7,691 results match your criteria Endolymphatic Hydrops


Three-Dimensional Magnetic Resonance Imaging Reveals the Relationship Between the Control of Vertigo and Decreases in Endolymphatic Hydrops After Endolymphatic Sac Drainage With Steroids for Meniere's Disease.

Front Neurol 2019 4;10:46. Epub 2019 Feb 4.

Department of Otolaryngology- Head and Neck Surgery, Nara Medical University, Kashihara, Japan.

Meniere's disease is a common disease, that presents with recurrent vertigo and cochlear symptoms. The pathology of Meniere's disease was first reported to involve endolymphatic hydrops in 1938. The endolymphatic sac is thought to have a role to keep the hydrostatic pressure and endolymph homeostasis for the inner ear. Read More

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http://dx.doi.org/10.3389/fneur.2019.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369164PMC
February 2019

Sensorineural hearing loss in patients with vestibular schwannoma correlates with the presence of utricular hydrops as diagnosed on heavily T2-weighted MRI.

Diagn Interv Imaging 2019 Feb 14. Epub 2019 Feb 14.

Department of Neuroradiology, Rouen University Hospital, 76000 Rouen, France; Department of Neuroradiology and MRI, Grenoble Alpes University Hospital, SFR RMN neurosciences, 38000 Grenoble, France.

Purpose: The purpose of this study was to assess whether the volume of the vestibular endolymphatic space correlates with the degree of hearing loss using heavily T2-weighted fast imaging employing steady-state acquisition with cycle phase (FIESTA-C) MRI.

Materials And Methods: A total of 23 patients with vestibular schwannoma, as diagnosed on typical image findings, who underwent FIESTA-C MRI were included. There were 13 women and 10 men with a mean age of 63. Read More

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http://dx.doi.org/10.1016/j.diii.2019.01.006DOI Listing
February 2019

[Magnetic resonance imaging study of endolymphatic hydrops based on 3D-FLAIR sequence after single-dose intravenous gadolinium injection].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):333-337

Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

To investigate the visualization of endolymph in patients with otogenic vertigo by intravenous administration of single dose of gadolinium contrast agents and magnetic resonance three-dimensional fluid-attenuated inversion recovery sequence (3D-FLAIR MRI), and further assess the extent of endolymphatic hydrops. From Beijing Tongren Hospital of Capital Medical University between October 2017 and June 2018, 30 patients (16 males, 14 females) with unilateral otogenic vertigo were involved in this study, with the age of 30 to 68 years, mean age of (53±10) years. Eight hours after intravenous administration of single dose (0. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.003DOI Listing
January 2019

The Biomechanics of Lesion Formation in Endolymphatic Hydrops: Single and Double Hit Mechanisms.

Authors:
Daniel J Pender

Otol Neurotol 2019 Mar;40(3):398-403

College of Physicians and Surgeons, Columbia University, New York City, New York.

Background: The vestibular membranes of the cochlea and saccule are subject to two simultaneous constraints as they deform in endolymphatic hydrops. Boundary tethers impose a bulge-type constraint during pressure-induced transverse membrane displacement, while inherent elasticity imposes a stretch-type constraint during stress-induced longitudinal membrane distention.

Objective: The aim of this study is to reconcile the effect of these dual constraints on membrane deformation. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002149DOI Listing

[The subjective perception of the vertical-a valuable parameter for determination of peripheral vestibular disorder in Menière's disease in the chronic phase?]

HNO 2019 Feb 6. Epub 2019 Feb 6.

Klinik für Hals‑, Nasen- und Ohrenheilkunde, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität, Berlin Humboldt Universität zu Berlin and Berlin Institute of Health, Berlin, Deutschland.

The perception of verticality is mainly based on utricular afferent signals and central processing of the transmitted signals. However, there are also extracranial receptors that make a considerable contribution to the perception of verticality. With the subjective visual vertical (SVV) for the utricle and the subjective trunk vertical (STV), two different parameters are available that are not fully understood in terms of their response to physiologic and pathologic changes. Read More

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http://dx.doi.org/10.1007/s00106-019-0626-6DOI Listing
February 2019

The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Menière's disease on MRI.

Neuroradiology 2019 Feb 5. Epub 2019 Feb 5.

Department of Radiology, GZA Hospitals Antwerp, Oosterveldlaan 24, 2610, Wilrijk, Belgium.

Purpose: There is still a clinical-radiologic discrepancy in patients with Menière's disease (MD). Therefore, the purpose of this study was to investigate the reliability of current MRI endolymphatic hydrops (EH) criteria according to Baráth in a larger study population and the clinical utility of new imaging signs such as a supplementary fourth low-grade vestibular EH and the degree of perilymphatic enhancement (PE) in patients with Menière's disease (MD).

Methods: This retrospective study included 148 patients with probable or definite MD according to the 2015 American Academy of Otolaryngology, Head and Neck Surgery criteria who underwent a 4-h delayed intravenous Gd-enhanced 3D-FLAIR MRI between January 2015 and December 2016. Read More

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http://dx.doi.org/10.1007/s00234-019-02155-7DOI Listing
February 2019
5 Reads

Quantitative evaluation of endolymphatic hydrops with MRI through intravenous gadolinium administration and VEMP in unilateral definite Meniere's disease.

Eur Arch Otorhinolaryngol 2019 Jan 29. Epub 2019 Jan 29.

NHC Key Laboratory of Hearing Medicine, Department of Otolaryngology, Eye Ear Nose & Throat Hospital Shanghai, Fudan University, 83 Fenyang Rd, Shanghai, 200031, People's Republic of China.

Purpose: To help clinicians to further understand the significance of vestibular-evoked myogenic potential (VEMP) examinations to diagnose MD and the quantitative relationship between VEMP and MRI in assessing the location and degree of endolymphatic hydrops (EH) in definite Meniere's disease (MD) patients.

Methods: Fifty-six patients with unilateral definite MD participated in this study, which used MRIs through intravenous gadolinium administration (IV-Gd), audiometry, caloric tests and VEMP tests. The VEMP results of 26 healthy volunteers were used as a normal reference value. Read More

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http://dx.doi.org/10.1007/s00405-018-05267-7DOI Listing
January 2019

Vincamine exerts protective effect on spiral ganglion neurons in endolymphatic hydrops guinea pig models.

Am J Transl Res 2018 15;10(11):3650-3663. Epub 2018 Nov 15.

Shanghai University of TCM Shanghai 201203, China.

The aim of this study was to investigate the protective effects of vincamine in endolymphatic hydrops (ELH). After ELH guinea pigs treated by vincamine, the concentration of VAP in plasma, and the levels of cAMP, MDA, SOD, GSH-Px in right cochlea were measured using spectrophotometric method. The V2R, NMDAR1, p-NMDAR1, AQP2, p-AQP2, caspase3/9 and c-caspase3/9 expressions in right cochlea were detected using western blot analysis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291722PMC
November 2018
7 Reads

[Transient unilateral sudden hearing loss after spinal anesthesia].

Agri 2019 Jan;31(1):50-52

Department of Anesthesiology and Reanimation, Ordu State Hospital, Ordu,Turkey.

Hearing loss after spinal anesthesia is one of the rare complications. It has been suggested that low frequent hearing loss develops after the development of endolymphatic hydrops in the cochlea due to CSF escape after dural puncture. Hearing loss after nonotologic surgical procedures is very rare and usually can only be determined by audiometric evaluation. Read More

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http://dx.doi.org/10.5505/agri.2017.17136DOI Listing
January 2019
1 Read

Clinical features and management of Meniere's disease patients with drop attacks.

Eur Arch Otorhinolaryngol 2019 Jan 2. Epub 2019 Jan 2.

Department of Otology and Skull Base Surgery, Hearing Research Key Lab of Health Ministry of China, Eye and Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.

Purpose: The aims of the present study are to investigate the variations in clinical features, including medical history, hearing function, vestibular function, and degree of endolymphatic hydrops (EH), in Meniere's disease (MD) patients with and without drop attacks (DAs), and to examine the efficacy of intratympanic gentamicin (ITG) treatment in alleviating DAs.

Methods: In total, 177 unilateral definite MD patients, including 16 patients with DAs and 161 patients without DAs, were enrolled. The results of hearing test, vestibular-evoked myogenic potentials (VEMPs), and magnetic resonance imaging (MRI) were analyzed. Read More

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http://dx.doi.org/10.1007/s00405-018-5260-5DOI Listing
January 2019

Gadolinium-enhanced MRI reveals dynamic development of endolymphatic hydrops in Ménière's disease.

Braz J Otorhinolaryngol 2018 Dec 20. Epub 2018 Dec 20.

Shanghai East Hospital, Department of Otorhinolaryngology Shanghai, Shanghai, China.

Introduction: Meniere's disease is associated with impaired hearing, tinnitus, vertigo, and aural fullness. Many anatomical studies have suggested idiopathic endolymphatic hydrops as the pathological basis of Meniere's disease, which now can be visualized by using gadolinium -enhanced magnetic resonance imaging of the inner ear.

Objective: To investigate the development of endolymphatic hydrops in Meniere's disease by monitoring the vestibules and cochleae of affected patients. Read More

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http://dx.doi.org/10.1016/j.bjorl.2018.10.014DOI Listing
December 2018
5 Reads

[Optimization of delivering minimum Gd-DTPA at the posterior upper point on tympanic medial wall and hT2W-3D-FLAIR sequence for detecting endolymphatic hydrops].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;53(12):931-938

Department of Otorhinolaryngology Head and Neck Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.

To optimize delivery of gadolinium-diethylenetriamine pentaacetic acid(Gd-DTPA) at the posterior upper point on tympanic medial wall and heavily T2-weighted 3-dimensional fluid-attenuated inversion recovery (hT2W-3D-FLAIR) sequence, and to implement the technique of detecting endolymphatic hydrops using gadolinium-enhancement MRI. Thirteen patients with periphery vertigo, who visited Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Changhai Hospital during June and December of 2017, were enrolled in the study.0. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2018.12.011DOI Listing
December 2018

Clinical Features and Endolymphatic Hydrops in Patients With MRI Evidence of Hydrops.

Ann Otol Rhinol Laryngol 2018 Dec 17:3489418819551. Epub 2018 Dec 17.

1 ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China.

Objectives:: The purpose of this study was to investigate the correlation between grades of endolymphatic hydrops (ELH) and clinical characteristics and determine the detailed clinical characteristics of Ménière's disease (MD) patients with evidence of hydrops based on magnetic resonance imaging (MRI).

Methods:: One hundred ninety-eight MD patients (396 ears) with MRI evidence of hydrops were included. ELH grades were evaluated using the Nakashima grading standard. Read More

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http://journals.sagepub.com/doi/10.1177/0003489418819551
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http://dx.doi.org/10.1177/0003489418819551DOI Listing
December 2018
8 Reads

Diagnostic Value of the Magnetic Resonance Imaging With Intratympanic Gadolinium Administration (IT-Gd MRI) Versus Audio-Vestibular Tests in Menière's Disease: IT-Gd MRI Makes the Difference.

Otol Neurotol 2019 Mar;40(3):e225-e232

Albers-Schönberg Institute for Radiology in Hamburg, Germany.

Objective: Our aim was to evaluate the validity and reliability of clinically relevant tests in the diagnosis of Menière's disease (MD) according to the criteria formulated during 2015 as well as their efficacy in detecting endolymphatic hydrops (EH). The focus was on: three-dimensional fluid-attenuated inversion recovery-SPectral Attenuated Inversion Recovery (3D-FLAIR-SPAIR) sequences using 3 Tesla magnetic resonance imaging (3T MRI) performed 24 hours after intratympanic Gadolinium injection (IT-Gd) in comparison with the functional tests pure tone audiometry (PTA), caloric test, video head impulse test (vHIT), and cervical-vestibular-evoked-myogenic-potentials (cVEMP).

Study Design: Retrospective study. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002082DOI Listing

Three-Tesla magnetic resonance imaging of the vestibular endolymphatic space: A systematic qualitative description in healthy ears.

Eur J Radiol 2018 Dec 24;109:77-82. Epub 2018 Oct 24.

Neuroradiology Unit, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy; Postgraduate School of Radiodiagnostics, Università degli Studi di Milano, Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

Background And Purpose: A detailed knowledge of the normal Magnetic Resonance (MR) anatomy of the vestibular endolymphatic space (ES) could be useful to understand the linkage between endolymphatic hydrops (EH) and Ménière's disease (MD). Our aim was to describe the MR anatomy of the vestibular ES as depicted by MR imaging in healthy ears.

Methods: This report describes a single-center retrospective study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183037
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http://dx.doi.org/10.1016/j.ejrad.2018.10.023DOI Listing
December 2018
9 Reads

Magnetic resonance-based volumetric measurement of the endolymphatic space in patients with Meniere's disease and other endolymphatic hydrops-related diseases.

Auris Nasus Larynx 2018 Nov 29. Epub 2018 Nov 29.

Department of Otorhinolaryngology Head and Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara, Japan.

Objective: To employ magnetic resonance imaging (MRI) to measure the volume of the inner ear endolymphatic space (ELS) in patients with acute low-tone sensorineural hearing loss (ALHL), sudden deafness (SD), cochlear Meniere's disease (cMD), and unilateral MD (uMD) compared with control subjects (CS) with chronic rhinosinusitis.

Methods: Forty-one patients with ALHL, 82 with SD, 48 with cMD, 72 with uMD, and 47 CS participated in the study. With the exception of all uMD patients, none of the subjects had vertigo. Read More

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http://dx.doi.org/10.1016/j.anl.2018.11.008DOI Listing
November 2018
9 Reads

Change in endolymphatic hydrops 2 years after endolymphatic sac surgery evaluated by MRI.

Auris Nasus Larynx 2018 Nov 27. Epub 2018 Nov 27.

Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Objective: This study was performed to determine whether endolymphatic sac surgery improves vestibular and cochlear endolymphatic hydrops 2 years after sac surgery and to elucidate the relationship between the degree of improvement of endolymphatic hydrops and the changes in vertigo symptoms, the hearing level, and the summating potential/action potential ratio (-SP/AP ratio) by electrocochleography (ECochG) in patients with Ménière's disease (MD).

Methods: Twenty-one patients with unilateral MD who underwent sac surgery were included in this study. All patients underwent gadolinium-enhanced magnetic resonance imaging (Gd-MRI) before and 2 years after sac surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03858146183065
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http://dx.doi.org/10.1016/j.anl.2018.10.011DOI Listing
November 2018
19 Reads

Bilateral delayed endolymphatic hydrops evaluated by bilateral intratympanic injection of gadodiamide with 3T-MRI.

PLoS One 2018 5;13(12):e0206891. Epub 2018 Dec 5.

Department of Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan.

The purpose of this study was to assess the diagnostic performance of 3T MRI after intratympanic injection of gadodiamide for delayed endolymphatic hydrops (DEH), and assess the relationship between endolymphatic hydrops (ELH) and vestibular function in patients diagnosed with DEH and confirmed by 3T MRI. Nineteen patients clinically diagnosed with DEH (11 ipsilateral DEH, 8 contralateral DEH) participated in this study. Diluted gadodiamide was administered to the bilateral tympanic cavity by injection through the tympanic membrane. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206891PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281314PMC
December 2018
10 Reads

Vertical head impulse and caloric are complementary but react opposite to Meniere's disease hydrops.

Laryngoscope 2018 Dec 4. Epub 2018 Dec 4.

Department of Otolaryngology, University of Tokushima School of Medicine, Tokushima, Japan.

Objectives/hypothesis: Meniere's disease (MD) patients can show normal head impulses despite poor caloric test results. This study aimed to investigate the discrepancy in the vestibulo-ocular reflex (VOR) in MD patients and whether endolymphatic hydrops (EH) influence the VOR.

Study Design: Prospective, cross-sectional observational study. Read More

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http://dx.doi.org/10.1002/lary.27580DOI Listing
December 2018
15 Reads

Usefulness of Intravenous Gadolinium Inner Ear MR Imaging in Diagnosis of Ménière's Disease.

Sci Rep 2018 Dec 3;8(1):17562. Epub 2018 Dec 3.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

This study aimed to investigate the usefulness of the intravenous gadolinium enhanced inner ear magnetic resonance imaging (IV-Gd inner ear MRI) in diagnosing Ménière's disease(MD) and find a correlation between the degree of endolymphatic hydrops(EH) and the audiovestibular tests. Total 29 patients diagnosed with unilateral definite MD were enrolled. All patients underwent IV-Gd inner ear MRI and auditory and vestibular function tests such as pure tone audiometry (PTA), electrocochleography (ECoG), cervical vestibular evoked myogenic potential (cVEMP) and caloric test. Read More

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http://dx.doi.org/10.1038/s41598-018-35709-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277445PMC
December 2018
6 Reads

Secondary Endolymphatic Hydrops Associated With Spontaneous Intracranial Hypotension.

JAMA Otolaryngol Head Neck Surg 2018 Nov 21. Epub 2018 Nov 21.

Department of Otolaryngology-Head and Neck Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1001/jamaoto.2018.3073DOI Listing
November 2018

Imaging of Ménière Disease.

Neuroimaging Clin N Am 2019 Feb;29(1):19-28

Department of Radiology, GZA Hospitals Antwerp, Oosterveldlaan 24, Wilrijk 2610, Belgium.

Visualization of the morphologic substrate of Ménière disease, the endolymphatic hydrops, can be performed using noncontrast or contrast-enhanced MR imaging techniques. Noncontrast MR imaging uses a heavily T2-weighted sequence; however, its reproducibility remains to be confirmed. Contrast-enhanced MR imaging techniques mainly use a 3-dimensional fluid-attenuated inversion recovery sequence after intratympanic gadolinium administration or after a 4-hour delayed intravenous gadolinium administration. Read More

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http://dx.doi.org/10.1016/j.nic.2018.09.002DOI Listing
February 2019
11 Reads

Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter?

PLoS One 2018 15;13(11):e0207467. Epub 2018 Nov 15.

Department of Otorhinolaryngology, S.João Hospital Centre, Porto, Portugal.

Introduction: Middle ear application of gentamicin is a common medical treatment for uncontrolled Ménière's disease. The objective of the study was to evaluate the impact of endolymphatic hydrops on inner ear delivery.

Methods: Perilymph gentamicin concentrations and correlation with endolymphatic hydrops in an animal model were assessed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207467PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237362PMC
November 2018
13 Reads

The vestibular aqueduct sign: Magnetic resonance imaging can detect abnormalities in both ears of patients with unilateral Meniere's disease.

J Neuroradiol 2018 Nov 10. Epub 2018 Nov 10.

Department of neuroradiology and MRI, Grenoble university hospital, 38000 Grenoble France; University Grenoble Alpes, 38000 Grenoble, France; IRMaGe, inserm US 17, CNRS UMS 3552, 38000 Grenoble, France.

Background And Purpose: In patients with Meniere's disease (MD), saccular hydrops can only be studied by magnetic resonance imaging (MRI) at a late stage when the disease is already responsible for moderate to severe hearing loss. However, these patients may also present vestibular aqueduct (VA) abnormalities.

Materials And Methods: In this prospective study (38RC14. Read More

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http://dx.doi.org/10.1016/j.neurad.2018.10.003DOI Listing
November 2018
20 Reads

Tenotomy of the middle ear muscles : An unknown surgical approach in Meniere's disease.

Wien Klin Wochenschr 2019 Feb 12;131(3-4):87-91. Epub 2018 Nov 12.

Department of Otorhinolaryngology, Head and Neck Surgery, Rudolfstiftung Teaching Hospital, Juchgasse 25, 1030, Vienna, Austria.

Tenotomy of the tendon of the stapedius and tensor tympani muscles is a relatively unknown therapeutic procedure in Menière's disease. Widespread approaches include medicinal treatment with betahistine or diuretics as well as interventional procedures, such as intratympanic gentamicin or glucocorticoid injection, vestibular neurectomy, labyrinthectomy or endolymphatic sac surgery. The exact pathomechanism of this approach is not fully known. Read More

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http://dx.doi.org/10.1007/s00508-018-1405-1DOI Listing
February 2019
13 Reads

Signal Intensity of the Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agents: Strong Contrast Enhancement around the Vein of Labbe.

Magn Reson Med Sci 2018 Nov 9. Epub 2018 Nov 9.

Department of Otorhinolaryngology, Kamiiida Daiichi General Hospital.

Purpose: Since the first report on the deposition of gadolinium in the brain parenchyma after repeated intravenous administrations of gadolinium-based contrast agent GBCA (IV-GBCA), the mechanisms of penetration and retention are still remaining a hot topic of discussion and a target of investigation. We routinely obtain endolymphatic hydrops (EH) images at 4 h after IV administration of a single dose (SD) of GBCA (IV-SD-GBCA) using heavily T-weighted three-dimensional fluid-attenuated inversion recovery imaging (hTW-3D-FLAIR). Occasionally, we have encountered cases, which indicate high-signal intensity (SI) in the cerebrospinal fluid (CSF) surrounding the vein of Labbe. Read More

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http://dx.doi.org/10.2463/mrms.mp.2018-0043DOI Listing
November 2018

[The effectiveness of the intra-tympanic administration of methylprednisolone and gentamycin for the treatment of Meniere's disease].

Vestn Otorinolaringol 2018 ;83(5):17-20

MSCh 'Neftyanik' joint stock company, Tyumen, Russia.

Meniere's disease is an inner ear pathology characterized by periodic fits of systemic dizziness, fluctuating low-frequency sensorineural loss of hearing, stuffiness in the ear and tympanophonia. The objective of the present study was to evaluate the effectiveness of the intra-tympanic administration of methyl prednisolone in the combination with gentamycin used to treat the patients presenting with Meniere's disease. The study included 18 patients at the age varying from 18 to 70 years presenting with this condition. Read More

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http://dx.doi.org/10.17116/otorino20188305117DOI Listing
January 2018
6 Reads

Evaluation of the Effects of Chronic Kidney Disease and Hemodialysis on the Inner Ear Using Multifrequency Tympanometry.

J Int Adv Otol 2018 Dec;14(3):447-450

Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objectives: To evaluate the effects of chronic kidney disease (CKD) and hemodialysis (HD) on the inner ear using the G width (the width between the bimodal peaks of the conductance (G) tympanogram at 2,000 Hz), which reflects the inner ear pressure and/or the existence of endolymphatic hydrops.

Materials And Methods: We selected five patients (10 ears) from the patients with CKD who were hospitalized for creation of arteriovenous fistula prior to initiation of HD (non-HD group), and we selected seven patients (14 ears) from the patients with CKD who were undergoing HD (the HD group). As a control group, we selected 80 healthy individuals (160 ears); these were mainly the medical staff of the hospital. Read More

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http://www.advancedotology.org/eng/makale/1267/84/Full-Text
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http://dx.doi.org/10.5152/iao.2018.4736DOI Listing
December 2018
9 Reads

Autoimmunity and Otolaryngology Diseases.

J Immunol Res 2018;2018:2747904. Epub 2018 Oct 4.

Department Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1155/2018/2747904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193323PMC
February 2019

Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging.

Magn Reson Med Sci 2018 Nov 5. Epub 2018 Nov 5.

Department of Radiology, Nagoya University Graduate School of Medicine.

Purpose: It has been reported that intravenously administered gadolinium-based contrast agents (IV-GBCAs) leak into the cerebrospinal fluid (CSF) even in healthy subjects. The purpose of this study was to evaluate GBCA leakage from the cortical veins in patients with delayed imaging after IV-GBCA.

Materials And Methods: There are two parts of retrospective study. Read More

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http://dx.doi.org/10.2463/mrms.mp.2018-0053DOI Listing
November 2018

Inner ear pathologies impair sodium-regulated ion transport in Meniere's disease.

Acta Neuropathol 2019 Feb 2;137(2):343-357. Epub 2018 Nov 2.

Otopathology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Meniere's disease (MD), a syndromal inner ear disease, is commonly associated with a pathological accumulation of endolymphatic fluid in the inner ear, termed "idiopathic" endolymphatic hydrops (iEH). Although numerous precipitating/exacerbating factors have been proposed for MD, its etiology remains elusive. Here, using immunohistochemistry and in situ protein-protein interaction detection assays, we demonstrate mineralocorticoid-controlled sodium transport mechanisms in the epithelium of the extraosseous portion of the endolymphatic sac (eES) in the murine and human inner ears. Read More

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http://dx.doi.org/10.1007/s00401-018-1927-7DOI Listing
February 2019
12 Reads

Response of the inner ear to lipopolysaccharide introduced directly into scala media.

Hear Res 2018 Dec 17;370:105-112. Epub 2018 Oct 17.

The University of Sydney, Meniere's Research Laboratory, Australia.

In an attempt to develop an animal model of immune mediated Meniere's disease, we have injected lipopolysaccharide (LPS) directly into scala media of guinea pigs and monitored functional and morphological changes over a period of 6 weeks. Depending on the concentration of LPS, changes ranged from moderate-to-severe hearing loss and endolymphatic hydrops with minimal cellular infiltrate or fibrosis, to dense cellular infiltration that filled the scalae. Interestingly, higher concentrations of LPS not only induced severe cellular infiltration, hydrops, and hearing loss, but also a substantial enlargement of the endolymphatic duct and sac. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785955183036
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http://dx.doi.org/10.1016/j.heares.2018.10.007DOI Listing
December 2018
12 Reads

Supporting cell survival after cochlear implant surgery.

Laryngoscope 2019 Jan 16;129(1):E36-E40. Epub 2018 Oct 16.

Department of Otolaryngology-Head and Neck Surgery, Georgetown University Medical Center, Washington, DC.

Supporting cells (SCs) provide structure and maintain an environment that allows hair cells to receive and transmit signals in the auditory pathway. After insult to hair cells and ganglion cells, SCs respond by marking unsalvageable cells for death and maintain structural integrity. Although the histopathology after cochlear implantation has been described regarding hair cells and neural structures, surviving SCs in the implanted ear have not. Read More

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http://doi.wiley.com/10.1002/lary.27539
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http://dx.doi.org/10.1002/lary.27539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320269PMC
January 2019
9 Reads

Clinical manifestations of hydropic ear disease (Menière's).

Eur Arch Otorhinolaryngol 2019 Jan 10;276(1):27-40. Epub 2018 Oct 10.

Department of Otorhinolaryngology, University of Munich, Marchioninistr. 15, 81377, Munich, Germany.

Introduction: Hydropic ear disease, initially described by and named after Prosper Menière, is one of the most frequent vertigo disorders and one of the most frequent inner ear disorders. It is the syndrome of endolymphatic hydrops which until 2007 could be diagnostically confirmed only by post-mortem histology. In the past, various attempts to formulate clinical diagnostic criteria have been undertaken but were hampered by the inability to ascertain the diagnosis in living patients. Read More

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http://dx.doi.org/10.1007/s00405-018-5157-3DOI Listing
January 2019
16 Reads

Significance of Endolymphatic Hydrops Herniation Into the Semicircular Canals Detected on MRI.

Otol Neurotol 2018 Dec;39(10):1229-1234

Department of Otorhinolaryngology.

Objective: The objective of this study was to investigate the relationship between endolymphatic hydrops (EH) and hearing level or vestibular symptoms by focusing on EH herniation into the semicircular canal (SCC).

Study Design: Retrospective study.

Setting: University hospital. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002022DOI Listing
December 2018
8 Reads

[Menière's disease, endolymphatic hydrops and MRI].

Rev Med Suisse 2018 Oct;14(621):1734-1738

Service d'oto-rhino-laryngologie et chirurgie cervico-faciale, Département des neurosciences cliniques, HUG, 1211 Genève 14.

Menière's disease is characterized by episodic vertigo associated with fluctuating hearing loss, tinnitus and fullness of the ear on the affected side. Endolymphatic space enlargement - or endolymphatic hydrops (EH) - is a histological hallmark of the disease that does not explain all its clinical manifestations. Magnetic resonance imaging improvements now allow in vivo visualization of inner ear liquid spaces and appreciation of potential EH. Read More

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October 2018
7 Reads

In vivo Assessment of an Endolymphatic Hydrops Gradient Along the Cochlea in Patients With Menière's Disease by Magnetic Resonance Imaging-A Pilot Study.

Otol Neurotol 2018 Dec;39(10):e1091-e1099

Diagnostic and Interventional Neuroradiology.

Objective: To assess three strategies for evaluation and description of potential endolymphatic hydrops (EH) gradients along the cochlea in patients with Menière's disease.

Study Design: Prospective observational study.

Methods: Ten patients with definite Menière's disease revealed by magnetic resonance imaging were included in this prospectively conducted pilot study. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002016DOI Listing
December 2018
3 Reads

Clinical Characteristics of Bilateral Meniere's Disease in a Single Asian Ethnic Group.

Laryngoscope 2018 Oct 3. Epub 2018 Oct 3.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.

Objectives/hypothesis: To identify the clinical characteristics of patients with bilateral Meniere's disease (MD) in an Asian population.

Study Design: Cross-sectional retrospective study.

Methods: We compared the clinical features of bilateral MD (BMD) and unilateral MD (UMD) in 320 Asian patients with single ethnicity. Read More

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http://dx.doi.org/10.1002/lary.27423DOI Listing
October 2018
3 Reads

Association of Meniere's disease and retinal vascular calibre: a prospective observational study in China.

BMJ Open 2018 Oct 2;8(10):e022069. Epub 2018 Oct 2.

Department of Otolaryngology, Head and Neck Surgery, People's Hospital, Peking University, Beijing, China.

Objective: It is believed that Meniere's disease (MD) is associated with vascular disorders, but few studies have reported the relationship between retinal vascular disorders and MD. We evaluated and compared the retinal vascular calibres in patients with MD with healthy subjects matched for age, sex and vascular risk factors using retinal photographs to explore the association between MD and retinal vascular calibre.

Study Design: A prospective study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169750PMC
October 2018

Peripheral Vestibular System Histopathologic Changes following Head Injury without Temporal Bone Fracture.

Otolaryngol Head Neck Surg 2018 Oct 2:194599818795695. Epub 2018 Oct 2.

1 Department of Otolaryngology, Massachusetts Eye and Ear, Boston, Massachusetts, USA.

Objective Vestibular symptoms such as dizziness and vertigo are common after head injury and may be due to trauma to the peripheral vestibular system. The pathophysiology of peripheral vestibular symptoms following head injury without temporal bone (TB) fracture, however, is not well understood. Herein, we investigate the histopathology of the peripheral vestibular system of patients who sustained head injury without a TB fracture. Read More

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http://journals.sagepub.com/doi/10.1177/0194599818795695
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http://dx.doi.org/10.1177/0194599818795695DOI Listing
October 2018
1 Read

Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance.

Authors:
Sho Kanzaki

Molecules 2018 Sep 30;23(10). Epub 2018 Sep 30.

Department of Otolaryngology Head and Neck Surgery, School of Medicine, KEIO University, Tokyo 160-8582, Japan.

The inner ear contains many types of cell, including sensory hair cells and neurons. If these cells are damaged, they do not regenerate. Inner ear disorders have various etiologies. Read More

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http://dx.doi.org/10.3390/molecules23102507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222543PMC
September 2018
3 Reads

Salivary α-amylase levels in vertigo: Can it be an autonomic dysfunction?

Ear Nose Throat J 2018 Sep;97(9):278-282

Department of Emergency, Izmir Medicalpark Hospital, Izmir, Turkey.

We aim to demonstrate possible autonomic dysfunction based on salivary α-amylase measurements during and after the vertigo attacks associated with Ménière disease (MD) and benign paroxysmal positional vertigo (BPPV). Patients admitted to the emergency room with a diagnosis of vertigo attacks caused by either MD (n = 15) or BPPV (n = 9) constituted the study groups. The control group (n = 10) consisted of volunteer patients admitted to the emergency department with minor soft-tissue trauma. Read More

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September 2018
5 Reads

Simultaneous Presentation of Definite Vestibular Migraine and Definite Ménière's Disease: Overlapping Syndrome of Two Diseases.

Front Neurol 2018 10;9:749. Epub 2018 Sep 10.

Yoshimura ENT Clinic, Fujisawa, Japan.

To review the clinical records of patients that exhibited the clinical features of both vestibular migraine (VM) and Ménière's disease (MD) during each episodic vertigo attack and to discuss the possible pathophysiology of such combination of symptoms. Ten patients that were selected according to criteria based on a combination of the diagnostic criteria for definite MD and VM (9 females and one male, age: 22-54 years) were enrolled. They were required to show features of both diseases in each vertigo attack. Read More

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http://dx.doi.org/10.3389/fneur.2018.00749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139324PMC
September 2018
4 Reads

Audiovestibular Symptoms in Systemic Autoimmune Diseases.

J Immunol Res 2018 19;2018:5798103. Epub 2018 Aug 19.

Department Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.

Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Read More

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https://www.hindawi.com/journals/jir/2018/5798103/
Publisher Site
http://dx.doi.org/10.1155/2018/5798103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120292PMC
November 2018
17 Reads

Endolymphatic hydrops severity in magnetic resonance imaging evidences disparate vestibular test results.

Auris Nasus Larynx 2018 Sep 8. Epub 2018 Sep 8.

Department of Radiology, Clínica Universidad de Navarra, Universidad de Navarra, Spain.

Objectives: It has been suggested that in Ménière's disease (MD) a dissociated result in the caloric test (abnormal result) and video head-impulse test (normal result) probably indicates that hydrops affects the membranous labyrinth in the horizontal semicircular canal (HSC). The hypothesis in this study is that based on endolymphatic hydrops' cochleocentric progression, hydrops should also be more severe in the vestibule of these patients than in those for whom both tests are normal.

Methods: 22 consecutive patients with unilateral definite MD were included and classified as NN if both tests were normal or AN if the caloric test was abnormal. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03858146183058
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http://dx.doi.org/10.1016/j.anl.2018.08.014DOI Listing
September 2018
5 Reads

Evaluating Quality of Life in Patients With Meniere's Disease Treated as Migraine.

Ann Otol Rhinol Laryngol 2018 Dec 9;127(12):877-887. Epub 2018 Sep 9.

1 Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Irvine, CA, USA.

Objective:: To evaluate the change in quality of life (QOL) of patients with Meniere's disease (MD) after treatment with migraine prophylaxis therapy.

Methods:: Patients with definite MD were given the Meniere's Disease Outcomes Questionnaire-Retrospective (MDOQ-R) after migraine prophylactic therapy to assess QOL. Changes in physical, emotional, and social parameters affected by MD were calculated, along with a global pre- and posttreatment QOL scores. Read More

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http://dx.doi.org/10.1177/0003489418799107DOI Listing
December 2018
4 Reads

MR imaging of endolymphatic hydrops in Ménière's disease: not all that glitters is gold.

Acta Otorhinolaryngol Ital 2018 Aug;38(4):369-376

Neuroradiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Ménière's disease (MD) is a chronic condition characterised by fluctuating hearing loss, intermittent vertigo, tinnitus and aural fullness. Its anatomical and pathological counterpart is represented by endolymphatic hydrops (EH). Recent development and progress in magnetic resonance (MR) imaging techniques has enabled visualisation of EH in living human subjects using a 3 Tesla (T) scanner and gadolinium-based contrast-agent (GBCA) via intravenous (IV) or intra-tympanic (IT) administration. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146579PMC
http://dx.doi.org/10.14639/0392-100X-1986DOI Listing
August 2018
2 Reads

Delayed endolymphatic hydrops. Special emphasis on nystagmus associated with episodes and contribution of chemical labyrinthectomy.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Oct 29;135(5):321-326. Epub 2018 Aug 29.

Département d'ORL, centre hospitalier universitaire de Saint-Étienne, 42055 Saint-Étienne cedex 2, France. Electronic address:

Objectives: The main objective was to describe spontaneous nystagmus characteristics during an episode of delayed endolymphatic hydrops (DEH), including an initial vertical upbeating nystagmus in one patient. The secondary objective was to highlight the contribution of chemical labyrinthectomy.

Methods: Episodic vertigo after a prolonged period of time of sensorineural hearing loss (profound or total) in one ear characterized ipsilateral DEH and was associated with the development of hearing loss in the opposite ear in contralateral DEH. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.08.001DOI Listing
October 2018
8 Reads

Magnetic Resonance Imaging of Ménière's Disease After Intravenous Administration of Gadolinium.

Ann Otol Rhinol Laryngol 2018 Nov 29;127(11):777-782. Epub 2018 Aug 29.

1 Department of Otolaryngology-Head and Neck Surgery, Fudan University, Shanghai, China.

Objectives: A three-dimensional (3D) inversion-recovery (IR) sequence with real reconstruction (3D-real IR) sequence 4 hours after intravenous (IV) gadolinium injection has been used to visualize the endolymphatic hydrops (ELH) in Ménière's disease (MD). This study was designed to investigate the ELH characteristics in clinically diagnosed definite MD and to explore the pathology of MD with magnetic resonance imaging (MRI).

Methods: One hundred fifty-four patients with definite MD were included in this study. Read More

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http://dx.doi.org/10.1177/0003489418794699DOI Listing
November 2018
6 Reads

Saccular otoconia as a cause of Ménière's disease: hypothesis based on two theories.

Authors:
J Hornibrook

J Laryngol Otol 2018 Sep 28;132(9):771-774. Epub 2018 Aug 28.

Department of Otolaryngology - Head and Neck Surgery,Christchurch Hospital,University of Canterbury and University of Otago,Christchurch,New Zealand.

Background: The cause of Ménière's disease remains enigmatic after 156 years. Schuknecht's rupture and potassium intoxication theory of attacks was based on histological studies.

Objectives: This paper aimed to: present the most contemporary evidence indicating that ruptures do not usually occur, and discuss the possibility that detached saccular otoconia are the main cause of Ménière's disease; and to establish an unequivocal definition of the age of Ménière's disease onset. Read More

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http://dx.doi.org/10.1017/S0022215118001366DOI Listing
September 2018
30 Reads