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Eur J Obstet Gynecol Reprod Biol 2021 May 4;262:7-12. Epub 2021 May 4.

Department of Obstetrics and Gynaecology, Erlangen University Hospital, Erlangen, Germany; Friedrich Alexander University of Erlangen-Nürnberg, Erlangen, Germany.

Objective: This study aimed to provide an overview of the extent to which women with endometriosis are informed about, interested in, and make use of CAM, and to evaluate which of the methods are most often applied.

Study Design: A retrospective, two-center cohort study was conducted using a validated questionnaire among women with laparoscopically confirmed endometriosis at two urban teaching hospitals, certified as endometriosis centres.

Results: A total of 592 patients were included in the study and received the questionnaire; 114 (19. Read More

J Obstet Gynaecol Can 2021 May 10. Epub 2021 May 10.

Professor Emeritus, University of Tennessee Health Science Centre, Memphis Tennessee, USA; Institutional Review Board, Virginia Commonwealth University, Richmond, Virginia, USA.

Objective: To evaluate the prevalence of endometriosis and peritoneal pockets and to analyze whether these pockets are associated with pain.

Methods: Analysis of prospectively registered data of all women undergoing laparoscopy for infertility or pelvic pain between 1988 and 2011 at KU Leuven University Hospital.

Results: Of 4497 women, 191 had 238 pockets, with a prevalence of 4. Read More

J Minim Invasive Gynecol 2021 May 10. Epub 2021 May 10.

Gynaecology Department. Institute Clinic of Gynaecology, Obstetrics and Neonatology, Hospital Clinic. Faculty of Medicine, University of Barcelona, Institut d`Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain.

Study Objective: We performed a long-term follow-up to quantify the impairment of sexual quality of life (SQL) and health-related quality of life (HRQL) in sexually active women following laparoscopic excision of deep infiltrating endometriosis (DIE).

Design: Prospective case-control study.

Setting: Hospital Clinic of Barcelona. Read More

Aust N Z J Obstet Gynaecol 2021 May 13. Epub 2021 May 13.

Anaesthesia and Pain Medicine, Mater Health Services, Brisbane, Queensland, Australia.

Persistent pelvic pain (PPP) is an important cause of psychological distress and productivity loss in women. In 2017, a multidisciplinary clinic was established to care for Queensland women with PPP. By analysing clinic and emergency department data, we found 19% fewer patients required any presentation to the emergency department for exacerbations of pelvic pain (P = 0. Read More

Hum Reprod 2021 May 13. Epub 2021 May 13.

Imperial College Healthcare NHS Trust, St Mary's Hospital, Department of Obstetrics and Gynaecology, London W2 1NY, UK.

PLoS One 2021 13;16(5):e0251385. Epub 2021 May 13.

Department of Anatomic Pathology and Forensic Medicine, College of Health Sciences, Nile University of Nigeria, Abuja, Nigeria.

The diagnosis of thoracic endometriosis (TE) is challenging, hence resulting in under-diagnosis as well as long delays before arriving at a correct definitive diagnosis. Our aim is to review the histopathological findings in TE, summarise the diagnostic features, identify any major histo-morphological indicator(s) hitherto unrecognised as such, suggest diagnostic criteria; all with the aim of improving the diagnostic capacity and reducing observer error even where the clinical suspicion is low. A case-control study in which a search in the pathology archives of a referral hospital over a 10-year period was conducted. Read More

Surg Case Rep 2021 May 13;7(1):121. Epub 2021 May 13.

Department of Surgery, Sapporo Higashi Tokushukai Hospital, 3-1, N-33, E-14, Higahi-ku, Sapporo, Hokkaido, 0650033, Japan.

Background: Hydrocele of canal of Nuck (HCN) is a rare disease in adult female. The diagnosis and treatment of HCN is still a challenge for surgeons.

Case Presentation: A 56-year-old female presented with recent onset of occasional pain during exercise and an asymptomatic left groin swelling. Read More

Mol Hum Reprod 2021 May 13. Epub 2021 May 13.

Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo, 192-0392, Japan.

Endometriosis is characterised by inflammation and fibrotic changes. Our previous study using a mouse model showed that proinflammatory factors present in peritoneal hemorrhage exacerbated inflammation in endometriosis-like grafts, at least in part through the activation of prostaglandin (PG) E2 receptor and protease-activated receptor (PAR). In addition, hypoxia is a well-known inducer of fibrosis that may be associated with epithelial-mesenchymal transition (EMT). Read More

Am Fam Physician 2021 May;103(10):597-604

AdventHealth Orlando Family Medicine Residency Program, Orlando, FL, USA.

Dyspareunia is recurrent or persistent pain with sexual intercourse that causes distress. It affects approximately 10% to 20% of U.S. Read More

Hum Reprod 2021 May 13. Epub 2021 May 13.

Department of Obstetrics and Gynaecology, Imperial College Healthcare NHS Trust, St Mary's Hospital, London, UK.

Proc ACM Hum Comput Interact 2021 Jan;4(CSCW3)

Columbia University, Department of Biomedical Informatics.

In chronic conditions, patients and providers need support in understanding and managing illness over time. Focusing on endometriosis, an enigmatic chronic condition, we conducted interviews with specialists and focus groups with patients to elicit their work in care specifically pertaining to dealing with an enigmatic disease, both independently and in partnership, and how technology could support these efforts. We found that the work to care for the illness, including reflecting on the illness experience and planning for care, is significantly compounded by the complex nature of the disease: enigmatic condition means uncertainty and frustration in care and management; the multi-factorial and systemic features of endometriosis without any guidance to interpret them overwhelm patients and providers; the different temporal resolutions of this chronic condition confuse both patients and provides; and patients and providers negotiate medical knowledge and expertise in an attempt to align their perspectives. Read More

J Ovarian Res 2021 May 12;14(1):66. Epub 2021 May 12.

Reproductive Endocrinology and Infertility Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 10400, Bangkok, Thailand.

Background: Dysregulation of immune response is associated with development of endometriosis. The study aim was to evaluate effect of combined oral contraceptive pills (COCs) consisting of ethinyl estradiol (EE) and desogestrel on the expression of macrophage, natural killer cells, and regulatory T cells of ovarian endometriotic cysts.

Methods: Endometriotic cyst wall tissues were collected from women with endometriosis who were treated (n = 22) with COCs (one table per day of EE 0. Read More

PLoS One 2021 12;16(5):e0251372. Epub 2021 May 12.

Research Unit EA7285, Risk and Safety in Clinical Medicine for Women and Perinatal Health, Versailles St-Quentin University, Montigny-le-Bretonneux, Versailles, France.

Introduction: The Endometriosis Fertility Index (EFI) is a validated score for predicting the postoperative spontaneous pregnancy rate in patients undergoing endometriosis surgery. However, the practical use of the EFI to advise patients about postoperative fertility management is unclear.

Materials And Methods: All patients participating in the ENDOQUAL study-a prospective observational bi-center cohort study conducted between 01/2012 and 06/2018-who underwent surgery for infertility were asked to complete a questionnaire collecting time and mode of conception. Read More

Minerva Obstet Gynecol 2021 May 12. Epub 2021 May 12.

Department of Maternal and Child Health and Urological Sciences, Sapienza, University of Rome, Policlinico Umberto I, Rome, Italy -

Minerva Obstet Gynecol 2021 May 12. Epub 2021 May 12.

Latifa Hospital, Dubai, Unated Arab Emirates.

Endometriosis and pelvic pain are associated. However, only half of the subtle and typical, and not all cystic and deep lesions are painful. The mechanism of the pain is explained by cyclical trauma and repair, an inflammatory reaction, activation of nociceptors up to 2. Read More

Minerva Obstet Gynecol 2021 May 12. Epub 2021 May 12.

Department of Obstetrics and Gynaecology, Second Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic.

Uterine artery pseudoaneurysm (UAP) is a rare complication during pregnancy that can cause serious consequences in both the pregnant woman and the fetus. Herein, we have described the cases of two pregnant women with UAP. Both patients had a history of laparoscopy for management of endometrioid ovarian cysts. Read More

Respirol Case Rep 2021 Jun 7;9(6):e00755. Epub 2021 May 7.

Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX USA.

Catamenial haemoptysis, the expectoration of blood during menses, has not been extensively reported in the cystic fibrosis (CF) literature. We describe four cases (age range: 25-34 years) of catamenial haemoptysis across four CF centres in the United States. These cases may represent thoracic endometriosis versus hormonal fluctuations in airway inflammation or infection resulting in bronchial artery bleeding. Read More

Gynecol Endocrinol 2021 May 11:1-5. Epub 2021 May 11.

Department of Obstetrics and Gynaecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.

Aim: Study the effect of low-dose aspirin on the endometrial receptivity in endometriosis rat models.

Materials And Methods: This study is to explore the expressions of progesterone receptor and LIF among three groups of endometriosis rat models: control group ( = 12), EMs group ( = 15), and aspirin group ( = 17). The expressions of progesterone receptor (PR), PRA, PRB, and leukemia inhibitory factor receptor (LIFR) in eutopic endometrium were determined using immunohistochemistry technology, western blot, and qRT-PCR. Read More

Cochrane Database Syst Rev 2021 May 11;5:CD011169. Epub 2021 May 11.

Isala Hospitals Zwolle, Zwolle, Netherlands.

Background: Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. This chronic and recurring condition occurs in women of reproductive age. It is a common cause of pain or infertility and can cause non-specific symptoms such as lower back pain, dyspareunia (pain during or after intercourse), and dysmenorrhoea (menstrual pain). Read More

Int J Clin Pract 2021 May 11:e14350. Epub 2021 May 11.

Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas.

Aims: Deep infiltrative endometriosis (DIE) may cause pelvic pain and thus negatively affect the function of different structures. We hypothesized that women with DIE may have dysfunctions of the pelvic floor muscles (PFM) and lower limb muscles (LLM).

Methods: This cross-sectional study included 160 women (80 with DIE under hormonal treatment and 80 women without DIE), who were assessed to determine the presence of pelvic symptoms (dysmenorrhea, chronic pelvic pain (CPP), deep/penetration dyspareunia, dysuria, dyschezia, and vulvodynia), PFM function (PERFECT scheme, presence of hypertonia and trigger points, and muscle contraction and relaxation), abdominal muscle pain (Carnett's test), and muscle shortening in LLM (Thomas, Pace, and Ober tests). Read More

Surg Case Rep 2021 May 11;7(1):117. Epub 2021 May 11.

Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Ectopic decidua is the presence of decidual tissue outside the uterus. Ectopic decidua of the appendix is a rare entity that can present with abdominal symptoms mimicking appendicitis. We report a case of a 39-year-old female patient at 27 weeks gestational age with a 2-day history of right lower quadrant abdominal pain. Read More

Food Funct 2021 May 10. Epub 2021 May 10.

Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge, CB4 0WF, UK.

Retraction of 'Ginsenoside Rf alleviates dysmenorrhea and inflammation through the BDNF-TrkB-CREB pathway in a rat model of endometriosis' by Xuying Qin et al., Food Funct., 2019, 10, 244-249, DOI: 10. Read More

PLoS Med 2021 May 10;18(5):e1003603. Epub 2021 May 10.

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Background: Increased risk of miscarriage has been reported for women with specific chronic health conditions. A broader investigation of chronic diseases and miscarriage risk may uncover patterns across categories of illness. The objective of this study was to study the risk of miscarriage according to various preexisting chronic diseases. Read More

Int J Med Sci 2021 16;18(11):2401-2408. Epub 2021 Apr 16.

College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China.

Endometriosis (EMs) is recorded as in traditional Chinese medicine (TCM) books. Guizhi Fuling Pills (GFPs), a classic prescription for promoting blood circulation and removing blood stasis, is widely used for women's blood stasis diseases represented by . At present, it has been applied to treat EMs in clinical settings. Read More

Ann Palliat Med 2021 Apr;10(4):4728-4735

Department of Gynecological Oncology, Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin, China.

Background: To investigate the relationships of cancer antigen (CA) 125, CA 19-9, prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), fibrinogen (FIB), and D-dimer values with ovarian endometriosis (OEM), and to explore the validation of biomarkers for noninvasive preoperative evaluation of patients with severe OEM.

Methods: This retrospective case-control study included 413 women with OEM (of whom 143 cases were stage I to II, 139 cases were stage III, and 131 cases were stage IV, respectively) and 158 women without OEM as controls. Subjects' serum CA-125 and CA19-9 levels, and coagulation test results (serum PT, aPTT, and D-dimer values) were evaluated. Read More

Sci Total Environ 2021 Apr 28;786:147371. Epub 2021 Apr 28.

Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan; Research Center of Environmental Trace Toxic Substances, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan. Electronic address:

Phthalate esters (PAEs) are one of the most widely used plasticizers in polymer products and humans are increasingly exposed to them. The constant exposure to PAEs-contained products has raised some concerns against human health. Thus, the impacts of PAEs and their metabolites on human health require a comprehensive study for a better understanding of the associated risks. Read More

J Minim Invasive Gynecol 2021 May 5. Epub 2021 May 5.

Department of Obstetrics and Gynecology, Hôpital Universitaire de la Croix Rousse, Hospices Civils de Lyon, Université Lyon 1, France.

Study Objectives: To describe the surgical management and the risks of postoperative complications of patients suffering from urinary tract endometriosis (UTE) in France in 2017.

Design: Multicentric retrospective cohort pilot study.

Setting: Department of Gynecology in 31 expert endometriosis centers. Read More

Am J Pathol 2021 May 5. Epub 2021 May 5.

Department of Obstetrics, Gynecology, & Reproductive Medicine, Yale School of Medicine, New Haven, CT, USA.

Hyperactivation of the CXCL12-CXCR4 axis occurs in endometriosis; the therapeutic potential of treatments aimed at global inhibition of the axis was recently demonstrated. As CXCR4 is predominantly expressed on epithelial cells in the uterus, our aim was to explore the effects of targeted disruption of CXCR4 in endometriosis lesions. Uteri derived from adult female mice homozygous for a floxed allele of CXCR4 and co-expressing Cre recombinase under control of progesterone receptor were sutured onto the peritoneum of cycling GFP+ host mice. Read More

Clin Transl Sci 2021 May 7. Epub 2021 May 7.

Clinical Pharmacology and Pharmacometrics, AbbVie Inc, North Chicago, Illinois, USA.

Elagolix is a novel, oral gonadotropin-releasing hormone receptor antagonist indicated for the management of moderate to severe pain associated with endometriosis and heavy menstrual bleeding associated with uterine fibroids. Consistent with its mechanism of action, elagolix exhibited dose-dependent suppression of estradiol (E2) in clinical studies. A dose-response model that describes the relationship between elagolix dosages and average E2 levels was combined with a previously published quantitative systems pharmacology (QSP) model of calcium homeostasis to predict bone mineral density (BMD) changes during and following elagolix treatment. Read More

Endocrinology 2021 May 8. Epub 2021 May 8.

Dept. of Pathology, University of Colorado Anschutz Medical Campus.

The WNT family of proteins are crucial in numerous developmental pathways and tissue homeostasis. WNT4, in particular, is uniquely implicated in development of the female phenotype in the fetus, and in the maintenance of Müllerian and reproductive tissues. WNT4 dysfunction or dysregulation can drive sex reversal syndromes, highlighting the key role of WNT4 in sex determination. Read More