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Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Thoracic Surgery, Royal Brompton Hospital.

Mol Hum Reprod 2019 Feb 16. Epub 2019 Feb 16.

Department of Obstetrics and Gynaecology and Gynaecology Research Centre, Royal Women's Hospital, University of Melbourne, Parkville, Victoria, Australia.

Endometriotic lesions are composed in part of endometrial-like stromal cells, however, there is a shortage of immortalized human endometrial stromal cultures available for research. As genetic factors play a role in endometriosis risk, it is important that genotype is also incorporated into analysis of pathological mechanisms. Human telomerase reverse transcriptase (hTERT) immortalization (using Lenti-hTERT-green fluorescent protein virus) took place following genotype selection; 13 patients homozygous for either the risk or non-risk 'other' allele for one or more important endometriosis risk single nucleotide polymorphism on chromosome 1p36. Read More

Diagn Interv Imaging 2019 Feb 12. Epub 2019 Feb 12.

Department of Radiology, Hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.

Endometriosis is a chronic gynecological condition that affects primarily young women. Imaging plays a pivotal role for the diagnosis and pre-surgical mapping of the disease. By comparison, the role of imaging in the identification of disease recurrence and postoperative complications are not well established. Read More

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Department of Obstetrics and Gynecology; National Taiwan University Hospital, Taipei 100, Taiwan.

The objective of this article was to report the clinicopathological characteristics, treatment modalities, and outcomes of patients with clear cell carcinoma (CCC) of the abdominal wall. Medical records of six patients diagnosed with CCC of the abdominal wall between May 2003 and May 2018 at the National Taiwan University Hospital were reviewed. All patients had prior obstetric or gynecologic surgeries. Read More

Case Rep Obstet Gynecol 2019 15;2019:1920430. Epub 2019 Jan 15.

Advanced Urology Associates, 1541 Riverboat Center Drive, Joliet, IL 60431, USA.

Ureteral injury is an uncommon but potentially morbid complication following any open or endoscopic pelvic procedure. Gynecologic surgeries alone make up 50 percent of nonurologic ureteral injuries leading to prolonged hospital stays, secondary interventions, and potential loss of renal function. The use of AmnioFix ® a processed dehydrated, immunologically privileged cellular amniotic membrane allograft has been well established in urologic and gynecologic procedures. Read More

BMC Res Notes 2019 Feb 14;12(1):88. Epub 2019 Feb 14.

Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia.

Objective: Currently, it is estimated that one in 10 women of reproductive age are affected by the reproductive condition known as endometriosis. However, there has been limited research and policy attention on the prevalence of endometriosis in Australia. Utilising a nationally-representative Australian sample (N = 2025), this study aimed to report on the prevalence of endometriosis in the general population and to examine the sociodemographic factors associated with the condition. Read More

Reprod Sci 2019 Feb 14:1933719119828095. Epub 2019 Feb 14.

1 Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan.

In cases of extragenital endometriosis or microscopic endometriosis lesions, pathological diagnosis can be challenging because endometriotic stroma and glands represent only a minor component of fibrotic endometriotic lesions. For better accuracy of diagnosis, the development of a sensitive and specific epithelial marker is beneficial. Previous studies showed that PAX8 is a highly sensitive and specific marker for primary and metastatic Mullerian epithelial tumors. Read More

Reprod Sci 2019 Feb 14:1933719119828066. Epub 2019 Feb 14.

1 Shanghai OB/GYN Hospital, Fudan University, Shanghai, China.

Despite the demonstrated efficacy of surgical treatment of endometriosis, recurrence after surgery still remains a formidable challenge. Surgery, especially when performed repeatedly, decreases ovarian reserve. Clearly, control of recurrence is an unmet medical need. Read More

Expert Opin Biol Ther 2019 Feb 14. Epub 2019 Feb 14.

a Academic Unit of Obstetrics and Gynecology , Ospedale Policlinico San Martino , Largo R. Benzi 10, 16132 Genoa , Italy.

Introduction: Endometriosis is a chronic benign estrogen dependent disease characterized by the presence of endometriotic glands and stroma outside the uterine cavity. Although combined hormonal contraceptives and progestins, currently available first-line treatments for endometriosis, are efficacious and well tolerated for treating disease-related pain, some women experience partial or no improvement of pain or its recurrence is frequent after discontinuation of the therapies. For these reasons, new drugs are under investigation for the treatment of endometriosis. Read More

Urologiia 2018 Oct(4):118-121

Ya.L. Tsivyan Novosibirsk Scientific Research Institute of Traumatology and Orthopedics of Minzdrav of Russia, Novosibirsk, Russia.

Urinary endometriosis a rare condition accounting for 1-5.5% of all of the extragenital endometriosis locations. Bladder endometriosis is the most common form of urinary endometriosis, comprising 85% of cases. Read More

Cell Death Dis 2019 Feb 13;10(2):144. Epub 2019 Feb 13.

Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3 Qingchun East Road, Jianggan District, 310016, Hangzhou, China.

Endometriosis is associated with benign but adversely developed cysts in the extrauterine environment. The oxidative imbalanced environment induces DNA damage and affects cell cycle progression of endometrial stromal cells (ESCs) and endometrial epithelial cells, but how endometriotic cells maintain proliferation in the presence of oxidative stress is not clear. Growing evidence has indicated that the ectopic hypoxic microenvironment and oxidative stress can stimulate the growth of endometriotic cells, which is mainly due to the increase of HIF-1α. Read More

Reprod Biol Endocrinol 2019 Feb 13;17(1):22. Epub 2019 Feb 13.

Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.

Background: Previous studies, which were primarily based on the fluorescent in-situ hybridisation (FISH) technique, revealed conflicting evidence regarding male foetal microchimerism in endometriosis. FISH is a relatively less sensitive technique, as it is performed on a small portion of the sample. Additionally, the probes used in the previous studies specifically detected centromeric and telomeric regions of Y chromosome, which are gene-sparse heterochromatised regions. Read More

Clin Radiol 2019 Feb 9. Epub 2019 Feb 9.

Department of Clinical Pharmacy, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Aim: To evaluate the efficacy and safety of the uterine artery embolisation (UAE) in combination with methotrexate (MTX) for conservative management of placental adhesive disorders.

Material And Methods: Patients with placental adhesive disorders (including accreta, increta, and percreta lesions) that were treated with UAE in combination with MTX were identified and were followed prospectively for outcomes including uterine preservation and complications.

Results: Twenty-six patients were identified who had the diagnosis of abnormal placenta implantation during this study. Read More

Reprod Biol Endocrinol 2019 Feb 12;17(1):21. Epub 2019 Feb 12.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Haidian district, North garden road, No 49, Beijing, People's Republic of China.

Background: Endometriosis is thought to affect the effectiveness of ART by an increased risk of miscarriage. We aimed to investigate the impact of endometriosis in women achieving singleton pregnancies through IVF fresh cycles and risk of miscarriage.

Methods: This retrospective cohort study included all women undergoing a first IVF cycle and achieving singleton pregnancies after fresh embryo transfer in a tertiary university hospital reproductive medical center between January 2008 and June 2016. Read More

Mol Cell Endocrinol 2019 Feb 9. Epub 2019 Feb 9.

Morphological Sciences Program, Biomedical Sciences Institute, Federal University of Rio de Janeiro - UFRJ, Rio de Janeiro, RJ, Brazil.

This study aimed to analyze galectin-3 importance in endometriotic lesions development and the effect of recombinant Gal-3 carbohydrate recognition domain (Gal3C) in experimental endometriosis treatment. Experimental endometriosis was induced in WT and Gal-3-/- mice. Initially developed lesions were macroscopically and histologically analyzed, including immunohistochemical analysis. Read More

J Natl Cancer Inst 2019 Feb 11. Epub 2019 Feb 11.

Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Background: Recent studies have called into question the long-held belief that hysterectomy without oophorectomy protects against ovarian cancer. This population-based longitudinal record-linkage study aimed to explore this relationship, overall and by age at hysterectomy, time period, surgery type, and indication for hysterectomy.

Methods: We followed the female adult Western Australian population (837,942 women) across a 27-year period using linked electoral, hospital, births, deaths, and cancer records. Read More

Hum Reprod 2019 Feb 12. Epub 2019 Feb 12.

Département 'Développement, Reproduction et Cancer', Institut Cochin, INSERM U1016 (Professeur Batteux), Université Paris Descartes, Sorbonne Paris Cité, 22 Rue Méchain, Paris, France.

Study Question: Is endometriosis associated with aberrant sialylation patterns and what is the potential impact of such anomalies on cell migratory properties?

Summary Answer: The reduced α-2,6 sialylation patterns in the peritoneal fluid of endometriosis-affected women and in stromal and epithelial cells from endometriotic lesions could be associated with enhanced cell migration.

What Is Known Already: Endometriosis is considered to be a benign disease although, like cancer, it has the characteristic of being an invasive disease with cells that have an enhanced capacity to migrate. Aberrant sialylation has been reported in various malignancies and it has been linked to tumour invasion and metastasis. Read More

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

W Xiong, Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wu Han, China.

Oestrogen has been reported to control the invasiveness of endometrial stromal cells in endometriosis. Notch signalling, a master regulator of cell invasion in tumours, is regulated by oestrogen in other diseases and hyperactivated in endometriotic stromal cells. Therefore, we hypothesized that an interaction between Notch signalling and oestrogen may exist in the regulation of endometrial stromal cell invasion, which is essential for the development of endometriosis. Read More

Sci Rep 2019 Feb 11;9(1):1779. Epub 2019 Feb 11.

Laboratory of Endometrium, Endometriosis & Reproductive Medicine, Department of Development and Regeneration, KU Leuven, Herestraat 49 box 611, 3000, Leuven, Belgium.

Successful pregnancy requires the establishment of a complex dialogue between the implanting embryo and the endometrium. Knowledge regarding molecular candidates involved in this early communication process is inadequate due to limited access to primary human endometrial epithelial cells (EEC). Since pseudo-pregnancy in rodents can be induced by mechanical scratching of an appropriately primed uterus, this study aimed to investigate the expression of mechanosensitive ion channels in EEC. Read More

Syst Biol Reprod Med 2019 Feb 11:1-8. Epub 2019 Feb 11.

a Department of Reproductive Medicine , Bahceci Fulya IVF Centre , Istanbul , Turkey.

The aim of this study was to evaluate the possible effects of endometriosis on early embryo development, by comparing the morphokinetic development of embryos obtained from women with clinically confirmed endometriosis with the ones obtained from tubal factor infertility cases. A total of 82 cycles/patients including 53 cycles with endometriosis and 29 cycles with tubal factor infertility were evaluated. A total of 439 embryos were scored for embryo morphokinetics. Read More

Mol Reprod Dev 2019 Feb 11. Epub 2019 Feb 11.

Department of Gynecology, Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei, China.

Endometriosis is a common chronic gynecologic disorder characterized by the presence and growth of endometrial-like tissue outside of the uterine cavity. Although the exact etiology remains unclear, epigenetic modifications, such as DNA methylation, are thought to contribute to the pathogenesis of endometriosis. Here, we used the Illumina Human Methylation 450 K BeadChip Array to analyze the genome-wide DNA methylation profiles of six endometriotic lesions and six eutopic endometria from patients with ovarian endometriosis and six endometria of women without endometriosis. Read More

Ann Transl Med 2018 Dec;6(Suppl 2):S119

Department of Obstetrics & Gynecology, University of Michigan Health System, Ann Arbor, Michigan, USA.

Ann Transl Med 2018 Dec;6(Suppl 2):S106

Fondazione Italiana Endometriosi, Rome, Italy.

Am J Obstet Gynecol 2019 Feb 6. Epub 2019 Feb 6.

Ottawa Hospital Research Institute; University of Ottawa, Department of Obstetrics and Gynecology.

Endometriosis is a common gynecologic condition, affecting approximately 10% of reproductive aged women. It commonly presents with pelvic pain, painful periods, and infertility and can significantly impact one's quality of life. Early exploration into the pathophysiology of this condition identified race as a risk factor for endometriosis, with the condition predominantly identified in white women. Read More

Acta Obstet Gynecol Scand 2019 Feb 8. Epub 2019 Feb 8.

Center for Reproductive Medicine, Taipei Medical University Hospital, Taiwan.

We are pleased to read the recent letter to editor by Barra and Ferrero who have been interested in our recent publication in AOGS. In that report, we demonstrated the decreased expression of Tensin 1 (TNS1) in tissue and serum of women with endometriosis after receiving gonadotropin-releasing-hormone agonist (GnRHa) treatment. In our study, we only recruited patients with ovarian endometriosis as mentioned in the material and methods section. Read More

Med Sci Monit 2019 Feb 9;25:1087-1092. Epub 2019 Feb 9.

Department of Obstetrics and Gynecology, Hallym University Dongtan Sacred Heart Hospital, Kyeonggido, South Korea.

BACKGROUND This study evaluated the performance of serum CYFRA 21-1 and placental growth factor (PIGF) as screening markers for endometriosis. MATERIAL AND METHODS In this prospective study included 81 female patients who underwent laparoscopy to treat benign ovarian tumors. Serum samples were obtained from all study patients before surgery. Read More

J Trace Elem Med Biol 2019 Mar 30;52:157-165. Epub 2018 Dec 30.

Laboratorio de Biología de la Reproducción (LABIR), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis (IMIBIO-SL), CONICET, Ejército de Los Andes 950, CP D5700HHW, San Luis, Argentina. Electronic address:

The present study was conducted to investigate whether the deficiency of tumor necrosis factor receptor p55 (TNFRp55) modulates oxidative/nitrosative stress and metallomic profile into the peritoneal cavity during the experimental endometriosis progression in mice. Female C57BL/6 mice, wild-type (WT) and TNFRp55 knockout (KO) of two months were used. Endometriosis was induced experimentally by autotransplanting three pieces of the right uterine horn to the intestinal mesentery. Read More

Gynecol Endocrinol 2019 Feb 7:1-4. Epub 2019 Feb 7.

a Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital , Capital Medical University , Beijing , China.

Objective: To investigate temporary or long-term changes of AMH after laparoscopic endometrioma cystectomy and its dependency on characteristics of endometriomas.

Methods: One hundred and seventy-one women, open-labeled prospective study; five groups divided according age ≤/> 35, uni-/bilateral, cyst ≤/> 7 cm, coagulation/suture surgery, stage III/IV; between- and within-group analyses after 1, 3, 6, and 12 months.

Results: After 12 months, compared to pretreament, AMH decreased significantly for patients with bilateral cysts, cyst size >7 cm and endometriosis stage IV. Read More

Br J Radiol 2019 Feb 7:20180548. Epub 2019 Feb 7.

2 Department of Gynecology, Azienda Ospedaliero Universitaria (A.O.U.) , Cagliari , Italy.

Objective:: Some recent studies have explored how the experience in the observers change their performance in the endometriosis detection using MRI but the effects of the clinical information remains uncertain. The purpose of this study was to assess the effect of the clinical information in the diagnostic confidence in the MRI diagnosis of endometriosis.

Methods And Materials:: Institutional Review Board was obtained. Read More

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Reproductive Health, Nanjing Maternity and Child Health Care Hospital, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing, P. R. China.

Endometriosis is a chronic inflammatory syndrome and nearly 6%-10% of women are affected by it during the reproductive period. Previous studies have proved that microRNAs (miRNAs) are implicated in the pathogenesis of ovarian endometriosis. In this study, we aimed to investigate that restored miR-488 would effectively inhibit the development of endometriosis. Read More

J Ovarian Res 2019 Feb 6;12(1):14. Epub 2019 Feb 6.

Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Minamikogushi 1-1-1, Ube, 755-8505, Japan.

Background: In ovarian endometriomas (OE), the expression statuses of various steroid hormone receptors are altered compared with their expression statuses in eutopic endometrium (EE). For example, in OE, the expressions of estrogen receptor 1 (ESR1), which encodes ERα, and progesterone receptor (PGR) are downregulated, while the expression of ESR2, which encodes ERβ, is upregulated. The causes of these changes are unclear. Read More

Gynecol Endocrinol 2019 Feb 6:1-3. Epub 2019 Feb 6.

a Department of Gynecology and Gynecological Oncology, Gynecologic Cancer Unit Comprehensive Cancer Center Medical University of Vienna, Vienna , Austria.

In this case report, we present a case of false positive CA 19-9 and CA 125 levels in a patient with suspected endometriotic cysts. The patient is a 34-year-old nulliparous woman with heavy black tea consumption and elevated CA 19-9 and CA 125 levels. After discontinuation of black tea intake and careful exploration of other possible factors, CA 19-9 and CA 125 levels dropped markedly. Read More

Minerva Ginecol 2019 Feb 6. Epub 2019 Feb 6.

Department of Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.

Sexual dysfunctions, particularly sexual pain, are common in adult women of all ages. In patients with endometriosis, a chronic gynaecological pain condition affecting women of reproductive age, sexual pain is the third most common symptom. Multiple biological factors are involved in endometriosis-related sexual pain including tissue damage, inflammation, hormonal changes, alterations within the peripheral and central nervous system and pelvic floor muscle dysfunctions. Read More

Mol Biol Rep 2019 Feb 5. Epub 2019 Feb 5.

Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

The prevalence of poor response to gonadotropin stimulation is approximately 9-24% in women undergoing in vitro fertilization. Interestingly, due to containing a variety of growth factors, platelet-rich plasma (PRP) can play an important role in tissue regeneration and healing. Thus, in this research, we aimed to investigate the intra-ovarian injection of PRP in women with poor ovarian response. Read More

J Comp Eff Res 2019 Feb 6. Epub 2019 Feb 6.

Center for Endometriosis Research & Treatment, University of California, San Diego, La Jolla, CA 92037, USA.

Aim: To assess the cost-effectiveness of elagolix versus leuprolide acetate in women with moderate to severe endometriosis pain.

Methods: A Markov model was developed. The efficacy of leuprolide acetate was derived from statistical prediction models using elagolix trial data. Read More

Gynecol Oncol Res Pract 2019 29;6. Epub 2019 Jan 29.

1Department of pathology, Hassan II University Hospital, Fès, Morocco.

Background: Endometrial stromal sarcoma (ESS) is a rare neoplasm accounting for only 0.2% of female genital tract tumors. The primary extra-uterine location of ESS is an extremely uncommon occurrence. Read More

Thromb Haemost 2019 Feb 5. Epub 2019 Feb 5.

Department of Occupational and Environmental Health, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.

Background:  Since venous thromboembolism (VTE) is one of the causes of maternal mortality, several guidelines recommend prophylaxis using low molecular weight heparin for women in high-risk groups. The number of large population-based studies examining predictors for VTE has been limited, and there has been no study based on a Japanese population.

Objective:  Our objective was to examine VTE risk factor during the pregnancy and post-partum period. Read More

Biol Reprod 2019 Feb 4. Epub 2019 Feb 4.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06520, USA.

MicroRNAs (miRNAs), a class of small non-coding RNA molecules, have been recognized as key post-transcriptional regulators associated with a multitude of human diseases. Global expression profiling studies have uncovered hundreds of miRNAs that are dysregulated in several diseases, and yielded many candidate biomarkers. This review will focus on miRNAs in endometriosis, a common chronic disease affecting nearly 10% of reproductive-aged women, which can cause pelvic pain, infertility, and a myriad of other symptoms. Read More

J Minim Invasive Gynecol 2019 Feb 27;26(2):299-311.e3. Epub 2018 Oct 27.

Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada (Drs. Albert, Alfaraj, Taskin, Havelock, Yong, Allaire, and Bedaiwy). Electronic address:

Controversy exists regarding surgical management of endometriomas in infertile women before in vitro fertilization (IVF) because growing evidence indicates that surgery may impair the ovarian response. The objective of the present systematic review and meta-analysis was to compare surgical and expectant management of endometriomas regarding IVF outcomes. Prospective and retrospective controlled studies were found via the Cochrane Library, Embase, and MEDLINE databases. Read More

Hum Reprod Update 2019 Feb 1. Epub 2019 Feb 1.

Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel.

Background: Ovarian endometrioma is a frequent manifestation of endometriosis in women of reproductive age. Several issues related to its space occupying effects, local reactions and surgical removal continue to be actively debated today. The impact of ovarian endometrioma per se on ovarian reserve is still controversial and the effect of ovarian surgery is still actively discussed. Read More

Biol Reprod 2019 Feb 1. Epub 2019 Feb 1.

Department of Development and Regeneration, Biomedical Sciences Group, KU Leuven (University of Leuven), Belgium.

Endometriosis is an important gynecological disease, affecting 10% of reproductive age women, and associated with pain, infertility, reduced quality of life and high health economic cost. Except for ultrasound detection of ovarian endometriotic cysts, the gold standard for diagnosis is laparoscopy, leading to diagnostic delays of 5-10 years. Accurate noninvasive biomarkers are needed, especially for symptomatic women with a normal gynecological ultrasound, to triage them towards medical or surgical treatment and to monitor their treatment outcome. Read More

Gynecol Obstet Invest 2019 Feb 1:1-10. Epub 2019 Feb 1.

Department of Obstetrics and Gynecology, University of São Paulo Medical School, São Paulo, Brazil.

Objective: The objective of this study was to evaluate cytokines related to natural killer and T-regulatory cells in endometriotic lesions, peritoneal fluid (PF) and the peripheral blood (PB) of patients with deep infiltrative endometriosis.

Study Design: A case-control study was conducted in a tertiary referral hospital. Sixty-four consecutive patients after laparoscopy were divided into 2 groups: with endometriosis (Group A - n = 32) and without endometriosis (Group B - n = 32). Read More

Cell Biochem Biophys 2019 Feb 1. Epub 2019 Feb 1.

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.

The possibility that binuclear dinitrosyl iron complexes with glutathione and cysteine (DNIC-GSН and B-DNIC-Cys) have a strong cytotoxic effect on the growth of endometrioid tumours (EMT) in rats with surgically induced experimental endometriosis established in our previous studies has been supported with experimental data. The increase in the DNIC-GSН or B-DNIC-Cys dose from 10 (in our previous studies) to 20 μmol/kg (after i/p administration to experimental rats) fully suppressed the growth of uterine tissues implanted onto the inner surface of the abdominal wall. At 2 μmol/kg DNIC-GSН, the median value of EMT volume increased from 0 to 15 mm, while the mean size of EMT-from 55 to 77 mm (data from EMT measurements in 10 experimental rats). Read More

Eur J Obstet Gynecol Reprod Biol 2019 Jan 22;234:171-178. Epub 2019 Jan 22.

Acute Gynaecology, Early Pregnancy and Advanced Endosurgery Unit, Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Penrith, NSW, Australia; OMNI Gynaecological Care Centre for Women's Ultrasound and Early Pregnancy, St Leonards, NSW, Australia.

Objective: Evaluate whether symptoms and/or transvaginal ultrasound (TVS) 'soft markers' (ovarian immobility and/or site-specific tenderness (SST)) are associated with endometriosis type/location.

Study Design: Multicenter prospective observational study (January 2009 to February 2013) in tertiary centers for women with chronic pelvic pain who underwent detailed history, specialized TVS, and laparoscopy. Chart findings were collated into a study database. Read More

J Minim Invasive Gynecol 2019 Jan 29. Epub 2019 Jan 29.

Department of Obstetrics & Gynecology, Functional Pelvic Surgery & Neuropelveology, University of Toronto, Toronto, ON, Canada.; Department of Gynecology, Pelvic Neurodysfunction Unit, Federal University of São Paulo, São Paulo, SP, Brazil.

Study Objective: To clarify the relationship of hypogastric nerves (HNs) with several pelvic anatomical landmarks and to assess any anatomical differences between the two sides of the pelvis, both in cadaveric and in vivo dissections.

Design: Prospective observational study (Canadian Task Force II-1).

Setting: Anatomical theatre for cadaveric dissections; University Hospital for in vivo laparoscopy. Read More

J Pediatr Adolesc Gynecol 2019 Jan 29. Epub 2019 Jan 29.

Division of Gynecology, Department of Surgery, Boston Children's Hospital; Division of Minimally Invasive Surgery, Brigham & Women's Hospital; Boston Center for Endometriosis; Harvard Medical School, Boston, Massachusetts.

Background: Adolescent endometriosis typically presents as Stage I with superficial peritoneal disease [SPD] and less commonly as Stage III or IV with deeply infiltrative disease [DIE]. Endometriosis lesions can be destroyed (cautery or laser), cutting out the discrete lesion with excision and destroyed, or radically excised with removal of the lesion and surrounding tissue. It has been shown to be beneficial to excise DIE to improve pain. Read More

J Med Chem 2019 Feb 1. Epub 2019 Feb 1.

The presence and growth of endometrial tissue outside the uterine cavity in endometriosis patients is primarily driven by hormone-dependent and inflammatory processes - the latter being frequently associated with severe, acute and chronic pelvic pain. The EP4 subtype of prostaglandin E2 (PGE2) receptors (EP4-R) is a particularly promising anti-inflammatory and anti-nociceptive target as both this receptor subtype and the pathways forming PGE2 are highly expressed in endometriotic lesions. High-throughput screening resulted in the identification of benzimidazole derivatives as novel hEP4-R antagonists. Read More

J Reprod Infertil 2018 Oct-Dec;19(4):247-249

Department of Pathology, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Bowel endometriosis affects about 3.8-37% of women with endometriosis diagnosis. Most of the time endometriosis involves the recto-sigmoid. Read More

Gynecol Obstet Fertil Senol 2019 Jan 28. Epub 2019 Jan 28.

Centre de Recherche Saint Antoine UMRS_938, service de gynécologie, obstétrique, médecine de la reproduction, institut universitaire de cancérologie, Groupe Hospitalier AP-HP, 6 site Tenon, Sorbonne université, Plateforme de préservation de la fertilité, 4, rue de la Chine, 75020 Paris, France. Electronic address:

Objectives: To study the methods and strategies of fertility preservation in young women with stage I epithelial ovarian cancer (EOC), in order to provide recommendations for clinical practice.

Methods: The PubMed database was searched for english and french language articles, between 2005 and 2001, according to predefined search equations.

Results: Young patients with stage IA EOC willing to conceive should be informed that conservative treatment (contralateral ovary and salpinx, uterus) is possible (GradeC), associated with a 6 % to 13 % recurrence risk (GradeC) on the remaining ovary. Read More

Int J Dent Hyg 2019 Jan 31. Epub 2019 Jan 31.

Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Objective: Despite the importance of oral health during pregnancy and its consequences for mother and child, dental cleaning behavior is ineffective among pregnant women; therefore, the prevalence of gingivitis is high in this group. The aim of this study was to determine the factors affecting dental cleaning behavior among Iranian pregnant women with gingivitis.

Methods: This cross-sectional study was carried out in Sanandaj city, in the west of Iran in 2017. Read More