2,888 results match your criteria Endokrynologia Polska[Journal]


The influence of hypothyroidism and substitution treatment on thyroid hormone conversion ratios and rT3 concentration in patients with end-stage renal failure.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, ul. Banacha 1a, 02-097 Warsaw, Poland.

The increasing number of patients with end-stage renal disease (ESRD) requires seeking new opportunities to improve their quality of life not only because of kidney disease, but also due to other disturbances, such as thyroid hormone disorders. The aim of the study The objective of the study was to evaluate the influence of coexisting hypothyroidism and thyroid hormone therapy in patients with ESRD on thyroid hormone conversion ratios and rT3 concentration. Material and methods The study involved 85 patients aged 26 to 87 years, with a mean age of 59,62±15,45 years. Read More

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http://dx.doi.org/10.5603/EP.a2018.0087DOI Listing
November 2018
2 Reads

Subclinical hyperthyroidism in the course of autonomous nodules - clinical evaluation.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Katedra i Klinika Endokrynologii, Uniwersytet Medyczny w Lublinie, leje Racławickie 1, 20-059 Lublin, Poland.

Introduction Subclinical hyperthyroidism (SCH) also known as mildly symptomatic has recently been diagnosed more frequently. One of the main endogenous causes of this disorder is autonomously functioning thyroid nodule (AFTN). Despite the fact that it is usually asymptomatic SCH entails repercussions on the cardiovascular system and bone as well as carries a risk of progression to overt hyperthyroidism with a typical clinical picture. Read More

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http://dx.doi.org/10.5603/EP.a2018.0088DOI Listing
November 2018
4 Reads

Comparison of adipose tissue derived genes in endogenous Cushing's syndrome versus diet-induced obesity.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Division of Endocrinology, 2nd Department of Medicine, Hungarian Defense Forces - Military Hospital, Podmaniczky str. 111., 1062 Budapest, Hungary.

Introduction: Dysregulation of adipokine secretion and action are characteristic features of obesity that is a main clinical feature of Cushing's syndrome (CS). We have investigated whether endogenous glucocorticoid excess influences adipose tissue derived gene expression.

Material And Methods: mRNA expression of adipokines; adiponectin, resistin, tumor necrosis factor-, interleukin-6 (IL-6), angiotensinogen (AGT), plasminogen activator inhibitor type 1, retinol binding protein 4, visfatin, cystatin C was assessed by quantitative real-time RT-PCR in visceral adipose tissue removed during abdominal surgery of eight patients with CS, and six control patients. Read More

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http://dx.doi.org/10.5603/EP.a2018.0091DOI Listing
November 2018
1 Read

Adropin in women with polycystic ovary syndrome.

Endokrynol Pol 2018 Dec 10. Epub 2018 Dec 10.

Wroclaw Medical University, Department of Endocrinology, Diabetes and Isothope Therapy, L. Pasteura 4, 50-367 Wroclaw, Poland.

Introduction: Women with polycystic ovary syndrome (PCOS) frequently develop metabolic complications. Among the new markers responsible for metabolic disorders, adropin seems to be of the great significance.

Material And Methods: 134 women aged 17-45 years were enrolled. Read More

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http://dx.doi.org/10.5603/EP.a2018.0092DOI Listing
December 2018
1 Read

The association of thyroid-stimulating hormone (TSH) and free thyroxine (fT4) concentration levels with carbohydrate and lipid metabolism in obese and overweight teenagers.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Medical University of Gdansk, Department of Pediatrics, Diabetology and Endocrinology, ul Dębinki 7, 80-292 Gdańsk, Poland.

Introduction: Obesity has increased rapidly among children and adolescents during the last 30 years. Pediatric patients with a BMI >85th centile are more often diagnosed with increased TSH levels than children with proper body weight.

Materials And Methods: The data of 961 overweight and obese children, aged 13, recruited in four cities in Poland as part of PoZdro!, a two-year prophylactic program, were analysed to observe the relationship between serum TSH and fT4 concentration and carbohydrate and lipid metabolism parameters, as well as anthropometric parameters. Read More

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http://dx.doi.org/10.5603/EP.a2018.0090DOI Listing
November 2018
4 Reads

[Tc]-99m thyroid scintigraphy in more than 210 cases of permanent congenital hypothyroidism and its correlation with the 1st diagnostic serum thyrotropin.

Authors:
Majid Aminzadeh

Endokrynol Pol 2018 Nov 19. Epub 2018 Nov 19.

Objective: A big part of cases of congenital hypothyroidism(CH) in Iran are transient. This study designed to investigate etiology of permanent CH(PCH) by thyroid scintigraphy(TS) and its relationship with the first diagnostic thyrotropin(TSH).

Methods: During twelve years (2005-2017) of CH screening in southwest Iran, all infants referred with the diagnosis of CH were followed until the 3rd birthday that they were reevaluated for serum T4,TSH after 3-4 weeks treatment discontinuation. Read More

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http://dx.doi.org/10.5603/EP.a2018.0083DOI Listing
November 2018
7 Reads

RESISTANCE TO THYROID HORMONE WITH A MUTATION OF THE THYROID β RECEPTOR GENE IN AN EIGHT-MONTH OLD INFANT: CASE REPORT.

Endokrynol Pol 2018 Nov 19. Epub 2018 Nov 19.

Katedra i Klinika Pediatrii i Endokrynologii Dziecięcej Śląskiego Uniwersytetu Medycznego w Katowicach, ul. Medyków 16, 40-752 Katowice, Poland.

Introduction: Resistance to thyroid hormone (RTHβ) is a rare syndrome of impaired tissue responsiveness to thyroid hormones (THs). The disorder has autosomal dominant or recessive pattern of inheritance. Most of reported mutations have been detected in the thyroid hormone receptor β gene (THRB). Read More

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http://dx.doi.org/10.5603/EP.a2018.0082DOI Listing
November 2018
3 Reads

The role of adiponectin and leptin in the treatment of ovarian cancer patients.

Endokrynol Pol 2018 Nov 19. Epub 2018 Nov 19.

Oncological Ward, Independent Public Health Care Unit, Voivodeship Specialized Hospital No 3, Energetyków 46 Str., 44-200 Rybnik, Poland.

Introduction: Ovarian cancer is most frequently detected in the advanced stage. Although its pathogenesis is not fully elucidated, it is assumed that body susceptibility and hormonal disorders are responsible. The role of some cytokines as predictors in the treatment process is still investigated. Read More

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http://dx.doi.org/10.5603/EP.a2018.0081DOI Listing
November 2018
4 Reads

Clinical case seminar: Familial intracranial germinoma.

Endokrynol Pol 2018 ;69(5):612-618

Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Belgrade, Serbia, Serbia and Montenegro; University of Belgrade, School of Medicine, Belgrade, Serbia.

Background: Intracranial germinomas (ICG) are uncommon brain neoplasms with extremely rare familial occurance. Since ICG invades hypothalamus and/or pituitary, the endocrine dysfunction is one of the common determinants of these tumors. We presented two brothers with the history of ICG. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.2018.0060DOI Listing
January 2018
8 Reads

Endocrine implications of obesity and bariatric surgery.

Endokrynol Pol 2018 ;69(5):574-597

Department of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Krakow, Poland.

Introduction: Obesity is a highly prevalent disease in the world associated with the disorders of endocrine system. Recently, it may be concluded that the only effective treatment of obesity remains bariatric surgery. The aim of the review was to compare the concepts of appetite hormonal regulation, reasons of obesity development and bariatric procedures published over the last decade. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.2018.0059DOI Listing
January 2018
3 Reads

Capecitabine plus temozolomide in well or moderately differentiated primary atypical neuroendocrine tumors: a single centre experience of two cases.

Endokrynol Pol 2018 Oct 25. Epub 2018 Oct 25.

San Luigi Gonzaga Hospital, Regione Gonzole 10, 10043 Turin, Italy.

Introduction: Neuroendocrine neoplasms (NENs) are a rare and heterogeneous group of tumors, with a variety of primary origins and variable aggressiveness. NENs with an atypical primary origin, such as breast and retroperitoneal NENs, are extremely rare. As a consequence, an established diagnostic and therapeutic strategy in this particular subgroup is lacking. Read More

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http://dx.doi.org/10.5603/EP.a2018.0076DOI Listing
October 2018

Endothelin-1 (ET-1), N-terminal fragment of proatrial natriuretic peptide (NTpro-ANP) and tumor necrosis factor alpha (TNF-α) in children with primary hypertension and hypertension of renal origin.

Endokrynol Pol 2018 Oct 25. Epub 2018 Oct 25.

Department of Paediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13-15, 41-800 Zabrze, Poland.

Introduction Hypertension is regarded to be a condition of mild inflammation and endothelial imbalance. The aim of the study was to evaluate serum concentrations of biomarkers of inflammation and endothelial function: tumor necrosis factor alpha (TNF-α), endothelin-1 (ET-1) and N-terminal fragment of proatrial natriuretic peptide (NTpro-ANP) in hypertensive and normotensive children. Material and methods We studied 63 children aged 13,56 ± 3,73 years, divided into: group with primary hypertension (n=50) and group with renal hypertension (n=13). Read More

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http://dx.doi.org/10.5603/EP.a2018.0079DOI Listing
October 2018

Intracerebral hemorrhage as a first sign of pheochromocytoma: case report and review of the literature.

Endokrynol Pol 2018 Oct 23. Epub 2018 Oct 23.

Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center, Belgrade, Serbia; Medical Faculty, University of Belgrade, Belgrade, Serbia.

Pheochromocytomas and sympathetic paragangliomas are rare catecholamine-secreting tumors and represent very rare causes of intracerebral hemorrhage in young, with only few cases reported. A 32-year-old man presented to our emergency department because of sudden onset of severe headache. He had a six months history of paroxysmal headache, palpitations and sweating. Read More

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http://dx.doi.org/10.5603/EP.a2018.0075DOI Listing
October 2018
8 Reads

Treatment of severe primary IGF-1 deficiency using rhIGF-1 preparation - first three years of Polish experience.

Endokrynol Pol 2018 Oct 23. Epub 2018 Oct 23.

Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland, Poland.

Introduction: The objective of this study was to analyze the effects of the first three years of treatment with recombinant human insulin-like growth factor 1 (rhIGF-1) in patients from the Polish population.

Material And Methods: Twenty-seven children (22 boys and 5 girls) aged 2.8 to 16. Read More

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http://dx.doi.org/10.5603/EP.a2018.0074DOI Listing
October 2018
1 Read

Sexual function and depressive symptoms in men with overt hyperthyroidism.

Endokrynol Pol 2018 Oct 11. Epub 2018 Oct 11.

Introduction: Although hyperthyroidism is characterized by female predominance, its presence may lead to the development of numerous complications in both sexes. This study was aimed at investigating sexual function and depressive symptoms in men with overt hyperthyroidism of autoimmune and non-autoimmune origin.

Material And Methods: The study population consisted of three age-matched groups: men with overt hyperthyroidism and Graves' disease (group A; n=20), men with overt hyperthyroidism and toxic multinodular goiter or toxic adenoma (group B; n=21) and men with normal thyroid function (group C; n=23). Read More

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http://dx.doi.org/10.5603/EP.a2018.0069DOI Listing
October 2018
2 Reads

False-positive radioiodine whole body scan due to a renal cyst.

Endokrynol Pol 2018 Oct 11. Epub 2018 Oct 11.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences.

Patients affected by differentiated thyroid cancer are treated surgically and by ablative radioiodine therapy. Post-therapy whole body scan allows detecting thyroid remnants or local and distant metastases, although false-positive findings may be observed. We report a case of 75-year-old woman with follicular thyroid cancer, who underwent ablative radioiodine treatment. Read More

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http://dx.doi.org/10.5603/EP.a2018.0071DOI Listing
October 2018
3 Reads

The effect of short-term perindopril and telmisartan treatment on circulating levels of anti-inflammatory cytokines in hypertensive patients.

Endokrynol Pol 2018 Sep 27. Epub 2018 Sep 27.

Introduction: Both angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers were found to reduce plasma levels of proinflammatory cytokines. No previous study has compared their effect on production of anti-inflammatory cytokines.

Material And Methods: The study enrolled 52 patients with grade 1 and grade 2 arterial hypertension. Read More

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http://dx.doi.org/10.5603/EP.a2018.0068DOI Listing
September 2018

Serum metalloproteinase concentration might be a new predictor of cardiovascular risk in obese women.

Endokrynol Pol 2018 Sep 27. Epub 2018 Sep 27.

1st Department of Obstetrics and Gynegology, 1st Faculty of Medicine, Medical University of Warsaw, Starynkiewicza Sq. 1/3, 02-015 Warsaw, Poland.

Objective: Increased levels and activity of some MMPs are described in obesity-related vascular diseases. Factors that influence MMPs blood concentration are still investigated. This research aim to evaluate the concentration of most types of MMPs: collagenases (MMP-1,-3,-8,-13), matrilisine (MMP-7), gelatinase (MMP-9) and malloelsastase (MMP-12) in serum of women in reproductive age in relation with their body mass index (BMI), age, estradiol and progesterone concentrations. Read More

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http://dx.doi.org/10.5603/EP.a2018.0067DOI Listing
September 2018

ONCOCYTIC NEOPLASMS; RARE ADRENOCORTICAL TUMORS: A REPORT OF ELEVEN PATIENTS.

Endokrynol Pol 2018 Sep 27. Epub 2018 Sep 27.

Department of Internal Medicine, Division of Endocrinology and Metabolism, Kastamonu State Hospital, Kastamonu, Turkey.

Introduction: Oncocytomas arising in adrenal glands are extremely rare and usually detected incidentally. Herein, we aimed to present clinical, radiological, pathological and immunohistochemical staining aspects of 11 patients diagnosed as adrenal oncocytomas and review the literature.

Material And Methods: Patients' age, gender, symptoms suggesting hormonal activity, other illnesses, biochemical and endocrinological assessment, mass characteristics, pathological diagnosis and their follow-up periods from the date of surgery were recorded from their files who applied to internal medicine and endocrinology and metabolism outpatient clinics of Uludağ University Medical Faculty between January 2005 and November 2016. Read More

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http://dx.doi.org/10.5603/EP.a2018.0066DOI Listing
September 2018
1 Read

Vitamin D status including 3-epi-25(OH)D3 among adult patients with thyroid disorders during summer months.

Endokrynol Pol 2018 Sep 27. Epub 2018 Sep 27.

Department of Endocrinology and Internal Medicine, Medical University of Gdańsk, 7 Dębinki Street, 80-952 Gdańsk, Poland.

Introduction: In the context of pleiotropic vitamin D effects its role has also been investigated in thyroid pathology, in particular autoimmune thyroid diseases (AITD). However, available data concerning vitamin D status among Polish adult population are inconclusive.

Aim: In the study we investigated vitamin D status and adequacy of supplementation, as well as sunlight exposure during summer months among adult patients with thyroid diseases. Read More

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http://dx.doi.org/10.5603/EP.a2018.0065DOI Listing
September 2018
3 Reads

The importance of combined NGS and MLPA genetic tests for differential diagnosis of Maturity onset diabetes of the young.

Endokrynol Pol 2018 Sep 27. Epub 2018 Sep 27.

Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 444a, 11010 Belgrade, Serbia and Montenegro.

Introduction: Maturity onset diabetes of the young (MODY) is a rare form of monogenic diabetes. Being clinically and genetically heterogeneous, it is often misdiagnosed as type 1 or type 2 diabetes, leading to inappropriate therapy. MODY is caused by a single gene mutation. Read More

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http://dx.doi.org/10.5603/EP.a2018.0064DOI Listing
September 2018
7 Reads

Detection of new potentially pathogenic mutations in 2 patients with primary pigmented nodular adrenocortical disease (PPNAD) - case reports with literature review.

Endokrynol Pol 2018 Sep 27. Epub 2018 Sep 27.

Department of Endocrinology and Diabetology, the Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.

Introduction: Primary pigmented nodular adrenocortical disease (PPNAD) is a rare form of ACTH-independent Cushing's syndrome (CS). Half of patients with PPNAD are sporadic cases and the other half familial.

Material And Methods: We present 2 patients with PPNAD confirmed by genetic analysis. Read More

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http://dx.doi.org/10.5603/EP.a2018.0063DOI Listing
September 2018
1 Read

The effect of atorvastatin on sexual function and depressive symptoms in young women with elevated cholesterol levels: a pilot study.

Endokrynol Pol 2018 Sep 27. Epub 2018 Sep 27.

Medical University of Silesia, Medykow 12, 40-750 Katowice, Poland.

Introduction: Statins were found to improve erectile function in men. No previous study has investigated prospectively sexual functioning in women receiving these agents.

Aim: The aim of this study was to evaluate the impact of atorvastatin therapy on female sexual functions and depressive symptoms in young women with elevated cholesterol levels. Read More

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http://dx.doi.org/10.5603/EP.a2018.0062DOI Listing
September 2018
6 Reads

Determinants of obesity in population of PURE study from Lower Silesia.

Endokrynol Pol 2018 Sep 19. Epub 2018 Sep 19.

Wroclaw Medical University, Department of Endocrinology, Diabetes and Isothope Therapy, L. Pasteura 4, 50-367 Wroclaw, Poland.

Background: The knowledge about obesity pathogenesis is insufficient. The aim of our study was to investigate environmental and individual determinants of obesity in population of PURE study from Lower Silesia.

Materials And Methods: This was a cross sectional observation of 1064 inhabitants of Wroclaw and neighbouring rural area (671 women, 393 men), who took part in PURE study in years 2007-2010. Read More

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http://dx.doi.org/10.5603/EP.a2018.0061DOI Listing
September 2018
3 Reads

Serum progranulin levels are elevated in infertile women with obesity.

Endokrynol Pol 2018 Sep 19. Epub 2018 Sep 19.

Konya Education and Research Hospital, Meram Yeni Yol, 042090 Konya, Turkey.

Objective: The aim of the present study was to investigate the changes in serum progranulin and sex hormone levels in infertile women with obesity.

Materials And Method: A total of 171 infertile women who have fertility desire were included in this cross-sectional study. The initial assessment included the measurements of weight, height, waist circumference and hip circumference to calculate body mass index (BMI), and waist/hip ratio. Read More

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http://dx.doi.org/10.5603/EP.a2018.0044DOI Listing
September 2018
1 Read

Pharmacotherapy of obesity - state of the art.

Endokrynol Pol 2018 ;69(4)

Medical University of Lublin.

Obesity, which affects about 13% of the world population, results in significant deterioration of health and serious clinical, mainly meta-bolic and cardiovascular complications. Although the basis of therapeutic treatment is behavioural treatment, often non-pharmacological effects do not produce the desired effect. Currently there are several drugs with a safe action profile that improve the effect of treatment (5-10% weight reduction). Read More

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http://dx.doi.org/10.5603/EP.2018.0048DOI Listing
January 2018
1 Read

A review of cardiovascular outcome trials in type 2 diabetes.

Endokrynol Pol 2018 ;69(4)

Type 2 diabetes is a complex metabolic disorder associated with a high risk of cardiovascular complications. In December 2008, due to concerns about the cardiac safety of antihyperglycaemic therapies, the Food and Drug Administration (FDA) published a new guidance on special requirements for the demonstration of cardiovascular safety for these medications. In 2012, similar recommendations were made for antidiabetic drug manufacturers by the European Medicines Agency (EMA). Read More

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http://dx.doi.org/10.5603/EP.2018.0053DOI Listing
January 2018
7 Reads

Management of Prader-Willi Syndrome (PWS) in adults - what an endocrinologist needs to know. Recommendations of the Polish Society of Endocrinology and the Polish Society of Paediatric Endocrinology and Diabetology.

Endokrynol Pol 2018 ;69(4)

Prader-Willi syndrome (PWS) is a complex genetic disorder characterised by a set of phenotypic traits, which include infantile hypotonia, short stature, and morbid obesity. Over the last 12 years, visible progress has been made in medical care management of PWS patients in Poland. Increasing awareness of the disorder in neonatal and paediatric care has led to early identification of the condition in neonates, followed by the institution of an appropriate dietary regime, introduction of physiotherapy, and early-onset recombinant human growth hormone (rhGH) treatment. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.2018.0047DOI Listing
January 2018
7 Reads

The polycystic ovary syndrome: a position statement from the Polish Society of Endocrinology, the Polish Society of Gynaecologists and Obstetricians, and the Polish Society of Gynaecological Endocrinology.

Endokrynol Pol 2018 ;69(4)

Katedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami Uniwersytetu Medycznego im. Piastów Śląskich we Wrocławiu.

Polycystic ovary syndrome (PCOS) diagnosis and therapy still arouse a lot of controversy. Each year brings new information, so, having collected the experience of three scientific societies, we present contemporary recommendations concerning PCOS diagnostics and treat-ment. In adult female diagnosis, we still use the Rotterdam criteria, which is two out of three of the follwing characteristics: a) ovulation abnormality, b) clinical or biochemical hyperandrogenism, and c) polycystic ovaries. Read More

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http://dx.doi.org/10.5603/EP.2018.0046DOI Listing
January 2018
1 Read

LanroNET - A Non-Interventional Prospective Study to Assess the Resource Utilization and Cost of Lanreotide Autogel 120 mg in Population of Polish Patients with Symptomatic Neuroendocrine Tumors.

Endokrynol Pol 2018 Aug 22. Epub 2018 Aug 22.

Ipsen Poland, 29th Jana Pawła II St., 00-867 Warsaw, Poland.

Introduction: The primary objective of the LanroNET study was to evaluate resource utilization and cost of symptomatic treatment of patients with neuroendocrine tumors (NET) using lanreotide autogel 120 mg.

Material And Methods: LanroNET was a multicentre, non-interventional, prospective study conducted at 12 clinical centers in Poland. Eligible patients were adults with symptomatic NET treated with lanreotide autogel 120 mg at least 3 months before enrolment. Read More

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http://dx.doi.org/10.5603/EP.a2018.0057DOI Listing

ALTERATIONS IN THYROID HORMONES IN BRAIN DEAD PATIENTS ARE RELATED TO NON-THYROIDAL ILLNESS SYNDROME.

Endokrynol Pol 2018 Aug 22. Epub 2018 Aug 22.

Duzce Uniiversity, Shool of Medicine, Deparment of Internal Medicine, Section of Intensive Car, Konuralp Yerleşkesi, Beciyörükler Mevkii,, 81620 Duzce, Turkey.

Introduction: Alterations in thyroid hormone levels occur in patients with acute neurologic disease states. The aim of this study is to study changes in thyroid hormones in patients with brain death (BD).

Material And Methods: Eleven brain-dead patients were studied prospectively. Read More

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http://dx.doi.org/10.5603/EP.a2018.0056DOI Listing
August 2018
5 Reads

Plasma adiponectin array in women with Alzheimer's disease.

Endokrynol Pol 2018 Aug 17. Epub 2018 Aug 17.

Department of Neuroendocrinology, Centre of Postgraduate Medical Education, Marymoncka 99/103, 01-813 Warsaw, Poland.

Introduction Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. Typical features of AD include memory loss, social dysfunction and physical impairment. Although the pathological findings in the central nervous system are well established, the etiological factors are poorly known. Read More

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http://dx.doi.org/10.5603/EP.a2018.0055DOI Listing
August 2018
13 Reads

National Program of Severe Growth Hormone Deficiency Treatment in Adults and Adolescents after Completion of Growth Promoting Therapy.

Endokrynol Pol 2018 Aug 17. Epub 2018 Aug 17.

Growth hormone (GH) has been used in the treatment of short stature in children with GH deficiency (GHD) for 60 years, and for about 30 years also in the treatment of adults with GHD, in whom such treatment is carried out due to metabolic indications. In Poland, GH treatment is reimbursed only in children with GHD, while so far it has not been refunded in adults with GHD. There are two groups of adults (or adolescents after growth completion) with GHD, who require GH therapy: patients with GHD that occurred in childhood (childhood-onset GHD - CO-GHD) and patients with GHD acquired in adulthood (adulthood-onset GHD - AO-GHD). Read More

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http://dx.doi.org/10.5603/EP.a2018.0054DOI Listing
August 2018
2 Reads

Chromogranin A and its role in the pathogenesis of diabetes mellitus.

Endokrynol Pol 2018 Aug 3. Epub 2018 Aug 3.

Semmelweis University, 2nd Department of Internal Medicine, Szentkiralyi u. 46., H-1088 Budapest, Hungary.

Chromogranin A is a member of the granin glycoprotein family that is expressed by the endocrine and neuroendocrine cells of different organs. Intracellularly, Chromogranin A contributes to the regulation of secretion, and gives several cleavage products after secretion. Some of its cleavage products modify the hormone functions in autocrine and paracrine ways, while the functions of others have not been fully understood yet. Read More

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http://dx.doi.org/10.5603/EP.a2018.0052DOI Listing
August 2018
12 Reads

The role of the cAMP/PKA signaling pathway in the inhibitory influence of melatonin on oxytocin and vasopressin secretion from the rat hypothalamo-neurohypophysial system.

Endokrynol Pol 2018 Aug 3. Epub 2018 Aug 3.

Department of Pathophysiology and Experimental Neuroendocrinology, Medical University of Lodz, ul. Narutowicza 60, 90-136 Lodz, Poland.

Introduction: Melatonin was found to inhibit forskolin-stimulated oxytocin (OT) and vasopressin (VP) release in vitro. The purpose of the present investigation was to evaluate the contribution of the cyclic 3',5'-adenosine monophosphate/protein kinase A (cAMP/PKA) signaling pathway in melatonin-dependent inhibition of OT and VP secretion from the rat hypothalamo-neurohypophysial (H-NH) system in vitro.

Material And Methods: The H-NH explants were placed in 1 ml of normal Krebs-Ringer (nK-R) buffer and first preincubated for 30 min in control buffer or in the presence of PKA inhibitor, i. Read More

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http://dx.doi.org/10.5603/EP.a2018.0051DOI Listing
August 2018
1 Read

The relation of pituitary adenomas invasiveness and the proliferative index measured by immunoexpression of topoisomerase IIα.

Endokrynol Pol 2018 Aug 3. Epub 2018 Aug 3.

Chair and Department of Endocrinology, Jagiellonian University Medical College, Kopernika 17, 31-501 Kraków, Poland.

Introduction: Cavernous sinus invasion by pituitary adenoma affects surgical procedure radicality, and consequently the postoperative course and prognosis in pituitary adenomas treatment. The search for pituitary adenoma aggressive behaviour markers is still a matter of debate.

Material And Methods: This study evaluates the relation of pituitary adenoma invasiveness to the expression of topoisomerase IIα in 72 patients who underwent transsphenoidal pituitary surgery. Read More

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http://dx.doi.org/10.5603/EP.a2018.0050DOI Listing
August 2018
2 Reads

Blood serum concentrations of gonadotropins and α-subunit in patients with gonadotropinomas in relation to the immunoreactivity of pituitary adenoma.

Endokrynol Pol 2018 Aug 3. Epub 2018 Aug 3.

Department of Immunoendocrinology. Chair of Endocrinology, Medical University of Lodz, Sterling Str. 1/3, 91-425 Lodż, Poland.

Introduction: Although the active gonadotropin-secreting pituitary adenomas are considered as very rare, the vast majority of pituitary tumours diagnosed as "nonfunctioning" express gonadotropins or their free β or α subunits. However, the systemic investigations comparing the serum concentrations of follitropin (FSH), lutropin (LH) and α-subunit (αSU) before surgery with the immunoreactivity of the respective substances in the excised tumours are still lacking.

Materials And Methods: Immunostaining of FSH, LH and αSU was compared in 43 surgically removed gonadotropin - expressing pituitary adenomas with serum concentrations of the above mentioned substances before surgery in the same patients. Read More

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http://dx.doi.org/10.5603/EP.a2018.0049DOI Listing
August 2018
2 Reads

Foetal goitrous hypothyroidism - easy to recognise, difficult to treat. Is combined intra-amniotic and intravenous L-thyroxine therapy an option?

Endokrynol Pol 2018 29;69(4). Epub 2018 Jun 29.

2nd Department of Obstetrics and Gynaecology, Centre of Medical Postgraduate Education, Warsaw, Department of Endocrinology, Centre of Medical Postgraduate Education, Warsaw.

Introduction: Foetal hypothyroidism negatively impacts somatic and neurological child development and can be the cause of serious obstetric and perinatal complications. We present a rare case of a large foetal dyshormonogenetic goitre, causing foetal neck hyperexten-sion, oesophageal compression, and cardiac high-output failure.

Material And Methods: A foetal goitre complicated by cardiomegaly and polyhydramnios was diagnosed at 23 weeks of gestation (WG) on a routine ultrasonographic (US) assessment in a healthy nullipara. Read More

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http://dx.doi.org/10.5603/EP.a2018.0045DOI Listing
June 2018
3 Reads

Cystic lesions of the sellar-suprasellar region - diagnosis and treatment.

Endokrynol Pol 2018 ;69(2):212-228

Klinika Endokrynologii, Chorób Metabolicznych i Chorób Wewnętrznych, Pomorski Uniwersytet Medyczny, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.

The differentiation of cystic lesions located in the sellar-suprasellar region is a significant problem in clinical practice because of the similarities in their clinical, radiological, and even histopathological picture. Arriving at the right diagnosis is vital for taking appropriate therapeutic decisions. The most frequent clinical manifestation of lesions located in the sellar-suprasellar region is headache. Read More

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http://dx.doi.org/10.5603/EP.2018.0023DOI Listing
October 2018
20 Reads

Expression of follicle stimulating hormone receptors in intra-tumoral vasculature and in tumoral cells - the involvement in tumour progression and the perspectives of application in cancer diagnosis and therapy.

Endokrynol Pol 2018 ;69(2):192-198

Uniwersytet Medyczny w Łodzi, Katedra Endokrynologii, Sterlinga 3, 91-414 Łódź, Poland.

In normal conditions follicle stimulating hormone receptors (FSHR) are expressed in zona granulosa cells of the ovary and Sertoli cells of the testis. However, the ectopic expression of FSHR was recently discovered in intra-tumoral blood vessels endothelia and/or in tumoral cells of many extra-gonadal human tumors (particularly in endocrine tumours). The paper reviews the data concerning the appearance of ectopic FSHR in particular human neoplasms. Read More

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http://dx.doi.org/10.5603/EP.2018.0022DOI Listing
October 2018
5 Reads

Sexual functioning and depressive symptoms in women with various types of prediabetes - a pilot study.

Endokrynol Pol 2018 ;69(2):175-181

Chair of Women's Health , Medical University of Silesia, Katowice.

Introduction: No previous study has investigated sexual functioning in prediabetic women.

Aim: This study was aimed at investigating sexual function in young women with various types of prediabetes.

Methods: The study included four groups of women: women with isolated impaired fasting glucose (Group A; n=19), isolated impaired glucose tolerance (Group B; n=18), presence of both impaired fasting glucose and impaired glucose tolerance (Group C; n=18), as well as matched healthy controls (Group D; n=19). Read More

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http://dx.doi.org/10.5603/EP.2018.0021DOI Listing
October 2018
1 Read

A follow-up study of patients with MEN syndromes - five case reports.

Endokrynol Pol 2018 ;69(2):163-167

Department of General and Endocrine Surgery School of Medicine with the Division of Dentistry in Zabrze Medical University of Silesia, Katowice, Poland, Batorego 15, 41-902 Bytom, Poland.

The Aim Of The Study: Evaluation of the results of surgical treatment in patients with hyperparathyroidism related to MEN syndrome MATERIALS AND METHODS: The group of three women and two men aged between 17 and 72 years ( av. 38.6) with MEN- related hyperparathyroidism within 419 patients were operated between 2010-2016. Read More

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http://dx.doi.org/10.5603/EP.2018.0020DOI Listing
October 2018
14 Reads

Serum sex hormones concentrations in young women in the early period after successful kidney transplantation.

Endokrynol Pol 2018 ;69(2):150-155

Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20-24, 40-027 Katowice, Poland.

Background: Hormonal disorders are frequently present in hemodialysed patients with chronic kidney disease (CKD). In women with CKD sex hormones abnormalities may lead to irregular, often anovulatory cycles, sexual dysfunction and infertility. Kidney transplantation done in young women tends to ameliorate most of the aforementioned disorders and improve fertility. Read More

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http://dx.doi.org/10.5603/EP.2018.0019DOI Listing
October 2018
3 Reads

Cystic pancreatic neuroendocrine tumours - a gastroenterologist's point of view.

Endokrynol Pol 2018 ;69(3):320-325

Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland, Poland.

Cystic pancreatic tumors are detected with increasing frequency and remain a clinical problem. Since they have different potential of malignancy the management and decision making process is a hard task. Guidelines, concerning pancreatic cystic tumors indicate the management with mucinous, serous cystic pancreatic neoplasms and solid pseudopappilary tumor, while the management with pancreatic cystic neuroendocrine tumors is not included into these standards. Read More

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http://dx.doi.org/10.5603/EP.2018.0034DOI Listing
October 2018
9 Reads

TeleNEN as a telemedicine model for neuroendocrine neoplasm management in case of Meckel's diverticulum NET.

Endokrynol Pol 2018 ;69(3):313-317

Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland.

A case of 25- years-old female with NET deriving from Meckel's diverticulum is described. The patient had one year history of dermatological skin problems. Ultrasound examination of abdomen performed because of arterial hypertension, revealed multiple hepatic lesions, which was confirmed in contrast enhanced CT. Read More

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http://dx.doi.org/10.5603/EP.2018.0033DOI Listing
October 2018
3 Reads

Thyroid hormones and obesity: a known but poorly understood relationship.

Endokrynol Pol 2018 ;69(3):292-303

Department of Biomedical Research, School of Medicine, Autonomous University of Queretaro Queretaro, Qro.; Mexico., Clavel 200; Col. Prados de la Capilla., 76170 Queretaro, Qro., Mexico.

Hormony tarczycy (thyroid hormones, TH) są zaangażowane w wiele różnych procesów biologicznych, wliczając rozwój układu nerwowego, regulację metabolizmu pośredniego oraz zużycie energii. Aktywnie uczestniczą w podstawowym zużyciu energii i termogenezie adaptacyjnej i z tego względu mogą mieć wpływ na masę ciała w przebiegu chorób tarczycy. Otyłość to niezakaźna, przewlekła, zapalna choroba metaboliczna, która implikuje dodatni bilans energetyczny. Read More

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http://dx.doi.org/10.5603/EP.2018.0032DOI Listing
October 2018
2 Reads

Th17 and IL-17 exhibit higher levels in osteonecrosis of the femoral head and have a positive correlation with severity of pain.

Endokrynol Pol 2018 ;69(3):283-290

Department of Orthopaedic Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766, Jingshi Road, Jinan, Shandong 250014, People's Republic of China, Jinan, China; Shandong University, School of Medicine, Jinan 250012, Shandong, P.R. China, Jinan, China.

Objective: Synovitis associated with osteonecrosis of the femoral head (ONFH) is responsible for several clinical symptoms. However, the mechanisms underlying synovitis and the inflammatory environment remain unclear. This study analyzed the proinflammatory mediation expression of IL-17 and Th17, which perform key functions in regulating inflammatory processes in the inflamed synovium and peripheral blood in ONFH. Read More

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http://dx.doi.org/10.5603/EP.a2018.0031DOI Listing
October 2018
8 Reads

Elevated serum lipocalin 2 levels are associated with indexes of both glucose and bone metabolism in type 2 diabetes mellitus.

Endokrynol Pol 2018 ;69(3):276-282

Introduction: The role of lipocalin 2 (LCN2) in type 2 diabetes mellitus (T2DM) needs to be fully elucidated. Moreover, bone has been demonstrated to modulate glucose metabolism via LCN2. We thus performed this study to investigate the associations of LCN2 with indexes of glucose metabolism in T2DM. Read More

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http://dx.doi.org/10.5603/EP.a2018.0030DOI Listing
October 2018
16 Reads

Study on the relationship between the methylation of the MMP-9 gene promoter region and diabetic nephropathy.

Endokrynol Pol 2018 ;69(3):269-275

Objective: This study aims to explore the relationship between the methylation of matrix metalloproteinase (MMP)-9 gene promoter region and diabetic nephropathy (DN) through the detection of the methylation level of MMP-9 gene promoter region in the peripheral blood of patients with DN in different periods and serum MMP-9 concentration.

Methods: The methylation level of the MMP-9 gene promoter region was detected by methylation-specific polymerase chain reaction (MSP), and the content of MMP-9 in serum was determined by enzyme-linked immunosorbent assay (ELISA).

Results: Results of the statistical analysis revealed that serum MMP-9 protein expression levels gradually increased in patients in the simple diabetic group, early diabetic nephropathy group and clinical diabetic nephropathy group, compared with the control group; and the difference was statistically significant (P < 0. Read More

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http://dx.doi.org/10.5603/EP.a2018.0029DOI Listing
October 2018
2 Reads

MIF/CD74 axis is a target for metformin therapy in diabetic podocytopathy - real world evidence.

Endokrynol Pol 2018 ;69(3):264-268

Shandong University, Jinan, China; Anhui Provincial Hospital.

Introduction:To observe the effects of metformin on urinary excretion of MIF, CD74 and podocalyxin in type 2 diabetics and to explore its possible renoprotective mechanisms.

Methods: 202 uncontrolled type 2 diabetics, who were previously prescribed sulfonylurea monotherapy(n=100) or sulfonylurea in combination with metformin (n=102) were enrolled in the study. The amount of macrophage migration inhibitory factor(MIF) and CD74 in serum, urinary MIF to creatine ratio(UMCR), urinary CD74 to creatine ratio(UCCR), urinary albumin to creatine ratio(UACR) and urinary podocalyxin to creatine ratio (UPCR) were determined. Read More

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http://dx.doi.org/10.5603/EP.a2018.0028DOI Listing
October 2018
2 Reads