5,580 results match your criteria Endometritis


Incorporating Precesarean Vaginal Preparation Into Standard of Care for Obstetrics.

Obstet Gynecol 2019 Mar 11. Epub 2019 Mar 11.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, College of Physicians and Surgeons, and the Department of Microbiology and Immunology, Graduate School of Arts and Sciences, Columbia University, New York, New York.

Postoperative infections remain a serious concern after cesarean delivery, the most common major surgical procedure in the United States. Multiple strategies have been proposed to combat this problem, including the addition of azithromycin to the standard preoperative antibiotic prophylaxis. However, as obstetricians, we have failed to uniformly adopt precesarean vaginal preparation despite convincing evidence from randomized controlled trials that this technique reduces postoperative rates of endometritis by more than 50%. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003153DOI Listing
March 2019
1 Read

The Effect of Non-penicillin Antibiotic Regimens on Neonatal Outcomes in Preterm Premature Rupture of Membranes.

AJP Rep 2019 Jan 7;9(1):e67-e71. Epub 2019 Mar 7.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology at Duke University Hospital, Durham, North Carolina.

 A 7-day course of a penicillin (PCN) and macrolide is standard of care (SAR) in preterm premature rupture of membranes (PPROM). Data regarding alternative antibiotic regimens are limited. We sought to assess the impact of non-PCN regimens on neonatal outcomes. Read More

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http://dx.doi.org/10.1055/s-0039-1683378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406027PMC
January 2019

Evaluating chronic endometritis in women with recurrent implantation failure and recurrent pregnancy loss by hysteroscopy and immunohystochemistry.

J Minim Invasive Gynecol 2019 Mar 6. Epub 2019 Mar 6.

Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Research Center for Thalassemia and Hemoglobinopathy of Ahvaz, Iran. Electronic address:

Study Objective: The identification of less invasive methods with acceptable diagnostic value for evaluating the intrauterine abnormalities can improve patients and physician satisfaction. Although, hysteroscopy plus biopsy have favorable predictive and diagnostic values, limited studies have evaluated its value, and the exact value of this method is not completely understood. So, this study is aimed at evaluating the prevalence of chronic endometritis in patients with RIF and RPL by hysteroscopy and Immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.02.016DOI Listing
March 2019
1 Read

Review: Chronic endometritis and its effect on reproduction.

J Obstet Gynaecol Res 2019 Mar 6. Epub 2019 Mar 6.

Department of Obstetrics and Gynecology, Shiga University of Medical Science, Otsu, Japan.

Aim: Chronic endometritis (CE) is a disease of continuous and subtle inflammation characterized by the infiltration of plasma cells in the endometrial stromal area. Although the clinical significance of CE has been thought in clinical practice for a long time because it is either asymptomatic or presents with subtle symptoms, recent studies have shown the potential adverse effects of CE on fertility. In the present review, we focus on the concept, diagnosis, etiology, pathophysiology, diagnosis, impact on reproduction and treatment for it to understand CE. Read More

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http://doi.wiley.com/10.1111/jog.13937
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http://dx.doi.org/10.1111/jog.13937DOI Listing
March 2019
3 Reads

Matrine alleviates Staphylococcus aureus lipoteichoic acid-induced endometritis via suppression of TLR2-mediated NF-κB activation.

Int Immunopharmacol 2019 Feb 26;70:201-207. Epub 2019 Feb 26.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, People's Republic of China. Electronic address:

Endometritis is one of the main diseases that causes great economic losses in the dairy industry. Recent studies have shown that matrine extracted from the traditional Chinese herb Sophora flavescens is an alkaloid with a broad range of bioactivities. Here, we aimed to investigate the protective effects of matrine on Staphylococcus aureus lipoteichoic acid (LTA)-induced endometritis in mice and elucidate the possible molecular mechanisms in vitro. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.033DOI Listing
February 2019
2 Reads
2.472 Impact Factor

Developing a Core Outcome Set for Cesarean Delivery Maternal Infectious Morbidity Outcomes.

Am J Perinatol 2019 Feb 28. Epub 2019 Feb 28.

Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana.

Objective:  To develop a core outcome set of primary outcomes for studies involving cesarean deliveries with infectious morbidity outcomes.

Study Design:  Authors reported primary outcomes from 11 Cochrane systematic reviews (SRs), 12 other SRs, and 327 randomized controlled trials (RCTs). These outcomes were condensed into 20 primary outcome groups. Read More

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http://dx.doi.org/10.1055/s-0039-1681095DOI Listing
February 2019
2 Reads

Effects of hypertonic dextrose and paraffin solution as non-antibiotic treatments of clinical endometritis on reproductive performance of high producing dairy cows.

Reprod Domest Anim 2019 Feb 27. Epub 2019 Feb 27.

Department of Epidemiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

The objective of this study is to compare the reproductive performance of cows affected by clinical endometritis (CE) following treatment with an intrauterine infusion of 50% dextrose solutions (DEX) and liquid paraffin (LP) as alternative therapies with routine treatments including PGF injection and intrauterine infusion of oxytetracycline (OTC). Moreover, the reproductive indices of cows treated with endometritis were compared with those of healthy ones. At postpartum reproductive tract examination (28-35 DIM) in one Iranian dairy farm, cows with CE without any selection were assigned to four groups: (1) OTC, a common treatment in Iran, was administered (5gr) to 396 cows, (2) PGF α(PG) wasinjectedto496 cows, (3) dextrose solution (DEX): intrauterine infusion of50% dextrose solution (200 ml) was done in 427 cows, and (4) liquid paraffin (LP) was administered (100 ml) to 423 cows via intrauterine route. Read More

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http://dx.doi.org/10.1111/rda.13424DOI Listing
February 2019
2 Reads

Validation of whole-body radiographs for examining uterine disorders in sexually intact female rabbits.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Feb 26;47(1):14-24. Epub 2019 Feb 26.

Clinic for small mammals, reptiles and birds, University of Veterinary Medicine Hannover, Foundation.

Objective: The present study evaluated whole-body radiographs of female rabbits regarding uterine disorders.

Material And Methods: Based on radiographs of 143 rabbits, visibility, size, shape and density of the uterus, nutritional status of the animal and possible metastasis in other organs were examined. A suspected diagnosis was deduced. Read More

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http://dx.doi.org/10.1055/a-0804-1704DOI Listing
February 2019
2 Reads

Increase of pregnancy rate after multiple periovulatory inseminations in mares.

Tierarztl Prax Ausg G Grosstiere Nutztiere 2019 Feb 26;47(1):18-24. Epub 2019 Feb 26.

Swiss Institute of Equine Medicine, Vetsuisse Faculty University of Berne, and Agroscope.

Objective: There exist differences in the reproductive behavior of stallions and mares under free-running and domestic in-hand breeding conditions. Contrary to artificial insemination programs, a stallion mates a mare multiple times per estrus under natural conditions. The objective of this study was to determine if multiple periovulatory artificial inseminations (MI), four times in two different time intervals instead of two, would result in increased pregnancy outcome or higher incidences of breeding induced endometritis. Read More

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http://dx.doi.org/10.1055/a-0803-1211DOI Listing
February 2019
2 Reads

Non-canonical Inflammasome-Mediated IL-1β Production by Primary Endometrial Epithelial and Stromal Fibroblast Cells Is NLRP3 and Caspase-4 Dependent.

Front Immunol 2019 5;10:102. Epub 2019 Feb 5.

Comparative Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Inflammation of the post-partum uterus is a normal physiological event, crucial for tissue involution and repair. However, in the bovine, some cows fail to resolve this inflammation, resulting in endometritis, which compromises fertility. Earlier work has identified upregulated expression of the potent inflammatory cytokine IL-1β early post-partum, in cows which subsequently develop endometritis. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371858PMC
February 2019
2 Reads

Successful Implantation and Live Birth Following Autologous Platelet-rich Plasma Treatment for a Patient with Recurrent Implantation Failure and Chronic Endometritis.

In Vivo 2019 Mar-Apr;33(2):515-521

Reproductive Medicine Unit, Genesis Athens Clinic, Athens, Greece.

Background/aim: Patients diagnosed with chronic endometritis (CE) may fail to respond to standard antibiotic treatment. The driver behind the approach reported here was the imperative need for alternative therapeutic solutions.

Case Report: This case report presents a woman with CE and premature ovarian insufficiency having experienced repeated implantation failures following donated embryo transfers. Read More

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http://dx.doi.org/10.21873/invivo.11504DOI Listing
November 2018

Possibility for non-invasive diagnosis of chronic endometritis in women at risk during pregravid preparation.

Wiad Lek 2019 ;72(1):64-67

Ukrainian Medical Stomatological Academy, Poltava, Ukraine.

Objective: Introduction: Detection and treatment of chronic endometritis (CE) is clinically significant, though involves intrauterine intervention to collect endometrium. The aim: To estimate the possibility to use fertility α2-microglobulin (FAMG) as the marker of the high risk for CE.

Patients And Methods: Materials and methods: 70 women with CE who were planning pregnancy were tested for FAMG in menstrual blood. Read More

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January 2019
1 Read

Three-dimensional 3D ultrasound combined with power Doppler for the differential diagnosis of endometrial lesions among infertile women.

Int J Gynaecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

Reproductive Medicine Center, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.

Objective: To assess three-dimensional (3D) ultrasound combined with power Doppler (PD) for the differential diagnosis of endometrial lesions among infertile women.

Methods: A prospective study carried out at a reproductive medicine center in Luoyang, China, between January and December 2015. The inclusion criteria were asymptomatic infertility with normal endometrium or specific endometrial lesions. Read More

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http://dx.doi.org/10.1002/ijgo.12787DOI Listing
February 2019
4 Reads

Susceptibility of endometrial isolates recovered from women with clinical pelvic inflammatory disease or histological endometritis to antimicrobial agents.

Anaerobe 2019 Feb 10;56:61-65. Epub 2019 Feb 10.

Magee-Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA, 15213, USA; University of Pittsburgh, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Hospital, 300 Halket Street, Pittsburgh, PA, 15213, USA. Electronic address:

The CDC recommended outpatient treatment of pelvic inflammatory disease (PID) is an intramuscular dose of ceftriaxone plus 14 days of doxycycline, with or without metronidazole. European guidelines (2017) include moxifloxacin plus ceftriaxone as a first line regimen, particularly for women with Mycoplasma genitalium-associated PID. However, the susceptibility of bacteria recovered from the endometrium of women with PID to moxifloxacin is unknown. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.02.005DOI Listing
February 2019
9 Reads

Role of uterine blood flow disturbances in the development of late gestosis.

Wiad Lek 2018 ;71(9):1719-1721

Ukrainian Medical Stomatological Academy, Poltava, Ukraine.

Objective: Introduction: Chronic endometritis (CE) associated lesions lessen the implantation potential of endometrium and aggravate the course of invasive processes in the uterine vessels The aim: Study of changes in doplerometric parameters of blood flow in spiral and uterine arteries in 17-18 weeks of pregnancy in women with СE in anamnesis.

Patients And Methods: Materials and methods: Сalculation of systolic/diastolic ratio (SDR), pulse index (PI) and resistive index (RI) has been carried out in 70 pregnant had CE in past history and 10 healthy pregnant women who experienced neither chronic endometritis before pregnancy nor preeclampsia.

Results: Results: SDR in SA patients with CE in history and follow-up development of preeclampsia is by 19& higher the control values (р<0,05); PI was 85& higher than the similar one in the control group and RI was 86& higher (р<0,01). Read More

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January 2018
5 Reads

The impact of ecbolic therapy in the early postpartum period on uterine involution and reproductive health in dairy cows.

J Vet Med Sci 2019 Feb 5. Epub 2019 Feb 5.

Department of Population Medicine, Ontario Veterinary College, University of Guelph.

Postpartum uterine disease due to poor uterine involution continues to be a significant factor that contributes to poor reproductive efficiency in dairy cattle. Therapy that increases the frequency, duration and strength of uterine contractions in the postpartum period might enhance uterine involution, resulting in improved reproductive performance. The objective of this clinical trial was to study the effect of two uterine ecbolic therapies, oxytocin and prostaglandinF2α on uterine involution, postpartum endometritis, and reproductive performance. Read More

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http://dx.doi.org/10.1292/jvms.18-0617DOI Listing
February 2019
1 Read

Chronic Endometritis, a Common Disease Hidden Behind Endometrial Polyps in Premenopausal Women: First Evidence From a Case-Control Study.

J Minim Invasive Gynecol 2019 Jan 29. Epub 2019 Jan 29.

Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy (Dr. Resta).

Study Objective: To investigate the correlation between endometrial polyps (EPs) and chronic endometritis (CE).

Design: Single-center retrospective case-control study.

Setting: Academic center. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.01.012DOI Listing
January 2019
2 Reads
1.575 Impact Factor

[Diagnosis of acute endometritis on hematologic indicators, and given discriminant models.]

Klin Lab Diagn 2018 ;63(6):361-364

GBUZ "Maternity hospital Essentuki", 357635, Yessentuki, Russia.

Diagnosis of acute endometritis, despite advances in modern medicine due to the prevalence of erased forms remains difficult. The purpose of the study is to improve the diagnosis of acute endometritis by informative indicators of peripheral blood and discriminant models. In 154 patients with acute postpartum endometritis and 103 patients with uncomplicated post-Natal period studied, the indicators of General blood analysis with the assessment of informativeness, with the construction of the correlation and discriminant models. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-6-361-364DOI Listing
January 2018
1 Read

A model of clinical endometritis in Holstein heifers using pathogenic Escherichia coli and Trueperella pyogenes.

J Dairy Sci 2019 Mar 26;102(3):2686-2697. Epub 2019 Jan 26.

Department of Animal Sciences, University of Florida, Gainesville 32611. Electronic address:

Bacterial infection of the uterus causes clinical endometritis in 15 to 20% of postpartum dairy cows and reduces fertility, even after the resolution of disease. However, it is difficult to disentangle the mechanisms linking reduced fertility with endometritis because cows have multiple confounding postpartum conditions. The aim of the present experiment was to develop an in vivo model of clinical endometritis in Holstein heifers using pathogenic Escherichia coli and Trueperella pyogenes. Read More

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http://dx.doi.org/10.3168/jds.2018-15595DOI Listing
March 2019
2 Reads

Pro-inflammatory cytokine expression studies of subclinical and clinical endometritis in endometrial tissues of buffaloes.

Trop Anim Health Prod 2019 Jan 25. Epub 2019 Jan 25.

Department of Veterinary Microbiology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh, 362001, India.

The objective of the study was to investigate the role of pro-inflammatory cytokines in the pathogenesis of endometritis in buffaloes, which can lead to early diagnosis of endometritis. The expression of CD14, TLR-4, and IL-1β encoding gene in endometrium of buffaloes with subclinical endometritis were 1.87, 2. Read More

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http://dx.doi.org/10.1007/s11250-019-01802-8DOI Listing
January 2019
4 Reads

Correlation between hysteroscopy findings and chronic endometritis.

Fertil Steril 2019 Jan 22. Epub 2019 Jan 22.

Hysteroscopic Centre, Fu Xing Hospital, Capital Medical University, Beijing, People's Republic of China.

Objective: To evaluate the role of hysteroscopy in the diagnosis of chronic endometritis (CE).

Design: Retrospective cohort study.

Setting: University teaching hospital. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2018.12.007DOI Listing
January 2019
5 Reads

Nisin reduces uterine inflammation in rats by modulating the concentrations of the pro- and anti-inflammatory cytokines.

Am J Reprod Immunol 2019 Jan 25:e13096. Epub 2019 Jan 25.

College of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, P. R. China.

Problem: The Staphylococcus aureus has been found to be associated with clinical endometritis of cow. The result of oral antibiotic remains poor. Therefore, this study investigates the role of nisin in endometritis. Read More

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http://dx.doi.org/10.1111/aji.13096DOI Listing
January 2019
1 Read

[The development of diagnostic of acute endometritis on the basis of modeling and cluster analysis of parameters of local immunity.]

Klin Lab Diagn 2018 ;63(4):239-242

The Federal State Budget Educational Institution of Higher education "The Kursk State Medical University", 305041, Kursk, Russia.

The acute endometritis provoking expressed disorders of local immunity is considered as one of the prevalent complications of postnatal period and abortions. The purpose of study is to develop diagnostic of acute endometritis on the basis of applied correlation modeling and cluster analysis techniques diagnostically priority-driven immunological indices of vaginal cervical mucus. The sample included main group (154 patients with acute endometritis) and control group (103 patients with uncomplicated post-natal period). Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-4-239-242DOI Listing
January 2018
4 Reads

MiR-19a mediates the negative regulation of the NF-κB pathway in lipopolysaccharide-induced endometritis by targeting TBK1.

Inflamm Res 2019 Mar 23;68(3):231-240. Epub 2019 Jan 23.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China.

Objective: In both humans and animals, endometritis is severe inflammation of the uterus, and it causes great economic losses in dairy cow production. MicroRNAs have been reported to play an important role in various inflammatory diseases. However, the regulatory mechanisms of miR-19a in endometritis remain unclear. Read More

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http://link.springer.com/10.1007/s00011-019-01213-3
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http://dx.doi.org/10.1007/s00011-019-01213-3DOI Listing
March 2019
11 Reads

Protective Effects of Astragaloside IV against LPS-Induced Endometritis in Mice through Inhibiting Activation of the NF-κB, p38 and JNK Signaling Pathways.

Molecules 2019 Jan 21;24(2). Epub 2019 Jan 21.

College of Animal Sciences, Jilin University, Changchun, 5333 Xian Road, Changchun, Jilin 130062, China.

Endometritis, inflammation of the endometrium, is a common reproductive obstacle disease that can lead to infertility in female animals. Astragaloside IV (AS IV), one of the major and active components of the (Fisch.) Bunge, is known for its anti-inflammatory effects. Read More

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http://dx.doi.org/10.3390/molecules24020373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360020PMC
January 2019
2 Reads

The impact of mechanical cervical dilatation during elective cesarean section on postpartum scar integrity: a randomized double-blind clinical trial.

Int J Womens Health 2019 10;11:23-29. Epub 2019 Jan 10.

Department of Obstetrics & Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt,

Objective: The current study aimed to evaluate the impact of mechanical cervical dilatation during elective cesarean section (CS) on postpartum scar integrity at 6 months post operation.

Methods: A randomized double-blind clinical trial (UMIN000027946) was conducted at a tertiary university hospital in the period between July 1, 2017 and April 30, 2018. The study included pregnant women with a singleton fetus at term ≥37 weeks of gestation scheduled for elective CS. Read More

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http://dx.doi.org/10.2147/IJWH.S188628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330971PMC
January 2019
2 Reads

Relationship between Protein Oxidation Biomarkers and Uterine Health in Dairy Cows during the Postpartum Period.

Antioxidants (Basel) 2019 Jan 14;8(1). Epub 2019 Jan 14.

DSM Nutritional Products, 4303 Kaiseraugst, Switzerland.

High neutrophil (PMN, Polymorphonuclear neutrophil) counts in the endometrium of cows affected by endometritis, suggests the involvement of oxidative stress (OS) among the causes of impaired fertility. Protein oxidation, in particular, advanced oxidation protein products (AOPP), are OS biomarkers linked to PMN activity. To test this hypothesis, the relationship between protein oxidation and uterus health was studied in thirty-eight dairy cows during the puerperium. Read More

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http://www.mdpi.com/2076-3921/8/1/21
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http://dx.doi.org/10.3390/antiox8010021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356478PMC
January 2019
13 Reads

Adverse Maternal Outcomes Associated with Uterine Extensions at the Time of Cesarean Delivery.

Am J Perinatol 2019 Jan 15. Epub 2019 Jan 15.

Department of Obstetrics and Gynecology, Maternal and Child Health Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Objective:  We sought to compare adverse maternal outcomes between women with and without a uterine extension at the time of cesarean.

Study Design:  We conducted a retrospective cohort study of women with and without a uterine extension during a primary low transverse cesarean of a full-term singleton gestation. The primary outcomes were (1) estimated blood loss (EBL) and (2) composite maternal morbidity (defined as ≥ 1 of the following: blood transfusion, endometritis, or readmission). Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676827
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http://dx.doi.org/10.1055/s-0038-1676827DOI Listing
January 2019
9 Reads

Presence of gammaherpesvirus BoHV-4 in endometrial cytology samples is not associated with subclinical endometritis diagnosed at artificial insemination in dairy cows.

Vet Microbiol 2019 Feb 28;229:130-137. Epub 2018 Dec 28.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820, Merelbeke, Belgium. Electronic address:

In the past, bovine herpesvirus 4 (BoHV-4) has been suggested to be associated with metritis and endometritis. However, not many field studies investigated the association between BoHV-4 and subclinical endometritis (SCE). In the present study, the association between the intrauterine presence of BoHV-4 and SCE diagnosed during artificial insemination (AI) was examined on two dairy farms in Belgium. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781135183135
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http://dx.doi.org/10.1016/j.vetmic.2018.12.025DOI Listing
February 2019
9 Reads

Response to Letter to the Editor on " Coxiella burnetii in Infertile Dairy Cattle With Chronic Endometritis".

Vet Pathol 2019 Jan 13:300985818823781. Epub 2019 Jan 13.

1 Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1177/0300985818823781DOI Listing
January 2019
2 Reads

Delayed differentiation of vaginal and uterine microbiomes in dairy cows developing postpartum endometritis.

PLoS One 2019 10;14(1):e0200974. Epub 2019 Jan 10.

UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin, Ireland.

Bacterial overgrowth in the uterus is a normal event after parturition. In contrast to the healthy cow, animals unable to control the infection within 21 days after calving develop postpartum endometritis. Studies on the Microbial Ecology of the bovine reproductive tract have focused on either vaginal or uterine microbiomes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200974PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328119PMC
January 2019
2 Reads

TLR3 deficiency exacerbates the loss of epithelial barrier function during genital tract Chlamydia muridarum infection.

PLoS One 2019 9;14(1):e0207422. Epub 2019 Jan 9.

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

Problem: Chlamydia trachomatis infections are often associated with acute syndromes including cervicitis, urethritis, and endometritis, which can lead to chronic sequelae such as pelvic inflammatory disease (PID), chronic pelvic pain, ectopic pregnancy, and tubal infertility. As epithelial cells are the primary cell type productively infected during genital tract Chlamydia infections, we investigated whether Chlamydia has any impact on the integrity of the host epithelial barrier as a possible mechanism to facilitate the dissemination of infection, and examined whether TLR3 function modulates its impact.

Method Of Study: We used wild-type and TLR3-deficient murine oviduct epithelial (OE) cells to ascertain whether C. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207422PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326510PMC
January 2019
8 Reads

Effects of antibiotic therapy in women with the amniotic fluid "sludge" at 15-24 weeks of gestation on pregnancy outcomes.

Authors:
Olga Pustotina

J Matern Fetal Neonatal Med 2019 Jan 27:1-12. Epub 2019 Jan 27.

a Obstetrics, Gynecology and Perinatology , Peoples' Friendship University of Russia , Moscow , Russia.

Objective: The aim of this prospective study was to assess the efficacy of antibiotic therapy for the prevention of adverse pregnancy outcomes in women with the amniotic fluid "sludge" at 15-24 weeks of gestation.

Methods: 245 women underwent transvaginal ultrasound cervical length measurement at 15-24 weeks of pregnancy and 29 out of them with amniotic fluid "sludge" were included in the study. Eight women with the "sludge" had cervical length >25 mm (Group I), seven-an asymptomatic short cervix (Group IIa) and 14 women with a short cervix had symptoms like low abdominal pain, back pain, and menstrual-like cramps (Group IIb). Read More

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http://dx.doi.org/10.1080/14767058.2019.1567706DOI Listing
January 2019
2 Reads

Corrigendum to "Endometrial expression of the acute phase molecule SAA is more significant than HP in reflecting the severity of endometritis" [Research in Veterinary Science 121 (2018) 130-133].

Res Vet Sci 2019 Jan 3;123:111. Epub 2019 Jan 3.

Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Key Laboratory of Veterinary Pharmaceutics Discovery of Agriculture Ministry, Lanzhou 730050, China.

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http://dx.doi.org/10.1016/j.rvsc.2018.12.019DOI Listing
January 2019
2 Reads

Endometrial TGF-β, IL-10, IL-17 and autophagy are dysregulated in women with recurrent implantation failure with chronic endometritis.

Reprod Biol Endocrinol 2019 Jan 3;17(1). Epub 2019 Jan 3.

Reproductive Medicine and Immunology, Department of Obstetrics and Gynecology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 830 West Court, Suite 400, Vernon Hills, IL, 60061, USA.

Background: Chronic endometritis (CE) is a condition which results in reduced receptivity of embryos by dysregulated lymphocyte subsets, abnormal expression of cytokines, chemokines and other regulatory molecules in the endometrium (EM). Macroautophagy (autophagy), the highly conserved cellular homeostasis pathway, plays an essential role in the development and function of T lymphocytes, and supports T cell lineage stability and survival fitness. The possible relationships between autophagy and local cytokine milieus in repeated implantation failure (RIF) with CE have not been elucidated yet. Read More

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https://rbej.biomedcentral.com/articles/10.1186/s12958-018-0
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http://dx.doi.org/10.1186/s12958-018-0444-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317248PMC
January 2019
6 Reads
2.409 Impact Factor

New models of lipopolysaccharide-induced implantation loss reveal insights into the inflammatory response.

Am J Reprod Immunol 2019 Jan 2:e13082. Epub 2019 Jan 2.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.

Problem: Chronic endometritis, inflammation of the uterizzvvne lining caused by common gram-negative bacterial strains or mycoplasma, has been associated with unexplained implantation failure and infertility. However, limited models of bacteria-induced implantation loss exist to study the molecular changes that occur in vivo. The goal of this study was to provide a new resource to study the process of bacteria-induced inflammation and implantation loss utilizing common experimental models: C57Bl/6 mice and primary human endometrial stromal cells. Read More

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http://doi.wiley.com/10.1111/aji.13082
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http://dx.doi.org/10.1111/aji.13082DOI Listing
January 2019
5 Reads

A Holstein-Friesian dairy farm survey of postparturient factors influencing the days to first AI and days open in Hungary.

Acta Vet Hung 2018 Dec;66(4):613-624

1 University of Veterinary Science, Department and Clinic for Production Animals , H-2225 Üllő, Dóra major , Hungary.

The authors monitored the postpartum period during the first seven weeks after calving at a Holstein-Friesian dairy farm in Hungary. Calvings occurred between 2013 and 2015 in three periods from June to November each year (n = 314). Data were collected from the farm record and ultrasonographic examinations were performed between 22 to 28 and 43 to 49 days in milk (DIM), respectively. Read More

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http://dx.doi.org/10.1556/004.2018.054DOI Listing
December 2018
2 Reads

Cost-effectiveness of antibiotic prophylaxis in elective cesarean section.

Cost Eff Resour Alloc 2018 18;16:66. Epub 2018 Dec 18.

5University Health Care Research Center, Faculty of Medicine and Health, Örebro University, 701 85 Örebro, Sweden.

Background: The proportion of pregnant women delivered by cesarean section has increased steadily during the past three decades. The risk of infection is 10-fold augmented after elective cesarean section compared to vaginal delivery. Antibiotic prophylaxis may reduce endometritis by 62% and superficial wound infection by 38% after elective cesarean section. Read More

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http://dx.doi.org/10.1186/s12962-018-0168-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299592PMC
December 2018
3 Reads

Re: "Coxiella burnetii in Infertile Dairy Cattle With Chronic Endometritis".

Authors:
Rebecca J Egan

Vet Pathol 2018 Dec 17:300985818819231. Epub 2018 Dec 17.

1 University of Guelph, Ontario, Canada.

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http://dx.doi.org/10.1177/0300985818819231DOI Listing
December 2018
2 Reads

Preterm Prelabor Rupture of Membranes: Outcomes with Expectant Management until 34 versus 35 Weeks.

Am J Perinatol 2018 Dec 15. Epub 2018 Dec 15.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York.

Objective:  To evaluate outcomes with expectant management of preterm prelabor rupture of membranes (PROM) until 35 weeks versus immediate delivery at ≥34 weeks.

Study Design:  This was a multicenter retrospective cohort study of singletons with preterm PROM at >20 weeks from 2011 through 2017. Groups were defined as expectant management until 35 weeks versus immediate delivery at ≥34 weeks. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1675647
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http://dx.doi.org/10.1055/s-0038-1675647DOI Listing
December 2018
9 Reads

Characterization of cytokine gene expression in uterine cytobrush samples of non-endometritic versus endometritic postpartum dairy cows.

Theriogenology 2019 Mar 5;126:128-139. Epub 2018 Dec 5.

Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, S7N 5B4, Canada.

To better understand uterine inflammation in postpartum dairy cows we collected sequential cytobrush samples at 29-35 and at 49-55 d in milk (DIM). Based on the uterine cytology, cows were classified as Non-endometritic (n = 23; <18% neutrophils) or Endometritic (n = 12; ≥18% neutrophils) at 29-35 DIM and Non-endometritic (n = 17; <10% neutrophils) or Endometritic (n = 9; ≥10% neutrophils) at 49-55 DIM. Cows defined as Sham Controls (n = 6) were examined by vaginoscopy at 29-35 DIM and identified as Non-endometritic (<10% neutrophils) at 49-55 DIM. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2018.12.011DOI Listing

Structural uterine changes in postpartum endometritis in cows.

Vet World 2018 Nov 22;11(10):1473-1478. Epub 2018 Oct 22.

Department of Agrobiotechnology, Agrarian Technological Institute, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.

Aim: The purpose of this work was to study the dynamics of structural manifestations of acute cases of postpartum endometritis in cows.

Materials And Methods: The light and electron microscopy methods were used when studying structural changes in the endometrium in case of postpartum endometritis in seven cows. Sections of endometrial specimens for light microscopy, 5-7 µm thick, were stained with hematoxylin and eosin and also by Van Gieson's. Read More

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http://dx.doi.org/10.14202/vetworld.2018.1473-1478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247873PMC
November 2018
5 Reads

Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions.

Reprod Biol Endocrinol 2018 Dec 5;16(1):121. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat Gan, Israel.

Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age and embryo stage into consideration. The failure of embryo implantation can be a consequence of uterine, male, or embryo factors, or the specific type of IVF protocol. Read More

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http://dx.doi.org/10.1186/s12958-018-0414-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282265PMC
December 2018
3 Reads

Efficient treatment of chronic endometritis through a novel approach of intrauterine antibiotic infusion: a case series.

BMC Womens Health 2018 12 5;18(1):197. Epub 2018 Dec 5.

Centre for Human Reproduction, Genesis Athens Clinic, 14-16, Papanikoli 15232, Athens, Greece.

Background: Early diagnosis and efficient management of Chronic Endometritis (CE) in patients seeking fertility treatment are two components every practitioner wishes to address. With respect to endometrial restoration, antibiotic treatment appears to perform well. However, regarding the improvement of In Vitro Fertilization (IVF) success rates, literature evidence is inconclusive, and consensus on optimal treatment has yet to be reached. Read More

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http://dx.doi.org/10.1186/s12905-018-0688-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280440PMC
December 2018
4 Reads

Using the Probability of Cesarean from a Validated Cesarean Prediction Calculator to Predict Labor Length and Morbidity.

Am J Perinatol 2018 Dec 3. Epub 2018 Dec 3.

Maternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Objective:  To determine if increasing predicted risk of cesarean was associated with longer labor length and increased morbidity among women undergoing induction with an unfavorable cervix.

Study Design:  Using a publically available database, we evaluated whether a previously validated prediction model for cesarean delivery after induction was associated with labor length, maternal morbidity (third-/fourth-degree lacerations, endometritis, blood transfusion, wound infection, venous thromboembolism, hysterectomy, intensive care unit admission, and death), and neonatal morbidity (blood transfusion, encephalopathy, intraventricular hemorrhage, severe respiratory distress syndrome, necrotizing enterocolitis, and sepsis). Full-term (≥37 weeks) singleton gestations with intact membranes and an unfavorable cervix (Bishop score ≤6 and dilation ≤2 cm) undergoing induction of labor were included. Read More

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http://dx.doi.org/10.1055/s-0038-1675625DOI Listing
December 2018
5 Reads

Histological Pattern of Endometrial Biopsies in Women with Abnormal Uterine Bleeding in a Hospital in North Central Nigeria.

Int J Reprod Med 2018 1;2018:2765927. Epub 2018 Nov 1.

Department of Morbid Anatomy & Forensic Medicine, Obafemi Awolowo University, Ile-Ife 220282, Nigeria.

The study is a retrospective cross-sectional study carried out in the Department of Pathology of Premier Hospital, Abuja, on specimens received over a one-year period. Four hundred and eighty-six samples of endometrial biopsies and curettings from women presenting with abnormal uterine bleeding sent to the histopathology laboratory were analyzed. The most common biopsies were those of product of conception which accounted for 304 cases (62. Read More

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http://dx.doi.org/10.1155/2018/2765927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236767PMC
November 2018
4 Reads

Evidence-based interventions to reduce obstetric-related infections at an army training facility.

Am J Infect Control 2018 Nov 30. Epub 2018 Nov 30.

Department of Obstetrics and Gynecology, Tripler Army Medical Center, Honolulu, HI.

Objective: Obstetric-related infections are a major cause of maternal morbidity and mortality worldwide. Our team implemented an evidence-based infection control bundle aimed at reducing obstetric-related infections at our facility.

Methods: A multidisciplinary team at Tripler Army Medical Center developed, implemented, and evaluated an evidence-based maternal safety infection control bundle (MSICB) on labor and delivery aimed at reducing the incidence of surgical site infections (SSI) and chorioamnionitis. Read More

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http://dx.doi.org/10.1016/j.ajic.2018.09.023DOI Listing
November 2018

Azithromycin-based Extended-Spectrum Antibiotic Prophylaxis for Cesarean: Role of Placental Colonization with Genital Ureaplasmas and Mycoplasmas.

Am J Perinatol 2018 Nov 30. Epub 2018 Nov 30.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama.

Objective:  To explore whether the effect of azithromycin (AZI) on postcesarean infections varied by the presence/absence of genital mycoplasmataceae placental colonization.

Materials And Methods:  This was a single-center substudy of multicenter double-blind C/SOAP (Cesarean Section Optimal Antibiotic Prophylaxis) trial of women randomized to AZI or placebo (+cefazolin) antibiotic prophylaxis at cesarean. Chorioamnion/placenta specimens were tested for genital mycoplasmataceae colonization by polymerase chain reaction. Read More

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http://dx.doi.org/10.1055/s-0038-1675766DOI Listing
November 2018
18 Reads

Recurrent group A streptococcal severe sepsis in the postpartum period.

Int J Gynaecol Obstet 2019 Feb 13;144(2):235-236. Epub 2018 Dec 13.

Transbaikal Regional Hospital, Chita, Russia.

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http://dx.doi.org/10.1002/ijgo.12725DOI Listing
February 2019
2 Reads

Association of chorioamnionitis and its duration with adverse maternal outcomes by mode of delivery: a cohort study.

BJOG 2018 Nov 28. Epub 2018 Nov 28.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA.

Objective: To investigate the association of chorioamnionitis and its duration with adverse maternal outcomes by mode of delivery.

Design: A retrospective cohort study.

Setting: Data from the Consortium on Safe Labor Study in the USA (2002-2008). Read More

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http://dx.doi.org/10.1111/1471-0528.15565DOI Listing
November 2018
3 Reads