38,719 results match your criteria Endocrinology[Journal]


Relieving ER stress to target NASH-driven hepatocellular carcinoma.

Nat Rev Endocrinol 2018 Dec 14. Epub 2018 Dec 14.

Division of Diabetes & Metabolism, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

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December 2018

Calreticulin regulates syncytialization through control of the synthesis and transportation of E-cadherin in BeWo cells.

Endocrinology 2018 Dec 14. Epub 2018 Dec 14.

Department of Obstetrics and Gynecology, Wakayama Medical University.

During placental development, mononuclear cytotrophoblasts differentiate and fuse to syncytiotrophoblasts (STB) to form syncytia, which secrete human chorionic gonadotropin (hCG). Decreased maternal perfusion of the placenta, which leads to placental dysfunction, induces changes in trophoblast syncytialization. Our previous study showed that calreticulin (CRT), a Ca2+-binding molecular chaperone found in the endoplasmic reticulum, is expressed in the human placenta and is involved in regulating extravillous trophoblast invasion, although its role in villous trophoblasts remains unclear. Read More

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December 2018

New Year's Resolutions-New Year Reviewers-New Year of Review.

Endocrinology 2019 Jan;160(1):36-37

Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois.

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January 2019

Somatostatin-somatostatin receptor 2 signaling mediates LH pulse suppression in lactating rats.

Endocrinology 2018 Dec 13. Epub 2018 Dec 13.

Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.

Follicular development and ovulation are profoundly suppressed during lactation in mammals. This suppression is suggested to be mainly due to the suckling-induced inhibition of kisspeptin gene (Kiss1) expression in the arcuate nucleus (ARC), and consequent inhibition of pulsatile gonadotropin releasing hormone (GnRH)/luteinizing hormone (LH) release. The present study aims to examine whether central somatostatin (SST) signaling mediates the suckling-induced suppression of pulsatile LH secretion. Read More

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December 2018

Sex differences in inflammatory responses to adipose tissue lipolysis in diet-induced obesity.

Endocrinology 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics and Communicable Disease, University of Michigan Medical School, Ann Arbor, MI.

Males are known to have profound adipose tissue macrophage (ATM) accumulation in gonadal white adipose tissue (GWAT) during obesity, while females are protected from such an inflammatory response even with increased adiposity. The inflammatory tone in males is linked to insulin resistance and might be the underlying cause for sex differences in metabolic disease. Factors regulating the meta-inflammatory response remain unclear but enhanced lipid storage in females may explain the reduced inflammatory response to high fat diets. Read More

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December 2018

Circadian protein affects mTORC1 activity.

Authors:
Claire Greenhill

Nat Rev Endocrinol 2018 Dec 12. Epub 2018 Dec 12.

Nature Reviews Endocrinology, .

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December 2018

Lateral hypothalamic Mc3R-expressing neurons modulate locomotor activity, energy expenditure and adiposity in male mice.

Endocrinology 2018 Dec 11. Epub 2018 Dec 11.

Dept. of Pediatrics, Division of Endocrinology, Michigan Medicine, Ann Arbor, MI.

The central melanocortin (Mc) system plays a crucial role in the control of energy balance. While the decreased energy expenditure and increased adiposity of Mc-3 receptor (Mc3R)-null mice suggest the importance of Mc3R-regulated neurons in energy homeostasis, the roles for specific subsets of Mc3R neurons in energy balance have yet to be determined. Because the lateral hypothalamic area (LHA) contributes to the control of energy expenditure and feeding, we generated Mc3rcre mice to determine the roles of LHA Mc3R (Mc3RLHA) neurons in energy homeostasis. Read More

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December 2018
1 Read

Hysterectomy Uniquely Impacts Spatial Memory in a Rat Model: A Role for the Nonpregnant Uterus in Cognitive Processes.

Endocrinology 2019 Jan;160(1):1-19

Department of Psychology, Arizona State University, Tempe, Arizona.

Approximately one-third of women experience hysterectomy, or the surgical removal of the uterus, by 60 years of age, with most surgeries occurring prior to the onset of natural menopause. The ovaries are retained in about half of these surgeries, whereas for the other half hysterectomy occurs concurrently with oophorectomy. The dogma is that the nonpregnant uterus is dormant. Read More

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January 2019

A potential role for GSK3beta in glucose-driven intrauterine catch-up growth in maternal obesity.

Endocrinology 2018 Dec 10. Epub 2018 Dec 10.

Department of Paediatrics and Adolescent Medicine, University Hospital of Cologne, Cologne, Germany.

Obesity and an unhealthy nutrition are on the rise and affect also women in childbearing age and hence, during pregnancy. Despite normal or even high birth weight the offspring suffers from long term metabolic risks. We hypothesized that fetal growth is disturbed during different intrauterine phases. Read More

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December 2018

Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice.

Endocrinology 2018 Dec 6. Epub 2018 Dec 6.

Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, CA.

As an acidic cellular microenvironment is engendered by inflammation and may determine cell differentiation, we elucidated the impact of acidic conditions on induction of POMC expression. Here, we demonstrate mechanisms for proton-sensitivity of corticotropin releasing hormone receptor 1 (CRHR1) signaling to POMC and adrenocorticotropin (ACTH) production. Low pH (6. Read More

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December 2018

ANT2 mediates hypoxia and inflammation in obesity.

Authors:
Isobel Leake

Nat Rev Endocrinol 2018 Dec 10. Epub 2018 Dec 10.

Nature Reviews Endocrinology, .

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December 2018

Skin autofluorescence predicts T2DM.

Authors:
Anna Kriebs

Nat Rev Endocrinol 2018 Dec 10. Epub 2018 Dec 10.

Associate Editor, Nature Communications, .

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December 2018
1 Read

Circadian clocks and insulin resistance.

Nat Rev Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a major cause of morbidity and mortality. The circadian timing system consists of a central brain clock in the hypothalamic suprachiasmatic nucleus and various peripheral tissue clocks. The circadian timing system is responsible for the coordination of many daily processes, including the daily rhythm in human glucose metabolism. Read More

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December 2018
1 Read

Melatonin in type 2 diabetes mellitus and obesity.

Nat Rev Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Inserm, U1016, Institut Cochin, Paris, France.

Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus (T2DM) remain two major challenges for public health systems globally. In the past 9 years, genome-wide association studies (GWAS) have established a major role for genetic variation within the MTNR1B locus in regulating fasting plasma levels of glucose and in affecting the risk of T2DM. This discovery generated a major interest in the melatonergic system, in particular the melatonin MT receptor (which is encoded by MTNR1B). Read More

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December 2018
1 Read

Highlights from SfE BES 2018.

Authors:
Claire Greenhill

Nat Rev Endocrinol 2018 Dec 5. Epub 2018 Dec 5.

Nature Reviews Endocrinology, .

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December 2018

Modelling the endocrine pancreas in health and disease.

Nat Rev Endocrinol 2018 Nov 30. Epub 2018 Nov 30.

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany.

Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss or dysfunction of pancreatic β-cells, but the pathomechanisms underlying β-cell failure in type 1 diabetes mellitus and type 2 diabetes mellitus are still poorly defined. Regeneration of β-cell mass from residual islet cells or replacement by β-like cells derived from stem cells holds great promise to stop or reverse disease progression. Read More

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November 2018
1 Read

Hepatic HKDC1 expression contributes to liver metabolism.

Endocrinology 2018 Dec 3. Epub 2018 Dec 3.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL.

Glucokinase (GCK) is the principal hexokinase (HK) in the liver, operating as a glucose sensor to regulate glucose metabolism and lipid homeostasis. Recently, we proposed Hexokinase Domain Containing-1 (HKDC1) to be a novel 5th HK with expression in the liver. Here, we reveal HKDC1 to have low glucose-phosphorylating ability and demonstrate its association with the mitochondria in hepatocytes. Read More

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December 2018
3 Reads

GnRH - a key regulator of FSH.

Endocrinology 2018 Dec 4. Epub 2018 Dec 4.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School.

The hypothalamic decapeptide, GnRH, is the gatekeeper of mammalian reproductive development and function. Activation of specific, high affinity cell surface receptors (GnRHR) on gonadotropes by GnRH triggers signal transduction cascades to stimulate the coordinated synthesis and secretion of the pituitary gonadotropins, FSH and LH. These hormones direct gonadal steroidogenesis and gametogenesis, making their tightly regulated production and secretion essential for normal sexual maturation and reproductive health. Read More

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December 2018
2 Reads

Impact of genes and environment on obesity and cardiovascular disease.

Endocrinology 2018 Dec 3. Epub 2018 Dec 3.

Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.

Obesity and abdominal obesity have been closely related to cardiovascular outcomes, and recent evidence has indicated that environmental and genetic factors act in concert in determining the risks of these conditions. Improving adherence to healthy lifestyle habits and healthy dietary patterns can at least partly counteract genetic variations related risks of obesity and cardiovascular disease (CVD). Other factors, such as epigenetic alterations, may also modulate a relationship between genetic susceptibility and these disorders. Read More

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December 2018
2 Reads

Training your brain can improve food choice.

Authors:
Alan Morris

Nat Rev Endocrinol 2018 Dec 4. Epub 2018 Dec 4.

Nature Reviews Endocrinology, .

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December 2018

Bisphenol A alters Bmal1, Per2 and Rev-Erba mRNA and requires Bmal1 to increase neuropeptide Y expression in hypothalamic neurons.

Endocrinology 2018 Nov 30. Epub 2018 Nov 30.

Department of Physiology, University of Toronto, Toronto, ON, Canada.

Bisphenol A (BPA), a ubiquitous, environmental endocrine disruptor, is considered an obesogen. Its role in the hypothalamic control of energy balance, however, remains largely unexplored. As disruption of the circadian clock is tightly associated with metabolic consequences, we explored how BPA affects the components of the molecular circadian clock in the feeding-related neurons of the hypothalamus. Read More

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November 2018
5 Reads

A Role for the Wandering Uterus?

Authors:
Nanette Santoro

Endocrinology 2018 Nov 28. Epub 2018 Nov 28.

Professor and E Stewart Taylor Chair of Obstetrics and Gynecology University of Colorado School of Medicine, Aurora, Colorado.

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November 2018

Genetically inherited - and high fat diet induced - obesity differentially alters spermatogenesis in adult male rats.

Endocrinology 2018 Nov 28. Epub 2018 Nov 28.

Department of Neuroendocrinology, National Institute for Research in Reproductive Health (ICMR), Parel, Mumbai, India.

Obesity is a multifactorial disorder with predominantly genetic and/or environmental causes. Thus, our aim was to delineate effects of genetically inherited and high fat diet induced obesity on fertility and spermatogenesis using two Wistar rat models: genetically inherited obese (GIO): WNIN/Ob and diet induced obese (DIO): High fat diet. The terminal body weights were similar in both GIO and DIO groups, but, there was a significant difference in metabolic and hormone profile between the two groups. Read More

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November 2018
4 Reads

A Carboxy-Terminal Monoleucine-Based Motif Participates in the Basolateral Targeting of the Na+/I- Symporter (NIS).

Endocrinology 2018 Nov 28. Epub 2018 Nov 28.

Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

The Na+/I- symporter (NIS), a glycoprotein expressed at the basolateral plasma membrane of thyroid follicular cells, mediates I- accumulation for thyroid hormonogenesis, and radioiodide therapy for differentiated thyroid carcinoma. However, differentiated thyroid tumors often exhibit lower I- transport than normal thyroid tissue (or even undetectable I- transport). Paradoxically, the majority of differentiated thyroid cancers show intracellular NIS expression, suggesting abnormal targeting to the plasma membrane. Read More

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November 2018
4 Reads

BAT is involved in control of satiation.

Authors:
Rebecca Kelsey

Nat Rev Endocrinol 2018 Dec;15(1)

Nature Reviews Endocrinology, .

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December 2018

Rhythms found in skin.

Authors:
Alan Morris

Nat Rev Endocrinol 2018 Dec;15(1)

Nature Reviews Endocrinology, .

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December 2018

Class II PI3K α and β are required for Rho-dependent uterine smooth muscle contraction and parturition in mice.

Endocrinology 2018 Nov 21. Epub 2018 Nov 21.

Department of Physiology, Kanazawa University School of Medicine, Kanazawa, Japan.

Class II phosphoinositide 3-kinases (PI3K), PI3K-C2α and PI3K-C2β, are highly homologous and distinct from class I and III PI3K in the catalytic products and domain structures. In contrast to class I and class III PI3Ks, physiological roles of PI3K-C2α and PI3K-C2β are not fully understood. Because we previously demonstrated that PI3K-C2α is involved in vascular smooth muscle contraction, we studied the phenotypes of smooth muscle-specific knockout (KO) mice of PI3K-C2α and PI3K-C2β. Read More

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November 2018
5 Reads

Intermittent Fasting Improves Glucose Tolerance and Promotes Adipose Tissue Remodeling in Male Mice Fed a High Fat Diet.

Endocrinology 2018 Nov 21. Epub 2018 Nov 21.

Centre for Nutrition and Gastrointestinal Disease, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

Obesity is associated with increased macrophage and extracellular matrix accumulation in adipose tissue, which can be partially reversed following weight loss by daily caloric restriction. This study examined the effects of 8 weeks of intermittent fasting (IF, 24-hours fast on 3 non-consecutive days per week) in mice fed a chow or high-fat diet (HFD, 43% fat), on markers of adipose tissue inflammation and fibrosis. We found that IF decreased energy intake, body weight and fat cell size in HFD fed mice, and decreased fat mass and improved glucose tolerance in chow and HFD fed mice. Read More

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November 2018

Free fatty acids clog up cytotoxic machinery.

Authors:
Anna Kriebs

Nat Rev Endocrinol 2018 Dec;15(1)

Associate Editor, Nature Communications, .

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December 2018
3 Reads

Inter-tissue communication in cancer cachexia.

Nat Rev Endocrinol 2018 Dec;15(1):9-20

Cancer Research Group, Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.

Cachexia is a systemic condition that occurs during many neoplastic diseases, such as cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by adipose tissue wasting and systemic inflammation. Cancer cachexia is often associated with anorexia and increased energy expenditure. Read More

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December 2018
3 Reads

Adipocyte-specific GH receptor null (AdGHRKO) mice have enhanced insulin sensitivity with reduced liver triglycerides.

Endocrinology 2018 Nov 19. Epub 2018 Nov 19.

Edison Biotechnology Institute, Ohio University, Athens, Ohio.

Global GH receptor null or "knockout" (GHRKO) mice have been extensively studied due to their unique phenotype (dwarf and obese but remarkably insulin sensitive and long-lived). To better understand the influence of adipose tissue (AT) on the GHRKO phenotype, we previously generated Fat-specific GHRKO (FaGHRKO) mice using the aP2 promoter driving Cre expression. Unlike global GHRKO mice, FaGHRKO mice are larger than control mice and have an increase in white AT (WAT) mass and adipocyte size as well as an increase in brown AT (BAT) mass. Read More

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November 2018
2 Reads

Suppression of prolactin secretion partially explains the anti-diabetic effect of bromocriptine in ob/ob mice.

Endocrinology 2018 Nov 20. Epub 2018 Nov 20.

Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

Previous studies have shown that bromocriptine mesylate (Bromo) lowers blood glucose levels in adults with type 2 diabetes mellitus. However, the mechanism of action of the anti-diabetic effects of Bromo is unclear. As a dopamine receptor agonist, Bromo can alter brain dopamine activity affecting glucose control. Read More

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November 2018
5 Reads

The obese adipose tissue microenvironment in cancer development and progression.

Nat Rev Endocrinol 2018 Nov 20. Epub 2018 Nov 20.

Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

Obesity is associated with both increased cancer incidence and progression in multiple tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These associations are driven, in part, by metabolic and inflammatory changes in adipose tissue that disrupt physiological homeostasis both within local tissues and systemically. However, the mechanisms underlying the obesity-cancer relationship are poorly understood. Read More

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November 2018
3 Reads

The Voyage Out: Endocrine Discoveries.

Endocrinology 2018 Dec;159(12):3908-3909

Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois.

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December 2018

Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases.

Nat Rev Endocrinol 2018 Nov 16. Epub 2018 Nov 16.

Institute for Diabetes and Regeneration, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

Obesity and its comorbidities, such as type 2 diabetes mellitus and cardiovascular disease, constitute growing challenges for public health and economies globally. The available treatment options for these metabolic disorders cannot reverse the disease in most individuals and have not substantially reduced disease prevalence, which underscores the unmet need for more efficacious interventions. Neurobiological resilience to energy homeostatic perturbations, combined with the heterogeneous pathophysiology of human metabolic disorders, has limited the sustainability and efficacy of current pharmacological options. Read More

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November 2018
5 Reads

Early childhood - a critical period for obesity prevention.

Nat Rev Endocrinol 2018 Dec;15(1):5-6

Institute of Endocrinology, Sydney Children's Hospitals Network, Westmead, Sydney, Australia.

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December 2018

PEPCK1 antisense oligonucleotide prevents adiposity and impairs hepatic glycogen synthesis in high-fat male fed rats.

Endocrinology 2018 Nov 15. Epub 2018 Nov 15.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

The increase in hepatic gluconeogenesis in type 2 diabetes mellitus (T2DM) is often ascribed to increased transcription of phosphoenolpyruvate carboxykinase 1 (cytosolic form, PEPCK1) though increasing evidence questions this attribution. To assess the metabolic role of PEPCK1, we treated regular chow (RC) fed and high-fat fed (HFF) male Sprague-Dawley rats with a 2'-O-methoxyethyl chimeric antisense oligonucleotide (ASO) against PEPCK1 and compared them to control ASO treated rats. PEPCK1 ASO effectively decreased PEPCK1 expression in liver and white adipose tissue (WAT). Read More

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November 2018
2 Reads

The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.

Nat Rev Endocrinol 2018 Dec;15(1):33-51

Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

The Ca-sensing receptor (CaSR) is a dimeric family C G protein-coupled receptor that is expressed in calcitropic tissues such as the parathyroid glands and the kidneys and signals via G proteins and β-arrestin. The CaSR has a pivotal role in bone and mineral metabolism, as it regulates parathyroid hormone secretion, urinary Ca excretion, skeletal development and lactation. The importance of the CaSR for these calcitropic processes is highlighted by loss-of-function and gain-of-function CaSR mutations that cause familial hypocalciuric hypercalcaemia and autosomal dominant hypocalcaemia, respectively, and also by the fact that alterations in parathyroid CaSR expression contribute to the pathogenesis of primary and secondary hyperparathyroidism. Read More

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December 2018
6 Reads

Effects of metformin mediated by gut microbiota.

Authors:
Claire Greenhill

Nat Rev Endocrinol 2018 Dec;15(1)

Nature Reviews Endocrinology, .

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December 2018

New pathways in development of liver cancer.

Authors:
Claire Greenhill

Nat Rev Endocrinol 2018 Dec;15(1)

Nature Reviews Endocrinology, .

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December 2018

Microbiota drives sex-specific differences.

Authors:
Alan Morris

Nat Rev Endocrinol 2018 Dec;15(1)

Nature Reviews Endocrinology, .

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December 2018

ER Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS.

Endocrinology 2018 Nov 12. Epub 2018 Nov 12.

Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo, Tokyo, Japan.

Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism and growth arrest of antral follicles. Previously, we found that endoplasmic reticulum (ER) stress is activated in granulosa cells of antral follicles in PCOS, evidenced by activation of unfolded protein response (UPR) genes. Based on this observation, we hypothesized that ER stress is activated by androgens in granulosa cells of antral follicles, and that activated ER stress promotes apoptosis via induction of the UPR transcription factor C/EBP homologous protein (CHOP) and subsequent activation of death receptor (DR) 5. Read More

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November 2018
6 Reads

Hormone production by human first-trimester gonads in a functional in vitro system.

Endocrinology 2018 Nov 9. Epub 2018 Nov 9.

NORDFERTIL Research Lab Stockholm, Karolinska Institutet and University Hospital, Stockholm, Sweden.

In the past, explant tissue-culture methodologies have been used to grow gonads and study their development. Results from in vitro cultures of human gonads showed limited progress towards gonadal cell differentiation and were focused mainly on germ-cell differentiation. Thus, detailed studies focusing on human first-trimester gonadal tissue functionality in vitro are still missing. Read More

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November 2018
3 Reads

Bitter taste receptor ligand improves metabolic and reproductive functions in a murine model of PCOS.

Endocrinology 2018 Nov 9. Epub 2018 Nov 9.

Johns Hopkins University School of Medicine, Department of Pediatrics, Division of Endocrinology, Baltimore, MD.

Polycystic ovary syndrome (PCOS) results from functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Cultured theca cells from polycystic ovaries of women with the most common form of PCOS overexpress most androgen producing enzymes, particularly CYP450c17. This study used a murine model of PCOS induced by chronic feeding with high fat content diet that exhibits the reproductive, hyperandrogenic, and metabolic constellation of symptoms of PCOS seen in women. Read More

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November 2018
6 Reads

17-β estradiol and 17α-ethinyl estradiol exhibit immunologic and epigenetic regulatory effects in NZB/WF1 female mice.

Endocrinology 2018 Nov 9. Epub 2018 Nov 9.

Infectious Disease Research Facility (IDRF), Department of Biomedical Sciences and Pathobiology, VA-MD College of Vet. Medicine, Virginia Tech, Blacksburg, VA.

17α-ethinyl estradiol (EE), a synthetic analog of natural estrogen 17-β estradiol (E2), is extensively used in hormonal contraceptives and estrogen replacement therapy, and has also been found in sewage effluents. Given that E2 is a well-known immunomodulator, surprisingly there has been only limited information on the cellular and molecular immunologic consequences of exposure to EE. To address this fundamental gap, we directly compared the effects of EE with E2 on splenic leukocytes of NZB/WF1 mice during the pre-autoimmune period. Read More

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November 2018
4 Reads

Microbial metabolite linked to T2DM.

Authors:
Alan Morris

Nat Rev Endocrinol 2018 Dec;15(1)

Nature Reviews Endocrinology, .

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December 2018

Fat-1 Transgene Is Associated With Improved Reproductive Outcomes.

Endocrinology 2018 Dec;159(12):3981-3992

Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, Colorado.

High intake of ω-3 polyunsaturated fatty acids (PUFAs) has been associated with a variety of health benefits. However, the role of ω-3 PUFAs in female reproductive function is unclear, with studies showing both positive and negative effects. The type of diet that ω-3 fatty acids are consumed with, for example, a balanced diet vs a high-fat diet (HFD), may influence how ω-3 fatty acids affect female reproductive function. Read More

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December 2018
12 Reads

Ca2+ Channels in Anterior Pituitary Somatotrophs: A Therapeutic Perspective.

Endocrinology 2018 Dec;159(12):4043-4055

Department of Medical Neurobiology, Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University Faculty of Medicine, Jerusalem, Israel.

Ca2+ influx through voltage-gated Ca2+ channels (VGCCs) plays a key role in GH secretion. In this review, we summarize the current state of knowledge regarding the physiology and molecular machinery of VGCCs in pituitary somatotrophs. We next discuss the possible involvement of Ca2+ channelopathies in pituitary disease and the potential use of Ca2+ channel blockers to treat pituitary disease. Read More

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December 2018
3 Reads

FSH Actions and Pregnancy: Looking Beyond Ovarian FSH Receptors.

Endocrinology 2018 Dec;159(12):4033-4042

Department of Molecular Physiology and Biophysics, The University of Iowa Carver College of Medicine, Iowa City, Iowa.

By mediating estrogen synthesis and follicular growth in response to FSH, the ovarian FSH receptor (FSHR) is essential for female fertility. Indeed, ovarian stimulation via administration of FSH to women with infertility is part of the primary therapeutic intervention used in assisted reproductive technology. In physiological and therapeutic contexts, current dogma dictates that once ovulation has occurred, FSH/FSHR signaling is no longer required for successful pregnancy outcomes. Read More

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December 2018
6 Reads

Targeting two pathways to treat obesity and T2DM.

Authors:
Claire Greenhill

Nat Rev Endocrinol 2018 Dec;15(1)

Nature Reviews Endocrinology, .

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December 2018