27,929 results match your criteria Endometriosis


Improvement in quality of life and pain scores after laparoscopic management of deep endometriosis: a retrospective cohort study.

Arch Gynecol Obstet 2020 May 23. Epub 2020 May 23.

Endometriosis Center, Acibadem Fulya Hospital, Istanbul, Turkey.

Purpose: This is a retrospective cohort study that evaluates the postoperative pain findings of a consecutive series of laparoscopic surgeries for deep endometriosis (DE).

Methods: This multi-center retrospective cohort study was carried out in university hospitals (Istanbul, Turkey). Sixty-five patients diagnosed through bimanual gynecologic examination, gynecologic ultrasound or magnetic resonance imaging-confirmed endometrioma and DE together; who underwent a laparoscopic surgery between 2013 and 2019 by a team of gynecologists, colorectal surgeons, and a urologist were retrospectively evaluated. Read More

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http://dx.doi.org/10.1007/s00404-020-05583-6DOI Listing

Laparoscopic sclerotherapy of large endometriomas: is it a reasonable approach?

Authors:
Horace Roman

J Minim Invasive Gynecol 2020 May 21. Epub 2020 May 21.

Endometriosis Center, Clinique Tivoli-Ducos, 33000 Bordeaux, France; Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jmig.2020.05.011DOI Listing

The impact of vascular endothelial growth factor single nucleotide polymorphisms in the development and severity of endometriosis: a systematic review of the literature.

J Gynecol Obstet Hum Reprod 2020 May 21:101732. Epub 2020 May 21.

First Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Greece.

Objective: To review the impact of single nucleotide polymorphisms (SNPs) of the vascular endothelial growth factor (VEGF) gene in the development and severity of endometriosis.

Search Strategy: We searched Medline, Scopus, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL and Google Scholar databases for published studies in the field. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101732DOI Listing

LncRNA MEG3-210 regulates endometrial stromal cells migration, invasion and apoptosis through p38 MAPK and PKA/SERCA2 signalling via interaction with Galectin-1 in endometriosis.

Mol Cell Endocrinol 2020 May 21:110870. Epub 2020 May 21.

Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, PR China. Electronic address:

Background: Endometriosis is a benign gynaecological disease with malignant characteristics that severely affects women's quality of life. Long noncoding RNA maternally expressed gene 3 (LncRNA MEG3) is a tumour suppressor that is downregulated in various cancer cells and tissues, and regulates multiple biological processes. Emerging studies have revealed that the interactions between MEG3 and proteins are involved in disease progression. Read More

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http://dx.doi.org/10.1016/j.mce.2020.110870DOI Listing

Exploratory Analysis of CA125-MGL and -STn Glycoforms in the Differential Diagnostics of Pelvic Masses.

J Appl Lab Med 2020 Mar;5(2):263-272

Institute of Biomedicine, Research Center for Cancer, Infections and Immunity, Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland.

Background: The cancer antigen 125 (CA125) immunoassay (IA) does not distinguish epithelial ovarian cancer (EOC) from benign disease with the sensitivity needed in clinical practice. In recent studies, glycoforms of CA125 have shown potential as biomarkers in EOC. Here, we assessed the diagnostic abilities of two recently developed CA125 glycoform assays for patients with a pelvic mass. Read More

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http://dx.doi.org/10.1093/jalm/jfz012DOI Listing

Oestrogen receptors and hypoxia inducible factor 1 alpha expression in abdominal wall endometriosis.

Reprod Biomed Online 2020 Apr 19. Epub 2020 Apr 19.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Research Question: What are the protein levels and localization of oestrogen receptors (including ERa, ERb and G protein-coupled oestrogen receptor [GPER]) and hypoxia-inducible factor-1alpha (HIF-1a) in normal control endometrium (COEM) and ectopic endometrium from abdominal wall endometriosis (AWE).

Design: AWE (n = 20) were obtained during surgery; COEM (n = 40) were collected by curettage. All tissues were obtained during the proliferative or secretory phase. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.03.006DOI Listing

Vitamin D-Binding Protein in Pregnancy and Reproductive Health.

Nutrients 2020 May 20;12(5). Epub 2020 May 20.

Monash Centre for Health Research and Implementation (MCHRI) and Centre of Cardiovascular Research and Education in Therapeutics (CCRET), School of Public Health and Preventive Medicine, Monash University, Melbourne 3168 VIC, Australia.

Vitamin D-binding protein (VDBP), the main carrier of vitamin D, has recently been implicated in reproductive health and pregnancy outcomes including endometriosis, polycystic ovary syndrome (PCOS), pre-eclampsia, and gestational diabetes mellitus (GDM). Improved methods for measuring VDBP and an increased understanding of its role in biological processes have led to a number of newly published studies exploring VDBP in the context of pregnancy. Here, we synthesize the available evidence regarding the role of VDBP in reproductive health and pregnancy, and we highlight areas requiring further study. Read More

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http://dx.doi.org/10.3390/nu12051489DOI Listing

Indocyanine green-guided, ureteric preserving, laparoscopic Hartmann's procedure for obstructing colonic adenocarcinoma with endometriosis - a video vignette.

Colorectal Dis 2020 May 22. Epub 2020 May 22.

Unit of Innovation in Minimally Invasive Surgery, Department of General and Digestive Surgery, University Hospital "Virgen del Rocio", Sevilla, Spain.

Indocyanine green (ICG) fluorescence has been introduced recently to minimally invasive surgery as useful tool to determine vascular supply and also to identify anatomical structures. In colorectal surgery it is mainly used to assess adequate perfusion of a proposed anastomosis and also to identify lymph nodes, including the sentinel node. ICG fluorescence also can be of use in unexpected anatomical situations or to prevent iatrogenic injury, particularly to the ureter. Read More

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http://dx.doi.org/10.1111/codi.15149DOI Listing

ROBOTIC ASSISTED NERVE-SPARING RESECTION OF BILATERAL PARAMETRIAL DEEP INFILTRATING ENDOMETRIOSIS.

J Minim Invasive Gynecol 2020 May 19. Epub 2020 May 19.

Department of Human Pathology of the Adult and of the Childhood "Gaetano Barresi", Università di Messina, Messina, Italy.

Study Objective: To demonstrate the surgical steps used to perform a robotic radical parametrectomy in a woman with deep infiltrating endometriosis DESIGN: Description of the procedure using video.

Setting: A university hospital, referral center for endometriosis and minimally invasive surgery.

Intervention: A 47 years old woman, BMI 31, who underwent supracervical hysterectomy for fibromatosis 5 years before. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.05.009DOI Listing

Bioinformatic analysis reveals the importance of epithelial-mesenchymal transition in the development of endometriosis.

Sci Rep 2020 May 21;10(1):8442. Epub 2020 May 21.

Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, SO17 1BJ, UK.

Background: Endometriosis is a frequently occurring disease in women, which seriously affects their quality of life. However, its etiology and pathogenesis are still unclear.

Methods: To identify key genes/pathways involved in the pathogenesis of endometriosis, we recruited 3 raw microarray datasets (GSE11691, GSE7305, and GSE12768) from Gene Expression Omnibus database (GEO), which contain endometriosis tissues and normal endometrial tissues. Read More

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http://dx.doi.org/10.1038/s41598-020-65606-9DOI Listing

Posterior rectal pouch after large full-thickness disc excision of deep endometriosis infiltrating the low/mid rectum and relationship with digestive functional outcome.

J Gynecol Obstet Hum Reprod 2020 May 18:101792. Epub 2020 May 18.

Endometriosis Center, Clinique Tivoli-Ducos, 33000, Bordeaux, France; Department of Gynecology, Aarhus Medical University, Aarhus, Denmark. Electronic address:

Introduction: The aim of our study is to describe MRI appearance of a posterior rectal pouch (PRP) for patients managed for low rectal endometriosis by large full-thickness disc excision and to assess its relationship with postoperative functional digestive symptoms.

Material And Methods: Single center retrospective study including patients managed by low/mid rectal disc excision using a semi-circular stapler (the Rouen technique) from June 2009 to October 2016. Intraoperative findings and data provided by standardized gastrointestinal self-questionnaires (GIQLI, KESS, Wexner and Bristol), before and 1 year after the surgery, were prospectively recorded. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101792DOI Listing

Mitochondrial Function in Modulating Human Granulosa Cell Steroidogenesis and Female Fertility.

Int J Mol Sci 2020 May 19;21(10). Epub 2020 May 19.

Ph.D. Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.

Ovarian follicle steroidogenesis associated with embryo quality results in a successful pregnancy. Each follicle consists of an oocyte surrounded by granulosa cells, which secrete several steroid and peptide hormones. Follicles harvested from women who conceived after assisted reproductive therapy (ART) had significantly higher estradiol levels in follicular fluids than the follicles from women who failed to conceive after ART. Read More

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http://dx.doi.org/10.3390/ijms21103592DOI Listing

Expert Opinion: Broken Play Laparoscopy - What to do when there's no findings?

Authors:
Greg J Marchand

Eur J Obstet Gynecol Reprod Biol 2020 May 7;250:124-125. Epub 2020 May 7.

Marchand Institute for Minimally Invasive Surgery, 10238 E. Hampton, Ste 212, Mesa, AZ 85209, USA(1). Electronic address:

A short review of the uncomfortable scenario of a negative laparoscopy when expecting endometriosis, adhesive disease or other pathology. The article reviews different commonly used but rarely documented strategies for ameliorating pelvic pain in the absence of clear pathology. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.03.037DOI Listing

Classification algorithm of patients with endometriosis: Proposal for tailored management.

Adv Clin Exp Med 2020 May 21. Epub 2020 May 21.

Gynecology and Obstetrics, Department of Surgical Sciences, City of Health and Science, University of Torino, Italy.

Endometriosis is a pseudoneoplastic disease that has a significant personal and social impact. Unlike other neoplastic diseases, its management is burdened by uncertainty and controversy. The aim of this article is to furnish clinicians with a simple, useful and updated tool to select an appropriate diagnostic-therapeutic care pathway for affected women. Read More

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http://dx.doi.org/10.17219/acem/118849DOI Listing

Effect of hysterectomy on pain in patients with endometriosis: A population-based registry study.

BJOG 2020 May 21. Epub 2020 May 21.

Department of Clinical Sciences, Obstetrics and Gynaecology, Umea University, SE-90185, Umea, Sweden.

Objective: To assess pain symptoms before and after hysterectomy in women with endometriosis.

Design: A population-based registry study.

Setting: Sweden. Read More

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http://dx.doi.org/10.1111/1471-0528.16328DOI Listing

Suppression of PRDX4 inhibits cell proliferation and invasion of ectopic endometrial stromal cells in endometriosis.

Gynecol Endocrinol 2020 May 21:1-7. Epub 2020 May 21.

Department of Gynecology, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, China.

Oxidative stress (OS) has been proposed to play a role in the development of EMs. Peroxiredoxins are a family of antioxidant proteins that exhibit peroxidase activity in a thioredoxin-dependent manner, protecting cells against OS. The Western blotting results showed that the relative expression of PRDX4 was significantly increased in ectopic endometria compared with the normal endometria of EMs-free ( < . Read More

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http://dx.doi.org/10.1080/09513590.2020.1768369DOI Listing

IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis.

Reprod Sci 2020 May 20. Epub 2020 May 20.

Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan.

When the presence of endometriotic lesions are not evident by hematoxylin and eosin staining, CD10 is used to highlight and confirm the presence of endometriotic stroma. However, CD10 is not specific only to the endometrial stroma but is also expressed in many other cells. Recently, interferon-inducible transmembrane protein 1 (IFITM1) was reported as a highly specific immunohistochemical marker of normal endometrial stroma and endometrial stromal neoplasm. Read More

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http://dx.doi.org/10.1007/s43032-020-00189-4DOI Listing

Correction to: miR-205-5p inhibits human endometriosis progression by targeting ANGPT2 in endometrial stromal cells.

Stem Cell Res Ther 2020 May 20;11(1):188. Epub 2020 May 20.

Department of Obstetrics and Gynecology, Zhujiang Hospital of Southern Medical University, No.253, Middle Gongyeda Road, Haizhu District, Guangzhou, 510280, China.

An amendment to this paper has been published and can be accessed via the original article. Read More

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http://dx.doi.org/10.1186/s13287-020-01686-8DOI Listing

Lesion distribution characteristics of deep infiltrating endometriosis with ovarian endometrioma: an observational clinical study.

BMC Womens Health 2020 May 20;20(1):111. Epub 2020 May 20.

Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.

Background: To investigate the characteristics of deep infiltrating endometriosis (DIE) lesion distribution when associated with ovarian endometrioma (OEM).

Methods: The present study analyzed retrospective data obtained by the First Affiliated Hospital of Sun Yat-sen University, between June 2008 to June 2016. A total of 304 patients underwent laparoscopic surgery for complete removal of endometriosis by one experienced surgeon, and histological confirmation of OEM associated with DIE was conducted for each patient. Read More

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http://dx.doi.org/10.1186/s12905-020-00974-yDOI Listing

Inflammation calls for more: Severe pelvic inflammatory disease with or without endometriosis. Outcomes on 311 laparoscopically treated women.

J Gynecol Obstet Hum Reprod 2020 May 17:101811. Epub 2020 May 17.

Department of Obstetrics & Gynecology, Gynecologic Oncology and Minimally Invasive Pelvic Surgery, IRCCS Sacro Cuore Don Calabria Hospital - Negrar (Verona), Italy, International School of Surgical Anatomy, Italy.

Objective: to study possible associations between endometriosis and pelvic inflammatory disease (PID).

Design: Retrospective cohort analysis over 14 consecutive years, based on medical records and insurance coding in a tertiary care endometriosis reference center.

Setting: Tertiary care reference center for endometriosis. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101811DOI Listing

Effects of gene polymorphism and serum levels of IL-2 and IL-6 on endometriosis.

Eur Rev Med Pharmacol Sci 2020 May;24(9):4635-4641

Department of Gynecology, Ningbo No. 6 Hospital, Ningbo, China.

Objective: EMT is closely related to gene polymorphism and the expression level of immune-related substances in patients. Therefore, the aim of this study was to investigate the relationship between single nucleotide polymorphism (SNP), as well as serum levels of interleukin 2 (IL-2) and interleukin 6 (IL-6) in patients with endometriosis (EMT) and disease susceptibility.

Patients And Methods: Peripheral blood of EMT patients and healthy people were collected, respectively. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21148DOI Listing

Vitamin D status in endometriosis: a systematic review and meta-analysis.

Arch Gynecol Obstet 2020 May 19. Epub 2020 May 19.

Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Purpose: No consensus exists on the relationship between vitamin D status and endometriosis. The chief aim of our study was to evaluate the association between serum vitamin D levels and endometriosis.

Methods: We searched for MEDLINE, EMBASE, and China National Knowledge Infrastructure (CNKI) databases for studies elucidated the circulating vitamin D levels in endometriosis. Read More

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http://dx.doi.org/10.1007/s00404-020-05576-5DOI Listing

PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis.

Reprod Sci 2020 May 19. Epub 2020 May 19.

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

In cases of extragenital endometriosis or microscopic endometriosis lesions, pathological diagnosis can be challenging because endometriotic stroma and glands represent only a minor component of fibrotic endometriotic lesions. For better accuracy of diagnosis, the development of a sensitive and specific epithelial marker is beneficial. Previous studies showed that PAX8 is a highly sensitive and specific marker for primary and metastatic Mullerian epithelial tumors. Read More

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http://dx.doi.org/10.1007/s43032-020-00186-7DOI Listing

Establishment and Characterization of a Stromal Cell Line Derived From a Patient With Thoracic Endometriosis.

Reprod Sci 2020 May 19. Epub 2020 May 19.

Service d'Anatomie Pathologique, Institut Mutualiste Montsouris, Paris, France.

Thoracic endometriosis (TE) syndrome is a clinical condition known as an extrapelvic form of endometriosis with the presence of functioning endometrial tissue involving lung parenchyma, pleura, chest wall, or diaphragm. In an effort to obtain an endometriosis ex vivo model, we established the spontaneously growing TH-EM1 cell line from endometriotic implants in lung parenchyma from a woman with TE. Maintained in long-term culture, the cells grew as large mesenchymal-like cells with a doubling time between 5 and 6 days. Read More

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http://dx.doi.org/10.1007/s43032-020-00193-8DOI Listing

Deregulation of Stemness-Related Genes in Endometriotic Mesenchymal Stem Cells: Further Evidence for Self-Renewal/Differentiation Imbalance.

Iran Biomed J 2020 Apr 18. Epub 2020 Apr 18.

Endometriosis Research Center, Iran University of Medical Science, Tehran, Iran.

Background: Any irregularities in self-renewal/differentiation balance in endometriotic MSCs can change their fate and function, resulting in endometriosis development. This study aimed to evaluate the expression of OCT4 transcripts (OCT4A, OCT4B, and OCT4B1), SOX2, and NANOG in endometriotic MSCs to show their aberrant expression and to support self-renewal/differentiation imbalance in these cells.

Methods: MSCs were isolated from three endometriotic and three normal endometrium samples and characterized and analyzed for the expressions of OCT4A, OCT4B, OCT4B1, SOX2, and NANOG using the qRT-PCR. Read More

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http://dx.doi.org/10.29252/ibj.24.5.328DOI Listing

Peritoneal Fluid Cytokines Reveal New Insights of Endometriosis Subphenotypes.

Int J Mol Sci 2020 May 15;21(10). Epub 2020 May 15.

Translational 'Omics and Biomarkers group, KK Research Centre, KK Women's and Children's Hospital, Singapore 229899, Singapore.

Endometriosis is a common inflammatory gynecological disorder which causes pelvic scarring, pain, and infertility, characterized by the implantation of endometrial-like lesions outside the uterus. The peritoneum, ovaries, and deep soft tissues are the commonly involved sites, and endometriotic lesions can be classified into three subphenotypes: superficial peritoneal endometriosis (PE), ovarian endometrioma (OE), and deep infiltrating endometriosis (DIE). In 132 women diagnosed laparoscopically with and without endometriosis ( = 73, 59 respectively), and stratified into PE, OE, and DIE, peritoneal fluids (PF) were characterized for 48 cytokines by using multiplex immunoassays. Read More

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http://dx.doi.org/10.3390/ijms21103515DOI Listing

Relation between educational reliability and viewer interest in YouTube® videos depicting endometrioma cystectomy surgical techniques.

J Gynecol Obstet Hum Reprod 2020 May 16:101808. Epub 2020 May 16.

Private Obstetrics and Gynecology Clinic, Istanbul, Turkey.

Objective: To assess the reliability of YouTube® endometrioma cystectomy videos based on technical video analysis and considering the surgical steps.

Material And Method: The present study yielded 756 videos after a search on YouTube® with the keywords ''endometriosis cystectomy, endometrioma cystectomy, chocolate cyst cystectomy, and endometrioma surgery'' during the period from January 7, 2007 to January 7, 2019. The viewer interest parameters such as total number of subscribers, views, likes, dislikes, comments, source of the videos, and the date of upload were assessed. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101808DOI Listing

Dienogest And The Risk Of Endometriosis Recurrence Following Surgery: A Systematic Review And Meta-Analysis.

J Minim Invasive Gynecol 2020 May 16. Epub 2020 May 16.

Mount Sinai Hospital, Department of Obstetrics and Gynecology, 600 University Avenue, Toronto ON, Canada, M5G 1 × 5. Electronic address:

Study Objective: To determine whether dienogest therapy following endometriosis surgery reduces the risk of endometriosis recurrence compared to expectant management.

Data Sources: Ovid MEDLINE, Ovid EMBASE, PubMed, Cochrane Central Register of Controlled Trials, Web of Science, LILACS, clinicaltrials.gov and International Standard Randomized Controlled Trial Number Registry were searched from inception to March 2019 for observational and randomized controlled trials. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.05.007DOI Listing

Assessing CT imaging features combined with CEA and CA125 levels to identify endometriosis-associated ovarian cancer.

Abdom Radiol (NY) 2020 May 18. Epub 2020 May 18.

Department of Radiology, The First people's Hospital of Neijiang, No. 31 Jiaotong Road, Neijiang, China.

Purpose: To improve the diagnosis and identification of ovarian clear cell carcinoma (CCC) and ovarian endometrioid carcinoma (EC), we evaluated CT imaging findings and cut-off values for CEA and CA125.

Methods: The CT features and tumour markers (tumour size, location, morphology, composition, number of cysts, growth pattern of the mural nodules, mural nodule HWR, enhancement of the mural nodules, ascites, complications, CEA level, CA125 level) of 55 tumours in 52 patients with CCC, confirmed by surgery and pathology at the Yunnan Cancer Hospital from January 1, 2012 to December 30, 2018, were compared with those of 41 tumours in 36 patients with EC. All patients had a long history of endometriosis. Read More

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http://dx.doi.org/10.1007/s00261-020-02571-xDOI Listing

The Genetics of Endometriosis.

Twin Res Hum Genet 2020 May 19:1-2. Epub 2020 May 19.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.

Mapping genetic risk factors for endometriosis continues from early studies on women's health initiated by Nick Martin and Susan Treloar. Their initial recruitment of endometriosis cases and family members received a major boost and became a flagship project within the Cooperative Research Centre (CRC) for the Discovery of Common Human Disease. We extended the study through a formal collaboration with Professor Stephen Kennedy and his group in Oxford. Read More

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http://dx.doi.org/10.1017/thg.2020.36DOI Listing

Double-label immunohistochemistry to assess labyrinth structure of the mouse placenta with stereology.

Placenta 2020 May 31;94:44-47. Epub 2020 Mar 31.

Centre for Trophoblast Research, Department of Physiology, Development & Neuroscience, University of Cambridge, Cambridge, UK. Electronic address:

In mice, the labyrinth zone of the placenta exchanges nutrients and gases between mother and fetus. This placental zone is complex in structure and defects in its morphogenesis can compromise substrate exchange and thus, fetal growth and viability. Numerous mouse models involving genetic and environmental manipulation show abnormalities in labyrinth zone size. Read More

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http://dx.doi.org/10.1016/j.placenta.2020.03.014DOI Listing

[Autoimmune markers for non-invasive diagnosis of endometriosis in women].

Biomed Khim 2020 Feb;66(2):162-166

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia.

Endometriosis is a common estrogen-dependent chronic disease in women of reproductive age; it is associated with dysregulation of the immune response, local inflammation, and increased formation of autoantibodies. The aim of the study was to investigate the profile of autoantibodies in women with endometriosis and to evaluate their diagnostic value using new modifications of enzyme immunoassay. In women with endometriosis of stage III-IV (n=39), a wide spectrum of autoantibodies was detected, mainly of class G, including antibodies to endometrial antigens (tropomyosin 3, tropomodulin 3), the enzyme α-enolase, steroid (estradiol, progesterone) and gonadotropic hormones. Read More

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http://dx.doi.org/10.18097/PBMC20206602162DOI Listing
February 2020

Myeloid-derived suppressor cells in obstetrical and gynecological diseases.

Am J Reprod Immunol 2020 May 17:e13266. Epub 2020 May 17.

Insitute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, 200080, People's Republic of China.

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid-origin cells which have immunosuppressive activities in several conditions, such as cancer and inflammation. Recent research has also associated MDSCs with numerous obstetrical and gynecological diseases. During pregnancy, MDSCs accumulate to ensure maternal-fetal immune tolerance, whereas they are decreased in patients who suffer from early miscarriage or preeclampsia. Read More

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http://dx.doi.org/10.1111/aji.13266DOI Listing

Estrogen receptor-α immunoreactivity predicts symptom severity and pain recurrence in deep endometriosis.

Fertil Steril 2020 May 13. Epub 2020 May 13.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA.

Objective: To determine the relationship between steroid receptor expression and pain symptoms in endometriosis.

Design: Cross-sectional SETTING: University Hospital PATIENT(S): Women with endometriosis (N = 92).

Intervention(s): Tissue samples were obtained from patients with surgically diagnosed endometriosis. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2020.01.036DOI Listing

Endometriosis-associated epithelial ovarian cancer: Primary synchronous different cellular type on each ovary.

Taiwan J Obstet Gynecol 2020 May;59(3):460-463

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Female Cancer Foundation, Taipei, Taiwan. Electronic address:

Objective: Endometriosis-associated epithelial ovarian cancer (EOC) is a specific category of EOC, containing either endometrioid or clear cell carcinoma subtype. The characteristic of endometriosis-associated EOC includes an early stage at the diagnosis, presence of single histology type, and better prognosis. The synchronous two subtypes of endometriosis-associated EOC and presentation of far-advanced stage status at the initial diagnosis is rarely reported. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.03.024DOI Listing

Risk factors associated with epithelial ovarian cancer in women with endometriosis.

Taiwan J Obstet Gynecol 2020 May;59(3):353-355

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.tjog.2020.03.002DOI Listing

Negative sliding sign during dynamic ultrasonography predicts low endometriosis fertility index at laparoscopy.

J Minim Invasive Gynecol 2020 May 13. Epub 2020 May 13.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology, University of British Columbia, Vancouver, Canada. Electronic address:

Study Objectives: Endometriosis fertility index (EFI) is a robust tool to predict pregnancy rate in endometriosis patients who are attempting non-in vitro fertilization conception. However, EFI calculation requires laparoscopy. Newly established imaging techniques such as sliding sign, that is used to diagnose Pouch of Douglas obliteration, could provide a promising alternative. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.05.003DOI Listing

Raisonnement clinique.

J Obstet Gynaecol Can 2020 May;42(5):542

BC Women's Centre for Pelvic Pain and Endometriosis, Vancouver, C.-B.; University of British Columbia, Vancouver, C.-B.

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http://dx.doi.org/10.1016/j.jogc.2020.03.003DOI Listing

Clinical Conundrums.

J Obstet Gynaecol Can 2020 May;42(5):541

BC Women's Centre for Pelvic Pain and Endometriosis, Vancouver, BC; University of British Columbia, Vancouver, BC.

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http://dx.doi.org/10.1016/j.jogc.2020.02.009DOI Listing

Coexistence of endometriosis in women with mature cystic ovarian teratoma may not be rare.

Authors:
Heesuk Chae

J Gynecol Obstet Hum Reprod 2020 May 12:101786. Epub 2020 May 12.

Department of Obstetrics and Gynecology, Research Institute of Clinical Medicine, Chonbuk National University Hospital, Jeonju, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jogoh.2020.101786DOI Listing

Phagocyte function of peripheral neutrophil granulocytes and monocytes in endometriosis before and after surgery.

J Gynecol Obstet Hum Reprod 2020 May 12:101796. Epub 2020 May 12.

Department of Obstetrics and Gynecology, Univesity of Debrecen, Faculty of Medicine, 98. Nagyerdei krt., Debrecen 4012, Hungary. Electronic address:

Introduction: Endometriosis is a chronic systemic disease, which influence negatively the quality of life of affected women and responsible for infertility and chronic pelvic pain. Pathophysiology of the disease is still enigmatic, but insufficient immune surveillance may play a role in it. Peripheral natural immune cell function is rarely examined. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101796DOI Listing

Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure.

Hum Reprod Update 2020 May 15. Epub 2020 May 15.

Division of Obstetrics and Gynecology, Department of Biomedical, Experimental and Clinical Sciences, Careggi University Hospital University of Florence, Florence, Italy.

Background: Despite intense research, it remains intriguing why hormonal therapies in general and progestins in particular sometimes fail in endometriosis.

Objective And Rationale: We review here the action mechanisms of progesterone receptor ligands in endometriosis, identify critical differences between the effects of progestins on normal endometrium and endometriosis and envisage pathways to escape drug resistance and improve the therapeutic response of endometriotic lesions to such treatments.

Search Methods: We performed a systematic Pubmed search covering articles published since 1958 about the use of progestins, estro-progestins and selective progesterone receptor modulators, to treat endometriosis and its related symptoms. Read More

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http://dx.doi.org/10.1093/humupd/dmaa009DOI Listing

One-Size-Fits-All Approach Does Not Work for Gynecology Trainees Learning Endometriosis Ultrasound Skills.

J Ultrasound Med 2020 May 15. Epub 2020 May 15.

Acute Gynecology, Early Pregnancy, and Advanced Endosurgery Unit, Nepean Medical School, Nepean Hospital, University of Sydney, Kingswood, New South Wales, Australia.

Objectives: To evaluate whether gynecologic surgical trainees (fellows) can become competent in the real-time classification of the pouch of Douglas (POD) obliteration state and direct visualization of bowel deep endometriosis (DE) during a program with a prespecified number of transvaginal ultrasound (TVUS) examinations.

Methods: We performed a prospective study between December 2017 and December 2018. Three fellows (F1-F3) performed 50 scans each, which were all supervised by an expert sonologist, who performed the reference standard TVUS examination. Read More

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http://dx.doi.org/10.1002/jum.15337DOI Listing

Di-(2-ethylhexyl) Phthalate (DEHP) and Uterine Histological Characteristics.

Authors:
Yong-Pil Cheon

Dev Reprod 2020 Mar 31;24(1):1-17. Epub 2020 Mar 31.

Division of Developmental Biology and Physiology, Dept. of Biotechnology, Sungshin University, Seoul 02844, Korea.

Phthalates have a long industrial history. It is suspected that phthalates and their metabolites have detrimental effects on reproduction and development. They are well-known for their anti-androgenic effects. Read More

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http://dx.doi.org/10.12717/DR.2020.24.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201063PMC

A case of thoracic endometriosis-related pneumothorax in a menopausal woman.

Gen Thorac Cardiovasc Surg 2020 May 14. Epub 2020 May 14.

Center of Chest Medicine and Surgery, Ehime University, Toon, Ehime, Japan.

Thoracic endometriosis-related pneumothorax (TERP) or thoracic endometriosis syndrome (TES) usually occurs in women of childbearing age and affects the right thorax. Menopausal and left-sided cases are rare. A case of left-sided TERP in a postmenopausal woman after adjuvant endocrine therapy for breast cancer is reported. Read More

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http://dx.doi.org/10.1007/s11748-020-01381-8DOI Listing

Endometriosis: What is the Influence of Immune Cells?

Immunol Invest 2020 May 15:1-17. Epub 2020 May 15.

Research Institute of Oncology (Ipon)/Department of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil.

: Endometriosis does not have a well-established physiopathology. It has been addressed that endometriosis is an inflammatory disease, where endocrine-immunological interactions are probably involved in the pathogenesis of the disease. The role of the immune system in endometriosis has been suggested to play an important role in both initiation and progression of the disease. Read More

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http://dx.doi.org/10.1080/08820139.2020.1764577DOI Listing

COVID-19 and laparoscopic surgery, a scoping review of current literature and local expertise.

JMIR Public Health Surveill 2020 May 13. Epub 2020 May 13.

Amsterdam UMC, Vrije Universiteit Amsterdam, department of Gynecology and Obstetrics, Research Institute Reproduction and development, Amsterdam, NL.

Background: The current COVID19 pandemic is holding the world in its grip. Epidemiologist has shown that the mortality risks are higher when the health care system falls under the COVID19 pressure. It is, therefore, of great importance to keep health care providers (HCP) healthy and prevent contamination. Read More

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http://dx.doi.org/10.2196/18928DOI Listing

Endometriosis and Endometriosis-Associated Ovarian Cancer (EAOC).

Adv Exp Med Biol 2020 ;1242:73-87

Department of Minimally Invasive Gynecologic Surgery, NYU-Winthrop University Hospital, Mineola, NY, USA.

Endometriosis is a gynecologic disease that affects over 10% of women of reproductive age causing pelvic pain, dysmenorrhea, and infertility, resulting in significant disability and reduced quality of life. Very recent genetic studies have suggested that endometriosis is a clonal disease in the epithelium and its development is independent of stroma, providing new insight into the genesis of endometriosis. The endometrioid tissue lining may also react by epithelial atypical hyperplasia and even neoplasia, in a manner somehow similar to that in the uterine cavity and under the same hormonal influences. Read More

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http://dx.doi.org/10.1007/978-3-030-38474-6_5DOI Listing
January 2020