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Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Elizabeth Garrett Anderson UCL Institute of Women's Health, University College London Hospitals, 250 Euston Road, London, NW12PG.

Discordance between gonadal type and gender identity has often led to an assumption of infertility in patients with differences in sex development (DSD). However, there is now greater recognition of fertility being an important issue for this group of patients. Currently, gonadal tissue that may have fertility potential is not being stored for individuals with DSD and, where gonadectomy forms part of management, is often discarded. Read More

Biol Reprod 2019 Apr 20. Epub 2019 Apr 20.

Competence Centre on Health Technologies; Tartu, Estonia.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Endometriosis is a frequent and chronic illness in young women which could be defined by the existence of endometrial stroma and glands outside of the normal site of the lining of the uterus. It has painful symptoms. The advanced stage of endometriosis may lead to gynecological malignancies, such as ovarian cancer, and other complications, including infertility. Read More

Endocr Rev 2019 Apr 17. Epub 2019 Apr 17.

Departments of Obstetrics and Gynecology, Northwestern University, Chicago, IL.

Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. Read More

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):336-341. Epub 2019 Apr 11.

Department of Gynecology, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan City, Hubei Province, 430074, China.

Objective: Ovarian endometriosis seriously affects the quality of life of females, and long non-coding RNA lncRNA urothelial carcinoma-associated 1 (UCA1) plays pivotal roles in the pathogenesis of various ovarian diseases. However, the involvement of lncRNA UCA1 in ovarian endometriosis remains unknown to date. Therefore, the present study aims to study the role of UCA1 in ovarian endometriosis. Read More

Clin Obstet Gynecol 2019 Apr 15. Epub 2019 Apr 15.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York.

Infertility is estimated to affect about 10% to 15% of couples. Most cases of infertility have etiologies that can be attributed to tubal factors, ovulatory dysfunction, endometriosis, uterine factor, male factor, or diminished ovarian reserve, while the remainder often do not have a known attributable cause, that is, unexplained infertility. The current manuscript summarizes the contemporary management of unexplained infertility. Read More

J Dtsch Dermatol Ges 2019 Apr 17. Epub 2019 Apr 17.

University Hospital Heidelberg, Department of Dermatology and National Center for Tumor Diseases (NCT), Heidelberg, Germany.

Clin Proteomics 2019 6;16:14. Epub 2019 Apr 6.

1Department of Women's Cancer, Institute for Women's Health, University College London, Cruciform Building 1.1, Gower Street, London, WC1E 6BT UK.

Background: Endometriosis is a common gynaecological disorder affecting 5-10% of women of reproductive age who often experience chronic pelvic pain and infertility. Definitive diagnosis is through laparoscopy, exposing patients to potentially serious complications, and is often delayed. Non-invasive biomarkers are urgently required to accelerate diagnosis and for triaging potential patients for surgery. Read More

Fertil Steril 2019 Apr 13. Epub 2019 Apr 13.

Augusta University, Augusta, Georgia.

Objective: To evaluate the efficacy of elagolix, an oral GnRH antagonist, for the reduction of fatigue in women with moderate or severe endometriosis-associated pain.

Design: Randomized, double-blind, multicenter, placebo-controlled phase III trial.

Setting: Clinics. Read More

Rev Bras Ginecol Obstet 2019 Mar 16;41(3):170-175. Epub 2019 Apr 16.

University of Siena, Siena, Italy.

Objective:  Endometriosis is a complex disease, and pain is an important component of the syndrome. One of the most used methods to assess pain is the visual analogue scale (VAS). The aim of the present research was to study the pain experienced by patients who referred to our unit for endometriosis, using the VAS to understand the variables that could influence it. Read More

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1094-1098

Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China.

Endometriosis is a common and difficult gynecological disease. The incidence of endometriosis has been increasing year by year. Because endometriosis mostly occurs in childbearing age,it can cause persistent damage to the fertility of patients,and is an important cause of infertility. Read More

Hum Reprod 2019 Apr 16. Epub 2019 Apr 16.

EA 7285 Research Unit 'Risk and Safety in Clinical Medicine for Women and Perinatal Health', Versailles-Saint-Quentin University (UVSQ), Montigny-le-Bretonneux, France.

Study Question: Is the Sexual Activity Questionnaire (SAQ) a valid tool for patients treated for symptomatic endometriosis?

Summary Answer: For women having surgical treatment for endometriosis, we determined that the SAQ is a valid and responsive tool.

What Is Known Already: Endometriosis adversely affects sexual quality of life. Suitable validated sexual quality of life instruments for endometriosis are lacking both in clinical practice and for research. Read More

Hum Reprod 2019 Apr 16. Epub 2019 Apr 16.

Department of Gynecology, Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei, PR China.

Study Question: Is the methylation status of the glutathione S-transferase M1 (GSTM1) promoter region altered in patients with ovarian endometriosis, and does this affect the expression of GSTM1 in their endometrial tissues?

Summary Answer: The promoter region of GSTM1 was significantly hypomethylated in the ectopic and eutopic endometrium of patients with ovarian endometriosis and this was associated with higher expression of GSTM1 mRNA.

What Is Known Already: GSTM1, a member of the glutathione S-transferase family, is primarily known as a detoxification enzyme, but it has also been shown to negatively regulate apoptosis-related signalling cascades through protein-protein interactions with apoptosis signal-regulating kinase-1.

Study Design, Size, Duration: This is a case-control study between September 2013 and December 2016, involving 65 patients with ovarian endometriosis and 53 women without endometriosis. Read More

Exp Ther Med 2019 May 6;17(5):3267-3281. Epub 2019 Mar 6.

Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, Heraklion 71003, Greece.

Endometriosis is a pathological condition which has been extensively studied, since its pathophysiology stems from a broad spectrum of environmental influences and genetic factors. Familial studies aim at defining inheritance trends, while linkage analysis studies focus on the identification of genetic sites related to endometriosis susceptibility. Genetic association studies take into account candidate genes and single nucleotide polymorphisms, and hence target at unraveling the association between disease severity and genetic variation. Read More

J Minim Invasive Gynecol 2019 Apr 12. Epub 2019 Apr 12.

Department of Gynecological Surgery, Mayo Clinic Hospital, Arizona, USA.

Cochrane Database Syst Rev 2019 Apr 15;4:CD011422. Epub 2019 Apr 15.

Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Group, 1st Floor Education Centre, Royal United Hospital, Combe Park, Bath, UK, BA1 3NG.

Background: This is an updated merged review of two originally separate Cochrane reviews: one on robot-assisted surgery (RAS) for benign gynaecological disease, the other on RAS for gynaecological cancer. RAS is a relatively new innovation in laparoscopic surgery that enables the surgeon to conduct the operation from a computer console, situated away from the surgical table. RAS is already widely used in the United States for hysterectomy and has been shown to be feasible for other gynaecological procedures. Read More

Reprod Biol Endocrinol 2019 Apr 15;17(1):36. Epub 2019 Apr 15.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, 310 Cedar Street, New Haven, CT, 06520, USA.

Background: Endometriosis is an estrogen dependent, inflammatory disorder occurring in 5-10% of reproductive-aged women. Women with endometriosis have a lower body mass index (BMI) and decreased body fat compared to those without the disease, yet few studies have focused on the metabolic abnormalities in adipose tissue in women with endometriosis. Previously, we identified microRNAs that are differentially expressed in endometriosis and altered in the serum of women with the disease. Read More

Gynecol Endocrinol 2019 Apr 13:1-5. Epub 2019 Apr 13.

b Department of Respiratory Medicine , The 940th Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army (Former Lanzhou General Hospital of Lanzhou Military Region) , Lanzhou , China.

Objective: To investigate the MRI manifestations of congenital vaginal atresia, analyze its imaging features, and improve the understanding of the disease.

Methods: MRI findings and clinical data of 12 patients with congenital vaginal atresia confirmed by hysteroscopy and laparoscopic surgery were retrospectively analyzed. Vaginal atresia was classified according to vaginal dysplasia in AFS female genital malformation classification system. Read More

Reprod Biomed Online 2019 Jan 31. Epub 2019 Jan 31.

Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan.

Research Question: Is there any relationship between numbers of FOXP3 regulatory T-cells (Treg) and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cysts?

Design: Retrospective and prospective case-controlled cohort study. Peritoneal lesions were collected from 27 women with ovarian endometrioma and 25 women with dermoid cysts. Peritoneal fluid was collected from 36 women with ovarian endometrioma and 42 women with dermoid cysts. Read More

Reprod Biol Endocrinol 2019 Apr 13;17(1):38. Epub 2019 Apr 13.

Division of Gynecology, University Hospital Zurich, Frauenklinikstrasse 10, CH-8091, Zürich, Switzerland.

Background: Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a potent MMP-inhibitor in subantimicrobial doses.

Methods: Gelatin zymography and activity assays were used to detect latent and active MMP-2 and -9 in cell culture supernatants of immortalized epithelial (12Z) and two isolates of primary endometriotic stromal cells treated with doxycycline. Read More

J Minim Invasive Gynecol 2019 Apr 10. Epub 2019 Apr 10.

Department of Thoracic Surgery, Jean Perrin Comprehensive Cancer Center, Clermont-Ferrand, France.

Study Objective: Laparoscopic resection of diaphragmatic endometriosis has the advantages of a minimally invasive approach. The standardization and description of the technique are the main objectives of this video. We described the procedure in 10 steps to make it easier and safer. Read More

Contraception 2019 Apr 10. Epub 2019 Apr 10.

Sexual Health and Reproductive Equity Program, School of Social Welfare, University of California, Berkeley, 110 Haviland Hall MC 7400, Berkeley, CA 94720-7400, USA.

Objective: To explore perspectives on family planning among young people who perceive they are infertile or will have difficulty carrying a pregnancy to term owing to medical conditions or procedures.

Methods: This exploratory analysis examined pregnancy plans and contraceptive behavior among 12 young adults with a diagnosed medical condition or who had undergone a medical procedure associated with impaired fertility, and who had discussed fertility with a healthcare provider. We utilized data from a larger study investigating prospective pregnancy intentions and plans among 50 young (ages 18-24) women and their male partners (n=100). Read More

Arch Gynecol Obstet 2019 Apr 12. Epub 2019 Apr 12.

Department of Gynecology, University Hospital Zurich, Zurich, Switzerland.

Purpose: Comparison of preoperative magnetic resonance imaging (MRI) with intraoperative findings in patients with deep infiltrating endometriosis (DIE) by means of the ENZIAN score.

Methods: This retrospective two-center study includes 63 patients with deep infiltrating endometriosis, who underwent surgery between 2012 and 2016 at both the University Hospital of Zurich and the Cantonal Hospital of Schaffhausen. Inclusion criteria were a preoperative pelvic MRI and intraoperative or bioptic confirmation of DIE. Read More

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

I Meinhold-Heerlein, Institute of Gynecology and Obstetrics, Justus Liebig Universitat Giessen, Giessen, Germany.

The diagnosis of endometriosis is based upon the histological identification of endometrial tissue at ectopic sites which are commonly located on the pelvic organs, the peritoneum and ovary. In rare cases, ectopic lesions can be found in other organs, such as kidney, bladder, lung or brain. Diagnosis is achieved by laparoscopic intervention followed by histological confirmation of endometriotic tissue. Read More

Ultrasound Obstet Gynecol 2019 Apr 11. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Clínica Universidad de Navarra, School of Medicine, University of Navarra, Pamplona, Spain.

Objectives: Due to the reported high sensitivity and specificity of ultrasound in the detection rate of rectosigmoid (RS) endometriosis when performed by an ultrasonographic (US) expert, this test should be considered a gold standard comparable to laparoscopy. No information is available regarding US soft markers in this disease. The aim of this study was to evaluate the use of US soft markers as "first level" examination in the suspicion of RS endometriosis. Read More

J Pediatr Adolesc Gynecol 2019 Apr 8. Epub 2019 Apr 8.

Department of Obstetrics, Gynecology, and Women's Health, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States.

Background: Complications associated with imperforate hymen include cyclical abdominal pain, acute urinary retention, endometriosis, and even iatrogenic infections.

Case: A 14 year old female was diagnosed with an imperforate hymen, hematocolpos, and right hematosalpinx. A hymenotomy was performed, followed by a hymenectomy three days later. Read More

Int J Gynaecol Obstet 2019 Apr 11. Epub 2019 Apr 11.

Department of Gynecology, Institut Clínic of Gynecology, Obstetrics and Neonatology, Hospital Clínic of Barcelona, Barcelona, Spain.

Objective: To estimate the prevalence of fibromyalgia among women with endometriosis and analyze the effect of fibromyalgia on health-related quality of life (HRQoL).

Methods: An observational case-control study conducted at a tertiary hospital in Barcelona between April 2015 and March 2017 among women with deep infiltrating endometriosis (DIE; n=80), women with superficial endometriosis or ovarian endometrioma (non-DIE; n=76), and control women without endometriosis (n=73). Fibromyalgia was assessed via the London Fibromyalgia Epidemiological Study Screening Questionnaire (LFESSQ). Read More

Curr Opin Obstet Gynecol 2019 Apr 9. Epub 2019 Apr 9.

Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Purpose Of Review: Use of patient-reported outcome measures in clinical practice and research is becoming more prevalent and reflects initiatives to center the patient in healthcare delivery and outcomes assessment. The purpose of this review is to provide a summary description of selected, validated tools used to assess outcomes related to several benign gynecologic conditions: abnormal uterine bleeding, fibroids and endometriosis.

Recent Findings: Given the availability of several validated instruments to assess patient outcomes in benign gynecology, there is still significant heterogeneity in tools used in trials. Read More

Acta Obstet Gynecol Scand 2019 Apr 10. Epub 2019 Apr 10.

Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark.

Introduction: Deep infiltrating endometriosis is a common cause of pelvic pain. However, some patients have limited problems that may be controlled by medical treatment, thus avoiding potentially severe complications to major surgery. This approach requires detailed knowledge on the quality of life and clinical symptoms over time. Read More

JBRA Assist Reprod 2019 Apr 10. Epub 2019 Apr 10.

Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, Iran.

Objective: The relation between excessive prolactin and endometriosis-related infertility is debatable. Anovulation or defective luteal phase occurs frequently due to hyperprolactinemia in subfertile women. In this investigation, we evaluated the association between serum prolactin levels and the severity of endometriosis. Read More

Hum Reprod Open 2019 3;2019(2):hoz007. Epub 2019 Apr 3.

EA 7285 Research Unit 'Risk and Safety in Clinical Medicine for Women and Perinatal Health', Versailles-Saint-Quentin University (UVSQ), Montigny-le-Bretonneux, France.

Study Question: Could we construct and validate a preoperative score to predict rectosigmoid involvement in endometriosis (RE)?

Summary Answer: We developed a simple preoperative score (ENDORECT) to predict RE.

What Is Known Already: Accurate preoperative classification is important to optimize the surgical approach for patients with endometriosis but there is currently no reliable first-line examination to determine RE.

Study Design Size Duration: This was a single-centre observational study including all women ( = 119) who underwent complete surgery for endometriosis between January 2011 and June 2016 in the Gynaecological Department of the University Hospital of Poissy Saint-Germain en Laye. Read More

J Minim Invasive Gynecol 2019 Apr 6. Epub 2019 Apr 6.

Department of Obstetrics and Gynecology, University of Tokyo.

Study Objective: To identify the clinical presentation, diagnostic evaluation, operative or medical management, and postoperative recurrence of umbilical endometriosis.

Design: A retrospective national survey.

Setting: Obstetrics and gynecology and plastic surgery departments at a teaching hospital in Japan. Read More

J Minim Invasive Gynecol 2019 Apr 6. Epub 2019 Apr 6.

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China. Electronic address:

Objective: To compare the diagnostic accuracy of different hormonal biomarkers and to find the most effective hormonal biomarker for the diagnosis of endometriosis.

Data Sources: We conducted a systematic search using PubMed, EMBASE, Cochrane Library, and China Biomedical Literature to identify relevant studies from the first day of databases to August 2018.

Methods Of Study Selection: Two independent reviewers screened for study eligibility and extracted data. Read More

PLoS One 2019 9;14(4):e0214842. Epub 2019 Apr 9.

Santa Casa de Misericórdia de Sao Paulo, Sao Paulo, Brazil.

Introduction: Intestinal endometriosis is considered the most severe form of deep endometriosis, the rectosigmoid being involved in about 90% of cases of bowel infiltration. Transvaginal sonography (TVS) and magnetic resonance imaging (MRI) have been used for noninvasive diagnosis and preoperative mapping of rectosigmoid endometriosis (RE), but no consensus has been reached so far regarding which method is the most accurate in this setting.

Objective: We aimed at performing a systematic review and meta-analysis to compare the accuracy of TVS versus MRI in the diagnosis of RE in a same population. Read More

Indian J Med Res 2018 Dec;148(Supplement):S100-S106

Department of Molecular & Human Genetics, Banaras Hindu University, Varanasi, India.

S100 proteins are calcium (Ca)-binding proteins and these have an important function in progression, manifestation and therapeutic aspects of various inflammatory, metabolic and neurodegenerative disorders. Based on their involvement in intracellular or extracellular regulatory effects, S100 proteins are classified into three subgroups: one subgroup is specialized in exerting only intracellular effects, other performs both intracellular and extracellular functions and the third subgroup members only display extracellular regulatory effects. S100 proteins are expressed particularly in vertebrates and have cell-specific expression. Read More

Wien Med Wochenschr 2019 Apr 8. Epub 2019 Apr 8.

Department of Pathology H4.312, University Medical Center Utrecht, Utrecht, The Netherlands.

Descriptions of endometriosis in 18th century monographs and manuscripts are rare and the recorded macroscopic features of endometriosis seldom support this attribution to the described cases. Recently, we became aware of an anonymous German autopsy report from the 18th century. After transcription, the manuscript was assessed by pathologists with historical expertise. Read More

Sex Med 2019 Apr 3. Epub 2019 Apr 3.

BC Women's Center for Pelvic Pain and Endometriosis, Vancouver, British Columbia, Canada; Women's Health Research Institute, Vancouver, British Columbia, Canada; Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada; BC Centre for Vulvar Health, Vancouver, British Columbia, Canada. Electronic address:

Introduction: Pelvic pain and vulvar pain are common conditions in women. In this study, we sought to characterize the clinical picture of patients with concurrent pelvic pain and provoked vestibulodynia (PVD).

Aim: To analyze the association between sexual/clinical characteristics and a diagnosis of PVD among women with pelvic pain. Read More

Arch Gynecol Obstet 2019 Apr 5. Epub 2019 Apr 5.

Centre for Endometriosis and Minimally Invasive Gynaecology (CEMIG), Ashford & St. Peter's Hospital NHS Foundation Trust, Chertsey, UK.

Purpose: To examine peri-operative complications in patients undergoing laparoscopic excision of deeply infiltrating endometriosis (DIE).

Methods: This was a prospective study of a case series of women having laparoscopic excision of deeply infiltrating endometriosis from September 2013 through August 2016 in a tertiary referral center for endometriosis and minimally invasive gynaecological surgery in Iran. Data collected included demographics, baseline characteristics, intraoperative and postoperative data up to 1 month following surgery. Read More

Cancer Epidemiol Biomarkers Prev 2019 Apr 4. Epub 2019 Apr 4.

Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School.

Background: CA125 is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Read More

Medicine (Baltimore) 2019 Apr;98(14):e14776

Department of Obstetrics and Gynaecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan.

This study aims to examine the expression of p53, p16, and murine double minute 2 (MDM2) protein in normal endometrium and endometriosis, in order to discuss the role of p53, p16, and MDM2 protein and apoptosis in the pathogenesis and development of endometriosis, and provide a theoretical basis for clinical diagnosis and treatment.The immunohistochemical streptavidin-biotin peroxidase method was used to detect the expression of p53, p16, and MDM2 in tissue samples obtained from 30 women with pathologically confirmed ovarian endometriosis and 29 women with pathologically confirmed normal endometrium. The relationship between p53, p16, and MDM2 expression and apoptosis was analyzed. Read More

Am J Dermatopathol 2019 Apr 15. Epub 2019 Apr 15.

Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA.

Cutaneous endometriosis is an uncommon dermatologic disorder predominantly seen in young women. Most commonly, it presents within a region of a previous surgical scar, often in relation to a gynecologic procedure on the abdomen or in close proximity to the umbilicus. The typical clinical presentation is that of papules or nodules with monthly cyclical pain and size variation. Read More

BMC Womens Health 2019 Apr 3;19(1):50. Epub 2019 Apr 3.

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

BMC Cancer 2019 Apr 3;19(1):308. Epub 2019 Apr 3.

Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

Background: Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involvement in ovarian tumorigenesis. Herein, we focused on the functional roles of Nodal in ovarian endometriosis-carcinoma lesions. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Mar 19;236:177-182. Epub 2019 Mar 19.

Center of Gynecologic Oncology, Peking University People's Hospital, Beijing, China. Electronic address:

Objective(s): CHL1 (close homologue of L1 or cell adhesion molecule L1 like), also referred as CALL, is a member of the L1 gene family of neural cell adhesion molecules and belongs to immunoglobulin superfamily. This study aims to investigate the potential correlation of the CHL1 gene and the long non-coding RNAs (lncRNAs), i.e. Read More

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1181-1193

d Department of Biochemistry , Hamadan University of Medical Sciences , Hamadan , Iran.

The objective of this study was to assess the antibacterial activity of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus 544. Rifampicin-loaded solid lipid nanoparticles were prepared by a modified microemulsion/sonication method and characterized. The results showed the average size about 319. Read More

Cell Mol Biol (Noisy-le-grand) 2019 Mar 31;65(3):94-100. Epub 2019 Mar 31.

Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital School of Medicine Zhejiang University, Qingchun Road 3rd, Zhejiang Hangzhou 310016, China.

The purpose of this study was to investigate the difference of Twist gene promoter methylation among ovarian ectopic endometrium, eutopic endometrium and non-endometriosis (EMs) endometrium . 15 patients with reproductive age hospitalized at Department of obstetrics and gynecology affiliated to Medicine School of Zhejiang University from January 2013 to June 2016 were selected. Among them, 5 patients underwent laparoscopic surgery due to ovarian type EMs, and were selected after histologic confirmation. Read More

Abdom Radiol (NY) 2019 Apr 2. Epub 2019 Apr 2.

Department of Diagnostic Radiology, Abdominal Division, Mayo Clinic Hospital, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Purpose: Transformation of benign endometriosis to endometriosis-associated ovarian carcinoma (EAOC) is rare; however, women with endometriosis are four times more likely to develop EAOC which can present 20 years earlier than de novo ovarian cancer. Presenting symptoms are often vague and the radiologist's role in recognizing EAOC is critical for early detection and treatment. Histopathologic evaluation remains the mainstay for definitive diagnosis. Read More

Reprod Biomed Online 2019 Jan 8. Epub 2019 Jan 8.

Clinical Cytology and STD Laboratory, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, PR, Brazil. Electronic address:

Research Question: Is there an association between the presence of sexually transmitted pathogens in the lower (LGT) and upper (UGT) female genital tract with endometriosis and infertility?

Design: Case-control study with 60 women submitted to gynaecological laparoscopic surgery. Samples from the UGT and LGT were collected and analysed by single polymerase chain reaction (PCR) for human papillomavirus (HPV) and by multiplex PCR for other sexually transmitted infections (STI). Patients were initially divided into two clinical groups: infertile patients (n = 25) with conjugal infertility and fertile control patients (n = 35). Read More

Pharmazie 2019 Apr;74(4):243-249

This study aimed to elucidate the roles and regulatory mechanism of miR-2861 in the development of endometriosis. The expression of miR-2861 in endometriotic tissues and eutopic endometrial tissues was determined. Ectopic endometrial cells were transfected with miR-2861 mimic, miR-2861 inhibitor and their corresponding controls. Read More