2,901 results match your criteria Endokrynologia Polska[Journal]


Acromegaly associated with GIST, non-small cell lung cancer, clear cell renal cancer, myeloma multiplex, medulla oblongata tumor, adrenal adenoma and follicular thyroid nodules.

Endokrynol Pol 2019 Feb 11. Epub 2019 Feb 11.

Dept. of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Pasteura 4, 50-367 Wrocłąw, Poland.

Background: Acromegaly is associated with increased growth hormone (GH) and insulin-like growth factor-I (IGF-I) secretion which may support tumor development and growth.

Case Presentation: A 68-year old woman was diagnosed with acromegaly due to typical clinical and hormonal characteristics. While a contrast-enhanced MRI at diagnosis did not reveal a pituitary adenoma, a 5 mm lesion was identified on repeat scanning 13 months later. Read More

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http://dx.doi.org/10.5603/EP.a2019.0005DOI Listing
February 2019
5 Reads

The efficacy of microperimetry and contrast sensitivity test in the diagnosis of optic chiasm compression due to pituitary adenomas.

Endokrynol Pol 2019 Jan 30. Epub 2019 Jan 30.

Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Introduction: The aim of the study was to determine which microperimetry and contrast sensitivity test parameters would prove the most valuable during diagnosing optic chiasm compression due to pituitary adenomas.

Methods: Control group comprised healthy individuals (Group 1). Patients with pituitary macroadenoma were divided into two groups: Group 2 - absent optic chiasm compression, Group 3 - present optic chiasm compression detected on contrast-enhanced Magnetic Resonance Imaging (MRI). Read More

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http://dx.doi.org/10.5603/EP.a2019.0003DOI Listing
January 2019

Expression of α-Klotho protein in human thyroid cancers - an immunohistochemical study.

Endokrynol Pol 2019 Jan 30. Epub 2019 Jan 30.

Department of Neuroendocrinology, Interfaculty Chair of Laboratory and Molecular Medicine, Medical University of Lodz, Pomorska 251, 92-213 Łódź, Poland.

Background: The α-Klotho protein was discovered as a gene controlling the process of aging but the further studies indicated that it also plays a role of a tumour suppressor. Although the numerous studies were performed on the role of the α-Klotho gene and protein in neoplasia, the data on α-Klotho protein expression in thyroid cancers are very scarce. Our study presents the immunohistochemical investigation of α-Klotho expression in benign and malignant thyroid tumours. Read More

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http://dx.doi.org/10.5603/EP.a2019.0004DOI Listing
January 2019

Pernicious anemia and endocrine glands antibodies.

Endokrynol Pol 2019 Jan 16. Epub 2019 Jan 16.

Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

Introduction: The aim of the study was to determine the frequency of occurrence of antibodies participating in the development of endocrine diseases in patients with autoimmune hematopoietic disease, thus documenting the potential suitability of specific diagnostic and screening tests.

Material And Methods: The study group consisted of 124 persons (men and women) with newly diagnosed Pernicious Anemia (PA) and the control group (C) of 41 healthy people. Antibodies against: internal factor (IFAb), gastric parietal cells (APCA), thyroid peroxidase (TPOAb), thyroglobulin (TgAb), adrenal cortex (AdrenalAb) and pituitary anterior lobe (PituitaryAb) were determined in the blood. Read More

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http://dx.doi.org/10.5603/EP.a2018.0086DOI Listing
January 2019
2 Reads

Spatio-temporal image correlation (STIC) in evaluation of advanced neuroendocrine tumors.

Endokrynol Pol 2019 Jan 11. Epub 2019 Jan 11.

Klinika Endokrynologii i Nowotworów Neuroendokrynnych, Śląski Uniwersytet Medyczny w Katowicach, Ceglana 35, 40-514 Katowice, Poland.

Background: 4D Ultrasound technology merging Power Doppler option called High Definition Flow (HDF) with Spatio-Temporal Image Correlation (STIC) is used in gynecology and obstetrics. It seems to be a promising tool in assessing tissue vascularization.

Aim: To assess whether HDF STIC technique could be a useful tool for evaluation of gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) advancement. Read More

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http://dx.doi.org/10.5603/EP.a2019.0001DOI Listing
January 2019
1 Read

Novel inflammatory biomarkers may reflect subclinical inflammation in young healthy adults with obesity.

Endokrynol Pol 2019 Jan 11. Epub 2019 Jan 11.

2nd Department of Cardiology and Angiology, Silesian Center for Heart Diseases, Zabrze, Poland.

Introduction: Obesity is often accompanied by low-grade inflammation. In the last years a few blood-based inflammatory markers - neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and monocyte-to-high-density lipoprotein ratio (MHR) have been identified. They have been proven to correlate well with established inflammatory markers such as hsCRP, and have a prognostic value among others in patients with coronary artery disease, heart failure and malignancies. Read More

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http://dx.doi.org/10.5603/EP.a2019.0002DOI Listing
January 2019
2 Reads

V Congress of Polish Society of Neuroendocrinology 21-22 September, 2018 Kraków - Late abstracts.

Authors:
Late Abstracts

Endokrynol Pol 2018 ;69(6):742-745

V Congress of Polish Society of Neuroendocrinology 21-22 September, 2018 Kraków - Late abstracts. Read More

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January 2018
1 Read

Klotho protein function among patients with type 1 diabetes.

Endokrynol Pol 2018 ;69(6):696-704

Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Raszeja Hospital, Poznan, Poland.

The fibroblast growth factor 23 (FGF23) and Klotho system play a very important role in the regulation of the human body metabolism. On the one hand, they promote longevity, and on the other hand they promote insulin resistance. Nowadays, accelerated aging in diabetes as the main consequence of chronic complications of the disease is postulated. Read More

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http://dx.doi.org/10.5603/EP.a2018.0070DOI Listing
January 2018
2 Reads

List do Czytelników/Letter to Readers.

Authors:
Beata Kos-Kudła

Endokrynol Pol 2018 ;69(6):642-644

Słowo wstępne do "Endokrynologia Polska" 69 (6) 2018. Read More

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January 2018
1 Read

The effects of cannabinoids on the endocrine system.

Endokrynol Pol 2018 ;69(6):705-719

Chair and Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poland.

Cannabinoids are the derivatives of the cannabis plant, the most potent bioactive component of which is tetrahydrocannabinol (THC). The most commonly used drugs containing cannabinoids are marijuana, hashish, and hashish oil. These compounds exert their effects via interaction with the cannabinoid receptors CB1 and CB2. Read More

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http://dx.doi.org/10.5603/EP.a2018.0072DOI Listing
January 2018
2 Reads

Endocrine complications of cancer immunotherapy.

Endokrynol Pol 2018 ;69(6):722-733

Department of Nuclear Medicine and Endocrine Oncology, Maria Skłodowska-Curie Institute - Oncology Centre, Gliwice Branch, Gliwice, Poland.

Immunotherapy using monoclonal antibodies - checkpoint inhibitors - is a dynamically evolving discipline of clinical oncology and a new hope for patients with advanced and disseminated cancer. However, the activation of T-lymphocytes can at the same time lead to autoimmune response and destruction of healthy organs, which is a serious adverse effect that can also affect the endocrine system. Here we present possible endocrine complications of immunotherapy with contemporary inhibitors of immune checkpoints (CTLA-4, PD-1, PD-L1/L2), their frequency, symptoms, and proposed grade-dependent treatment. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.a2018.0073DOI Listing
January 2018
7 Reads

The effects of Z56822977 on biosynthesis of serotonin in the brain of rats in the conditions of MSG-induced obesity.

Endokrynol Pol 2018 ;69(5):536-544

Bogomolets National Medical University, T. Shevchenko boulevard, 13, Kyiv, Ukraine.

Wstęp: Badanie przeprowadzono w celu wyjaśnienia wpływu Z56822977 na biosyntezę serotoniny w mózgu szczurów z otyłością wy-wołaną podawaniem glutaminianu sodu (monosodium glutamate, MSG). Materiał i metody: W badaniu wykorzystano 18 samców szczura. Zwierzęta podzielono na trzy grupy: 1 - grupa kontrolna, 2 - grupa MSG, 3 - grupa MSG + Z56822977. Read More

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http://dx.doi.org/10.5603/EP.2018.0058DOI Listing
January 2018
3 Reads

List do Czytelników.

Authors:
Beata Kos Kudła

Endokrynol Pol 2018 ;69(5):464-465

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January 2018
1 Read

The influence of hypothyroidism and substitution treatment on thyroid hormone conversion ratios and rT3 concentration in patients with end-stage renal failure.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, ul. Banacha 1a, 02-097 Warsaw, Poland.

The increasing number of patients with end-stage renal disease (ESRD) requires seeking new opportunities to improve their quality of life not only because of kidney disease, but also due to other disturbances, such as thyroid hormone disorders. The aim of the study The objective of the study was to evaluate the influence of coexisting hypothyroidism and thyroid hormone therapy in patients with ESRD on thyroid hormone conversion ratios and rT3 concentration. Material and methods The study involved 85 patients aged 26 to 87 years, with a mean age of 59,62±15,45 years. Read More

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http://dx.doi.org/10.5603/EP.a2018.0087DOI Listing
November 2018
3 Reads

Subclinical hyperthyroidism in the course of autonomous nodules - clinical evaluation.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Katedra i Klinika Endokrynologii, Uniwersytet Medyczny w Lublinie, leje Racławickie 1, 20-059 Lublin, Poland.

Introduction Subclinical hyperthyroidism (SCH) also known as mildly symptomatic has recently been diagnosed more frequently. One of the main endogenous causes of this disorder is autonomously functioning thyroid nodule (AFTN). Despite the fact that it is usually asymptomatic SCH entails repercussions on the cardiovascular system and bone as well as carries a risk of progression to overt hyperthyroidism with a typical clinical picture. Read More

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http://dx.doi.org/10.5603/EP.a2018.0088DOI Listing
November 2018
15 Reads

Comparison of adipose tissue derived genes in endogenous Cushing's syndrome versus diet-induced obesity.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Division of Endocrinology, 2nd Department of Medicine, Hungarian Defense Forces - Military Hospital, Podmaniczky str. 111., 1062 Budapest, Hungary.

Introduction: Dysregulation of adipokine secretion and action are characteristic features of obesity that is a main clinical feature of Cushing's syndrome (CS). We have investigated whether endogenous glucocorticoid excess influences adipose tissue derived gene expression.

Material And Methods: mRNA expression of adipokines; adiponectin, resistin, tumor necrosis factor-, interleukin-6 (IL-6), angiotensinogen (AGT), plasminogen activator inhibitor type 1, retinol binding protein 4, visfatin, cystatin C was assessed by quantitative real-time RT-PCR in visceral adipose tissue removed during abdominal surgery of eight patients with CS, and six control patients. Read More

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http://dx.doi.org/10.5603/EP.a2018.0091DOI Listing
November 2018
4 Reads

Adropin in women with polycystic ovary syndrome.

Endokrynol Pol 2018 Dec 10. Epub 2018 Dec 10.

Wroclaw Medical University, Department of Endocrinology, Diabetes and Isothope Therapy, L. Pasteura 4, 50-367 Wroclaw, Poland.

Introduction: Women with polycystic ovary syndrome (PCOS) frequently develop metabolic complications. Among the new markers responsible for metabolic disorders, adropin seems to be of the great significance.

Material And Methods: 134 women aged 17-45 years were enrolled. Read More

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http://dx.doi.org/10.5603/EP.a2018.0092DOI Listing
December 2018
3 Reads

The association of thyroid-stimulating hormone (TSH) and free thyroxine (fT4) concentration levels with carbohydrate and lipid metabolism in obese and overweight teenagers.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Medical University of Gdansk, Department of Pediatrics, Diabetology and Endocrinology, ul Dębinki 7, 80-292 Gdańsk, Poland.

Introduction: Obesity has increased rapidly among children and adolescents during the last 30 years. Pediatric patients with a BMI >85th centile are more often diagnosed with increased TSH levels than children with proper body weight.

Materials And Methods: The data of 961 overweight and obese children, aged 13, recruited in four cities in Poland as part of PoZdro!, a two-year prophylactic program, were analysed to observe the relationship between serum TSH and fT4 concentration and carbohydrate and lipid metabolism parameters, as well as anthropometric parameters. Read More

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http://dx.doi.org/10.5603/EP.a2018.0090DOI Listing
November 2018
10 Reads

[Tc]-99m thyroid scintigraphy in more than 210 cases of permanent congenital hypothyroidism and its correlation with the 1st diagnostic serum thyrotropin.

Authors:
Majid Aminzadeh

Endokrynol Pol 2018 Nov 19. Epub 2018 Nov 19.

Objective: A big part of cases of congenital hypothyroidism(CH) in Iran are transient. This study designed to investigate etiology of permanent CH(PCH) by thyroid scintigraphy(TS) and its relationship with the first diagnostic thyrotropin(TSH).

Methods: During twelve years (2005-2017) of CH screening in southwest Iran, all infants referred with the diagnosis of CH were followed until the 3rd birthday that they were reevaluated for serum T4,TSH after 3-4 weeks treatment discontinuation. Read More

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http://dx.doi.org/10.5603/EP.a2018.0083DOI Listing
November 2018
13 Reads

RESISTANCE TO THYROID HORMONE WITH A MUTATION OF THE THYROID β RECEPTOR GENE IN AN EIGHT-MONTH OLD INFANT: CASE REPORT.

Endokrynol Pol 2018 Nov 19. Epub 2018 Nov 19.

Katedra i Klinika Pediatrii i Endokrynologii Dziecięcej Śląskiego Uniwersytetu Medycznego w Katowicach, ul. Medyków 16, 40-752 Katowice, Poland.

Introduction: Resistance to thyroid hormone (RTHβ) is a rare syndrome of impaired tissue responsiveness to thyroid hormones (THs). The disorder has autosomal dominant or recessive pattern of inheritance. Most of reported mutations have been detected in the thyroid hormone receptor β gene (THRB). Read More

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http://dx.doi.org/10.5603/EP.a2018.0082DOI Listing
November 2018
8 Reads

The role of adiponectin and leptin in the treatment of ovarian cancer patients.

Endokrynol Pol 2018 Nov 19. Epub 2018 Nov 19.

Oncological Ward, Independent Public Health Care Unit, Voivodeship Specialized Hospital No 3, Energetyków 46 Str., 44-200 Rybnik, Poland.

Introduction: Ovarian cancer is most frequently detected in the advanced stage. Although its pathogenesis is not fully elucidated, it is assumed that body susceptibility and hormonal disorders are responsible. The role of some cytokines as predictors in the treatment process is still investigated. Read More

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http://dx.doi.org/10.5603/EP.a2018.0081DOI Listing
November 2018
9 Reads

Clinical case seminar: Familial intracranial germinoma.

Endokrynol Pol 2018 ;69(5):612-618

Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Belgrade, Serbia, Serbia and Montenegro; University of Belgrade, School of Medicine, Belgrade, Serbia.

Background: Intracranial germinomas (ICG) are uncommon brain neoplasms with extremely rare familial occurance. Since ICG invades hypothalamus and/or pituitary, the endocrine dysfunction is one of the common determinants of these tumors. We presented two brothers with the history of ICG. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.2018.0060DOI Listing
January 2018
16 Reads

Endocrine implications of obesity and bariatric surgery.

Endokrynol Pol 2018 ;69(5):574-597

Department of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Krakow, Poland.

Introduction: Obesity is a highly prevalent disease in the world associated with the disorders of endocrine system. Recently, it may be concluded that the only effective treatment of obesity remains bariatric surgery. The aim of the review was to compare the concepts of appetite hormonal regulation, reasons of obesity development and bariatric procedures published over the last decade. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.2018.0059DOI Listing
January 2018
5 Reads

Capecitabine plus temozolomide in well or moderately differentiated primary atypical neuroendocrine tumors: a single centre experience of two cases.

Endokrynol Pol 2018 Oct 25. Epub 2018 Oct 25.

San Luigi Gonzaga Hospital, Regione Gonzole 10, 10043 Turin, Italy.

Introduction: Neuroendocrine neoplasms (NENs) are a rare and heterogeneous group of tumors, with a variety of primary origins and variable aggressiveness. NENs with an atypical primary origin, such as breast and retroperitoneal NENs, are extremely rare. As a consequence, an established diagnostic and therapeutic strategy in this particular subgroup is lacking. Read More

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http://dx.doi.org/10.5603/EP.a2018.0076DOI Listing
October 2018
1 Read

Endothelin-1 (ET-1), N-terminal fragment of proatrial natriuretic peptide (NTpro-ANP) and tumor necrosis factor alpha (TNF-α) in children with primary hypertension and hypertension of renal origin.

Endokrynol Pol 2018 Oct 25. Epub 2018 Oct 25.

Department of Paediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13-15, 41-800 Zabrze, Poland.

Introduction Hypertension is regarded to be a condition of mild inflammation and endothelial imbalance. The aim of the study was to evaluate serum concentrations of biomarkers of inflammation and endothelial function: tumor necrosis factor alpha (TNF-α), endothelin-1 (ET-1) and N-terminal fragment of proatrial natriuretic peptide (NTpro-ANP) in hypertensive and normotensive children. Material and methods We studied 63 children aged 13,56 ± 3,73 years, divided into: group with primary hypertension (n=50) and group with renal hypertension (n=13). Read More

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http://dx.doi.org/10.5603/EP.a2018.0079DOI Listing
October 2018
1 Read

Intracerebral hemorrhage as a first sign of pheochromocytoma: case report and review of the literature.

Endokrynol Pol 2018 Oct 23. Epub 2018 Oct 23.

Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center, Belgrade, Serbia; Medical Faculty, University of Belgrade, Belgrade, Serbia.

Pheochromocytomas and sympathetic paragangliomas are rare catecholamine-secreting tumors and represent very rare causes of intracerebral hemorrhage in young, with only few cases reported. A 32-year-old man presented to our emergency department because of sudden onset of severe headache. He had a six months history of paroxysmal headache, palpitations and sweating. Read More

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http://dx.doi.org/10.5603/EP.a2018.0075DOI Listing
October 2018
14 Reads

Treatment of severe primary IGF-1 deficiency using rhIGF-1 preparation - first three years of Polish experience.

Endokrynol Pol 2018 Oct 23. Epub 2018 Oct 23.

Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland, Poland.

Introduction: The objective of this study was to analyze the effects of the first three years of treatment with recombinant human insulin-like growth factor 1 (rhIGF-1) in patients from the Polish population.

Material And Methods: Twenty-seven children (22 boys and 5 girls) aged 2.8 to 16. Read More

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http://dx.doi.org/10.5603/EP.a2018.0074DOI Listing
October 2018
6 Reads

Sexual function and depressive symptoms in men with overt hyperthyroidism.

Endokrynol Pol 2018 Oct 11. Epub 2018 Oct 11.

Introduction: Although hyperthyroidism is characterized by female predominance, its presence may lead to the development of numerous complications in both sexes. This study was aimed at investigating sexual function and depressive symptoms in men with overt hyperthyroidism of autoimmune and non-autoimmune origin.

Material And Methods: The study population consisted of three age-matched groups: men with overt hyperthyroidism and Graves' disease (group A; n=20), men with overt hyperthyroidism and toxic multinodular goiter or toxic adenoma (group B; n=21) and men with normal thyroid function (group C; n=23). Read More

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http://dx.doi.org/10.5603/EP.a2018.0069DOI Listing
October 2018
3 Reads

False-positive radioiodine whole-body scan due to a renal cyst.

Endokrynol Pol 2018 11;69(6):736-739. Epub 2018 Oct 11.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Patients affected by differentiated thyroid cancer are treated surgically and by ablative radioiodine therapy. A post-therapy whole-body scan allows detection of thyroid remnants or local and distant metastases, although false-positive findings may be observed. We report a case of a 75-year-old woman with follicular thyroid cancer, who underwent ablative radioiodine treatment. Read More

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http://dx.doi.org/10.5603/EP.a2018.0071DOI Listing
October 2018
5 Reads

The effect of short-term perindopril and telmisartan treatment on circulating levels of anti-inflammatory cytokines in hypertensive patients.

Endokrynol Pol 2018 27;69(6):667-674. Epub 2018 Sep 27.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Introduction: Both angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers were found to reduce plasma levels of proinflammatory cytokines. No previous study has compared their effect on the production of anti-inflammatory cytokines.

Material And Methods: The study enrolled 52 patients with grade 1 and grade 2 arterial hypertension. Read More

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http://dx.doi.org/10.5603/EP.a2018.0068DOI Listing
September 2018
2 Reads

Serum metalloproteinase concentration might be a new predictor of cardiovascular risk in obese women.

Endokrynol Pol 2018 Sep 27. Epub 2018 Sep 27.

1st Department of Obstetrics and Gynegology, 1st Faculty of Medicine, Medical University of Warsaw, Starynkiewicza Sq. 1/3, 02-015 Warsaw, Poland.

Objective: Increased levels and activity of some MMPs are described in obesity-related vascular diseases. Factors that influence MMPs blood concentration are still investigated. This research aim to evaluate the concentration of most types of MMPs: collagenases (MMP-1,-3,-8,-13), matrilisine (MMP-7), gelatinase (MMP-9) and malloelsastase (MMP-12) in serum of women in reproductive age in relation with their body mass index (BMI), age, estradiol and progesterone concentrations. Read More

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http://dx.doi.org/10.5603/EP.a2018.0067DOI Listing
September 2018
1 Read

Oncocytic neoplasms; rare adrenocortical tumours - a report of eleven patients.

Endokrynol Pol 2018 27;69(6):682-687. Epub 2018 Sep 27.

Department of Internal Medicine, Division of Endocrinology and Metabolism, Kastamonu State Hospital, Kastamonu, Turkey.

Introduction: Oncocytomas of adrenal glands are extremely rare and usually present as incidentally detected masses. We aimed to present a series of patients with adrenal oncocytomas and review the literature.

Material And Methods: Electronic database of patients with adrenal tumours, who were admitted to the internal medicine and endocrinology and metabolism outpatient clinics of Uludag University Medical Faculty between January 2005 and November 2016, were assessed retrospectively. Read More

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http://dx.doi.org/10.5603/EP.a2018.0066DOI Listing
September 2018
2 Reads

Vitamin D status including 3-epi-25(OH)D3 among adult patients with thyroid disorders during summer months.

Endokrynol Pol 2018 27;69(6):653-660. Epub 2018 Sep 27.

Department of Endocrinology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland.

Introduction: In the context of pleiotropic vitamin D effects, its role has also been investigated in thyroid pathology, in particular autoimmune thyroid diseases (AITD). However, available data concerning vitamin D status in Polish patients with thyroid disorders are inconclusive. In the study we investigated vitamin D status and adequacy of supplementation, as well as sunlight exposure during summer months among adult patients with thyroid diseases. Read More

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http://dx.doi.org/10.5603/EP.a2018.0065DOI Listing
September 2018
4 Reads

The importance of combined NGS and MLPA genetic tests for differential diagnosis of Maturity onset diabetes of the young.

Endokrynol Pol 2018 Sep 27. Epub 2018 Sep 27.

Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 444a, 11010 Belgrade, Serbia and Montenegro.

Introduction: Maturity onset diabetes of the young (MODY) is a rare form of monogenic diabetes. Being clinically and genetically heterogeneous, it is often misdiagnosed as type 1 or type 2 diabetes, leading to inappropriate therapy. MODY is caused by a single gene mutation. Read More

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http://dx.doi.org/10.5603/EP.a2018.0064DOI Listing
September 2018
11 Reads

Detection of new potentially pathogenic mutations in two patients with primary pigmented nodular adrenocortical disease (PPNAD) - case reports with literature review.

Endokrynol Pol 2018 27;69(6):675-681. Epub 2018 Sep 27.

Department of Endocrinology and Diabetology, The Children's Memorial Health Institute, Warsaw, Poland.

Introduction: Primary pigmented nodular adrenocortical disease (PPNAD) is a rare form of ACTH-independent Cushing's syndrome (CS). Half of patients with PPNAD are sporadic cases and the other half familial.

Material And Methods: We present two patients with PPNAD confirmed by genetic analysis. Read More

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http://dx.doi.org/10.5603/EP.a2018.0063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347113PMC
September 2018
5 Reads

The effect of atorvastatin on sexual function and depressive symptoms in young women with elevated cholesterol levels - a pilot study.

Endokrynol Pol 2018 27;69(6):688-694. Epub 2018 Sep 27.

Chair of Woman's Health, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.

Introduction: Statins were found to improve erectile function in men. No previous study has prospectively investigated sexual functioning in women receiving these agents. The aim of this study was to evaluate the impact of atorvastatin therapy on female sexual function, and depressive symptoms in young women with elevated cholesterol levels. Read More

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http://dx.doi.org/10.5603/EP.a2018.0062DOI Listing
September 2018
8 Reads

Determinants of obesity in population of PURE study from Lower Silesia.

Endokrynol Pol 2018 19;69(6):644-652. Epub 2018 Sep 19.

Department of Endocrinology, Diabetes and Isothope Therapy, Wroclaw Medical University, Wroclaw, Poland.

Introduction: The knowledge about obesity pathogenesis is insufficient. The aim of our study was to investigate environmental and individual determinants of obesity in population of PURE study from Lower Silesia.

Material And Methods: This was a cross sectional observation of 1064 inhabitants of Wroclaw and neighbouring rural area (671 women, 393 men), who took part in PURE study in years 2007-2010. Read More

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http://dx.doi.org/10.5603/EP.a2018.0061DOI Listing
September 2018
8 Reads

Serum progranulin levels are elevated in infertile women with obesity.

Endokrynol Pol 2018 19;69(6):661-666. Epub 2018 Sep 19.

Konya Education and Research Hospital, Konya, Turkey.

Introduction: The aim of the present study was to investigate the changes in serum progranulin and sex hormone levels in infertile women with obesity.

Material And Methods: A total of 171 infertile women who had fertility desire were included in this cross-sectional study. The initial assessment included measurements of weight, height, waist circumference, and hip circumference to calculate body mass index (BMI) and waist/hip ratio. Read More

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http://dx.doi.org/10.5603/EP.a2018.0044DOI Listing
September 2018
3 Reads

Pharmacotherapy of obesity - state of the art.

Endokrynol Pol 2018 ;69(4)

Medical University of Lublin.

Obesity, which affects about 13% of the world population, results in significant deterioration of health and serious clinical, mainly meta-bolic and cardiovascular complications. Although the basis of therapeutic treatment is behavioural treatment, often non-pharmacological effects do not produce the desired effect. Currently there are several drugs with a safe action profile that improve the effect of treatment (5-10% weight reduction). Read More

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http://dx.doi.org/10.5603/EP.2018.0048DOI Listing
December 2018
3 Reads

A review of cardiovascular outcome trials in type 2 diabetes.

Endokrynol Pol 2018 ;69(4)

Type 2 diabetes is a complex metabolic disorder associated with a high risk of cardiovascular complications. In December 2008, due to concerns about the cardiac safety of antihyperglycaemic therapies, the Food and Drug Administration (FDA) published a new guidance on special requirements for the demonstration of cardiovascular safety for these medications. In 2012, similar recommendations were made for antidiabetic drug manufacturers by the European Medicines Agency (EMA). Read More

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http://dx.doi.org/10.5603/EP.2018.0053DOI Listing
December 2018
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Management of Prader-Willi Syndrome (PWS) in adults - what an endocrinologist needs to know. Recommendations of the Polish Society of Endocrinology and the Polish Society of Paediatric Endocrinology and Diabetology.

Endokrynol Pol 2018 ;69(4)

Prader-Willi syndrome (PWS) is a complex genetic disorder characterised by a set of phenotypic traits, which include infantile hypotonia, short stature, and morbid obesity. Over the last 12 years, visible progress has been made in medical care management of PWS patients in Poland. Increasing awareness of the disorder in neonatal and paediatric care has led to early identification of the condition in neonates, followed by the institution of an appropriate dietary regime, introduction of physiotherapy, and early-onset recombinant human growth hormone (rhGH) treatment. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.2018.0047DOI Listing
December 2018
15 Reads

The polycystic ovary syndrome: a position statement from the Polish Society of Endocrinology, the Polish Society of Gynaecologists and Obstetricians, and the Polish Society of Gynaecological Endocrinology.

Endokrynol Pol 2018 ;69(4)

Katedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami Uniwersytetu Medycznego im. Piastów Śląskich we Wrocławiu.

Polycystic ovary syndrome (PCOS) diagnosis and therapy still arouse a lot of controversy. Each year brings new information, so, having collected the experience of three scientific societies, we present contemporary recommendations concerning PCOS diagnostics and treat-ment. In adult female diagnosis, we still use the Rotterdam criteria, which is two out of three of the follwing characteristics: a) ovulation abnormality, b) clinical or biochemical hyperandrogenism, and c) polycystic ovaries. Read More

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http://dx.doi.org/10.5603/EP.2018.0046DOI Listing
December 2018
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LanroNET - A Non-Interventional Prospective Study to Assess the Resource Utilisation and Cost of Lanreotide Autogel 120 mg in the Population of Polish Patients with Symptomatic Neuroendocrine Tumours.

Endokrynol Pol 2018 22;69(5):567-573. Epub 2018 Aug 22.

Ipsen Poland, 29th Jana Pawła II St., 00-867 Warsaw, Poland.

Wstęp: Celem badania LanroNET była ocena wykorzystania zasobów medycznych oraz kosztów objawowego leczenia polskich chorych na nowotwory neuroendokrynne z zastosowaniem lanreotydu autogel 120 mg. Materiał i metody: LanroNET to wieloośrodkowe, nieinterwencyjne, obserwacyjne, prospektywne badanie przeprowadzone w 12 ośrod-kach w Polsce. W badaniu uczestniczyli dorośli chorzy na wydzielające nowotwory neuroendokrynne leczeni lanreotydem autogel 120 mg od przynajmniej 3 miesięcy przed włączeniem do badania. Read More

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http://dx.doi.org/10.5603/EP.a2018.0057DOI Listing
August 2018
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Alterations in thyroid hormones in brain-dead patients are related to non-thyroidal illness syndrome.

Endokrynol Pol 2018 22;69(5):545-549. Epub 2018 Aug 22.

Department of Internal Medicine, Section of Critical Care, School of Medicine, Düzce University, Düzce, Turkey.

Introduction: Alterations in thyroid hormone levels occur in patients with acute neurological disease states. The aim of this study is to study changes in thyroid hormones in patients with brain death (BD).

Material And Methods: Eleven brain-dead patients were studied prospectively. Read More

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http://dx.doi.org/10.5603/EP.a2018.0056DOI Listing
August 2018
10 Reads

Plasma adiponectin array in women with Alzheimer's disease.

Endokrynol Pol 2018 17;69(5):550-559. Epub 2018 Aug 17.

Department of Neuroendocrinology, Centre of Postgraduate Medical Education, Marymoncka 99/103, 01-813 Warsaw, Poland.

Introduction Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. Typical features of AD include memory loss, social dysfunction and physical impairment. Although the pathological findings in the central nervous system are well established, the etiological factors are poorly known. Read More

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http://dx.doi.org/10.5603/EP.a2018.0055DOI Listing
August 2018
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National Program of Severe Growth Hormone Deficiency Treatment in Adults and Adolescents after Completion of Growth Promoting Therapy.

Endokrynol Pol 2018 17;69(5):468-524. Epub 2018 Aug 17.

Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Polish Mother's Memorial Hospital - Research Institute, Lodz, Lodz, Poland; Department of Oncological Endocrinology, Medical University of Lodz, Poland.

Growth hormone (GH) has been used in the treatment of short stature in children with GH deficiency (GHD) for 60 years, and for about 30 years also in the treatment of adults with GHD, in whom such treatment is carried out due to metabolic indications. In Poland, GH treatment is reimbursed only in children with GHD, while so far it has not been refunded in adults with GHD. There are two groups of adults (or adolescents after growth completion) with GHD, who require GH therapy: patients with GHD that occurred in childhood (childhood-onset GHD - CO-GHD) and patients with GHD acquired in adulthood (adulthood-onset GHD - AO-GHD). Read More

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http://dx.doi.org/10.5603/EP.a2018.0054DOI Listing
August 2018
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Chromogranin A and its role in the pathogenesis of diabetes mellitus.

Endokrynol Pol 2018 3;69(5):598-610. Epub 2018 Aug 3.

Semmelweis University, 2nd Department of Internal Medicine, Szentkiralyi u. 46., H-1088 Budapest, Hungary.

Chromogranin A is a member of the granin glycoprotein family that is expressed by the endocrine and neuroendocrine cells of different organs. Intracellularly, chromogranin A contributes to the regulation of secretion and gives several cleavage products after secretion. Some of its cleavage products modify the hormone functions in autocrine and paracrine ways, while the functions of others have not been fully understood yet. Read More

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http://dx.doi.org/10.5603/EP.a2018.0052DOI Listing
August 2018
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The role of the cAMP/PKA signalling pathway in the inhibitory influence of melatonin on oxytocin and vasopressin secretion from the rat hypothalamo-neurohypophysial system.

Endokrynol Pol 2018 3;69(5):560-566. Epub 2018 Aug 3.

Department of Pathophysiology and Experimental Neuroendocrinology, Medical University of Lodz, ul. Narutowicza 60, 90-136 Lodz, Poland.

Introduction: Melatonin was found to inhibit forskolin-stimulated oxytocin (OT) and vasopressin (VP) release in vitro. The purpose of the present investigation was to evaluate the contribution of the cyclic 3',5'-adenosine monophosphate/protein kinase A (cAMP/PKA) signalling pathway in melatonin-dependent inhibition of OT and VP secretion from the rat hypothalamo-neurohypophysial (H-NH) system in vitro.

Material And Methods: The H-NH explants were placed in 1 ml of normal Krebs-Ringer (nK-R) buffer and first preincubated for 30 min in control buffer or in the presence of PKA inhibitor, i. Read More

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http://dx.doi.org/10.5603/EP.a2018.0051DOI Listing
August 2018
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The relation of pituitary adenomas invasiveness and the proliferative index measured by immunoexpression of topoisomerase IIα.

Endokrynol Pol 2018 3;69(5):530-535. Epub 2018 Aug 3.

Chair and Department of Endocrinology, Jagiellonian University Medical College, Kopernika 17, 31-501 Kraków, Poland.

Introduction: Cavernous sinus invasion by pituitary adenoma affects surgical procedure radicality and consequently the postoperative course and prognosis in pituitary adenoma treatment. The search for pituitary adenoma aggressive behaviour markers is still a matter of debate.

Material And Methods: This study evaluates the relation of pituitary adenoma invasiveness to the expression of topoisomerase IIα in 72 patients who underwent transsphenoidal pituitary surgery. Read More

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http://dx.doi.org/10.5603/EP.a2018.0050DOI Listing
August 2018
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Blood serum concentrations of gonadotropins and α-subunit in patients with gonadotropinomas in relation to the immunoreactivity of pituitary adenoma.

Endokrynol Pol 2018 3;69(5):526-529. Epub 2018 Aug 3.

Department of Immunoendocrinology. Chair of Endocrinology, Medical University of Lodz, Sterling Str. 1/3, 91-425 Lodż, Poland.

Introduction: Although active gonadotropin-secreting pituitary adenomas are considered very rare, the vast majority of pituitary tumours diagnosed as "non-functioning" express gonadotropins or their free β or α subunits. However, systemic investigations comparing the serum concentrations of follitropin (FSH), lutropin (LH), and α-subunit (αSU) before surgery with the immunoreactivity of the respective substances in the excised tumours are still lacking.

Material And Methods: Immunostaining of FSH, LH, and αSU was compared in 43 surgically removed gonadotropin - expressing pitu-itary adenomas with serum concentrations of the above-mentioned substances before surgery in the same patients. Read More

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http://dx.doi.org/10.5603/EP.a2018.0049DOI Listing
August 2018
7 Reads