25,896 results match your criteria Endometriosis


Uterine contractility changes in a perfused swine uterus model induced by local anesthetics procaine, lidocaine, and ropivacaine.

PLoS One 2018 6;13(12):e0206053. Epub 2018 Dec 6.

Department of Gynecological Endocrinology and Fertility Disorders, University of Heidelberg, Heidelberg, Germany.

Background: Local anesthetics (LAs) are increasingly used as therapeutics due to their multiple molecular effects. They may be potential agents also in gynecology and reproductive medicine. The objective of this study was to investigate the contractility response of the perfused swine uterus to different concentrations of the LAs procaine, lidocaine, and ropivacaine. Read More

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December 2018

My Womban's Life: Understanding Human Endometrial Function.

Authors:
Lois Salamonsen

Reproduction 2018 Dec 1. Epub 2018 Dec 1.

L Salamonsen, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Australia.

The focus of my life in science, has been to improve reproductive health for women, with an emphasis on the endometrium, the most dynamic tissue in the human body: its remarkable cyclical remodelling is essential for establishment of pregnancy. The most notable events in a woman's endometrial cycle are menstruation and endometrial repair, regeneration of the endometrium during the proliferative phase, attainment of receptivity by the mid-secretory phase of the cycle and the embryo-maternal interactions that initiate peri-implantation events within the microenvironment of the uterine cavity. I have contributed to understanding the molecular and cellular changes underpinning these events, and how disturbance of them leads to menstrual disorders, infertility and endometrial diseases including abnormal uterine bleeding, endometriosis and endometrial cancer. Read More

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December 2018

Robotic surgery in the management of complex pelvic endometriosis.

Int Braz J Urol 2018 Oct 20;44. Epub 2018 Oct 20.

Department of Urology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Introduction: Endometriosis consists in the proliferation of endometrial tissue outside of the uterine cavity, predominantly in the ovaries but also in the urinary bladder or bowel. About 10% of fertile women are affected and the main symptoms are pain, menstrual disorders and infertility. Surgery is the treatment option for those symptomatic patients in which medical treatment had no success. Read More

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October 2018
1 Read

Villainous role of estrogen in macrophage-nerve interaction in endometriosis.

Reprod Biol Endocrinol 2018 Dec 5;16(1):122. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, First Affiliated Hospital, Sun Yat-sen University, No. 58, the 2nd Zhongshan Road, Yuexiu District, Guangzhou, Guangdong Province, China.

Endometriosis is a complex and heterogeneous disorder with unknown etiology. Dysregulation of macrophages and innervation are important factors influencing the pathogenesis of endometriosis-associated pain. It is known to be an estrogen-dependent disease, estrogen can promote secretion of chemokines from peripheral nerves, enhancing the recruitment and polarization of macrophages in endometriotic tissue. Read More

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December 2018
1 Read

Type of pelvic disease as a risk factor for surgical site infection in women undergoing hysterectomy.

J Minim Invasive Gynecol 2018 Nov 30. Epub 2018 Nov 30.

The Ottawa Hospital Research Institute, 725 Parkdale Avenue, Ottawa ON, K1Y 4E9.

Study Objective: To quantify the relationship between type of benign pelvic disease and risk of surgical site infection (SSI) after hysterectomy DESIGN: Retrospective Cohort (Classification II-2) SETTING: Hospitals participating in the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) PATIENT(S): Women who underwent hysterectomy from 2006-2015 and recorded in NSQIP database INTERVENTION: None MEASUREMENTS AND MAIN RESULTS: SSI risk was compared for type of benign pelvic diseases, patient characteristics (age, race and selected comorbidities) and process of care variables (admission status, type of hysterectomy, and operative time). Among a total of 125,337 women who underwent hysterectomy, 2.48% developed SSI. Read More

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November 2018

Risk factors related to the recurrence of endometrioma in patients with long-term postoperative medical therapy.

Ginekol Pol 2018 ;89(11):611-617

Department of Obstetrics and Gynecology, Pusan National University School of Medicine Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Objectives: The purpose of this study was to identify clinical risk factors for the recurrence of ovarian endometrioma after ovarian cystectomy in Korean women with long-term postoperative medical therapy.

Material And Methods: A total of 134 patients who were surgically treated for endometriotic cysts at Pusan National University Hospital were included in this retrospective study. All patients received long-term postoperative medical treatment for at least 12 months after the first-line conservative surgery. Read More

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January 2018

Long non-coding RNA AFAP1-AS1 promoting epithelial-mesenchymal transition of endometriosis is correlated with transcription factor ZEB1.

Am J Reprod Immunol 2018 Nov 30:e13074. Epub 2018 Nov 30.

First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China.

Problem: The role of the long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) in the etiology of endometriosis is unknown.

Method Of Study: Expression of epithelial-mesenchymal transition (EMT) markers was quantified using qRT-PCR, immunohistochemistry, and western blotting. The proliferation, migration, and invasion of ectopic endometrial epithelial cells and Ishikawa cells were evaluated by MTT, EdU, wound healing, and transwell assays. Read More

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November 2018
1 Read

"When you hear hoofbeats, think of horses not zebras": a case of bladder endometriosis in menopause.

J Minim Invasive Gynecol 2018 Nov 29. Epub 2018 Nov 29.

Department of Obstetrics and Gynecology of Macedonio Melloni Hospital, University of Milan, Milan, Italy.

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November 2018

Assisted reproduction in endometriosis.

Best Pract Res Clin Endocrinol Metab 2018 Nov 3. Epub 2018 Nov 3.

Department of Obstetrics and Gynecology, Hôpital Foch - Université de Paris Ouest (UVSQ), France.

Endometriosis - a disease causing pain and infertility - is encountered in nearly 50% of infertile women. While medical treatment is effective on pain and recurrence of symptoms after surgical excision, it is of no help for treating infertility for which the only options considered are surgery and ART. Surgery enhances the chances of conceiving naturally during the 12-18 ensuing months irrespective of the stage of the disease. Read More

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November 2018

Invasion of human deep nodular endometriotic lesions is associated with collective cell migration and nerve development.

Fertil Steril 2018 Dec;110(7):1318-1327

Institut du Sein et de Chirurgie Gynécologique d'Avignon, Polyclinique Urbain V (ELSAN Group), Avignon, France.

Objective: To study the mechanisms of invasion and innervation of deep endometriosis in women.

Design: Morphologic and immunohistochemical analysis of human endometriotic lesions.

Setting: Academic research unit. Read More

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December 2018

[CLINICAL FEATURES OF ENDOMETRIOSIS IN WOMEN IN PERIMENOPAUSE].

Georgian Med News 2018 Oct(283):26-29

Institute of Pediatrics, Obstetrics and Gynecology named E.M. Lukyanova of the NAS of Ukraine, Department of Endocrine Gynecology; State Clinical Hospital N9, Department of Gynecology, Kiev, Ukraine.

The aim of the research is the assessment of the features of the course of endometriosis in women in perimenopause. The exanimated group of patients consisted of 106 women with endometriosis and climacteric syndrome and 64 women with endometriosis without climacteric syndrome. The comparison group consisted of 70 women without endometriosis and symptoms of climacteric syndrome. Read More

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October 2018

Evaluation of ovarian cancer risk in granulosa cells treated with steroid-depleted endometriosis serum: Role of NF-κB/RelA and AKT.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Despite at the beginning known as a benign disease, endometriosis is defined as a risk factor for developing ovarian carcinoma. The effect of endometriosis on ovarian malignancy is known but its role in granulosa cell tumor is still unclear.

Methods And Materials: In this study, serum samples were collected from patients with endometriosis and divided into whole and steroid-depleted groups. Read More

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December 2018
1 Read

Impaired Localization of Claudin-11 in Endometriotic Epithelial Cells Compared to Endometrial Cells.

Reprod Sci 2018 Dec 4:1933719118811643. Epub 2018 Dec 4.

1 Department of Gynecology and Obstetrics, University of Giessen, Giessen, Germany.

Claudins are the major components of tight junctions and are often deregulated in human cancer, permitting escape of cancer cells along with the acquisition of invasive properties. Similarly, endometrial cells also show invasive capabilities; however, the role of tight junctions in endometriosis has only rarely been examined. In this study, we analyzed the protein expression and localization of claudin-7 and claudin-11 in human eutopic and ectopic endometrium and endometrial cell lines. Read More

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December 2018

[Research progress on oxidative stress in pathogenesis of endometriosis].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):419-425

Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.

A large number of studies have shown that the oxidative imbalance is common in patients with endometriosis. Abnormal respiratory chain of mitochondrial, estrogen metabolism imbalance, iron overload, and ectopic foci may increase active oxygen, reduction of antioxidant enzyme and non-enzymatic substances may result in decreased antioxidant level, and the exposure to environmental hazards may further aggravate oxidative imbalance in patients with endometriosis. This article analyzes the oxidative imbalance and its role in the pathogenesis of endometriosis from the aspects of excessive oxide production and decreased antioxidant capacity. Read More

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February 2018
2 Reads

[Research progress on roles of vitamin D in endometriosis].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):413-418

Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.

In addition to regulating calcium and phosphorus metabolism to maintain strong bones, vitamin D also has immune regulating and anti-inflammatory effects. Moreover, it is related to chronic inflammatory diseases, autoimmune diseases and cancer. Many studies indicate the roles of vitamin D in the development and progression of endometriosis including the effects on modulation of immune responses, inflammation reactions, cell proliferation and apoptosis, angiogenesis, adhesion and invasion. Read More

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February 2018
2 Reads

The Clinical Anatomy of Endometriosis: A Review.

Cureus 2018 Sep 25;10(9):e3361. Epub 2018 Sep 25.

Neurosurgery, Seattle Science Foundation, Seattle, USA.

Endometriosis is a gynecological disorder identified by the presence of ectopic endometrial tissue outside the uterus. Largely, it affects reproductive-aged women and is a major cause of infertility. Clinical manifestations of endometriosis include dyspareunia, cyclic menstrual pain, chronic pelvic pain, and dyschezia, all of which can affect the patient's quality of life and health severely; therefore, it is paramount that medical treatment is initiated as soon as endometriosis is suspected clinically. Read More

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September 2018
1 Read

Investigating the photo-thermo-radiosensitization effects of folate-conjugated gold nanorods on KB nasopharyngeal carcinoma cells.

Photodiagnosis Photodyn Ther 2018 Dec 27;24:324-331. Epub 2018 Oct 27.

Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran. Electronic address:

In this article, we report a targeted cancer treatment strategy using nano-photo-thermal therapy (NPTT) and radiotherapy (RT) methods. Gold nanorods (AuNRs) without and with folic acid (FA) conjugation were firstly synthesized and then characterized. Cytotoxicity of various methods; NPTT (nanoparticles; 808 nm laser; 2 W/cm) or RT (6 MV X-ray; 2 Gy) or combination of NPTT and RT; was separately investigated on KB nasopharyngeal carcinoma cells. Read More

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December 2018
1 Read

Estradiol promotes EMT in endometriosis via MALAT1/miR200s sponge function.

Reproduction 2018 Nov 1. Epub 2018 Nov 1.

L Zhang, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Endometriosis is an estrogen-dependent benign gynecological disease that shares some common features of malignancy. Epithelial-mesenchymal transition (EMT) has been recognized as a core mechanism of endometriosis. MALAT1 is widely known as EMT promoter, while miR200 family members (miR200s) are considered as EMT inhibitors. Read More

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November 2018

Dimethyloxalylglycine preconditioning enhances protective effects of bone marrow-derived mesenchymal stem cells in Aβ- induced Alzheimer disease.

Physiol Behav 2018 Nov 27;199:265-272. Epub 2018 Nov 27.

Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Iran; Neurophysiology Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

Mesenchymal stem cell (MSC) transplantation therapy has been proposed as a promising approach for the treatment of neurodegenerative disease. Chemical and pharmacological preconditioning before transplantation could optimize the therapeutic properties of transplanted MSCs. In this study, we hypothesized that preconditioning treatment with a prolyl hydroxylase inhibitor, dimethyloxalylglycine (DMOG), will increase MSC efficacy and paracrine effects in an amyloid-β (Aβ)-injected Alzheimer rat model. Read More

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November 2018

Abnormally located SSEA1+/SOX9+ endometrial epithelial cells with a basalis-like phenotype in the eutopic functionalis layer may play a role in the pathogenesis of endometriosis.

Hum Reprod 2018 Nov 29. Epub 2018 Nov 29.

Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia.

Study Question: Is endometriosis associated with abnormally located endometrial basalis-like (SSEA1+/SOX9+) cells in the secretory phase functionalis and could they contribute to ectopic endometriotic lesion formation?

Summary Answer: Women with endometriosis had an abnormally higher number of basalis-like SSEA1+/SOX9+ epithelial cells present in the stratum functionalis and, since these cells formed 3D structures in vitro with phenotypic similarities to ectopic endometriotic lesions, they may generate ectopic lesions following retrograde menstruation.

What Is Known Already: Endometrial basalis cells with progenitor potential are postulated to play a role in the pathogenesis of endometriosis and SSEA1 and nuclear SOX9 (nSOX9) mark basalis epithelial cells that also have some adenogenic properties in vitro. Induction of ectopic endometriotic lesions in a baboon model of endometriosis produces characteristic changes in the eutopic endometrium. Read More

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November 2018

Knockdown of long non-coding RNA CCDC144NL-AS1 attenuates migration and invasion phenotypes in endometrial stromal cells from endometriosis.

Biol Reprod 2018 Nov 28. Epub 2018 Nov 28.

Center of Gynecologic Oncology, Peking University People's Hospital, Beijing, China.

Endometriosis (EM) is a mysterious and complicated disease that has been found to be multifactorial. Recent studies demonstrated that long noncoding RNAs (lncRNAs) play an important role in the pathogenesis of EM. However, the functional and biological mechanisms of lncRNAs in EM remain unknown. Read More

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November 2018
3.318 Impact Factor

Satisfaction with medical support in women with endometriosis.

PLoS One 2018 29;13(11):e0208023. Epub 2018 Nov 29.

Department of Reproductive Endocrinology, University Hospital Zurich, Zurich, Switzerland.

Endometriosis affects various aspects of women's lives. We searched for predictors for patient satisfaction with medical support (PSwMS) in women with endometriosis. The study was designed as a multi-centre retrospective cohort study. Read More

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November 2018

CA125 measured during menstruation can be misleading.

Ir Med J 2018 Apr 19;111(4):738. Epub 2018 Apr 19.

Merrion Fertility Clinic, 60 Mount Street, Dublin 2

The aim of these case reports and literature review is to report the importance of cyclical variation of serum CA-125 levels in two patients with endometriosis. Two case reports and a literature review of cyclical variation in serum CA-125 levels are discussed. There was significant variation in serum CA-125 levels taken during menses and mid-cycle in these two cases. Read More

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Integrated Eutopic Endometrium and Non-Depleted Serum Quantitative Proteomic Analysis Identifies Candidate Serological Markers of Endometriosis.

Proteomics Clin Appl 2018 Nov 28:e1800153. Epub 2018 Nov 28.

Human Development and Health, University of Southampton, Southampton, SO16, UK.

Background: Endometriosis affects about 4% of women in the reproductive age and is associated with subfertility. The aim of the present study is to examine the integrated quantitative proteomic profile of eutopic endometrium and serum from women with endometriosis compared to controls in order to identify candidate disease-specific serological markers.

Methods: Eutopic endometrium and serum from patients with endometriosis (n = 8 for tissue and n = 4 for serum) are, respectively, compared to endometrium and serum from females without endometriosis (n = 8 for tissue and n = 4 for serum) using a shotgun quantitative proteomics method. Read More

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November 2018
2.680 Impact Factor

Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375.

Int J Mol Sci 2018 Nov 28;19(12). Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, 50090 Tartu, Estonia.

microRNA (miRNA) expression level alterations between endometrial tissue and endometriotic lesions indicate their involvement in endometriosis pathogenesis. However, as both endometrium and endometriotic lesions consist of different cell types in various proportions, it is not clear which cells contribute to variability in miRNA levels and the overall knowledge about cell-type specific miRNA expression in ectopic cells is scarce. Therefore, we utilized fluorescence-activated cell sorting to isolate endometrial stromal cells from paired endometrial and endometrioma biopsies and combined it with high-throughput sequencing to determine miRNA alterations in endometriotic stroma. Read More

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November 2018

Increased Expression Levels of Metalloprotease, Tissue Inhibitor of Metalloprotease, Metallothionein, and p63 in Ectopic Endometrium: An Animal Experimental Study.

Rev Bras Ginecol Obstet 2018 Nov 28;40(11):705-712. Epub 2018 Nov 28.

Faculty of Medicine, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

Objective:  To characterize the patterns of cell differentiation, proliferation, and tissue invasion in eutopic and ectopic endometrium of rabbits with induced endometriotic lesions via a well- known experimental model, 4 and 8 weeks after the endometrial implantation procedure.

Methods:  Twenty-nine female New Zealand rabbits underwent laparotomy for endometriosis induction through the resection of one uterine horn, isolation of the endometrium, and fixation of tissue segment to the pelvic peritoneum. Two groups of animals (one with 14 animals, and the other with15) were sacrificed 4 and 8 weeks after endometriosis induction. Read More

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November 2018
1 Read

Changes in the incidence and uptake of reproductive surgery versus in vitro fertilisation in Australia between 2001 and 2015: A population-based study.

Aust N Z J Obstet Gynaecol 2018 Nov 28. Epub 2018 Nov 28.

School of Mathematics and Applied Statistics, The University of Wollongong, Wollongong, New South Wales, Australia.

Objective: Improvements in success rates of assisted reproduction led to predictions that infertility surgery in both women and men would become extinct in developed countries. We sought to identify the changes in reproductive surgery that occurred between 2001 and 2015 to determine whether these predictions have been accurate.

Design: The Australian Institute of Health and Welfare (AIHW) national procedural dataset and the Australian Medicare Benefits Scheme (MBS) claims database were searched for procedure data for male and female reproductive surgery and assisted reproduction from January 2001 to December 2015. Read More

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November 2018

Fertility experiences in women reporting endometriosis: findings from the Understanding Fertility Management in Contemporary Australia survey.

Eur J Contracept Reprod Health Care 2018 Nov 27:1-7. Epub 2018 Nov 27.

a School of Public Health and Preventive Medicine , Monash University , Melbourne , Australia.

Purpose: To examine the fertility experiences of women reporting and not reporting endometriosis in a population-based survey.

Materials And Methods: A cross-sectional survey among a community sample of 1543 women in Australia. Data were analysed to compare fertility management between women who did and did not report endometriosis. Read More

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November 2018
1 Read

How to assess the ureters during pelvic ultrasound.

Ultrasound Obstet Gynecol 2018 Nov 26. Epub 2018 Nov 26.

Institute of Women's Health, University College London Hospital 235 Euston Road, London, NW1 2BU.

Background: Endometriosis, fibroids and gynecological malignancy can all impact the pelvic ureters. Ureteric involvement is likely to be an important factor in determining the extent and timing of surgery in women with these conditions and assessment of the pelvic ureters is now a recommended component of the imaging work-up for women with endometriosis. The aim of this paper is to provide a step-by-step guide for the identification and assessment of the distal ureters during pelvic ultrasound. Read More

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November 2018
7 Reads

Cervico-vaginal secretion cytokine profile: A non-invasive approach to study the endometrial receptivity in IVF cycles.

Am J Reprod Immunol 2018 Nov 26:e13064. Epub 2018 Nov 26.

Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.

Problem: Cytokines have a significant role in the process of embryo implantation, trophoblast growth, and differentiation by modulating the immune and endocrine system. The aim of this study was to investigate the profile of a large set of cytokines in the cervico-vaginal washing of women undergoing IVF, to explore the association of these proteins with a good receptive endometrium.

Method Of Study: A cohort of 155 women scheduled for IVF cycle was recruited. Read More

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November 2018
5 Reads

Supernumerary ovary on recto-sigmoid colon with associated endometriosis.

Obstet Gynecol Sci 2018 Nov 11;61(6):702-706. Epub 2018 Oct 11.

Department of Obstetrics and Gynecology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.

A supernumerary ovary is a rare gynecological anomaly, and is usually excised due to its malignant transformation potential. We report a case of a supernumerary ovary and endometriosis situated on the anterior rectosigmoid colon. When laparoscopy was conducted, a firm, 5-cm mass was discovered on the anterior rectosigmoid colon along with normal ovaries. Read More

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November 2018
2 Reads

Recent advances in imaging and understanding interstitial cystitis.

F1000Res 2018 9;7. Epub 2018 Nov 9.

Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating condition associated with intense pelvic pain and bladder storage symptoms. Since diagnosis is difficult, prevalence estimates vary with the methodology used. There is also a lack of proven imaging tools and biomarkers to assist in differentiation of IC/BPS from other urinary disorders (overactive bladder, vulvodynia, endometriosis, and prostatitis). Read More

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November 2018
1 Read

The pregnancy outcomes of intrauterine insemination with husband's sperm in natural cycles versus ovulation stimulated cycles: A retrospective study.

Biosci Trends 2018 ;12(5):463-469

Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University.

To compare the clinical outcomes of intrauterine insemination (IUI) with or without ovulation induction (OI), IUI cycles from January 2008 to December 2017 in Zhoushan Maternity and Child Healthcare Hospital were included, consisting of 455 natural cycles and 536 OI cycles. The overall clinical pregnancy rate did not differ between the two groups (P > 0.05). Read More

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January 2018
4 Reads

N 164 - Directive clinique de consensus pour la prise en charge de la douleur pelvienne chronique.

J Obstet Gynaecol Can 2018 Nov;40(11):e788-e836

Calgary, Alb.

Objectif: Améliorer La compréhension de la douleur pelvienne chronique (DPC) et fournir des directives cliniques factuelles qui bénéficieront aux fournisseurs de soins de santé primaires, aux obstétriciens-gynécologues et aux spécialistes de la douleur chronique.

Fardeau De La Souffrance: La DPC est une pathologie débilitante courante qui affecte les femmes. Elle est à l'origine d'importantes souffrances personnelles et de dépenses de santé considérables associées aux interventions, dont de multiples consultations et un grand nombre de traitements médicaux et chirurgicaux. Read More

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November 2018
1 Read

No. 164-Consensus Guidelines for the Management of Chronic Pelvic Pain.

J Obstet Gynaecol Can 2018 Nov;40(11):e747-e787

Calgary, AB.

Objective: To improve the understanding of chronic pelvic pain (CPP) and to provide evidence-based guidelines of value to primary care health professionals, general obstetricians and gynaecologists, and those who specialize in chronic pain.

Burden Of Suffering: CPP is a common, debilitating condition affecting women. It accounts for substantial personal suffering and health care expenditure for interventions, including multiple consultations and medical and surgical therapies. Read More

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November 2018
3 Reads

Reduced pain thresholds and signs of sensitization in women with persistent pelvic pain and suspected endometriosis.

Acta Obstet Gynecol Scand 2018 Nov 25. Epub 2018 Nov 25.

Department of Obstetrics and Gynecology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Introduction: Endometriosis is a gynecological disorder that may cause considerable pelvic pain in women of fertile age. Determining pain mechanisms is necessary in order to optimize the treatment of the disease. The objective of the study was to evaluate pain thresholds in women with persistent pelvic pain with and without confirmed endometriosis, and healthy, unaffected controls, and analyze how pain thresholds in these cohorts related to duration of pelvic pain, quality of life, and symptoms of anxiety and depression. Read More

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November 2018
8 Reads

Müllerian aplasia with severe hematometra: A case report of diagnosis and management in a low resource setting.

J Pediatr Adolesc Gynecol 2018 Nov 21. Epub 2018 Nov 21.

Department of Obstetrics and Gynecology University of Iowa Carver College of Medicine 200 Hawkins Dr. Iowa City, IA 52241.

Background: Müllerian aplasia or Mayer-Rokitansky-Küster-Hauser syndrome is described as congenital absence of the proximal vagina with or without absence of the cervix and uterus, most often recognized following the onset of primary amenorrhea.

Case: An 18-year-old female presented to a free medical clinic in Arcahaie, Haiti with primary amenorrhea, abdominal distention and cyclic monthly abdominal pain. Physical exam was significant for uterus palpable superior to the umbilicus, absence of vagina, and rectal exam without palpable vagina or cervix. Read More

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November 2018
3 Reads

Urinary 8-Hydroxy-2'-deoxyguanosine (8-OHdG) Concentrations and Menstrual Cycle Characteristics in Female University Students.

Int J Environ Res Public Health 2018 Nov 22;15(12). Epub 2018 Nov 22.

Faculty of Nursing, Tokyo Healthcare University, 2-5-1 Higashigaoka, Meguro, Tokyo 152-8558, Japan.

Higher concentrations of oxidative stress biomarkers are found in women with polycystic ovary syndrome (PCOS) and endometriosis, conditions linked to irregular menstrual cycles and menstrual pain. The aim of the present study was to test whether women with higher oxidative stress are more likely to show irregular menstrual cycles and severe menstrual pain compared with women with lower oxidative stress. A cross-sectional study was conducted targeting female university students with a mean (SD) age of 20. Read More

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November 2018
2 Reads

Diverting stoma-related complications following colorectal endometriosis surgery: a 163-patient cohort.

Eur J Obstet Gynecol Reprod Biol 2018 Nov 6;232:46-53. Epub 2018 Nov 6.

Expert Center in the Diagnosis and Multidisciplinary Management of Endometriosis, Rouen University Hospital, Rouen, France; Clinique Tivoli-Ducos, Bordeaux, France. Electronic address:

Objective: Deep endometriosis may simultaneously infiltrate the vagina and the rectosigmoid, which associated resection may increase the risk of postoperative complications. Among these complications, rectovaginal fistula is one of the worst. To reduce the risk of rectovaginal fistula and related complications, surgeons may employ diverting stoma. Read More

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November 2018
4 Reads

Cai's Neiyi Prescription promotes apoptosis and inhibits inflammation in endometrial stromal cells with endometriosis through inhibiting USP10.

Biotechnol Appl Biochem 2018 Nov 23. Epub 2018 Nov 23.

Department of Traditional Chinese Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

To observe the effect of Cai's Neiyi Prescription (CNYP) on the apoptosis and inflammation in endometrial stromal cells with endometriosis (EM) both in vivo and in vitro, EM model rats and endometrial stromal cells were treated with CNYP and the level of USP10, p-ERK1/2, ERK1/2, and apoptosis-related protein as well as the levels of proinflammatory factors were measured by Western blotting and ELISA, respectively. Rats with surgically induced EM showed increased USP10 expression and ERK/2 activation. Intragastric administration of CNYP granule significantly inhibited EM-induced ERK1/2 activation and expression of USP10 and Bcl-2, but increased the expression of Bax and Caspase-7 in EM-induced rats. Read More

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November 2018
2 Reads

Correction to: Long-term treatment of endometriosis with dienogest: retrospective analysis of efficacy and safety in clinical practice.

Authors:
Thomas Römer

Arch Gynecol Obstet 2018 Nov 22. Epub 2018 Nov 22.

Obstetrics and Gynecology Department, Academic Hospital Weyertal, University of Cologne, 50931, Cologne, Germany.

In the original publication of the article, the word laparotomy has been presented in the proofs instead of laparoscopy in the below places. Read More

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November 2018
6 Reads

Clinical comparison of mifepristone and gestrinone for laparoscopic endometriosis.

Pak J Pharm Sci 2018 Sep;31(5(Special)):2197-2201

Department of Centerfor Reproductive Medicine, The Affiliated Yantai Yuhuangding Hospital of Medical College, Qingdao University, Yantai, China.

Endometriosis is a common disease among women of childbearing age, and it is the main cause of dysmenorrhea and infertility. This article analyzes the efficacy of mifepristone and gestrinone in the treatment of endometriosis. The results showed that the recurrence rate of mifepristone group and gestrinone group were 8. Read More

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September 2018
2 Reads

ACOG Committee Opinion No. 760: Dysmenorrhea and Endometriosis in the Adolescent.

Authors:

Obstet Gynecol 2018 Dec;132(6):e249-e258

Dysmenorrhea, or menstrual pain, is the most common menstrual symptom among adolescent girls and young women. Most adolescents experiencing dysmenorrhea have primary dysmenorrhea, defined as painful menstruation in the absence of pelvic pathology. When the patient's history suggests primary dysmenorrhea, empiric treatment should be initiated. Read More

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December 2018
5 Reads

ACOG Committee Opinion No. 760 Summary: Dysmenorrhea and Endometriosis in the Adolescent.

Authors:

Obstet Gynecol 2018 Dec;132(6):1517-1518

Dysmenorrhea, or menstrual pain, is the most common menstrual symptom among adolescent girls and young women. Most adolescents experiencing dysmenorrhea have primary dysmenorrhea, defined as painful menstruation in the absence of pelvic pathology. When the patient's history suggests primary dysmenorrhea, empiric treatment should be initiated. Read More

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December 2018
4 Reads

Dienogest for Treatment of Endometriosis in Women: A 28-Week, Open-Label, Extension Study.

J Womens Health (Larchmt) 2018 Nov 21. Epub 2018 Nov 21.

1 Peking Union Medical College Hospital , Beijing, People's Republic of China .

Background: Dienogest provided significantly greater reduction in endometriosis-associated pelvic pain (EAPP) than placebo in a 24-week, randomized, double-blind study of Chinese women with endometriosis. The current open-label extension study investigated the efficacy and safety of dienogest for 28 additional weeks in this population.

Patients And Methods: Women with endometriosis were eligible to enroll at completion of the 24-week, placebo-controlled study (n = 220). Read More

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November 2018
2 Reads

Route of hysterectomy: a retrospective, cohort study in English NHS Hospitals from 2011-2017.

BJOG 2018 Nov 20. Epub 2018 Nov 20.

Department of Gynaecology, Poole Hospital NHS Trust, Dorset, UK.

Objective: To assess variation in the route of hysterectomy over 7-years and to assess regional variation in practice.

Design: Retrospective cohort study.

Setting: EnglishaNHSaHospitalsa2011-2017. Read More

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November 2018
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Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis.

Arch Gynecol Obstet 2018 Nov 20. Epub 2018 Nov 20.

Department of Oncology, Weifang Medical College Affiliated Hospital, No. 465, Yuhe Road, Kuiwen District, Weifang, ShanDong, China.

Purpose: The risks of gynecologic cancer have not been well established in women with endometriosis. The objective of the present study was to investigate the influence of endometriosis on the risk for three gynecologic cancer (ovarian cancer, endometrial cancer and cervical cancer).

Methods: We gathered updated evidence about the risk relationship between endometriosis and gynecologic cancers by conducting a comprehensive search of several medical literature electronic databases, including PubMed, Embase and the Cochrane Library. Read More

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November 2018
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Clinical presentation and treatment of catameinal pneumothorax and endometriosis-related pneumothorax.

Expert Rev Respir Med 2018 Nov 20:1-6. Epub 2018 Nov 20.

a Thoracic surgery department, Paris center hospitals , University Paris Descartes, APHP , Paris , France.

Introduction: Catamenial pneumothorax (CP) is defined as a recurrent spontaneous pneumothorax occurring in females of reproductive age. In the 'perimenstrual period,' it is still considered relatively rare although accounting for 20-35% of spontaneous pneumothoraces occurring in premenopausal women. It is the most frequent manifestation of thoracic endometriosis, which can also cause pneumothorax during the intermenstrual period (TER non-CP). Read More

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November 2018
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