33,194 results match your criteria Endometrial Carcinoma


Immunohistochemical expression of HIK1083 and MUC6 in endometrial carcinomas.

Histopathology 2019 Apr 25. Epub 2019 Apr 25.

Sunnybrook Health Sciences Centre, Department of Laboratory Medicine and Molecular Diagnostics, Division of Anatomic Pathology, 2075 Bayview Avenue, Toronto, ON, Canada.

Aims: Gastric type endocervical adenocarcinoma (EA) is characterized by aggressive behaviour and pathogenesis independent of human papillomavirus infection. Because of its morphology and frequent mutation-pattern expression of p53, gastric type EA may be confused with several types of endometrial carcinoma, particularly in biopsy and curettage specimens. HIK1083 and MUC6 are immunohistochemical markers used to support a diagnosis of gastric type EA, however the rates of expression of these markers in endometrial tumours is largely unknown. Read More

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http://dx.doi.org/10.1111/his.13887DOI Listing

Ovarian preservation for premenopausal women with early-stage endometrial cancer: a Chinese retrospective study.

J Int Med Res 2019 Apr 25:300060518822432. Epub 2019 Apr 25.

1 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Objective: This study aimed to retrospectively investigate the safety of ovarian preservation of premenopausal women with stage 1a endometrial carcinoma.

Methods: We performed a population-based study to identify surgically treated stage Ia endometrial cancer of premenopausal women who were diagnosed between August 1989 and December 2015 in our center. Survival outcomes and recurrence rate were examined for premenopausal women who underwent ovarian preservation. Read More

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http://dx.doi.org/10.1177/0300060518822432DOI Listing

Uterine giant cell carcinoma: a case report and review of the literature.

Turk J Obstet Gynecol 2019 Mar 27;16(1):76-79. Epub 2019 Mar 27.

Akdeniz University Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Gynecologic Oncological Surgery, Antalya, Turkey.

Endometrial carcinoma is the most common genital malignancy in women. Endometrioid type is the most common variant of endometrial carcinoma described in literature. Giant cell carcinoma is a rare, and infrequently reported variant of endometrial carcinoma. Read More

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http://dx.doi.org/10.4274/tjod.galenos.2018.31855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463431PMC

[Summary and expectation of the role of GnRHa in the treatment of breast cancer].

Authors:
X L Li Y Yu X Y Zong

Zhonghua Zhong Liu Za Zhi 2019 Apr;41(4):246-250

Department of Breast Surgery, Shanghai Jiao Tong University affiliated Shanghai Sixth People's Hospital, Shanghai 200233, China.

Gonadotropin-releasing-hormone analogues (GnRHa) are widely used in the treatment of premenopausal breast cancer. The anti-tumor effect of GnRHa is similar to that of surgical castration or chemotherapy, through reversibly inhibiting ovarian function and downregulating the estrogen level in premenopausal female. At the same time, GnRHa can protect the ovarian function, avoiding premature ovarian failure. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.04.002DOI Listing

Gastric-type endocervical adenocarcinoma with uterine corpus involvement mimicking primary endometrial carcinoma.

J Obstet Gynaecol Res 2019 Apr 22. Epub 2019 Apr 22.

Department of Obstetrics and Gynecology, Takatsuki General Hospital, Japan.

Differentiation of endocervical adenocarcinomas involving the uterine corpus from primary endometrial (EM) carcinomas involving the cervix is, not only clinically but also pathologically, often difficult. We report a case of gastric-type endocervical adenocarcinoma involving the corpus that could be correctly diagnosed because it was a unique endocervical adenocarcinoma subtype. A 69-year-old woman who presented with abnormal genital bleeding was diagnosed as having a uterine adenocarcinoma on pathological examination of EM biopsy. Read More

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http://dx.doi.org/10.1111/jog.13973DOI Listing

Poor outcome in hypoxic endometrial carcinoma is related to vascular density.

Br J Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Obstetrics and Gynaecology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients.

Methods: Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). Read More

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http://dx.doi.org/10.1038/s41416-019-0461-2DOI Listing

Decreased ADAMTS-1, -9 and -20 levels in women with endometrial polyps: a possible link between extracellular matrix proteases and endometrial pathologies.

J Obstet Gynaecol 2019 Apr 22:1-6. Epub 2019 Apr 22.

b Department of Clinical Biochemistry , Ankara Numune Training and Research Hospital University of Health Sciences , Ankara , Turkey.

A disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs (ADAMTS) protein superfamily includes 19 secreted metalloproteases. Proteolytic substrates of ADAMTS enzymes have been linked to female reproductive function. Herein, we aimed to investigate serum ADAMTS-1, -9 and -20 levels in women with and without endometrial polyps (EPs). Read More

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http://dx.doi.org/10.1080/01443615.2019.1584890DOI Listing

Majority of -Mutant and -Deficient Colorectal Carcinomas Achieve Clinical Benefit From Immune Checkpoint Inhibitor Therapy and Are Microsatellite Instability-High.

JCO Precis Oncol 2019 4;3. Epub 2019 Mar 4.

Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: Microsatellite instability-high (MSI-H) colorectal carcinomas (CRCs) show high rates of response to immune checkpoint inhibitors (IOs). mutations and protein loss have been proposed as causes of resistance to IOs, yet they are enriched in MSI-H CRC. We aimed to characterize -mutant, IO-naive CRC. Read More

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http://dx.doi.org/10.1200/PO.18.00321DOI Listing

[A prospective cohort study about the screening tests of mismatch repair protein and clinical criteria for Lynch syndrome associated endometrial carcinoma].

Zhonghua Yi Xue Za Zhi 2019 Apr;99(15):1178-1183

Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

Currently, the commonly used screening methods for Lynch syndrome in patients with endometrial cancer (EC) are clinical diagnostic criteria and immunohistochemical testing. Our study compared the accuracy of the two methods in this prospective cohort study. Mismatch repair (MMR) protein was detected by immunohistochemical in the pathological tissues of newly diagnosed EC patients in Peking Union Medical College Hospital, during December 2015 and June 2018. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.15.012DOI Listing

Overexpression of FER1L4 promotes the apoptosis and suppresses epithelial-mesenchymal transition and stemness markers via activating PI3K/AKT signaling pathway in osteosarcoma cells.

Pathol Res Pract 2019 Apr 6. Epub 2019 Apr 6.

Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, 100050, PR China.

Novel long non-coding RNA Fer-1-like protein 4 (FER1L4) has been identified as a tumor suppressor in endometrial carcinoma, ovarian cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma. However, the function of FER1L4 in osteosarcoma has not been clear. The aim of the research was to explore the effects of FER1L4 in osteosarcoma. Read More

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http://dx.doi.org/10.1016/j.prp.2019.04.004DOI Listing

Is there any difference between endometrial hyperplasia and endometrial carcinoma in terms of expression of TRPM2 and TRPM7 ion channels?

Turk J Med Sci 2019 Apr 18;49(2):653-660. Epub 2019 Apr 18.

Background/aim: This study compared TRPM2 and TRPM7 ion channel gene expression and immunohistochemical staining in endometrial hyperplasia and endometrium adenocarcinoma.

Materials And Methods: Sections were taken from paraffin blocks of 120 patients who were divided into 6 groups as follows: G1 (n = 20), proliferative endometrium (PE); G2 (n = 20), EH without atypia; G3 (n = 20), EH with atypia; G4 (n = 20), stage 1A, grade 1 EC; G5 (n = 20), stage 1A, grade 2 EC; and G6 (n = 20), stage 1A, grade 3 EC. TRPM2 and TRPM7 genes were analyzed with qRT-PCR in paraffin-embedded tissue samples. Read More

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http://dx.doi.org/10.3906/sag-1810-176DOI Listing
April 2019
1 Read

Reproductive outcomes following treatment for a gynecological cancer diagnosis: a systematic review.

J Cancer Surviv 2019 Apr 17;13(2):269-281. Epub 2019 Apr 17.

Kids Cancer Centre, Sydney Children's Hospital, Sydney, NSW, 2031, Australia.

Purpose: Fertility treatments are available for women diagnosed with a gynecological malignancy, which is important for women who desire a biological family subsequent to treatment. The objective of this study was to report reproductive outcomes following fertility-sparing treatment for a gynaecological cancer.

Methods: Electronic databases were searched to identify studies that reported on reproductive outcomes after treatment for a gynecological malignancy. Read More

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http://link.springer.com/10.1007/s11764-019-00749-x
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http://dx.doi.org/10.1007/s11764-019-00749-xDOI Listing
April 2019
2 Reads

Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer.

J Clin Oncol 2019 Apr 17:JCO1801575. Epub 2019 Apr 17.

17 University of Texas Southwestern Medical Center, Dallas, TX.

Purpose: The primary objective was to determine if vaginal cuff brachytherapy and chemotherapy (VCB/C) increases recurrence-free survival (RFS) compared with pelvic radiation therapy (RT) in high-intermediate and high-risk early-stage endometrial carcinoma.

Patients And Methods: A randomized phase III trial was performed in eligible patients with endometrial cancer. Eligible patients had International Federation of Gynecology and Obstetrics (2009) stage I endometrioid histology with Gynecologic Oncology Group protocol 33-based high-intermediate-risk criteria, stage II disease, or stage I to II serous or clear cell tumors. Read More

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http://dx.doi.org/10.1200/JCO.18.01575DOI Listing
April 2019
1 Read

Conservative management of endometrial intraepithelial neoplasia in a patient with cirrhosis undergoing orthotopic liver transplant.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, IL.

Objective: The aim of the study was to review the management of endometrial hyperplasia in a woman undergoing liver transplantation for alcoholic cirrhosis.

Methods: This is a case presentation on a postmenopausal woman with a tissue diagnosis of endometrial intraepithelial neoplasia managed with a levonorgestrel intrauterine device, before and after liver transplantation. Full written informed consent was obtained from the patient to present her case. Read More

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http://dx.doi.org/10.1097/GME.0000000000001342DOI Listing
April 2019
1 Read

Cyclin A is a reliable proliferation marker in endometrial cancer cell lines.

Oncol Lett 2019 May 8;17(5):4455-4462. Epub 2019 Mar 8.

Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036-8564, Japan.

Cyclin A, a cell cycle regulatory protein, promotes cell proliferation and has been observed to be highly expressed in cancer and to promote tumor growth; however, its value as a marker for endometrial carcinoma has not yet been established. Accordingly, the aim of the present study was to clarify whether cyclin A can be used as a cell proliferation marker using the endometrial carcinoma cell lines Ishikawa and HEC-50B, derived from patients with low-grade and high-grade cancer, respectively. The expression of cyclin A was determined by flow cytometry using double staining with FITC and 7-AAD, and immunocytochemical staining. Read More

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http://www.spandidos-publications.com/10.3892/ol.2019.10135
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http://dx.doi.org/10.3892/ol.2019.10135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447861PMC
May 2019
1 Read

LncRNA CCAT1 negatively regulates miR-181a-5p to promote endometrial carcinoma cell proliferation and migration.

Exp Ther Med 2019 May 20;17(5):4259-4266. Epub 2019 Mar 20.

Department of Gynecology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China.

Long non-coding RNAs (lncRNAs) are identified as vital modulators in a number of biological processes, including tumorigenesis. However, the role of lncRNAs in endometrial carcinoma (EC) remains unknown. In the current study, the expression patterns, biological roles and functional mechanism of the lncRNA colon cancer associated transcript 1 (CCAT1) was examined in EC. Read More

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http://dx.doi.org/10.3892/etm.2019.7422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447908PMC
May 2019
0.941 Impact Factor

Effects of RNAi-induced Skp2 inhibition on cell cycle, apoptosis and proliferation of endometrial carcinoma cells.

Exp Ther Med 2019 May 13;17(5):3441-3450. Epub 2019 Mar 13.

Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.

The aim of the current study was to investigate the underlying mechanism of S-phase kinase associated protein 2 (Skp2) gene inhibition by lentivirus-mediated RNA interference (RNAi) on the cell cycle, apoptosis and proliferation of endometrial carcinoma HEC-1-A cells. A lentivirus shRNA vector targeting Skp2 was constructed and transfected into HEC-1-A cells. HEC-1-A cells transfected with a scramble sequence were used as negative controls. Read More

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http://dx.doi.org/10.3892/etm.2019.7392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447788PMC
May 2019
2 Reads

Primary yolk sac tumor originating from the endometrium: A case report and literature review.

Medicine (Baltimore) 2019 Apr;98(15):e15144

The Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan.

Rationale: Yolk sac tumors (YSTs) are malignant germ cell tumors that secrete alpha-fetoprotein (AFP). These tumors commonly develop in infants, young children, and young women and often originate in the gonads. Primary endometrial YST is a very rare malignancy, and a primary endometrial YST in the absence of abnormal AFP levels is even rarer. Read More

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http://dx.doi.org/10.1097/MD.0000000000015144DOI Listing

A Rare Case of Primary Endometrial Hepatoid Adenocarcinoma on 18F-FDG PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Departments of Nuclear Medicine and.

Primary endometrial hepatoid adenocarcinoma is a rare tumor. We present a case of a 64-year-old woman with vaginal bleeding for 2 months and a markedly elevated serum α-fetoprotein of 3931 ng/mL. Hysteroscopic segmental curettage revealed endometrial adenocarcinoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002538DOI Listing
April 2019
3 Reads

Large cell neuroendocrine carcinoma of the endometrium: a report and review of the literature.

Gynecol Oncol Rep 2019 May 13;28:96-100. Epub 2019 Mar 13.

The University of Tennessee, Knoxville, Department of Obstetrics and Gynecology and Graduate School of Medicine, United States of America.

Large-cell neuroendocrine tumor of the endometrium is a rare tumor type which is difficult to diagnose. Our routine tissue sampling is often non-productive and these tumors can be mistaken for other poorly differentiated carcinomas. Sites of metastatic disease sometimes confuse the identification of the primary organ, and histological diagnosis requires a choice of neuroendocrine biomarkers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23525789193002
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http://dx.doi.org/10.1016/j.gore.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441730PMC
May 2019
2 Reads

Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Local and Contralateral Recurrence in Breast Intraepithelial Neoplasia.

J Clin Oncol 2019 Apr 11:JCO1801779. Epub 2019 Apr 11.

3 European Institute of Oncology IRCCS, Milan, Italy.

Purpose: Tamoxifen administered for 5 years at 20 mg/d is effective in breast cancer treatment and prevention, but toxicity has limited its broad use. Biomarker trials showed that 5 mg/d is not inferior to 20 mg/d in decreasing breast cancer proliferation. We hypothesized that a lower dose given for a shorter period could be as effective in preventing recurrence from breast intraepithelial neoplasia but have a lower toxicity than the standard dose. Read More

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http://dx.doi.org/10.1200/JCO.18.01779DOI Listing
April 2019
2 Reads

Uterine Papillary Serous Carcinoma Arising in a Polyp: A Multicenter Retrospective Analysis on 75 Patients.

Am J Clin Oncol 2019 May;42(5):472-480

Unit of Obstetrics and Gynecology, Azienda USL-IRCCS of Reggio Emilia.

Objectives: The objectives of this study were to evaluate whether the international recommendations on the management of uterine papillary serous carcinoma arising in a polyp are uniformly followed in Italian Oncologic Centers and whether the strategy adopted is effective.

Materials And Methods: Patients with uterine papillary serous carcinoma arising in a polyp and who had undergone a hysterectomy were identified in the 2003-2013 database of 7 Italian Gynecologic Oncology Centers. Clinical and pathologic characteristics and outcomes were compared between staging procedure types. Read More

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http://dx.doi.org/10.1097/COC.0000000000000541DOI Listing
May 2019
1 Read

MiR-181c affects estrogen-dependent endometrial carcinoma cell growth by targeting PTEN.

Endocr J 2019 Apr 11. Epub 2019 Apr 11.

Department of Center for Reproductive Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, China.

MicroRNAs (miRNAs), which is a type of non-coding and single-stranded small molecule RNA, bind either completely or incompletely to 3'-UTR of the target gene mRNA to inhibit mRNA translation or degradation. In our study, we aimed to explore the roles and mechanisms of miR-181c in the apoptosis of RL95-2 human endometrial carcinoma cells. Cell activity and apoptosis were detected by cell counting Kit-8 (CCK-8) assay and flow cytometry (FCM), respectively. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0538DOI Listing
April 2019
1 Read

[A suspected carcinoma finding in the uterus].

Pathologe 2019 Apr 9. Epub 2019 Apr 9.

Institut für Pathologie am Clemenshospital, Düesbergweg 128, 48153, Münster, Deutschland.

Epithelioid tumor cells of a uterine perivascular epithelioid cell tumor (PEComa) may mimic carcinoma cells in an endometrial sampling (pitfall). Immunohistochemistry (HMB45 positive, keratin negative) helps in the differential diagnosis. Read More

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http://dx.doi.org/10.1007/s00292-019-0587-2DOI Listing
April 2019
1 Read

Clinical presentation of brain metastases from endometrial carcinoma: A case series.

Gynecol Oncol Rep 2019 May 20;28:79-83. Epub 2019 Mar 20.

University of Colorado Denver, Department of Obstetrics and Gynecology, Aurora, CO, United States.

Brain metastases from endometrial carcinoma are rare, however they do occur, and they are associated with an especially poor prognosis. There is evidence demonstrating improved outcomes with early diagnosis and subsequent multimodal treatment. This study therefore aims to review cases of brain metastases from endometrial carcinoma with specific focus on clinical presentation and disease history. Read More

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http://dx.doi.org/10.1016/j.gore.2019.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434091PMC
May 2019
2 Reads

Zone Formation of Lymphocyte Infiltration at the Invasive Front Results in the Prolonged Survival of Individuals With Endometrial Serous Carcinoma and Endometrioid Carcinoma With Serous Component.

Anticancer Res 2019 Apr;39(4):2085-2089

Department of Obstetrics and Gynecology, National Defense Medical College Hospital, Tokorozawa, Japan.

Background/aim: This study aimed to evaluate the clinical significance of lymphocyte infiltration (LI) for patients with endometrial serous carcinoma and those with endometrioid carcinoma including serous component.

Patients And Methods: Patients who underwent surgery at our hospital between 1990 and 2013 were identified. LI was classified into strong LI, defined as a continuous thick zone of LI, and weak LI, defined as the lack of zone or scattered small foci of LI at the invasive front. Read More

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http://dx.doi.org/10.21873/anticanres.13320DOI Listing
April 2019
2 Reads

Preventive Effects by Black Raspberries of Endometrial Carcinoma Initiation and Promotion Induced by a High-Fat Diet.

Mol Nutr Food Res 2019 Apr 5:e1900013. Epub 2019 Apr 5.

Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.

Scope: The chemopreventive effects of black raspberries (BRBs) have not been studied in endometrial tumorigenesis. Here, they are examined in a mouse model of endometrial cancer.

Methods And Results: Wild-type and Pten heterozygous (+/-) female mice are weaned at 3 weeks and fed with four AIN-93G diets: 93G; 93G+5% BRBs powder; high-fat (HF); and HF+5% BRBs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.2019000
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http://dx.doi.org/10.1002/mnfr.201900013DOI Listing
April 2019
2 Reads

Can preoperative magnetic resonance imaging replace intraoperative frozen sectioning in the evaluation of myometrial invasion for early-stage endometrial carcinoma?

Ginekol Pol 2019 ;90(3):128-133

Department of Gynecologic Oncology,University of Health Sciences Tepecik Education and Research Hospital, İzmir, Turkey.

Objectives: To examine the performance of preoperative magnetic resonance imaging (MRI) and intraoperative frozen sectioning in the assessment of myometrial invasion during the early stages of endometrial cancer.

Material And Methods: This retrospective study employed data from patients with endometrial cancer who were operated on between January 2013 and November 2018. Patients who underwent preoperative MRI and were of FIGO 2009 stage I were included in the study. Read More

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http://dx.doi.org/10.5603/GP.2019.0023DOI Listing
January 2019
5 Reads

Role of Positron Emission Tomography/Computed Tomography in Preoperative Assessment of Carcinoma Endometrium-a Retrospective Analysis.

Indian J Surg Oncol 2019 Mar 20;10(1):225-231. Epub 2018 Nov 20.

4Department of Onco - Pathology, HCG hospital, Bengaluru, India.

PET/CT has made significant inroads into routine oncological practice in recent times. In our study, we aim to determine its value in preoperative assessment of endometrial carcinoma. A retrospective study between January 2011 and March 2016 was conducted; we included all cases of carcinoma endometrium with a preoperative PET/CT scan. Read More

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http://link.springer.com/10.1007/s13193-018-0826-7
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http://dx.doi.org/10.1007/s13193-018-0826-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414595PMC
March 2019
6 Reads

A Prospective Observational Study Evaluating the Accuracy of MRI in Predicting the Extent of Disease in Endometrial Cancer.

Indian J Surg Oncol 2019 Mar 17;10(1):220-224. Epub 2018 Dec 17.

4Department of Pathology, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, Kerala India.

This prospective study looks into the accuracy of magnetic resonance imaging (MRI) in predicting the depth of MI, cervical invasion, lymph node metastasis, and extrauterine spread (EUS) of disease in endometrial cancer. Between June 2014 and December 2015, 58 patients with biopsy-proven endometrial cancer who underwent MRI prior to surgery were included in the study. MRI findings like myometrial invasion, extrauterine spread, lymph nodal metastasis, and cervical invasion were compared against the histopathology report. Read More

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http://dx.doi.org/10.1007/s13193-018-0832-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414579PMC
March 2019
2 Reads

Expression of p53 and PTEN in human primary endometrial carcinomas: Clinicopathological and immunohistochemical analysis and study of their concomitant expression.

Oncol Lett 2019 May 1;17(5):4575-4589. Epub 2019 Mar 1.

First Pathology Department, Medical School, National Kapodistrian University, Athens 11527, Greece.

Endometrial carcinoma is a common malignancy of the female genital tract. Alterations in the expression levels of various oncogenes and tumor suppressor genes serve important roles in the carcinogenesis and biological behavior of endometrial carcinoma. The aim of the present study was to evaluate the combination and individual expression of p53 and phosphatase and tensin homolog (PTEN) protein in human endometrial carcinoma. Read More

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http://dx.doi.org/10.3892/ol.2019.10093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444490PMC
May 2019
3 Reads

Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions.

BMC Cancer 2019 Apr 3;19(1):308. Epub 2019 Apr 3.

Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

Background: Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involvement in ovarian tumorigenesis. Herein, we focused on the functional roles of Nodal in ovarian endometriosis-carcinoma lesions. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5539-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448249PMC
April 2019
7 Reads

Analysis of polymorphisms in genes associated with the FA/BRCA pathway in three patients with multiple primary malignant neoplasms.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1101-1112

a The National Engineering Research Center for Miniaturized Detection Systems, The College of Life Sciences , Northwest University , Xi'an , PR China.

Cases of more than three primary cancers are very rare. This study analyzed the genetic susceptibility of gene polymorphisms in three patients with multiple primary malignant neoplasms and examined the possible pathogenesis. The clinical data and whole genome sequence of three patients (1 with 5 primary cancers, 1 with 4 primary cancers, and 1 with 3 primary cancers) were aligned with a series of databases. Read More

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http://dx.doi.org/10.1080/21691401.2019.1575846DOI Listing
December 2019
1 Read

Carcinosarcoma of the uterine cervix: a rare pathological finding originating from mesonephric remnants.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Gynecology Oncology, Instituto Português de Oncologia do Porto Francisco Gentil, Porto, Portugal.

Carcinosarcoma of the uterine cervix is a very rare tumour that has been described in less than 70 cases in the literature. It is less common compared with carcinosarcoma of the uterine corpus and it can have two origins: the Müllerian ducts and the mesonephric duct remnants. The association of mesonephric carcinoma with a sarcomatous component was reported in only 11 cases, including the following. Read More

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http://dx.doi.org/10.1136/bcr-2018-227050DOI Listing
March 2019
3 Reads

SOX11 hypermethylation as a tumor biomarker in endometrial cancer.

Biochimie 2019 Mar 29;162:8-14. Epub 2019 Mar 29.

Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. Electronic address:

We previously reported that SOX4 is overexpressed in endometrial cancer and that it partially contributes to hypermethylation of miR-129-2 and miR-203. The current study seeks to identify methylation and expression levels of the SOX gene family in endometrial carcinomas. Methylation levels of the 16 SOX gene family members were measured by combining bisulfite restriction analysis (COBRA), MassARRAY, and pyrosequencing assays of cell lines and endometrial cancer samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03009084193008
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http://dx.doi.org/10.1016/j.biochi.2019.03.019DOI Listing
March 2019
5 Reads

Inhibition of PSMD4 blocks the tumorigenesis of hepatocellular carcinoma.

Gene 2019 Mar 28;702:66-74. Epub 2019 Mar 28.

Department of Gastroenterology, Qilu Hospital of Shandong University, China. Electronic address:

Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver with high mortality and frequent recurrence. Although various therapies provide potential cure for HCC patients, unfortunately the five-year survival rate of advanced HCC remains dismal. It is critical to explore the pathogenesis of HCC and identify novel biomarkers for early HCC diagnosis. Read More

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http://dx.doi.org/10.1016/j.gene.2019.03.063DOI Listing
March 2019
3 Reads

PGK1 facilities cisplatin chemoresistance by triggering HSP90/ERK pathway mediated DNA repair and methylation in endometrial endometrioid adenocarcinoma.

Mol Med 2019 03 29;25(1):11. Epub 2019 Mar 29.

Department of Gynecology, Jiangsu Province Hospital, Room 1711, No.220, Jiangdongbei Road, Gulou District, Nanjing, 210000, Jiangsu Province, People's Republic of China.

Background: Endometrial carcinoma represents one of the most common cancer types of the female reproductive tract. If diagnosed at an early stage, the 5-year survival rate is promising. However, recurrence and chemoresistance remain problematic for at least 15% of the patients. Read More

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http://dx.doi.org/10.1186/s10020-019-0079-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441178PMC
March 2019
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Letter to the Editor on 'dietary patterns and endometrial cancer: a meta-analysis'.

Eur J Cancer Prev 2019 05;28(3):243

Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

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http://dx.doi.org/10.1097/CEJ.0000000000000445DOI Listing
May 2019
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3.031 Impact Factor

The antitumor effect of lobaplatin against Ishikawa endometrial cancer cells in vitro and in vivo.

Biomed Pharmacother 2019 Mar 26;114:108762. Epub 2019 Mar 26.

Department of Oncology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao, Nanjing 210009, China. Electronic address:

The new effective chemotherapeutic drugs are required urgently for advanced and recurrent endometrial carcinoma (EC), which is one of the most common gynaecological tumors among women worldwide. Preclinical studies have shown that lobaplatin, one of the third-generation platinum compounds, has possessed powerful anti-cancer efficacy on a series of tumors. The purpose of this study is to investigate its effect and molecular mechanism on the growth of endometrial cancer cell line Ishikawa in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108762DOI Listing
March 2019
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Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer: an interim analysis of a multicentre, open-label, single-arm, phase 2 trial.

Lancet Oncol 2019 Mar 25. Epub 2019 Mar 25.

Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.

Background: Lenvatinib is a multikinase inhibitor of VEGFR1, VEGFR2, and VEGFR3, and other receptor tyrosine kinases. Pembrolizumab, an antibody targeting PD-1, has moderate efficacy in biomarker-unselected endometrial cancer. We aimed to assess the combination of lenvatinib plus pembrolizumab in patients with advanced endometrial carcinoma, after establishing the maximum tolerated dose in a phase 1b study. Read More

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http://dx.doi.org/10.1016/S1470-2045(19)30020-8DOI Listing
March 2019
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IL-6 promotes endometrial cancer cells invasion and migration through signal transducers and activators of transcription 3 signaling pathway.

Pathol Res Pract 2019 Mar 19. Epub 2019 Mar 19.

Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address:

Interleukin (IL)-6 is the most well-known traditional activator of activating signal transducers and activators of transcription 3 (Stat3). They have been proved to promote cancer progression in several human cancers. However, their exact roles in endometrial cancer have not been elucidated clearly. Read More

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http://dx.doi.org/10.1016/j.prp.2019.03.020DOI Listing
March 2019
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Molecular classification defines outcomes and opportunities in young women with endometrial carcinoma.

Gynecol Oncol 2019 Mar 25. Epub 2019 Mar 25.

Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

Objective: Approximately 15% of endometrial carcinomas (ECs) arise in young women who may wish to avoid surgical menopause and/or preserve fertility. Our aim was to evaluate the prognostic significance of Proactive Molecular risk classifier for Endometrial Carcinoma (ProMisE) in young (<50 yo) women with EC.

Methods: ProMisE was applied to a retrospective cohort of women with ECs <50 yo at diagnosis, and associations between the four ProMisE molecular subtypes (MMR deficient (MMRd), POLE mutated (POLE), p53 wild type (p53wt), and p53 abnormal (p53abn)) and clinicopathological parameters, including outcomes, were assessed. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.03.098DOI Listing
March 2019
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Treatment of uterine high-grade endometrial stromal sarcoma with apatinib combined with chemotherapy: A case report.

Medicine (Baltimore) 2019 Mar;98(13):e15050

Department of Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China.

Rationale: The standard treatment for uterine high-grade endometrial stromal sarcoma (HGESS) is chemotherapy after surgery. However, the traditional combination chemotherapy has certain limitation, for example, the cancer cells will quickly become resistant to the chemotherapy drugs. Apatinib is a small-molecule antiangiogenic agent which has shown promising therapeutic effect against diverse tumor, but it still remains unknown whether apatinib has an antitumor effect in patients with endometrial stromal sarcoma (ESS). Read More

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http://dx.doi.org/10.1097/MD.0000000000015050DOI Listing
March 2019
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Decreased expression of cell polarity protein Scribble correlated with altered subcellular localization of the Crumbs homologue 3 protein in human adenomyotic endometrial cells.

J Obstet Gynaecol Res 2019 Mar 25. Epub 2019 Mar 25.

Department of Obstetrics and Gynecology of Shanghai Medical School, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People's Republic of China.

Aim: Previous studies have revealed that loss of cell apical-basal polarity contributed to the early stages of tumorigenesis. Adenomyosis involves a down-growth and aberrant implantation of the endometrial basalis into the myometrium. This study discovered aberrant expression of polarity protein Scribble (Scrib) and Crumbs homologue 3 protein (CRB3) in epithelial cells of diffuse adenomyosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jog.13952
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http://dx.doi.org/10.1111/jog.13952DOI Listing
March 2019
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Clinical value screening, prognostic significance and key pathway identification of miR-204-5p in endometrial carcinoma: A study based on the Cancer Genome Atlas (TCGA), and bioinformatics analysis.

Pathol Res Pract 2019 May 7;215(5):1003-1011. Epub 2019 Mar 7.

Center for Reproductive Medicine, Third Affiliated Hospital of Guangzhou Medical University, People's Republic of China; Key Laboratory for Reproductive Medicine of Guangdong, People's Republic of China; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, People's Republic of China; Key Laboratory for Major Obstetric Diseases of Guangdong Province, Guangzhou, People's Republic of China. Electronic address:

Background: Endometrial carcinoma is one of the common carcinomas in the female reproductive system. It is reported that miR-204-5p is down-regulated in endometrial carcinoma. However, the mechanism and key pathways of miR-204-5p in endometrial carcinoma have not been clarified. Read More

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http://dx.doi.org/10.1016/j.prp.2019.02.007DOI Listing
May 2019
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Genome-wide profiling of miRNA expression patterns in tubal endometriosis.

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

J Zhang, Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200030, China.

MicroRNA (miRNA) expression profiles in tubal endometriosis (EM) are still poorly understood. In this study, we analyzed the differential expression of miRNAs and the related gene networks and signaling pathways in tubal EM. Four tubal epithelium samples from tubal EM patients and five normal tubal epithelium samples from uterine leiomyoma patients were collected for miRNA microarray. Read More

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http://dx.doi.org/10.1530/REP-18-0631DOI Listing
March 2019
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The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas.

PLoS One 2019 25;14(3):e0214416. Epub 2019 Mar 25.

INSERM U1016, Cochin Institute, CARPEM, Paris, France.

Background: NRF2 is a major transcription factor regulating the expression of antioxidative/detoxifying enzymes, involved in oncogenic processes and drug resistance. We aimed to identify molecular alterations associated with NRF2 activation in endometrial carcinoma (EC).

Methods: Ninety patients treated (2012-2017) for localized/locally advanced EC were included in this study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214416PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433262PMC
March 2019
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Identification of a therapeutic target using molecular sequencing for treatment of recurrent uterine serous adenocarcinoma.

Gynecol Oncol Rep 2019 May 21;28:54-57. Epub 2019 Feb 21.

Department of Obstetrics and Gynecology, Weill Cornell Medicine, United States of America.

Uterine serous adenocarcinoma is a rare but highly malignant form of endometrial cancer, comprising over 50% of recurrences and deaths from endometrial cancer. We report a case of a 68-year old woman with recurrent uterine serous adenocarcinoma who underwent molecular testing and genetic sequencing of her tumor. She was found to have focal amplification of ERBB2 confirmed by amplification and overexpression of HER2/ fluorescence hybridization and immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.gore.2019.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411491PMC
May 2019
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Diagnostic yield of magnetic resonance imaging and intraoperative frozen section in the determination of deep myometrial invasion in endometrial cancer.

Radiologia 2019 Mar 21. Epub 2019 Mar 21.

Servicio de Anatomía Patológica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Background And Objectives: The standard treatment for endometrial cancer is simple hysterectomy with bilateral salpingo-oophorectomy. Patients with high risk also benefit from lumbo-aortic lymphadenectomy. High risk patients include those with grades and histologic subtypes associated with poor prognosis and depth of myometrial invasion greater than 50% (M2). Read More

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http://dx.doi.org/10.1016/j.rx.2019.01.007DOI Listing
March 2019
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Serum SCCA levels in patients suffering cancers or other diseases.

Prog Mol Biol Transl Sci 2019 9;162:165-175. Epub 2019 Mar 9.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Increased serum squamous cell carcinoma antigen (SCCA) levels are clinically used diagnostic or prognostic biomarker for squamous cell carcinomas. According to recently published studies, increased serum SCCA levels are also observed in adenocarcinomas, hepatocarcinomas, kidney, and other inflammatory diseases, indicating squamous cell carcinoma is not the production source of serum SCCA in these diseases. However, serum SCCA levels in patients suffering different types of diseases have not been systematically measured and compared. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18771173183015
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http://dx.doi.org/10.1016/bs.pmbts.2018.12.004DOI Listing
March 2019
7 Reads