26,159 results match your criteria Endometriosis


[Correlation between polymorphism of CYP19A1, GSTM1, GSTT1 and GSTP1 gene and endometriosis].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):515-519

Reproductive Medicine Center, the Affiliated Hospital of Inner Mongolia Medical University, Huhehot 010050, China.

To study the association between polymorphisms in CYP19A1 rs2899470, GSTM1, GSTT1, and GSTP1 rs1695 and the development of endometriosis. Between October 2015 and October 2017, 262 endometriosis patients and 275 control subjects were recruited from the Affiliated Hospital of Inner Mongolia Medical University. Genotyping was conducted using polymerase chain reaction-coupled with restriction fragment length polymorphism and multiplex allele specific polymerase chain reaction. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.008DOI Listing
February 2019

HLA-G is upregulated in advanced endometriosis.

Eur J Obstet Gynecol Reprod Biol 2019 Feb 6;235:36-41. Epub 2019 Feb 6.

Endometriosis Section, Gynecologic Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Gynecologic Division, BP - A Beneficencia Portuguesa de Sao Paulo, Sao Paulo, SP, Brazil. Electronic address:

Objective: To assess whether the HLA-G immunomodulatory protein is potentially involved in the pathophysiology of endometriosis or disease progression.

Study Design: Cross-sectional observational study of 227 women who underwent laparoscopy, being 146 for endometriosis excision and 81 for elective tubal ligation (control group). Soluble HLA-G (sHLA-G) levels in the serum and peritoneal fluid (PF), as well as the HLA-G protein expression in matched eutopic and ectopic endometrium of women with and without endometriosis were evaluated by ELISA and immunohistochemistry assays, respectively. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.030DOI Listing
February 2019

Epidemiologic Factors Associated with Endometriosis in East Asia.

Gynecol Minim Invasive Ther 2019 Jan-Mar;8(1):4-11. Epub 2019 Jan 23.

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou, Taiwan.

Aim: With a perplexing pathogenesis and an incidence rate of approximately 10% among women of reproductive age, endometriosis affects more women in Asia than in any other continent in the world. This paper reviews the available data on the epidemiology and risk factors associated with endometriosis in East Asia.

Methods: Included studies were published between January 2000 and December 2016. Read More

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http://dx.doi.org/10.4103/GMIT.GMIT_83_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367920PMC
January 2019

Preoperative rectosigmoid endoscopic ultrasonography predicts the need for bowel resection in endometriosis.

World J Gastroenterol 2019 Feb;25(6):696-706

Department of Hepato-gastro-enterology, Centre Hospitalier Intercommunal Poissy Saint Germain, Poissy 78300, France.

Background: Rectosigmoid endometriosis is an underdiagnosed disease responsible for abdominal pain, transit disorders and rectal bleeding. Two surgical approaches, rectosigmoid bowel resection (segmental or patch) or intramuscular layer dissection (shaving), are available.

Aim: To assess whether the lesion features observed preoperative rectosigmoid endoscopic ultrasonography (RS-EUS) might predict the need for bowel resection. Read More

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http://dx.doi.org/10.3748/wjg.v25.i6.696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378538PMC
February 2019

Does endometriosis affect professional life? A matched case-control study in Switzerland, Germany and Austria.

BMJ Open 2019 Jan 9;9(1):e019570. Epub 2019 Jan 9.

Department of Reproductive Endocrinology, University Hospital Zurich, Zurich, Switzerland.

Objectives: Endometriosis is a gynaecological disease most commonly causing severe and chronic pelvic pain as well as an impaired quality of life. The aim of this study was to investigate if and how endometriosis affects choices regarding professional life as well as the quality of daily working life.

Design, Setting And Participants: In the context of a multicentre case-control study, we collected data from 505 women with surgically/histologically confirmed diagnosis of endometriosis and 505 matched controls. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-019570DOI Listing
January 2019

[Rectovaginal fistula prevention after enbloc colorectal resection and hysterectomy for deep endometriosis].

Gynecol Obstet Fertil Senol 2019 Feb 16. Epub 2019 Feb 16.

Department of Gynecology and Obstetrics, Tenon University Hospital, Assistance publique-des Hôpitaux de Paris (AP-HP), Sorbonne University, 75000 Paris, France; Groupe de recherche clinique 6 (GRC6-UPMC), centre expert en endométriose (C3E), 75020 Paris, France; UMR_S938 Sorbonne University, 75000 Paris, France.

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http://dx.doi.org/10.1016/j.gofs.2019.01.009DOI Listing
February 2019

Progesterone Receptor B ( PGR-B) Is Partially Methylated in Eutopic Endometrium From Infertile Women With Endometriosis.

Reprod Sci 2019 Feb 19:1933719119828078. Epub 2019 Feb 19.

1 Human Reproduction Division, Department of Obstetrics and Gynecology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.

Endometriosis is frequently related to infertility and little is known about the mechanisms underlying this association. Some studies point to an endometrial factor involved in this condition, which could compromise embryo implantation. Progesterone plays crucial role in endometrial receptivity by acting through progesterone receptor ( PGR) isoforms PR-A and PR-B whose expression is epigenetically regulated by DNA methylation, in a specific promoter region for each isoform. Read More

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http://dx.doi.org/10.1177/1933719119828078DOI Listing
February 2019

Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells.

Reprod Sci 2019 Feb 19:1933719119828112. Epub 2019 Feb 19.

1 Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.

Objects:: There is growing evidence that sphingosine 1-phosphate (S1P) is involved in inflammatory diseases. As endometriosis is known as an inflammatory disease, we investigated the role of S1P system in the development of endometriosis.

Methods:: The expression of sphingosine kinase (SphK) 1 in endometriosis lesions was examined by immunohistochemistry. Read More

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http://dx.doi.org/10.1177/1933719119828112DOI Listing
February 2019

"I feel like I'm being stabbed by a thousand tiny men": The challenges of communicating endometriosis pain.

Authors:
Stella Bullo

Health (London) 2019 Feb 19:1363459318817943. Epub 2019 Feb 19.

Manchester Metropolitan University, UK.

Endometriosis, as a widespread gynecological condition, affects an estimated 1 in 10 women and yet has a worldwide average diagnosis length of 7.5 years. Causing incapacitating pain, among other associated manifestations, the condition severely impacts on women's lives. Read More

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http://dx.doi.org/10.1177/1363459318817943DOI Listing
February 2019

Therapeutic Approaches of Resveratrol on Endometriosis via Anti-Inflammatory and Anti-Angiogenic Pathways.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov, 500019 Brasov, Romania.

Endometriosis represents a severe gynecological pathology, defined by implantation of endometrial glands and stroma outside the uterine cavity. This pathology affects almost 15% of women during reproductive age and has a wide range of consequences. In affected women, infertility has a 30% rate of prevalence and endometriosis implants increase the risk of ovarian cancer. Read More

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http://dx.doi.org/10.3390/molecules24040667DOI Listing
February 2019

Macrophage ERα promoted invasion of endometrial cancer cell by mTOR/KIF5B -mediated epithelial to mesenchymal transition.

Immunol Cell Biol 2019 Feb 18. Epub 2019 Feb 18.

Institute of Basic Medical Sciences and Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Tumor associated macrophages (TAMs) exert tumor-promoting effects. There have been reports that Estrogen receptors (ERs) are expressed on the infiltrating macrophages of endometriosis, ovarian cancer and lung cancer. However, the role of ERs in macrophages is not well characterized. Read More

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http://dx.doi.org/10.1111/imcb.12245DOI Listing
February 2019

The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls.

Sci Rep 2019 Feb 18;9(1):2204. Epub 2019 Feb 18.

Department of Obstetrics and Gynecology, Koc University Faculty of Medicine, Istanbul, Turkey.

Dysbiosis in the genital tract or gut microbiome can be associated with endometriosis. We sampled vaginal, cervical and gut microbiota from 14 women with histology proven stage 3/4 endometriosis and 14 healthy controls. The V3 and V4 regions of the 16S rRNA gene were amplified following the 16S Metagenomic Sequencing Library Preparation. Read More

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http://dx.doi.org/10.1038/s41598-019-39700-6DOI Listing
February 2019

Estimation of plasma levels of bisphenol-A & phthalates in fertile & infertile women by gas chromatography-mass spectrometry.

Indian J Med Res 2018 Dec;148(6):734-742

National Center for Preclinical Reproductive & Genetic Toxicology, ICMR-National Institute for Research in Reproductive Health, Mumbai, India.

Background & Objectives: Bisphenol-A (BPA) and phthalates are utilized widely in consumer products. Due to their ubiquitous presence in the environment, a concern is expressed worldwide about their possible effect on human reproductive health. This study was conducted to compare the internal exposure of BPA and phthalates (using their metabolites as biomarkers) in plasma samples of infertile and fertile women. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_2077_16DOI Listing
December 2018

The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial.

Gynecol Endocrinol 2019 Feb 19:1-8. Epub 2019 Feb 19.

a Department of Anatomy, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.

Endometriosis is an inflammatory disease; the hallmark of inflammation is over-activation of matrix metalloproteinases (MMPs). The regulatory effects of Resveratrol on MMPs were formerly depicted in other cell lines. This study aimed at investigating the effects of Resveratrol on expression of MMP-2 and -9 in endometriosis patients. Read More

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http://dx.doi.org/10.1080/09513590.2019.1576612DOI Listing
February 2019

Endometriosis-associated ovarian cancer: What have we learned so far?

Clin Chim Acta 2019 Feb 15. Epub 2019 Feb 15.

Division of Laboratory Medicine, Asia University Hospital, Asia University, Taichung, Taiwan; Deparment of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan; Deparment of Post-Baccalaureate Veterinary Medicine, Asia University, Taichung, Taiwan; Deparment of Nursing, Asia University, Taichung, Taiwan. Electronic address:

Endometriosis is defined as the presence of ectopic endometrial tissue outside of the uterine cavity, most commonly in the ovaries and peritoneum. It is a complex disease that is influenced by multiple factors. It is also a common gynecological disorder and affects approximately 10-15% of all women of reproductive age. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193006
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http://dx.doi.org/10.1016/j.cca.2019.02.016DOI Listing
February 2019
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Investigation of anti-mullerian hormone (AMH) level and ovarian response in infertile women with endometriosis in IVF cycles.

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):719-722

Department of Obstetrics and Gynecology, Infertility Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Endometriosis, can cause ovarian conflict and reduced ovarian reserve that could lead to lower response to assisted reproductive techniques.

Objective: Current study was conducted to determine the association between level of anti-mullerian hormone (AMH) and the infertility treatment outcomes in infertile females with endometriosis versus the non-endometriosis infertile subject.

Materials And Methods: In this case-control study, 64 infertile females who referred to Shariati Hospital from April 2015 to November 2017 were enrolled. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350853PMC
November 2018

Protein intake and the risk of premenstrual syndrome.

Public Health Nutr 2019 Feb 18:1-8. Epub 2019 Feb 18.

1Department of Biostatistics and Epidemiology,University of Massachusetts,715 North Pleasant Street,Arnold House 412,Amherst,MA01003,USA.

Objective: To examine the relationship between protein intake and the risk of incident premenstrual syndrome (PMS).

Design: Nested case-control study. FFQ were completed every 4 years during follow-up. Read More

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http://dx.doi.org/10.1017/S1368980018004019DOI Listing
February 2019
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A calcium-dependent phospholipase A2 (cPLA2) expression is regulated by MIG-6 during endometrial tumorigenesis.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, College of Human Medicine, Grand Rapids, MI, 49503, USA. Electronic address:

The ovarian steroid hormones, estrogen (E2) and progesterone (P4), are essential regulators of uterine biology. The imbalance of these ovarian steroid hormones leads to uterine diseases such as endometrial cancer, endometriosis, and infertility. Mitogen-inducible gene 6 (MIG-6) is an adaptor protein. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.034DOI Listing
February 2019

Lipoxin A Suppresses IL-1β-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPK Activation in Endometriosis.

Reprod Sci 2019 Feb 17:1933719119828115. Epub 2019 Feb 17.

1 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China.

Endometriosis is an inflammation-dependent gynecologic disorder. Increased cyclooxygenase-2 (COX-2) expression plays an important role in the development and progression of endometriosis. Lipoxin A (LXA) is an endogenous anti-inflammation lipid and showed inhibitory effects on the development of endometriosis; however, the mechanism remains unclear. Read More

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http://dx.doi.org/10.1177/1933719119828115DOI Listing
February 2019

[Clinical Assessment of Fourteen Cases of Thoracic Endometriosis].

Kyobu Geka 2019 Feb;72(2):87-91

Division of Thoracic Surgery,Tohoku Medical and Pharmaceutical University, Sendai, Japan.

We retrospectively assessed the clinical and pathological features of 14 patients with thoracic endometriosis who were treated at our hospital from 2007 to 2017. Thirteen patients presented pneumothorax and 1 patient presented bloody sputum. All were treated surgically. Read More

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February 2019

Macrophages infiltrating endometriosis-like lesions exhibit progressive phenotype changes in a heterologous mouse model.

J Reprod Immunol 2019 Jan 25;132:1-8. Epub 2019 Jan 25.

Robinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, SA 5000, Australia; The Women's and Children's Hospital, Department of Obstetrics and Gynaecology, North Adelaide, SA 5006, Australia. Electronic address:

Endometriotic lesion development involves complex interactions between endometrial tissue, the peritoneum and immune cells. Macrophages are essential in this process; however their precise roles are not defined. To investigate whether infiltrating macrophages acquire functionally different phenotypes during lesion development, human endometrial tissues were grafted into immunodeficient mice expressing macrophage-specific green fluorescent protein (GFP). Read More

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http://dx.doi.org/10.1016/j.jri.2019.01.002DOI Listing
January 2019

Pro-endometriotic niche in endometriosis.

Reprod Biomed Online 2018 Dec 23. Epub 2018 Dec 23.

Department of Obstetrics and Gynaecology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address:

Endometriosis is a complex and heterogeneous disorder of unknown aetiology. This benign disease possesses special biological behaviours that mimic those of malignant tumours. A pro-endometriotic niche established by an existing lesion is a supportive micro-environment for the progression of endometriosis. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.12.025DOI Listing
December 2018

The risk of extra-ovarian malignancies among women with endometriosis: A systematic literature review and meta-analysis.

Crit Rev Oncol Hematol 2019 Feb 9;134:72-81. Epub 2019 Jan 9.

Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy. Electronic address:

We conducted a meta-analysis of studies reporting on the risk of extra-ovarian malignancies among women with endometriosis. Summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We explored causes of between-studies heterogeneity and assessed the presence of publication bias. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2018.12.009DOI Listing
February 2019
2 Reads

Catamenial Haemothorax - A Rare Case Of Thoracic Endometriosis.

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Thoracic Surgery, Royal Brompton Hospital.

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http://dx.doi.org/10.1016/j.athoracsur.2018.12.062DOI Listing
February 2019

Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes.

Mol Hum Reprod 2019 Feb 16. Epub 2019 Feb 16.

Department of Obstetrics and Gynaecology and Gynaecology Research Centre, Royal Women's Hospital, University of Melbourne, Parkville, Victoria, Australia.

Endometriotic lesions are composed in part of endometrial-like stromal cells, however, there is a shortage of immortalized human endometrial stromal cultures available for research. As genetic factors play a role in endometriosis risk, it is important that genotype is also incorporated into analysis of pathological mechanisms. Human telomerase reverse transcriptase (hTERT) immortalization (using Lenti-hTERT-green fluorescent protein virus) took place following genotype selection; 13 patients homozygous for either the risk or non-risk 'other' allele for one or more important endometriosis risk single nucleotide polymorphism on chromosome 1p36. Read More

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http://dx.doi.org/10.1093/molehr/gaz006DOI Listing
February 2019
1 Read

Imaging of postoperative endometriosis.

Diagn Interv Imaging 2019 Feb 12. Epub 2019 Feb 12.

Department of Radiology, Hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.

Endometriosis is a chronic gynecological condition that affects primarily young women. Imaging plays a pivotal role for the diagnosis and pre-surgical mapping of the disease. By comparison, the role of imaging in the identification of disease recurrence and postoperative complications are not well established. Read More

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http://dx.doi.org/10.1016/j.diii.2018.11.003DOI Listing
February 2019

Clear Cell Carcinoma of the Abdominal Wall as a Rare Complication of General Obstetric and Gynecologic Surgeries: 15 Years of Experience at a Large Academic Institution.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Department of Obstetrics and Gynecology; National Taiwan University Hospital, Taipei 100, Taiwan.

The objective of this article was to report the clinicopathological characteristics, treatment modalities, and outcomes of patients with clear cell carcinoma (CCC) of the abdominal wall. Medical records of six patients diagnosed with CCC of the abdominal wall between May 2003 and May 2018 at the National Taiwan University Hospital were reviewed. All patients had prior obstetric or gynecologic surgeries. Read More

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http://dx.doi.org/10.3390/ijerph16040552DOI Listing
February 2019
1 Read

Novel Role of Dehydrated Human Amnion/Chorion Membrane in Healing of Denuded Ureter in Robot-Assisted Excision of Endometriosis.

Case Rep Obstet Gynecol 2019 15;2019:1920430. Epub 2019 Jan 15.

Advanced Urology Associates, 1541 Riverboat Center Drive, Joliet, IL 60431, USA.

Ureteral injury is an uncommon but potentially morbid complication following any open or endoscopic pelvic procedure. Gynecologic surgeries alone make up 50 percent of nonurologic ureteral injuries leading to prolonged hospital stays, secondary interventions, and potential loss of renal function. The use of AmnioFix ® a processed dehydrated, immunologically privileged cellular amniotic membrane allograft has been well established in urologic and gynecologic procedures. Read More

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http://dx.doi.org/10.1155/2019/1920430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350570PMC
January 2019
1 Read

The prevalence of self-reported diagnosed endometriosis in the Australian population: results from a nationally-representative survey.

BMC Res Notes 2019 Feb 14;12(1):88. Epub 2019 Feb 14.

Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia.

Objective: Currently, it is estimated that one in 10 women of reproductive age are affected by the reproductive condition known as endometriosis. However, there has been limited research and policy attention on the prevalence of endometriosis in Australia. Utilising a nationally-representative Australian sample (N = 2025), this study aimed to report on the prevalence of endometriosis in the general population and to examine the sociodemographic factors associated with the condition. Read More

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http://dx.doi.org/10.1186/s13104-019-4114-6DOI Listing
February 2019

PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis.

Reprod Sci 2019 Feb 14:1933719119828095. Epub 2019 Feb 14.

1 Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan.

In cases of extragenital endometriosis or microscopic endometriosis lesions, pathological diagnosis can be challenging because endometriotic stroma and glands represent only a minor component of fibrotic endometriotic lesions. For better accuracy of diagnosis, the development of a sensitive and specific epithelial marker is beneficial. Previous studies showed that PAX8 is a highly sensitive and specific marker for primary and metastatic Mullerian epithelial tumors. Read More

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http://dx.doi.org/10.1177/1933719119828095DOI Listing
February 2019
1 Read

Perioperative Intervention by β-Blockade and NF-κB Suppression Reduces the Recurrence Risk of Endometriosis in Mice Due to Incomplete Excision.

Reprod Sci 2019 Feb 14:1933719119828066. Epub 2019 Feb 14.

1 Shanghai OB/GYN Hospital, Fudan University, Shanghai, China.

Despite the demonstrated efficacy of surgical treatment of endometriosis, recurrence after surgery still remains a formidable challenge. Surgery, especially when performed repeatedly, decreases ovarian reserve. Clearly, control of recurrence is an unmet medical need. Read More

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http://dx.doi.org/10.1177/1933719119828066DOI Listing
February 2019

A comprehensive review of hormonal and biological therapies for endometriosis: latest developments.

Expert Opin Biol Ther 2019 Feb 14. Epub 2019 Feb 14.

a Academic Unit of Obstetrics and Gynecology , Ospedale Policlinico San Martino , Largo R. Benzi 10, 16132 Genoa , Italy.

Introduction: Endometriosis is a chronic benign estrogen dependent disease characterized by the presence of endometriotic glands and stroma outside the uterine cavity. Although combined hormonal contraceptives and progestins, currently available first-line treatments for endometriosis, are efficacious and well tolerated for treating disease-related pain, some women experience partial or no improvement of pain or its recurrence is frequent after discontinuation of the therapies. For these reasons, new drugs are under investigation for the treatment of endometriosis. Read More

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http://dx.doi.org/10.1080/14712598.2019.1581761DOI Listing
February 2019
1 Read

[An interdisciplinary approach to the management of bladder endometriosis].

Urologiia 2018 Oct(4):118-121

Ya.L. Tsivyan Novosibirsk Scientific Research Institute of Traumatology and Orthopedics of Minzdrav of Russia, Novosibirsk, Russia.

Urinary endometriosis a rare condition accounting for 1-5.5% of all of the extragenital endometriosis locations. Bladder endometriosis is the most common form of urinary endometriosis, comprising 85% of cases. Read More

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October 2018
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MiR-210-3p protects endometriotic cells from oxidative stress-induced cell cycle arrest by targeting BARD1.

Cell Death Dis 2019 Feb 13;10(2):144. Epub 2019 Feb 13.

Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3 Qingchun East Road, Jianggan District, 310016, Hangzhou, China.

Endometriosis is associated with benign but adversely developed cysts in the extrauterine environment. The oxidative imbalanced environment induces DNA damage and affects cell cycle progression of endometrial stromal cells (ESCs) and endometrial epithelial cells, but how endometriotic cells maintain proliferation in the presence of oxidative stress is not clear. Growing evidence has indicated that the ectopic hypoxic microenvironment and oxidative stress can stimulate the growth of endometriotic cells, which is mainly due to the increase of HIF-1α. Read More

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http://dx.doi.org/10.1038/s41419-019-1395-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374490PMC
February 2019
1 Read

Genomic evidence of Y chromosome microchimerism in the endometrium during endometriosis and in cases of infertility.

Reprod Biol Endocrinol 2019 Feb 13;17(1):22. Epub 2019 Feb 13.

Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.

Background: Previous studies, which were primarily based on the fluorescent in-situ hybridisation (FISH) technique, revealed conflicting evidence regarding male foetal microchimerism in endometriosis. FISH is a relatively less sensitive technique, as it is performed on a small portion of the sample. Additionally, the probes used in the previous studies specifically detected centromeric and telomeric regions of Y chromosome, which are gene-sparse heterochromatised regions. Read More

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http://dx.doi.org/10.1186/s12958-019-0465-zDOI Listing
February 2019
1 Read

Methotrexate infusion followed by uterine artery embolisation for the management of placental adhesive disorders: a case series.

Clin Radiol 2019 Feb 9. Epub 2019 Feb 9.

Department of Clinical Pharmacy, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Aim: To evaluate the efficacy and safety of the uterine artery embolisation (UAE) in combination with methotrexate (MTX) for conservative management of placental adhesive disorders.

Material And Methods: Patients with placental adhesive disorders (including accreta, increta, and percreta lesions) that were treated with UAE in combination with MTX were identified and were followed prospectively for outcomes including uterine preservation and complications.

Results: Twenty-six patients were identified who had the diagnosis of abnormal placenta implantation during this study. Read More

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http://dx.doi.org/10.1016/j.crad.2019.01.006DOI Listing
February 2019
1 Read

Risk of miscarriage in women with endometriosis undergoing IVF fresh cycles: a retrospective cohort study.

Reprod Biol Endocrinol 2019 Feb 12;17(1):21. Epub 2019 Feb 12.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Haidian district, North garden road, No 49, Beijing, People's Republic of China.

Background: Endometriosis is thought to affect the effectiveness of ART by an increased risk of miscarriage. We aimed to investigate the impact of endometriosis in women achieving singleton pregnancies through IVF fresh cycles and risk of miscarriage.

Methods: This retrospective cohort study included all women undergoing a first IVF cycle and achieving singleton pregnancies after fresh embryo transfer in a tertiary university hospital reproductive medical center between January 2008 and June 2016. Read More

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http://dx.doi.org/10.1186/s12958-019-0463-1DOI Listing
February 2019

Galectin-3 plays an important role in endometriosis development and is a target to endometriosis treatment.

Mol Cell Endocrinol 2019 Feb 9. Epub 2019 Feb 9.

Morphological Sciences Program, Biomedical Sciences Institute, Federal University of Rio de Janeiro - UFRJ, Rio de Janeiro, RJ, Brazil.

This study aimed to analyze galectin-3 importance in endometriotic lesions development and the effect of recombinant Gal-3 carbohydrate recognition domain (Gal3C) in experimental endometriosis treatment. Experimental endometriosis was induced in WT and Gal-3-/- mice. Initially developed lesions were macroscopically and histologically analyzed, including immunohistochemical analysis. Read More

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http://dx.doi.org/10.1016/j.mce.2019.02.007DOI Listing
February 2019
1 Read

The Association between hysterectomy and ovarian cancer risk: A population-based record-linkage study.

J Natl Cancer Inst 2019 Feb 11. Epub 2019 Feb 11.

Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Background: Recent studies have called into question the long-held belief that hysterectomy without oophorectomy protects against ovarian cancer. This population-based longitudinal record-linkage study aimed to explore this relationship, overall and by age at hysterectomy, time period, surgery type, and indication for hysterectomy.

Methods: We followed the female adult Western Australian population (837,942 women) across a 27-year period using linked electoral, hospital, births, deaths, and cancer records. Read More

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http://dx.doi.org/10.1093/jnci/djz015DOI Listing
February 2019
1 Read

Reduced α-2,6 sialylation regulates cell migration in endometriosis.

Hum Reprod 2019 Feb 12. Epub 2019 Feb 12.

Département 'Développement, Reproduction et Cancer', Institut Cochin, INSERM U1016 (Professeur Batteux), Université Paris Descartes, Sorbonne Paris Cité, 22 Rue Méchain, Paris, France.

Study Question: Is endometriosis associated with aberrant sialylation patterns and what is the potential impact of such anomalies on cell migratory properties?

Summary Answer: The reduced α-2,6 sialylation patterns in the peritoneal fluid of endometriosis-affected women and in stromal and epithelial cells from endometriotic lesions could be associated with enhanced cell migration.

What Is Known Already: Endometriosis is considered to be a benign disease although, like cancer, it has the characteristic of being an invasive disease with cells that have an enhanced capacity to migrate. Aberrant sialylation has been reported in various malignancies and it has been linked to tumour invasion and metastasis. Read More

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http://dx.doi.org/10.1093/humrep/dey391DOI Listing
February 2019
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Notch activity mediates oestrogen-induced stromal cell invasion in endometriosis.

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

W Xiong, Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wu Han, China.

Oestrogen has been reported to control the invasiveness of endometrial stromal cells in endometriosis. Notch signalling, a master regulator of cell invasion in tumours, is regulated by oestrogen in other diseases and hyperactivated in endometriotic stromal cells. Therefore, we hypothesized that an interaction between Notch signalling and oestrogen may exist in the regulation of endometrial stromal cell invasion, which is essential for the development of endometriosis. Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0326DOI Listing
February 2019
2 Reads
3.174 Impact Factor

Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids.

Sci Rep 2019 Feb 11;9(1):1779. Epub 2019 Feb 11.

Laboratory of Endometrium, Endometriosis & Reproductive Medicine, Department of Development and Regeneration, KU Leuven, Herestraat 49 box 611, 3000, Leuven, Belgium.

Successful pregnancy requires the establishment of a complex dialogue between the implanting embryo and the endometrium. Knowledge regarding molecular candidates involved in this early communication process is inadequate due to limited access to primary human endometrial epithelial cells (EEC). Since pseudo-pregnancy in rodents can be induced by mechanical scratching of an appropriately primed uterus, this study aimed to investigate the expression of mechanosensitive ion channels in EEC. Read More

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http://dx.doi.org/10.1038/s41598-018-38376-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370865PMC
February 2019
2 Reads

The impact of endometriosis on early embryo morphokinetics: a case-control study.

Syst Biol Reprod Med 2019 Feb 11:1-8. Epub 2019 Feb 11.

a Department of Reproductive Medicine , Bahceci Fulya IVF Centre , Istanbul , Turkey.

The aim of this study was to evaluate the possible effects of endometriosis on early embryo development, by comparing the morphokinetic development of embryos obtained from women with clinically confirmed endometriosis with the ones obtained from tubal factor infertility cases. A total of 82 cycles/patients including 53 cycles with endometriosis and 29 cycles with tubal factor infertility were evaluated. A total of 439 embryos were scored for embryo morphokinetics. Read More

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http://dx.doi.org/10.1080/19396368.2019.1573275DOI Listing
February 2019
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Genome-wide analysis of DNA methylation in endometriosis using Illumina Human Methylation 450 K BeadChips.

Mol Reprod Dev 2019 Feb 11. Epub 2019 Feb 11.

Department of Gynecology, Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei, China.

Endometriosis is a common chronic gynecologic disorder characterized by the presence and growth of endometrial-like tissue outside of the uterine cavity. Although the exact etiology remains unclear, epigenetic modifications, such as DNA methylation, are thought to contribute to the pathogenesis of endometriosis. Here, we used the Illumina Human Methylation 450 K BeadChip Array to analyze the genome-wide DNA methylation profiles of six endometriotic lesions and six eutopic endometria from patients with ovarian endometriosis and six endometria of women without endometriosis. Read More

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http://doi.wiley.com/10.1002/mrd.23127
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http://dx.doi.org/10.1002/mrd.23127DOI Listing
February 2019
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Seeing red: diet and endometriosis risk.

Ann Transl Med 2018 Dec;6(Suppl 2):S119

Department of Obstetrics & Gynecology, University of Michigan Health System, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.21037/atm.2018.12.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330594PMC
December 2018

Behind the Times: Revisiting Endometriosis and Race.

Am J Obstet Gynecol 2019 Feb 6. Epub 2019 Feb 6.

Ottawa Hospital Research Institute; University of Ottawa, Department of Obstetrics and Gynecology.

Endometriosis is a common gynecologic condition, affecting approximately 10% of reproductive aged women. It commonly presents with pelvic pain, painful periods, and infertility and can significantly impact one's quality of life. Early exploration into the pathophysiology of this condition identified race as a risk factor for endometriosis, with the condition predominantly identified in white women. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.238DOI Listing
February 2019
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Reply to: Adhesion proteins: suitable therapeutic targets or biomarkers of therapy response for endometriosis?

Acta Obstet Gynecol Scand 2019 Feb 8. Epub 2019 Feb 8.

Center for Reproductive Medicine, Taipei Medical University Hospital, Taiwan.

We are pleased to read the recent letter to editor by Barra and Ferrero who have been interested in our recent publication in AOGS. In that report, we demonstrated the decreased expression of Tensin 1 (TNS1) in tissue and serum of women with endometriosis after receiving gonadotropin-releasing-hormone agonist (GnRHa) treatment. In our study, we only recruited patients with ovarian endometriosis as mentioned in the material and methods section. Read More

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http://dx.doi.org/10.1111/aogs.13566DOI Listing
February 2019
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CYFRA 21-1 and Placental Growth Factor as Screening Markers for Endometriosis.

Med Sci Monit 2019 Feb 9;25:1087-1092. Epub 2019 Feb 9.

Department of Obstetrics and Gynecology, Hallym University Dongtan Sacred Heart Hospital, Kyeonggido, South Korea.

BACKGROUND This study evaluated the performance of serum CYFRA 21-1 and placental growth factor (PIGF) as screening markers for endometriosis. MATERIAL AND METHODS In this prospective study included 81 female patients who underwent laparoscopy to treat benign ovarian tumors. Serum samples were obtained from all study patients before surgery. Read More

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http://dx.doi.org/10.12659/MSM.912787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377587PMC
February 2019
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Endometriosis progression in tumor necrosis factor receptor p55-deficient mice: Impact on oxidative/nitrosative stress and metallomic profile.

J Trace Elem Med Biol 2019 Mar 30;52:157-165. Epub 2018 Dec 30.

Laboratorio de Biología de la Reproducción (LABIR), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis (IMIBIO-SL), CONICET, Ejército de Los Andes 950, CP D5700HHW, San Luis, Argentina. Electronic address:

The present study was conducted to investigate whether the deficiency of tumor necrosis factor receptor p55 (TNFRp55) modulates oxidative/nitrosative stress and metallomic profile into the peritoneal cavity during the experimental endometriosis progression in mice. Female C57BL/6 mice, wild-type (WT) and TNFRp55 knockout (KO) of two months were used. Endometriosis was induced experimentally by autotransplanting three pieces of the right uterine horn to the intestinal mesentery. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.013DOI Listing