38,794 results match your criteria Endocrinology[Journal]


T cells in gut linked to metabolism.

Authors:
Alan Morris

Nat Rev Endocrinol 2019 Feb 15. Epub 2019 Feb 15.

Nature Reviews Endocrinology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41574-019-0177-7DOI Listing
February 2019

Dynamics of ACTH-mediated regulation of gene transcription in ATC1 and ATC7 adrenal zona fasciculata cell lines.

Endocrinology 2019 Feb 15. Epub 2019 Feb 15.

Bristol Medical School: Translational Health Sciences, University of Bristol, Bristol, UK.

We tested the hypothesis that mouse ATC1 and ATC7 cells, the first adrenocortical cell lines to exhibit a complete ZF cell phenotype, respond to dynamic ACTH stimulation in a similar manner as the adrenal gland in vivo. Exploiting our previous in vivo observations that gene transcription within the steroidogenic pathway is dynamically regulated in response to a pulse of ACTH, we exposed ATC1 and ATC7 cells to various patterns of ACTH, including pulsatile and constant, and measured the transcriptional activation of this pathway. We show that pulses of ACTH administered to ATC7 cells can reliably stimulate a pulsatile pattern of transcriptional activity that is comparable to that observed in adrenal ZF cells in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00840DOI Listing
February 2019

Balancing glucose levels after bariatric surgery - an important role for GLP1.

Authors:
Claire Greenhill

Nat Rev Endocrinol 2019 Feb 14. Epub 2019 Feb 14.

Nature Reviews Endocrinology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41574-019-0178-6DOI Listing
February 2019

Teaching Endocrinology-The Highest Calling.

Endocrinology 2019 Mar;160(3):534-535

Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2019-00082DOI Listing

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism.

Nat Rev Endocrinol 2019 Feb 13. Epub 2019 Feb 13.

Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

Gut hormones have many key roles in the control of metabolism, as they target diverse tissues involved in the control of intestinal function, insulin secretion, nutrient assimilation and food intake. Produced by scattered cells found along the length of the intestinal epithelium, gut hormones generate signals related to the rate of nutrient absorption, the composition of the luminal milieu and the integrity of the epithelial barrier. Gut hormones already form the basis for existing and developing therapeutics for type 2 diabetes mellitus and obesity, exemplified by the licensed glucagon-like peptide 1 (GLP1) mimetics and dipeptidyl peptidase inhibitors that enhance GLP1 receptor activation. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41574-019-0168-8
Publisher Site
http://dx.doi.org/10.1038/s41574-019-0168-8DOI Listing
February 2019
5 Reads

CRISP2 is a regulator of multiple aspects of sperm function and male fertility.

Endocrinology 2019 Feb 13. Epub 2019 Feb 13.

The Department of Anatomy and Developmental Biology, Monash University, Australia.

The Cysteine-RIch Secretory Proteins (CRISPs) are a group of proteins which show a pronounced expression biased to the male reproductive tract. While sperm encounter CRISPs at virtually all phases of sperm development and maturation, CRISP2 is the sole CRISP produced during spermatogenesis, wherein it is incorporated into the developing sperm head and tail. Within this study we test the necessity for CRISP2 in male fertility using Crisp2 loss-of-function mouse models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-01076DOI Listing
February 2019

In vivo ablation of the conserved GATA binding motif in the Amh promoter impairs Amh expression in the male mouse.

Endocrinology 2019 Feb 13. Epub 2019 Feb 13.

Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval and Centre de recherche en reproduction, développement et santé intergénérationnelle (CRDSI), Quebec, Canada.

GATA4 is an essential transcriptional regulator required for gonadal development, differentiation, and function. In the developing testis, proposed GATA4-regulated genes include steroidogenic factor 1 (Nr5a1), SRY-related HMG box 9 (Sox9), and anti-Müllerian hormone (Amh). While some of these genes have been validated as genuine GATA4 targets, it remains unclear whether GATA4 is a direct regulator of endogenous Amh transcription. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2019-00047DOI Listing
February 2019

Transcription factor USF1 is required for maintenance of germline stem cells in male mice.

Endocrinology 2019 Feb 13. Epub 2019 Feb 13.

Genome-Scale Biology Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

A prerequisite for lifelong sperm production is that spermatogonial stem cells (SSCs) balance self-renewal and differentiation, yet factors required for this balance remain largely undefined. Using mouse genetics, we now demonstrate that the ubiquitously expressed transcription factor USF1 (Upstream stimulatory factor 1) is critical for the maintenance of SSCs. We show that USF1 is not only detected in Sertoli cells as previously reported, but also in SSCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-01088DOI Listing
February 2019
1 Read

Tamoxifen improves glucose tolerance in a delivery, sex, and strain-dependent manner in mice.

Endocrinology 2019 Feb 12. Epub 2019 Feb 12.

Department of Biology, Johns Hopkins University, Baltimore, MD, USA.

Tamoxifen, a selective estrogen receptor modulator, is widely used in mouse models to temporally control gene expression but is also known to affect body composition. Here, we report that tamoxifen has significant and sustained effects on glucose tolerance, independent of effects on insulin sensitivity, in mice. Intraperitoneal, but not oral, tamoxifen delivery improved glucose tolerance in three inbred mouse strains. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00985DOI Listing
February 2019

Estradiol Replacement Timing and Obesogenic Diet Effects on Body Composition and Metabolism in Post-menopausal Macaques.

Endocrinology 2019 Feb 7. Epub 2019 Feb 7.

Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.

Whether hormone replacement therapy has beneficial metabolic effects in postmenopausal women remains controversial due to between-study differences in menopausal duration, estrogen formulations, and diet. Additionally, animal studies have not reflected the typical human obesogenic, Western-Style Diet (WSD). In this study, we determined the effects of immediate E (ImE) or delayed E treatment on weight and metabolism parameters in old ovo-hysterectomized rhesus macaques consuming a WSD over a 30-month period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00884DOI Listing
February 2019
2 Reads

Glutamatergic Neurokinin 3 receptor neurons in the median preoptic nucleus modulate heat-defense pathways in female mice.

Endocrinology 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology, University of Arizona College of Medicine, Tucson, Arizona.

We have proposed that KNDy (kisspeptin/neurokinin B/dynorphin) neurons contribute to hot flushes via projections to neurokinin 3 receptor (NK3R) expressing neurons in the median preoptic nucleus (MnPO). To characterize the thermoregulatory role of MnPO NK3R neurons in female mice, we ablated these neurons using injections of saporin toxin conjugated to a selective NK3R agonist. Loss of MnPO NK3R neurons increased core temperature (TCORE) during the light phase, with frequency distributions indicating a regulated shift in the balance point. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00934DOI Listing
February 2019

Next Generation ERα Inhibitors for Endocrine-Resistant ER+ Breast Cancers.

Endocrinology 2019 Feb 8. Epub 2019 Feb 8.

Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL.

One in eight women will be diagnosed with breast cancer in their lifetime. Because estrogen receptor alpha (ERα) is expressed in approximately 70% of patients, therapeutic intervention by ERα-targeted endocrine therapies remains the leading strategy to prevent progression/metastasis in the adjuvant setting. However, the efficacy of these therapies is diminished by the development of acquired resistance following prolonged treatment regiments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-01095DOI Listing
February 2019
1 Read

Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro.

Endocrinology 2019 Feb 8. Epub 2019 Feb 8.

Fertility and Research Centre, School of Women's and Children's Health, University of New South Wales Sydney, Australia.

The oocyte-secreted factors bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) interact functionally and it is hypothesised that this interaction may be mediated by formation of a GDF9:BMP15 heterodimer, termed cumulin. GDF9 and BMP15 regulate folliculogenesis and ovulation rate, and have been shown to regulate inhibin and activin, local regulators of folliculogenesis. The objective of this study was to determine if cumulin regulates granulosa cell inhibin and activin production, and if this requires cooperation with FSH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-01026DOI Listing
February 2019

Membrane androgen receptors unrelated to nuclear steroid receptors.

Authors:
Peter Thomas

Endocrinology 2019 Feb 11. Epub 2019 Feb 11.

The University of Texas at Austin, Marine Science Institute, Port Aransas, Texas, USA.

Rapid (nongenomic) membrane-initiated androgen actions have been described in nuclear androgen (AR) receptor-null cells. Four distinct proteins have been proposed as membrane androgen receptors (mAR) or sensors. TRPM8 is a calcium channel that acts as a pain receptor and mediates androgen- and menthol-induced increases in calcium levels and survival of prostate cancer cells. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/endo/advance-article/doi/10.1210/en
Publisher Site
http://dx.doi.org/10.1210/en.2018-00987DOI Listing
February 2019
2 Reads

Islets form as peninsulas.

Authors:
Shimona Starling

Nat Rev Endocrinol 2019 Feb 8. Epub 2019 Feb 8.

Nature Reviews Endocrinology, .

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41574-019-0172-z
Publisher Site
http://dx.doi.org/10.1038/s41574-019-0172-zDOI Listing
February 2019
3 Reads

Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus.

Nat Rev Endocrinol 2019 Feb 7. Epub 2019 Feb 7.

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Adipose tissue comprises adipocytes and many other cell types that engage in dynamic crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has been studied for decades, it has been appreciated only in the past 5 years that extensive arborization of nerve fibres has a dominant role in regulating the function of adipose tissue. This Review summarizes the latest literature, which suggests that adipocytes signal to local sensory nerve fibres in response to perturbations in lipolysis and lipogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41574-019-0165-yDOI Listing
February 2019
1 Read

Aldosterone Modulates the Mechanistic Target of Rapamycin (mTOR) Signaling in Male Mice.

Endocrinology 2019 Feb 6. Epub 2019 Feb 6.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, United States of America.

Both mechanistic target of rapamycin (mTOR) pathway and aldosterone are implicated in the development of cardiovascular and renal disease. However, the interaction between aldosterone and the mTOR pathway is unknown.We hypothesized that: 1) increased aldosterone will modulate the activity of the mTORC1 and mTORC2 molecular pathways in the heart and kidney; 2) a physiologic increase in aldosterone will affect these pathways differently than a pathophysiologic one; and 3) the changes in the mTOR level/activity will differ between the heart and kidney. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00989DOI Listing
February 2019
1 Read

Genetic factors associated with human physical activity: Are your genes too tight to prevent you exercising?

Endocrinology 2019 Feb 5. Epub 2019 Feb 5.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, PRC.

The benefits of physical activity (PA) on health and fitness are well known. Recently, it has become apparent from studies of heritability that there is a considerable genetic component to PA. However, PA is such complex phenotype that the measurement and quantification of it provide a challenge to a clearer understanding of its genetic basis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00873DOI Listing
February 2019
1 Read

A healthy lifestyle - reducing T2DM risk in shift workers?

Nat Rev Endocrinol 2019 Feb 4. Epub 2019 Feb 4.

Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41574-019-0164-zDOI Listing
February 2019
2 Reads

Study of human T21 placenta suggests a potential role of mesenchymal spondin-2 in placental vascular development.

Endocrinology 2019 Jan 30. Epub 2019 Jan 30.

INSERM, UMR-S 1139, Paris, France.

Placental development is particularly altered in trisomy 21 (T21) affected pregnancies. We previously described in T21-affected placentae an abnormal paracrine crosstalk between villus mesenchymal core and villus trophoblasts. T21-affected are know to be characterized by their hypovascularity. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/endo/advance-article/doi/10.1210/en
Publisher Site
http://dx.doi.org/10.1210/en.2018-00826DOI Listing
January 2019
1 Read

Minireview: TGFβ superfamily regulation of follicle-stimulating hormone synthesis by gonadotrope cells: Is there a role for bone morphogenetic proteins?

Endocrinology 2019 Feb 1. Epub 2019 Feb 1.

Department of Pharmacology and Therapeutics, Centre for Research in Reproduction and Development, McGill University, Montreal, Quebec, Canada.

Bone morphogenetic proteins (BMPs) are pleiotropic ligands in the transforming growth factor β (TGFβ) superfamily. In the early to mid-2000s, several BMPs, including BMP2, were shown to regulate follicle-stimulating hormone (FSH) synthesis alone and in synergy with activins in immortalized gonadotrope-like cell lines and primary pituitary cultures. Activins are also TGFβ family members, which were identified and named based on their abilities to selectively stimulate FSH production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-01038DOI Listing
February 2019

Development of melanocortin circuits.

Authors:
Claire Greenhill

Nat Rev Endocrinol 2019 Feb 1. Epub 2019 Feb 1.

Nature Reviews Endocrinology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41574-019-0171-0DOI Listing
February 2019

Glucose-Lowering by Leptin in the Absence of Insulin Does Not Fully Rely on the Central Melanocortin System in Male Mice.

Endocrinology 2019 Jan 29. Epub 2019 Jan 29.

Department of Cellular and Integrative Physiology, Long School of Medicine, University of Texas Health San Antonio.

Central leptin administration can ameliorate hyperglycemia in insulin-deficient rodent models independently of insulin, however, the underlying neuronal mechanism are unclear. Here, we investigate the contribution of key elements within the central melanocortin system, by examining whether central leptin injection can ameliorate hyperglycemia in total insulin-deficient mice that either lacked melanocortin 4 receptors (MC4Rs) in the whole body (MC4R KO) or selectively, in single-minded homolog 1 (SIM1)-expressing neurons (Sim1∆MC4R). We further investigated the contribution of leptin receptors (LEPRs) in agouti-related protein (AgRP)-expressing neurons (AgRP∆LEPR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00907DOI Listing
January 2019

Anxiety-induced weight loss.

Authors:
Alan Morris

Nat Rev Endocrinol 2019 Mar;15(3):130

Nature Reviews Endocrinology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41574-019-0169-7DOI Listing

GDF15 signals nutritional stress.

Authors:
Shimona Starling

Nat Rev Endocrinol 2019 Mar;15(3):130

Nature Reviews Endocrinology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41574-019-0167-9DOI Listing

The role of Dickkopf-1 in thyroid hormone-induced changes of bone remodeling in male mice.

Endocrinology 2019 Jan 25. Epub 2019 Jan 25.

Department of Medicine III, Technische Universität Dresden Medical Center, Dresden, Germany.

Background: Thyroid hormones are critical regulators of bone homeostasis, but their mechanisms of action remain incompletely understood. Exogenously induced hyper- and hypothyroidism in mice was recently found to be associated with an altered expression of the Wnt inhibitor Dickkopf-1 (Dkk1), which is a determinant of bone mass. In this study, we assessed the role of Dkk1 in thyroid hormone- induced changes in bone using conditional Dkk1 knockout mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00998DOI Listing
January 2019
1 Read

Drp1 phosphorylation is indispensable for steroidogenesis in Leydig cells.

Endocrinology 2019 Jan 25. Epub 2019 Jan 25.

Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Busan, Republic of Korea.

The initial steps of steroidogenesis occur in the mitochondria. Dynamic changes in the mitochondria are associated with their fission and fusion. Therefore, understanding the cellular and molecular relationship between steroidogenesis and mitochondrial dynamics is important. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2019-00029DOI Listing
January 2019

Circadian and ultradian variations in corticosterone level influence functioning of the male mouse basolateral amygdala.

Endocrinology 2019 Jan 22. Epub 2019 Jan 22.

Dept. Translational Neuroscience, Brain Center Rudolf Magnus, UMC Utrecht, Utrecht University, The Netherlands.

The hypothalamo-pituitary-adrenal (HPA) axis involves timed signaling between the hypothalamus, pituitary, adrenal glands and back to the brain, causing an inherently oscillating system. Corticosteroids like corticosterone (CORT) are secreted in a circadian rhythm, characterized by low and high levels respectively at the start of the inactive and active phase. The circadian rhythm overarches ultradian CORT pulses, with an approximate 1-hour interpulse intervals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00767DOI Listing
January 2019

Treating T2DM by ensuring insulin access is a global challenge.

Nat Rev Endocrinol 2019 Mar;15(3):135-137

Section on Ethnicity and Health, Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41574-019-0160-3
Publisher Site
http://dx.doi.org/10.1038/s41574-019-0160-3DOI Listing
March 2019
3 Reads

Individual response to diabetes therapy.

Authors:
Claire Greenhill

Nat Rev Endocrinol 2019 Mar;15(3):129

Nature Reviews Endocrinology, .

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41574-019-0166-x
Publisher Site
http://dx.doi.org/10.1038/s41574-019-0166-xDOI Listing
March 2019
3 Reads

Motilin: from gastric motility stimulation to hunger signalling.

Nat Rev Endocrinol 2019 Jan 23. Epub 2019 Jan 23.

Translational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.

After the discovery of motilin in 1972, motilin and the motilin receptor were studied intensely for their role in the control of gastrointestinal motility and as targets for treating hypomotility disorders. The genetic revolution - with the use of knockout models - sparked novel insights into the role of multiple peptides but contributed to a decline in interest in motilin, as this peptide and its receptor exist only as pseudogenes in rodents. The past 5 years have seen a major surge in interest in motilin, as a series of studies have shown its relevance in the control of hunger and regulation of food intake in humans in both health and disease. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41574-019-0155-0
Publisher Site
http://dx.doi.org/10.1038/s41574-019-0155-0DOI Listing
January 2019
5 Reads

Gut microbial metabolites in obesity, NAFLD and T2DM.

Nat Rev Endocrinol 2019 Jan 22. Epub 2019 Jan 22.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, Netherlands.

Evidence is accumulating that the gut microbiome is involved in the aetiology of obesity and obesity-related complications such as nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes mellitus (T2DM). The gut microbiota is able to ferment indigestible carbohydrates (for example, dietary fibre), thereby yielding important metabolites such as short-chain fatty acids and succinate. Numerous animal studies and a handful of human studies suggest a beneficial role of these metabolites in the prevention and treatment of obesity and its comorbidities. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41574-019-0156-z
Publisher Site
http://dx.doi.org/10.1038/s41574-019-0156-zDOI Listing
January 2019
13 Reads

The 'obesity paradox' in action with cancer immunotherapy.

Authors:
Joanne Lysaght

Nat Rev Endocrinol 2019 Mar;15(3):132-133

Cancer Immunology and Immunotherapy Group, Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41574-019-0161-2DOI Listing
March 2019
2 Reads

Well Students = Well Field: An Equation for Success.

Endocrinology 2019 Feb;160(2):375-376

Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2019-00012DOI Listing
February 2019

Quantitative Proteomics by SWATH-MS of Maternal Plasma Exosomes Determine Pathways Associated with Term and Preterm Birth.

Endocrinology 2019 Jan 21. Epub 2019 Jan 21.

Department of Obstetrics and Gynecology, Ochsner Baptist Hospital, New Orleans, Louisiana, USA.

Introduction: Exosomes are membrane-bound nanovesicles that transport molecular signals between cells. This study determined changes in maternal plasma exosome proteomics contents in term and preterm births.

Methods: Maternal plasma (MP) samples were collected from group 1: term not-in labor (TNIL, n=13); group 2: term in labor (TL, n= 11), group 3: preterm premature rupture of membranes (pPROM, n=8); and group 4: preterm birth (PTB, n=13). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00820DOI Listing
January 2019
2 Reads

Kisspeptin Stimulation of Prolactin Secretion Requires Kiss1 Receptor but Not in Tuberoinfundibular Dopaminergic Neurons.

Endocrinology 2019 Mar;160(3):522-533

Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Kisspeptin has been shown to stimulate prolactin secretion. We investigated whether kisspeptin acts through the Kiss1 receptor (Kiss1r) to regulate dopamine and prolactin. Initially, we evaluated prolactin response in a Kiss1r-deficient mouse line, in which Kiss1r had been knocked into GnRH neurons (Kiss1r-/-R). Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/endo/advance-article/doi/10.1210/en
Publisher Site
http://dx.doi.org/10.1210/en.2018-00932DOI Listing
March 2019
2 Reads

Loss of growth hormone gene (gh1) in zebrafish arrests folliculogenesis in females and delays spermatogenesis in males.

Endocrinology 2019 Jan 21. Epub 2019 Jan 21.

Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China.

As a master hormone controlling growth and metabolism, growth hormone (GH) is also known to regulate reproduction. Studies in mammals have shown that mutations in GH or its receptor (GHR) not only result in retardation in body growth but also reproductive dysfunctions in both sexes. However, the roles of GH in reproduction of other vertebrates are poorly defined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00878DOI Listing
January 2019

A new class of AR antagonists?

Authors:
Annette Fenner

Nat Rev Endocrinol 2019 Mar;15(3):128

Chief Editor, Nature Reviews Urology, .

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41574-019-0163-0
Publisher Site
http://dx.doi.org/10.1038/s41574-019-0163-0DOI Listing
March 2019
3 Reads
13.281 Impact Factor

Potential treatment strategy for NASH.

Authors:
Alan Morris

Nat Rev Endocrinol 2019 Mar;15(3):129

Nature Reviews Endocrinology, .

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41574-019-0162-1
Publisher Site
http://dx.doi.org/10.1038/s41574-019-0162-1DOI Listing
March 2019
3 Reads

A hyperandrogenic environment causes intrinsic defects that are detrimental to follicular dynamics in a PCOS mouse model.

Endocrinology 2019 Jan 16. Epub 2019 Jan 16.

School of Women's & Children's Health, University of New South Wales, Sydney, NSW, Australia.

Polycystic ovary syndrome (PCOS) is a common cause of infertility. Hyperandrogenism is both a major symptom and key diagnostic trait of PCOS; however, the direct impact of this androgen excess on ovarian dynamics is unclear. By combining a DHT-induced PCOS mouse model with an ex vivo follicle culture system, we investigated the impact of hyperandrogenism on ovarian function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00966DOI Listing
January 2019
3 Reads

Epithelial Mutations in Endometriosis: Link to Ovarian Cancer.

Endocrinology 2019 Jan 17. Epub 2019 Jan 17.

Division of Reproductive Medicine in Science, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University.

While epidemiologic and histopathologic associations between endometriosis and epithelial ovarian cancer have been reported, the underlying molecular and cellular mechanisms are not well understood. Recent publications suggest a possible genetic link. Driver mutations in PIK3CA, KRAS, ARID1A and other genes have been found in the epithelium of intrauterine endometrial tissue, ovarian and extraovarian pelvic endometriosis tissue, ovarian cancers associated with endometriosis (clear cell and endometrioid type) and other epithelial ovarian cancers. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/endo/advance-article/doi/10.1210/en
Publisher Site
http://dx.doi.org/10.1210/en.2018-00794DOI Listing
January 2019
6 Reads

Circadian rhythms and exercise - re-setting the clock in metabolic disease.

Nat Rev Endocrinol 2019 Jan 17. Epub 2019 Jan 17.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Perturbed diurnal rhythms are becoming increasingly evident as deleterious events in the pathology of metabolic diseases. Exercise is well characterized as a crucial intervention in the prevention and treatment of individuals with metabolic diseases. Little is known, however, regarding optimizing the timing of exercise bouts in order to maximize their health benefits. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41574-018-0150-x
Publisher Site
http://dx.doi.org/10.1038/s41574-018-0150-xDOI Listing
January 2019
10 Reads

Mechanisms of weight regain after weight loss - the role of adipose tissue.

Nat Rev Endocrinol 2019 Jan 17. Epub 2019 Jan 17.

NUTRIM School for Nutrition and Translational Research in Metabolism, Department of Human Biology, Maastricht University, Maastricht, Netherlands.

One of the biggest challenges in the management of obesity is the prevention of weight regain after successful weight loss. Weight regain after weight loss has large interindividual variation. Although many factors probably contribute to this variation, we hypothesize that variability in biological responses associated with weight loss-induced shrinking of subcutaneous adipocytes has an important role. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41574-018-0148-4
Publisher Site
http://dx.doi.org/10.1038/s41574-018-0148-4DOI Listing
January 2019
11 Reads

Drivers of islet inflammation.

Authors:
Shimona Starling

Nat Rev Endocrinol 2019 Mar;15(3):128

Nature Reviews Endocrinology, .

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41574-019-0159-9
Publisher Site
http://dx.doi.org/10.1038/s41574-019-0159-9DOI Listing
March 2019
3 Reads

A new shade of beige.

Authors:
Anna Kriebs

Nat Rev Endocrinol 2019 Mar;15(3):127

Associate Editor, Nature Communications, .

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41574-019-0157-y
Publisher Site
http://dx.doi.org/10.1038/s41574-019-0157-yDOI Listing
March 2019
3 Reads

Integrative Genomic Analysis of OCT1 Reveals Coordinated Regulation of Androgen Receptor in Advanced Prostate Cancer.

Endocrinology 2019 Feb;160(2):463-472

Department of Functional Biogerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

The ligand-dependent transcription factor androgen receptor (AR) plays a critical role in prostate cancer progression. We previously reported that Octamer transcription factor 1 (OCT1), an AR collaborative factor, facilitated the AR genomic bindings to regulate diverse programs of gene expression in AR-dependent prostate cancer cells. Repression of OCT1 binding can serve as a potential treatment strategy for advanced prostate cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-00923DOI Listing
February 2019
1 Read

Letter to the Editor: "Hysterectomy Uniquely Impacts Spatial Memory in a Rat Model: A Role for the Nonpregnant Uterus in Cognitive Processes".

Authors:
Ethan H Beckley

Endocrinology 2019 Feb;160(2):460

Department of Psychiatry, Oregon Health & Science University, Portland, Oregon.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-01060DOI Listing
February 2019
1 Read

Adipocyte GR Inhibits Healthy Adipose Expansion Through Multiple Mechanisms in Cushing Syndrome.

Endocrinology 2019 Mar 1;160(3):504-521. Epub 2019 Mar 1.

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

In Cushing syndrome, excessive glucocorticoids lead to metabolic disturbances, such as insulin resistance, adipocyte hypertrophy, and liver steatosis. In vitro experiments have highlighted the importance of adipocyte glucocorticoid receptor (GR), but its metabolic roles in vivo have not been fully elucidated in Cushing syndrome. In this study, using clinical samples from patients with Cushing syndrome and adipocyte-specific GR knockout (AGRKO) mice, we investigated the roles of adipocyte GR and its clinical relevance in Cushing syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-01029DOI Listing
March 2019
1 Read

Characterization of GnRH pulse generator activity in male mice using GCaMP fiber photometry.

Endocrinology 2019 Jan 15. Epub 2019 Jan 15.

Centre for Neuroendocrinology and Department of Physiology, University of Otago School of Biomedical Sciences, Dunedin, New Zealand.

Kisspeptin neurons located in the hypothalamic arcuate nucleus (ARN) are thought to represent the gonadotropin-releasing hormone (GnRH) pulse generator responsible for driving pulsatile luteinizing hormone (LH) secretion. The recent development of GCaMP6 fiber photometry technology has made it possible to perform long-term recordings of the population activity of the ARN kisspeptin neurons in conscious behaving mice. Using this approach, we show that ARN kisspeptin neurons in intact male mice exhibit ∼2 min-long episodes of synchronized activity that have a mean inter-episode interval of 166 min with a very wide range (43-347 min). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2018-01047DOI Listing
January 2019
1 Read