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Arch Gynecol Obstet 2022 May 21. Epub 2022 May 21.

, Wiesenbacher Str. 10, 69151, Neckargemünd, Germany.

Purpose: This article presents a novel concept of the evolution and, thus, the pathogenesis of uterine adenomyosis as well as peritoneal and peripheral endometriosis. Presently, no unifying denomination of this nosological entity exists.

Methods: An extensive search of the literature on primate evolution was performed. Read More

BJOG 2022 May 21. Epub 2022 May 21.

The John Radcliffe Hospital, Oxford University Hospitals, Oxford, United Kingdom.

BJOG 2022 May 21. Epub 2022 May 21.

Department of Gynecology and Obstetrics, University Hospital Münster, Albert-Schweitzer Campus 1, Building A1, Münster, Germany.

Objective: To assess the diagnostic performance of preoperative application of the Enzian classification (cEnzian) using surgical findings as reference standard DESIGN: A prospective international non-interventional study SETTING: 12 endometriosis centers in four European countries (Austria, Germany, Switzerland, and Czech Republic) POPULATION: 1062 women with endometriosis surgery METHODS: Extent of endometriosis was preoperatively classified using the cEnzian classification based on gynecological examination and/or transvaginal ultrasound (TVS) and/or magnetic resonance imaging (MRI). After subsequent surgery, the surgeon classified the intraoperative findings using the Enzian classification.

Main Outcome Measures: Sensitivity, specificity, PPV, NPV, LR+, LR- and accuracy were calculated. Read More

Endocrinology 2022 May 20. Epub 2022 May 20.

Program in Reproductive Biology, Department of Animal Science, University of Wyoming, Laramie, WY.

Progesterone receptor membrane component (PGRMC) proteins play important roles in tumor growth, progression and chemoresistance of which PGRMC1 is the best characterized. The ancestral member predates the evolution of metazoans, so it is perhaps not surprising that many of the purported actions of PGRMC proteins are rooted in fundamental metabolic processes such as proliferation, apoptosis, and DNA damage responses. Despite mediating some of the actions of progesterone (P4) and being fundamentally required for female fertility, PGRMC1 and PGRMC2 are broadly expressed in most tissues. Read More

J Minim Invasive Gynecol 2022 May 17. Epub 2022 May 17.

IFEMEndo Endometriosis Centre, Clinique Tivoli-Ducos, Bordeaux, 33000, France. Electronic address:

Study Objective: To describe our experience with the use of Natural Orifice Specimen Extraction (NOSE) technique for segmental bowel resection in patients with colorectal endometriosis.

Design: Retrospective, observational study.

Setting: Single tertiary referral centre PATIENTS: 50 consecutive patients undergoing NOSE colectomy for colorectal endometriosis in our centre, between March 2021 and November 2021. Read More

Front Immunol 2022 3;13:845944. Epub 2022 May 3.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Objective: The relationship between endometriosis and the ensuing risk of Sjögren's syndrome has remained unclear. This study aims to present epidemiological evidence for this connection.

Methods: This is a retrospective cohort study of endometriosis patients (ICD-9-CM 617. Read More

Front Mol Biosci 2022 3;9:854991. Epub 2022 May 3.

Hospital Israelita Albert Einstein, São Paulo, Brazil.

Endometriosis is a highly prevalent gynecological disease characterized by lesions in different sites. Regulation of specific estrogen pathways may favor the formation of distinct microenvironments and the progression of endometriosis. However, no study has simultaneously evaluated the gene and protein regulation of the main estrogen-synthesizing enzymes in endometriosis. Read More

Arch Med Sci 2022 21;18(3):682-689. Epub 2021 Mar 21.

Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.

Introduction: Chemokines play a crucial role in tumor growth and progression according to proangiogenic and immunosuppressive action. The aim of this study was to investigate the serum levels of selected chemokines in patients with ovarian cancer or benign ovarian tumors to assess their role in tumorigenesis and their potential use in preoperative diagnosis of an adnexal mass.

Material And Methods: The study group consisted of 59 women with ovarian cancer: 17 epithelial ovarian cancer (EOC) patients and 42 women with benign ovarian tumors. Read More

Med (N Y) 2021 May;2(5):481-485

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut 06520, USA. Electronic address:

Endometriosis has long been viewed as a pelvic disease. New evidence suggests that endometriosis is a systemic disease with multisystem involvement. A more comprehensive understanding of endometriosis will speed recognition and clarify diagnosis. Read More

Ann Surg Oncol 2022 May 19. Epub 2022 May 19.

Department of Gynaecologic Surgery, Gustave-Roussy, Villejuif, France.

Background: Endometrioid borderline ovarian tumor (EBOT) is a rare subtype of borderline ovarian malignancies. This study was designed to determine the prognosis of a series of EBOT.

Methods: This is a retrospective review of patients with EBOT treated in or referred to our institutions and a centralized, histological review by a reference pathologist. Read More

J Obstet Gynaecol Can 2021 Jun 29. Epub 2021 Jun 29.

Department of Obstetrics and Gynecology, University of California, Riverside, School of Medicine, 900 University Avenue, Riverside, CA, USA, 92521.

J Gynecol Obstet Hum Reprod 2022 May 15:102408. Epub 2022 May 15.

Department of Obstetrics and Gynecology, Rennes University Hospital; Rennes, University 1, Rennes, France; INSERM, LTSI - UMR 1099. Electronic address:

Introduction: Endometriosis is a chronic inflammatory disease with a negative impact on fertility. The Enzian classification provides a precise description of deep pelvic endometriotic lesions, especially in the retroperitoneal area, from preoperative pelvic MRI scans. However, it is not known if it is correlated with postoperative fertility. Read More

Am J Med Sci 2022 May 16. Epub 2022 May 16.

Pulmonology Divison of Internal Medicine Department of Botucatu Medical School, UNESP, Botucatu, São Paulo, Brazil.

Braz J Med Biol Res 2022 27;55:e11948. Epub 2022 Apr 27.

Department of Biology, Faculty of Basic Sciences, Razi University, Kermanshah, Iran.

Endometriosis (EMS) is one of the most prevalent causes for female infertility. Herein, we investigated the effect of the repaglinide (RG), L-carnitine (LC), and bone marrow mesenchymal stem cell-conditioned medium (BMSC-CM) supplementation during in vitro maturation (IVM) on the quality, maturation, and fertilization rates, as well as embryonic quality and development of oocytes derived from normal and EMS mouse model. Immature oocytes were collected from two groups of normal and EMS-induced female NMRI mice at 6-8 weeks of age. Read More

Gynecol Endocrinol 2022 May 19:1-5. Epub 2022 May 19.

Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.

Objective: Many genes and miRNAs have been shown to be associated with the pathogenesis of endometriosis. (p63) is implicated in lineage specification, proliferative potential, differentiation, cell death and survival. The proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase implicated in cell differentiation, cell division, and cell adhesion. Read More

Eur J Obstet Gynecol Reprod Biol X 2022 Aug 4;15:100152. Epub 2022 May 4.

Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Endometrios affecting 6-10% of women of reproductive ages around the globe. Important pathways, including the MAPK and PI3K / Akt pathways, have been identified in the disease. The NF1 and RASA1 genes inactivate Ras by their own GTPase activity and controlled the high activity of these pathways. Read More

Urol Case Rep 2022 Jul 7;43:102110. Epub 2022 May 7.

Shuakat Khanum Memorial Cancer Hospital and Research Center Lahore, Pakistan.

Endometriosis is a common gynecological disorder in which endometrial tissue is located outside the uterine cavity. Urinary tract involvement by endometriosis is uncommon. Renal endometriosis is a rare disorder and is not evident on imaging. Read More

BMC Womens Health 2022 May 18;22(1):184. Epub 2022 May 18.

Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China.

Objective: To determine the potential diagnostic markers and extent of immune cell infiltration in endometriosis (EMS).

Methods: Two published profiles (GSE7305 and GSE25628 datasets) were downloaded, and the candidate biomarkers were identified by support vector machine recursive feature elimination analysis and a Lasso regression model. The diagnostic value and expression levels of biomarkers in EMS were verified by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blotting, then further validated in the GSE5108 dataset. Read More

Phytother Res 2022 May 18. Epub 2022 May 18.

Department of Biomedicine - Experimental Biology Unit, Faculty of Medicine of the University of Porto, Porto, Portugal.

Endometriosis, a gynecological disease that affects reproductive age women is difficultly controlled in the long term by currently available treatments, prompting patients to adopt self-controlled interventions including dietary changes. The aim of this review is to provide evidence of how curcumin, quercetin, and resveratrol can act as natural interventions to control endometriosis. The review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Read More

Int J Med Sci 2022 21;19(4):651-658. Epub 2022 Mar 21.

Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.

The study aims to evaluate long-term ovarian reserve change by serum anti-Mullerian hormone (AMH) level and determine the factors that affect the changes after laparoscopic endometrioma cystectomy. In a prospective longitudinal study, 104 patients with unilateral (n=77) and bilateral (n=27) endometrioma underwent laparoscopic endometrioma cystectomy. AMH levels were measured preoperatively and at 1, 3, 6, and 12 months postoperatively. Read More

Int J Med Sci 2022 11;19(4):769-778. Epub 2022 Apr 11.

Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People's Republic of China.

Interleukin-17 (IL-17) is known as a Th17-cell-derived proinflammatory cytokine, which plays a pivotal role in several inflammatory and autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis, and psoriasis. Emerging evidence has shown that IL-17 is linked to endometriosis, although the etiology of endometriosis is still unknown. The IL-17 expression is up-regulated in serum, peritoneal fluid (PF) and endometriotic lesions from patients with endometriosis but the related regulation mechanisms are complex and obscure. Read More

Biomed Res Int 2022 7;2022:8620077. Epub 2022 May 7.

Department of Surgical, Oncologic and Gastroenterologic Sciences, First Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padova, Italy.

Background: Palmitoylethanolamide is reported to solve pain and neuroinflammation in different models of chronic and neurodegenerative diseases. Some concerns have been illustrated for cautiously interpreting the available literature on the topic. Specifically, there is a lack of evidence about palmitoylethanolamide and female chronic pelvic pain. Read More

Sci Rep 2022 May 16;12(1):8031. Epub 2022 May 16.

Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.

Endometriosis, which exhibits enigmatic pathological features such as stromal fibrosis and proliferation of ectopic epithelial cells, is known as a refractory disease. Mesenchymal stem cells modulate the fibrosis in stromal tissues through their trophic and immunomodulatory properties. To investigate the potential of stem cells in treating endometriosis, we examined the secondary morphology and molecular alterations in endometriosis-like lesions after the administration of adipose tissue-derived stem cells (ASCs) to an experimental murine model of endometriosis. Read More

Rev Bras Ginecol Obstet 2022 Mar 16;44(3):295-303. Epub 2022 May 16.

Departamento de Ginecologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Introduction:  Endometriosis is an inflammatory disease that affects women of reproductive age, causing pain and the possibility of infertility. Endometriosis was associated to low life quality and research shows the impact of endometriosis in several areas of life, justifying how these patients are more likely to develop depression, anxiety, and stress.

Objective:  The aim of the present systematic review was to explore the field of psychology in endometriosis, identifying studies that used the cognitive behavioral therapy technique as a treatment for endometriosis and chronic pelvic pain. Read More

Clinics (Sao Paulo) 2022 13;77:100032. Epub 2022 May 13.

Endometriosis Section, Divisão de Clínica Ginecológica, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil; Gynecologic Division, BP ‒ A Beneficência Portuguesa de São Paulo, São Paulo, SP, Brazil. Electronic address:

Objective: To evaluate the frequencies of iNKT cells and their subsets in patients with deep endometriosis.

Methods: A case-control study was conducted between 2013 and 2015, with 73 patients distributed into two groups: 47 women with a histological diagnosis of endometriosis and 26 controls. Peripheral blood, endometriosis lesions, and healthy peritoneal samples were collected on the day of surgery to determine the frequencies of iNKT cells and subtypes via flow cytometry analysis. Read More

Ann Diagn Pathol 2022 May 10;59:151975. Epub 2022 May 10.

Department of Pathology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Background: Focal liver lesions with spindle cell morphology are rare in the daily practice of pathology. The differential diagnosis is broad, including both tumors and tumor-like lesions. Initial radiologic assessment is sometimes inaccurate. Read More

Obstet Gynecol 2022 May 5;139(5):821-831. Epub 2022 Apr 5.

Department of Obstetrics and Gynecology, Northwestern Feinberg School of Medicine, Chicago, Illinois; the Division of Urological Surgery, Brigham and Women's Hospital, Harvard Medical School, the Harvard Radiation Oncology Program, and the Brigham and Women's Hospital/Mass General Hospital Integrated Residency Program in Obstetrics and Gynecology, Boston, Massachusetts; the Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, Tennessee; the Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, the UCSF School of Medicine, San Francisco, and the Stanford University School of Medicine, Stanford, California; the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and the Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Washington, Seattle, Washington.

Objective: To characterize gynecology clinical trials over time, compare gynecology subspecialties, and analyze factors associated with early discontinuation, results reporting, and publication.

Methods: We conducted a cross-sectional analysis of all gynecology trials registered on ClinicalTrials.gov between 2007 and 2020 and their resulting publications. Read More

Gynecol Oncol Rep 2022 Jun 6;41:100995. Epub 2022 May 6.

Mayo Clinic Department of Medical and Surgical Gynecology, Mayo Clinic, Jacksonville, FL, United States.

Abdominal wall endometriosis with subsequent transformation to clear cell carcinoma is quite rare. The pathogenesis and pattern of this transformation is not well known; hence evaluation and management guidelines are not well established. We highlight a case of clear cell adenocarcinoma arising from the anterior abdominal wall in a previous cesarean section scar treated with excision and the unique addition of Trastuzumab for adjuvant chemotherapy. Read More

Front Endocrinol (Lausanne) 2022 28;13:798434. Epub 2022 Apr 28.

Hebei Key Laboratory of Infertility and Genetics, Hebei Clinical Research Center for Birth Defects, Department of Reproductive Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: To evaluate the pregnancy outcomes of progestin-primed ovarian stimulation (PPOS) protocol for patients with endometrioma underwent fertilization/intra-cytoplasmic sperm injection embryo transfer (IVF/ICSI-ET).

Design: Observational retrospective cohort study.

Setting: University affiliated reproductive center. Read More

Front Med (Lausanne) 2022 28;9:879015. Epub 2022 Apr 28.

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università degli Studi della Campania Luigi Vanvitelli, Caserta, Italy.

Endometriosis is a gynecological disease characterized by the growth of endometrial glands and stroma outside the uterine cavity. The incidence of the disease is very high, there are currently no reliable early diagnostic tests, the therapies are only symptomatic and, consequently, the social impact of endometriosis is very important, also considering the related fertility problems. Despite this, the pathogenesis of endometriosis is still not fully defined. Read More