38,875 results match your criteria Endocrinology[Journal]


Regulating metabolism and ageing - the role of PI3K.

Authors:
Claire Greenhill

Nat Rev Endocrinol 2019 Apr 23. Epub 2019 Apr 23.

Nature Reviews Endocrinology, .

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http://dx.doi.org/10.1038/s41574-019-0208-4DOI Listing

Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets.

Endocrinology 2019 May;160(5):1150-1163

Division of Endocrinology, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.

Pancreatic β-cells undergo profound hyperplasia during pregnancy to maintain maternal euglycemia. Failure to reprogram β-cells into a more replicative state has been found to underlie susceptibility to gestational diabetes mellitus (GDM). We recently identified a requirement for prolactin receptor (PRLR) signaling in the metabolic adaptations to pregnancy, where β-cell-specific PRLR knockout (βPRLRKO) mice exhibit a metabolic phenotype consistent with GDM. Read More

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http://dx.doi.org/10.1210/en.2018-00991DOI Listing

Vascular Endothelial Growth Factor Delivery to Placental Basal Plate Promotes Uterine Artery Remodeling in the Primate.

Endocrinology 2019 Apr 19. Epub 2019 Apr 19.

Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland.

Extravillous trophoblast (EVT) uterine artery remodeling (UAR) promotes placental blood flow, but UAR regulation is unproven. Elevating estradiol (E2) in early baboon pregnancy suppressed UAR and EVT vascular endothelial growth factor (VEGF) expression, but this did not prove VEGF mediated this process. Therefore, our primate model of prematurely elevating E2 and contrast-enhanced ultrasound cavitation of microbubble carriers (CEU/MB) were used to deliver VEGF DNA to the placental basal plate (PBP) to establish VEGF role in UAR. Read More

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http://dx.doi.org/10.1210/en.2019-00059DOI Listing

Growth hormone induces colon DNA damage independent of IGF-1.

Endocrinology 2019 Apr 19. Epub 2019 Apr 19.

Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

DNA damage occurs as a result of environmental insults and aging, and if unrepaired, may lead to chromosomal instability and tumorigenesis. As growth hormone (GH) suppresses ATM kinase phosphorylation, decreases DNA repair, and increases DNA damage accumulation, we elucidated whether GH effects on DNA damage are mediated through induced insulin-like growth factor (IGF)-1. In non-tumorous human colon cells, GH, but not IGF-1, enhanced DNA damage. Read More

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2019-00132DOI Listing
April 2019
2 Reads

Transgenerational effects of endocrine disrupting chemicals on male and female reproduction.

Endocrinology 2019 Apr 18. Epub 2019 Apr 18.

Department of Comparative Biosciences, University of Illinois, Urbana, IL.

Endocrine disrupting chemicals are known to interfere with normal reproductive function and hormone signaling. Phthalates, bisphenol A, pesticides, and environmental contaminants such as polychlorinated biphenyls and dioxins are known endocrine disrupting chemicals that have been shown to negatively affect both male and female reproduction. Exposure to these chemicals occurs on a daily basis due to these compounds being found in plastics, personal care products, and pesticides. Read More

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2019-00034DOI Listing
April 2019
2 Reads

Chronic High-Fat Diet Exacerbates Sexually Dimorphic Pomctm1/tm1 Mouse Obesity.

Endocrinology 2019 May;160(5):1081-1096

Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Mice with a targeted mutation in the pro-opiomelanocortin (Pomc) gene (Pomctm1/tm1 mice) are unable to synthesize desacetyl-α-MSH and α-MSH and they develop obesity when fed chow diet. In this study, we hypothesized that a chronic high-fat (HF) diet exacerbates Pomctm1/tm1 mouse obesity. Male and female Pomcwt/wt and Pomctm1/tm1 mice were fed low-fat (LF) (10 kcal percent fat) or HF (45 kcal percent fat) diets from weaning for 23 weeks. Read More

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https://academic.oup.com/endo/article/160/5/1081/5371331
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http://dx.doi.org/10.1210/en.2018-00924DOI Listing
May 2019
1 Read

A new strategy for vascular complications in young people with type 1 diabetes mellitus.

Nat Rev Endocrinol 2019 Apr 17. Epub 2019 Apr 17.

Department of Paediatrics, University of Cambridge, Cambridge, UK.

Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type 1 diabetes mellitus (T1DM). Poor glycaemic control and consequent increased HbA levels are major risk factors for the development of vascular complications. HbA levels are the main focus of current management strategies; however, the recommended target is rarely achieved in adolescents. Read More

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http://www.nature.com/articles/s41574-019-0198-2
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http://dx.doi.org/10.1038/s41574-019-0198-2DOI Listing
April 2019
1 Read

CAMSAP2 is a microtubule minus-end targeting protein (-TIP) that regulates BTB dynamics through cytoskeletal organization.

Endocrinology 2019 Apr 17. Epub 2019 Apr 17.

The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, NY.

During spermatogenesis, microtubule (MT) cytoskeleton in Sertoli cells confers blood-testis barrier (BTB) function, but the regulator(s) and the mechanism(s) that modulate MT dynamics remains unexplored. Herein, we examined the role of CAMSAP2 (calmodulin-regulated spectrin-associated protein 2, a member of the CAMSAP/Patronin protein family), also a minis (-) end-targeting protein (-TIP) that binds to the minus-end (i.e. Read More

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http://dx.doi.org/10.1210/en.2018-01097DOI Listing
April 2019
4.503 Impact Factor

Obesity - no role for pro-inflammatory liver macrophages.

Authors:
Alan Morris

Nat Rev Endocrinol 2019 Apr 16. Epub 2019 Apr 16.

Nature Reviews Endocrinology, .

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http://dx.doi.org/10.1038/s41574-019-0207-5DOI Listing

Glucocorticoid Receptor-Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses.

Endocrinology 2019 May;160(5):1044-1056

Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

Mineralocorticoid and glucocorticoid receptors (MRs and GRs) constitute a functionally important dual receptor system detecting and transmitting circulating corticosteroid signals. High expression of MRs and GRs occurs in the same cells in the limbic system, the primary site of glucocorticoid action on cognition, behavior, and mood; however, modes of interaction between the receptors are poorly characterized. We used chromatin immunoprecipitation with nucleotide resolution using exonuclease digestion, unique barcode, and single ligation (ChIP-nexus) for high-resolution genome-wide characterization of MR and GR DNA binding profiles in neuroblastoma cells and demonstrate recruitment to highly similar DNA binding sites. Read More

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http://dx.doi.org/10.1210/en.2018-00819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462215PMC

Understanding lipid metabolism through hepatic steat-omics.

Nat Rev Endocrinol 2019 Apr 12. Epub 2019 Apr 12.

INSERM UMR1011, European Genomic Institute for Diabetes, University of Lille, CHU Lille, Institut Pasteur de Lille, Lille, France.

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http://dx.doi.org/10.1038/s41574-019-0203-9DOI Listing

Low IGF-I Bioavailability Impairs Growth and Glucose Metabolism in a Mouse Model of Human PAPPA2 p.Ala1033Val Mutation.

Endocrinology 2019 Apr 12. Epub 2019 Apr 12.

Cincinnati Center for Growth Disorders, Division of Endocrinology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Bioactive free insulin-like growth factor (IGF-I) is critically important for growth. The bioavailability of IGF-I is modulated by the IGF-binding proteins and their proteases, such as pregnancy-associated plasma protein-A2 (PAPP-A2). We have created a mouse model with a specific mutation in PAPPA2 identified in a human with PAPP-A2 deficiency. Read More

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http://dx.doi.org/10.1210/en.2018-00755DOI Listing
April 2019
1 Read

SCFAs - the thin microbial metabolic line between good and bad.

Authors:
Matteo Serino

Nat Rev Endocrinol 2019 Apr 11. Epub 2019 Apr 11.

IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France.

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http://dx.doi.org/10.1038/s41574-019-0205-7DOI Listing

Insulin and the insulin receptor regulate gene expression.

Authors:
Claire Greenhill

Nat Rev Endocrinol 2019 Apr 11. Epub 2019 Apr 11.

Nature Reviews Endocrinology, .

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http://dx.doi.org/10.1038/s41574-019-0206-6DOI Listing

Longevity is innate.

Authors:
Shimona Starling

Nat Rev Endocrinol 2019 Apr 9. Epub 2019 Apr 9.

Nature Reviews Endocrinology, .

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http://www.nature.com/articles/s41574-019-0202-x
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http://dx.doi.org/10.1038/s41574-019-0202-xDOI Listing
April 2019
1 Read

Grainyhead-like protein 2: The emerging role in hormone-dependent cancers and epigenetics.

Endocrinology 2019 Apr 8. Epub 2019 Apr 8.

McArdle Laboratory for Cancer Research, Department of Oncology and Carbone Comprehensive Cancer Center, University of Wisconsin - Madison, Madison, Wisconsin USA.

In mammals, the Grainyhead-like transcription factor family (GRHL) is composed of three nuclear proteins that are responsible for driving epithelial cell fate: GRHL1, GRHL2, and GRHL3. GRHL2 is important in maintaining proper tubulogenesis during development and in suppressing the epithelial to mesenchymal transition (EMT). Within the past decade, evidence indicates both tumor suppressive and oncogenic roles for GRHL2 in various types of cancers. Read More

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http://dx.doi.org/10.1210/en.2019-00213DOI Listing

Immunometabolism sentinels: Gut surface T-cells regulate GLP-1 availability.

Endocrinology 2019 Apr 8. Epub 2019 Apr 8.

Department of Biochemistry and Biomedical Sciences and Farncombe Family Digestive Health Research Institute and Centre for Metabolism, Obesity, and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2019-00215DOI Listing
April 2019
1 Read

A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice.

Endocrinology 2019 Apr 5. Epub 2019 Apr 5.

Brigham and Women's Hospital, Boston, MA, USA.

The type 2 iodothyronine-deiodinase (D2) enzyme converts T4 to T3, and mice deficient in this enzyme (D2KO mice) have decreased T3 derived from T4 in skeletal muscle despite normal circulating T3 levels. Because slow skeletal muscle is particularly susceptible to changes in T3 levels, we expected that D2 inactivation would result in more pronounced slow-muscle characteristics in the soleus muscle, mirroring hypothyroidism. However, ex vivo studies of D2KO soleus revealed higher rates of twitch contraction and relaxation, while resistance to fatigue was reduced. Read More

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http://dx.doi.org/10.1210/en.2019-00088DOI Listing
April 2019
1 Read

Phosphorylation of forkhead protein FoxO1 at Ser253 regulates glucose homeostasis in mice.

Endocrinology 2019 Apr 5. Epub 2019 Apr 5.

Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, TX, USA.

The transcription factor forkhead boxO1 (FoxO1) is a key mediator in the insulin signaling pathway and controls multiple physiological functions, including hepatic glucose production (HGP) and pancreatic β-cell function. We previously demonstrated that Ser256 in human FOXO1, equivalent to Ser253 in mouse FoxO1, is a key phosphorylation site mediating the effect of insulin as a target of Akt on suppressing FOXO1 activity and expression of target genes responsible for gluconeogenesis. Here, we investigated the role of FoxO1-Ser253 phosphorylation in control of glucose hemostasis in vivo, by generating global FoxO1-S253A/A knock-in (KI) mice, in which FoxO1-Ser253 alleles were replaced with alanine (A substitution), blocking FoxO1-S253 phosphorylation. Read More

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http://dx.doi.org/10.1210/en.2018-00853DOI Listing
April 2019
2 Reads

VCAM1 is Induced in Ovarian Theca and Stromal Cells in a Mouse Model of Androgen Excess.

Endocrinology 2019 Apr 5. Epub 2019 Apr 5.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.

Ovarian theca androgen production is regulated by the pituitary luteinizing hormone (LH) and intra-follicular factors. Enhanced androgen biosynthesis by theca cells contributes to polycystic ovary syndrome (PCOS) in women, but the ovarian consequences of elevated androgens are not completely understood. Our study documents the molecular events that are altered in the theca and stromal cells of mice exposed to high androgen levels, using the non-aromatizable androgen DHT. Read More

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http://dx.doi.org/10.1210/en.2018-00731DOI Listing
April 2019
2 Reads

Subtyping obesity.

Authors:
Alan Morris

Nat Rev Endocrinol 2019 Apr 4. Epub 2019 Apr 4.

Nature Reviews Endocrinology, .

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http://dx.doi.org/10.1038/s41574-019-0201-yDOI Listing

Improving pregnancy outcomes in women with diabetes mellitus: modern management.

Nat Rev Endocrinol 2019 Apr 4. Epub 2019 Apr 4.

Center for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.

Women with pre-existing (type 1 or type 2) diabetes mellitus are at increased risk of pregnancy complications, such as congenital malformations, preeclampsia and preterm delivery, compared with women who do not have diabetes mellitus. Approximately half of pregnancies in women with pre-existing diabetes mellitus are complicated by fetal overgrowth, which results in infants who are overweight at birth and at risk of birth trauma and, later in life, the metabolic syndrome, cardiovascular disease and type 2 diabetes mellitus. Strict glycaemic control with appropriate diet, use of insulin and, if necessary, antihypertensive treatment is the cornerstone of diabetes mellitus management to prevent pregnancy complications. Read More

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http://www.nature.com/articles/s41574-019-0197-3
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http://dx.doi.org/10.1038/s41574-019-0197-3DOI Listing
April 2019
10 Reads

TH at the heart of the matter.

Authors:
Anna Kriebs

Nat Rev Endocrinol 2019 Apr 4. Epub 2019 Apr 4.

Associate Editor Nature Communications, .

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http://dx.doi.org/10.1038/s41574-019-0200-zDOI Listing

Anticipating Future Demands: Hormone-Induced Transcriptional Programming in the Maternal Pancreas During Pregnancy.

Authors:
Sharon R Ladyman

Endocrinology 2019 May;160(5):1164-1165

Centre for Neuroendocrinology and Department of Anatomy, School of Medical Sciences, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1210/en.2019-00243DOI Listing

SFRP4 is a negative regulator of ovarian follicle development and female fertility.

Endocrinology 2019 Apr 3. Epub 2019 Apr 3.

Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada.

WNT signaling regulates a variety of ovarian processes including follicle development, granulosa cell (GC) proliferation and differentiation, steroidogenesis and ovulation. The secreted frizzled-related proteins (SFRPs) comprise a family of WNT signaling antagonists. Sfrp4 expression was previously reported to be induced in ovarian GCs and cumulus cells in vivo following hCG treatment, suggesting that it may play key roles in cumulus expansion, ovulation/luteinization and corpus luteum (CL) function. Read More

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http://dx.doi.org/10.1210/en.2019-00212DOI Listing

Response to Letter to the Editor: "Integrative Genomic Analysis of OCT1 Reveals Coordinated Regulation of Androgen Receptor in Advanced Prostate Cancer".

Endocrinology 2019 May;160(5):1066

Department of Functional Biogerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo Japan.

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http://dx.doi.org/10.1210/en.2019-00207DOI Listing
May 2019
1 Read

Increased SLC38A4 Amino Acid Transporter Expression in Human Pancreatic α-Cells After Glucagon Receptor Inhibition.

Endocrinology 2019 May;160(5):979-988

Regeneron Pharmaceuticals, Inc., Tarrytown, New York.

Plasma amino acids and their transporters constitute an important part of the feedback loop between the liver and pancreatic α-cell function, and glucagon regulates hepatic amino acid turnover. Disruption of hepatic glucagon receptor action activates the loop and results in high plasma amino acids and hypersecretion of glucagon associated with α-cell hyperplasia. In the present study, we report a technique to rescue implanted human pancreatic islets from the mouse kidney capsule. Read More

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http://dx.doi.org/10.1210/en.2019-00022DOI Listing

Author Correction: Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine.

Nat Rev Endocrinol 2019 May;15(5):312

Peking University Diabetes Center, Director of Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.

In the version of this article published online and in print, there was a mistake in the legend of Fig. 2 regarding the descriptions of the red and blue colours in the Figure. The text should have read 'The blue and red colours represent regions (provinces) with wheat and rice as the staple food, respectively. Read More

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http://dx.doi.org/10.1038/s41574-019-0199-1DOI Listing
May 2019
1 Read

Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model.

Endocrinology 2019 Mar 29. Epub 2019 Mar 29.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting approximately 10-15% of reproductive-aged women worldwide. Diagnosis requires two of the following: hyperandrogenism, oligo/anovulation and polycystic ovaries. In addition to reproductive dysfunction, many women with PCOS display metabolic abnormalities associated with hyperandrogenism. Read More

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2019-00050DOI Listing
March 2019
13 Reads

Neonatal estrogen causes irreversible male infertility via specific suppressive action on hypothalamic Kiss1 neurons.

Endocrinology 2019 Mar 28. Epub 2019 Mar 28.

Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.

Aberrant exposure to estrogen-like compounds during the critical developmental period may cause improper hypothalamic programming, thus resulting in reproductive dysfunction in adulthood in male mammals. Kisspeptin-neurokinin B (NKB)-dynorphin A (Dyn) (KNDy) neurons in the arcuate nucleus (ARC) have been suggested to govern tonic gonadotropin-releasing hormone (GnRH)/gonadotropin release to control reproduction in male mammals. Here we report that chronic exposure to supra-physiological levels of estrogen during the neonatal period caused an irreversible suppression of KNDy genes in the ARC, resulting in reproductive dysfunction in male rats. Read More

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http://dx.doi.org/10.1210/en.2018-00732DOI Listing
March 2019
1 Read

Letter to the Editor: "Integrative Genomic Analysis of OCT1 Reveals Coordinated Regulation of Androgen Receptor in Advanced Prostate Cancer".

Endocrinology 2019 May;160(5):1065

Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.

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http://dx.doi.org/10.1210/en.2019-00138DOI Listing
May 2019
4.503 Impact Factor

Metabolism of 13C-labeled fatty acids in term human placental explants by liquid chromatography mass spectrometry.

Endocrinology 2019 Mar 28. Epub 2019 Mar 28.

Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Placental lipid transport and metabolism is poorly understood despite its importance for fetal development and life-long health. We aimed to explore fatty acid (FA) processing in human villous placental explants from seven uncomplicated term singleton pregnancies delivered by elective cesarean section. Explants were treated with stable-isotope labeled palmitic acid (13C-PA), oleic acid (13C-OA) or docosahexaenoic acid (13C-DHA) for 3, 24 or 48 hours. Read More

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http://dx.doi.org/10.1210/en.2018-01020DOI Listing
March 2019
1 Read

Attenuated Dentin Matrix Protein 1 Enhances Fibroblast Growth Factor 23 in Calvaria in Primary Hyperparathyroidism Model.

Endocrinology 2019 Mar 27. Epub 2019 Mar 27.

Osaka City University Graduate School of Medicine, Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka, Japan.

Fibroblast growth factor 23 (FGF23) secretion is facilitated by parathyroid hormone (PTH), particularly in hyperparathyroidism. PTH also attenuates dentin matrix protein 1 (DMP1), which is produced by osteocytes to contribute to bone mineralization and suppress FGF23 expression. Nevertheless, it remains unknown whether attenuated DMP1 affects FGF23 expression in hyperparathyroidism. Read More

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http://dx.doi.org/10.1210/en.2019-00017DOI Listing

Physiological and Pathological Androgen Actions in the Ovary.

Endocrinology 2019 Mar 26. Epub 2019 Mar 26.

Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.

Androgens, while traditionally though to be male sex steroids, play important roles in female reproduction, both in healthy and pathological states. This minireview focuses on recent advances in our knowledge of the role of androgens in the ovary. Androgen receptor (AR) is expressed in oocytes, granulosa cells and theca cells, and is temporally regulated during follicular development. Read More

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http://dx.doi.org/10.1210/en.2019-00101DOI Listing
March 2019
1 Read

Identification of leptin receptor-expressing cells in the nodose ganglion of male mice.

Endocrinology 2019 Mar 25. Epub 2019 Mar 25.

Division of Hypothalamic Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390.

Leptin has been proposed to modulate viscerosensory information directly at the level of vagal afferents. In support of this view, broad expression for the leptin receptor (Lepr) has previously been reported in vagal afferents. However, the exact identity and distribution of leptin-sensitive vagal afferents has not been elucidated. Read More

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http://dx.doi.org/10.1210/en.2019-00021DOI Listing

The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure.

Endocrinology 2019 Mar 25. Epub 2019 Mar 25.

ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.

Transfer RNAs (tRNAs) are crucial non-coding RNA molecules that serve as aminoacid carriers during protein synthesis. The transcription of tRNA genes is a highly regulated process. The tRNA pool is tissue- and cell- specific, it varies during development, and is modulated by the environment. Read More

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http://dx.doi.org/10.1210/en.2019-00098DOI Listing
March 2019
1 Read

Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus.

Endocrinology 2019 Mar 22. Epub 2019 Mar 22.

Centre for Neuroendocrinology and Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

Hyperprolactinemia causes infertility, but the specific mechanism is unknown. It is clear that elevated prolactin levels suppress pulsatile release of gonadotrophin-releasing hormone (GnRH) from the hypothalamus, with a consequent reduction in pulsatile luteinizing hormone (LH) secretion from the pituitary. Only a few GnRH neurons express prolactin receptors (Prlr), however, and thus prolactin must act indirectly in the underlying neural circuitry. Read More

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http://dx.doi.org/10.1210/en.2019-00038DOI Listing
March 2019
1 Read

Phospho-PR Isoforms and Cancer Stem Cells: What Does the FOXO1 Say?

Endocrinology 2019 May;160(5):1067-1068

Department of Pathology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2019-00158DOI Listing
May 2019
8 Reads

The effect of the Chinese Famine on type 2 diabetes mellitus epidemics.

Nat Rev Endocrinol 2019 Mar 21. Epub 2019 Mar 21.

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.

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http://www.nature.com/articles/s41574-019-0195-5
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http://dx.doi.org/10.1038/s41574-019-0195-5DOI Listing
March 2019
11 Reads

Prolactin - a pleiotropic factor in health and disease.

Nat Rev Endocrinol 2019 Mar 21. Epub 2019 Mar 21.

Inserm U1185, Faculté de Médecine Paris Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France.

The principal role of prolactin in mammals is the regulation of lactation. Prolactin is a hormone that is mainly synthesized and secreted by lactotroph cells in the anterior pituitary gland. Prolactin signalling occurs via a unique transmembrane prolactin receptor (PRL-R). Read More

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http://dx.doi.org/10.1038/s41574-019-0194-6DOI Listing
March 2019
1 Read

Chronic Exposure of Mice to Bisphenol-A Alters Uterine FGF Signaling and Leads to Aberrant Epithelial Proliferation.

Endocrinology 2019 Mar 20. Epub 2019 Mar 20.

Department of Molecular and Integrative Physiology, University of Illinois, Urbana-Champaign, Urbana, IL.

Uterine epithelial proliferation is regulated in a paracrine manner by a complex interplay between estrogen (E) and progesterone (P) signaling, wherein E stimulates proliferation and P inhibits it. Perturbation of steroid hormone signaling within the uterine milieu could contribute to the development of endometrial hyperplasia and cancer. It is well established that bisphenol-A (BPA) is an endocrine disrupting chemical with weak estrogenic effects, although little is known about how it impacts steroid hormone signaling in the adult uterus. Read More

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http://dx.doi.org/10.1210/en.2018-00872DOI Listing
March 2019
1 Read

Carbohydrate quality is key for a healthy and sustainable diet.

Nat Rev Endocrinol 2019 May;15(5):257-258

Diabetes, Nutrition and Metabolism research group, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.

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http://dx.doi.org/10.1038/s41574-019-0190-xDOI Listing

Interactions Between the Gravitostat and the Fibroblast Growth Factor System for the Regulation of Body Weight.

Endocrinology 2019 May;160(5):1057-1064

Centre for Bone and Arthritis Research, Department of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Both fibroblast growth factors (FGFs), by binding to FGF receptors (FGFRs), and activation of the gravitostat, by artificial loading, decrease the body weight (BW). Previous studies demonstrate that both the FGF system and loading have the capacity to regulate BW independently of leptin. The aim of the current study was to determine the possible interactions between the effect of increased loading and the FGF system for the regulation of BW. Read More

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http://dx.doi.org/10.1210/en.2018-01002DOI Listing
May 2019
3 Reads

Genesis, genes and epigenetics of endometriosis-associated infertility.

Authors:
Sun-Wei Guo

Nat Rev Endocrinol 2019 May;15(5):259-260

Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1038/s41574-019-0191-9DOI Listing
May 2019
1 Read

Neuronal clock coordinates appetite.

Authors:
Shimona Starling

Nat Rev Endocrinol 2019 May;15(5):253

Nature Reviews Endocrinology, .

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http://dx.doi.org/10.1038/s41574-019-0196-4DOI Listing
May 2019
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The role of thyroglobulin in thyroid hormonogenesis.

Nat Rev Endocrinol 2019 Mar 18. Epub 2019 Mar 18.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical School, Ann Arbor, MI, USA.

In humans, the thyroid hormones T and T are synthesized in the thyroid gland in a process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of thyroglobulin is conserved in all vertebrates. Upon thyroglobulin delivery from thyrocytes to the follicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become iodinated to form mono-iodotyrosine (MIT) and/or di-iodotyrosine (DIT); however, selective tyrosine residues lead to preferential formation of T and T at distinct sites. Read More

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http://dx.doi.org/10.1038/s41574-019-0184-8DOI Listing
March 2019
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MST Kinases and Metabolism.

Endocrinology 2019 May;160(5):1111-1118

Departamento de Fisioloxía and Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CiMUS), Instituto de Investigación Sanitaria de Santiago (IDIS), Universidade de Santiago de Compostela, A Coruña, Spain.

Since the discovery of the mammalian sterile twenty (MST) kinase family of proteins (MST1/STK4, MST2/STK3, MST3/STK24, and SOK1/STK25), much has been done that adds to our knowledge of their structure, regulation, and function. In the last few years, a series of articles has unveiled a previous unknown relation of these kinases with metabolic regulation and the homeostasis of metabolic tissues. The aim of this review is to bring together this body of data to provide a detailed picture of the current knowledge about these proteins, metabolism, and some of the associated diseases. Read More

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http://dx.doi.org/10.1210/en.2018-00898DOI Listing

Ghrelin's relationship to blood glucose.

Endocrinology 2019 Mar 15. Epub 2019 Mar 15.

Divisions of Hypothalamic Research and Endocrinology & Metabolism, Department of Internal Medicine and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX.

Much effort has been directed at studying the orexigenic actions of administered ghrelin and the potential effects of the endogenous ghrelin system on food intake, food reward, body weight, adiposity, and energy expenditure. Although endogenous ghrelin's actions on some of these processes remain ambiguous, its glucoregulatory actions have emerged as well-recognized features during extreme metabolic conditions. The blood glucose-raising actions of ghrelin are beneficial during starvation-like conditions, defending against life-threatening falls in blood glucose, but are seemingly detrimental in obese states and in certain monogenic forms of diabetes, contributing to hyperglycemia. Read More

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http://dx.doi.org/10.1210/en.2019-00074DOI Listing
March 2019
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The Activin Social Network: Activin, Inhibin, and Follistatin in Breast Development and Cancer.

Endocrinology 2019 May;160(5):1097-1110

Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio.

Activins and inhibins are closely related protein heterodimers with a similar tissue distribution; however, these two complexes have opposing functions in development and disease. Both are secreted cytokine hormones, with activin the primary inducer of downstream signaling cascades and inhibin acting as a rheostat that exquisitely governs activin function. Adding to the complexity of activin signaling, follistatin, a highly glycosylated monomeric protein, binds activin with high affinity and restrains downstream pathway activation but through a mechanism distinct from that of inhibin. Read More

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2019-00015DOI Listing
May 2019
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