7,702 results match your criteria Endocrinologia y Nutricion [Journal]


Hyperglycemia differentially affects proliferation, apoptosis, and BNIP3 and p53 mRNA expression of human umbilical cord Wharton's jelly cells from non-diabetic and diabetic pregnancies.

Biochem Biophys Res Commun 2018 Dec 13. Epub 2018 Dec 13.

Coordinación de Endocrinología Ginecológica y Perinatal, INPer, Mexico.

Diabetes in pregnancy constitutes an unfavorable environment for embryonic and fetal development, where the child has a higher risk of perinatal morbidity and mortality, with high incidence of congenital malformations and predisposition to long-term metabolic diseases that increase with a hypercaloric diet. To analyze whether hyperglycemia differentially affects proliferation, apoptosis, and mRNA expression in cells from children of normoglycemic pregnancies (NGPs) and diabetes mellitus pregnancies (DMPs), we used umbilical cord Wharton jelly cells as a research model. Proliferation assays were performed to analyze growth and determine the doubling time, and the rate of apoptosis was determined by flow cytometry-annexin-V assays. Read More

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December 2018

Publisher Correction: Obestatin controls skeletal muscle fiber-type determination.

Sci Rep 2018 Dec 14;8(1):17978. Epub 2018 Dec 14.

Área de Endocrinología Celular y Molecular, Instituto de Investigación Sanitaria de Santiago (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS), Servicio Gallego de Salud (SERGAS), Santiago de Compostela, Spain.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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December 2018

Reference TSH levels in Spanish pregnant women. Is it possible to unify criteria?

Endocrinol Diabetes Nutr 2018 Dec 11. Epub 2018 Dec 11.

Servicio de Análisis Clínicos, Hospital do Meixoeiro, Complexo Hospitalario Universitario, Xerencia de Xestión Integrada de Vigo, Vigo (Pontevedra), España.

Introduction: Specific TSH and free thyroxine ranges are needed to adequately assess maternal thyroid function during pregnancy.

Aim: The aim of this review is to review studies reporting data on references TSH and free thyroxine levels in Spanish women during the first trimester of pregnancy.

Material And Methods: Literature search and selection of studies providing reference TSH ranges in the first trimester of pregnancy. Read More

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December 2018
2 Reads

Cutaneous metastasis from Hürthle cell follicular thyroid carcinoma.

Rev Esp Med Nucl Imagen Mol 2018 Dec 11. Epub 2018 Dec 11.

Servicio de Medicina Nuclear, Hospital Universitario Virgen Macarena, Sevilla, España.

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December 2018
2 Reads

Combined therapy with levothyroxine and liothyronine for hypothyroidism.

Medwave 2018 Dec 14;18(8):e7376. Epub 2018 Dec 14.

Proyecto Epistemonikos, Santiago, Chile; Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.

Introduction: The usual supplementation for hypothyroidism is based on monotherapy with levothyroxine. However, some patients persist with symptoms attributable to the deficit of thyroid hormone. It has been suggested that the a combined treatment with liothyronine and levothyroxine would provide a greater benefit. Read More

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December 2018

Genetic variants in DNMT1 and the risk of cardiac autonomic neuropathy in females with Type 1 diabetes.

J Diabetes Investig 2018 Dec 11. Epub 2018 Dec 11.

Laboratório de Carboidratos e Radioimunoensaio LIM-18, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR. Av. Dr. Arnaldo, 455São Paulo, SP, BR.

Aims/introduction: Epigenetics participate in the pathogenesis of metabolic memory, a situation in which hyperglycemia exerts prolonged deleterious effects even after its normalization. We tested the hypothesis that genetic variants in an epigenetic gene could predispose to diabetes complications.

Material And Methods: We assessed the frequency of 5 single nucleotide polymorphisms (SNPs) in the gene encoding DNA methytransferase 1 (DNMT1; rs8112895, rs7254567, rs11085721, rs17291414, and rs10854076) and their associations with diabetic kidney disease, retinopathy, distal polyneuropathy and autonomic cardiovascular neuropathy (CAN) in 359 long-term Type 1 diabetes individuals. Read More

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December 2018
1 Read

Leptin and IGF1 receptors in alpaca (Vicugna pacos) ovaries.

Anim Reprod Sci 2018 Dec 6. Epub 2018 Dec 6.

Instituto de Investigación y Tecnología en Reproducción Animal (INITRA), Facultad de Ciencias Veterinarias, UBA, Buenos Aires, Argentina.

Folliculogenesis and ovulation are regulated by gonadotrophins and other factors such as Insulin like growth factor 1 (IGF1) and leptin. In various species the presence of IGF1 receptor (IGF1R) and leptin receptor (ObR) has been detected in the ovary, but not in the alpaca. Thus, the aim of the present study was to evaluate the presence of these receptors in this tissue and analyze if the presence of these receptors in the ovary is related to the presence of a corpus luteum (CL) and if abundances, as determined by immunostaining intensity vary with follicle size. Read More

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December 2018

Determinants of inertia with lipid-lowering treatment in patients with type 2 diabetes mellitus.

Endocrinol Diabetes Nutr 2018 Dec 9. Epub 2018 Dec 9.

Unidad de Atención Primaria, Gerencia de Servicios Sanitarios de Lanzarote, Lanzarote, España.

Objective: To assess the control of cLDL in diabetic patients, to measure the impact on such control of inertia with lipid-lowering agents and to explore factors that allow for predicting this inertia.

Methods: Study of historical cohorts of diabetic patients. The proportion of patients who achieved the target cLDL levels was estimated. Read More

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December 2018

Primary malignant tumors of the adrenal glands.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e756s. Epub 2018 Dec 10.

Unidade de Suprarrenal, Laboratorio de Hormonios e Genetica Molecular LIM/42, Servico de Endocrinologia e Metabologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Malignancy must be considered in the management of adrenal lesions, including those incidentally identified on imaging studies. Adrenocortical carcinomas (ACCs) are rare tumors with an estimated annual incidence of 0.7-2 cases per year and a worldwide prevalence of 4-12 cases per million/year. Read More

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December 2018

A Combination of Proteomic Approaches Identifies A Panel of Circulating Extracellular Vesicle Proteins Related to the Risk of Suffering Cardiovascular Disease in Obese Patients.

Proteomics 2018 Dec 7:e1800248. Epub 2018 Dec 7.

Platelet Proteomics Group. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade Santiago de Compostela, and Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.

Plasma-derived extracellular vesicles (EVs) have been extensively described as putative biomarkers in different diseases. Interestingly, increased levels of EVs subpopulations are well-known to associate with obesity. The goal of this study was to identify EVs-derived biomarkers in plasma from obese patients in order to predict the development of pathological events associated with obesity. Read More

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December 2018
1 Read

Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial.

Am J Clin Nutr 2018 Sep;108(3):485-491

Departamento de Endocrinología y Metabolismo, and.

Background: Recently, the absence of metabolic effects from nonnutritive sweeteners has been questioned.

Objective: The aim of this study was to evaluate the effects of sucralose consumption on glucose metabolism variables.

Design: We performed a randomized controlled trial involving healthy subjects without comorbidities and with a low habitual consumption of nonnutritive sweeteners (n = 33/group). Read More

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September 2018

[Spontaneous remission of acromegaly and Cushing's disease in older patients. Report of two cases].

Rev Med Chil 2018 Jul;146(7):933-937

Departamento de Neurología y Neurocirugía, Hospital Clínico de la Universidad de Chile, Santiago, Chile.

Pituitary diseases such as acromegaly and Cushing's disease require surgical or medical therapy. In some functioning pituitary tumors, a spontaneous remission of hormonal hypersecretion is observed, mainly associated to apoplexy or pituitary infarction. We report the evolution of two female patients older than 70 years at the time of diagnosis, with multiple comorbidities. Read More

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July 2018
1 Read

[Índices para la evaluación de la resistencia a la insulina en individuos mexicanos sin diabetes].

Gac Med Mex 2018 ;154(Supp 2):S50-S55

Departamento de Endocrinología y Metabolismo, Ciudad de México, México.

Objective: To evaluate the correlation between subrogate index for the evaluation of insulin resistance with the M value obtained with the euglycemic-hyperinsulinemic clamp as well as their sensitivity, specificity, and positive and negative predictive values.

Method: The euglycemic-hyperinsulinemic clamp was performed in subjects having both normal fasting glucose and glycated hemoglobin concentrations. HOMA-IR, QUICKI, HOMA2%S, TyG, TyG*body mass index (BMI) and triglyceride/HDL indexes were calculated. Read More

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January 2018

[Efectos sobre el perfil metabólico, el índice de masa corporal, la composición corporal y la comorbilidad en adolescentes con obesidad mórbida, que han fallado al manejo conservador para bajar de peso, operados de manga gástrica laparoscópica. Reporte del primer grupo de cirugía bariátrica pediátrica en México].

Gac Med Mex 2018 ;154(Supp 2):S22-S29

Departamento de Endocrinología. Hospital Infantil de México Federico Gómez, Ciudad de México, México.

Introduction: Obesity is a world pandemic; in Mexico 3 out of 10 adolescents suffer from it. Conservative management of morbid obesity is not effective and bariatric surgery is the only useful therapy. International pediatric bariatric surgery series are scarce and in Mexico there is limited experience. Read More

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January 2018

Liraglutide in a real-world setting: Joint modeling of metabolic response, prediction of efficacy, and cardiovascular risk.

Endocrinol Diabetes Nutr 2018 Dec 6. Epub 2018 Dec 6.

Servicio Endocrinología, Complejo Hospitalario Universitario de Vigo, Spain.

Introduction And Objectives: The worldwide prevalence of type 2 diabetes mellitus increases in parallel to that of obesity. Liraglutide (LRG), a glucagon-like peptide-1 receptor agonist, can reduce body weight. This study assessed the metabolic efficacy of LRG in real-world clinical practice. Read More

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December 2018

Update on postprandial hyperglycaemia: the pathophysiology, prevalence, consequences and implications of treating diabetes.

Rev Clin Esp 2018 Dec 7. Epub 2018 Dec 7.

Unidad de Referencia de Diabetes, Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valencia, Valencia, España. Electronic address:

To achieve appropriate glycaemic control, postprandial and baseline hyperglycaemia should be reduced. Various epidemiological studies have suggested an association between fluctuations in postprandial blood glucose and cardiovascular risk. However, studies of interventions performed to date have not shown that selective control of postprandial hyperglycaemia is associated with cardiovascular benefits. Read More

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December 2018

Difficult-to-diagnose diabetes in a patient treated with cyclophosphamide - the contradictory roles of immunosuppressant agents: a case report.

J Med Case Rep 2018 Dec 10;12(1):364. Epub 2018 Dec 10.

Unidad de Investigación Médica en Endocrinología Experimental, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauhtémoc 330, Colonia Doctores, 06720, Mexico City, Mexico.

Background: Cyclophosphamide may induce autoimmune diabetes through a decrease in suppressor T cells and increase of proinflammatory T helper type 1 response in animal models. In humans, this association is not as clear due to the presence of other risk factors for hyperglycemia, but it could be a precipitant for acute complications.

Case Presentation: A 31-year-old Mestizo-Mexican woman with a history of systemic lupus erythematosus presented with severe diabetic ketoacidosis, shortly after initiating a multi-drug immunosuppressive therapy. Read More

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December 2018

Pharmacological treatment of obesity

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):395-409. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez”, Unidad de Investigación Médica en Endocrinología Experimental. Ciudad de México, México

More than 70% of the population in Mexico is overweight or obese, affecting mainly people in productive age. Obesity is associated with the development of diseases that increase cardiovascular risk (diabetes mellitus, hypertension or atherogenic dyslipidemia), diseases that limit the quality of life of the patient (osteoarthrosis or sleep apnea) and even with the increase in the incidence of certain types of cancer (breast or colon). It is evident that the decrease of at least 5% of body weight induces improvement in all these factors; however, in some patients it is difficult to achieve this goal only with lifestyle modifications. Read More

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November 2018
2 Reads

Prolactin induces IL-2 associated TRAIL expression on natural killer cells from chronic hepatitis C patients in vivo and in vitro.

Endocr Metab Immune Disord Drug Targets 2018 Dec 6. Epub 2018 Dec 6.

Laboratorio de Hígado, Páncreas y Motilidad (HIPAM) - Unidad de Investigación en Medicina Experimental, Facultad de Medicina, UNAM. Mexico.

Background: Natural killer cells (NKC) are a major component of innate immune response to HCV, mediating their effects through TRAIL and IFN-γ. However, their function is diminished in chronic HCV patients (HCVp). Prolactin is an immunomodulatory hormone capable of activating NKC. Read More

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December 2018
3 Reads

A Review of Practical Issues on the Use of Glucagon-Like Peptide-1 Receptor Agonists for the Management of Type 2 Diabetes.

Diabetes Ther 2018 Nov 30. Epub 2018 Nov 30.

Eli Lilly and Company, Madrid, Spain.

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are well established as effective treatments for patients with type 2 diabetes. GLP-1 RAs augment insulin secretion and suppress glucagon release via the stimulation of GLP-1 receptors. Although all GLP-1 RAs share the same underlying mechanism of action, they differ in terms of formulations, administration, injection devices and dosages. Read More

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November 2018
4 Reads

Inflammatory gene expression in adipose tissue according to diagnosis of anxiety and mood disorders in obese and non-obese subjects.

Sci Rep 2018 Nov 30;8(1):17518. Epub 2018 Nov 30.

Unidad de Gestión Clínica Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Málaga, Spain.

Psychiatric disorders have been widely reported to be associated with systemic inflammation upregulation and adiposity. However, there are no data that link adipose tissue inflammation to these mental disorders. The analysis of adipokines and inflammation-related markers in adipose tissue could help to elucidate the potential association between obesity and mental health. Read More

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November 2018
1 Read
5.078 Impact Factor

[Short-term safety profile of cross-hormonal therapy in trans-male subjects].

Medicina (B Aires) 2018 ;78(6):399-402

Laboratorio de Endocrinología Hospital Carlos G. Durand, Buenos Aires, Argentina.

A trans-male (TM) is a biologically female person with male gender identity who wishes to acquire male sexual characteristics and fulfil a male social role. To achieve that purpose, both cross-hormonal therapy (CHT) and surgical phalloplasty can be used. We evaluated the short term (12 months) safety profile of CHT using different forms of testosterone available for prescription in Argentina. Read More

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January 2018
1 Read

The benign-malignant paradigm in pituitary neuroendocrine tumors and the metaphor of the semaphore: Reflections of a pathologist.

Endocrinol Diabetes Nutr 2018 Nov 29. Epub 2018 Nov 29.

Instituto de Anatomía Patológica, Facultad de Medicina, Universidad de Lisboa, Lisboa, Portugal; Departamento de Medicina/Endocrinología, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, España. Electronic address:

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November 2018
3 Reads

Efficacy of sodium glucose cotransporter 2 inhibitors as an adjunct treatment for patients with diabetes type 2.

Med Clin (Barc) 2018 Nov 29. Epub 2018 Nov 29.

Hospital Central de Asturias, Servicio de Endocrinología y Nutrición, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.

Objective: To analyze the effect of sodium glucose cotransporter 2 (SGLT2) inhibitors in a group of insulin-dependent type 2 diabetes mellitus (T2D) patients.

Patients And Methods: One hundred and five insulin treated T2D patients were enrolled. Primary endpoints were: fasting plasma glucose, HbA1c, weight, total insulin doses (TDI), total basal insulin (TDB) and total rapid insulin (TDR). Read More

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November 2018

Prevalence of overweight and obesity and associated factors in school children and adolescents in a medium-sized Brazilian city.

Clinics (Sao Paulo) 2018 Nov 29;73:e438. Epub 2018 Nov 29.

Divisao de Endocrinologia, Universidade Federal do Triangulo Mineiro, Uberaba, MG, BR.

Objectives: The objective of this study was to describe the prevalence of overweight and obesity in school children and adolescents in a medium-sized Brazilian city.

Methods: In total, 1,125 children and adolescents between the ages of 5.6 and 18 years from public and private schools participated in the study. Read More

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November 2018
2 Reads

Corrigendum: Altered Gut Microbiota and Compositional Changes in and in Mexican Undernourished and Obese Children.

Front Microbiol 2018 16;9:2693. Epub 2018 Nov 16.

Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química UNAM-INMEGEN, Instituto Nacional de Medicina Genómica, México City, Mexico.

[This corrects the article DOI: 10.3389/fmicb.2018. Read More

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November 2018

Patient care in the Endocrinology and Nutrition Units of the National Health System. The RECALSEEN study.

Endocrinol Diabetes Nutr 2018 Nov 30. Epub 2018 Nov 30.

Hospital Universitario Gregorio Marañón, Madrid, España.

Objectives: To elaborate a diagnosis of the situation regarding the assistance in the Services and Units of Endocrinology and Nutrition (S°EyN) of the National Health System of Spain (SNHS) and to develop, based on the results obtained, proposals for improvement policies in the S°EyN.

Material And Methods: Cross-sectional descriptive study of the patients treated in the S°EyN departments of acute general hospitals of the SNHS in 2016. Data were obtained through RECALSEEN 2017, an "ad hoc" survey designed specifically for this purpose, and the Minimum Basic Data Set of discharges given by the S°EN of the SNHS (2015). Read More

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November 2018
1 Read

A Pilot Study of Serum Sphingomyelin Dynamics in Subjects with Severe Obesity and Non-alcoholic Steatohepatitis after Sleeve Gastrectomy.

Obes Surg 2018 Nov 28. Epub 2018 Nov 28.

Unidad Gestión Clínica Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Campus de Teatinos s/n, 29010, Malaga, Spain.

Background: Non-alcoholic steatohepatitis (NASH) is present in a high percentage of obese patients undergoing bariatric surgery. A significant proportion of patients still present NASH even after considerable weight loss and metabolic improvements after surgery.

Objective: To determine whether the changes in the serum lipidome after sleeve gastrectomy could be used to discriminate obese patients with NASH patients to those with non-alcoholic fatty liver (NAFL). Read More

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November 2018
1 Read

Importance of gut microbiota in obesity.

Eur J Clin Nutr 2018 Nov 28. Epub 2018 Nov 28.

Unidad de Gestión Clínica Endocrinología y Nutrición. Instituto de Investigación Biomédica de Málaga (IBIMA), Complejo Hospitalario de Málaga (Virgen de la Victoria)/Universidad de Málaga, Málaga, Spain.

Recently, a number of studies have related the development of highly prevalent disorders such as type 2 diabetes and obesity to gut microbiota. Obesity itself have been associated with modifications in gut microbiota composition, and a tendency towards an overgrowth of microorganisms that obtain more efficient energy from diet. It's capacity to decompose the polysaccharides that can not be digested by the host, increase monosaccharide and short chain fatty acid (SCFA) production. Read More

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November 2018

Cardiovascular risk reduction over time in patients with diabetes or pre-diabetes undergoing bariatric surgery: data from a single-center retrospective observational study.

BMC Endocr Disord 2018 Nov 28;18(1):90. Epub 2018 Nov 28.

Departamento de Endocrinología y Nutrición, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Background: Bariatric surgery is effective in remission of obesity comorbidities. This study was aimed at comparing CVD risk between morbidly obese patients with type 2 diabetes and pre-diabetes before and after bariatric surgery as well as assessing comorbidities.

Methods: This is a retrospective observational study with 105 patients with type 2 diabetes (DMbaseline) and prediabetes (preDMbaseline) who underwent Roux-en-Y gastric bypass. Read More

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November 2018

Activation of AMPK by Medicinal Plants and Natural Products: Its Role in Type 2 Diabetes Mellitus.

Mini Rev Med Chem 2018 Nov 28. Epub 2018 Nov 28.

Departament de Farmacologia, Facultat de Farmàcia, Universitat de València. Spain.

Type-2 diabetes (T2D) is a metabolic disease characterized by permanent hyperglycemia, whose development can be prevented or delayed by using therapeutic agents and implementing lifestyle changes. Some therapeutic alternatives include regulation of glycemia through modulation of different mediators and enzymes, such as AMP-activated protein kinase (AMPK), a highly relevant cellular energy sensor for metabolic homeostasis regulation, with particular relevance in the modulation of liver and muscle insulin sensitivity. This makes it a potential therapeutic target for antidiabetic drugs. Read More

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November 2018

Corticotropin secreting pancreatic neuroendocrine tumour, a therapeutic management challenge. A presentation of 2 cases.

Endocrinol Diabetes Nutr 2018 Nov 24. Epub 2018 Nov 24.

Servicio de Endocrinología y Nutrición, Hospital Universitari de Bellvitge (HUB), l'Hospitalet de Llobregat, Barcelona, España.

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November 2018

Monitoring of treament adherence with easypodTM in 6 Italian centres: a real-world experience.

Minerva Endocrinol 2018 Nov 26. Epub 2018 Nov 26.

U.O. Endocrinologia, Azienda Ospedaliera San Camillo-Forlanini, Rome, Italy.

Background: A poor adherence to r-hGH therapy is associated to a low growth rate in patients with growth deficiency. For this reason, the choice of an objective method, such as an electronic device, for monitoring treatment adherence is very important. This retrospective study evaluated the r-hGH treatment adherence of patients with growth deficiency, monitored through the easypodTM device. Read More

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November 2018
1 Read

The role of myeloid-derived suppressor cells in chronic infectious diseases and the current methodology available for their study.

J Leukoc Biol 2018 Nov 27. Epub 2018 Nov 27.

Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

An effective pathogen has the ability to evade the immune response. The strategies used to achieve this may be based on the direct action of virulence factors or on the induction of host factors. Myeloid-derived suppressor cells (MDSCs) are immune cells with an incredible ability to suppress the inflammatory response, which makes them excellent targets to be exploited by pathogenic bacteria, viruses, or parasites. Read More

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November 2018
3 Reads

Analysis of a clinical pathway for home enteral nutrition in the Region of Murcia. Consumption and associated expenses and adaptation to the National Health System Guide.

Endocrinol Diabetes Nutr 2018 Nov 23. Epub 2018 Nov 23.

Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España; Departamento de Medicina Interna, Universidad de Murcia, Murcia, España.

Objective: To analyze the compliance with the Guide for home enteral nutrition (HEN) of the Spanish national health system of the prescriptions made in a specific area (Health Area I of the Region of Murcia) before and after implementation of a clinical pathway based on that guide, and to compare the changes in healthcare costs of diet therapy during the 2007-2014 period in the Regional and National Health system.

Method: A descriptive study to quantify compliance with the main criteria of the HEN guide before (2010) and after (2013-2014) implementation of the clinical pathway. Changes in health expenditure and consumption during the 2007-2014 period were also analyzed. Read More

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November 2018

The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-sized adipocytes.

Eur J Endocrinol 2018 Nov 1. Epub 2018 Nov 1.

C Aguilar-Salinas, Endocrinology and metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Objective: A haplotype at chromosome 17p13 that reduces expression and function of the solute carrier transporter SLC16A11 is associated with increased risk for type 2 diabetes in Mexicans. We aim to investigate the detailed metabolic profile of SLC16A11 risk haplotype carriers to identify potential physiological mechanisms explaining the increased type 2 diabetes risk.

Design: Cross-sectional study. Read More

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November 2018
4 Reads

Efficacy and Safety of IDegAsp Versus BIAsp 30, Both Twice Daily, in Elderly Patients with Type 2 Diabetes: Post Hoc Analysis of Two Phase 3 Randomized Controlled BOOST Trials.

Diabetes Ther 2018 Nov 24. Epub 2018 Nov 24.

Diabetes Research Unit Cymru, Swansea University, ABM University Health Board, Swansea, UK.

Introduction: The majority of elderly patients (≥ 65 years of age) with type 2 diabetes mellitus (T2DM) will eventually require insulin therapy, but they are particularly vulnerable to hypoglycemia and challenging to treat. Insulin degludec/insulin aspart (IDegAsp) is a novel co-formulation of 70% insulin degludec and 30% insulin aspart administered in a single injection, either once or twice daily with main meals.

Methods: A combined analysis of the phase 3 BOOST INTENSIFY PREMIX I (NCT01009580) and BOOST INTENSIFY ALL (NCT01059812) trials has previously reported lower rates of hypoglycemia during the maintenance period in patients with T2DM treated with IDegAsp twice daily (BID) versus biphasic insulin aspart 30 (BIAsp 30) BID. Read More

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November 2018
2 Reads

Excess Weight in Spain: Current Situation, Projections for 2030, and Estimated Direct Extra Cost for the Spanish Health System.

Rev Esp Cardiol (Engl Ed) 2018 Nov 23. Epub 2018 Nov 23.

Grupo de investigación REGICOR, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain; CIBER de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Introduction And Objectives: Excess weight promotes the development of several chronic diseases and decreases quality of life. Its prevalence is increasing globally. Our aim was to estimate the trend in excess weight between 1987 and 2014 in Spanish adults, calculate cases of excess weight and its direct extra costs in 2006 and 2016, and project its trend to 2030. Read More

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November 2018
1 Read

Methylome profiling of healthy and central precocious puberty girls.

Clin Epigenetics 2018 Nov 22;10(1):146. Epub 2018 Nov 22.

Division of Endocrinology & Metabolism, Development Endocrinology Unit, Laboratory of Hormones and Molecular Genetics/LIM42, Clinical Hospital, Sao Paulo Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil.

Background: Recent studies demonstrated that changes in DNA methylation (DNAm) and inactivation of two imprinted genes (MKRN3 and DLK1) alter the onset of female puberty. We aimed to investigate the association of DNAm profiling with the timing of human puberty analyzing the genome-wide DNAm patterns of peripheral blood leukocytes from ten female patients with central precocious puberty (CPP) and 33 healthy girls (15 pre- and 18 post-pubertal). For this purpose, we performed comparisons between the groups: pre- versus post-pubertal, CPP versus pre-pubertal, and CPP versus post-pubertal. Read More

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November 2018
4 Reads

Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain.

Sci Rep 2018 Nov 21;8(1):17155. Epub 2018 Nov 21.

Lab de Endocrinología Molecular, Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Complejo Hospitalario de Santiago (CHUS), A Coruña, Spain.

The incidence of obesity has been increasing dramatically worldwide over the past decades, thus requiring novel and effective therapeutic approaches. OBEX is an oral nutritional supplement composed of antioxidants with antiobesity activity. The effects of OBEX have been tested in vivo and in vitro. Read More

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November 2018
1 Read

Insulin autoimmune syndrome in an occidental woman: a case report and literature review.

Arch Endocrinol Metab 2018 Oct;62(5):566-570

Serviço de Endocrinologia e Diabetes, Hospital Universitário Walter Cantídio - Faculdade de Medicina, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.

Insulin autoimmune syndrome (IAS, Hirata's disease) is a rare hypoglycemic disorder characterized by spontaneous hypoglycemia associated with extremely high circulating insulin levels and positive anti-insulin antibody results. Thus far, most cases have been reported in Asian countries, notably Japan, with few cases reported in western countries. As a possible cause, it is associated with the use of drugs containing sulfhydryl radicals, such as captopril. Read More

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October 2018
3 Reads

Congenital hyperinsulinism in two siblings with ABCC8 mutation: same genotype, different phenotypes.

Arch Endocrinol Metab 2018 Oct;62(5):560-565

Unidad de Endocrinología Pediátrica y Crecimiento, Pediatría, Hospital Clínico Universitario y Universidad de Santiago de Compostela, IDIS, Santiago de Compostela, Spain.

Congenital hyperinsulinism (CHI) is a heterogenous disease caused by insulin secretion regulatory defects, being ABCC8/KCNJ11 the most commonly affected genes. Therapeutic options include diazoxide, somatostatin analogues and surgery, which is curative in focal CHI. We report the case of two siblings (born two years apart) that presented themselves with hypoketotic hyperinsulinemic persistent hypoglycemias during neonatal period. Read More

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October 2018
1 Read

Evaluation of redox profiles in exogenous subclinical hyperthyroidism at two different levels of TSH suppression.

Arch Endocrinol Metab 2018 Oct;62(5):545-551

Departamento de Endocrinologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.

Objective: Evaluate the relationship between exogenous subclinical hyperthyroidism and oxidative stress through the analysis of the redox profile of patients with subclinical hyperthyroidism exogenous (SCH) grade I (TSH = 0.1 to 0.4 IU/mL) and grade II (TSH < 0. Read More

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October 2018
3 Reads

Thyroid cancer burden and economic impact on the Brazilian public health system.

Arch Endocrinol Metab 2018 Oct;62(5):537-544

Divisão de Economia da Saúde, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Objective: Recent data indicates an increasing incidence of thyroid cancer not accompanied by a proportional increase in mortality, suggesting overdiagnosis, which may represent a big public health problem, particularly where resources are scarce. This article aims to describe and evaluate the procedures related to investigation of thyroid nodules and treatment and follow-up of thyroid cancer and the costs for the Brazilian public health system between 2008 and 2015.

Materials And Methods: Data on procedures related to investigation of thyroid nodules and treatment/follow-up of thyroid cancer between 2008 and 2015 in Brazil were collected from the Department of Informatics of the Brazilian Unified Health System (Datasus) website. Read More

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October 2018
4 Reads

DLK1 is a novel link between reproduction and metabolism.

J Clin Endocrinol Metab 2018 Nov 19. Epub 2018 Nov 19.

Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.

Background: Delta-like homolog 1 (DLK1), also called preadipocyte factor 1, prevents adipocyte differentiation and has been considered a molecular gatekeeper of adipogenesis. A DLK1 complex genomic defect was identified in five women from a single family with central precocious puberty (CPP) and increased body fat percentage.

Methods: We studied 60 female patients with a diagnosis of CPP or history of precocious menarche. Read More

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November 2018
5 Reads

Does renal function improve after parathyroidectomy in primary hyperparathyroidism?

Nefrologia 2018 Nov 17. Epub 2018 Nov 17.

Servicio de Nefrología, Hospital Universitario Doce de Octubre, Madrid, España; Departamento de Medicina, Universidad Complutense, Madrid, España.

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterised by hypercalcaemia and parathormone increase. Decreased glomerular filtration rate (<60ml/min) continues to be a parathyroidectomy (PTX) criterion in asymptomatic PHPT. The influence of PTX on renal function evolution is the subject of debate. Read More

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November 2018
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Optimization of the follow-up of pregnant women with autoimmune thyroid disease.

Endocrinol Diabetes Nutr 2018 Nov 16. Epub 2018 Nov 16.

Servicio de Endocrinología y Nutrición, Complejo Hospitalario de Navarra, Pamplona, Navarra, España; Instituto de Investigación Sanitaria de Navarra (IdisNa), Pamplona, Navarra, España.

Objective: To determine the risk of hypothyroidism in pregnant women with autoimmune thyroid disease and thyrotropin (TSH) < 2,5 mIU/l at the beginning of pregnancy.

Methods: Prospective longitudinal study of pregnant women with no personal history of thyroid disease, and with TSH < 2.5 mIU/l in the first trimester. Read More

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November 2018
4 Reads

Evaluation of the effect of Lactobacillus reuteri V3401 on biomarkers of inflammation, cardiovascular risk and liver steatosis in obese adults with metabolic syndrome: a randomized clinical trial (PROSIR).

BMC Complement Altern Med 2018 Nov 20;18(1):306. Epub 2018 Nov 20.

Department of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain.

Background: Obesity is characterized by increased fat mass and is associated with the development of insulin resistance syndrome (IRS), usually known as metabolic syndrome. The alteration of the intestinal microbiota composition has a role in the development of IRS associated with obesity, and probiotics, which are live microorganisms that confer a health benefit to the host, contribute to restore intestinal microbiota homeostasis and lower peripheral tissue insulin resistance. We aim to evaluate the effects of the probiotic strain Lactobacillus reuteri (L. Read More

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November 2018
5 Reads

Current knowledge on Hashimoto's encephalopathy: a literature review.

Medwave 2018 Oct 22;18(6):e7298. Epub 2018 Oct 22.

Departamento de Endocrinología, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú.

Hashimoto's encephalopathy is a rare disease, with a reported prevalence of 2.1 per 100 000. Clinical manifestations include confusion, decreased state of consciousness, cognitive deficit, seizures, myoclonus, ataxia, and focal neurological deficits. Read More

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October 2018
9 Reads

Predictors of postpartum diabetes mellitus in patients with gestational diabetes.

Endocrinol Diabetes Nutr 2018 Nov 15. Epub 2018 Nov 15.

Servicio de Endocrinología y Nutrición, Hospital Universitario Gregorio Marañón, Madrid, España.

Introduction: Gestational diabetes (GD) is related to development of diabetes mellitus (DM) after delivery. The predictive factors in this association are not yet well defined. Objetive: to study the predictive factors of dysglucosis in the postpartum period in a sample of patients with GD. Read More

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November 2018
7 Reads