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Wiad Lek 2022 ;75(5 pt 2):1234-1241

NATIONAL PIROGOV MEMORIAL MEDICAL UNIVERSITY, VINNYTSIA, UKRAINE.

Objective: The aim: To assess the current prevalence and identify the risk factors for infertility among couples of reproductive age in Ukraine.

Patients And Methods: Materials and methods: We conducted a retrospective multicentre cohort study was based on reproductive health surveillance data among married populations from January 1st, 2019 to December 31st, 2021 in Ukraine. Definitions of infertility were used from the WHO. Read More

Front Endocrinol (Lausanne) 2022 9;13:854345. Epub 2022 Jun 9.

Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China.

Background: Endometriosis (EMS) is a relapsing and estrogen-dependent disease. For endometriosis such as deep endometriosis and ovarian endometrioid cysts, surgery is the most effective treatment. Long-term follow-up showed that the recurrence rate of endometriosis after surgical treatment was high, so postoperative drugs were needed to reduce recurrence, and Gonadotropin-releasing hormone agonists (GnRH-a) were the most commonly used drug for postoperative management. Read More

Front Med (Lausanne) 2022 9;9:872481. Epub 2022 Jun 9.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: This study aimed to establish an effective prognostic nomogram for the postoperative recurrence of endometrioma or endometriosis-related pain for patients with endometrioma after long-term follow-up, who were younger than 45 years old and received postoperative therapy.

Methods: The predictive nomogram was based on 323 patients who underwent cystectomy for endometrioma at Perking Union Medical College Hospital from January 2009 to April 2013, and the last follow-up occurred in September 2018. We collected information on all included patients, including preoperative data, intraoperative data, and long-term follow-up data after surgery. Read More

Asian J Surg 2022 Jun 24. Epub 2022 Jun 24.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.

BMC Womens Health 2022 Jun 25;22(1):253. Epub 2022 Jun 25.

Ningbo Women&Children's Hospital, Ningbo, China.

Background: The diagnosis of endometriosis (EMs) is still based on laparoscopic observation. This study tries to verify whether exosomal tRNA-derived fragments (tRFs) in leucorrhea can be used as non-invasive diagnostic markers.

Methods: Endometrial tissues and leucorrhea were sampled from women hospitalized in Ningbo University Affiliated Hospital from January 2021 to July 2021 with (n = 26) and without endometriosis (n = 25). Read More

Sci Rep 2022 Jun 25;12(1):10820. Epub 2022 Jun 25.

Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, 270 Dong-an Road, Shanghai, 200032, China.

Clear cell carcinoma (CCC) of the abdominal wall is a rare and agressive disease. We aim to elucidate the clinical and prognostic characteristics of this disease. Medical records of ten patients diagnosed with CCC of the abdominal wall at Fudan University Shanghai Cancer Center were reviewed. Read More

J Minim Invasive Gynecol 2022 Jun 22. Epub 2022 Jun 22.

Obstetrics & Gynecology, Hurley Medical Center/Michigan State University, Flint, MI.

Am J Reprod Immunol 2022 Jun 25. Epub 2022 Jun 25.

Clinical Research Laboratory, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, 400012, India.

Endometriosis is a public health disorder affecting ∼ 247 million women globally and ∼ 42 million women in India. Women with endometriosis suffer from dysmenorrhea, chronic pelvic pain, dyspareunia, dyschezia, fatigue, depression, and infertility leading to significant socioeconomic impact and morbidity. The etiology of endometriosis is not understood even after 100 years of research. Read More

J Minim Invasive Gynecol 2022 Jun 21. Epub 2022 Jun 21.

Division of Gynecology, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals.

Study Objective: To demonstrate a new wet lab model for training in conservative bowel endometriosis surgery (shaving and discoid resection) DESIGN: Video demonstration MATERIALS AND METHODS: 1) Modeling deep infiltrating endometriosis using cryopreserved porcine rectum. 2) Conservative resection (shaving and discoid resection) using cold scissor and CO2 laser (free beam and fiber). 3) Discoid resection RESULTS: In this video we present a new training model for improving the surgical management of bowel endometriosis. Read More

Hum Reprod Open 2022 10;2022(3):hoac025. Epub 2022 Jun 10.

Division of Women's Health, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Study Question: Does endometriosis affect live birth following donor oocyte recipient versus autologous IVF?

Summary Answer: There was no significant difference in the live birth rate (LBR) in women with endometriosis undergoing donor oocyte recipient cycles versus autologous IVF cycles.

What Is Known Already: For infertile women with endometriosis, IVF is often considered as a treatment option. Lower implantation and pregnancy rates have been observed following IVF in women with endometriosis. Read More

Molecules 2022 Jun 20;27(12). Epub 2022 Jun 20.

Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School, Brown University, Providence, RI 02903, USA.

The high expression of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) mRNA has been found in breast cancer tissues and endometriosis. The current research focuses on preparing a range of organic molecules as 17β-HSD1 inhibitors. Among them, the derivatives of hydroxyphenyl naphthol steroidomimetics are reported as one of the potential groups of inhibitors for treating estrogen-dependent disorders. Read More

Medicina (Kaunas) 2022 Jun 13;58(6). Epub 2022 Jun 13.

Gynecology and Obstetrics Unit, Department of Medicine, Surgery and Dentistry Schola Medica Salernitana, University of Salerno, 84081 Baronissi, Italy.

: To assess the use of near infrared radiation imaging after injection of indocyanine green (NIR-ICG) during laparoscopic treatment of benign gynecologic conditions. : A systematic review of the literature was performed searching 7 electronic databases from their inception to March 2022 for all studies which assessed the use of NIR-ICG during laparoscopic treatment of benign gynecological conditions. : 16 studies (1 randomized within subject clinical trial and 15 observational studies) with 416 women were included. Read More

J Pers Med 2022 Jun 16;12(6). Epub 2022 Jun 16.

Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, C/Arzobispo Morcillo 2, 28049 Madrid, Spain.

Endometriosis is a gynecological pathology that affects between 6 and 15% of women of childbearing age. One of the manifestations is intestinal deep infiltrating endometriosis. This condition may force patients to resort to surgical treatment, often ending in resection. Read More

J Pers Med 2022 May 24;12(6). Epub 2022 May 24.

Faculty of Medicine, Institute of Biochemistry and Molecular Genetics, University of Ljubljana, 1000 Ljubljana, Slovenia.

Endometriosis is an estrogen-dependent inflammatory disease affecting women in their reproductive age. Due to non-specific symptoms, women with endometriosis are often misdiagnosed or are accurately diagnosed only after several years. Diagnosis of peritoneal endometriosis is especially challenging and relies only on laparoscopic surgery. Read More

Int J Mol Sci 2022 Jun 17;23(12). Epub 2022 Jun 17.

Merck Healthcare KGaA, 64293 Darmstadt, Germany.

Although the full primary structures of the alfa and beta subunits of reference r-hFSH-alfa and its biosimilars are identical, cell context-dependent differences in the expressing cell lines and manufacturing process can lead to variations in glycosylation profiles. In the present study, we compared the structural features of reference r-hFSH-alfa with those of five biosimilar preparations approved in different global regions outside Europe (Primapur, Jin Sai Heng, Follitrope, Folisurge, and Corneumon) with respect to glycosylation, macro- and microheterogeneity, and other post-translational modifications and higher order structure. The mean proportion of -glycosylation-site occupancy was highest in reference r-hFSH-alfa, decreasing sequentially in Primapur, Jin Sai Heng, Corneumon, Follisurge and Follitrope, respectively. Read More

Biomedicines 2022 Jun 14;10(6). Epub 2022 Jun 14.

Center for Prevention and Therapy of Gynecological Cancers, Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.

Endometriosis is a chronic disease characterized by the ectopic localization of the endometrial tissue in the peritoneal cavity. Consequently, it causes local pathological changes and systemic symptoms, affecting at least one in every ten women. This disease is difficult to diagnose early, it is prone to dissemination, is difficult to eradicate, tends to recur, and is regarded as "a cancer of no kill". Read More

Antioxidants (Basel) 2022 Jun 14;11(6). Epub 2022 Jun 14.

Human Reproduction Division, Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14048-900, SP, Brazil.

Endometriosis-related infertility is associated with oxidative stress (OS). The present study aims to compare serum OS markers of infertile women with endometriosis and controls during the follicular phase of the natural cycle (D1), after pituitary downregulation using a GnRH agonist (D2), after controlled ovarian stimulation (COS) on the day of human chorionic gonadotropin administration (D3), and on the day of oocyte retrieval (D4). One hundred and eight serum samples (58 controls and 35 early and 18 advanced endometriosis cases) were collected at these four timepoints. Read More

Reprod Sci 2022 Jun 23. Epub 2022 Jun 23.

Instituto de Investigaciones Químicas, CSIC-US, Seville, Spain.

Neurokinin B (NKB) and its cognate receptor, NK3R, play a key role in the regulation of reproduction. NKB belongs to the family of tachykinins, which also includes substance P and neurokinin A, both encoded by the by the gene TAC1, and hemokinin-1, encoded by the TAC4 gene. In addition to NK3R, tachykinin effects are mediated by NK1R and NK2R, encoded by the genes TACR1 and TACR2, respectively. Read More

Ann Med Surg (Lond) 2022 Jun 23;78:103809. Epub 2022 May 23.

Clinic of Gynecology, Obstetrics and Gynecological Oncology, University Hospital for Gynecology, Pius-Hospital Oldenburg, Medical Campus University of Oldenburg, Germany.

Background: Adenomyosis can cause symptoms like dysmenorrhea, dyspareunia, pelvic pain and bleeding disorders and is related to subfertility and obstetrical complications. The disease is probably underestimated and underdiagnosed because of difficulties in reliable clinical examination and imaging results. The age-related prevalence of adenomyosis still remains unclear. Read More

Ann Med 2022 Dec;54(1):1444-1451

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: To clarify clinical importance of serum CA19-9, CA-125, and plasma D-dimer (D-D) levels in detecting spontaneously ruptured ovarian endometriosis (OE).

Materials And Methods: We retrospectively examined 173 patients with endometriosis out of 735 cases of OE between 2013 and 2019. Among these, 21 cases were diagnosed as "spontaneously ruptured" after surgery, while the remaining cases were unruptured. Read More

Sci Rep 2022 Jun 22;12(1):10507. Epub 2022 Jun 22.

Department of Surgery, Minimally Invasive Surgery Research Center, Division of Minimally Invasive and Bariatric Surgery, Rasool-e Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

In patients with BMI ≥ 50 kg/m, it is difficult to select an appropriate procedure that can lead to optimum results. This study aims to evaluate mid-term weight loss outcomes in patients with BMI ≥ 50 kg/m following one anastomosis gastric bypass (OAGB) as a one-stage procedure. A prospective study was conducted on patients with BMI ≥ 50 kg/m, aged 18 years and above who had undergone primary OAGB from January 2016 to February 2019 with at least two years follow-ups. Read More

J Minim Invasive Gynecol 2022 Jun 19. Epub 2022 Jun 19.

Endoscopica Malzoni, Center for Advanced Endoscopic Gynecologic Surgery, Avellino, Italy.

Study Objectives: To assess the value of combined transvaginal/transabdominal (TV/TA) ultrasonographic evaluation performed by experienced examiners for deep infiltrating endometriosis (DIE) lesions of the retrocervical (torus uterinus and uterosacral ligaments) and parametrial areas, and summarize the features and anatomical criteria for identification of these lesions and their extent in the above-mentioned pelvic compartments.

Design: Retrospective study.

Setting: A specialized endometriosis center in Avellino, Italy PATIENTS: A retrospective cohort of patients who underwent laparoscopic surgery for clinically suspected DIE between January 1, 2014, and December 31, 2018, with a dedicated ultrasound (US) evaluation performed no more than 1 month before the intervention. Read More

JMIR Med Inform 2022 Jun 22;10(6):e34753. Epub 2022 Jun 22.

Department of Obstetrics and Gynecology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Cervical cancer has been recognized as a preventable type of cancer. As the assessment of all the risk factors of a disease is challenging for physicians, information technology and risk assessment models have been used to estimate the degree of risk.

Objective: The aim of this study was to develop a clinical decision support system to assess the risk of cervical cancer. Read More

Hum Reprod 2022 Jun 21. Epub 2022 Jun 21.

Gynaecology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Study Question: Is the Subjective Impact of Dyspareunia Inventory (SIDI) a reliable tool to examine the experience of dyspareunia in the context of endometriosis?

Summary Answer: In this study, the SIDI showed good structural and psychometric properties, and thus can be used as a reliable questionnaire to assess the impact of endometriosis-related dyspareunia on multiple dimensions, such as sexuality and intimate relationships.

What Is Known Already: In the endometriosis population, dyspareunia has a tremendous negative impact on psychological health, overall sexual function and couple relationships. However, there is a paucity of tools that can be effectively used in either research or clinical practice to assess the subjective components of the dyspareunia experience, including coping strategies to deal with the pain. Read More

Comput Intell Neurosci 2022 11;2022:3123310. Epub 2022 Jun 11.

Department of Gynecology, West China Second University Hospital, Chengdu 610041, Sichuan, China.

This research was aimed to study the application value of the magnetic resonance imaging (MRI) diagnosis under artificial intelligence algorithms and the effect of nursing intervention on patients with gynecological ovarian endometriosis. 116 patients with ovarian endometriosis were randomly divided into a control group (routine nursing) and an experimental group (comprehensive nursing), with 58 cases in each group. The artificial intelligence fuzzy C-means (FCM) clustering algorithm was proposed and used in the MRI diagnosis of ovarian endometriosis. Read More

Commun Biol 2022 Jun 20;5(1):600. Epub 2022 Jun 20.

The Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.

Cellular development is tightly regulated as mature cells with aberrant functions may initiate pathogenic processes. The endometrium is a highly regenerative tissue, shedding and regenerating each month. Endometrial stromal fibroblasts are regenerated each cycle from mesenchymal stem cells and play a pivotal role in endometriosis, a disease characterised by endometrial cells that grow outside the uterus. Read More

J Surg Case Rep 2022 Jun 15;2022(6):rjac282. Epub 2022 Jun 15.

Department of Surgery, Self-Defence Forces Central Hospital, Setagaya, Japan.

Endometriosis is characterized by the presence of an ectopic endometrial gland. Intestinal endometriosis with small bowel obstruction is uncommon. In this case, a 37-year-old woman with no history of endometriosis presented with a chief complaint of abdominal pain. Read More

Cureus 2022 May 16;14(5):e25055. Epub 2022 May 16.

Pathology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, IND.

Introduction The appendix is considered an appendage of little value and is often treated disdainfully, be it as part of evolutionary process, on a grossing table, under a microscope or while archiving specimens and slides. It is only recently, with data indicating its importance in gut immunity and as the origin of pseudomyxoma, that its space in a human body appears vindicated. Aim Our aim was to screen the histopathologic spectrum of appendix lesions observed in our hospital for rare, incidental or clinico-radiologically uncertain lesions that would help emphasize a necessary seriousness in its sampling. Read More

Zhongguo Zhong Yao Za Zhi 2022 Jun;47(11):3073-3087

the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510405, China.

Network Meta-analysis was performed to systematically compare the efficacy of different Chinese patent medicines for activating blood and resolving stasis in the treatment of endometriosis and to provide evidence-based references for clinical medication regimens. The relevant randomized controlled trials(RCTs) involving Chinese patent medicines combined with conventional treatment(experimental group) vs conventional treatment(control group) were retrieved from Chinese and English literature databases. The bias risk assessment tool recommended in Cochrane handbook 5. Read More

Lancet 2022 06;399(10343):2267-2279

Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.

Background: Endometriosis is a common cause of pelvic pain in women, for which current treatment options are suboptimal. Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, combined with estradiol and a progestin, was evaluated for treatment of endometriosis-associated pain.

Methods: In these two replicate, phase 3, multicentre, randomised, double-blind, placebo-controlled trials at 219 community and hospital research centres in Africa, Australasia, Europe, North America, and South America, we randomly assigned women aged 18-50 years with surgically or directly visualised endometriosis with or without histological confirmation, or with histological diagnosis alone. Read More