7,964 results match your criteria Endolymphatic Hydrops


Cervical vestibular evoked myogenic potential with chirp sounds.

J Vestib Res 2020 Jun 27. Epub 2020 Jun 27.

Yoshimura ENT Clinic, Fujisawa, Japan.

Background: There are only a few reports concerning cervical vestibular evoked myogenic potential (cVEMP) using chirp sound, and clinical indications/advantages of it are still unclear.

Objective: To compare cVEMP using CE-chirp LS® with cVEMP using 500 Hz and 1000 Hz tone bursts (TB) and to investigate clinical indications/advantages of CE-chirp LS® for recording cVEMP.

Methods: Sixteen patients with vestibular disorders (2men and 14 women) (18∼62, mean 42. Read More

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http://dx.doi.org/10.3233/VES-200704DOI Listing

Endolymphatic hydrops mimicking obstructive Eustachian tube dysfunction: preliminary experience and literature review.

Eur Arch Otorhinolaryngol 2020 Jun 24. Epub 2020 Jun 24.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland.

Purpose: Aural fullness is a common symptom of middle ear diseases, most importantly Eustachian tube dysfunction (ETD). Yet, aural fullness may also be caused by inner ear disorders, such as hydropic ear diseases. Here, we report our experience with endolymphatic hydrops (EH) mimicking ETD. Read More

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http://dx.doi.org/10.1007/s00405-020-06139-9DOI Listing

A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig.

J Vis Exp 2020 Jun 4(160). Epub 2020 Jun 4.

Department of Otolaryngology, Head and Neck Surgery, Washington University School of Medicine in St. Louis;

Endolymphatic hydrops is an enlargement of scala media that is most often associated with Meniere's disease, though the pathophysiologic mechanism(s) remain unclear. In order to adequately study the attributes of endolymphatic hydrops, such as the origins of low-frequency hearing loss, a reliable model is needed. The guinea pig is a good model because it hears in the low-frequency regions that are putatively affected by endolymphatic hydrops. Read More

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http://dx.doi.org/10.3791/60597DOI Listing

Current status on researches of Meniere's disease: a review.

Acta Otolaryngol 2020 Jun 21:1-5. Epub 2020 Jun 21.

Ear Nose and Throat Patient Area, Trauma and Reparative Medicine Theme, Karolinska University Hospital, Stockholm, Sweden.

Meniere's disease (MD) is a complex and multifactorial inner ear disease. The etiology of MD is unclear. Significant progress had been made in diagnosis and treatment. Read More

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http://dx.doi.org/10.1080/00016489.2020.1776385DOI Listing

Contralesional subjective visual horizontal predicts endolymphatic hydrops.

Acta Otolaryngol 2020 Jun 18:1-5. Epub 2020 Jun 18.

Neurology Department, Royal Prince Alfred Hospital and Central Clinical School, University of Sydney, Sydney, Australia.

The subjective visual horizontal (SVH) is a test of utricular function that assesses conjugate ocular torsion which is a component of the ocular tilt reaction (OTR). In unilateral destructive peripheral vestibular lesions, the OTR and so the SVH tilt is usually ipsiversive. Our study aimed to profile the causes of a contraversive SVH tilt in patients with a confirmed unilateral peripheral vestibular deficit. Read More

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http://dx.doi.org/10.1080/00016489.2020.1774650DOI Listing

Endolymphatic Hydrops Secondary to Spontaneous Intracranial Hypotension.

Headache 2020 Jun 16. Epub 2020 Jun 16.

Department of Neuroradiology, Lariboisière University Hospital, Paris, France.

Background: Spontaneous intracranial hypotension may be associated with neuro-otological symptoms that might mimic Menière's disease.

Case Presentation: We report the case of a 53-year-old male presenting bi-frontal headache with recurrent spells of vertigo, left fluctuating hearing loss, and tinnitus. Dedicated brain and inner ear Magnetic Resonance Imaging, including a post-contrast 4 hours delayed FLAIR sequence, revealed typical signs of spontaneous intracranial hypotension associated with endolymphatic hydrops involving the left saccule and cochlea. Read More

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http://dx.doi.org/10.1111/head.13866DOI Listing

Vestibular Aging Process from 3D Physiological Imaging of the Membranous Labyrinth.

Sci Rep 2020 Jun 15;10(1):9618. Epub 2020 Jun 15.

National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, 152-8902, Japan.

There is no three-dimensional (3D) technique to study the microanatomical structures of the in vivo 3D vestibular membranous labyrinth. Recent two MRI methods using a contrast agent can only depict the low-resolution imaging of endolymphatic hydrops. Therefore, we provide the new precise volume rendering algorithms to create the in vivo 3D vestibular membranous labyrinth images from high-resolution temporal bone low-dose CT data. Read More

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http://dx.doi.org/10.1038/s41598-020-66520-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295805PMC

The vestibular aqueduct ossification on temporal bone CT: an old sign revisited to rule out the presence of endolymphatic hydrops in Menière's disease patients.

Eur Radiol 2020 Jun 15. Epub 2020 Jun 15.

Neuroradiology Unit, Department of Neuroradiology, Lariboisière University Hospital, 75010, Paris, France.

Objectives: Menière's disease (MD) is associated with endolymphatic hydrops (EH), which is an accumulation of excessive endolymphatic fluid in the inner ear. However, using temporal bone CT, lower visualization rates of the vestibular aqueduct (VA) in these patients have also been reported.

Methods: In this retrospective single-center imaging study, we have included 25 healthy subjects and 47 patients having a definite, probable, or possible clinical diagnosis of MD that underwent temporal bone CT and inner ear MRI performed 4 h after contrast media administration. Read More

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http://dx.doi.org/10.1007/s00330-020-06980-wDOI Listing

Detailed MR imaging assessment of endolymphatic hydrops in patients with SLC26A4 mutations.

Auris Nasus Larynx 2020 Jun 11. Epub 2020 Jun 11.

Department of Otolaryngology, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto City, 390-8621, Japan. Electronic address:

Objective: Mutations in SLC26A4 represent the second most common mutations in deafness patients. The majority of patients with SLC26A4 mutations have a large vestibular aqueduct (LVA). Recently, some reports showed the presence of endolymphatic hydrops (ELH) in patients with LVA on the basis of high-resolution enhanced 3T-MRI. Read More

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http://dx.doi.org/10.1016/j.anl.2020.05.018DOI Listing

Dissociation of Caloric and Video Head Impulse Tests in Patients With Delayed Endolymphatic Hydrops.

Front Neurol 2020 12;11:362. Epub 2020 May 12.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Delayed endolymphatic hydrops (DEH) represents a rare clinical entity characterized by intermittent vertigo attacks mimicking those of Ménière's disease (MD) in a patient with a prior sensorineural hearing loss. Some vestibular tests have been employed in patients with DEH. These tests provide useful diagnostic information and facilitate clinical decision-making. Read More

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http://dx.doi.org/10.3389/fneur.2020.00362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247804PMC

Dietary Restriction for The Treatment of Meniere's Disease.

Transl Med UniSa 2020 May 31;22:5-9. Epub 2020 May 31.

Department of Medicine and Surgery, University of Salerno, Salerno, Italy.

Meniere's disease (MD) is an idiopathic inner ear disorder characterized by spontaneous recurrent vertigo, fluctuating sensorineural hearing loss (SNHL), aural fullness and tinnitus. Endolymphatic hydrops (EH) of the inner ear is currently considered the pathophysiological mechanisms that underlies typical symptoms of MD. MD diagnosis is based on the criteria of the Baràny Society. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265917PMC

Spontaneous Intracranial Hypotension May Be an Under-recognized Cause of Endolymphatic Hydrops.

Otol Neurotol 2020 May 28. Epub 2020 May 28.

Department of Otolaryngology.

Objective: We describe three rare cases of spontaneous intracranial hypotension (SIH) presenting with symptoms of endolymphatic hydrops (EH) and perform a literature review to bring attention to a rare link between SIH and EH.

Patient: A 59-year-old female presented with postural headache, aural fullness, vertigo, hearing loss, and abnormal electrocochleography after being diagnosed with SIH by magnetic resonance imaging. The site of cerebrospinal fluid leak was identified in this individual. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002665DOI Listing

The round window sign: a sensitive sign to detect perilymphatic fistulae on delayed postcontrast 3D-FLAIR sequence.

Eur Radiol 2020 May 28. Epub 2020 May 28.

Otology and Oto-neurosurgery Department, Salengro Hospital, CHU Lille, 59037, Lille, France.

Objectives: The aim of this study is to assess the diagnostic performance of a new MR sign, named the round window sign (RWS), to diagnose perilymphatic fistula (PLF) in a population of patients with chronic cochleo-vestibular symptoms, classified as definite or probable Menière's disease (MD).

Methods: A total of 164 patients (mean age 52 ± 35 years) with chronic cochleo-vestibular symptoms underwent MRI, between 4 and 5 h after intravenous gadoteric acid injection (Dotarem®, 0.1 mmol/kg). Read More

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http://dx.doi.org/10.1007/s00330-020-06924-4DOI Listing

Comparison of the video head impulse test results with caloric test in patients with Meniere's disease and other vestibular disorders.

Acta Otolaryngol 2020 May 21:1-8. Epub 2020 May 21.

Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Nara, Japan.

The caloric test has been used to evaluate the semi-circular canal function for decades. In 2009, the video head impulse test (vHIT) was introduced, which can be used to evaluate the semi-circular canal function within a short time. Although both tests examine the semi-circular canal, the stimulation methods differ and it is unclear whether the vHIT is equivocal to the caloric test. Read More

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http://dx.doi.org/10.1080/00016489.2020.1766700DOI Listing

A Micro-CT and Synchrotron Imaging Study of the Human Endolymphatic Duct with Special Reference to Endolymph Outflow and Meniere's Disease.

Sci Rep 2020 May 19;10(1):8295. Epub 2020 May 19.

Department of Surgical Sciences, Head and Neck Surgery, section of Otolaryngology, Uppsala University Hospital, Departments of Otolaryngology, Uppsala University Hospital, SE-751 85, Uppsala, Sweden.

Meniere's disease remains enigmatic, and has no treatment with sufficient evidence. The characteristic histopathological finding is endolymphatic hydrops, suggesting either an overproduction or decreased reabsorption of endolymph in the human inner ear. This study presents the first analysis of the vascular plexus around the human endolymphatic duct using micro computed tomography and coherent synchrotron radiation with phase contrast imaging. Read More

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http://dx.doi.org/10.1038/s41598-020-65110-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237694PMC

Inner-Ear Disorders Presenting with Air-Bone Gaps: A Review.

J Int Adv Otol 2020 Apr;16(1):111-116

Department of Medicine and Surgery, University of Salerno, Salerno, Italy.

Air-bone gaps (ABGs) are commonly found in patients with conductive or mixed hearing loss generally due to outer- and/or middle-ear diseases such as otitis externa, tympanic membrane perforation, interruption or fixation of the ossicular chain, and chronic suppurative otitis media. ABGs can also be found in correlation with inner-ear disorders, such as endolymphatic hydrops, enlarged vestibular aqueduct syndrome, semicircular canal dehiscence, gusher syndrome, cochlear dehiscence, and Paget disease's as well cerebral vascular anomalies including dural arteriovenous fistula. The typical clinical presentation of inner-ear conditions or cerebral vascular anomalies causing ABGs includes audiological and vestibular symptoms like vertigo, oscillopsia, dizziness, imbalance, spinning sensation, pulsatile or continuous tinnitus, hyperacusis, autophony, auricular fullness, Tullio's phenomenon, and Hennebert's sign. Read More

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http://dx.doi.org/10.5152/iao.2020.7764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224429PMC
April 2020
0.128 Impact Factor

Computing Endolymph Hydrodynamics During Head Impulse Test on Normal and Hydropic Vestibular Labyrinth Models.

Front Neurol 2020 21;11:289. Epub 2020 Apr 21.

Vestibular Research Laboratory, School of Psychology, The University of Sydney, Sydney, NSW, Australia.

Build a biologic geometry based computational model to test the hypothesis that, in some circumstances, endolymphatic hydrops can mechanically cause enhanced eye velocity responses during clinical conditions of the head impulse test. Some recent clinical and experimental findings had suggested that enhanced eye velocity responses measured with the video head impulse test could not only be caused by recording artifacts or central disfunction but also could be directly caused by the mechanical effect of endolymphatic hydrops on horizontal semicircular canal receptor. Data from clinical video head impulse test was computed in three biologic-based geometry models governed by Navier-Stokes equations; six head impulses of incrementally increasing peak head velocity were computed in each one of the three different geometric models, depending on absence, canal or utricular hydrops. Read More

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http://dx.doi.org/10.3389/fneur.2020.00289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193182PMC

Different findings of morphological changes and functional decline in the vestibule and the semicircular canal in ipsilateral delayed endolymphatic hydrops.

Clin Neurophysiol 2020 Jul 23;131(7):1487-1494. Epub 2020 Apr 23.

Department of Otology and Skull Base Surgery, Eye Ear Nose & Throat Hospital, Fudan University, Shanghai, China; Shanghai Auditory Medical Center, Shanghai, China; Key Laboratory of Hearing Science, Ministry of Health, Shanghai, China; NHC Key Laboratory of Hearing Medicine (Fudan University), Shanghai 200031, China. Electronic address:

Objective: To elucidate the pathophysiological process by analyzing the correlation between morphological and functional changes in patients with delayed endolymphatic hydrops (DEH).

Methods: Twenty-nine patients diagnosed with DEH were enrolled in this retrospective study. All patients were assessed using the caloric test, cervical and ocular vestibular evoked myogenic potentials, and gadolinium-enhanced magnetic resonance imaging (MRI) of the inner ear. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.03.032DOI Listing
July 2020
3.097 Impact Factor

MR imaging and clinical characteristics of Lermoyez syndrome.

Acta Otolaryngol 2020 May 6:1-5. Epub 2020 May 6.

ENT Institute and Otorhinolaryngology Department, Eye and ENT Hospital, Fudan University of Eye and ENT Hospital, Shanghai, China.

Lermoyez syndrome (LS) is a rare auditory disorder, the details of LS remain unclear. To investigate the grades of endolymphatic hydrops (ELH) and clinical characteristics of clinically diagnosed LS. Nine patients with clinically diagnosed LS were included. Read More

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http://dx.doi.org/10.1080/00016489.2020.1751275DOI Listing

Enlarged vestibular aqueduct: Intraoperative electrocochleography findings during cochlear implantation.

Int J Pediatr Otorhinolaryngol 2020 Jul 24;134:110065. Epub 2020 Apr 24.

The Ohio State University, College of Medicine, Department of Otolaryngology- Head and Neck Surgery, Columbus, OH, USA; Nationwide Children's Hospital, Department of Otolaryngology-Head and Neck Surgery, Columbus, OH, USA.

Enlarged vestibular aqueduct (EVA) is the most frequent inner ear abnormality found on computed tomography in children with sensorineural hearing loss. The effects EVA abnormalities have on electrocochleography (ECochG) are unknown. Positive deflections in summation potential evoked by tone bursts were observed in 3/5 subjects, while a large negative deflection, similar to endolymphatic hydrops (EH), was observed for 2/5 subjects. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.110065DOI Listing

Therapeutic role of intravenous glycerol for Meniere's disease. Preliminary results.

Am J Otolaryngol 2020 Jul - Aug;41(4):102498. Epub 2020 Apr 21.

Department of Sense Organs, Sapienza University Rome, Rome, Italy; Center for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA. Electronic address:

Purpose: Osmotic diuretics such as glycerol are used for diagnostic purposes in patients with a suspect of Meniere's disease (MD). Scientific evidence in the animal model and in humans has shown that glycerol can induce a reduction in endolymphatic hydrops; however, its use for therapeutic purposes in MD has never been reported. The aim of this study was to evaluate the effectiveness on symptom control of intravenous glycerol in a sample of patients with definite unilateral MD not responsive to dietary restrictions. Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102498DOI Listing

Histopathological changes to the peripheral vestibular system following meningitic labyrinthitis.

Laryngoscope Investig Otolaryngol 2020 Apr 14;5(2):256-266. Epub 2020 Feb 14.

Department of Otolaryngology Massachusetts Eye and Ear Boston Massachusetts.

Objective: While cochlear ossification is a common sequalae of meningitic labyrinthitis, less is known about the effects of meningitis on peripheral vestibular end organs. Herein, we investigate histopathologic changes in the peripheral vestibular system and cochlea in patients with a history of meningitic labyrinthitis.

Methods: Temporal bone (TB) specimens from patients with a history of meningitis were evaluated and compared to age-matched controls. Read More

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http://dx.doi.org/10.1002/lio2.349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178454PMC

Automated measurement of hydrops ratio from MRI in patients with Ménière's disease using CNN-based segmentation.

Sci Rep 2020 Apr 24;10(1):7003. Epub 2020 Apr 24.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Ménière's Disease (MD) is difficult to diagnose and evaluate objectively over the course of treatment. Recently, several studies have reported MD diagnoses by MRI-based endolymphatic hydrops (EH) analysis. However, this method is time-consuming and complicated. Read More

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http://dx.doi.org/10.1038/s41598-020-63887-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181627PMC
April 2020
5.078 Impact Factor

Effects of endolymphatic hydrops on acoustic energy absorbance.

Acta Otolaryngol 2020 Apr 24:1-6. Epub 2020 Apr 24.

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

The presence of endolymphatic hydrops (EH) may cause hearing loss and affect the transmission of acoustic energy to the inner ear. Acoustic energy absorbance on wideband acoustic immittance (WAI) was evaluated, focusing especially on EH in the vestibule. A total of 32 ears from 16 patients who underwent 3-T magnetic resonance imaging (MRI) to evaluate the presence of EH were examined, retrospectively. Read More

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http://dx.doi.org/10.1080/00016489.2020.1754460DOI Listing

Acute sensorineural hearing loss in hemodialysis patients.

Acta Otolaryngol 2020 Apr 20:1-5. Epub 2020 Apr 20.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.

Approximately, 30-40% of patients experienced hearing loss under regular hemodialysis. This study reviewed our experience on treating acute hearing loss in patients under regular hemodialysis over the past two decades. Twenty-six patients having acute hearing loss under hemodialysis were divided into two groups based on their etiologies. Read More

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http://dx.doi.org/10.1080/00016489.2020.1745271DOI Listing

[Arginine vasopressin-aquaporin2 signal pathway and endolymphatic hydrops].

Authors:
L Y Jiang

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 04;55(4):426-431

Department of Acupuncture and Rehabilitation, Guangxing Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China.

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http://dx.doi.org/10.3760/cma.j.cn115330-20191219-00767DOI Listing

Depression in Ménière's disease: a systematic review and meta-analysis.

J Laryngol Otol 2020 Apr;134(4):293-301

Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, USA.

Background: Ménière's disease is a debilitating chronic peripheral vestibular disorder associated with psychiatric co-morbidities, notably depression.

Methods: Database searches were performed to identify studies that assessed depression in Ménière's disease. Metrics used to diagnose depression were extracted, along with the prevalence of depression in each study. Read More

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http://dx.doi.org/10.1017/S002221512000081XDOI Listing

Intracranial Distribution of Intravenously Administered Gadolinium-based Contrast Agent over a Period of 24 Hours: Evaluation with 3D-real IR Imaging and MR Fingerprinting.

Magn Reson Med Sci 2020 Apr 15. Epub 2020 Apr 15.

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine.

Purpose: To evaluate the feasibility for the detection of slight contrast effects after intravenous administration of single dose gadolinium-based contrast agent (IV-SD-GBCA), the time course of the GBCA distribution up to 24 h was examined in various fluid spaces and brain parenchyma using 3D-real IR imaging and MR fingerprinting (MRF).

Methods: Twenty-four patients with a suspicion of endolymphatic hydrops were scanned at pre-administration and at 10 min, 4 and 24 h post-IV-SD-GBCA. 3D-real IR images and MRF at the level of the internal auditory canal were obtained. Read More

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http://dx.doi.org/10.2463/mrms.mp.2020-0030DOI Listing

Clinical Practice Guideline: Ménière's Disease Executive Summary.

Otolaryngol Head Neck Surg 2020 04;162(4):415-434

American Academy of Otolaryngology-Head and Neck Surgery, Alexandria, Virginia, USA.

Objective: Ménière's disease (MD) is a clinical condition defined by spontaneous vertigo attacks (each lasting 20 minutes to 12 hours) with documented low- to midfrequency sensorineural hearing loss in the affected ear before, during, or after one of the episodes of vertigo. It also presents with fluctuating aural symptoms (hearing loss, tinnitus, or ear fullness) in the affected ear. The underlying etiology of MD is not completely clear, yet it has been associated with inner ear fluid volume increases, culminating in episodic ear symptoms (vertigo, fluctuating hearing loss, tinnitus, and aural fullness). Read More

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http://dx.doi.org/10.1177/0194599820909439DOI Listing

Plain Language Summary: Ménière's Disease.

Otolaryngol Head Neck Surg 2020 04;162(4):435-445

American Academy of Otolaryngology-Head and Neck Surgery Foundation, Alexandria, Virginia, USA.

This plain language summary explains Ménière's (pronounced men-yerz) disease (MD) to patients. The summary applies to patients aged 18 years and older with a suspected diagnosis of definite or probable MD. It is based on the 2020 "Clinical Practice Guideline: Ménière's Disease. Read More

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http://dx.doi.org/10.1177/0194599820909437DOI Listing

Clinical Practice Guideline: Ménière's Disease.

Otolaryngol Head Neck Surg 2020 04;162(2_suppl):S1-S55

American Academy of Otolaryngology-Head and Neck Surgery, Alexandria, Virginia, USA.

Objective: Ménière's disease (MD) is a clinical condition defined by spontaneous vertigo attacks (each lasting 20 minutes to 12 hours) with documented low- to midfrequency sensorineural hearing loss in the affected ear before, during, or after one of the episodes of vertigo. It also presents with fluctuating aural symptoms (hearing loss, tinnitus, or ear fullness) in the affected ear. The underlying etiology of MD is not completely clear, yet it has been associated with inner ear fluid (endolymph) volume increases, culminating in episodic ear symptoms (vertigo, fluctuating hearing loss, tinnitus, and aural fullness). Read More

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http://dx.doi.org/10.1177/0194599820909438DOI Listing

MRI evaluation of the endolymphatic space in otosclerosis and correlation with clinical findings.

Diagn Interv Imaging 2020 Apr 3. Epub 2020 Apr 3.

Department of Neuroradiology, Lariboisière University Hospital, Assistance Publique-Hopitaux de Paris, 75010 Paris, France; Université de Paris, Diderot-Paris 7, 75010 Paris, France. Electronic address:

Purpose: The purpose of this study was to investigate the clinical features of ears with otosclerosis and their correlation with endolymphatic hydrops and blood-labyrinth barrier (BLB) impairment on 3T magnetic resonance imaging (MRI).

Materials And Methods: This was a single-center retrospective imaging study. Thirty-nine ears from 29 patients (17 men, 12 women; mean age 52±12 [SD] years; range 27-74 years) with non-operated otosclerosis were included. Read More

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http://dx.doi.org/10.1016/j.diii.2020.03.009DOI Listing

Menière's disease patients improve specific posturographic parameters following diagnostic intratympanic injection.

Am J Otolaryngol 2020 Jul - Aug;41(4):102468. Epub 2020 Mar 24.

Department of Neuroscience, Imaging e Clinical Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.

Purpose: Evaluation of specific computerized posturographic parameters in patients with Menière's disease (MD) following the intratympanic injection of gadolinium, a contrast agent, used in radiological diagnosing.

Materials And Methods: We have observed 12 adult patients with unilateral Menière's Disease subjected to inner ear magnetic resonance imaging (MRI) examination after intratympanic gadolinium injection (ITG). The diagnoses have been performed according to the guidelines of the American Academy of otolaryngology. Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102468DOI Listing

Experimental Animal Models for Meniere's Disease: A Mini-Review.

J Audiol Otol 2020 Apr 31;24(2):53-60. Epub 2020 Mar 31.

School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, WA, Australia.

Several novel animal models that represent the pathophysiological process of endolymphatic hydrops (ELH) of Meniere's disease (MD) have been developed. Animal models are important to identify and characterize the pathophysiology of ELH and to corroborate molecular and genetic findings in humans. This review of the current animal models will be useful in understanding the pathophysiology of and developing proper treatments for MD. Read More

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http://dx.doi.org/10.7874/jao.2020.00115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141995PMC

Magnetic resonance imaging of Ménière's disease: early clinical experience in a UK centre.

J Laryngol Otol 2020 Apr 3;134(4):302-310. Epub 2020 Apr 3.

Department of Radiology, Guy's and St Thomas' Hospital, London, UK.

Background: Recent developments in magnetic resonance imaging have enabled demonstration of endolymphatic hydrops, and the clinical application of these imaging studies in Ménière's disease is being explored.

Objective: To evaluate our centre's experience to date of hydrops magnetic resonance imaging in patients with episodic vertigo.

Methods: Magnetic resonance imaging was performed using a high-resolution three-dimensional fluid-attenuated inversion recovery sequence on a 3 Tesla scanner at 4 hours following double-dose gadolinium administration. Read More

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http://dx.doi.org/10.1017/S0022215120000626DOI Listing

Comparison of Enhancement of the Vestibular Perilymph between Variable and Constant Flip Angle-Delayed 3D-FLAIR Sequences in Menière Disease.

AJNR Am J Neuroradiol 2020 04 19;41(4):706-711. Epub 2020 Mar 19.

From the Departments of Neuroradiology (S.N., J.-P.G., A.G., E.H., M.E.), and

Background And Purpose: Endolymphatic hydrops in patients with Menière disease relies on delayed postcontrast 3D-FLAIR sequences. The purpose of this study was to compare the degree of perilymphatic enhancement and the detection rate of endolymphatic hydrops using constant and variable flip angles sequences.

Materials And Methods: This was a retrospective study performed in 16 patients with Menière disease who underwent 3T MR imaging 4 hours after gadolinium injection using two 3D-FLAIR sequences with a constant flip angle at 140° for the first and a heavily-T2 variable flip angle for the second. Read More

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http://dx.doi.org/10.3174/ajnr.A6483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144642PMC

Effect of electroacupuncture on arginine vasopressin-induced endolymphatic hydrops.

J Tradit Chin Med 2019 04;39(2):221-228

Department of Acupuncture and Moxibustion, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.

Objective: To investigate the influence of electroacupuncture (EA) on experimentally induced endolymphatic hydrops (EH) in guinea pigs, and elucidate the association between the dehydrating effect of EA and changes in stria vascularis ultrastructure and expression of vasopressin type 2 receptor (V2R), cyclic adenosine monophosphate (cAMP), and aquaporin 2 (AQP2) in the endolymphatic sac (ES).

Methods: The EH model was established by intraperitoneal injection of arginine vasopressin (AVP). As a treatment, EA was delivered to Baihui (GV 20) and Tinggong (SI 19) acupoints, once daily for 10 consecutive days. Read More

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Contrast-Enhanced MRI Combined With the Glycerol Test Reveals the Heterogeneous Dynamics of Endolymphatic Hydrops in Patients With Menière's Disease.

J Magn Reson Imaging 2020 Mar 11. Epub 2020 Mar 11.

Department of Otorhinolaryngology - Head & Neck Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.

Background: The sensitivity of endolymphatic hydrops (EH) to the glycerol test varies in patients with Menière's disease (MD).

Purpose: To explore the features of EH and its glycerol-induced dynamics in MD.

Study Type: Case-control study. Read More

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http://dx.doi.org/10.1002/jmri.27127DOI Listing

Human Temporal Bone Study of Vestibular Histopathology in Cochlear Implant Patients With Cochlear Hydrops.

Otol Neurotol 2020 Jun;41(5):e607-e614

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California.

Hypothesis: Endolymphatic hydrops (EH) associated with cochlear implantation are associated with vestibular dysfunction.

Background: Vestibular dysfunction is a known risk after cochlear implantation (CI). CI has been shown to cause cochlear hydrops due to fibrosis surrounding the ductus reuniens. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002609DOI Listing

Bone Mineral Density in Patients Suffering from Ménière's Disease.

Audiol Neurootol 2020 21;25(3):158-163. Epub 2020 Feb 21.

Unit of Otoneurology, Lin Medical Center, Haifa, Israel.

Introduction: Previous studies have reported an association between reduced bone mineral density and the occurrence of benign paroxysmal positional vertigo, balance impairment, and saccular dysfunction. Furthermore, the results of recent animal studies have raised the possibility that vestibular dysfunction could affect bone remodeling and bone mass. The goal of the study was to compare bone mineral density of patients suffering from definite Ménière's disease to that of a matched control group. Read More

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http://dx.doi.org/10.1159/000506039DOI Listing
February 2020

[Diagnosis and outcome analysis of diseases characterized by recurrent low-frequency sensorineural deafness].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;34(2):106-112

Department of Otolaryngology Head and Neck Surgery,Chinese PLA Institute of Otolaryngology,National Clinical Research Center for Otolaryngologic Diseases,Key Lab of Hearing Impairment Science of Ministry of Education,Key Lab of Hearing Impairment Prevention and Treatment of Beijing,Chinese PLA General Hospital,Beijing,100853,China.

The aim of this study was to explore the clinical features, hearing prognosis and differential diagnosis of recurrent low frequency sensorineural hearing loss (RLFD) . The clinical characteristics, clinical manifestations, audiological examination and auxiliary examination of RLFD patients were retrospectively analyzed. We summarized clinical features, draw the pure tone audiometry curves, and analyze the diagnosis of RLFD. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2020.02.003DOI Listing
February 2020

[A review of endolymphatic sac-related surgeries and their possible mechanisms].

Authors:
B H He J Yang

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Jan;34(1):91-95

Endolymphatic sac-related surgeries are a series of effective procedures to treat patients with Ménière's disease. However, there is controversy since they were proposed in 1927. Although most studies have shown the effectiveness of endolymphatic decompression and endolymphatic shunting, the mechanisms of them are still unclear. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2020.01.023DOI Listing
January 2020

The Correlation Between Endolymphatic Hydrops and Clinical Features of Meniere Disease.

Laryngoscope 2020 Feb 21. Epub 2020 Feb 21.

Department of Radiology, First Hospital of China Medical University, Shenyang, People's Republic of China.

Objectives: The purpose of this study was to investigate the grades of endolymphatic hydrops determined by gadolinium-contrast magnetic resonance (MR) and correlation to the clinical features in patients with Meniere disease.

Study Design: Prospective study.

Methods: A total of 24 patients suffering from unilateral Meniere disease with either definite or probable clinical diagnosis were included. Read More

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http://dx.doi.org/10.1002/lary.28576DOI Listing
February 2020

MRI detection of endolymphatic hydrops in Meniere's disease in 8 minutes using MIIRMR and a 20-channel coil after targeted gadolinium delivery.

World J Otorhinolaryngol Head Neck Surg 2019 Dec 3;5(4):180-187. Epub 2020 Jan 3.

Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, China.

Background: Endolymphatic hydrops (EH) become visible in vertigo patients, particularly in those with Meniere's disease (MD), in vivo using gadolinium-enhanced MRI. However, the image quality is not satisfying after intravenous injection of gadolinium chelate (GdC), and occasional failure in GdC uptake has been noticed after traditional intratympanic injection. In the present report, targeted delivery of GdC and using a cost-effective MRI system to obtain high quality images of EH in only 8 min will be introduced. Read More

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http://dx.doi.org/10.1016/j.wjorl.2019.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015851PMC
December 2019

Authors' response to the letter on the article: "International consensus (ICON) on treatment of Ménière's disease".

Eur Ann Otorhinolaryngol Head Neck Dis 2020 05 10;137(3):239. Epub 2020 Feb 10.

Department of otolaryngology, Skull Base Surgery, CHU de Bordeaux, université de Bordeaux, 33000 Bordeaux, France.

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http://dx.doi.org/10.1016/j.anorl.2020.01.019DOI Listing

Rare Variants of Putative Candidate Genes Associated With Sporadic Meniere's Disease in East Asian Population.

Front Neurol 2019 22;10:1424. Epub 2020 Jan 22.

Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, South Korea.

The cause of Meniere's disease (MD) is unclear but likely involves genetic and environmental factors. The aim of this study was to investigate the genetic basis underlying MD by screening putative candidate genes for MD. Sixty-eight patients who met the diagnostic criteria for MD of the Barany Society were included. Read More

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http://dx.doi.org/10.3389/fneur.2019.01424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987317PMC
January 2020

Electrophysiological and inner ear MRI findings in patients with bilateral vestibulopathy.

Eur Arch Otorhinolaryngol 2020 May 8;277(5):1305-1314. Epub 2020 Feb 8.

Centre d'Explorations Fonctionnelles Otoneurologiques, Paris, France.

Purpose: Bilateral vestibulopathy (BV) is an uncommon disorder and the etiology remained idiopathic in most cases. Delayed 3D-FLAIR sequences have provided new insights into various inner ear diseases, allowing the evaluation of the endolymphatic space and the permeability of the blood-labyrinthine barrier (BLB). The aim of this study was to assess both the morphology of the endolymphatic space and the permeability of the BLB in patients with BV as evaluated by delayed 3D-FLAIR sequences. Read More

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http://dx.doi.org/10.1007/s00405-020-05829-8DOI Listing

Value of Endolymphatic Hydrops and Perilymph Signal Intensity in Suspected Ménière Disease.

AJNR Am J Neuroradiol 2020 03 6;41(3):529-534. Epub 2020 Feb 6.

From the Departments of Radiology (J.M.v.S., L.M.H.d.P., S.H.).

Background And Purpose: Ménière disease is characterized by endolymphatic hydrops, whereas perilymphatic enhancement on MR imaging has been suggested to be of additional value in diagnosing Ménière disease. This study evaluates the presence of endolymphatic hydrops and perilymphatic enhancement in patients with Ménière disease and with other vertigo-associated inner ear pathology.

Materials And Methods: A 3D-FLAIR sequence 4 hours after intravenous gadolinium injection was performed to visualize the endolymph and perilymph in 220 patients suspected of having Ménière disease. Read More

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http://dx.doi.org/10.3174/ajnr.A6410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077918PMC

Confirmation of Age-dependence in the Leakage of Contrast Medium around the Cortical Veins into Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agent.

Magn Reson Med Sci 2020 Feb 6. Epub 2020 Feb 6.

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine.

Purpose: It has been reported previously that intravenously administered gadolinium-based contrast agent (GBCA) leaks into the subarachnoid space around the cortical veins at 4 h after injection in all old people over 37 years, but not in younger people up to 37 years of age in 3D-real IR images. The purpose of this study was to investigate whether there was a strict threshold of 37 years of age for the leakage of the GBCA into the subarachnoid space.

Methods: The subjects included 190 patients, that were scanned for 3D-real IR images at 4 hours after intravenous injection of GBCA as a diagnostic test for endolymphatic hydrops. Read More

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http://dx.doi.org/10.2463/mrms.mp.2019-0182DOI Listing
February 2020