2,913 results match your criteria Endokrynologia Polska[Journal]


The value of Free Androgen Index depends on the phenotype of polycystic ovary syndrome, one centre experience.

Endokrynol Pol 2019 Apr 2. Epub 2019 Apr 2.

Department of Endocrinological Gynecology and Gynecology, Jagiellonian University Medical College, Kraków, Poland, ul. Kopernika 23, Kraków, 31-501 Kraków, Poland.

Introduction: The free androgen index (FAI) values differ among patients with polycystic ovarian syndrome, however the differences are not fully understood and known.

Aim: The aim of the study was to evaluate FAI in women with polycystic ovary syndrome (PCOS) in regard to the phenotype of the PCOS and insulin resistance status.

Materials And Methods: Anthropometric, hormonal and biochemical parameters were assessed in three hundred and twelve women with PCOS recruited. Read More

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http://dx.doi.org/10.5603/EP.a2019.0017DOI Listing
April 2019
4 Reads

Increased IL-35 in the circulation of patients with Graves' disease.

Endokrynol Pol 2019 Apr 2. Epub 2019 Apr 2.

Shanghai Pudong New District Zhoupu Hospital.

Background: The aim of this study was to explore the potential role of IL-35 in Graves' disease(GD).

Methods: A total of 142 GD patients including 80 newly onset patients, 52 refractory patients and 10 remission patients and 70 normal controls(NCs) were recruited. The messenger RNA (mRNA) expressions of P35 and Epstein-Barr-virus-induced gene 3 (Ebi3) were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.5603/EP.a2019.0018DOI Listing
April 2019
5 Reads

The effect of biotin interference on the results of blood hormone assays.

Endokrynol Pol 2019 ;70(1):102-121

Department of Endocrinology, Centre of Postgraduate Medical Education Bielański Hospital, Warsaw, Poland.

Approximately 70% of medical decisions are made based on results of laboratory investigations. Immunochemical methods are used most commonly in routine laboratory diagnostics of endocrine disorders. Those methods are limited by susceptibility of the immunochemical reaction to various interferences. Read More

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http://dx.doi.org/10.5603/EP.a2018.0084DOI Listing
January 2019
1 Read

Is our treatment in type 1 diabetes mellitus (insulin therapy models, metabolic control) optimal for preventing cardiovascular autonomic neuropathy?

Endokrynol Pol 2019 Mar 7. Epub 2019 Mar 7.

Katedra i Klinika Chorób Metabolicznych, Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie, Poland.

Introduction: Long-term poor metabolic control promotes the occurrence of microvascular complications, such cardiovascular autonomic neuropathy and atherogenic hyperlipidaemia, which translates into increased mortality in patients with type 1 diabetes (T1DM).

Aims: To assess the prevalence of cardiovascular autonomic neuropathy (CAN) in patients with T1DM in relation to treatment method (continuous subcutaneous insulin infusion (CSII) versus multiple daily injections using pens (MDI)) and lipid control.

Material And Methods: The study group comprised 93 adults (60 women, 33 men), median age 31, with T1DM being treated in a local clinical centre in 2011-2015. Read More

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http://dx.doi.org/10.5603/EP.a2019.0011DOI Listing
March 2019
3 Reads

Effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status.

Endokrynol Pol 2019 Mar 7. Epub 2019 Mar 7.

Hitit University, Faculty of Medicine, Department of Gynecology and Obstetrics.

Introduction: Granulin (GRN) is an adipokine with proinflammatory features and plays important role in glucose metabolism and insulin resistance pathogenesis. It has been reported that granulin precursors were localized in developing follicles in animal studies. The purpose of this study was to evaluate the association of granulin levels with anthropometric features, glucose metabolism and ovarian reserve. Read More

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http://dx.doi.org/10.5603/EP.a2019.0012DOI Listing
March 2019
2 Reads

Influence of the reclassification of NIFTP as a uncertain tumor on risk of malignancy for the diagnostic categories according to the Bethesda System for Reporting Thyroid Cytopathology.

Endokrynol Pol 2019 Mar 7. Epub 2019 Mar 7.

Klinika Endokrynologii, Świętokrzyskie Centrum Onkologii, Kielce, Poland.

Purpose: The noninvasive encapsulated, follicular variant of papillary thyroid carcinoma was reclassified as Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP). The exclusion of NIFTP from the group of malignant tumors decreases the risk of malignancy (RoM) as defined by the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). The aim of the present study was to evaluate the RoM for each category in TBSRTC with and without exclusion of NIFTP from the tally of malignancies. Read More

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http://dx.doi.org/10.5603/EP.a2019.0008DOI Listing
March 2019
1 Read

Association of pro-inflammatory cytokines with QCT measured bone mineral density and its gender difference in Chinese population.

Endokrynol Pol 2019 Mar 7. Epub 2019 Mar 7.

Introduction: The primary objective of this study was to explore the association of pro-inflammatory cytokines with quantitative computed tomography (QCT) measured bone mineral density (BMD) and its sexual difference in a Chinese population.

Methods: In a cross-sectional study, a total of 85 participants aged 48-85 years were recruited and classified into three groups: normal bone mass with BMD>120 mg/cm3, osteopenia with BMD 80-120 mg/cm3 and osteoporosis with BMD<80 mg/cm3. ANOVA analysis and multivariable ordinal logistic regression was used to estimate the associations of interest. Read More

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http://dx.doi.org/10.5603/EP.a2019.0014DOI Listing
March 2019
1 Read

CARDIOMETABOLIC RISK FACTORS IN YOUNG WOMEN WITH MACROPROLACTINEMIA.

Endokrynol Pol 2019 Mar 7. Epub 2019 Mar 7.

Medical University of Silesia - Depratment of Internal Medicine and Clinical Pharmacology, Medykow 18, 40-752 Katowice, Poland.

Introduction: The predominance of high molecular weight forms of prolactin in plasma is referred to as macroprolactinemia. Unlike monomeric hyperprolactinemia, no previous study has investigated cardiometabolic risk factors in subjects with elevated macroprolactin content.

Material And Methods: We studied two age-, weight-, and blood pressure-matched groups of premenopausal women: 11 women with macroprolactinemia and 11 women with prolactin levels within the reference range. Read More

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http://dx.doi.org/10.5603/EP.a2019.0013DOI Listing
March 2019
7 Reads

Capecitabine and temozolomide combination for treatment of high-grade well-differentiated neuroendocrine tumour and poorly-differentiated neuroendocrine carcinoma. Retrospective analysis.

Endokrynol Pol 2019 Mar 7. Epub 2019 Mar 7.

Medical University of Silesia, Katowice, Poland.

Introduction: Many retrospective studies confirmed that capecitabine combined with temozolomide is effective in treatment of neuroendocrine neoplasm. Most of studies focused on grade 1 and grade 2 neuroendocrine tumours, mainly of pancreas origin. There are limited data regarding efficacy capecitabine with temozolomide in grade 3 neuroendocrine tumours. Read More

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http://dx.doi.org/10.5603/EP.a2019.0010DOI Listing
March 2019
3 Reads

Diagnostics and treatment of acromegaly - updated recommendations of the Polish Society of Endocrinology.

Endokrynol Pol 2019 ;70(1):2-18

Department of Endocrinology and Metabolic Disorders, Medical University, Lodz, Poland.

Acromegaly is a rare disease caused by excessive production of growth hormone (GH), typically by a pituitary tumour. The diagnosis is usually delayed, and patients frequently develop various complications that cause premature mortality. In patients with hypertension, heart failure, diabetes, and arthropathies that are not age-specific, attention should be paid to signs of acromegaly. Read More

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http://dx.doi.org/10.5603/EP.a2018.0093DOI Listing
January 2019
2 Reads

The real costs of acromegaly: analysis of different therapies.

Endokrynol Pol 2019 ;70(1):74-85

Deptartment of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Wroclaw, Poland.

Acromegaly is a rare, chronic condition caused by growth hormone (GH) overproduction, usually due to a benign tumour of the pituitary gland. During the disease many complications occur, including cardiovascular disease and changes in the musculoskeletal, respiratory, and endocrine systems. Treatment includes surgery, medical therapy, and radiation. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.a2018.0080DOI Listing
January 2019
6 Reads

Glycosylation of thyroid-stimulating hormone receptor.

Endokrynol Pol 2019 ;70(1):86-100

Deptartment of Glycoconjugate Biochemistry, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland.

Thyroid-stimulating hormone receptor (TSHR) is a typical membrane receptor with 7-transmembrane helix domain (7TMR), coupled to the G protein. The mature receptor, present in the cell membrane, is composed of the A subunit comprising a large extracellular domain, and the B subunit, which consists of a short extracellular fragment anchored in the cell membrane and an intracellular part. The TSH receptor is subject to numerous post-translational modifications that determine its final structure and significantly affect its activity. Read More

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http://dx.doi.org/10.5603/EP.a2018.0077DOI Listing
January 2019
1 Read

Expression of CD9 and CD82 in Papillary Thyroid Microcarcinoma and Its Prognostic Significance.

Endokrynol Pol 2019 Feb 22. Epub 2019 Feb 22.

Soon Chun Hyang University Hospital Seoul, 59 Daesagwan-ro, 04401 Seoul, Korea, Republic Of.

Papillary thyroid microcarcinoma is a well-known malignant neoplasm with good prognosis. The known prognostic factors are patient's age, multifocality, and extrathyroidal extension. CD9 and CD82, members of the tetraspanin family, are expressed in numerous cancer cells and play many roles associated with cellular process. Read More

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http://dx.doi.org/10.5603/EP.a2019.0009DOI Listing
February 2019
1 Read

Acromegaly associated with GIST, non-small cell lung cancer, clear cell renal cancer, myeloma multiplex, medulla oblongata tumor, adrenal adenoma and follicular thyroid nodules.

Endokrynol Pol 2019 Feb 11. Epub 2019 Feb 11.

Dept. of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Pasteura 4, 50-367 Wrocłąw, Poland.

Background: Acromegaly is associated with increased growth hormone (GH) and insulin-like growth factor-I (IGF-I) secretion which may support tumor development and growth.

Case Presentation: A 68-year old woman was diagnosed with acromegaly due to typical clinical and hormonal characteristics. While a contrast-enhanced MRI at diagnosis did not reveal a pituitary adenoma, a 5 mm lesion was identified on repeat scanning 13 months later. Read More

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http://dx.doi.org/10.5603/EP.a2019.0005DOI Listing
February 2019
6 Reads

The efficacy of microperimetry and contrast sensitivity test in the diagnosis of optic chiasm compression due to pituitary adenomas.

Endokrynol Pol 2019 Jan 30. Epub 2019 Jan 30.

Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Introduction: The aim of the study was to determine which microperimetry and contrast sensitivity test parameters would prove the most valuable during diagnosing optic chiasm compression due to pituitary adenomas.

Methods: Control group comprised healthy individuals (Group 1). Patients with pituitary macroadenoma were divided into two groups: Group 2 - absent optic chiasm compression, Group 3 - present optic chiasm compression detected on contrast-enhanced Magnetic Resonance Imaging (MRI). Read More

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http://dx.doi.org/10.5603/EP.a2019.0003DOI Listing
January 2019
1 Read

Expression of α-Klotho protein in human thyroid cancers - an immunohistochemical study.

Endokrynol Pol 2019 Jan 30. Epub 2019 Jan 30.

Department of Neuroendocrinology, Interfaculty Chair of Laboratory and Molecular Medicine, Medical University of Lodz, Pomorska 251, 92-213 Łódź, Poland.

Background: The α-Klotho protein was discovered as a gene controlling the process of aging but the further studies indicated that it also plays a role of a tumour suppressor. Although the numerous studies were performed on the role of the α-Klotho gene and protein in neoplasia, the data on α-Klotho protein expression in thyroid cancers are very scarce. Our study presents the immunohistochemical investigation of α-Klotho expression in benign and malignant thyroid tumours. Read More

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http://dx.doi.org/10.5603/EP.a2019.0004DOI Listing
January 2019

Pernicious anemia and endocrine glands antibodies.

Endokrynol Pol 2019 Jan 16. Epub 2019 Jan 16.

Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

Introduction: The aim of the study was to determine the frequency of occurrence of antibodies participating in the development of endocrine diseases in patients with autoimmune hematopoietic disease, thus documenting the potential suitability of specific diagnostic and screening tests.

Material And Methods: The study group consisted of 124 persons (men and women) with newly diagnosed Pernicious Anemia (PA) and the control group (C) of 41 healthy people. Antibodies against: internal factor (IFAb), gastric parietal cells (APCA), thyroid peroxidase (TPOAb), thyroglobulin (TgAb), adrenal cortex (AdrenalAb) and pituitary anterior lobe (PituitaryAb) were determined in the blood. Read More

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http://dx.doi.org/10.5603/EP.a2018.0086DOI Listing
January 2019
3 Reads

Spatio-temporal image correlation (STIC) in evaluation of advanced neuroendocrine tumors.

Endokrynol Pol 2019 Jan 11. Epub 2019 Jan 11.

Klinika Endokrynologii i Nowotworów Neuroendokrynnych, Śląski Uniwersytet Medyczny w Katowicach, Ceglana 35, 40-514 Katowice, Poland.

Background: 4D Ultrasound technology merging Power Doppler option called High Definition Flow (HDF) with Spatio-Temporal Image Correlation (STIC) is used in gynecology and obstetrics. It seems to be a promising tool in assessing tissue vascularization.

Aim: To assess whether HDF STIC technique could be a useful tool for evaluation of gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) advancement. Read More

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http://dx.doi.org/10.5603/EP.a2019.0001DOI Listing
January 2019
1 Read

Novel inflammatory biomarkers may reflect subclinical inflammation in young healthy adults with obesity.

Endokrynol Pol 2019 Jan 11. Epub 2019 Jan 11.

2nd Department of Cardiology and Angiology, Silesian Center for Heart Diseases, Zabrze, Poland.

Introduction: Obesity is often accompanied by low-grade inflammation. In the last years a few blood-based inflammatory markers - neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and monocyte-to-high-density lipoprotein ratio (MHR) have been identified. They have been proven to correlate well with established inflammatory markers such as hsCRP, and have a prognostic value among others in patients with coronary artery disease, heart failure and malignancies. Read More

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http://dx.doi.org/10.5603/EP.a2019.0002DOI Listing
January 2019
6 Reads

V Congress of Polish Society of Neuroendocrinology 21-22 September, 2018 Kraków - Late abstracts.

Authors:
Late Abstracts

Endokrynol Pol 2018 ;69(6):742-745

V Congress of Polish Society of Neuroendocrinology 21-22 September, 2018 Kraków - Late abstracts. Read More

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April 2019
2 Reads

Klotho protein function among patients with type 1 diabetes.

Endokrynol Pol 2018 ;69(6):696-704

Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Raszeja Hospital, Poznan, Poland.

The fibroblast growth factor 23 (FGF23) and Klotho system play a very important role in the regulation of the human body metabolism. On the one hand, they promote longevity, and on the other hand they promote insulin resistance. Nowadays, accelerated aging in diabetes as the main consequence of chronic complications of the disease is postulated. Read More

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http://dx.doi.org/10.5603/EP.a2018.0070DOI Listing
April 2019
2 Reads

List do Czytelników/Letter to Readers.

Authors:
Beata Kos-Kudła

Endokrynol Pol 2018 ;69(6):642-644

Słowo wstępne do "Endokrynologia Polska" 69 (6) 2018. Read More

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April 2019
1 Read

The effects of cannabinoids on the endocrine system.

Endokrynol Pol 2018 ;69(6):705-719

Chair and Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poland.

Cannabinoids are the derivatives of the cannabis plant, the most potent bioactive component of which is tetrahydrocannabinol (THC). The most commonly used drugs containing cannabinoids are marijuana, hashish, and hashish oil. These compounds exert their effects via interaction with the cannabinoid receptors CB1 and CB2. Read More

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http://dx.doi.org/10.5603/EP.a2018.0072DOI Listing
April 2019
3 Reads

Endocrine complications of cancer immunotherapy.

Endokrynol Pol 2018 ;69(6):722-733

Department of Nuclear Medicine and Endocrine Oncology, Maria Skłodowska-Curie Institute - Oncology Centre, Gliwice Branch, Gliwice, Poland.

Immunotherapy using monoclonal antibodies - checkpoint inhibitors - is a dynamically evolving discipline of clinical oncology and a new hope for patients with advanced and disseminated cancer. However, the activation of T-lymphocytes can at the same time lead to autoimmune response and destruction of healthy organs, which is a serious adverse effect that can also affect the endocrine system. Here we present possible endocrine complications of immunotherapy with contemporary inhibitors of immune checkpoints (CTLA-4, PD-1, PD-L1/L2), their frequency, symptoms, and proposed grade-dependent treatment. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.a2018.0073DOI Listing
April 2019
9 Reads

The effects of Z56822977 on biosynthesis of serotonin in the brain of rats in the conditions of MSG-induced obesity.

Endokrynol Pol 2018 ;69(5):536-544

Bogomolets National Medical University, T. Shevchenko boulevard, 13, Kyiv, Ukraine.

Wstęp: Badanie przeprowadzono w celu wyjaśnienia wpływu Z56822977 na biosyntezę serotoniny w mózgu szczurów z otyłością wy-wołaną podawaniem glutaminianu sodu (monosodium glutamate, MSG). Materiał i metody: W badaniu wykorzystano 18 samców szczura. Zwierzęta podzielono na trzy grupy: 1 - grupa kontrolna, 2 - grupa MSG, 3 - grupa MSG + Z56822977. Read More

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http://dx.doi.org/10.5603/EP.2018.0058DOI Listing
April 2019
4 Reads

The influence of hypothyroidism and substitution treatment on thyroid hormone conversion ratios and rT3 concentration in patients with end-stage renal failure.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, ul. Banacha 1a, 02-097 Warsaw, Poland.

The increasing number of patients with end-stage renal disease (ESRD) requires seeking new opportunities to improve their quality of life not only because of kidney disease, but also due to other disturbances, such as thyroid hormone disorders. The aim of the study The objective of the study was to evaluate the influence of coexisting hypothyroidism and thyroid hormone therapy in patients with ESRD on thyroid hormone conversion ratios and rT3 concentration. Material and methods The study involved 85 patients aged 26 to 87 years, with a mean age of 59,62±15,45 years. Read More

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http://dx.doi.org/10.5603/EP.a2018.0087DOI Listing
November 2018
3 Reads

Subclinical hyperthyroidism in the course of autonomous nodules - clinical evaluation.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Katedra i Klinika Endokrynologii, Uniwersytet Medyczny w Lublinie, leje Racławickie 1, 20-059 Lublin, Poland.

Introduction Subclinical hyperthyroidism (SCH) also known as mildly symptomatic has recently been diagnosed more frequently. One of the main endogenous causes of this disorder is autonomously functioning thyroid nodule (AFTN). Despite the fact that it is usually asymptomatic SCH entails repercussions on the cardiovascular system and bone as well as carries a risk of progression to overt hyperthyroidism with a typical clinical picture. Read More

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http://dx.doi.org/10.5603/EP.a2018.0088DOI Listing
November 2018
19 Reads

Comparison of adipose tissue derived genes in endogenous Cushing's syndrome versus diet-induced obesity.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Division of Endocrinology, 2nd Department of Medicine, Hungarian Defense Forces - Military Hospital, Podmaniczky str. 111., 1062 Budapest, Hungary.

Introduction: Dysregulation of adipokine secretion and action are characteristic features of obesity that is a main clinical feature of Cushing's syndrome (CS). We have investigated whether endogenous glucocorticoid excess influences adipose tissue derived gene expression.

Material And Methods: mRNA expression of adipokines; adiponectin, resistin, tumor necrosis factor-, interleukin-6 (IL-6), angiotensinogen (AGT), plasminogen activator inhibitor type 1, retinol binding protein 4, visfatin, cystatin C was assessed by quantitative real-time RT-PCR in visceral adipose tissue removed during abdominal surgery of eight patients with CS, and six control patients. Read More

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http://dx.doi.org/10.5603/EP.a2018.0091DOI Listing
November 2018
5 Reads

Adropin in women with polycystic ovary syndrome.

Endokrynol Pol 2018 Dec 10. Epub 2018 Dec 10.

Wroclaw Medical University, Department of Endocrinology, Diabetes and Isothope Therapy, L. Pasteura 4, 50-367 Wroclaw, Poland.

Introduction: Women with polycystic ovary syndrome (PCOS) frequently develop metabolic complications. Among the new markers responsible for metabolic disorders, adropin seems to be of the great significance.

Material And Methods: 134 women aged 17-45 years were enrolled. Read More

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http://dx.doi.org/10.5603/EP.a2018.0092DOI Listing
December 2018
4 Reads

The association of thyroid-stimulating hormone (TSH) and free thyroxine (fT4) concentration levels with carbohydrate and lipid metabolism in obese and overweight teenagers.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Medical University of Gdansk, Department of Pediatrics, Diabetology and Endocrinology, ul Dębinki 7, 80-292 Gdańsk, Poland.

Introduction: Obesity has increased rapidly among children and adolescents during the last 30 years. Pediatric patients with a BMI >85th centile are more often diagnosed with increased TSH levels than children with proper body weight.

Materials And Methods: The data of 961 overweight and obese children, aged 13, recruited in four cities in Poland as part of PoZdro!, a two-year prophylactic program, were analysed to observe the relationship between serum TSH and fT4 concentration and carbohydrate and lipid metabolism parameters, as well as anthropometric parameters. Read More

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http://dx.doi.org/10.5603/EP.a2018.0090DOI Listing
November 2018
22 Reads

Thyroid scintigraphy in three-year-old children with congenital hypothyroidism in correlation with neonatal TSH.

Authors:
Majid Aminzadeh

Endokrynol Pol 2019 19;70(1):43-48. Epub 2018 Nov 19.

Pediatric Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Islamic Republic Of.

Introduction: A large number of congenital hypothyroidism (CH) cases in Iran are transient. This study was designed to investigate the aetiology of permanent CH (PCH) by thyroid scintigraphy (TS) and its relationship with the first diagnostic thyrotropin (TSH).

Material And Methods: During 12 years (2005-2017) of CH screening in southwest Iran, all infants referred with the diagnosis of CH were followed until their third birthday, when they were re-evaluated for serum T4, TSH after discontinuing the treatment for 3-4 weeks. Read More

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http://dx.doi.org/10.5603/EP.a2018.0083DOI Listing
November 2018
17 Reads

Resistance to thyroid hormone with a mutation of the thyroid β receptor gene in an eight-month-old infant - a case report.

Endokrynol Pol 2019 19;70(1):124-130. Epub 2018 Nov 19.

Department of Paediatrics and Paediatric Endocrinology, School of Medicine in Katowice, Katowice, Poland.

Introduction: Resistance to thyroid hormone (RTHβ) is a rare syndrome of impaired tissue responsiveness to thyroid hormones (THs). The disorder has an autosomal dominant or recessive pattern of inheritance. Most of the reported mutations have been detected in the thyroid hormone receptorβ gene (THRβ). Read More

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http://dx.doi.org/10.5603/EP.a2018.0082DOI Listing
November 2018
11 Reads

The role of adiponectin and leptin in the treatment of ovarian cancer patients.

Endokrynol Pol 2019 19;70(1):57-63. Epub 2018 Nov 19.

Department of Toxicology and Addiction, Public Health Faculty, Bytom, Poland.

Introduction: Ovarian cancer is most frequently detected in the advanced stage. Although its pathogenesis is not fully elucidated, it is assumed that body susceptibility and hormonal disorders are responsible. The role of some cytokines as predictors in the treatment process is still investigated. Read More

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http://dx.doi.org/10.5603/EP.a2018.0081DOI Listing
November 2018
12 Reads

Clinical case seminar: Familial intracranial germinoma.

Endokrynol Pol 2018 ;69(5):612-618

Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Belgrade, Serbia, Serbia and Montenegro; University of Belgrade, School of Medicine, Belgrade, Serbia.

Background: Intracranial germinomas (ICG) are uncommon brain neoplasms with extremely rare familial occurance. Since ICG invades hypothalamus and/or pituitary, the endocrine dysfunction is one of the common determinants of these tumors. We presented two brothers with the history of ICG. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.2018.0060DOI Listing
April 2019
23 Reads

Endocrine implications of obesity and bariatric surgery.

Endokrynol Pol 2018 ;69(5):574-597

Department of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Krakow, Poland.

Introduction: Obesity is a highly prevalent disease in the world associated with the disorders of endocrine system. Recently, it may be concluded that the only effective treatment of obesity remains bariatric surgery. The aim of the review was to compare the concepts of appetite hormonal regulation, reasons of obesity development and bariatric procedures published over the last decade. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.2018.0059DOI Listing
April 2019
5 Reads

Capecitabine plus temozolomide in well or moderately differentiated primary atypical neuroendocrine tumors: a single centre experience of two cases.

Endokrynol Pol 2018 Oct 25. Epub 2018 Oct 25.

San Luigi Gonzaga Hospital, Regione Gonzole 10, 10043 Turin, Italy.

Introduction: Neuroendocrine neoplasms (NENs) are a rare and heterogeneous group of tumors, with a variety of primary origins and variable aggressiveness. NENs with an atypical primary origin, such as breast and retroperitoneal NENs, are extremely rare. As a consequence, an established diagnostic and therapeutic strategy in this particular subgroup is lacking. Read More

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http://dx.doi.org/10.5603/EP.a2018.0076DOI Listing
October 2018
3 Reads

Endothelin-1 (ET-1), N-terminal fragment of pro-atrial natriuretic peptide (NTpro-ANP), and tumour necrosis factor alpha (TNF-α) in children with primary hypertension and hypertension of renal origin.

Endokrynol Pol 2019 25;70(1):37-42. Epub 2018 Oct 25.

Department of Paediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland.

Introduction: Hypertension is regarded as a condition of mild inflammation and endothelial imbalance. The aim of the study was to evaluate serum concentrations of biomarkers of inflammation and endothelial function: tumour necrosis factor alpha (TNF-α), endothelin-1 (ET-1), and N-terminal fragment of pro-atrial natriuretic peptide (NTpro-ANP) in hypertensive and normotensive children.

Material And Methods: We studied 63 children aged 13. Read More

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http://dx.doi.org/10.5603/EP.a2018.0079DOI Listing
October 2018
1 Read

Intracerebral hemorrhage as a first sign of pheochromocytoma: case report and review of the literature.

Endokrynol Pol 2018 Oct 23. Epub 2018 Oct 23.

Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center, Belgrade, Serbia; Medical Faculty, University of Belgrade, Belgrade, Serbia.

Pheochromocytomas and sympathetic paragangliomas are rare catecholamine-secreting tumors and represent very rare causes of intracerebral hemorrhage in young, with only few cases reported. A 32-year-old man presented to our emergency department because of sudden onset of severe headache. He had a six months history of paroxysmal headache, palpitations and sweating. Read More

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http://dx.doi.org/10.5603/EP.a2018.0075DOI Listing
October 2018
26 Reads

Treatment of severe primary IGF-1 deficiency using rhIGF-1 preparation - first three years of Polish experience.

Endokrynol Pol 2019 23;70(1):20-27. Epub 2018 Oct 23.

Department of Paediatrics, Endocrinology, Diabetology, Metabolic Disorders, and Cardiology of Developmental Age, Pomeranian Medical University, Szczecin, Poland.

Introduction: The objective of this study was to analyse the effects of the first three years of treatment with recombinant human insulinlike growth factor 1 (rhIGF-1) in patients from the Polish population.

Material And Methods: Twenty-seven children (22 boys and five girls) aged 2.8 to 16. Read More

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http://dx.doi.org/10.5603/EP.a2018.0074DOI Listing
October 2018
6 Reads

Sexual function and depressive symptoms in men with overt hyperthyroidism.

Endokrynol Pol 2019 11;70(1):64-71. Epub 2018 Oct 11.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Introduction: Although hyperthyroidism is characterised by female predominance, its presence may lead to the development of numerous complications in both sexes. This study was aimed at investigating sexual function and depressive symptoms in men with overt hyperthyroidism of autoimmune and non-autoimmune origin.

Material And Methods: The study population consisted of three age-matched groups: men with overt hyperthyroidism and Graves' disease (group A; n = 20), men with overt hyperthyroidism and toxic multinodular goitre or toxic adenoma (group B; n = 21), and men with normal thyroid function (group C; n = 23). Read More

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http://dx.doi.org/10.5603/EP.a2018.0069DOI Listing
October 2018
3 Reads

False-positive radioiodine whole-body scan due to a renal cyst.

Endokrynol Pol 2018 11;69(6):736-739. Epub 2018 Oct 11.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Patients affected by differentiated thyroid cancer are treated surgically and by ablative radioiodine therapy. A post-therapy whole-body scan allows detection of thyroid remnants or local and distant metastases, although false-positive findings may be observed. We report a case of a 75-year-old woman with follicular thyroid cancer, who underwent ablative radioiodine treatment. Read More

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http://dx.doi.org/10.5603/EP.a2018.0071DOI Listing
April 2019
6 Reads

The effect of short-term perindopril and telmisartan treatment on circulating levels of anti-inflammatory cytokines in hypertensive patients.

Endokrynol Pol 2018 27;69(6):667-674. Epub 2018 Sep 27.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Introduction: Both angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers were found to reduce plasma levels of proinflammatory cytokines. No previous study has compared their effect on the production of anti-inflammatory cytokines.

Material And Methods: The study enrolled 52 patients with grade 1 and grade 2 arterial hypertension. Read More

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http://dx.doi.org/10.5603/EP.a2018.0068DOI Listing
April 2019
2 Reads

The association between serum metalloproteinase concentration, obesity, and hormone levels in reproductive-aged women.

Endokrynol Pol 2019 27;70(1):49-56. Epub 2018 Sep 27.

1st Department of Obstetrics and Gynegology, Medical University of Warsaw, Warsaw, Poland.

Introduction: Increased levels and activity of some matrix metalloproteinases (MMPs) are described in obesity-related vascular diseases. Factors that influence MMP blood concentration are still being investigated. This research aims to evaluate the concentration of most types of MMPs: collagenases (MMP-1, -3, -8, -13), matrilysin (MMP-7), gelatinase (MMP-9), and metalloelastase (MMP-12) in serum of women in reproductive age in relation with their body mass index (BMI), age, oestradiol, and progesterone concentrations. Read More

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http://dx.doi.org/10.5603/EP.a2018.0067DOI Listing
September 2018
4 Reads

Oncocytic neoplasms; rare adrenocortical tumours - a report of eleven patients.

Endokrynol Pol 2018 27;69(6):682-687. Epub 2018 Sep 27.

Department of Internal Medicine, Division of Endocrinology and Metabolism, Kastamonu State Hospital, Kastamonu, Turkey.

Introduction: Oncocytomas of adrenal glands are extremely rare and usually present as incidentally detected masses. We aimed to present a series of patients with adrenal oncocytomas and review the literature.

Material And Methods: Electronic database of patients with adrenal tumours, who were admitted to the internal medicine and endocrinology and metabolism outpatient clinics of Uludag University Medical Faculty between January 2005 and November 2016, were assessed retrospectively. Read More

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http://dx.doi.org/10.5603/EP.a2018.0066DOI Listing
April 2019
3 Reads

Vitamin D status including 3-epi-25(OH)D3 among adult patients with thyroid disorders during summer months.

Endokrynol Pol 2018 27;69(6):653-660. Epub 2018 Sep 27.

Department of Endocrinology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland.

Introduction: In the context of pleiotropic vitamin D effects, its role has also been investigated in thyroid pathology, in particular autoimmune thyroid diseases (AITD). However, available data concerning vitamin D status in Polish patients with thyroid disorders are inconclusive. In the study we investigated vitamin D status and adequacy of supplementation, as well as sunlight exposure during summer months among adult patients with thyroid diseases. Read More

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http://dx.doi.org/10.5603/EP.a2018.0065DOI Listing
April 2019
4 Reads

The importance of combined NGS and MLPA genetic tests for differential diagnosis of maturity onset diabetes of the young.

Endokrynol Pol 2019 27;70(1):28-36. Epub 2018 Sep 27.

Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia and Montenegro.

Introduction: Maturity onset diabetes of the young (MODY) is a rare form of monogenic diabetes. Being clinically and genetically heterogeneous, it is often misdiagnosed as type 1 or type 2 diabetes, leading to inappropriate therapy. MODY is caused by a single gene mutation. Read More

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http://dx.doi.org/10.5603/EP.a2018.0064DOI Listing
September 2018
13 Reads

Detection of new potentially pathogenic mutations in two patients with primary pigmented nodular adrenocortical disease (PPNAD) - case reports with literature review.

Endokrynol Pol 2018 27;69(6):675-681. Epub 2018 Sep 27.

Department of Endocrinology and Diabetology, The Children's Memorial Health Institute, Warsaw, Poland.

Introduction: Primary pigmented nodular adrenocortical disease (PPNAD) is a rare form of ACTH-independent Cushing's syndrome (CS). Half of patients with PPNAD are sporadic cases and the other half familial.

Material And Methods: We present two patients with PPNAD confirmed by genetic analysis. Read More

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http://dx.doi.org/10.5603/EP.a2018.0063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347113PMC
April 2019
8 Reads

The effect of atorvastatin on sexual function and depressive symptoms in young women with elevated cholesterol levels - a pilot study.

Endokrynol Pol 2018 27;69(6):688-694. Epub 2018 Sep 27.

Chair of Woman's Health, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.

Introduction: Statins were found to improve erectile function in men. No previous study has prospectively investigated sexual functioning in women receiving these agents. The aim of this study was to evaluate the impact of atorvastatin therapy on female sexual function, and depressive symptoms in young women with elevated cholesterol levels. Read More

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http://dx.doi.org/10.5603/EP.a2018.0062DOI Listing
April 2019
8 Reads

Determinants of obesity in population of PURE study from Lower Silesia.

Endokrynol Pol 2018 19;69(6):644-652. Epub 2018 Sep 19.

Department of Endocrinology, Diabetes and Isothope Therapy, Wroclaw Medical University, Wroclaw, Poland.

Introduction: The knowledge about obesity pathogenesis is insufficient. The aim of our study was to investigate environmental and individual determinants of obesity in population of PURE study from Lower Silesia.

Material And Methods: This was a cross sectional observation of 1064 inhabitants of Wroclaw and neighbouring rural area (671 women, 393 men), who took part in PURE study in years 2007-2010. Read More

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http://dx.doi.org/10.5603/EP.a2018.0061DOI Listing
April 2019
8 Reads

Serum progranulin levels are elevated in infertile women with obesity.

Endokrynol Pol 2018 19;69(6):661-666. Epub 2018 Sep 19.

Konya Education and Research Hospital, Konya, Turkey.

Introduction: The aim of the present study was to investigate the changes in serum progranulin and sex hormone levels in infertile women with obesity.

Material And Methods: A total of 171 infertile women who had fertility desire were included in this cross-sectional study. The initial assessment included measurements of weight, height, waist circumference, and hip circumference to calculate body mass index (BMI) and waist/hip ratio. Read More

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http://dx.doi.org/10.5603/EP.a2018.0044DOI Listing
April 2019
3 Reads