6,181 results match your criteria Endometritis

Immunological Testing in Assisted Reproductive Technology.

Semin Reprod Med 2021 Jun 23. Epub 2021 Jun 23.

Division of Biomedical Sciences, Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, Coventry, United Kingdom.

Fetal implantation requires carefully orchestrated involvement of the maternal immune system. Aberrant function within implantation has been suggested as a cause of implantation failure. The emergence of immunological theories of miscarriage has led to immunological testing as an adjuvant treatment in assisted reproductive technology; however, it remains controversial, with mixed evidence both for immunological cause and the benefits of immunological testing. Read More

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Wiad Lek 2021 ;74(6):1355-1359


Objective: The aim: To find out whether or not the presence of pregnancy loss and preterm birth was associated with the history of healthcare-associated infection (HAI) of women reproductive tract.

Patients And Methods: Materials and methods: We performed a retrospective cohort study was based on surveillance data. This study included 1,027 fertile women aged 21-50 years admitted to 8 hospitals from 2017-2019 with complaints to pregnancy loss or preterm birth. Read More

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Wiad Lek 2021 ;74(4):940-947


Objective: The aim: To carry out a statistical analysis of physical and reproductive health characteristics in women after ineffective reattempts of using assisted reproductive technologies and identify significant medical and social factors contributing to the development of chronic endometritis.

Patients And Methods: Materials and methods: We carried out a statistical analysis involving 177 outpatient medical records: group 1 includes 127 women aged under 45 with two or more ineffective attempts of in vitro fertilization; group 2 comprised 50 healthy women without reproductive disorders. The complete physical exam included past history, clinical and gynecologic examination, lab techniques and medical imaging according to outpatient medical records obtained during the follow-up care in Isida-IVF Medical Center LLC. Read More

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Wiad Lek 2021 ;74(4):934-939


Objective: The aim: To obtain the first national estimates of the current prevalence rate of SSI after CSEC and antimicrobial resistance of causing pathogens in Ukraine.

Patients And Methods: Materials and methods: We performed a retrospective multhicentre cogort study based surveillance data was conducted from May 2017 to December 2019. The study population consisted of all women who had a cesarean section in 11 regional women hospitals of Ukraine. Read More

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Induction within or after 12 hours of ≥ 36 weeks prelabor rupture of membranes: a systematic review and meta-analysis.

Am J Obstet Gynecol MFM 2021 Jun 18:100425. Epub 2021 Jun 18.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

Objective: To evaluate the incidence of chorioamnionitis in women with singleton gestations with ≥36 weeks prelabor rupture of membranes (PROM) induced with oxytocin within or after 12 hours or PROM.

Data Sources: The search was conducted using MEDLINE, Web of Sciences, Scopus, ClinicalTrial.gov, OVID and Cochrane Library as electronic databases from their inception until May 2020. Read More

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The effect of endocervical and catheter bacterial colonisation during fertilisation and embryo transfer (IVF-ET) on IFV success rate among asymptomatic women: a longitudinal prospective study.

J Obstet Gynaecol 2021 Jun 21:1-5. Epub 2021 Jun 21.

Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

The adverse effects of bacterial contamination during fertilisation and embryo transfer (IVF-ET) have been studied previously. However, data on asymptomatic women with positive bacterial culture and their IVF outcome are lacking. This prospective longitudinal study was conducted on 74 women undergoing IVF-ET, of whom specimens from the endocervix and ET catheter were taken and sent to a laboratory for microbiological assessment. Read More

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Postplacental Insertion of Levonorgestrel Intrauterine System Versus Copper Intrauterine Device: A Prospective Study.

J Obstet Gynaecol India 2021 Apr 20;71(2):150-155. Epub 2021 Jan 20.

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Shibin el Kom, Egypt.

Purpose: To compare between postplacental insertion of levonorgestrel intrauterine system versus copper intrauterine device regarding expulsion rates, patient satisfaction, complications, and continuation rates.

Methods: This prospective observational study was conducted on 1100 participants divided in to two groups: group (1) CU-IUD group and group (2) LNG-IUS group where women were assigned for postplacental insertion of either CU-IUD or LNG-IUS, respectively. Follow-up at 6 weeks, 3 and 6 months postpartum and data were collected and analyzed to evaluate outcomes. Read More

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Characterization of the vaginal and endometrial microbiome in patients with chronic endometritis.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 3;263:25-32. Epub 2021 Jun 3.

Instituto Bernabeu of Fertility and Gynaecology, Alicante, Spain.

Objective: To compare the endometrial and vaginal microbiome of women with and without chronic endometritis.

Study Design: A cohort study with 60 patients undergoing assisted reproductive treatment with their own or donated gametes was undertaken. Vaginal and endometrial samples were taken in the cycle prior to embryo transfer. Read More

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MiR-193a-3p targets LGR4 to promote the inflammatory response in endometritis.

Int Immunopharmacol 2021 Jun 15;98:107718. Epub 2021 Jun 15.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address:

Solving the reproductive barriers of dairy cows has become one of the most critical factors determining the dairy industry's development. Clinically, inflammation disease like endometritis is the most crucial cause in reducing dairy production's financial viability. MiR-193 family can induce cell apoptosis and differentiation has been reported in various diseases. Read More

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Using vaginal discharge score (VDS) grading system to evaluate the effect of clinical endometritis on reproductive performance of dairy cows in China.

Anim Reprod 2021 May 14;18(1):e20200228. Epub 2021 May 14.

College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.

Clinical endometritis (CE) is a major cause in affecting the reproductive performance of dairy cows. The objectives of this study were to ascertain the prevalence of CE and to evaluate the effect of CE on reproductive performance in dairy cows using vaginal discharge score (VDS) grading system. 803 dairy cows were examined by vaginoscope with 4-point VDS at 26 ± 3 days in milk (DIM) and classified into six groups: non-endometritis with VDS 0 (control; CON), endometritis with VDS 1 (MEM), non-treated endometritis with VDS 2 (NTME), treated endometritis with VDS 2 (TME), non-treated endometritis with VDS 3 (NTPE), and treated endometritis with VDS 3 (TPE). Read More

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Redefining chronic endometritis: the importance of endometrial stromal changes.

Fertil Steril 2021 Jun 10. Epub 2021 Jun 10.

Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

Objective: To develop diagnostic criteria for chronic endometritis and compare the prevalence of chronic endometritis between women with recurrent pregnancy loss (RPL) and controls.

Design: Cohort study.

Setting: Single academic fertility center. Read More

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Treatments for Endometritis in Mares Caused by Streptococcus equi Subspecies zooepidemicus: A Structured Literature Review.

J Equine Vet Sci 2021 Jul 24;102:103430. Epub 2021 Feb 24.

College of Animal Science and Technology, China Agriculture University, Beijing, China. Electronic address:

Bacterial infections are the main causes of endometritis in mares. It is well known that the most common bacterial pathogen is Streptococcus equi subspecies zooepidemicus (SEZ). This structured review was completed according to the PRISMA procedure to search endometritis treatment protocols published between 1990 and 2020 it was our intent to evaluate the actual effects of different treatment protocols for endometritis caused by SEZ. Read More

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Hysteroscopic detection of Chronic Endometritis: Evaluating proposed hysteroscopic features suggestive of Chronic Endometritis.

J Gynecol Obstet Hum Reprod 2021 Jun 7:102182. Epub 2021 Jun 7.

Professor in Obstetrics and Gynaecology, Department of Obstetrics and Gynaecology, University Hospital of Ioannina, Greece.

Purpose: To evaluate the proposed criteria in a large sample and in additional subgroups in order to test the validity of the hysteroscopic features widely-accepted as suggestive of CE METHOD(S): All patients (n: 2675) underwent outpatient hysteroscopy, with the vaginoscopic approach technique. Hysteroscopic features such as, stromal oedema, diffuse or focal hyperaemia, "strawberry aspect", micropolyposis and endometrial polyps, are often indicate the presence of chronic endometritis. All hysteroscopic features, alone and in combination were applied in 7 (seven) different subgroups of the sample: total sample, women in reproductive age, women with infertility issues/IVF screening, women with history of recurrent miscarriages, menopausal women, and women with hysteroscopic indication of Abnormal Uterine Bleeding (AUB) in women of reproductive age and postmenopausal bleeding (PMB). Read More

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Prostaglandin E2 promotes Staphylococcus aureus infection via EP4 receptor in bovine endometrium.

Microb Pathog 2021 Jun 6;158:105019. Epub 2021 Jun 6.

Laboratory of Veterinary Pathology, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China. Electronic address:

Prostaglandin E2 (PGE) enhances Staphylococcus aureus infection but its mechanism is not well understood. Here, we examined the effect of PGE on Staphylococcal Protein A (SPA) expression in bovine endometrium and determined the role of select PGE receptors (i.e. Read More

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The effect of pegbovigrastim on early-lactation disease, production, and reproduction in dairy cows.

J Dairy Sci 2021 Jun 4. Epub 2021 Jun 4.

Department of Population Medicine, University of Guelph, Guelph, Ontario, Canada, N1G 2W1. Electronic address:

The objective of this randomized, double-blind, controlled trial was to evaluate the effect of pegbovigrastim (pegylated recombinant bovine granulocyte colony-stimulating factor) on early-lactation disease, milk yield, and reproduction on commercial dairy farms. A total of 1,607 Holstein cows from 6 farms in Ontario and Québec, Canada, were randomly assigned to receive two 2.7-mL subcutaneous injections of either 15 mg of pegbovigrastim (n = 798; Imrestor, Elanco) or sterile physiological saline (placebo; n = 809). Read More

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Genotype by heat stress interactions for production and functional traits in dairy cows from an across-generation perspective.

J Dairy Sci 2021 Jun 4. Epub 2021 Jun 4.

Institute of Animal Breeding and Genetics, Justus-Liebig-University Gießen, 35390 Gießen, Germany. Electronic address:

The aim of this study was to analyze time-lagged heat stress (HS) effects during late gestation on genetic co(variance) components in dairy cattle across generations for production, female fertility, and health traits. The data set for production and female fertility traits considered 162,492 Holstein Friesian cows from calving years 2003 to 2012, kept in medium-sized family farms. The health data set included 69,986 cows from calving years 2008 to 2016, kept in participating large-scale co-operator herds. Read More

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Delivery method of the placenta in cesarean deliveries and the effect of uterine incision repair area on morbidity: A randomized controlled study

Turk J Obstet Gynecol 2021 06;18(2):92-102

Adana Acıbadem Hospital, Clinic of Obstetrics and Gynecology, Adana, Turkey

Objective: We evaluated the effects of spontaneous or manual delivery of the placenta and repair of uterine incision inside or outside the abdomen on intraoperative blood loss, postoperative infection morbidity, and postoperative hospitalization time.

Materials And Methods: We conducted a prospective randomized controlled study with 150 patients among 160 patients who were indicated to undergo emergency cesarean procedures in our tertiary hospital. We divided the patient population into four groups. Read More

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Modulation of Bovine Endometrial Cell Receptors and Signaling Pathways as a Nanotherapeutic Exploration against Dairy Cow Postpartum Endometritis.

Animals (Basel) 2021 May 23;11(6). Epub 2021 May 23.

Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Science, Lanzhou 730050, China.

In order to control and prevent bovine endometritis, there is a need to understand the molecular pathogenesis of the infectious disease. Bovine endometrium is usually invaded by a massive mobilization of microorganisms, especially bacteria, during postpartum dairy cows. Several reports have implicated the Gram-negative bacteria in the pathogenesis of bovine endometritis, with information dearth on the potentials of Gram-positive bacteria and their endotoxins. Read More

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Genital Tract GAS Infection ISIDOG Guidelines.

J Clin Med 2021 May 10;10(9). Epub 2021 May 10.

German Centre for Infections in Gynecology and Obstetrics, at Helios University Hospital Wuppertal, 42283 Wuppertal, Germany.

There has been an increasing worldwide incidence of invasive group A streptococcal (GAS) disease in pregnancy and in the puerperal period over the past 30 years. Postpartum Group A streptococci infection, and in particular streptococcal toxic shock syndrome (TSS) and necrotizing fasciitis, can be life threatening and difficult to treat. Despite antibiotics and supportive therapy, and in some cases advanced extensive surgery, mortality associated with invasive group A streptococcal postpartum endometritis, necrotizing fasciitis, and toxic shock syndrome remains high, up to 40% of postpartum septic deaths. Read More

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Specific Seminal Plasma Fractions Are Responsible for the Modulation of Sperm-PMN Binding in the Donkey.

Animals (Basel) 2021 May 13;11(5). Epub 2021 May 13.

Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, ES-17003 Girona, Spain.

While artificial insemination (AI) with frozen-thawed sperm results in low fertility rates in donkeys, the addition of seminal plasma, removed during cryopreservation, partially counteracts that reduction. Related to this, an apparent inflammatory reaction in jennies is induced following AI with frozen-thawed sperm, as a high amount of polymorphonuclear neutrophils (PMN) are observed within the donkey uterus six hours after AI. While PMN appear to select the sperm that ultimately reach the oviduct, two mechanisms, phagocytosis and NETosis, have been purported to be involved in that clearance. Read More

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Microbial Prevalence and Antimicrobial Sensitivity in Equine Endometritis in Field Conditions.

Animals (Basel) 2021 May 20;11(5). Epub 2021 May 20.

Department of Animal Medicine and Surgery, Veterinary Faculty, Universitat Autònoma de Barcelona, ES-08193 Bellaterra, Spain.

Endometritis is one of the main causes of infertility in mares. In the present study, 363 mares with a history of repetitive infertility, and positive endometrial cytology and/or vaginal discharge were included. An endometrial swab for microbiological purposes plus sensitivity test was obtained from each mare. Read More

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Three Manual Noncommercial Methods to Prepare Equine Platelet-Rich Plasma.

Animals (Basel) 2021 May 21;11(6). Epub 2021 May 21.

Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana Champaign, Urbana, IL 61802, USA.

In light of PRP's increasing popularity in veterinary practice, this study aimed to compare three manual methods to prepare and cool equine PRP. The blood of 18 clinically healthy mares was collected via venipuncture in a blood transfusion bag (method 1), blood tubes (method 2), and a syringe (method 3). In method 1, samples were double centrifuged; method 2 involved one centrifugation, and in method 3 the syringe was kept in an upright position to sediment for 4 h. Read More

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Clinical effectiveness of adding azithromycin to antimicrobial prophylaxis for cesarean delivery.

Am J Obstet Gynecol 2021 May 27. Epub 2021 May 27.

Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine, Oklahoma City, OK.

Background: A recent large clinical trial demonstrated an approximately 50% decrease in the rate of postoperative infection in women who were laboring and/or had rupture of membranes for >4 hours and who received azithromycin in addition to standard preoperative antibiotic prophylaxis at the time of cesarean delivery. Given these results, our institution made a policy change in May 2017 to add azithromycin to standard preoperative prophylaxis for all cesarean deliveries.

Objective: This study aimed to evaluate the clinical effectiveness of adding azithromycin to preoperative antibiotic prophylaxis for cesarean delivery. Read More

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Effect of pegbovigrastim on clinical mastitis and uterine disease during a full lactation in grazing dairy cows.

PLoS One 2021 27;16(5):e0252418. Epub 2021 May 27.

Department of Animal Sciences, Wageningen University, Wageningen, the Netherlands.

In this randomized controlled trial on four commercial grazing dairy farms, we investigated whether pegbovigrastim (PEG) treatment affects clinical mastitis (CM) and uterine disease (i.e. retained placenta (RP), metritis and endometritis) occurrence during a full lactation. Read More

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Incremental Value of Three-Phase Bone Scintigraphy and Single-Photon Emission Computed Tomography-Computed Tomography in a Case of Postpartum PUO in the Wake of The Antibiotic-Resistance Era.

Indian J Nucl Med 2021 Jan-Mar;36(1):62-65. Epub 2021 Mar 4.

Department of Nuclear Medicine and Molecular Imaging, Apollo Hospitals, Chennai, Tamil Nadu, India.

Postpartum methicillin-resistant (MRSA) infection occurs in patients with complicated vaginal delivery or cesarean section. The infection can manifest as mastitis, endometritis, and if untreated may lead to toxic shock syndrome. We report a case of postpartum MRSA osteomyelitis diagnosed by 99mtechnetium-methylene diphosphonate skeletal scintigraphy and single-photon emission computed tomography-computed tomography (CT) that was further confirmed by magnetic resonance imaging and CT-guided biopsy. Read More

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Evaluation of mare endometrial cytology using the novel cytotape technique.

Anim Reprod Sci 2021 Jul 18;230:106770. Epub 2021 May 18.

Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA, 30605, USA.

The cytobrush is considered the method of choice to obtain endometrial samples. Rigid brush fibers, however, may induce endometrial irritation and bleeding, or cell fragmentation, decreasing quality and diagnostic value of the samples. It was hypothesized that samples collected using a novel cytotape would provide sample smears of greater quality and less blood contamination than the cytobrush. Read More

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A simple and reliable refractometric method to determine the total solids concentration of the cervico-vaginal bovine mucus samples.

Heliyon 2021 May 10;7(5):e07010. Epub 2021 May 10.

Faculty of Veterinary Sciences of the National University of Rosario, S2170 Casilda, Argentina.

Cervico-vaginal mucus (CVM) is a viscoelastic substance continuously produced by secretory cells of the endocervix and the vagina of cows. Its physicochemical composition varies depending on the hormonal status of the estrous cycle. In veterinary medicine refractometry is a widely diffused technique to determine total solids (TS) content of biological samples, but there are not published data of CVM total solids from refractometric measures. Read More

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Hemodynamic changes in cytokines, chemokines, acute phase proteins and prostaglandins in mares with subclinical endometritis.

Theriogenology 2021 Sep 14;171:38-43. Epub 2021 May 14.

Department of Theriogenology, Faculty of Veterinary Medicine, Giza, Egypt. Electronic address:

Apparently healthy mares with conception failure or embryonic loss may have subclinical endometritis (SE). Our objective was to document evidence of systemic immune responses against SE in mares. In apparently healthy (control) mares as well as those with chronic endometritis (ChE) or subacute suppurative endometritis (SSE), both considered classes of SE, serum concentrations of cytokines (IL-1β, IL-6, IL-10 and TNF), chemokines (IL-8), acute phase protein (SAA), and plasma concentrations of prostaglandins (PGF and PGE) were measured using validated enzyme linked immunoassays (EIA). Read More

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September 2021

Evaluation of different point-of-care tests to characterize the vaginal discharge of sows after parturition and parameters' correlation with subsequent reproductive performance.

Porcine Health Manag 2021 May 20;7(1):38. Epub 2021 May 20.

Clinic for Swine, Department for Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, CH-3012, Bern, Switzerland.

The lochia is the physiological uterine discharge post-partum, whereas abnormal fluids are often indicators of puerperal disorders in sows, which negatively influence the further reproductive performance. The aim of the study was to characterize the vaginal discharge in sows employing simple and feasible tests and to correlate the evaluated parameters with the subsequent reproductive performance of these sows. The birth process of 48 clinically healthy free farrowing sows was monitored and several parameters characterizing the vaginal discharge such as total amount, colour, amount of cells (somatic cell count) and cell characteristics (cytology) were collected daily from first to fifth day after parturition. Read More

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Prophylactic postoperative antibiotics after emergent cesarean delivery and risk of postpartum infection or wound complication.

J Matern Fetal Neonatal Med 2021 May 19:1-6. Epub 2021 May 19.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Background: Emergent cesarean delivery (CD) carries a high risk for postpartum infection. In cases with a "splash" povidone-iodine (PI) skin preparation, prophylactic postoperative antibiotics (PP-Abx) are sometimes utilized, but the benefit is unclear.

Objective: To evaluate if the use of PP-Abx decreases postpartum infection after emergent CD with "splash" PI skin preparation. Read More

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