8,416 results match your criteria Endolymphatic Hydrops


The role of serum osmolality in Meniere's disease with acute sensorineural hearing loss.

Int J Audiol 2022 Jun 23:1-7. Epub 2022 Jun 23.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.

Objective: This study investigated the role of serum osmolality in Meniere's disease (MD) patients with acute sensorineural hearing loss (SNHL).

Design: Retrospective study.

Study Samples: Twenty definite MD patients with acute unilateral SNHL were treated with an osmotic diuretic (Isosorbide, 100 mL daily) and assigned to Group A. Read More

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12-month effect of middle ear pressure therapy with the EFET01 device for intractable definite Meniere's disease and delayed endolymphatic hydrops after certification by the public health insurance system in Japan.

Acta Otolaryngol 2022 Jun 20:1-8. Epub 2022 Jun 20.

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.

Background: Middle ear pressure therapy (MEPT) is effective for intractable vertigo in patients with definite Meniere's disease (MD) and treatment-refractory delayed endolymphatic hydrops (DEH). Four-month MEPT with the EFET01, an MEPT device developed in Japan and covered by national health insurance since September 2018, has shown efficacy. However, efficacy and safety after 12 months of treatment, which is appropriate for determining the therapeutic effect of MEPT devices, is unclear. Read More

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Space-Occupying Lesions of the Inner Ear Are Easily Misdiagnosed as Endolymphatic Hydrops in a Perilymph-Enhanced Sequence Without the Assistance of a Heavily T2-Weighted Sequence.

J Comput Assist Tomogr 2022 Jun 4. Epub 2022 Jun 4.

Department of Radiology, Eye & ENT Hospital of Fudan University, Shanghai, China.

Objective: The aim of the study was to explore the value of T2-sampling perfection with application-optimized contrasts by using different flip angle evolutions (T2-SPACE) in identifying space-occupying lesions of the inner ear.

Methods: We collected the T2-SPACE and 3-dimensional inversion-recovery sequence with real reconstruction (3D-real IR) images of 220 patients with inner ear symptoms, including 15 patients with inner ear space-occupying lesions. With T2-SPACE images hidden, a senior and junior radiologist made a diagnosis for all patients using only the 3D-real IR images. Read More

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Defective α-tectorin may involve tectorial membrane in familial Meniere disease.

Clin Transl Med 2022 Jun;12(6):e829

Otology & Neurotology Group CTS 495, Department of Genomic Medicine, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain.

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IE-Vnet: Deep Learning-Based Segmentation of the Inner Ear's Total Fluid Space.

Front Neurol 2022 11;13:663200. Epub 2022 May 11.

German Center for Vertigo and Balance Disorders, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.

Background: MR-based high-resolution volumetric quantification methods of the endolymphatic hydrops (ELH) are highly dependent on a reliable segmentation of the inner ear's total fluid space (TFS). This study aimed to develop a novel open-source inner ear TFS segmentation approach using a dedicated deep learning (DL) model.

Methods: The model was based on a V-Net architecture (IE-Vnet) and a multivariate (MR scans: T1, T2, FLAIR, SPACE) training dataset (D1, 179 consecutive patients with peripheral vestibulocochlear syndromes). Read More

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Endolymphatic hydrops presumption tests for patients with vestibular migraine.

Acta Otolaryngol 2022 May 1;142(5):406-409. Epub 2022 Jun 1.

Department of Otolaryngology, St Marianna University School of Medicine, Yokohama, Japan.

Background: The aetiology of vestibular migraine (VM) has not yet been defined; endolymphatic hydrops (EH) has been suggested as a candidate.

Objectives: This study aimed to clarify the relationship between VM and EH using neuro-otological tests, including the EH presumption test.

Materials And Methods: Fourteen patients with VM underwent caloric testing, video head impulse test (vHIT), cervical and ocular vestibular evoked myogenic potential (cVEMP and oVEMP), and EH presumption tests such as the Futaki's test and furosemide loading VEMP. Read More

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[New discovery and short-term effect analysis of tensor tympani muscle tenotomy for Meniere's disease under otoscope].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 May;57(5):602-606

Department of Otorhinolaryngology, Liaocheng People's Hospital, Liaocheng 252000, China.

To explore the feasibility and short-term effect of tensor tympani muscle Tenotomy in the treatment of Meniere's disease under otoscope. The possible pathogenesis was discussed and our views were put forward. The clinical data of 9 cases of Meniere's disease treated by otoscopic Tenotomy were analyzed retrospectively, including 2 males, 7 females, 5 right ones, 2 left ones and 2 bilateral ones. Read More

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Is Inadequate Water Intake a Risk Factor for Vestibular Disorders?

J Int Adv Otol 2022 May;18(3):264-268

Department of Audiology, Hacettepe University Faculty of Health Sciences, Ankara, Turkey.

Background: Water is a vital nutrient for the human body system and failing to consume enough water could cause health problems. The purpose of this study is to investigate the relationship between water intake and vestibular system disorders.

Methods: Data from 93 patients (aged between 20 and 76 years) with vestibular disorders were analyzed in the study. Read More

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Population-based study for the comorbidities and associated factors in Ménière's disease.

Authors:
Min Hee Kim

Sci Rep 2022 May 18;12(1):8266. Epub 2022 May 18.

Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, Kyung Hee University Hospital at Gangdong, Dongnam-ro 892, Seoul, 05278, Republic of Korea.

To date, no study has reported the objective metabolic laboratory findings worldwide or the comorbidities for Ménière's disease (MD) using a population-based design in Asian populations. The aim of this study was to investigate the comorbidities and associated factors for MD using the Korean National Health Insurance Service database. This retrospective population-based study was conducted using a data from the National Sample Cohort database from 2009 to 2015. Read More

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Low Frequency Air-Bone Gap in Meniere's Disease: Relationship With Magnetic Resonance Imaging Features of Endolymphatic Hydrops.

Ear Hear 2022 May 18. Epub 2022 May 18.

School of Biomedical Engineering & Imaging Sciences Clinical Academic Group, King's College London, London, United Kingdom.

Objectives: The appearance of low-frequency air-bone gaps (LFABGs) in Meniere's disease (MD) is a recognized but relatively unexplored phenomenon. Two theories have been proposed to explain their etiology: increased perilymphatic pressure resulting in either reduced stapedial mobility or dampened transmission of acoustic energy, and direct contact between the dilated saccule and the stapes footplate. The aim of this study was to evaluate these two hypotheses by comparing delayed postgadolinium magnetic resonance imaging (MRI) features of two groups of patients with unilateral definite MD, those with and without LFABGs. Read More

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Endolymphatic hydrops in the unaffected ear of patients with unilateral Ménière's disease.

Eur Arch Otorhinolaryngol 2022 May 16. Epub 2022 May 16.

Department of Otorhinolaryngology, Clínica Universidad de Navarra, Pamplona, Spain.

Purpose: Current studies show that frequency tuning modification is a good marker for the detection of endolymphatic hydrops (EH) employing magnetic resonance imaging (MRI) in patients with Ménière's disease (MD). The purpose of the present study is to analyze the auditory and vestibular function with audiometric and vestibular-evoked myogenic potentials (VEMP) responses, respectively, in both the affected and unaffected ears of patients with unilateral MD using MRI as diagnostic support for the degree of EH.

Methods: We retrospectively reviewed the medical records of 76 consecutive patients with unilateral definite MD (age 55 (28-75); 39 women, 37 men). Read More

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Consensus on MR Imaging of Endolymphatic Hydrops in Patients With Suspected Hydropic Ear Disease (Meniere).

Front Surg 2022 28;9:874971. Epub 2022 Apr 28.

Ear Nose and Throat Patient Area, Trauma and Reparative Medicine Theme, Karolinska University Hospital, Stockholm, Sweden.

Endolymphatic hydrops (EH) is considered the histological hallmark of Meniere's disease. Visualization of EH has been achieved by special sequences of inner ear magnetic resonance imaging (MRI) with a gadolinium-based contrast agent intravenous or intratympanic administration. Although it has been applied for more than 10 years since 2007, a unified view on this technique has not yet been achieved. Read More

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Editorial: Hydropic Ear Disease: Imaging and Functional Evaluation.

Authors:
Shinji Naganawa

Front Surg 2022 27;9:913741. Epub 2022 Apr 27.

Department of Radiology, Graduate School of Medicine, Nagoya University, Nagoya, Japan.

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Pitfalls of Using T2-contrast Enhancement Techniques in 3D-FLAIR to Detect Endolymphatic Hydrops.

Magn Reson Med Sci 2022 May 10. Epub 2022 May 10.

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine.

Purpose: To determine whether T2-contrast enhancement techniques can be used to diagnose endolymphatic hydrops, we compared fluid signal artifacts with and without T2-contrast enhancement techniques in 3D fluid-attenuated inversion recovery (3D-FLAIR).

Methods: We prepared a custom-made phantom consisting of eight tubes half-filled with saline. Images were obtained using four 3D-FLAIR: without T2-contrast enhancement (Normal), with non-selective T2-inversion recovery (T2-IR), and two with non-selective T2 preparation IR (T2-prep). Read More

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Efficiency of a novel middle ear pressure device for intractable definite Meniere's disease and delayed endolymphatic hydrops after certification by the public health insurance system in Japan.

Acta Otolaryngol 2022 May 11;142(5):388-394. Epub 2022 May 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.

Background: Middle ear pressure therapy (MEPT) is effective in treating intractable vertigo in patients with definite Meniere's disease (MD) and delayed endolymphatic hydrops (DEH) refractory to conservative treatment. A novel middle ear pressure device, the EFET01, which requires no transtympanic ventilation tubes, was developed in Japan, approved by the Japanese Ministry of Health, Labour and Welfare, and has been used under Japanese national health insurance since September 2018.

Objectives: To examine short-term therapeutic effect of MEPT using the ETET01 compared with previous clinical trial results. Read More

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Endolymphatic Hydrop Phenotype in Familial Norrie Disease Caused by Large Fragment Deletion of .

Front Aging Neurosci 2022 18;14:771328. Epub 2022 Apr 18.

Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University, Cleveland, OH, United States.

Norrie disease (ND; OMIM 310600), a rare X-linked recessive genetic disorder, is characterized by congenital blindness and occasionally, sensorineural hearing loss, and developmental delay. The congenital blindness of ND patients is almost untreatable; thus, hearing is particularly important for them. However, the mechanism of hearing loss of ND patients is unclear, and no good treatment is available except wearing hearing-aid. Read More

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The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs.

Front Cell Neurosci 2022 11;16:836093. Epub 2022 Apr 11.

Department of Facial Plastic Reconstruction Surgery, Eye and ENT Hospital of Fudan University, Shanghai, China.

Background: Endolymphatic hydrops (EH) is considered as the pathological correlate of Menière's disease (MD) and cause of hearing loss. The mechanism of EH, remaining unrevealed, poses challenges for formalized clinical trials.

Objective: This study aims to investigate the development of hearing loss, as well as the effect of dehydration treatment on EH animal models. Read More

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Effectiveness of galvanic vestibular evoked myogenic potential for evaluation of Meniere's disease.

Braz J Otorhinolaryngol 2022 Feb 21. Epub 2022 Feb 21.

Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, China. Electronic address:

Objectives: Although the cause of Meniere's disease (MD) is not fully understood, endolymphatic hydrops is widely believed to be responsible for MD. Previous studies have used Air-Conducted Sound (ACS)-induced Vestibular Evoked Myogenic Potentials (VEMPs) to evaluate otolithic function in patients with MD. However, the use of Galvanic Vestibular Stimulation-VEMPs (GVS-VEMPs) with other vestibular tests in MD has been rare. Read More

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February 2022

Discrepancies in the caloric testing and video Head Impulse Test results in a case with bilateral lateral semicircular canal malformations.

Auris Nasus Larynx 2022 Apr 22. Epub 2022 Apr 22.

Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Lateral semicircular canal (LSCC) malformations represent one of the most common types of inner ear malformation. As many cases of LSCC malformations are asymptomatic, detailed vestibular functions in such cases remain unclear. We present a case with bilateral LSCC malformations for whom the function of each vestibular organ was evaluated by caloric testing, video Head Impulse Test (vHIT) and vestibular evoked myogenic potentials (VEMP). Read More

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A Perspective for Ménière's Disease: In Silico Investigations of Dexamethasone as a Direct Modulator of AQP2.

Biomolecules 2022 03 28;12(4). Epub 2022 Mar 28.

Structural Motility, Institut Curie, Paris Université Sciences et Lettres, Sorbonne Université, CNRS UMR144, F-75005 Paris, France.

Ménière's disease is a chronic illness characterized by intermittent episodes of vertigo associated with fluctuating sensorineural hearing loss, tinnitus and aural pressure. This pathology strongly correlates with a dilatation of the fluid compartment of the endolymph, so-called hydrops. Dexamethasone is one of the therapeutic approaches recommended when conventional antivertigo treatments have failed. Read More

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The value of vestibular evoked myogenic potential and electrocochleography in unexplained aural fullness.

Acta Otolaryngol 2022 Mar-Apr;142(3-4):225-228. Epub 2022 Apr 21.

Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Background: Unexplained aural fullness, after excluding external or middle ear diseases and vertigo, is not easily diagnosed.

Aim: The aim of this study is to determine the vestibular evoked myogenic potential (VEMP) and electrocochleography (ECochG) abnormal rates in patients with unexplained aural fullness, and analyzed the relationship between unexplained aural fullness and endolymphatic hydrops (EH).

Material And Methods: The VEMP and EcochG abnormal rates in 54 patients with unexplained aural fullness and 21 healthy volunteers, and the VEMP and EcochG abnormal rates in the four hearing loss groups were compared. Read More

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The Effect of Collagen Viscoelastoplasiticty on Reissner's Membrane Displacement: A Graphic Analysis.

Authors:
Daniel J Pender

J Int Adv Otol 2022 Mar;18(2):96-99

Department of Otolaryngology, Columbia University, New York City, USA.

Background: The aim of this study is to analyze the effect of collagen viscoelastoplasticity on the bulge displacement of Reissner's membrane that is observed in endolymphatic hydrops and Meniere's disease.

Methods: Viscoelastoplastic load-deformation characteristics for Reissner's membrane were based on a reported collagen polymer model of the cochleo-saccular membranes. The projected bulge displacements of Reissner's model membrane at key distention points were quantified trigonometrically and plotted graphically. Read More

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[Vertigo attacks plus ear sounds: What disease is behind it?]

Authors:
Frank Schmäl

MMW Fortschr Med 2022 04;164(7):24-25

Maria.Josef-Hospital, Zentrum für HNO, Lindenstraße 7, 48268, Greven, Germany.

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Association Between Meniere Disease and Migraine.

JAMA Otolaryngol Head Neck Surg 2022 05;148(5):457-464

Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea.

Importance: A connection between Meniere disease (MD) and migraine has been proposed, but the temporal association remains unknown.

Objective: To examine the bidirectional association of MD with migraine.

Design, Setting, And Participants: This case-control study included participants 40 years or older from the Korean National Health Insurance Service Health Screening Cohort from 2002 to 2015. Read More

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[Effect of Connexin on Cochlear Blood-Labyrinth Barrier in a Mouse Model of Endolymphatic Hydrops].

Sichuan Da Xue Xue Bao Yi Xue Ban 2022 Mar;53(2):291-296

Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To examine the expression of tight-junction connexin ZO-1 in the stria vascularis tissue of the cochlea by using spontaneous endolymphatic hydrops animal model constructed with gene mutant mice, and to analyze the dynamic changes of the gene mutant mice in pathology, imaging, and hearing function.

Methods: Male Hyp-Duk/Y mice with gene mutation were selected as the experimental group at three time points, 21 days post birth (P21), 90 days post birth (P90) and 120 days post birth (P120), and wild-type male mice of the same ages were selected as the control groups. The cochlear sections were HE-stained in order to observe whether endolymphatic hydrops was present or absent and to assess its severity. Read More

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[Dynamic changes of vestibular autorotation test in patients with unilateral vestibular dysfunction during rehabilitation].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Mar;57(3):270-275

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

To explore the dynamic changes of vestibular autorotation test (VAT) before and after vestibular rehabilitation treatment in patients with unilateral vestibular hypofunction (UVH). A retrospective study was carried out,48 patients who were diagnosed with UVH and under vestibular rehabilitation in department of otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, from January 2019 to January 2021 were enrolled. Among them, there were 21 males and 27 females, with an average age of 46. Read More

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Intratympanic gentamicin compared with placebo for Ménière's disease.

Medwave 2022 Mar 22;22(2):e8696. Epub 2022 Mar 22.

Proyecto Epistemonikos, Santiago, Chile; Departamento de Otorrinolaringología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction: Ménière's disease is a multifactorial disorder affecting the inner ear, characterized by episodes of spontaneous and recurrent vertigo, fluctuating hearing loss and tinnitus. Intratympanic gentamicin therapy has been used to reduce the intensity and frequency of attacks in intractable Ménière's disease, but it is associated with hearing loss. There is controversy regarding its efficacy and safety. Read More

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NaCl exposure results in increased expression and processing of IL-1β in Meniere's disease patients.

Sci Rep 2022 03 23;12(1):4957. Epub 2022 Mar 23.

The Feinstein Institutes for Medical Research, Manhasset, NY, USA.

Meniere's disease (MD) is a chronic disease that causes episodic vertigo, fluctuating hearing loss, and aural fullness, initially managed by dietary salt reduction, and use of diuretics. Our prior research in autoimmune inner ear disease (AIED) demonstrated that in peripheral blood mononuclear cell (PBMC) from corticosteroid-resistant AIED patients, increased production, processing and release of interleukin-1β (IL-1β) is observed and hearing could be improved with use of anakinra, an interleukin-1 receptor antagonist. We have further identified that in these AIED patients, IL-1β is uniquely processed to a 28 kDa pro-inflammatory product by caspase-7. Read More

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Vestibular migraine, demographic and clinical features of 415 patients: A multicenter study.

Clin Neurol Neurosurg 2022 04 8;215:107201. Epub 2022 Mar 8.

University of Health Sciences Izmir Tepecik Education and Research Hospital Department of Neurology, Izmir 35110, Turkey. Electronic address:

Objective: To evaluate demographic and clinical features of vestibular migraine (VM) patients METHODS: Four hundred fifteen patients with VM were evaluated by using a structured questionnaire in addition to clinical examination.

Results: The mean age of headache and vertigo onset was 25 years and 39 years, respectively. In 12. Read More

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