58,043 results match your criteria Endometrial Carcinoma


Impairment of the antifibrotic prostaglandin E pathway may influence neutrophil extracellular traps-induced fibrosis in the mare endometrium.

Domest Anim Endocrinol 2018 Nov 3;67:1-10. Epub 2018 Nov 3.

Department of Morphology and Function, CIISA- Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

Prostaglandin E (PGE) has contradictory effects in many organs. It may have proinflammatory, anti-inflammatory, or anti-fibrotic roles, depending on the type of receptors to which it binds. By signaling through its receptors EP2 and EP4, PGE mediates anti-inflammatory and anti-fibrotic actions. Read More

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November 2018
2 Reads

Extent of Lymphadenectomy and Postoperative Major Complications Among Women with Endometrial Cancer Treated with Minimally Invasive Surgery.

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

Northwestern University, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Chicago, IL, USA; Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL; Center for Healthcare Studies, Institute for Public Health in Medicine, Chicago, IL.

Background: In patients with endometrial cancer sentinel lymphadenectomy is used to accurately prognosticate extent of disease and has been proposed as a method to decrease the incidence of medical and surgical complications associated with more extensive lymphadenectomy. It is unknown if patients who undergo traditional lymphadenectomy experience major postoperative complications at the same rates as those who undergo sentinel lymphadenectomy or those who do not undergo lymphadenectomy.

Objective: To compare the incidence of major postoperative complications among endometrial cancer patients undergoing total laparoscopic hysterectomy with traditional lymphadenectomy versus sentinel or no lymphadenectomy. Read More

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December 2018
2 Reads

Hysteroscopy for treating subfertility associated with suspected major uterine cavity abnormalities.

Cochrane Database Syst Rev 2018 Dec 5;12:CD009461. Epub 2018 Dec 5.

Academic Centre for General Practice, Cochrane Belgium, Kapucijnenvoer 33, blok J bus 7001, Leuven, Belgium, 3000.

Background: Observational studies suggest higher pregnancy rates after the hysteroscopic removal of endometrial polyps, submucous fibroids, uterine septum or intrauterine adhesions, which are present in 10% to 15% of women seeking treatment for subfertility.

Objectives: To assess the effects of the hysteroscopic removal of endometrial polyps, submucous fibroids, uterine septum or intrauterine adhesions suspected on ultrasound, hysterosalpingography, diagnostic hysteroscopy or any combination of these methods in women with otherwise unexplained subfertility or prior to intrauterine insemination (IUI), in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI).

Search Methods: We searched the following databases from their inception to 16 April 2018; The Cochrane Gynaecology and Fertility Group Specialised Register, the Cochrane Central Register of Studies Online, ; MEDLINE, Embase , CINAHL , and other electronic sources of trials including trial registers, sources of unpublished literature, and reference lists. Read More

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December 2018
1 Read

Oral and intrauterine progestogens for atypical endometrial hyperplasia.

Cochrane Database Syst Rev 2018 Dec 4;12:CD009458. Epub 2018 Dec 4.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, Section Three, Ren Min Nan Lu Avenue, Chengdu, Sichuan, China, 610041.

Background: Endometrial carcinoma is the most common gynaecologic malignancy in the world and develops through preliminary stages of endometrial hyperplasia. Atypical endometrial hyperplasia suggests a significant pre-malignant state with frank progression to endometrial carcinoma, and tends to occur at a young age. Oral progestins have been used as conservative treatment in young women with atypical endometrial hyperplasia, but they are associated with poor tolerability and side effects that may limit their overall efficacy. Read More

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December 2018
3 Reads

Mismatch repair deficiency and aberrations in the Notch and Hedgehog pathways are of prognostic value in patients with endometrial cancer.

PLoS One 2018 6;13(12):e0208221. Epub 2018 Dec 6.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

The aim of this study was to investigate the prognostic value of the Hedgehog (Gli, Patched-1, Shh, Smo) and Notch (Jag1, Notch2, Notch3) pathway members, in comparison to a panel of proteins (ER, PgR, HER2/neu, Ki67, p53, p16, PTEN and MMR) previously suggested to be involved in the pathogenesis of endometrial cancer, in association with clinical outcome and standard clinicopathological characteristics. A total of 204 patients with histological diagnosis of endometrial cancer treated from 2004 to 2013 were included. The evaluation of protein expression was assessed by immunohistochemistry. Read More

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December 2018
1 Read

My Womban's Life: Understanding Human Endometrial Function.

Authors:
Lois Salamonsen

Reproduction 2018 Dec 1. Epub 2018 Dec 1.

L Salamonsen, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Australia.

The focus of my life in science, has been to improve reproductive health for women, with an emphasis on the endometrium, the most dynamic tissue in the human body: its remarkable cyclical remodelling is essential for establishment of pregnancy. The most notable events in a woman's endometrial cycle are menstruation and endometrial repair, regeneration of the endometrium during the proliferative phase, attainment of receptivity by the mid-secretory phase of the cycle and the embryo-maternal interactions that initiate peri-implantation events within the microenvironment of the uterine cavity. I have contributed to understanding the molecular and cellular changes underpinning these events, and how disturbance of them leads to menstrual disorders, infertility and endometrial diseases including abnormal uterine bleeding, endometriosis and endometrial cancer. Read More

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December 2018

Robotic surgery in the management of complex pelvic endometriosis.

Int Braz J Urol 2018 Oct 20;44. Epub 2018 Oct 20.

Department of Urology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Introduction: Endometriosis consists in the proliferation of endometrial tissue outside of the uterine cavity, predominantly in the ovaries but also in the urinary bladder or bowel. About 10% of fertile women are affected and the main symptoms are pain, menstrual disorders and infertility. Surgery is the treatment option for those symptomatic patients in which medical treatment had no success. Read More

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October 2018
1 Read

An update and systematic review on the treatment of primary dysmenorrhea.

JBRA Assist Reprod 2018 Dec 6. Epub 2018 Dec 6.

Nursing Research Center, Golestan University of Medical Sciences, Gorgan, IR Iran.

Objectives: Primary dysmenorrhea is a painful uterine contraction caused by endometrial laceration. Drug therapies and complementary medicine have been used to treat dysmenorrhea. The aim of this study was to investigate and offer an updated perspective on the treatments for dysmenorrhea. Read More

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December 2018
1 Read

Transdermal versus oral estrogen: clinical outcomes in patients undergoing frozen-thawed single blastocyst transfer cycles without GnRHa suppression, a prospective randomized clinical trial.

J Assist Reprod Genet 2018 Dec 5. Epub 2018 Dec 5.

Assisted Reproductive Technologies and Reproductive Genetics Centre, Istanbul Memorial Hospital, Piyale Pasa Bulvari, 34385, Okmeydani, Istanbul, Turkey.

Purpose: To conduct a non-inferiority study to compare the clinical outcomes of transdermal estrogen patch and oral estrogen in patients undergoing frozen-thawed single blastocyst transfer non-donor cycles without GnRHagonist (GnRHa) suppression.

Methods: A total of 317 women with irregular menses or anovulatory cycle undergoing frozen-thawed embryo transfer (FET) non-donor cycles without GnRHa suppression were involved in a prospective randomized clinical trial between May 2017 and October 2017. The trial was conducted in an ART and Reproductive Genetics Centre within a private hospital. Read More

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December 2018
1 Read

Malignant transformation of adenomyosis: literature review and meta-analysis.

Arch Gynecol Obstet 2018 Dec 5. Epub 2018 Dec 5.

Department of Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong Province, China.

Purpose: To review and analyze risk factors and the pathology of malignant transformation of adenomyosis.

Methods: In this paper, the relevant research on current risks factors and the pathology of malignant transformation of adenomyosis was reviewed and analyzed by metaanalysis. All studies included were retrieved from the PUBMED. Read More

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December 2018

The incidence and predictors of gynecologic malignancies among postmenopausal patients with endometrial fluid collection.

Authors:
Zhe Li Lei Li

Arch Gynecol Obstet 2018 Dec 5. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No 1, Dongcheng District, Beijing, China.

Objective: To investigate the incidence and predictors of gynecologic malignancies among postmenopausal patients with endometrial fluid collection (EFC).

Methods: All patients with EFC diagnosed by transvaginal sonography (TVS) were retrospectively reviewed if they had undergone biopsy of the endometrium from January 2008 to January 2016 in a tertiary teaching hospital. Follow-up ended in June 2017. Read More

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December 2018

Age at First Birth and the Risk of Endometrial Cancer Incidence: A Pooled Analysis of Two Prospective Cohort Studies among Japanese Women.

J Cancer 2018 27;9(23):4422-4429. Epub 2018 Oct 27.

Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.

Age at first birth has been increasing among women in developed countries. Meanwhile, endometrial cancer has also been increasing worldwide, being one of the most common female hormone-related cancers. The purpose of this study was to examine the association between age at first birth and the risk of endometrial cancer among Japanese women, and to examine the hypothesis that the recent increase in endometrial cancer incidence can be partly explained by the trend for increasing age at first birth. Read More

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October 2018
1 Read

A two-step strategy for identification of plasma protein biomarkers for endometrial and ovarian cancer.

Clin Proteomics 2018 1;15:38. Epub 2018 Dec 1.

1Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory (SciLifeLab) Uppsala, Uppsala University, Box 815, 75108 Uppsala, Sweden.

Background: Over 500,000 women worldwide are diagnosed with ovarian or endometrial cancer each year. We have used a two-step strategy to identify plasma proteins that could be used to improve the diagnosis of women with an indication of gynecologic tumor and in population screening.

Methods: In the discovery step we screened 441 proteins in plasma using the proximity extension assay (PEA) and five Olink Multiplex assays (CVD II, CVD III, INF I, ONC II, NEU I) in women with ovarian cancer (n = 106), endometrial cancer (n = 74), benign ovarian tumors (n = 150) and healthy population controls (n = 399). Read More

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December 2018

T cell dysfunction in chronic hepatitis B infection and liver cancer: evidence from transcriptome analysis.

J Med Genet 2018 Dec 5. Epub 2018 Dec 5.

Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.

Background: T cell dysfunction occurs in many diseases, especially in chronic virus infection and cancers. However, up to now, little is known on the distinctions in T cell exhaustion between cancer and chronic virus infection. The objective of this study is to explore the transcriptional similarities and differences in exhausted CD8 +T cell between chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Read More

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December 2018

Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions.

Reprod Biol Endocrinol 2018 Dec 5;16(1):121. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat Gan, Israel.

Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age and embryo stage into consideration. The failure of embryo implantation can be a consequence of uterine, male, or embryo factors, or the specific type of IVF protocol. Read More

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December 2018

Efficient treatment of chronic endometritis through a novel approach of intrauterine antibiotic infusion: a case series.

BMC Womens Health 2018 Dec 5;18(1):197. Epub 2018 Dec 5.

Centre for Human Reproduction, Genesis Athens Clinic, 14-16, Papanikoli 15232, Athens, Greece.

Background: Early diagnosis and efficient management of Chronic Endometritis (CE) in patients seeking fertility treatment are two components every practitioner wishes to address. With respect to endometrial restoration, antibiotic treatment appears to perform well. However, regarding the improvement of In Vitro Fertilization (IVF) success rates, literature evidence is inconclusive, and consensus on optimal treatment has yet to be reached. Read More

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December 2018

Glycodelin as a Serum and Tissue Biomarker for Metastatic and Advanced NSCLC.

Cancers (Basel) 2018 Dec 4;10(12). Epub 2018 Dec 4.

Translational Research Unit, Thoraxklinik at University Hospital Heidelberg, D-69126 Heidelberg, Germany.

A major part of non-small cell lung cancer (NSCLC) patients treated with mono- or multimodal concept develop therapy resistance. Despite the abundance of biomarkers investigated in the past, there is still a need for valid NSCLC biomarkers. Glycodelin, an immunosuppressive endometrial protein, has been shown to be also expressed in NSCLC. Read More

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December 2018

One-step nucleic acid amplification vs ultrastaging in the detection of sentinel lymph node metastasis in endometrial cancer patients.

J Surg Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Gynaecology and Obstetrics, University Hospital Pilsen, Charles University, Prague, Czech Republic.

Background And Objectives: Utilisation of the one-step nucleic acid amplification (OSNA) molecular biology method for the detection of the metastatic involvement of sentinel lymph nodes (SLNs) in endometrial cancer (EC) patients. A comparison with histopathological ultrastaging and a description of the clinical consequences.

Methods: Surgically treated EC patients underwent detection of SLNs. Read More

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December 2018

Aromatase inhibitor therapy for endometrial stromal sarcoma - two-centre experience.

Ginekol Pol 2018 ;89(11):607-610

Department of Oncology and Radiotherapy, Medical University of Gdansk, Poland.

Objectives: Endocrine therapy is the recommended systemic treatment for steroid receptor positive endometrial stromal sarcoma (ESS). There is no current consensus on the optimal hormonal therapy for ESS. The literature offers several reports on advanced/recurrent/metastatic ESS patients treated with progestins, whereas data on the efficacy of aromatase inhibitors are scarce. Read More

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January 2018

The preoperative serum CA125 can predict the lymph node metastasis in endometrioid-type endometrial cancer.

Ginekol Pol 2018 ;89(11):599-606

Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Department of Gynecology, Ankara, Turkey.

Objectives: To evaluate the predictive value of preoperative CA125 in extra-uterine disease and its association with poor prognostic factors in endometrioid-type endometrial cancer (EC).

Material And Methods: A total of 423 patients with pathologically proven endometrioid-type EC were included in the study. The association between preoperative CA125 level and surgical-pathological factors was evaluated. Read More

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January 2018

The effect of orexin B on steroidogenic acute regulatory protein, p450 side chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase gene expression, progesterone and androstenedione secretion by the porcine uterus during early pregnancy and the oestrous cycle.

J Anim Sci 2018 Dec 2. Epub 2018 Dec 2.

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland.

The aim of this study was to investigate the effect of orexin B (OXB) on progesterone (P4) and androstenedione (A4) secretion by porcine endometrial and myometrial tissue explants and on the expression of key steroidogenic proteins and enzymes involved in steroid production. The hormones secretion and the expression of steroidogenic acute regulatory protein (StAR), P450 side-chain cleavage enzyme (CYP11A1) and 3β-hydroxysteroid dehydrogenase (HSD3B1) was analyzed on days 10 to 11, 12 to 13, 15 to 16, 27 to 28 of pregnancy and during the luteal phase of the oestrous cycle (days 10 to 11). Endometrial and myometrial explants were cultured in vitro in the presence of OXB (1, 10 or 100 nM) and OXB (1, 10 or 100 nM) with 1 µM of JNJ (OX2R antagonist). Read More

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December 2018

Molecular characterization of endometrial cancer and therapeutic implications.

Curr Opin Obstet Gynecol 2018 Nov 30. Epub 2018 Nov 30.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women's Health, University of Minnesota School of Medicine.

Purpose Of Review: The present article reviews genomic subtyping of endometrial carcinoma and new molecular markers with therapeutic and prognostic implications.

Recent Findings: Endometrial cancer has historically been classified through histology into endometrioid (type 1) and nonendometrioid (type II, mainly serous) subtypes. Molecular classification through genomic analysis now allows for a major advance in characterization; four distinct subgroups have been identified: polymerase ε (POLE) ultramutated, microsatellite unstable, copy number low/microsatellite stable, and copy number high/'serous-like'. Read More

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November 2018

Investigation of platelet-rich plasma in increasing proliferation and migration of endometrial mesenchymal stem cells and improving pregnancy outcome of patients with thin endometrium.

J Cell Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of Reproductive Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Background: Platelet-rich plasma (PRP) contains abundant growth factors and is gradually used in the field of reproduction. A thin endometrium is recognized as a critical factor in embryo implantation failure. Endometrial mesenchymal stem cells (EnMSCs), which were isolated from human menstrual blood, are highly proliferative and show multiple differentiation capacity. Read More

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December 2018

Office treatment of large endometrial polyps using truclear 5C: Feasibility and acceptability.

J Obstet Gynaecol Res 2018 Dec 2. Epub 2018 Dec 2.

2nd Unit of Obstetrics and Gynecology, Department of Biomedical Science and Human Oncology, University of Bari, Bari, Italy.

Aim: This retrospective multicenter study was carried out to evaluate feasibility, effectiveness and patient acceptability of a small diameter hysteroscopic tissue removal system in the treatment of large endometrial polyps (≥20 mm), usually not removed in an office setting.

Methods: Hundred and forty-six women with a single greater than 10-mm diameter polyp considered for polypectomy between April 2016 and August 2017. Sixty-five of these patients had a polyp size greater than 20 mm. Read More

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December 2018
1 Read

Sectioning and extensively examining the fimbriated end (SEE-FIM) of the fallopian tube in routine practices, is it worth the effort?

J Obstet Gynaecol Res 2018 Dec 2. Epub 2018 Dec 2.

Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Aim: To determine the prevalence of fallopian tube high-grade serous carcinoma (HGSC) and to analyze the benefit of the sectioning and extensively examining the fimbriated end (SEE-FIM) protocol.

Methods: Fallopian tubes from 450 patients with risk-reducing salpingo-oophorectomy, or tumor of the ovary, endometrium, fallopian tube or peritoneum were examined using the SEE-FIM protocol. Microscopic tubal pathology and the number of paraffin blocks used were evaluated. Read More

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December 2018

Long non-coding RNA AFAP1-AS1 promoting epithelial-mesenchymal transition of endometriosis is correlated with transcription factor ZEB1.

Am J Reprod Immunol 2018 Nov 30:e13074. Epub 2018 Nov 30.

First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China.

Problem: The role of the long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) in the etiology of endometriosis is unknown.

Method Of Study: Expression of epithelial-mesenchymal transition (EMT) markers was quantified using qRT-PCR, immunohistochemistry, and western blotting. The proliferation, migration, and invasion of ectopic endometrial epithelial cells and Ishikawa cells were evaluated by MTT, EdU, wound healing, and transwell assays. Read More

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November 2018
1 Read

Ultrasonographic Findings of Uterine Carcinosarcoma.

Gynecol Obstet Invest 2018 Nov 30:1-6. Epub 2018 Nov 30.

Department of Ultrasonic Diagnosis, Obstetrics and Gynecology Hospital, Fudan University, Shanghai,

Aims: The aim of this study was to investigate the clinical features and ultrasonographic findings of uterine carcinosarcoma (UCS).

Methods: Seventy-five patients (mean age, 58.6 years) with pathologically proven UCS who were treated at our hospital from January 2003 to December 2015 were retrospectively recruited. Read More

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November 2018
1 Read

PTEN Hamartoma Tumor Syndrome and Immune Dysregulation.

Transl Oncol 2018 Nov 29;12(2):361-367. Epub 2018 Nov 29.

Department of Human Genetics, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands; Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 28, 6525, GA, Nijmegen, The Netherlands. Electronic address:

Carriers of a pathogenic germline mutations in the PTEN gene, a well-known tumor suppressor gene, are at increased risk of multiple benign and malignant tumors, e.g. breast, thyroid, endometrial and colon cancer. Read More

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November 2018
1 Read

Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.

Exp Mol Pathol 2018 Nov 29. Epub 2018 Nov 29.

Departments of Pathology, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-Ku, Sapporo 060-8556, Japan; CREST, Japan Science and Technology Agency, Tokyo 102-0076, Japan. Electronic address:

Uterine endometrial carcinoma is one of the common cancers in females. Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) are a small subpopulation of cancer cells that are tumorigenic and are resistant to treatments, thus they are focused as treatment targets. However, the heterogeneity of CSCs/CICs is still elusive, and we therefore analyzed CSCs/CICs at the clonal level. Read More

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November 2018

Chemotherapy in older adult gynecologic oncology patients: Can a phenotypic frailty score predict tolerance?

Gynecol Oncol 2018 Nov 28. Epub 2018 Nov 28.

Division of Gynecologic Oncology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Objective: Evaluate the ability of an office-administered phenotypic frailty assessment to predict chemotherapy tolerance in older adult gynecologic oncology patients, and describe practice patterns for chemotherapy administration in this population.

Methods: Prospective, single-institution cohort study of gynecologic oncology patients 65 or older initiating chemotherapy. Phenotypic frailty testing at an office visit encompassed components of two validated frailty assessments: Fried Score (physical testing and patient response) and FRAIL Scale (patient response only). Read More

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November 2018

Synthetic cannabinoids and endometrial stromal cell fate: dissimilar effects of JWH-122, UR-144 and WIN55,212-2.

Toxicology 2018 Nov 28. Epub 2018 Nov 28.

UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n.º 228, Porto, Portugal. Electronic address:

The emergence of synthetic cannabinoids (SCBs) as drugs of abuse in readily available "Spice" smoking blends has exposed users to much more potent cannabinoids than the phytocannabinoids present in Cannabis sativa L.. Increasing reports of adverse reactions are emerging in the clinical literature. Read More

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November 2018

Influence of Prior Psychiatric Disorders on the Treatment Course of Gynaecological Cancer - A Nationwide Cohort Study.

Clin Oncol (R Coll Radiol) 2018 Nov 27. Epub 2018 Nov 27.

Research Unit of Clinical Epidemiology, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark; Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark.

Aims: To examine the influence of pre-existing psychiatric disorder on the choice of treatment in patients with gynaecological cancer.

Materials And Methods: The analyses were based on all patients who underwent surgical treatment for endometrial, ovarian or cervical cancer who were registered in the Danish Gynecological Cancer Database in the years 2007-2014 (3059 patients with ovarian cancer, 5100 patients with endometrial cancer and 1150 with cervical cancer). Logistic regression model and Cox regression model, adjusted for relevant confounders, were used to estimate the effect of pre-existing psychiatric disorder on the course of cancer treatment. Read More

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November 2018

Endometrial but not Ovarian Response is Associated With Clinical Outcomes and can be Improved by Prolonged Pituitary Downregulation in Patients With Thin and Medium Endometrium.

Reprod Sci 2018 Dec 3:1933719118816835. Epub 2018 Dec 3.

1 Reproductive Medicine Centre, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, China.

The aim of this study is to investigate the effect of ovarian and endometrial response on live birth rates (LBRs) in young normal and high responders and prolonged pituitary downregulation on endometrial receptivity and clinical outcomes in patients with different endometrial thickness. Between January 2013 and December 2017, 9511 patients underwent first in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles with age ≤35 years, follicle stimulating hormone < 10 IU/l, and ≥4 retrieved oocytes were conducted. The estradiol (E) levels on the human chorionic gonadotropin (HCG) day were classified into 4 groups: group 1 (<3000 pg/mL); group 2 (3000-5000 pg/mL); group 3 (5000-7000 pg/mL), and group 4 (≥7000 pg/mL). Read More

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December 2018

Fresh transfer of Day 5 slow-growing embryos versus deferred transfer of vitrified, fully expanded Day 6 blastocysts: which is the optimal approach?

Hum Reprod 2018 Dec 4. Epub 2018 Dec 4.

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology. McGill University Health Care Center, 1001 Decarie Blvd, Montreal, Canada.

Study Question: In IVF cycles in which the entire embryo cohort is slow growing, is it optimal to perform fresh transfer in Day 5 or to extend the culture and transfer in subsequent vitrified-warmed cycles?

Summary Answer: The outcomes depend on the degree of embryo development on Day 5.

What Is Known Already: Slow-growing blastocysts have lower implantation potential when transferred in fresh cycles. It has been suggested that embryo-endometrial asynchrony could explain this finding. Read More

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December 2018

Ovarian reserve in adolescent girls born prematurely.

Horm Mol Biol Clin Investig 2018 Dec 5. Epub 2018 Dec 5.

Regional Children's Clinical Hospital, Kemerovo, Russia.

Background The objective was to estimate ovarian reserve in adolescent girls born prematurely. Materials and methods Two hundred adolescent girls aged 15-16 years who were born prematurely and full term were studied with laboratory, ultrasound and statistical methods. Results Statistically significant differences of the main parameters that characterize ovarian reserve in adolescent girls born prematurely compared to those born full term were specified. Read More

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December 2018
1 Read

Muir-Torre Syndrome With a Frame-shift Mutation in the MSH2 Gene: A Rare Case Report and Literature Review.

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Wuhan University Zhongnan Hospital, and Wuhan University Center for Pathology and Molecular Diagnostics (Q.C., Z.X., S.T., S.X.) Department of Pathology, Hubei Cancer Hospital (Manxiang W., S.J., Mingwei W.), Wuhan, Hubei Province, China Department of Pathology, University of Chicago, Chicago, Illinois (S.X.).

Muir-Torre syndrome is a rare subtype of Lynch syndrome characterized by coincidence of skin neoplasm and visceral malignancies. Here, we report a case of this rare disease, whose diagnosis of the syndrome was first suspected by the pathologist. This was a 60-yr-old woman who presented with an axillary skin nodule, which was diagnosed as basal cell carcinoma. Read More

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December 2018
2 Reads

Primary Angiosarcoma of the Cervix: Case Report of a Rare Lesion.

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Royal Gwent Hospital, Newport (V.I.S., I.W.T.) Department of Pathology, University Hospital of Wales, Cardiff (G.L.R.) Department of Musculoskeletal Pathology, Royal Orthopaedic Hospital, Birmingham (V.P.S.) Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.), UK.

Angiosarcomas of the female genital tract are rare and primary angiosarcoma of the cervix is extremely rare with only one prior case report. We report a case of a primary cervical angiosarcoma in a 43-yr-old woman who presented with heavy vaginal bleeding. Cervical biopsy and subsequent radical hysterectomy showed a malignant vascular tumor which was composed of spindled and epithelioid cells and formed abortive vascular channels. Read More

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December 2018

Performance Characteristics of Endometrial Sampling in Diagnosis of Endometrial Carcinoma.

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia (C.T., H.B., P.B.C., C.B.G.) Department of Laboratory Medicine and Pathobiology, University of Toronto (A.P.) Department of Laboratory Medicine Trillium Health Partners (A.P.) Department of Pathology, Health Sciences Center and University of Manitoba, Winnipeg, Manitoba (N.A.), Canada.

Outpatient endometrial biopsy can give false-negative results, with a 0.9% reported posttest probability for endometrial carcinoma (EC) after a negative result. Our objective was to determine if there has been any improvement in the performance characteristics of endometrial biopsy over the last 15 yr. Read More

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December 2018
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[COMPARISON OF ULTRASOUND INVESTIGATION METHODS IN POSTMENOPAUSE].

Georgian Med News 2018 Oct(283):19-26

Institute of Pediatrics, Obstetrics and Gynecology named E.M. Lukyanova of the NAS of Ukraine.

The aim of the study is to improve the diagnostic approach in assessing the state of the endometrium with the help of ultrasonic endometrial diagnostics in accordance with the IETА criteria in combination with three-dimensional Doppler indices, calculating the volume of the endometrium, and the 3D reconstruction in postmenopausal women. 167 postmenopausal women underwent a 2D pelvic ultrasound examination and a combined three-dimensional complex pelvic ultrasound examination that included calculation of the volume of the endometrium, three-dimensional dopplerometric indices (vascularization index, blood flow index and vascularization ratio), and 3D-reconstruction mode. In the second stage, the patients underwent hysteroscopy/endometrial bipyroscopy with morphological evaluation of tissue samples, which retrospectively performed analysis of echographic and dopplerometric criteria in patients with benign changes in the endometrium and their comparison with atrophic endometrium. Read More

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October 2018

Stem cells and endometrial regeneration: from basic research to clinical trial.

Curr Stem Cell Res Ther 2018 Dec 5. Epub 2018 Dec 5.

Center for Reproductive Medicine, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing 210029, Jiangsu. China.

Monthly changes in the endometrial cycle indicate the presence of endometrial stem cells. In recent years, various stem cells that exist in the endometrium have been identified and characterized. Additionally, many studies have shown that bone marrow mesenchymal stem cells (BM-MSCs) provide an alternative source for regenerating the endometrium and repairing endometrial injury. Read More

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December 2018

Impact of endometrial thickness during menstruation and endometrial scratching on the pregnancy in frozen-thawed embryo transfer.

J Obstet Gynaecol Res 2018 Dec 4. Epub 2018 Dec 4.

Department of Reproductive Medical Center, Guangdong Women and Children Hospital, Hospital of Guangzhou Medical University, Guangzhou, China.

Aim: This study aimed to investigate the impact of endometrial thickness (EMT) during menstruation and endometrial scratching on the pregnancy in frozen-thawed embryo transfer (FET).

Methods: About 1298 patients receiving FET were retrospectively analyzed and divided according to EMT on the 4th or 5th day of menstruation. Group A: EMT ≤ 3. Read More

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December 2018

α-Parvin and β-parvin in the rat uterus during decidualisation and uterine receptivity.

Histochem Cell Biol 2018 Dec 5. Epub 2018 Dec 5.

Cell and Reproductive Biology Lab, Discipline of Anatomy and Histology, School of Medical Sciences, University of Sydney, Camperdown, Australia.

During early pregnancy, the uterine luminal epithelial cells (UECs) and endometrial stromal cells (ESCs) undergo morphological changes to enable blastocyst implantation. The present study investigates, for the first time, the cytoskeletal-associated proteins and α-actinin superfamily members, α-parvin and β-parvin, during early pregnancy in the rat uterus. These two PARVA proteins are involved in cell adhesion, morphological changes and regulation of other cytoskeletal proteins, through binding with proteins such as actin and integrin-linked kinase. Read More

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December 2018

Histological Pattern of Endometrial Biopsies in Women with Abnormal Uterine Bleeding in a Hospital in North Central Nigeria.

Int J Reprod Med 2018 1;2018:2765927. Epub 2018 Nov 1.

Department of Morbid Anatomy & Forensic Medicine, Obafemi Awolowo University, Ile-Ife 220282, Nigeria.

The study is a retrospective cross-sectional study carried out in the Department of Pathology of Premier Hospital, Abuja, on specimens received over a one-year period. Four hundred and eighty-six samples of endometrial biopsies and curettings from women presenting with abnormal uterine bleeding sent to the histopathology laboratory were analyzed. The most common biopsies were those of product of conception which accounted for 304 cases (62. Read More

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November 2018

Efficacy of Intrauterine Lidocaine Instillation in Reducing Pain during Endometrial Biopsy by Novak.

Pain Res Treat 2018 1;2018:9368298. Epub 2018 Nov 1.

Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.

Abnormal uterine bleeding in women aged 35 years or over is an important clinical sign of many gynecological conditions. The diagnoses of these conditions require the pathological report of the endometrial tissue. Outpatient-based endometrial biopsy is an excellent option compared to standard fractional uterine curettage or hysteroscopy with endometrial biopsy in providing a definite diagnosis for abnormal uterine bleeding as it is less painful and does not require high potency anesthesia. Read More

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November 2018
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Endometrial cancer: an overview of novelties in treatment and related imaging keypoints for local staging.

Cancer Imaging 2018 Dec 4;18(1):45. Epub 2018 Dec 4.

Department of Radiology, Istituto Europeo di Oncologia, via Ripamonti 435, 20141, Milan, Italy.

Endometrial cancer is the most common gynaecologic malignancy in developed countries and its incidence is increasing. First-level treatment, if no contraindicated, is based on surgery. Pre-operative imaging is needed for evaluation of local extent and detection of distant metastases in order to guide treatment planning. Read More

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December 2018

Impaired Localization of Claudin-11 in Endometriotic Epithelial Cells Compared to Endometrial Cells.

Reprod Sci 2018 Dec 4:1933719118811643. Epub 2018 Dec 4.

1 Department of Gynecology and Obstetrics, University of Giessen, Giessen, Germany.

Claudins are the major components of tight junctions and are often deregulated in human cancer, permitting escape of cancer cells along with the acquisition of invasive properties. Similarly, endometrial cells also show invasive capabilities; however, the role of tight junctions in endometriosis has only rarely been examined. In this study, we analyzed the protein expression and localization of claudin-7 and claudin-11 in human eutopic and ectopic endometrium and endometrial cell lines. Read More

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December 2018

CTCF Expression is Essential for Somatic Cell Viability and Protection Against Cancer.

Int J Mol Sci 2018 Nov 30;19(12). Epub 2018 Nov 30.

Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, 2050 NSW, Australia.

CCCTC-binding factor (CTCF) is a conserved transcription factor that performs diverse roles in transcriptional regulation and chromatin architecture. Cancer genome sequencing reveals diverse acquired mutations in , which we have shown functions as a tumour suppressor gene. While CTCF is essential for embryonic development, little is known of its absolute requirement in somatic cells and the consequences of haploinsufficiency. Read More

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November 2018
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Blended Nanostructured Degradable Mesh with Endometrial Mesenchymal Stem Cells Promotes Tissue Integration and Anti-Inflammatory Response in Vivo for Pelvic Floor Application.

Biomacromolecules 2018 Dec 4. Epub 2018 Dec 4.

The current urogynaecological clinical meshes trigger unfavourable foreign body response which leads to graft failure in the long term. To overcome the present challenge we applied a tissue engineering strategy using endometrial SUSD2+ Mesenchymal stem cells (eMSCs) with high regenerative properties. This study delves deeper into foreign body response to SUSD2+ eMSC based degradable PLACL/Gelatin nanofiber meshes using a mice model targeted at understanding immunomodulation and mesh integration in the long term. Read More

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December 2018
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Loss of PTEN expression as diagnostic marker of endometrial precancer: a systematic review and meta-analysis.

Acta Obstet Gynecol Scand 2018 Dec 4. Epub 2018 Dec 4.

Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.

Introduction: Endometrial hyperplasia may be either a benign proliferation or a premalignant lesion. In order to differentiate these two conditions, two possible histologic classifications can be used: the World Health Organization (WHO) classification and the Endometrial Intraepithelial Neoplasia (EIN) classification. The 2018 European Society of Gynaecological Oncology guidelines recommend the use of immunohistochemistry for tumor suppressor protein phosphatase and tensin homolog (PTEN) to improve the differential diagnosis. Read More

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December 2018
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