7,665 results match your criteria Endolymphatic Hydrops


Clinical Features and Endolymphatic Hydrops in Patients With MRI Evidence of Hydrops.

Ann Otol Rhinol Laryngol 2018 Dec 17:3489418819551. Epub 2018 Dec 17.

1 ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China.

Objectives:: The purpose of this study was to investigate the correlation between grades of endolymphatic hydrops (ELH) and clinical characteristics and determine the detailed clinical characteristics of Ménière's disease (MD) patients with evidence of hydrops based on magnetic resonance imaging (MRI).

Methods:: One hundred ninety-eight MD patients (396 ears) with MRI evidence of hydrops were included. ELH grades were evaluated using the Nakashima grading standard. Read More

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http://dx.doi.org/10.1177/0003489418819551DOI Listing
December 2018

Diagnostic Value of the Magnetic Resonance Imaging With Intratympanic Gadolinium Administration (IT-Gd MRI) Versus Audio-Vestibular Tests in Menière's Disease: IT-Gd MRI Makes the Difference.

Otol Neurotol 2018 Dec 13. Epub 2018 Dec 13.

Albers-Schönberg Institute for Radiology in Hamburg, Germany.

Objective: Our aim was to evaluate the validity and reliability of clinically relevant tests in the diagnosis of Menière's disease (MD) according to the criteria formulated during 2015 as well as their efficacy in detecting endolymphatic hydrops (EH). The focus was on: three-dimensional fluid-attenuated inversion recovery-SPectral Attenuated Inversion Recovery (3D-FLAIR-SPAIR) sequences using 3 Tesla magnetic resonance imaging (3T MRI) performed 24 hours after intratympanic Gadolinium injection (IT-Gd) in comparison with the functional tests pure tone audiometry (PTA), caloric test, video head impulse test (vHIT), and cervical-vestibular-evoked-myogenic-potentials (cVEMP).

Study Design: Retrospective study. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002082DOI Listing
December 2018

Three-Tesla magnetic resonance imaging of the vestibular endolymphatic space: A systematic qualitative description in healthy ears.

Eur J Radiol 2018 Dec 24;109:77-82. Epub 2018 Oct 24.

Neuroradiology Unit, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy; Postgraduate School of Radiodiagnostics, Università degli Studi di Milano, Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

Background And Purpose: A detailed knowledge of the normal Magnetic Resonance (MR) anatomy of the vestibular endolymphatic space (ES) could be useful to understand the linkage between endolymphatic hydrops (EH) and Ménière's disease (MD). Our aim was to describe the MR anatomy of the vestibular ES as depicted by MR imaging in healthy ears.

Methods: This report describes a single-center retrospective study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183037
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http://dx.doi.org/10.1016/j.ejrad.2018.10.023DOI Listing
December 2018
1 Read

Magnetic resonance-based volumetric measurement of the endolymphatic space in patients with Meniere's disease and other endolymphatic hydrops-related diseases.

Auris Nasus Larynx 2018 Nov 29. Epub 2018 Nov 29.

Department of Otorhinolaryngology Head and Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara, Japan.

Objective: To employ magnetic resonance imaging (MRI) to measure the volume of the inner ear endolymphatic space (ELS) in patients with acute low-tone sensorineural hearing loss (ALHL), sudden deafness (SD), cochlear Meniere's disease (cMD), and unilateral MD (uMD) compared with control subjects (CS) with chronic rhinosinusitis.

Methods: Forty-one patients with ALHL, 82 with SD, 48 with cMD, 72 with uMD, and 47 CS participated in the study. With the exception of all uMD patients, none of the subjects had vertigo. Read More

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http://dx.doi.org/10.1016/j.anl.2018.11.008DOI Listing
November 2018
3 Reads

Change in endolymphatic hydrops 2 years after endolymphatic sac surgery evaluated by MRI.

Auris Nasus Larynx 2018 Nov 27. Epub 2018 Nov 27.

Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Objective: This study was performed to determine whether endolymphatic sac surgery improves vestibular and cochlear endolymphatic hydrops 2 years after sac surgery and to elucidate the relationship between the degree of improvement of endolymphatic hydrops and the changes in vertigo symptoms, the hearing level, and the summating potential/action potential ratio (-SP/AP ratio) by electrocochleography (ECochG) in patients with Ménière's disease (MD).

Methods: Twenty-one patients with unilateral MD who underwent sac surgery were included in this study. All patients underwent gadolinium-enhanced magnetic resonance imaging (Gd-MRI) before and 2 years after sac surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03858146183065
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http://dx.doi.org/10.1016/j.anl.2018.10.011DOI Listing
November 2018
6 Reads

Bilateral delayed endolymphatic hydrops evaluated by bilateral intratympanic injection of gadodiamide with 3T-MRI.

PLoS One 2018 5;13(12):e0206891. Epub 2018 Dec 5.

Department of Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan.

The purpose of this study was to assess the diagnostic performance of 3T MRI after intratympanic injection of gadodiamide for delayed endolymphatic hydrops (DEH), and assess the relationship between endolymphatic hydrops (ELH) and vestibular function in patients diagnosed with DEH and confirmed by 3T MRI. Nineteen patients clinically diagnosed with DEH (11 ipsilateral DEH, 8 contralateral DEH) participated in this study. Diluted gadodiamide was administered to the bilateral tympanic cavity by injection through the tympanic membrane. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206891PLOS
December 2018
5 Reads

Vertical head impulse and caloric are complementary but react opposite to Meniere's disease hydrops.

Laryngoscope 2018 Dec 4. Epub 2018 Dec 4.

Department of Otolaryngology, University of Tokushima School of Medicine, Tokushima, Japan.

Objectives/hypothesis: Meniere's disease (MD) patients can show normal head impulses despite poor caloric test results. This study aimed to investigate the discrepancy in the vestibulo-ocular reflex (VOR) in MD patients and whether endolymphatic hydrops (EH) influence the VOR.

Study Design: Prospective, cross-sectional observational study. Read More

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http://dx.doi.org/10.1002/lary.27580DOI Listing
December 2018
6 Reads

Usefulness of Intravenous Gadolinium Inner Ear MR Imaging in Diagnosis of Ménière's Disease.

Sci Rep 2018 Dec 3;8(1):17562. Epub 2018 Dec 3.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

This study aimed to investigate the usefulness of the intravenous gadolinium enhanced inner ear magnetic resonance imaging (IV-Gd inner ear MRI) in diagnosing Ménière's disease(MD) and find a correlation between the degree of endolymphatic hydrops(EH) and the audiovestibular tests. Total 29 patients diagnosed with unilateral definite MD were enrolled. All patients underwent IV-Gd inner ear MRI and auditory and vestibular function tests such as pure tone audiometry (PTA), electrocochleography (ECoG), cervical vestibular evoked myogenic potential (cVEMP) and caloric test. Read More

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http://dx.doi.org/10.1038/s41598-018-35709-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277445PMC
December 2018
4 Reads

Secondary Endolymphatic Hydrops Associated With Spontaneous Intracranial Hypotension.

JAMA Otolaryngol Head Neck Surg 2018 Nov 21. Epub 2018 Nov 21.

Department of Otolaryngology-Head and Neck Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1001/jamaoto.2018.3073DOI Listing
November 2018

Imaging of Ménière Disease.

Neuroimaging Clin N Am 2019 Feb;29(1):19-28

Department of Radiology, GZA Hospitals Antwerp, Oosterveldlaan 24, Wilrijk 2610, Belgium.

Visualization of the morphologic substrate of Ménière disease, the endolymphatic hydrops, can be performed using noncontrast or contrast-enhanced MR imaging techniques. Noncontrast MR imaging uses a heavily T2-weighted sequence; however, its reproducibility remains to be confirmed. Contrast-enhanced MR imaging techniques mainly use a 3-dimensional fluid-attenuated inversion recovery sequence after intratympanic gadolinium administration or after a 4-hour delayed intravenous gadolinium administration. Read More

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http://dx.doi.org/10.1016/j.nic.2018.09.002DOI Listing
February 2019
6 Reads

Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter?

PLoS One 2018 15;13(11):e0207467. Epub 2018 Nov 15.

Department of Otorhinolaryngology, S.João Hospital Centre, Porto, Portugal.

Introduction: Middle ear application of gentamicin is a common medical treatment for uncontrolled Ménière's disease. The objective of the study was to evaluate the impact of endolymphatic hydrops on inner ear delivery.

Methods: Perilymph gentamicin concentrations and correlation with endolymphatic hydrops in an animal model were assessed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207467PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237362PMC
November 2018
8 Reads

The vestibular aqueduct sign: Magnetic resonance imaging can detect abnormalities in both ears of patients with unilateral Meniere's disease.

J Neuroradiol 2018 Nov 10. Epub 2018 Nov 10.

Department of neuroradiology and MRI, Grenoble university hospital, 38000 Grenoble France; University Grenoble Alpes, 38000 Grenoble, France; IRMaGe, inserm US 17, CNRS UMS 3552, 38000 Grenoble, France.

Background And Purpose: In patients with Meniere's disease (MD), saccular hydrops can only be studied by magnetic resonance imaging (MRI) at a late stage when the disease is already responsible for moderate to severe hearing loss. However, these patients may also present vestibular aqueduct (VA) abnormalities.

Materials And Methods: In this prospective study (38RC14. Read More

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http://dx.doi.org/10.1016/j.neurad.2018.10.003DOI Listing
November 2018
7 Reads

Tenotomy of the middle ear muscles : An unknown surgical approach in Meniere's disease.

Wien Klin Wochenschr 2018 Nov 12. Epub 2018 Nov 12.

Department of Otorhinolaryngology, Head and Neck Surgery, Rudolfstiftung Teaching Hospital, Juchgasse 25, 1030, Vienna, Austria.

Tenotomy of the tendon of the stapedius and tensor tympani muscles is a relatively unknown therapeutic procedure in Menière's disease. Widespread approaches include medicinal treatment with betahistine or diuretics as well as interventional procedures, such as intratympanic gentamicin or glucocorticoid injection, vestibular neurectomy, labyrinthectomy or endolymphatic sac surgery. The exact pathomechanism of this approach is not fully known. Read More

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http://dx.doi.org/10.1007/s00508-018-1405-1DOI Listing
November 2018
6 Reads

Signal Intensity of the Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agents: Strong Contrast Enhancement around the Vein of Labbe.

Magn Reson Med Sci 2018 Nov 9. Epub 2018 Nov 9.

Department of Otorhinolaryngology, Kamiiida Daiichi General Hospital.

Purpose: Since the first report on the deposition of gadolinium in the brain parenchyma after repeated intravenous administrations of gadolinium-based contrast agent GBCA (IV-GBCA), the mechanisms of penetration and retention are still remaining a hot topic of discussion and a target of investigation. We routinely obtain endolymphatic hydrops (EH) images at 4 h after IV administration of a single dose (SD) of GBCA (IV-SD-GBCA) using heavily T-weighted three-dimensional fluid-attenuated inversion recovery imaging (hTW-3D-FLAIR). Occasionally, we have encountered cases, which indicate high-signal intensity (SI) in the cerebrospinal fluid (CSF) surrounding the vein of Labbe. Read More

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http://dx.doi.org/10.2463/mrms.mp.2018-0043DOI Listing
November 2018

[The effectiveness of the intra-tympanic administration of methylprednisolone and gentamycin for the treatment of Meniere's disease].

Vestn Otorinolaringol 2018 ;83(5):17-20

MSCh 'Neftyanik' joint stock company, Tyumen, Russia.

Meniere's disease is an inner ear pathology characterized by periodic fits of systemic dizziness, fluctuating low-frequency sensorineural loss of hearing, stuffiness in the ear and tympanophonia. The objective of the present study was to evaluate the effectiveness of the intra-tympanic administration of methyl prednisolone in the combination with gentamycin used to treat the patients presenting with Meniere's disease. The study included 18 patients at the age varying from 18 to 70 years presenting with this condition. Read More

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http://dx.doi.org/10.17116/otorino20188305117DOI Listing
January 2018
3 Reads

Evaluation of the Effects of Chronic Kidney Disease and Hemodialysis on the Inner Ear Using Multifrequency Tympanometry.

J Int Adv Otol 2018 Nov 9. Epub 2018 Nov 9.

Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objectives: To evaluate the effects of chronic kidney disease (CKD) and hemodialysis (HD) on the inner ear using the G width (the width between the bimodal peaks of the conductance (G) tympanogram at 2,000 Hz), which reflects the inner ear pressure and/or the existence of endolymphatic hydrops.

Materials And Methods: We selected five patients (10 ears) from the patients with CKD who were hospitalized for creation of arteriovenous fistula prior to initiation of HD (non-HD group), and we selected seven patients (14 ears) from the patients with CKD who were undergoing HD (the HD group). As a control group, we selected 80 healthy individuals (160 ears); these were mainly the medical staff of the hospital. Read More

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http://www.advancedotology.org/eng/makale/1267/84/Full-Text
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http://dx.doi.org/10.5152/iao.2018.4736DOI Listing
November 2018
5 Reads

Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging.

Magn Reson Med Sci 2018 Nov 5. Epub 2018 Nov 5.

Department of Radiology, Nagoya University Graduate School of Medicine.

Purpose: It has been reported that intravenously administered gadolinium-based contrast agents (IV-GBCAs) leak into the cerebrospinal fluid (CSF) even in healthy subjects. The purpose of this study was to evaluate GBCA leakage from the cortical veins in patients with delayed imaging after IV-GBCA.

Materials And Methods: There are two parts of retrospective study. Read More

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http://dx.doi.org/10.2463/mrms.mp.2018-0053DOI Listing
November 2018

Inner ear pathologies impair sodium-regulated ion transport in Meniere's disease.

Acta Neuropathol 2018 Nov 2. Epub 2018 Nov 2.

Otopathology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Meniere's disease (MD), a syndromal inner ear disease, is commonly associated with a pathological accumulation of endolymphatic fluid in the inner ear, termed "idiopathic" endolymphatic hydrops (iEH). Although numerous precipitating/exacerbating factors have been proposed for MD, its etiology remains elusive. Here, using immunohistochemistry and in situ protein-protein interaction detection assays, we demonstrate mineralocorticoid-controlled sodium transport mechanisms in the epithelium of the extraosseous portion of the endolymphatic sac (eES) in the murine and human inner ears. Read More

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http://dx.doi.org/10.1007/s00401-018-1927-7DOI Listing
November 2018
7 Reads

Response of the inner ear to lipopolysaccharide introduced directly into scala media.

Hear Res 2018 Dec 17;370:105-112. Epub 2018 Oct 17.

The University of Sydney, Meniere's Research Laboratory, Australia.

In an attempt to develop an animal model of immune mediated Meniere's disease, we have injected lipopolysaccharide (LPS) directly into scala media of guinea pigs and monitored functional and morphological changes over a period of 6 weeks. Depending on the concentration of LPS, changes ranged from moderate-to-severe hearing loss and endolymphatic hydrops with minimal cellular infiltrate or fibrosis, to dense cellular infiltration that filled the scalae. Interestingly, higher concentrations of LPS not only induced severe cellular infiltration, hydrops, and hearing loss, but also a substantial enlargement of the endolymphatic duct and sac. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785955183036
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http://dx.doi.org/10.1016/j.heares.2018.10.007DOI Listing
December 2018
6 Reads

Supporting cell survival after cochlear implant surgery.

Laryngoscope 2018 Oct 16. Epub 2018 Oct 16.

Department of Otolaryngology-Head and Neck Surgery, Georgetown University Medical Center, Washington, DC.

Supporting cells (SCs) provide structure and maintain an environment that allows hair cells to receive and transmit signals in the auditory pathway. After insult to hair cells and ganglion cells, SCs respond by marking unsalvageable cells for death and maintain structural integrity. Although the histopathology after cochlear implantation has been described regarding hair cells and neural structures, surviving SCs in the implanted ear have not. Read More

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http://doi.wiley.com/10.1002/lary.27539
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http://dx.doi.org/10.1002/lary.27539DOI Listing
October 2018
4 Reads

Clinical manifestations of hydropic ear disease (Menière's).

Eur Arch Otorhinolaryngol 2018 Oct 10. Epub 2018 Oct 10.

Department of Otorhinolaryngology, University of Munich, Marchioninistr. 15, 81377, Munich, Germany.

Introduction: Hydropic ear disease, initially described by and named after Prosper Menière, is one of the most frequent vertigo disorders and one of the most frequent inner ear disorders. It is the syndrome of endolymphatic hydrops which until 2007 could be diagnostically confirmed only by post-mortem histology. In the past, various attempts to formulate clinical diagnostic criteria have been undertaken but were hampered by the inability to ascertain the diagnosis in living patients. Read More

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http://dx.doi.org/10.1007/s00405-018-5157-3DOI Listing
October 2018
12 Reads

Significance of Endolymphatic Hydrops Herniation Into the Semicircular Canals Detected on MRI.

Otol Neurotol 2018 Dec;39(10):1229-1234

Department of Otorhinolaryngology.

Objective: The objective of this study was to investigate the relationship between endolymphatic hydrops (EH) and hearing level or vestibular symptoms by focusing on EH herniation into the semicircular canal (SCC).

Study Design: Retrospective study.

Setting: University hospital. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002022DOI Listing
December 2018
4 Reads

[Menière's disease, endolymphatic hydrops and MRI].

Rev Med Suisse 2018 Oct;14(621):1734-1738

Service d'oto-rhino-laryngologie et chirurgie cervico-faciale, Département des neurosciences cliniques, HUG, 1211 Genève 14.

Menière's disease is characterized by episodic vertigo associated with fluctuating hearing loss, tinnitus and fullness of the ear on the affected side. Endolymphatic space enlargement - or endolymphatic hydrops (EH) - is a histological hallmark of the disease that does not explain all its clinical manifestations. Magnetic resonance imaging improvements now allow in vivo visualization of inner ear liquid spaces and appreciation of potential EH. Read More

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October 2018
7 Reads

In vivo Assessment of an Endolymphatic Hydrops Gradient Along the Cochlea in Patients With Menière's Disease by Magnetic Resonance Imaging-A Pilot Study.

Otol Neurotol 2018 Dec;39(10):e1091-e1099

Diagnostic and Interventional Neuroradiology.

Objective: To assess three strategies for evaluation and description of potential endolymphatic hydrops (EH) gradients along the cochlea in patients with Menière's disease.

Study Design: Prospective observational study.

Methods: Ten patients with definite Menière's disease revealed by magnetic resonance imaging were included in this prospectively conducted pilot study. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002016DOI Listing
December 2018
2 Reads

Clinical Characteristics of Bilateral Meniere's Disease in a Single Asian Ethnic Group.

Laryngoscope 2018 Oct 3. Epub 2018 Oct 3.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.

Objectives/hypothesis: To identify the clinical characteristics of patients with bilateral Meniere's disease (MD) in an Asian population.

Study Design: Cross-sectional retrospective study.

Methods: We compared the clinical features of bilateral MD (BMD) and unilateral MD (UMD) in 320 Asian patients with single ethnicity. Read More

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http://dx.doi.org/10.1002/lary.27423DOI Listing
October 2018
1 Read

Association of Meniere's disease and retinal vascular calibre: a prospective observational study in China.

BMJ Open 2018 Oct 2;8(10):e022069. Epub 2018 Oct 2.

Department of Otolaryngology, Head and Neck Surgery, People's Hospital, Peking University, Beijing, China.

Objective: It is believed that Meniere's disease (MD) is associated with vascular disorders, but few studies have reported the relationship between retinal vascular disorders and MD. We evaluated and compared the retinal vascular calibres in patients with MD with healthy subjects matched for age, sex and vascular risk factors using retinal photographs to explore the association between MD and retinal vascular calibre.

Study Design: A prospective study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169750PMC
October 2018

Peripheral Vestibular System Histopathologic Changes following Head Injury without Temporal Bone Fracture.

Otolaryngol Head Neck Surg 2018 Oct 2:194599818795695. Epub 2018 Oct 2.

1 Department of Otolaryngology, Massachusetts Eye and Ear, Boston, Massachusetts, USA.

Objective Vestibular symptoms such as dizziness and vertigo are common after head injury and may be due to trauma to the peripheral vestibular system. The pathophysiology of peripheral vestibular symptoms following head injury without temporal bone (TB) fracture, however, is not well understood. Herein, we investigate the histopathology of the peripheral vestibular system of patients who sustained head injury without a TB fracture. Read More

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http://journals.sagepub.com/doi/10.1177/0194599818795695
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http://dx.doi.org/10.1177/0194599818795695DOI Listing
October 2018
1 Read

Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance.

Authors:
Sho Kanzaki

Molecules 2018 Sep 30;23(10). Epub 2018 Sep 30.

Department of Otolaryngology Head and Neck Surgery, School of Medicine, KEIO University, Tokyo 160-8582, Japan.

The inner ear contains many types of cell, including sensory hair cells and neurons. If these cells are damaged, they do not regenerate. Inner ear disorders have various etiologies. Read More

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http://dx.doi.org/10.3390/molecules23102507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222543PMC
September 2018
2 Reads

Simultaneous Presentation of Definite Vestibular Migraine and Definite Ménière's Disease: Overlapping Syndrome of Two Diseases.

Front Neurol 2018 10;9:749. Epub 2018 Sep 10.

Yoshimura ENT Clinic, Fujisawa, Japan.

To review the clinical records of patients that exhibited the clinical features of both vestibular migraine (VM) and Ménière's disease (MD) during each episodic vertigo attack and to discuss the possible pathophysiology of such combination of symptoms. Ten patients that were selected according to criteria based on a combination of the diagnostic criteria for definite MD and VM (9 females and one male, age: 22-54 years) were enrolled. They were required to show features of both diseases in each vertigo attack. Read More

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http://dx.doi.org/10.3389/fneur.2018.00749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139324PMC
September 2018
1 Read

Audiovestibular Symptoms in Systemic Autoimmune Diseases.

J Immunol Res 2018 19;2018:5798103. Epub 2018 Aug 19.

Department Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.

Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Read More

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https://www.hindawi.com/journals/jir/2018/5798103/
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http://dx.doi.org/10.1155/2018/5798103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120292PMC
November 2018
8 Reads

Endolymphatic hydrops severity in magnetic resonance imaging evidences disparate vestibular test results.

Auris Nasus Larynx 2018 Sep 8. Epub 2018 Sep 8.

Department of Radiology, Clínica Universidad de Navarra, Universidad de Navarra, Spain.

Objectives: It has been suggested that in Ménière's disease (MD) a dissociated result in the caloric test (abnormal result) and video head-impulse test (normal result) probably indicates that hydrops affects the membranous labyrinth in the horizontal semicircular canal (HSC). The hypothesis in this study is that based on endolymphatic hydrops' cochleocentric progression, hydrops should also be more severe in the vestibule of these patients than in those for whom both tests are normal.

Methods: 22 consecutive patients with unilateral definite MD were included and classified as NN if both tests were normal or AN if the caloric test was abnormal. Read More

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http://dx.doi.org/10.1016/j.anl.2018.08.014DOI Listing
September 2018
2 Reads

Evaluating Quality of Life in Patients With Meniere's Disease Treated as Migraine.

Ann Otol Rhinol Laryngol 2018 Dec 9;127(12):877-887. Epub 2018 Sep 9.

1 Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Irvine, CA, USA.

Objective:: To evaluate the change in quality of life (QOL) of patients with Meniere's disease (MD) after treatment with migraine prophylaxis therapy.

Methods:: Patients with definite MD were given the Meniere's Disease Outcomes Questionnaire-Retrospective (MDOQ-R) after migraine prophylactic therapy to assess QOL. Changes in physical, emotional, and social parameters affected by MD were calculated, along with a global pre- and posttreatment QOL scores. Read More

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http://dx.doi.org/10.1177/0003489418799107DOI Listing
December 2018
1 Read

MR imaging of endolymphatic hydrops in Ménière's disease: not all that glitters is gold.

Acta Otorhinolaryngol Ital 2018 Aug;38(4):369-376

Neuroradiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Ménière's disease (MD) is a chronic condition characterised by fluctuating hearing loss, intermittent vertigo, tinnitus and aural fullness. Its anatomical and pathological counterpart is represented by endolymphatic hydrops (EH). Recent development and progress in magnetic resonance (MR) imaging techniques has enabled visualisation of EH in living human subjects using a 3 Tesla (T) scanner and gadolinium-based contrast-agent (GBCA) via intravenous (IV) or intra-tympanic (IT) administration. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146579PMC
http://dx.doi.org/10.14639/0392-100X-1986DOI Listing
August 2018
1 Read

Delayed endolymphatic hydrops. Special emphasis on nystagmus associated with episodes and contribution of chemical labyrinthectomy.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Oct 29;135(5):321-326. Epub 2018 Aug 29.

Département d'ORL, centre hospitalier universitaire de Saint-Étienne, 42055 Saint-Étienne cedex 2, France. Electronic address:

Objectives: The main objective was to describe spontaneous nystagmus characteristics during an episode of delayed endolymphatic hydrops (DEH), including an initial vertical upbeating nystagmus in one patient. The secondary objective was to highlight the contribution of chemical labyrinthectomy.

Methods: Episodic vertigo after a prolonged period of time of sensorineural hearing loss (profound or total) in one ear characterized ipsilateral DEH and was associated with the development of hearing loss in the opposite ear in contralateral DEH. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.08.001DOI Listing
October 2018
8 Reads

Magnetic Resonance Imaging of Ménière's Disease After Intravenous Administration of Gadolinium.

Ann Otol Rhinol Laryngol 2018 Nov 29;127(11):777-782. Epub 2018 Aug 29.

1 Department of Otolaryngology-Head and Neck Surgery, Fudan University, Shanghai, China.

Objectives: A three-dimensional (3D) inversion-recovery (IR) sequence with real reconstruction (3D-real IR) sequence 4 hours after intravenous (IV) gadolinium injection has been used to visualize the endolymphatic hydrops (ELH) in Ménière's disease (MD). This study was designed to investigate the ELH characteristics in clinically diagnosed definite MD and to explore the pathology of MD with magnetic resonance imaging (MRI).

Methods: One hundred fifty-four patients with definite MD were included in this study. Read More

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http://dx.doi.org/10.1177/0003489418794699DOI Listing
November 2018
5 Reads

Saccular otoconia as a cause of Ménière's disease: hypothesis based on two theories.

Authors:
J Hornibrook

J Laryngol Otol 2018 Sep 28;132(9):771-774. Epub 2018 Aug 28.

Department of Otolaryngology - Head and Neck Surgery,Christchurch Hospital,University of Canterbury and University of Otago,Christchurch,New Zealand.

Background: The cause of Ménière's disease remains enigmatic after 156 years. Schuknecht's rupture and potassium intoxication theory of attacks was based on histological studies.

Objectives: This paper aimed to: present the most contemporary evidence indicating that ruptures do not usually occur, and discuss the possibility that detached saccular otoconia are the main cause of Ménière's disease; and to establish an unequivocal definition of the age of Ménière's disease onset. Read More

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http://dx.doi.org/10.1017/S0022215118001366DOI Listing
September 2018
14 Reads

Recent and Frequent Vertigo Attacks Produce Negative Findings on Furosemide-Loading Vestibular Evoked Myogenic Potential Testing in Meniere's Disease.

Front Neurol 2018 3;9:636. Epub 2018 Aug 3.

Department of Otolaryngology, Kindai University, Osakasayama, Japan.

The peak-to-peak amplitude of the p13-n23 wave in cervical vestibular evoked myogenic potential can increase after furosemide administration in patients with Meniere's disease [furosemide-loading VEMP (FVEMP) testing]. The examination is used to test for the presence of endolymphatic hydrops; we investigated factors that may influence the results. Forty-two subjects (23 males and 19 females, aged 24-70 years) with unilateral definite Meniere's disease who underwent FVEMP testing were retrospectively studied. Read More

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http://dx.doi.org/10.3389/fneur.2018.00636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085477PMC
August 2018
9 Reads

[Postoperative anxiety and its relationship with life quality in patients with Ménière's diseases].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jun;43(6):662-667

Department of Otolaryngology Head and Neck Surgery, Civil Aviation General Hospital, Beijing 100123, China.

Objective: To investigate the postoperative anxiety and its relationship with life quality in patients with Ménière's diseases.
 Methods: A total of 68 patients with Ménière's disease, who received the treatment of endolymphatic sac decompression from 2010 to 2016, were enrolled. They finished two scales (the self-rating anxiety scale and the quality of life questionnaire for endolymphatic sac decompression of Ménière's disease) by snail mail. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.06.014DOI Listing
June 2018
4 Reads

Idiopathic benign paroxysmal positional vertigo with persistent vertigo/dizziness sensation is associated with latent canal paresis, endolymphatic hydrops, and osteoporosis.

Auris Nasus Larynx 2018 Jul 2. Epub 2018 Jul 2.

Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara-city, Nara, Japan.

Objective: The aim of the present study was to examine the association of neuro-otological examination, blood test, and scoring questionnaire data with treatment-resistant intractability in idiopathic benign paroxysmal positional vertigo (BPPV) patients.

Methods: We experienced 1520 successive vertigo/dizziness patients at the Vertigo/Dizziness Center in Nara Medical University during May 2014 to April 2018. Six hundred and eleven patients were diagnosed as BPPV (611/1520; 40. Read More

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http://dx.doi.org/10.1016/j.anl.2018.05.010DOI Listing
July 2018
1 Read

White matter lesions in magnetic resonance imaging of the brain in 56 patients with visual vertigo.

J Laryngol Otol 2018 Jun;132(6):550-553

Department of Otolaryngology,Sheffield Teaching Hospitals,University of Sheffield,UK.

Background: Visual vertigo is defined as a condition in which there is worsening or triggering of vestibular symptoms in certain visual environments. Previous studies have associated visual vertigo with an increased prevalence of underlying white matter lesions on brain imaging.

Method: This study evaluated the magnetic resonance imaging scans of the brain from a cohort of patients with visual vertigo, and compared the outcomes to an age- and gender-matched group of healthy volunteers. Read More

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https://www.cambridge.org/core/product/identifier/S002221511
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http://dx.doi.org/10.1017/S0022215118000701DOI Listing
June 2018
10 Reads

Suspensory Tethers and Critical Point Membrane Displacement in Endolymphatic Hydrops.

Authors:
Daniel J Pender

Int Arch Otorhinolaryngol 2018 Jul 25;22(3):214-219. Epub 2017 Jul 25.

Department of Otolaryngology, Columbia University, New York City, New York, United States.

 Grossly displaced membranes are characteristic of endolymphatic hydrops. The process whereby physiological membrane displacement becomes pathological may be mediated by stress, but the membrane biomechanics underlying this transition are unclear.  This study seeks to determine the role of suspensory tethers during pressure-induced membrane displacement in the generation of the membranous lesions seen in this disease entity using a biomechanical model approach. Read More

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http://dx.doi.org/10.1055/s-0037-1604474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033593PMC

In vivo assay of the potential gadolinium-induced toxicity for sensory hair cells using a zebrafish animal model.

J Appl Toxicol 2018 Nov 29;38(11):1398-1404. Epub 2018 Jun 29.

Department of Otorhinolaryngology - Head and Neck Surgery, Korea University College of Medicine, Korea University Ansan Hospital, Seoul, Republic of Korea.

Recently, intratympanic injection of gadolinium-based contrast agent (GdC) is growing in use to visualize the endolymphatic hydrops. Although GdC has been quite safely used over 20 years through intravenous injection, the biological influence of GdC on sensory hair cells needs to be thoroughly assessed for wider clinical application of it through intratympanic injection. In this in vivo experimental study, the summated number of sensory hair cells (SO1, SO2, O1 and OC1 neuromasts) showed a steep decrease in the group exposed to 10% and 20% GdC (35. Read More

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http://dx.doi.org/10.1002/jat.3656DOI Listing
November 2018
4 Reads

Exploring Optimal Stimulus Frequency Ratio for Measurement of the Quadratic f2-f1 Distortion Product Otoacoustic Emission in Humans.

J Speech Lang Hear Res 2018 Jul;61(7):1794-1806

Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL.

Purpose: Distortion product otoacoustic emissions (DPOAEs) are a by-product of active cochlear processes that lead to the compressive nonlinearity of healthy ears. The most commonly studied emission is at the frequency 2f1-f2, but there has been recent interest in using the quadratic distortion product at the frequency f2-f1 to detect cochleopathies including endolymphatic hydrops. Before the DPOAE at f2-f1 can be applied clinically in any capacity, optimal stimulus parameters for its elicitation must be established. Read More

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http://dx.doi.org/10.1044/2018_JSLHR-H-17-0349DOI Listing
July 2018
8 Reads

Vestibular sensory functional status of cochlear implanted ears versus non-implanted ears in bilateral profound deaf adults.

Rom J Morphol Embryol 2018 ;59(1):105-112

Department of Otorhinolaryngology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania; Department of Otorhinolaryngology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania;

Patients with hearing loss who underwent cochlear implantation can present symptomatic or asymptomatic vestibular damages earlier or later after the surgery. The vestibular permanent lesions could be acute, produced by surgical trauma or could be progressive due to local morphological changes made by the presence of the portelectrode in the inner ear (fibrosis related, ossification, basilar membrane distortion, endolymphatic hydrops). Besides histopathological findings in inner ear of cochlear implanted patients, the vestibular permanent damages could be found by assessment of clinical vestibular status. Read More

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October 2018
9 Reads

Normative data for TM electrocochleography measures.

J Otol 2017 Jun 12;12(2):68-73. Epub 2017 May 12.

University of Kansas Medical Center, Kansas City, KS 66160, USA.

Objective: Establish normative data for tympanic electrocochleography (TM ECochG) parameters in normal hearing adults without Ménière's disease's (MD) symptoms. Describe TM ECochG variables that help to distinguish normal from MD ears.

Material And Methods: We enrolled 100 subjects (N = 200 ears), 59 females, aged between 19 and 71 years from 09/2010 to 04/2014. Read More

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http://dx.doi.org/10.1016/j.joto.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963457PMC
June 2017
6 Reads

Contralateral Hearing Loss After Resection of Vestibular Schwannoma in a Patient with Neurofibromatosis 2: Case Report and Literature Review.

World Neurosurg 2018 Sep 12;117:74-79. Epub 2018 Jun 12.

Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

Background: Resection of a vestibular schwannoma may result in facial paralysis and hearing loss on the side of the tumor. We evaluated clinical, audiologic, and intraoperative events and radiologic parameters in a case of contralateral side sensorineural hearing loss. We also performed a literature search using PubMed. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.05.245DOI Listing
September 2018
11 Reads

Otopathologic Changes in the Cochlea following Head Injury without Temporal Bone Fracture.

Otolaryngol Head Neck Surg 2018 Sep 12;159(3):526-534. Epub 2018 Jun 12.

1 Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.

Objective Hearing loss following temporal bone (TB) fracture may result from direct transection of the middle and inner ear. The pathophysiology of hearing loss due to head injury without TB fracture, however, is not well understood. Few reports describe otopathologic findings. Read More

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http://dx.doi.org/10.1177/0194599818769861DOI Listing
September 2018
3 Reads

Intratympanic gadolinium magnetic resonance imaging supports the role of endolymphatic hydrops in the pathogenesis of immune-mediated inner-ear disease.

J Laryngol Otol 2018 Jun 11;132(6):554-559. Epub 2018 Jun 11.

Department of Otolaryngology,Hospital Universitario Puerta de Hierro,Universidad Autónoma de Madrid,Spain.

Objective: To evaluate the presence of endolymphatic hydrops in patients with immune-mediated inner-ear disease.

Methods: The presence of endolymphatic hydrops was prospectively evaluated in 17 patients clinically diagnosed with secondary (n = 5) or primary (n = 12) immune-mediated inner-ear disease, who attended the ENT department of a tertiary care centre for evaluation or treatment over the previous year. All patients underwent magnetic resonance imaging of the temporal bone. Read More

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http://dx.doi.org/10.1017/S0022215118000749DOI Listing
June 2018
1 Read

Visual vertigo: Vertigo of oculomotor origin.

Authors:
Seong Chin

Med Hypotheses 2018 Jul 3;116:84-95. Epub 2018 May 3.

Advocate Lutheran General Hospital, Department of Medicine, 1775 Dempster Street, Park Ridge, Illinois 60068, USA. Electronic address:

Since Róbert Bárány proposed his hypothesis on vestibulo-ocular reflex (VOR), dizziness associated with vertigo has been interpreted as being vestibular in origin. However, there have been many contradictory findings showing modulations of VOR, which have caused confusion as to VOR's role and accuracy. Further, there seems to be an influence of VOR when the anatomical inner ear structures are congenitally absent. Read More

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http://dx.doi.org/10.1016/j.mehy.2018.04.025DOI Listing