32,893 results match your criteria Endometrial Carcinoma


Anticancer and antimetastatic potential of enterolactone: clinical, preclinical and mechanistic perspectives.

Eur J Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Pharmaceutical Sciences, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra 411038, India.

Currently cancer is the second leading cause of death globally and worldwide incidence and mortality rates of all cancers of males and females are rising tremendously. In spite of advances in chemotherapy and radiation, metastasis and recurrence are considered as the major causes of cancer related deaths. Hence there is a mounting need to develop new therapeutic modalities to treat metastasis and recurrence in cancers. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.022DOI Listing
February 2019

CA 125 is a better marker to differentiate endometrial cancer and abnormal uterine bleeding.

Afr Health Sci 2018 Dec;18(4):972-978

Department of Obstetrics and Gynecology, Jawaharlal Institute of Post graduate Medical Education and Research, Puducherry - 605006.

Background: Incidence of endometrial cancer in India is increasing due to lifestyle changes and obesity. As 5 year survival rate of cancer confined to uterus is good, there is need for serum tumor marker for early diagnosis. This study was designed to identify a tumor marker which differentiate endometrial carcinoma and abnormal uterine bleeding (AUB) because common presentation of endometrial carcinoma is AUB. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354887PMC
December 2018

Oncogenic Y68 frame shift mutation of PTEN represents a mechanism of docetaxel resistance in endometrial cancer cell lines.

Sci Rep 2019 Feb 14;9(1):2111. Epub 2019 Feb 14.

NHC Key Laboratory of Radiobiology, Jilin University, Changchun, China.

In this study, we aimed to identify mutations of key genes associated with docetaxel resistance in nine endometrial cancer cell lines. Endometrial cancers are associated with several critical gene mutations, including PIK3A, PTEN, and KRAS. Different gene mutations in endometrial cancer cells have varied responses to anticancer drugs and cancer therapies. Read More

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http://dx.doi.org/10.1038/s41598-019-38585-9DOI Listing
February 2019

Sentinel lymph node mapping using indocyanine green in patients with uterine and cervical neoplasms: restrictions of the method.

Arch Gynecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiology, Institute of Mother and Child, Warsaw, Poland.

Purpose: To establish the surgical, demographic and histopathological factors associated with inaccurate sentinel lymph nodes (SLNs) identification using indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging in uterine and cervical neoplasms during both open and laparoscopic surgery.

Methods: We reviewed patients with atypical endometrial hyperplasia (AEH), clinical stage I and II cervical cancer or uterine malignancies who underwent primary surgery with SLN mapping between September 2015 and January 2018. An analysis of patients' demographics, tumor factors and surgical approach was conducted. Read More

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http://dx.doi.org/10.1007/s00404-019-05063-6DOI Listing
February 2019

Long Non-coding RNA CDKN2B Antisense RNA 1 Gene Contributes to Paclitaxel Resistance in Endometrial Carcinoma.

Front Oncol 2019 29;9:27. Epub 2019 Jan 29.

School of Health Sciences, Macao Polytechnic Institute, Macau, China.

Endometrial cancer (EC) is the most common malignancy of the female reproductive tract. In this study, we clarified the clinical significance of CDKN2B antisense RNA 1 (CDKN2B-AS) gene, and its effects on paclitaxel sensitivity in EC. Firstly, CDKN2B-AS gene was highly expressed in EC tissues and cell lines. Read More

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http://dx.doi.org/10.3389/fonc.2019.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361746PMC
January 2019

[S3 guidelines on the diagnosis and treatment of carcinoma of the endometrium : Requirements for pathology].

Pathologe 2019 Feb;40(1):21-35

Pathologisches Institut, Medizinische Fakultät, Ludwig-Maximilians-Universität München, München, Deutschland.

The present article summarises the relevant aspects of the S3 guidelines on endometrioid carcinomas. The recommendations include the processing rules of fractional currettings as well as for hysterectomy specimens and lymph node resections (including sentinel lymph nodes). Besides practical aspects, the guidelines consider the needs of the clinicians for appropriate surgical and radiotherapeutic treatment of the patients. Read More

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http://dx.doi.org/10.1007/s00292-019-0574-7DOI Listing
February 2019

A retrospective validation study of sentinel lymph node mapping for high-risk endometrial cancer.

Arch Gynecol Obstet 2019 Feb 12. Epub 2019 Feb 12.

Medical University of Tianjin, No. 22, Qixiangtai Road, Heping District, Tianjin, China.

Objectives: To determine the feasibility and performance of sentinel lymph-node (SLN) mapping among women with high-risk endometrial cancer (EC).

Materials And Methods: Ninety-eight patients at high-risk EC were enrolled in this retrospective surgical trial from August 2016 to August 2018. All patients underwent intraoperative SLN biopsy, with ICG injection for laparoscopic staging; this was followed by pelvic and paraaortic lymphadenectomy (LAD). Read More

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http://dx.doi.org/10.1007/s00404-019-05085-0DOI Listing
February 2019

Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers.

Thyroid 2019 Feb 12. Epub 2019 Feb 12.

The Ohio State University, Department of Cancer Biology and Genetics, Columbus, Ohio, United States ;

Background: Inactivation of DNA mismatch repair (MMR) and the resulting microsatellite instability (MSI) are frequently observed in endometrial, stomach and colorectal cancers as well as more rarely in other solid tumor types. The prevalence of MSI in thyroid cancer has not been explored in-depth, although recent studies utilizing data from large cancer sequencing efforts such as The Cancer Genome Atlas indicate MSI is absent or at least very rare in the most common and most well-studied histologic subtype, papillary carcinoma. In this study, we aim to determine the prevalence of MSI in thyroid cancer by using a large series comprising all major histological subtypes. Read More

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http://dx.doi.org/10.1089/thy.2018.0655DOI Listing
February 2019
4.493 Impact Factor

Impact of TP53 immunohistochemistry on the histological grading system for endometrial endometrioid carcinoma.

Mod Pathol 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan.

Endometrial endometrioid carcinoma is usually divided into three histological subgroups: grade 1 (G1), grade 2 (G2), and grade 3 (G3). Most cases of endometrial endometrioid carcinoma G1/2 have a favorable prognosis, although some can have unfavorable outcomes, especially when they involve elderly patients, with similarities to endometrioid carcinoma G3 and serous carcinoma. This retrospective study evaluated whether TP53 abnormalities in endometrial endometrioid carcinoma could be used to supplement the current grading system and improve its ability to predict clinical outcomes. Read More

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http://dx.doi.org/10.1038/s41379-019-0220-1DOI Listing
February 2019

Six months response rate of combined oral medroxyprogesterone/levonorgestrel-intrauterine system for early-stage endometrial cancer in young women: a Korean Gynecologic-Oncology Group Study.

J Gynecol Oncol 2019 Jan 7. Epub 2019 Jan 7.

Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.

Objective: To evaluate the efficacy of combined oral medroxyprogesterone acetate (MPA)/levonorgestrel-intrauterine system (LNG-IUS) treatment and to compare the diagnostic accuracy of endometrial aspiration biopsy with dilatation & curettage (D&C) in young women with early-stage endometrial cancer (EC) who wished to preserve their fertility.

Methods: A prospective phase II multicenter study was conducted from January 2012 to January 2017. Patients with grade 1 endometrioid adenocarcinoma confined to the endometrium were treated with combined oral MPA (500 mg/day)/LNG-IUS. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e47DOI Listing
January 2019
2 Reads
1.600 Impact Factor

Asian Society of Gynecologic Oncology International Workshop 2018.

J Gynecol Oncol 2019 Jan 14. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.

The Asian Society of Gynecologic Oncology International Workshop 2018 on gynecologic oncology was held in the Ajou University Hospital, Suwon, Korea on the 24th to 25th August 2018. The workshop was an opportunity for Asian doctors to discuss the latest findings of gynecologic cancer, including cervical, ovarian, and endometrial cancers, as well as the future of fertility-sparing treatments, minimally invasive/radical/debulking surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. Clinical guidelines and position statement of Asian countries were presented by experts. Read More

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https://ejgo.org/DOIx.php?id=10.3802/jgo.2019.30.e39
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http://dx.doi.org/10.3802/jgo.2019.30.e39DOI Listing
January 2019
2 Reads

Synchronous renal and para-aortic metastasis in a uterine serous carcinoma: A case review and clinical considerations.

Gynecol Oncol Rep 2019 May 28;28:12-14. Epub 2019 Jan 28.

Stony Brook University Hospital, United States.

•Serous endometrial carcinomas rarely involve the renal system.•Stage IVB serous endometrial carcinoma with confirmed renal metastasis.•Paclitaxel/carboplatin treating serous endometrial carcinoma with renal metastasis. Read More

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http://dx.doi.org/10.1016/j.gore.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357498PMC

Role of epithelial-mesenchymal transition factors in the histogenesis of uterine carcinomas.

Virchows Arch 2019 Feb 9. Epub 2019 Feb 9.

Department of Pathology, Hospices Civils de Lyon, Centre de Biologie et de Pathologie Sud, Chemin du Grand Revoyet, Université de Lyon, Université Claude Bernard Lyon I, 69495, Pierre Bénite Cedex, France.

Several subtypes of high-grade endometrial carcinomas (ECs) contain an undifferentiated component of non-epithelial morphology, including undifferentiated and dedifferentiated carcinomas and carcinosarcomas (CSs). The mechanism by which an EC undergoes dedifferentiation has been the subject of much debate. The epithelial-mesenchymal transition (EMT) is one of the mechanisms implicated in the transdifferentiation of high-grade carcinomas. Read More

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http://dx.doi.org/10.1007/s00428-019-02532-wDOI Listing
February 2019
1 Read

CeModule: an integrative framework for discovering regulatory patterns from genomic data in cancer.

BMC Bioinformatics 2019 Feb 7;20(1):67. Epub 2019 Feb 7.

College of Computer Science and Electronic Engineering, Hunan University, Changsha, 410082, China.

Background: Non-coding RNAs (ncRNAs) are emerging as key regulators and play critical roles in a wide range of tumorigenesis. Recent studies have suggested that long non-coding RNAs (lncRNAs) could interact with microRNAs (miRNAs) and indirectly regulate miRNA targets through competing interactions. Therefore, uncovering the competing endogenous RNA (ceRNA) regulatory mechanism of lncRNAs, miRNAs and mRNAs in post-transcriptional level will aid in deciphering the underlying pathogenesis of human polygenic diseases and may unveil new diagnostic and therapeutic opportunities. Read More

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http://dx.doi.org/10.1186/s12859-019-2654-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367773PMC
February 2019
3 Reads

Risk of malignancies among asymptomatic postmenopausal women with thickened endometrium: A cohort study.

Authors:
Zhe Li Lei Li

Medicine (Baltimore) 2019 Feb;98(6):e14464

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital.

The risk of malignancies and related factors among asymptomatic postmenopausal women with thickened endometrium in transvaginal sonography (TVS) are unclear.In this longitudinal study at a tertiary teaching hospital, all medical records of hysteroscopy were searched and retrospectively reviewed according to age, TVS results and diseases coded as International Classification of Diseases version 10. Asymptomatic postmenopausal women with endometrial thickness ≥5 mm from January 2006 to January 2016 were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000014464DOI Listing
February 2019
1 Read
5.723 Impact Factor

Could E-Cadherin and CD10 Expression be Used to Differentiate Between Atypical Endometrial Hyperplasia and Endometrial Carcinoma?

Int J Gynecol Pathol 2019 Mar;38(2):128-137

Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Endometrial carcinoma contributes to morbidity and mortality among female individuals worldwide. The role of E-cadherin expression, as an adhesion molecule, in endometrial carcinoma is controversial. Moreover, the role of CD10-expressing stromal cells in endometrial carcinoma is still unclear. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000492DOI Listing
March 2019
1 Read

Rapid progression of disease in two cases of undifferentiated endometrial carcinoma.

Gynecol Oncol Rep 2019 Feb 18;27:65-68. Epub 2019 Jan 18.

University of California Irvine Medical Center, Orange, CA 92868, United States.

Undifferentiated endometrial carcinoma, a rare histopathologic diagnosis, has a poor prognosis with high risk of progression during or shortly after completion of adjuvant treatment. We present two cases of undifferentiated endometrial carcinoma: one in a postmenopausal female who experienced recurrent disease immediately after completion of adjuvant treatment and one in a premenopausal female who experienced disease progression while receiving adjuvant treatment. These cases exemplify the aggressive behavior of undifferentiated endometrial carcinoma and suggest the need for a more effective treatment in the upfront setting than the current standard of care for endometrioid endometrial adenocarcinoma. Read More

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http://dx.doi.org/10.1016/j.gore.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351352PMC
February 2019

A case of an endobronchial metastasis from an endometrial carcinoma.

SAGE Open Med Case Rep 2019 16;7:2050313X18823901. Epub 2019 Jan 16.

Department of Pathology, School of Medicine, Dongsan Medical Center, Keimyung University, Daegu, Korea.

A 73-year-old woman was referred to the pulmonology department for abnormal findings on chest computed tomography. She had undergone a laparoscopic staging operation including a hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvic node and para-aortic node dissection, and concurrent chemo-radiation therapy for endometrial serous carcinoma stage IIIc cancer 15 months earlier. A follow-up chest computed tomography after the chemotherapy showed that the right lower lobe bronchus was obstructed, and it was necessary to differentiate a primary lung malignancy from a metastasis and secretion. Read More

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http://dx.doi.org/10.1177/2050313X18823901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349978PMC
January 2019
1 Read

Endometrial Carcinoma Follow-up: Time for a Change?

Clin Oncol (R Coll Radiol) 2019 Feb 1. Epub 2019 Feb 1.

St Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, UK.

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http://dx.doi.org/10.1016/j.clon.2019.01.007DOI Listing
February 2019

Six-transmembrane epithelial antigen of the prostate 1 is associated with tumor invasion and migration in endometrial carcinomas.

J Cell Biochem 2019 Feb 3. Epub 2019 Feb 3.

Department of Maternal and Child Health, School of Public Health, Shandong University, Jinan, China.

Six-transmembrane epithelial antigen of the prostate 1 (STEAP1), a member of the STEAP family, is a general tumor antigen. However, no information has been available to date regarding the function of STEAP1 in the progression of endometrial carcinoma. In this study, we used in vitro and in vivo strategies to prove that STEAP1 plays an important role in the progression of endometrial carcinoma. Read More

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http://dx.doi.org/10.1002/jcb.28393DOI Listing
February 2019
1 Read

A Case of Spontaneous Regression of Recurrent Undifferentiated Carcinoma of the Endometrium.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Japanese Red Cross Ishinomaki Hospital, Japan.

We herein report a very rare case of spontaneous regression of recurrent undifferentiated carcinoma of the endometrium. An 80-year-old woman had undergone total hysterectomy with bilateral adnexectomy for undifferentiated carcinoma of the endometrium. The cancer recurred locally 10 months after surgery and then metastasized to the lung and liver. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.0376-17DOI Listing
February 2019
3 Reads

Targeted sequencing with a customized panel to assess histological typing in endometrial carcinoma.

Virchows Arch 2019 Feb 1. Epub 2019 Feb 1.

Hospital Universitari Arnau de Vilanova, Universitat de Lleida, IRBLLEIDA, CIBERONC, Lleida, Spain.

The two most frequent types of endometrial cancer (EC) are endometrioid (EEC) and serous carcinomas (SC). Differential diagnosis between them is not always easy. A subset of endometrial cancers shows misleading microscopical features, which cause problems in differential diagnosis, and may be a good scenario for next-generation sequencing. Read More

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http://dx.doi.org/10.1007/s00428-018-02516-2DOI Listing
February 2019

Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.

Surg Pathol Clin 2019 Mar 24;12(1):107-137. Epub 2018 Dec 24.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Mesenchymal tumors of the uterus comprise a heterogeneous group of neoplasms of varied biologic potential. In addition to being host to several anatomically unique entities, the uterus may contain mesenchymal neoplasms typically found elsewhere in the body. Although smooth muscle neoplasms are common, other mesenchymal neoplasms in this location are relatively rare. Read More

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http://dx.doi.org/10.1016/j.path.2018.10.005DOI Listing
March 2019
1 Read

[Precursor lesions of endometrial carcinoma].

Authors:
S F Lax

Pathologe 2019 Feb;40(1):13-20

Institut für Klinische Pathologie und Molekularpathologie, LKH Graz II, Standort West, Akademisches Lehrkrankenhaus der Medizinischen Universität Graz, Göstinger Straße 22, 8020, Graz, Österreich.

The 2014 WHO classification distinguishes between endometrial hyperplasia without atypia (EH) and atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia (AEH/EIN). AEH/EIN is characterized by crowded glands with cytologically atypical epithelium separated by little intervening stroma. Cellular atypia is characterized by nuclear enlargement and rounding, pleomorphism, loss of polarity, and presence of nucleoli. Read More

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http://dx.doi.org/10.1007/s00292-019-0568-5DOI Listing
February 2019

Tumor budding in laryngeal carcinoma.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):7-10

Department of Head and Neck Surgery, Health Sciences University, Tepecik Training and Research Hospital, Izmir, Turkey.

Background: Tumor budding was defined as a single cancer cell or a cluster of fewer than five cancer cells in the stroma of the invasive tumor margin. It has been suggested as a prognostic factor in various cancers, such as esophageal, lung, colorectal, and endometrial. There are only a few studies about the prognostic signifi cance of tumor budding in laryngeal carcinomas. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_428_17DOI Listing
February 2019

Cytological features of uterine carcinosarcoma: A retrospective study of 20 cases with an emphasis on the usefulness of endometrial cytology.

Diagn Cytopathol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan.

Background: Carcinosarcoma of the endometrium is a relatively rare but aggressive neoplasm. Endometrial cytological features of this type of tumor have been rarely reported. This study aimed to clarify the usefulness of endometrial cytological examination in the diagnosis of endometrial carcinosarcoma. Read More

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http://dx.doi.org/10.1002/dc.24152DOI Listing
February 2019

Relationship between Hypothyroidism and Endometrial Cancer.

Aging Dis 2019 Feb 1;10(1):190-196. Epub 2019 Feb 1.

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.

Thyroid dysfunction is involved in several types of carcinoma. Hypothyroidism is one of the most common medical morbidities among patients with endometrial cancer; however, the related mechanism is unclear. Among the risk factors related to endometrial cancer, hypothyroidism interacts with metabolic syndrome, polycystic ovarian syndrome and infertility or directly acts on the endometrium itself, which may influence the development and progression of endometrial cancer. Read More

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http://dx.doi.org/10.14336/AD.2018.0224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345335PMC
February 2019
1 Read

Expression of NR1H3 in endometrial carcinoma and its effect on the proliferation of Ishikawa cells in vitro.

Onco Targets Ther 2019 18;12:685-697. Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China,

Purpose: Our study aimed to investigate the expression of NR1H3 in endometrial carcinoma, its effect on the proliferation of endometrial carcinoma cells in vitro, and the underlying mechanism of this effect.

Materials And Methods: Immunohistochemistry of paraffin-embedded, sectioned specimens and of a tissue microarray was conducted to estimate the expression of NR1H3 (liver X receptors α: LXRα) and NR1H2 (liver X receptors β: LXRβ) in endometrial carcinoma tissues. The subcellular localization of NR1H3 in the endometrial carcinoma cell line Ishikawa was determined by immunofluorescence. Read More

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http://dx.doi.org/10.2147/OTT.S180534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343513PMC
January 2019
2 Reads

Clinicopathologic and Immunohistochemical Correlates of CTNNB1 Mutated Endometrial Endometrioid Carcinoma.

Int J Gynecol Pathol 2019 Jan 29. Epub 2019 Jan 29.

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

Endometrial endometrioid carcinomas (EECs) with exon 3 CTNNB1 mutations characterize a more aggressive subset of tumors in patients with low-grade low-stage disease. Thus, prospectively identifying these cases may be clinically relevant. The aim of this study was to examine the feasibility of β-catenin and Cyclin D1 immunohistochemistry to identify EECs harboring CTNNB1 mutations and to evaluate the clinicopathologic features of EECs with exon 3 CTNNB1 mutations. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000583DOI Listing
January 2019
1 Read

Comparison and analysis of the clinicopathological features of SCEO and ECOM.

J Ovarian Res 2019 Jan 30;12(1):10. Epub 2019 Jan 30.

Department of Gynecology, obstetrics and gynecology hospital, Fudan university, Shanghai, 200,090, China.

Objective: The aim of our study was to evaluate and compare the differences in the clinicopathological variables and overall survival (OS) of synchronous primary cancers of the endometrium and ovary (SCEO) and endometrial cancer with ovarian metastasis (ECOM). In addition, we aimed to determine the characteristics of and effective treatments for patients with SCEO to avoid misdiagnosis and overtreatment.

Materials And Methods: A review of medical records from January 2009 to January 2017 revealed 111 patients with coexisting ovarian and endometrial carcinoma diagnosed at the Obstetrics and Gynecology Hospital of Fudan University. Read More

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http://dx.doi.org/10.1186/s13048-019-0485-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352368PMC
January 2019
1 Read

Abundance of mitochondrial superoxide dismutase is a negative predictive biomarker for endometriosis-associated ovarian cancers.

World J Surg Oncol 2019 Jan 30;17(1):24. Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, Shiga University of Medical Science, SetaTsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

Background: Endometrioid ovarian carcinoma and clear cell ovarian carcinoma are both classified as endometriosis-associated ovarian cancers (EAOCs). Despite the high rates of recurrence and mortality of EAOC, only a few prognostic biomarkers have been reported. Mitochondrial superoxide dismutase (SOD2) plays an important role in maintaining mitochondrial function through oxidative stress tolerance and contributes to chemotherapeutic resistance. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-019-1
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http://dx.doi.org/10.1186/s12957-019-1565-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354361PMC
January 2019
2 Reads

X chromosome-linked long noncoding RNA lnc-XLEC1 regulates c-Myc-dependent cell growth by collaborating with MBP-1 in endometrial cancer.

Int J Cancer 2019 Jan 30. Epub 2019 Jan 30.

Department of Genetics, Medical College of Soochow University, Suzhou 215123, China.

LncRNAs (long noncoding RNAs) are noncoding transcripts that are more than 200 nt long and have been described as the largest subclass in the noncoding transcriptome in humans. Although studies of lncRNAs in cancer have been continuing for a long time, no much has been known about X chromosome-linked lncRNAs. Here, by using RNA-seq we report the identification of a new X chromosome-linked lncRNA (lnc-XLEC1) that is aberrantly downregulated during the development of endometrial carcinoma (EC). Read More

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http://dx.doi.org/10.1002/ijc.32166DOI Listing
January 2019
1 Read
5.085 Impact Factor

Efficacy and safety of ospemifene in postmenopausal women with moderate-to-severe vaginal dryness: a phase 3, randomized, double-blind, placebo-controlled, multicenter trial.

Menopause 2019 Jan 28. Epub 2019 Jan 28.

Duchesnay Inc, Quebec, Canada.

Objective: To evaluate the safety and efficacy of ospemifene for the treatment of moderate to severe vaginal dryness in postmenopausal women with vulvovaginal atrophy (VVA).

Methods: This 12-week, multicenter, double-blind phase 3 study randomized postmenopausal women (aged 40-80 years) with VVA and moderate to severe vaginal dryness as their most bothersome symptom to daily oral ospemifene 60 mg or placebo. Coprimary efficacy endpoints included changes from baseline to week 12 in percentages of vaginal parabasal and superficial cells, vaginal pH, and vaginal dryness severity with ospemifene versus placebo; other secondary endpoints were evaluated (weeks 4, 8, and 12). Read More

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http://dx.doi.org/10.1097/GME.0000000000001292DOI Listing
January 2019
1 Read

Diagnostic accuracy of saline contrast sonohysterography to detect endometrial polyps in women with postmenopausal bleeding: a systematic review and meta-analysis.

Ultrasound Obstet Gynecol 2019 Jan 28. Epub 2019 Jan 28.

Department of Obstetrics and Gynecology; Maastricht UMC+, Maastricht, GROW- School for Oncology and Developmental Biology.

Introduction: Postmenopausal bleeding is a common complaint and is related to several benign and malignant conditions. Frequent findings in women with postmenopausal bleeding are endometrial polyps. The risk of a focal (pre)malignancy in a polyp in women with postmenopausal bleeding is up to 6%. Read More

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http://dx.doi.org/10.1002/uog.20229DOI Listing
January 2019
1 Read

Clinicopathological analysis of clinically occult extrapulmonary lymphangioleiomyomatosis in intra-pelvic and para-aortic lymph nodes associated with pelvic malignant tumors: A study of nine patients.

Pathol Int 2019 Jan;69(1):29-36

Department of Pathology, Kobe City Medical Center General Hospital, Kobe, Japan.

The clinicopathological and immunohistochemical characteristics of clinically occult extrapulmonary lymphangioleiomyomatosis in lymph nodes (LN-LAM) being dissected during surgical staging of pelvic malignancy have not been well investigated. We assessed samples from nine female patients (median age, 61). None had past or familial history of tuberous sclerosis and had LAM lesions other than LN such as lung. Read More

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http://dx.doi.org/10.1111/pin.12749DOI Listing
January 2019
1 Read

A Phase 2 Study to Assess the Immunomodulatory Capacity of a Lecithin-based Delivery System of Curcumin in Endometrial Cancer.

Front Nutr 2018 11;5:138. Epub 2019 Jan 11.

Laboratory of Gynaecologic Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.

Curcumin is a botanical with anti-tumor and immunomodulatory properties. We hypothesized that curcumin supplementation might influence inflammatory biomarker levels in endometrial carcinoma (EC). In this open-label, non-randomized phase 2 study (NCT02017353), seven EC patients consumed 2 g/day Curcumin Phytosome (CP) orally for 2 weeks. Read More

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https://www.frontiersin.org/article/10.3389/fnut.2018.00138/
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http://dx.doi.org/10.3389/fnut.2018.00138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336921PMC
January 2019
1 Read

RRBP1 overexpression is associated with progression and prognosis in endometrial endometrioid adenocarcinoma.

Diagn Pathol 2019 Jan 26;14(1). Epub 2019 Jan 26.

Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, 150081, China.

Background: Currently, ribosome-binding protein 1 (RRBP1) is considered to be a novel oncogene that is overexpressed in colorectal cancer, lung cancer, mammary cancer, esophageal cancer and other carcinomas. However, the relationship between RRBP1 and endometrioid-type endometrial carcinoma (EC) remains unknown. Our purpose is to explore the function of RRBP1 in endometrioid-type endometrial carcinoma. Read More

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http://dx.doi.org/10.1186/s13000-019-0784-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347782PMC
January 2019
2 Reads

Expression and potential role of SNF5 in endometrial carcinoma.

BMC Womens Health 2019 Jan 25;19(1):16. Epub 2019 Jan 25.

Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, 110122, Liaoning, China.

Background: SNF5 is a key protein in regulating cell proliferation and apoptosis in various cancers. However, the physiological roles of SNF5 in Endometrial carcinoma (EC), which is one of the most frequent malignancies of the female reproduction worldwide, remains unclear. This study aims to investigate the role of SNF5 and its correlation with clinicopathologic characteristics in EC. Read More

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https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12905-019-0718-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346509PMC
January 2019
2 Reads

Current progress in the inflammatory background of angiogenesis in gynecological cancers.

Inflamm Res 2019 Jan 24. Epub 2019 Jan 24.

Chair and Department of General and Experimental Pathology, Medical University of Warsaw, ul. Pawinskiego 3C, 02-106, Warsaw, Poland.

A tumor growth depends on the potency of the tumor to support itself with nutrients and oxygen. The development of a vascular network within the tumor is key to its survival. The permanent contest between the tumor and its host involves tumor cells on one side and an immunological system and tissue stroma on the other. Read More

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http://dx.doi.org/10.1007/s00011-019-01215-1DOI Listing
January 2019

Occurrence, toxicity and transformation of six typical benzotriazoles in the environment: A review.

Sci Total Environ 2019 Apr 17;661:407-421. Epub 2019 Jan 17.

The Environmental Research Institute, MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China.

Benzotriazoles (BTs) are a group of heterocyclic compounds which have been widely applied in industrial activities and domestic life mainly as corrosive inhibitors. BTs have been ubiquitously detected in receiving environments and cause potential toxicity to non-target organisms. This paper reviews the occurrence and fate of six selected benzotriazole compounds in different environmental and biological matrices, as well as the transformation and toxicity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193015
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http://dx.doi.org/10.1016/j.scitotenv.2019.01.138DOI Listing
April 2019
8 Reads

Endometrial Endometrioid Carcinoma With Ovarian Metastasis Showing Morula-like Features in a Patient With Cowden Syndrome: A Case Report.

Int J Gynecol Pathol 2019 Jan 22. Epub 2019 Jan 22.

Departments of Gynecology (I.K., K.Tate, K. Takahashi, T.K.) Pathology and Clinical Laboratories (H.Y.), National Cancer Center Hospital, Tokyo, Japan.

Cowden syndrome (CS) is a multiple hamartoma syndrome associated with the development of various tumors, including endometrial cancer. However, the histology of CS-associated endometrial cancer remains to be fully described. To our knowledge, this is the first report of a patient with CS having endometrial endometrioid carcinoma with ovarian metastasis demonstrating morula-like features. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000576DOI Listing
January 2019
3 Reads

Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico-pathological and molecular (next generation sequencing) study of 22 cases.

Oncol Lett 2019 Feb 20;17(2):2207-2214. Epub 2018 Dec 20.

Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12800 Prague, Czech Republic.

The criteria for distinction between independent primary tumors and metastasis from one site to the other in synchronous endometrioid endometrial and ovarian carcinoma (SEO) has been a matter of dispute for a long time. In our study we performed a comprehensive clinico-pathological and molecular analysis of 22 cases of SEO. Based on conventional clinico-pathological criteria the cases were classified as independent primary tumors (10 cases) and metastasis from one location to the other (12 cases). Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9855
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http://dx.doi.org/10.3892/ol.2018.9855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341770PMC
February 2019
3 Reads

Treatment efficiency of comprehensive hysteroscopic evaluation and lesion resection combined with progestin therapy in young women with endometrial atypical hyperplasia and endometrial cancer.

Gynecol Oncol 2019 Jan 21. Epub 2019 Jan 21.

Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China. Electronic address:

Objective: This study aimed to evaluate the efficacy of comprehensive hysteroscopic evaluation and lesion resection combined with progestin therapy in young patients with endometrial atypical hyperplasia (EAH) and early stage endometrial cancer (EEC) who wished to preserve their fertility.

Methods: Patients with EAH (n = 120) or well-differentiated EEC (n = 40, FIGO stage IA, without myometrial invasion) were retrospectively included. All patients received constant oral progestin combined with hysteroscopic evaluation every 3 months until achieving complete response (CR). Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.01.014DOI Listing
January 2019
1 Read

The prevalence of germline DICER1 pathogenic variation in cancer populations.

Mol Genet Genomic Med 2019 Jan 22:e555. Epub 2019 Jan 22.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland.

Background: The DICER1 syndrome is an autosomal dominant tumor-predisposition disorder associated with pleuropulmonary blastoma, a rare pediatric lung cancer. Somatic missense variation in "hotspot" codons in the RNaseIIIb domain (E1705, D1709, G1809, D1810, E1813) is observed in DICER1-associated tumors. Previously, we found the prevalence of germline pathogenic DICER1 variation in the general population is 1:10,600. Read More

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http://dx.doi.org/10.1002/mgg3.555DOI Listing
January 2019
11 Reads

RE: prognostic factors and genes associated with endometrial cancer based on gene expression profiling and bioinformatics analysis.

Arch Gynecol Obstet 2019 Jan 22. Epub 2019 Jan 22.

Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, Republic of Korea.

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http://dx.doi.org/10.1007/s00404-019-05049-4DOI Listing
January 2019

Long Noncoding RNA (lncRNA) MIR22HG Suppresses Gastric Cancer Progression through Attenuating NOTCH2 Signaling.

Authors:
Huihui Li Yue Wang

Med Sci Monit 2019 Jan 23;25:656-665. Epub 2019 Jan 23.

Department of Pharmacology and Toxicology, Wright State University, Fairborn, OH, USA.

BACKGROUND Long noncoding RNAs (lncRNAs) are important regulators in human disease, including cancers. LncRNA MIR22HG has been shown to inhibit the progression of endometrial carcinoma, lung cancer, and hepatocellular carcinoma. Its role in gastric cancer is unclear. Read More

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https://www.medscimonit.com/abstract/index/idArt/912813
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http://dx.doi.org/10.12659/MSM.912813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352764PMC
January 2019
3 Reads

TNM classification of gynaecological malignant tumours, eighth edition: changes between the seventh and eighth editions.

Jpn J Clin Oncol 2019 Jan 22. Epub 2019 Jan 22.

Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.

The staging classification of gynaecological malignancies has been revised by the International Federation of Gynecology and Obstetrics (FIGO) and has been subsequently reviewed by the FIGO Committee on Gynecologic Oncology, the International Union for Cancer Control TNM Committee and the American Joint Committee on Cancer. The major change in the eighth edition of TNM classification of gynaecological malignant tumours is integrated staging for ovarian, fallopian tube and primary peritoneal carcinoma, whereas the seventh edition distinguished 'ovary and primary peritoneal carcinoma' and 'Fallopian tube carcinoma'. Furthermore, the new edition describes a prognostic factor grid for vulvar, cervical, endometrial and ovarian, fallopian tube and primary peritoneal carcinoma. Read More

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http://dx.doi.org/10.1093/jjco/hyy206DOI Listing
January 2019
1 Read

Two-sided role of estrogen on endometrial carcinogenesis: stimulator or suppressor?

Gynecol Endocrinol 2019 Jan 22:1-6. Epub 2019 Jan 22.

a Department of Obstetrics and Gynecology , Shinshu University School of Medicine , Matsumoto , Japan.

Endometrial carcinoma (EC) often expresses estrogen receptors (ER), and the growth of EC is stimulated by estrogen. Therefore, EC is considered to be an estrogen-dependent tumor. However, the role of estrogen in endometrial carcinogenesis is somewhat unclear because the majority of EC occurs at peri- or post menopause when serum estrogen levels are generally decreased. Read More

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https://www.tandfonline.com/doi/full/10.1080/09513590.2018.1
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http://dx.doi.org/10.1080/09513590.2018.1549219DOI Listing
January 2019
2 Reads

Abnormal hysteroscopy findings among a cross section of infertile Nigerian women.

Niger J Clin Pract 2019 Jan;22(1):9-15

Department of Obstetrics and Gynaecology, University of Portharcout Teaching Hospital, Port Harcourt, Nigeria.

Background: Intrauterine lesions are important causes of infertility. This study aims to evaluate the abnormal findings at hysteroscopy among infertile women seen in 2 new Fertility/Gynaecological Endoscopy units in Nigeria.

Methods: A prospective study of 159 infertile women who had diagnostic hysteroscopy in Nnamdi Azikiwe University Teaching hospital Nnewi and Holy Rosary Specialist Hospital, Onitsha to evaluate the intrauterine lesions seen. Read More

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http://dx.doi.org/10.4103/njcp.njcp_404_17DOI Listing
January 2019
5 Reads

Prognostic significance of lymphovascular space invasion in low-risk endometrial cancer.

Int J Gynecol Cancer 2019 Jan 21. Epub 2019 Jan 21.

Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Turkey.

Objective: The purpose of this study was to assess the prognostic significance of lymphovascular space invasion in women with low-risk endometrial cancer.

Methods: A dual-institutional, retrospective department database review was performed to identify patients with 'low-risk endometrial cancer' (patients having <50% myometrial invasion with grade 1 or 2 endometrioid endometrial cancer according to their final pathology reports) at two gynecologic oncology centers in Ankara, Turkey. Demographic, clinicopathological and survival data were collected. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000069DOI Listing
January 2019