein Production Demonstrated on F-FDG PET/CT.

Diagnostics (Basel) 2022 Jun 12;12(6). Epub 2022 Jun 12.

Department of Oncology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.

We present the F-Fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) findings in a 57-year-old woman with post-menopausal bleeding diagnosed with hepatoid adenocarcinoma (HAC) with a primary tumour in the uterine corpus and a highly elevated level of serum-α-fetoprotein (S-AFP) at presentation. HAC is a variant of adenocarcinoma with hepatic differentiation representing a heterogeneous group of neoplasms that morphologically and immunphenotypically resemble hepatocellular carcinoma (HCC) but are of extrahepatic origin. Microscopically, they are usually poorly differentiated adenocarcinomas proliferating in solid sheets or in a trabecular or cord-like arrangement. Read More

View Article and Full-Text PDF

Two Biosensors for the Determination of Interleukin-6 in Blood Plasma by Array SPRi.

Biosensors (Basel) 2022 Jun 14;12(6). Epub 2022 Jun 14.

Bioanalysis Laboratory, Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland.

Interleukin-6 (IL-6) is a biomarker of inflammation, the advanced stage of COVID-19, and several cancers, including ovarian cancer. Two biosensors for the determination of IL-6 in blood plasma by array SPRi have been developed. One of these biosensors consists of the mouse monoclonal anti-IL-6 antibody as the receptor immobilized via the cysteamine linker. Read More

View Article and Full-Text PDF

CAN SKIN BE A MARKER FOR INTERNAL MALIGNANCY? EVIDENCE FROM CLINICAL CASES.

Acta Clin Croat 2021 Dec;60(4):711-721

1Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 3Unit of Dermatology and Venereology, Zabok General Hospital, Bračak/Zabok, Croatia; 4Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 5Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Although there are many single case reports on paraneoplastic dermatoses in the literature, there are very rare articles containing multiple cases. A retrospective study was performed to examine paraneoplastic dermatoses and accompanying malignancies based on skin manifestations and appropriate diagnostic evaluations. We recorded outcomes, current conditions, and surgical/oncologic treatments. Read More

View Article and Full-Text PDF
December 2021

COMPARISON OF TVUS, MRI, AND FROZEN SECTION METHODS IN PREOPERATIVE DETECTION OF MYOMETRIAL INVASION IN PATIENTS WITH ENDOMETRIAL CANCER.

Acta Clin Croat 2021 Dec;60(4):675-682

1Inonu University Medicine Faculty, Obstetrics and Gynecology Department, Malatya, Turkey; 2Inonu University Medicine Faculty, Pathology Department, Malatya, Turkey; 3Inonu University Medicine Faculty, Radiology Department, Malatya, Turkey.

We aimed to evaluate the depth of myometrial invasion preoperatively with transvaginal ultrasound, magnetic resonance imaging, and frozen section examination techniques in patients diagnosed with endometrial cancer. Our study included 65 patients. Transvaginal ultrasound and magnetic resonance imaging were performed in study patients in the preoperative period. Read More

View Article and Full-Text PDF
December 2021

Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.

Drug Des Devel Ther 2022 16;16:1847-1863. Epub 2022 Jun 16.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Background: Endometrial cancer (EC) is one of the most common gynecological malignancies, especially in postmenopausal women. Echinacoside (ECH) is a major natural bioactive ingredient derived from Cistanches Herba and Echinacea that has a variety of pharmacological effects. However, the efficacy and the mechanism of ECH against EC have not been elucidated yet. Read More

View Article and Full-Text PDF

A population-based study of outcomes in adjuvant radiotherapy for stage II endometrial carcinoma.

Int J Gynecol Cancer 2022 Jun 22. Epub 2022 Jun 22.

CancerCare Manitoba, Winnipeg, Manitoba, Canada.

Objective: Our study aimed to analyze recurrence and survival outcomes in stage II endometrial cancer patients treated with adjuvant radiotherapy at CancerCare Manitoba, a Canadian provincial cancer program.

Methods: This retrospective population-based cohort study identified all International Federation of Gynecology and Obstetrics (FIGO) 2009 stage II endometrioid type endometrial carcinoma diagnosed between January 1995 and December 2019. All patients underwent surgery followed by vaginal vault brachytherapy alone or external beam pelvic radiotherapy plus vaginal vault brachytherapy. Read More

View Article and Full-Text PDF

A novel algorithm to implement the molecular classification according to the new ESGO/ESTRO/ESP 2020 guidelines for endometrial cancer.

Int J Gynecol Cancer 2022 Jun 22. Epub 2022 Jun 22.

Department of Gynecology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.

Objective: To compare the risk class attribution with to those with according to the European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology (ESGO/ESTRO/ESP) 2020 guidelines on endometrial cancer, with a focus on risk group migration. Additionally, to evaluate the capability of a novel molecular analysis algorithm to reduce the number of required tests.

Methods: We conducted a retrospective study including all consecutive patients with endometrial cancer undergoing surgery and comprehensive molecular analyses between April 2019 and December 2021. Read More

View Article and Full-Text PDF

Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comprehensive Analyses of Clinicopathological, Molecular, and Prognostic Characteristics With Retrospective Review of 237 Endometrial Carcinoma Cases.

Cancer Genomics Proteomics 2022 Jul-Aug;19(4):526-539

Department of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea;

Background/aim: Uterine mesonephric-like adenocarcinoma (MLA) is a rare malignant tumor of the female genital tract.

Patients And Methods: We reviewed 237 endometrial carcinoma cases and investigated the clinicopathological and molecular characteristics of uterine MLA.

Results: We found that 3. Read More

View Article and Full-Text PDF

Anti-lipolysis-stimulated lipoprotein receptor monoclonal antibody as a novel therapeutic agent for endometrial cancer.

BMC Cancer 2022 Jun 21;22(1):679. Epub 2022 Jun 21.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: Endometrial cancer (EC) is a common gynecologic malignancy and patients with advanced and recurrent EC have a poor prognosis. Although chemotherapy is administered for those patients, the efficacy of current chemotherapy is limited. Therefore, it is necessary to develop novel therapeutic agents for EC. Read More

View Article and Full-Text PDF

Inhibition of BAD-Ser99 phosphorylation synergizes with PARP inhibition to ablate PTEN-deficient endometrial carcinoma.

Cell Death Dis 2022 Jun 20;13(6):558. Epub 2022 Jun 20.

Tsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, PR China.

Loss of phosphatase and tensin homolog (PTEN) impairs DNA double-strand repair and confers sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPis). However, PARPis also hyperactivate the MAPK and PI3K/AKT/mTOR pathways in PTEN-deficient endometrial carcinoma (EC), which allows the emergence of PARPi resistance. BCL-2-associated death promoter (BAD), integrates the common cell survival effects of the RAS/MEK/MAPK and PI3K/AKT/mTOR pathways. Read More

View Article and Full-Text PDF

Economic burden of cancer attributable to overweight in the Brazilian Unified Health System.

J Cancer Policy 2022 Jun 18;33:100345. Epub 2022 Jun 18.

Department of Preventive Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil. Electronic address:

Background: Alongside the rising prevalence of overweight and obesity in Brazil, there is expected to be increased direct healthcare costs of cancers. Herein, we estimated the economic costs of cancer attributable to overweight in the Brazilian Unified Health System (SUS), according to sex, type of cancer and geographic location (Federative Units).

Methods: The population attributable fraction (PAF) of fifteen types of cancer were estimated using body mass index (BMI) data of 85,715 adults (≥ 20 years) involved in the 2019 National Health Survey and relative risks of cancers from a meta-analysis. Read More

View Article and Full-Text PDF

Sentinel Lymph Node Biopsy in Endometrial Cancer - A Systematic Review and Quality Assessment of Meta-Analyses.

Rev Bras Ginecol Obstet 2022 Jun 20. Epub 2022 Jun 20.

Department of Obstetrics and Gynecology, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.

Objective:  To assess the quality of recent meta-analyses reviewing the diagnostic utility of sentinel node biopsy in endometrial cancer.

Methods:  With the MeSH terms and , PubMed and Embase databases were searched on October 21, 2020, and again on November 10, 2021, with meta-analysis and publication date filters set to since 2015. The articles included were classified with the A Measurement Tool to Assess Systematic Reviews (AMSTAR 2) assessment tool. Read More

View Article and Full-Text PDF

Clinical and Demographic Factors Associated With Follow-Up in a Hospital-Based Exercise Oncology Program.

Integr Cancer Ther 2022 Jan-Dec;21:15347354221105482

University of Utah, Department of Health and Kinesiology, Salt Lake City, UT, USA.

Objective: Despite the numerous benefits of regular exercise participation for cancer survivors, nearly 60% of survivors do not meet current guidelines. Hospital-based exercise oncology programs may be one strategy to promote exercise engagement as survivors have expressed a preference for exercise programs associated with a cancer hospital. However, follow-up rates in hospital-based exercise oncology programs can be low. Read More

View Article and Full-Text PDF

Abnormal accumulation of OFD1 in endometrial cancer with poor prognosis inhibits ciliogenesis.

Oncol Lett 2022 Jul 17;24(1):214. Epub 2022 May 17.

Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.

The aim of the present study was to examine primary cilia in endometrial tissue during the menstrual cycle and to clarify their morphological changes with different grades of endometrial cancer. Images of fluorescence immunostaining taken by confocal microscopy were used to count the number of primary cilia in normal endometrium and endometrioid carcinoma Grade 1 and Grade 3 specimens. To examine the association between autophagy and ciliogenesis in endometrioid carcinoma, the expression of p62/Sequestosome-1, a selective substrate for autophagy, and oral-facial-digital syndrome 1 protein (OFD1), a protein associated with ciliogenesis, were examined using images of fluorescence immunostaining taken by confocal microscopy. Read More

View Article and Full-Text PDF

Genistein induces long-term expression of progesterone receptor regardless of estrogen receptor status and improves the prognosis of endometrial cancer patients.

Sci Rep 2022 Jun 18;12(1):10303. Epub 2022 Jun 18.

Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Progesterone is used to treat uterine endometrial cancer in young patients wishing to preserve their fertility as well as in advanced or recurrent patients, but its response rate is limited. The antitumor effect of progesterone is mediated by progesterone receptor (PR) binding. Hence, loss of progesterone's therapeutic effect, i. Read More

View Article and Full-Text PDF

Update on Uterine Mesenchymal Neoplasms.

Surg Pathol Clin 2022 Jun 20;15(2):315-340. Epub 2022 May 20.

Department of Pathology, University of Chicago Medicine, 5837 South Maryland Avenue, MC 6101, Chicago, IL 60637, USA. Electronic address:

This review focuses on recent advances in epithelioid and myxoid uterine mesenchymal neoplasms, a category of tumors whereby diagnostic criteria have been rapidly evolving due to advances in molecular testing. Pertinent clinicopathological and molecular features are highlighted for perivascular epithelioid cell tumors, uterine tumors resembling ovarian sex cord tumors, BCOR/BCORL1-altered high-grade endometrial stromal sarcomas, and inflammatory myofibroblastic tumors. Novel developments in epithelioid and myxoid leiomyosarcomas are briefly discussed, and differential diagnoses with key diagnostic criteria are provided for morphologic mimickers. Read More

View Article and Full-Text PDF

Uncommon and Difficult High-Grade Endometrial Carcinomas.

Authors:
Jelena Mirkovic

Surg Pathol Clin 2022 Jun 20;15(2):301-314. Epub 2022 May 20.

Division of Laboratory Medicine and Molecular Diagnostics, Anatomic Pathology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room E401, Toronto, Ontario M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

This article presents features of uncommon high-grade endometrial carcinomas that often pose a significant diagnostic challenge. An update on undifferentiated and dedifferentiated endometrial carcinoma is first provided, followed by discussions on more recently defined entities such as mesonephric-like carcinoma of the endometrium and gastric-type endometrial carcinomas. Finally, endometrial carcinoma with germ cell or trophoblastic-like components is discussed. Read More

View Article and Full-Text PDF

Endometrial Cancer: An Update on Prognostic Pathologic Features and Clinically Relevant Biomarkers.

Surg Pathol Clin 2022 Jun;15(2):277-299

Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pok Fu Lam Road, Hong Kong SAR. Electronic address:

The prognosis of endometrial cancers has historically been determined by the evaluation of histologic typing, grading, and staging. Recently, molecular classification, pioneered by the 4 prognostic categories from The Cancer Genome Atlas Research Network, has been shown to independently predict the outcome, correlate with biomarker expression, and predict response to adjuvant chemotherapy. In modern-day pathology practice, it has become necessary to integrate the time-honored prognostic pathologic features with molecular classification to optimize patient management. Read More

View Article and Full-Text PDF

Novel Therapeutics in the Treatment of Uterine Sarcoma.

Am Soc Clin Oncol Educ Book 2022 Apr;42:900-909

Division of Hematology and Medical Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY.

Uterine sarcomas reflect the diversity of sarcoma as a whole. The most common histologies include leiomyosarcoma, high- and low-grade endometrial stromal sarcoma, and adenosarcoma. These are clinically and biologically heterogeneous diseases that are challenging to treat in the advanced setting. Read More

View Article and Full-Text PDF

Endometrial Cancer-Infiltrating Mesenchymal Stem Cells Exhibit Immunosuppressive Effects.

Cell Transplant 2022 Jan-Dec;31:9636897221104452

Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien.

Endometrial cancer is the most common gynecologic cancer with high heterogeneity. However, there are limited treatment options for advanced endometrial carcinoma. In recent years, immunotherapy has broadly been used for the treatment of various cancers. Read More

View Article and Full-Text PDF

A hierarchical spike-and-slab model for pan-cancer survival using pan-omic data.

BMC Bioinformatics 2022 Jun 17;23(1):235. Epub 2022 Jun 17.

Division of Biostatistics, University of Minnesota, Minneapolis, USA.

Background: Pan-omics, pan-cancer analysis has advanced our understanding of the molecular heterogeneity of cancer. However, such analyses have been limited in their ability to use information from multiple sources of data (e.g. Read More

View Article and Full-Text PDF

The time is now to start molecular subtyping high-intermediate and high-risk endometrial cancers.

Int J Gynecol Cancer 2022 Jun 15. Epub 2022 Jun 15.

University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA.

View Article and Full-Text PDF

The view in 2021 on screening and prevention of endometrial and ovarian cancer.

Authors:
Wiebren A Tjalma

Eur J Cancer Prev 2021 Dec 30;31(Suppl 1):S9-S10. Epub 2021 Dec 30.

Antwerp University Hospital - University of Antwerp, Antwerpen, Belgium.

View Article and Full-Text PDF
December 2021

FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity.

J Clin Invest 2022 Jun;132(12)

Department of Pathology.

FOXA2 encodes a transcription factor mutated in 10% of endometrial cancers (ECs), with a higher mutation rate in aggressive variants. FOXA2 has essential roles in embryonic and uterine development. However, FOXA2's role in EC is incompletely understood. Read More

View Article and Full-Text PDF

The effect of omentectomy on the blood levels of adipokines in obese patients with endometrial cancer.

Obes Res Clin Pract 2022 May-Jun;16(3):242-248. Epub 2022 Jun 11.

Department of Gynecologic Oncology, Muğla Sıtkı Koçman University, Education and Research Hospital, Muğla, Turkey. Electronic address:

Objective: To investigate the blood levels of adipokines in obese patients with endometrial cancer who have and have not undergone omentectomy.

Methods: Between September 2017 and September 2019, the study recruited 54 patients with endometrial cancer. Measurements were taken of blood levels of human leptin, perilipin-1, adiponectin, adipolin, resistin, visfatin, and estrone preoperatively and postoperatively before adjuvant therapy or at the end of one month. Read More

View Article and Full-Text PDF

Expression of apoptosis-related proteins in the pathogenesis of endometrial clear cell carcinoma.

Int J Clin Exp Pathol 2022 15;15(5):215-224. Epub 2022 May 15.

Department of Pathology, University of California San Diego San Diego, CA, USA.

Background: The balance of pro- and anti-apoptotic proteins plays a critical role in the regulation of cell death, and a disruption of this delicate balance may eventuate in carcinogenesis through a net reduction in apoptosis. Numerous chemotherapeutic strategies directly or indirectly target apoptotic pathways. However, a thorough assessment of apoptosis-related proteins has not previously been performed in endometrial clear cell carcinoma (CCC). Read More

View Article and Full-Text PDF

P504S/alpha-methylacyl-CoA racemase, HNF1β and napsin A in morular metaplasia and clear cell carcinoma of the endometrium: An immunohistochemical analysis.

Pathol Res Pract 2022 May 27;236:153953. Epub 2022 May 27.

Gynecopathology and Breast Pathology Unit, Department of Woman and Child's Health Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Gynecologic Oncology Unit, Department of Woman and Child's Health Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Aims: Endometrial morular metaplasia (MorM) can show cytoplasm clarification, which may mimic clear cell carcinoma (CCC), especially on biopsy. We aimed to assess the expression of CCC markers in MorM.

Methods: Twenty cases of MorM with areas of cytoplasmic clarification were assessed by immunohistochemistry for HNF1β, Napsin A, and P504S/alpha-Methylacyl-CoA racemase (AMACR); 60 tumors were selected as controls (20 classical MorM, 20 conventional squamous differentiation and 20 CCC). Read More

View Article and Full-Text PDF

circRNA circRIMS Downregulates miR-505 through Methylation to Suppress Cell Proliferation in Endometrial Cancer.

Crit Rev Eukaryot Gene Expr 2022 ;32(4):41-47

Zibo Central Hospital, Zibo City, Shandong Province, 255000, PR. China.

It is known that the circular RNA (circRNA) molecule circRIMS is overexpressed in gastric cancer and plays an oncogenic role. However, its role in other cancers is unknown. In this study, we analyzed its role in endometrial cancer (EC). Read More

View Article and Full-Text PDF