5,530 results match your criteria Endometritis


Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions.

Reprod Biol Endocrinol 2018 Dec 5;16(1):121. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat Gan, Israel.

Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age and embryo stage into consideration. The failure of embryo implantation can be a consequence of uterine, male, or embryo factors, or the specific type of IVF protocol. Read More

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December 2018

Efficient treatment of chronic endometritis through a novel approach of intrauterine antibiotic infusion: a case series.

BMC Womens Health 2018 Dec 5;18(1):197. Epub 2018 Dec 5.

Centre for Human Reproduction, Genesis Athens Clinic, 14-16, Papanikoli 15232, Athens, Greece.

Background: Early diagnosis and efficient management of Chronic Endometritis (CE) in patients seeking fertility treatment are two components every practitioner wishes to address. With respect to endometrial restoration, antibiotic treatment appears to perform well. However, regarding the improvement of In Vitro Fertilization (IVF) success rates, literature evidence is inconclusive, and consensus on optimal treatment has yet to be reached. Read More

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December 2018

Using the Probability of Cesarean from a Validated Cesarean Prediction Calculator to Predict Labor Length and Morbidity.

Am J Perinatol 2018 Dec 3. Epub 2018 Dec 3.

Maternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Objective:  To determine if increasing predicted risk of cesarean was associated with longer labor length and increased morbidity among women undergoing induction with an unfavorable cervix.

Study Design:  Using a publically available database, we evaluated whether a previously validated prediction model for cesarean delivery after induction was associated with labor length, maternal morbidity (third-/fourth-degree lacerations, endometritis, blood transfusion, wound infection, venous thromboembolism, hysterectomy, intensive care unit admission, and death), and neonatal morbidity (blood transfusion, encephalopathy, intraventricular hemorrhage, severe respiratory distress syndrome, necrotizing enterocolitis, and sepsis). Full-term (≥37 weeks) singleton gestations with intact membranes and an unfavorable cervix (Bishop score ≤6 and dilation ≤2 cm) undergoing induction of labor were included. Read More

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December 2018

Histological Pattern of Endometrial Biopsies in Women with Abnormal Uterine Bleeding in a Hospital in North Central Nigeria.

Int J Reprod Med 2018 1;2018:2765927. Epub 2018 Nov 1.

Department of Morbid Anatomy & Forensic Medicine, Obafemi Awolowo University, Ile-Ife 220282, Nigeria.

The study is a retrospective cross-sectional study carried out in the Department of Pathology of Premier Hospital, Abuja, on specimens received over a one-year period. Four hundred and eighty-six samples of endometrial biopsies and curettings from women presenting with abnormal uterine bleeding sent to the histopathology laboratory were analyzed. The most common biopsies were those of product of conception which accounted for 304 cases (62. Read More

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November 2018

Evidence-based interventions to reduce obstetric-related infections at an army training facility.

Am J Infect Control 2018 Nov 30. Epub 2018 Nov 30.

Department of Obstetrics and Gynecology, Tripler Army Medical Center, Honolulu, HI.

Objective: Obstetric-related infections are a major cause of maternal morbidity and mortality worldwide. Our team implemented an evidence-based infection control bundle aimed at reducing obstetric-related infections at our facility.

Methods: A multidisciplinary team at Tripler Army Medical Center developed, implemented, and evaluated an evidence-based maternal safety infection control bundle (MSICB) on labor and delivery aimed at reducing the incidence of surgical site infections (SSI) and chorioamnionitis. Read More

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November 2018

Azithromycin-based Extended-Spectrum Antibiotic Prophylaxis for Cesarean: Role of Placental Colonization with Genital Ureaplasmas and Mycoplasmas.

Am J Perinatol 2018 Nov 30. Epub 2018 Nov 30.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama.

Objective:  To explore whether the effect of azithromycin (AZI) on postcesarean infections varied by the presence/absence of genital mycoplasmataceae placental colonization.

Materials And Methods:  This was a single-center substudy of multicenter double-blind C/SOAP (Cesarean Section Optimal Antibiotic Prophylaxis) trial of women randomized to AZI or placebo (+cefazolin) antibiotic prophylaxis at cesarean. Chorioamnion/placenta specimens were tested for genital mycoplasmataceae colonization by polymerase chain reaction. Read More

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November 2018
3 Reads

Recurrent group A streptococcal severe sepsis in the postpartum period.

Int J Gynaecol Obstet 2018 Nov 29. Epub 2018 Nov 29.

Transbaikal Regional Hospital, Chita, Russia.

This report presents the relapse and treatment of streptococcal infection in the postpartum period in a patient with severe group A streptococcal sepsis. Maternal sepsis was estimated to cause around 10.7% of maternal deaths worldwide between 2003 and 2009 [1]. Read More

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November 2018
1 Read

Association of chorioamnionitis and its duration with adverse maternal outcomes by mode of delivery: a cohort study.

BJOG 2018 Nov 28. Epub 2018 Nov 28.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina (Chapel Hill, NC).

Objective: To investigate the association of chorioamnionitis and its duration with adverse maternal outcomes by mode of delivery.

Design: A retrospective cohort study.

Setting: Data from the Consortium on Safe Labor Study (CSL) in the USA (2002-2008). Read More

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November 2018
1 Read

Prostaglandin E promotes Pam3CSK4-induced inflammation in endometrial epithelial cells of cattle.

Anim Reprod Sci 2018 Nov 20. Epub 2018 Nov 20.

Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, No. 306, Zhaowuda Road, Saihan District, 010018, Hohhot, China; Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, Inner Mongolia Agricultural University, No. 306, Zhaowuda Road, Saihan District, 010018, Hohhot, China. Electronic address:

Bacterial contamination often impairs uterine function in cattle leading to uterine diseases such as endometritis. Inflammatory responses to bacterial infections in the uterus of cattle are generated through pattern recognition receptors, including Toll-like receptor 2 (TLR2), which is responsible for Pam3CSK4 recognition. This cellular response induces inflammatory responses through stimulation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB signaling activation, stimulating the expression of inflammatory mediators. Read More

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November 2018

Multiple Myeloma 1 Transcription Factor Is Superior to CD138 as a Marker of Plasma Cells in Endometrium.

Int J Surg Pathol 2018 Nov 28:1066896918814307. Epub 2018 Nov 28.

1 University of California, Los Angeles, CA, USA.

Chronic endometritis is characterized by plasma cell (PC) infiltration of endometrial stroma. Identification of PCs can be challenging by routine hematoxylin and eosin (H&E) stain due to the low numbers of PCs or to their being obscured by other cells in the stroma. CD138 is widely used as an ancillary immunohistochemistry stain to identify PCs; however, it has a high background reaction. Read More

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November 2018
1 Read

Uterine Microbiota of Dairy Cows With Clinical and Subclinical Endometritis.

Front Microbiol 2018 6;9:2691. Epub 2018 Nov 6.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, China.

The objective of this study was to characterize the uterine microbiota of dairy cows with clinical and subclinical endometritis and to identify the potential bacterial genera as well as their interactions associated with uterine disease. Uterine flush samples ( = 27) were collected from 13 healthy, 5 subclinical endometritic (SE), and 9 clinical endometritic (CE) cows at 30 days postpartum. Microbial DNA from uterine flush samples was subjected to sequencing of the 16S rRNA gene on the Illumina MiSeq platform. Read More

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November 2018
4 Reads

Vaginal cleansing prior to caesarian section: To do or not to do?: A randomized trial.

J Gynecol Obstet Hum Reprod 2018 Nov 14. Epub 2018 Nov 14.

Faculty of Medicine, Taif University, Saudi Arabia. Electronic address:

Purpose: To evaluate the efficacy of preoperative vaginal cleansing using povidone-iodine solution 10% on rates of post cesarean section (CS) infectious morbidities (endometritis, febrile morbidity and wound infection).

Methods: This prospective randomized trial was conducted among 226 pregnant women scheduled for term elective CS. Patients were equally divided into two groups by simple randomization method. Read More

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November 2018
1 Read

Different regimens of penicillin antibiotics given to women routinely for preventing infection after cesarean section: A systematic review and meta analysis.

Medicine (Baltimore) 2018 Nov;97(46):e11889

Cochrane China, West China Hospital, Sichuan University, Chengdu, China.

Background: Varied regimens of penicillin antibiotics were given to women for preventing infection after cesarean section, but there is no study compares the effectiveness and safety of them.

Methods: We searched MEDLINE, Embase, CENTRAL, CNKI, Wanfang, VIP, and CBM Database, and contacted experts in the field and searched reference lists of retrieved studies. We included randomized controlled trials comparing different regimens of penicillin antibiotics given to women after cesarean section. Read More

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November 2018
1 Read

Luteolin Showed a Resistance Elimination Effect on Gentamicin by Decreasing MATE mRNA Expression in Trueperella pyogenes.

Microb Drug Resist 2018 Nov 15. Epub 2018 Nov 15.

Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University , Shenyang, P.R. China .

Trueperella pyogenes is a common inhabitant of mucosal surfaces in animals and causes a variety of infections, including endometritis, mastitis, and liver abscessation, in dairy cows. Many antimicrobial agents are used for treatment of infections caused by T. pyogenes; however, antibiotic resistance has recently become a serious problem. Read More

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November 2018
5 Reads

Bilateral salpingectomy versus bilateral partial salpingectomy during cesarean delivery.

Int J Womens Health 2018 23;10:649-653. Epub 2018 Oct 23.

Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA,

Objective: To compare surgical outcomes in patients undergoing bilateral salpingectomy (salpingectomy group) with those who had partial salpingectomy (partial salpingectomy group) during cesarean delivery.

Materials And Methods: A chart review from July 2015 to November 2016 was performed. We included women who had sterilization during cesarean delivery. Read More

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October 2018
11 Reads

Assessing Maternal and Fetal Risks Associated with Prolonged Induction of Labor.

Am J Perinatol 2018 Nov 10. Epub 2018 Nov 10.

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.

Objective:  To assess whether prolonged induction of labor was associated with increased maternal or neonatal morbidity.

Study Design:  We performed a retrospective cohort study of women undergoing induction of labor at a single institution. We included women with singletons ≥ 36 weeks with initial cervical dilation ≤4 cm. Read More

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November 2018
15 Reads

Endometrial expression of the acute phase molecule SAA is more significant than HP in reflecting the severity of endometritis.

Res Vet Sci 2018 Dec 30;121:130-133. Epub 2018 Oct 30.

Chinese Academy of Agricultural Sciences, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Lanzhou 730050, China. Electronic address:

This study investigated the correlation between endometrial local expressions of serum amyloid A (SAA) and haptoglobin (Hp) and severity of endometritis in 20 Chinese Holstein dairy cows at 40-60 days postpertum, aged 3-6, and 2-5 parities. Endometrial biopsies were collected and categorized into normal, mild endometritis, and severe endometritis based on clinical signs and histopathology. The protein and mRNA expression of SAA and Hp in endometrial tissue were measured using western blot and real-time PCR, respectively. Read More

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December 2018
6 Reads

MicroRNA let-7c Improves LPS-Induced Outcomes of Endometritis by Suppressing NF-κB Signaling.

Inflammation 2018 Nov 8. Epub 2018 Nov 8.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China.

Endometritis is a common inflammatory disease which endangers human and animal reproductive health. MicroRNA (miRNA) let-7c plays an important role in the inflammatory process; however, the regulatory underlying mechanism of let-7c in endometritis is unclear. In this study, we confirmed that let-7c was significantly reduced in LPS-induced mouse endometritis model, and overexpression of let-7c was able to effectively reduce uterine tissue damage caused by lipopolysaccharide (LPS), and then, a LPS-induced bovine endometrial epithelial cell (BEND) line was used to mimic the inflammatory model in vitro. Read More

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November 2018
2 Reads

Extended lactation in high-yielding dairy cows. II. Effects on milk production, udder health, and body measurements.

J Dairy Sci 2018 Oct 31. Epub 2018 Oct 31.

Department for Farm Animals, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.

The objective of this prospective field study was to evaluate the effects of extending the lactation period of high-yielding dairy cows on milk production, udder health characteristics, and development of body condition. On 40 d in milk (DIM), an examination of the genital tract (transrectal palpation, sonography, vaginoscopy) was performed. Cows without signs of clinical endometritis were blocked by parity and were randomly allocated to 1 of 3 experimental groups with a voluntary waiting period of 40, 120, and 180 d, respectively (G40, n = 135; G120, n = 141; G180, n = 139). Read More

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October 2018
1 Read

Extended lactation in high-yielding dairy cows. I. Effects on reproductive measurements.

J Dairy Sci 2018 Oct 31. Epub 2018 Oct 31.

Department for Farm Animals, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.

The objective of this prospective field study was to evaluate the effects of extending the lactation period on various reproductive measurements of high-yielding Holstein cows. On 40 d in milk (DIM), cows were gynecologically examined (transrectal palpation, sonography, vaginoscopy). Cows without signs of clinical endometritis were blocked by parity and were randomly allocated to 1 of 3 experimental groups with a voluntary waiting period (VWP) of 40, 120, and 180 d, respectively (G40, n = 135; G120, n = 141; G180, n = 139). Read More

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October 2018
1 Read

Xanthogranulomatous endometritis mimicking endometrial carcinoma: A case report and review of literature.

Radiol Case Rep 2019 Jan 26;14(1):121-125. Epub 2018 Oct 26.

Department Head, CT and MRI, Health Sciences Centre, Department of Radiology, University of Manitoba, GA220-820 Sherbrook Street, Winnipeg, Manitoba R3A1R9, Canada.

Xanthogranulomatous endometritis (XGE) is an extremely rare chronic inflammatory condition, which may be associated with endometrial hyperplasia, endometrial carcinoma, or cervical stenosis. Imaging features can be easily misdiagnosed as an aggressive malignancy. We present a case of XGE, which is the first case of XGE with serial multimodality imaging examinations, in addition to clinical, surgical and pathologic correlations. Read More

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January 2019
4 Reads

Postpartum Invasive Group A Streptococcus Infection: Case Report and Mini-review.

Cureus 2018 Aug 22;10(8):e3184. Epub 2018 Aug 22.

Infectious Diseases, Creighton University Medical Center, Omaha, USA.

The overall incidence of postpartum invasive group A streptococcal (GAS) disease is low in the United States. However, postpartum women are much more likely to develop GAS disease than nonpregnant women. Additionally, postpartum GAS has the potential to develop into a severe disease and a delay in diagnosis can have deadly consequences. Read More

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August 2018
1 Read

Tolerance and Innate Immunity Shape the Development of Postpartum Uterine Disease and the Impact of Endometritis in Dairy Cattle.

Annu Rev Anim Biosci 2018 Oct 25. Epub 2018 Oct 25.

Department of Animal Sciences, University of Florida, Gainesville, Florida 32611-0910, USA; email:

Bacteria are ubiquitous in the bovine uterus after parturition, but 50 years ago, cows tolerated these bacteria and few animals developed uterine disease. Now, up to 40% of dairy cattle develop postpartum uterine disease. Uterine disease causes infertility by compromising the function of not only the endometrium but also the ovary. Read More

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October 2018
6 Reads

Reproducibility of endometrial cytology using cytobrush technique and agreement for the diagnosis of subclinical endometritis between five predefined endometrial sites.

Reprod Domest Anim 2018 Oct 24. Epub 2018 Oct 24.

Clinical Unit for Herd Health Management in Ruminants, University Clinic for Ruminants, University of Veterinary Medicine, Vienna, Austria.

The objectives of this study were as follows: (a) to assess the reproducibility of polymorphonuclear neutrophil (PMN) cell counts at five predefined endometrial sites (corpus uteri, left horn base, right horn base, left horn tip and right horn tip) and (b) to determine the agreement for the diagnosis of subclinical endometritis (SE) between the different endometrial sites. Forty milking cows between 28 and 34 days post-partum were enrolled for endometrial sampling using cytobrush technique. Intraclass correlation coefficient (ICC) was calculated to evaluate the reproducibility of PMN counts at different sites. Read More

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October 2018
1 Read

Comparative therapeutic efficacy of levofloxacin, ornidazole and alpha tocopherol combination with prostaglandin F2α on and transcript level in longstanding cases of endometritis in crossbreed Jersey cows.

Iran J Vet Res 2018 ;19(3):217-224

Department of Animal Reproduction, Gynaecology and Obstetrics, College of Veterinary Science & Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar, 751003, India.

This study compared the therapeutic efficacy of levofloxacin, ornidazole and alpha tocopherol combination and prostaglandin F2α (PGF2α) in longstanding cases of endometritis and evaluated their impact on () and () transcript level in peripheral blood leukocytes. Eighteen endometritic crossbred Jersey cows were randomly allotted to three groups (six in each) Group I (levofloxacin combo treatment I/U), group II (PGF2α treatment I/M), group III (no treatment, control), and group IV (six non-endometritic healthy cyclic) was taken for comparison study. The clinical efficacy was assessed by haematological study (TLC: Total leukocyte count; DC: Differential count), polymorphonuclear leukocytes (PMN) count in uterine cytology and relative mRNA expression of and in peripheral blood leukocytes before and after treatment with respect to conception rate following single and second inseminations. Read More

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January 2018
6 Reads

Skin preparation for preventing infection following caesarean section.

Cochrane Database Syst Rev 2018 10 22;10:CD007462. Epub 2018 Oct 22.

Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, DR.Sardjito Hospital, Jl. Kesehatan No.1, Sekip, Yogyakarta, Daerah Istimewa Yogyakarta, Indonesia, 55281.

Background: The risk of maternal mortality and morbidity (particularly postoperative infection) is higher for caesarean section (CS) than for vaginal birth. With the increasing rate of CS, it is important to minimise the risks to the mother as much as possible. This review focused on different forms and methods of preoperative skin preparation to prevent infection. Read More

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October 2018
7 Reads

Effects of dry period length on metabolic status, fertility, udder health, and colostrum production in 2 cow breeds.

J Dairy Sci 2018 Oct 18. Epub 2018 Oct 18.

Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden.

Shortening the dry period improves postpartum energy balance, which has potential positive effects on metabolic health. This concept has been mainly studied in Holstein cows. The aim of this study was to assess the effect of a short dry period of 4 wk, compared with a standard dry period of 8 wk, on the metabolic status, progesterone profiles, health, and colostrum quality of dairy cows of 2 breeds, Swedish Red (SR) and Swedish Holstein (SH), not treated with antibiotics at dry off. Read More

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October 2018

A functional role for AMPK in female fertility and endometrial regeneration

Reproduction 2018 Sep 12. Epub 2018 Sep 12.

Department of Animal Sciences, Center for Reproductive Biology, Washington State University, Pullman, Washington, USA

Adenosine monophosphate-activated protein kinase (AMPK) is a highly conserved heterotrimeric complex that acts as an intracellular energy sensor. Based on recent observations of AMPK expression in all structures of the female reproductive system, we hypothesized that AMPK is functionally required for maintaining fertility in the female. This hypothesis was tested by conditionally ablating the two catalytic alpha subunits of AMPK, Prkaa1 and Prkaa2, using Pgr-cre mice. Read More

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September 2018
4 Reads

Clinical efficacy of intrauterine cephapirin benzathine administration on clearance of uterine bacteria and subclinical endometritis in postpartum buffaloes.

Reprod Domest Anim 2018 Oct 16. Epub 2018 Oct 16.

ICAR-Central Institute for Research on Buffaloes, sub-Campus Nabha, Patiala, Punjab, India.

This study examined the effect of single IU administration of cephapirin on clinical recovery, clearance of uterine bacteria and reproductive performance of postpartum buffaloes with subclinical endometritis (SCE). Buffaloes (n = 86) at 35 days postpartum (DPP) with >10% polymorphonuclear (PMN) cells in endometrial cytosmears were designated as positive (SCEP, n = 29), and buffaloes with ≤10% PMN cell were designated as negative (SCEN, n = 57) for SCE. Out of 29 positive buffaloes, 15 were administered a single intrauterine dose of cephapirin benzathine on 40 DPP (SCEP-CB), while the remaining 14 animals were kept as untreated control (SCEP-C). Read More

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October 2018
9 Reads

The effect of mechanical cervical dilatation during scheduled cesarean section on the blood loss: a randomized controlled trial.

J Matern Fetal Neonatal Med 2018 Oct 15:1-11. Epub 2018 Oct 15.

b Department of Obstetrics & Gynecology , Faculty of Medicine , Assiut University , Assiut , Egypt.

Objective: This study evaluates the effects of mechanical cervical dilatation during scheduled cesarean section (CS) on intra- and postoperative blood loss.

Methods: A single-center randomized double-blind controlled trial ( NCT03444792 ) conducted at a tertiary University Hospital in the period between 1 April 2017 and 31 March 2018 included all women scheduled for scheduled CS under spinal anesthesia if they met our inclusion criteria. Eligible participants were randomized to one of two groups. Read More

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October 2018
3 Reads

Effects of pegbovigrastim administration on periparturient diseases, milk production, and reproductive performance of Holstein cows.

J Dairy Sci 2018 Dec 11;101(12):11199-11217. Epub 2018 Oct 11.

Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY 14853-6401. Electronic address:

The aim of this study was to evaluate the effects of treating Holstein cows with pegbovigrastim on periparturient diseases, milk production, and reproductive performance while exploring the mode of action of an immunomodulatory protein. Cows were randomly allocated to 1 of 2 treatments, untreated control (CTR, n = 423) and pegbovigrastim (PEG, n = 417). At 7 d from the anticipated calving date (d -7), cows allocated to PEG received a subcutaneous injection of 15 mg of pegylated recombinant bovine granulocyte colony stimulating factor (pegbovigrastim injection, Imrestor, Elanco Animal Health, Greenfield, IN). Read More

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December 2018
2 Reads

Effect of Immediate vs Delayed Pushing on Rates of Spontaneous Vaginal Delivery Among Nulliparous Women Receiving Neuraxial Analgesia: A Randomized Clinical Trial.

JAMA 2018 10;320(14):1444-1454

Department of Obstetrics and Gynecology, School of Medicine, Washington University in St Louis, St Louis, Missouri.

Importance: It is unclear whether the timing of second stage pushing efforts affects spontaneous vaginal delivery rates and reduces morbidities.

Objective: To evaluate whether immediate or delayed pushing results in higher rates of spontaneous vaginal delivery and lower rates of maternal and neonatal morbidities.

Design, Setting, And Participants: Pragmatic randomized clinical trial of nulliparous women at or beyond 37 weeks' gestation admitted for spontaneous or induced labor with neuraxial analgesia between May 2014 and December 2017 at 6 US medical centers. Read More

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October 2018
15 Reads

[Prevalence of Chlamydia trachomatis in pregnant women during the first trimester in a private institution in Córdoba.]

Rev Fac Cien Med Univ Nac Cordoba 2018 09 20;75(3):183-188. Epub 2018 Sep 20.

Clínica Reina Fabiola ciudad de Córdoba.

Introduction: The presence of C. trachomatis in pregnant women can cause premature rupture of membranes, postpartum endometritis and preterm birth. Clinical diagnosis is more difficult among those who have an asymptomatic infection. Read More

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September 2018
3 Reads

Gene Expression Signatures Can Aid Diagnosis of Sexually Transmitted Infection-Induced Endometritis in Women.

Front Cell Infect Microbiol 2018 20;8:307. Epub 2018 Sep 20.

Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Sexually transmitted infection (STI) of the upper reproductive tract can result in inflammation and infertility. A biomarker of STI-induced upper tract inflammation would be significant as many women are asymptomatic and delayed treatment increases risk of sequelae. Blood mRNA from 111 women from three cohorts was profiled using microarray. Read More

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September 2018
2 Reads

Effect of equine chorionic gonadotropin administration on day 8 post-partum on ovarian follicular development, uterine health and uterine involution in lactating dairy cows.

Theriogenology 2019 Jan 27;123:54-61. Epub 2018 Sep 27.

Animal and Grassland Research and Innovation Centre, Teagasc, Moorepark, Fermoy, Co. Cork, Ireland. Electronic address:

The objective was to evaluate the effect of equine chorionic gonadotropin (eCG) injection on day 8 postpartum on ovarian cyclicity, uterine health and uterine involution in lactating dairy cows. Lactating dairy cows [n = 34, (21 primiparous and 13 multiparous)] were enrolled in the study. Animals were stratified by calving date, parity and BCS, and randomly assigned to either control (CON n = 18) or eCG treatments (n = 16). Read More

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January 2019
1 Read

Preimplantation factor modulates acute inflammatory responses of equine endometrium.

Vet Med Sci 2018 11 1;4(4):351-356. Epub 2018 Oct 1.

Society for the Investigation of Early Pregnancy, Cherry Hill, New Jersey, USA.

Persistent mating-induced endometritis (PMIE) is a significant cause of mare infertility hence its treatment would advance the management of susceptible mares. Preimplantation factor (PIF) is secreted by viable embryos, including human, mouse and cattle, and is essential for maternal immune-tolerance without immune-suppression by modulating inflammation. This preliminary study aimed to test whether PIF exerts inflammatory-modulating properties upon equine endometrium challenged with Escherichia coli-derived lipopolysaccharide (LPS) using endometrial explant culture. Read More

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November 2018
1 Read

Improved detection of biomarkers in cervico-vaginal mucus (CVM) from postpartum cattle.

BMC Vet Res 2018 Sep 29;14(1):297. Epub 2018 Sep 29.

Comparative Immunology Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland.

Background: In the postpartum cow, early diagnosis of uterine disease is currently problematic due to the lack of reliable, non-invasive diagnostic methods. Cervico-vaginal mucus (CVM) is an easy to collect potentially informative source of biomarkers for the diagnosis and prognosis of uterine disease in cows. Here, we report an improved method for processing CVM from postpartum dairy cows for the measurement of immune biomarkers. Read More

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September 2018
7 Reads

Risk factors of premature rupture of membranes in public hospitals at Mekele city, Tigray, a case control study.

BMC Pregnancy Childbirth 2018 Sep 29;18(1):386. Epub 2018 Sep 29.

Adigrat University College of Health Sciences, Adigart, Tigray, Ethiopia.

Background: The incidence of premature rupture of membranes ranges from about 5% to 10% of all deliveries. A woman with premature rupture of membranes is at risk of intra-amniotic infection, postpartum infection, endometritis, and death. A neonate born from premature rupture of membranes mother is at high risk of respiratory distress syndrome, sepsis, intraventricular hemorrhage and death. Read More

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September 2018
11 Reads

Cytological and bacteriological sampling from filters used for embryo recovery to evaluate the uterine status of donor mares.

Acta Vet Hung 2018 Sep;66(3):462-473

3 Centro Militar de Cría Caballar de Ecija, Cría Caballar de las F.A.S. , Ecija (Sevilla) , Spain.

While testing for uterine bacterial infection is usually performed prior to artificial insemination (AI), samples taken during or after embryo flushing are generally not assessed either in subfertile and old mares or in fertile mares, even though knowledge of the status of the uterine environment in which the embryo is to develop would help to predict the outcome of embryo transfer programmes. The presence of bacteria and inflammatory cells in the liquid retained in the filter after uterine flushing in donors was determined at the moment of embryo recovery. Primarily, a group of mares (n = 8) displaying evident clinical signs of endometritis was selected to evaluate the cytological and bacteriological findings in filters after uterine flushing and in uterine cotton swabs. Read More

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September 2018
7 Reads

Effectiveness of bipolar impedance controlled radiofrequency (NovaSure) endometrial ablation for the treatment of menorrhagia in Hong Kong Chinese women.

Gynecol Minim Invasive Ther 2017 Oct-Dec;6(4):186-190. Epub 2017 Jul 31.

Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong.

Objective: Bipolar impedance controlled radiofrequency endometrial ablation is a valuable treatment options for menorrhagia. We examined the short term outcomes of Hong Kong Chinese women undergone this procedure.

Material: All patients who underwent this procedure at Queen Elizabeth Hospital, Hong Kong during January 2013 to August 2016. Read More

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July 2017
1 Read

Complications related to induced abortion: a combined retrospective and longitudinal follow-up study.

BMC Womens Health 2018 Sep 25;18(1):158. Epub 2018 Sep 25.

Department of Obstetrics and Gynecology, Skaraborg Hospital Skövde, Skövde, Sweden.

Background: Induced abortion is one of the most common gynecological procedures in Sweden, but there is still little knowledge about the adverse effects. The aims of this study are to provide an overview of complications of medical and surgical abortions and to evaluate the impact of bacterial screening to prevent postabortal infections.

Methods: All women who underwent induced abortion at Skaraborg Hospital between 2008 and 2015 are included in the study. Read More

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September 2018
5 Reads

The influence of experimentally induced endometritis on the PPAR expression profile in the bovine endometrium.

Theriogenology 2018 Dec 15;122:74-83. Epub 2018 Sep 15.

Department of Biodiversity Protection, IARFR PAS, Tuwima Str. 10, 10-747, Olsztyn, Poland. Electronic address:

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear receptor superfamily. The PPARs activity can be modified e.g. Read More

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December 2018

Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology.

Bioengineering (Basel) 2018 Sep 18;5(3). Epub 2018 Sep 18.

Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepción, Chillán 3780000, Chile.

The endometrium is an accessible source of mesenchymal stem cells. Most investigations of endometrial mesenchymal stem cells (eMSCs) have been conducted in humans. In animals, particularly in livestock, eMSC research is scarce. Read More

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September 2018
3 Reads

Associations of subclinical hypocalcemia with fertility in a herd of grazing dairy cows.

J Dairy Sci 2018 Nov 13;101(11):10469-10477. Epub 2018 Sep 13.

Cátedra de Fisiología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata (FCV-UNLP), B1900AVW, La Plata, Argentina. Electronic address:

The main objective was to assess the associations of subclinical hypocalcemia (SCH), diagnosed at parturition (SCH-0) and 7 d in milk (SCH-7), with fertility in a herd of grazing dairy cows. Additional objectives were to characterize Ca concentration on 0 and 7 d in milk (DIM), assessing the risk factors for SCH-0 and SCH-7 and also the relationship with health status (metritis, endometritis, subclinical ketosis, and culling). A prospective observational study was carried out in a dairy farm in Argentina. Read More

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November 2018
3 Reads

Antimicrobial resistance, virulence gene profiles and molecular typing of Staphylococcus aureus isolates from dairy cows in Xinjiang, Northwest of China.

J Glob Antimicrob Resist 2018 Sep 10. Epub 2018 Sep 10.

State Key Lab of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, 730046, China.

Background: Staphylococcus aureus (SA) is one of the major pathogens causing dairy cow mastitis and endometritis. Recently, animal-derived SA strains have posed a serious threat to public health. However, little is known about antimicrobial resistance and virulence factors of SA strains isolated from dairy cows in Xinjiang China. Read More

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September 2018
2 Reads

Choice of Prophylactic Antibiotics and Surgical Site Infections After Cesarean Delivery.

Obstet Gynecol 2018 Oct;132(4):948-955

Obstetrics and Gynecology, MedStar Washington Hospital Center, Washington, DC; the Department of Biostatistics and Epidemiology, MedStar Health Research Institute, Hyattsville, Maryland; and Georgetown-Howard Universities Center for Clinical and Translational Science and Obstetrics and Gynecology, MedStar Georgetown University Hospital, Washington, DC.

Objective: To examine the rate of surgical site infection according to the choice of antibiotics in women undergoing cesarean delivery.

Methods: We conducted a retrospective cohort study of women undergoing cesarean delivery (labored, unlabored, and scheduled) from 2012 to 2017. Women with chorioamnionitis and those who did not receive any antibiotics were excluded. Read More

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October 2018
9 Reads

The Potential Therapeutic Role of miR-223 in Bovine Endometritis by Targeting the NLRP3 Inflammasome.

Front Immunol 2018 22;9:1916. Epub 2018 Aug 22.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

Bovine endometritis affects milk production and reproductive performance in dairy cows and causes serious economic loss. The underlying molecular mechanisms or signaling pathways of bovine endometritis remain unclear. In this study, we attempted to determine the expression mechanism of mir-223 in endometritis of dairy cows and evaluate its potential therapeutic value. Read More

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August 2018
2 Reads

Outcomes associated with trial of labor after cesarean in women with one versus two prior cesarean deliveries after a change in clinical practice guidelines in an academic hospital.

J Matern Fetal Neonatal Med 2018 Sep 5:1-121. Epub 2018 Sep 5.

a Department of Obstetrics and Gynecology , Division of Maternal Fetal Medicine , Baylor College of Medicine , Houston , Texas , USA.

Objective: In 2010, the American College of Obstetricians & Gynecologists (ACOG) published a new clinical practice guideline on trial of labor after cesarean (TOLAC) that was considered less restrictive. It allowed for offering TOLAC to women with two prior cesarean deliveries, even without a prior vaginal delivery, and for labor induction. As a result, our hospital, a public tertiary care academic center, updated our TOLAC practice guideline to reflect ACOG's new recommendations. Read More

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September 2018
6 Reads

Chronic inflammatory and degenerative endometrial lesions in subfertile Criollo Limonero cattle; a B. taurus Latin-American breed threatened with extinction; A case-control study.

Anim Reprod Sci 2018 Oct 25;197:22-32. Epub 2018 Jun 25.

Unidad de Investigación en Reproducción Animal, Facultad de Ciencias Veterinarias, Universidad del Zulia, Maracaibo, Venezuela.

Criollo Limonero is a tropical Bos taurus breed for sustainable dual purpose (milk and beef) production in the South-American tropics, which is currently threatened with extinction. The objective was to perform a clinical evaluation and histopathological assessment of uterine biopsy samples of repeat breeder (RB) Criollo Limonero cattle to determine the occurrence of pathological conditions as potential causes of subfertility. Twenty-four Criollo Limonero cattle [18 cows (5-13 years old) and 6 heifers (6-7. Read More

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October 2018
2 Reads

Transports Virulent and Transmits the Infection to Human Cells after Metronidazole Treatment: A Potential Role in Bacterial Invasion of Fetal Membranes and Amniotic Fluid.

J Pregnancy 2018 2;2018:5037181. Epub 2018 Aug 2.

Department of Biomedical Sciences, University of Sassari, Italy.

is considered an opportunistic pathogen able to colonize the lower urogenital tract; in females the infection is associated with severe pregnancy and postpartum complications, including abortion, endometritis, preterm delivery, and low birth weight. Molecular mechanisms of pathogenicity and virulence effectors remain poorly characterized. A number of studies in the last decade have demonstrated that can establish an endosymbiotic relationship with , a urogenital parasitic protozoon, also associated with adverse pregnancy outcomes. Read More

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August 2018
5 Reads