559,053 results match your criteria Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists[Journal]


Adipokines Regulate the Expression of Tumor-Relevant MicroRNAs.

Obes Facts 2019 Apr 18;12(2):211-225. Epub 2019 Apr 18.

Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Background: Increasing prevalence of obesity requires the investigation of respective comorbidities, including tumor diseases like colorectal, renal, post-menopausal breast, prostate cancer, and leukemia. To date, molecular mechanisms of the malignant transformation of these peripheral tissues induced by obesity remain unclear. Adipose tissue secretes factors with hormone-like functions, the adipokines, and is therefore categorized as an endocrine organ. Read More

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http://dx.doi.org/10.1159/000496625DOI Listing

Serotonin transporter gene methylation predicts long-term cortisol concentrations in hair.

Psychoneuroendocrinology 2019 Mar 29;106:179-182. Epub 2019 Mar 29.

Chair of Biopsychology, Faculty of Psychology, Technische Universität Dresden, Germany.

Epigenetic signatures, such as DNA methylation (DNA), have been implicated in long-term dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis and related health risks. Based on a wealth of neuroendocrine studies on genetic polymorphisms in the serotonin transporter gene (SLC6A4), this locus constitutes a key candidate to explore associations of DNA patterns and HPA-axis functioning. The few studies addressing this link so far exclusively relied on spot measurements of HPA-axis activity, which may not adequately reflect cortisol output over prolonged periods of time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530193007
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http://dx.doi.org/10.1016/j.psyneuen.2019.03.033DOI Listing
March 2019
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Influence of soft tissue on bone density and microarchitecture measurements by high-resolution peripheral quantitative computed tomography.

Bone 2019 Apr 15. Epub 2019 Apr 15.

Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, THR-1051 Boston, MA, USA; Harvard Medical School, 25 Shattuck St., Boston, MA, USA; Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, One Overland Street, Boston, MA, USA.

High-resolution peripheral quantitative computed tomography (HR-pQCT) is a non-invasive method of measuring volumetric bone mineral density (vBMD) and microarchitecture at the distal radius and tibia. With increasing use of this technology, it is crucial to understand the potential impact of overlying soft tissue on the accuracy of HR-pQCT measures. Thus, we examined the effects of a simulated increase in adiposity (via 6- and 12-mm thick layers of overlying circumferential fat) on HR-pQCT measures of a hydroxyapatite (HA) phantom and in women (n = 20, aged 18-75 years). Read More

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http://dx.doi.org/10.1016/j.bone.2019.04.008DOI Listing

ΔFosB Requires Galanin, but not Leptin, to Increase Bone Mass via the Hypothalamus, but both are needed to increase Energy Expenditure.

J Bone Miner Res 2019 Apr 18. Epub 2019 Apr 18.

Department of Medicine, Harvard Medical School and Endocrine Unit MGH, and Division of Bone and Mineral Metabolism, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.

Energy metabolism and bone homeostasis share several regulatory pathways. The AP1 transcription factor ΔFosB and leptin both regulate energy metabolism and bone, yet whether their pathways intersect is not known. Transgenic mice overexpressing ΔFosB under the control of the Enolase 2 (ENO2) promoter exhibit high bone mass, high energy expenditure, low fat mass and low circulating leptin levels. Read More

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http://dx.doi.org/10.1002/jbmr.3741DOI Listing

Long-term Risk of Thyroid Cancer After Initially Negative Thyroid Biopsy Results.

JAMA Otolaryngol Head Neck Surg 2019 Apr 18. Epub 2019 Apr 18.

Division of General Surgery, Department of Surgery, University Health Network, Toronto, Ontario, Canada.

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http://archotol.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoto.2019.0386DOI Listing
April 2019
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Bifidobacterium longum 1714™ Strain Modulates Brain Activity of Healthy Volunteers During Social Stress.

Am J Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychosomatic Medicine and Psychotherapy, University of Tübingen, Tübingen, Germany.

Objectives: Accumulating evidence indicates that the gut microbiota communicates with the central nervous system, possibly through neural, endocrine, and immune pathways, and influences brain function. B. longum 1714™ has previously been shown to attenuate cortisol output and stress responses in healthy subjects exposed to an acute stressor. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000203DOI Listing

Transgenerational effects of endocrine disrupting chemicals on male and female reproduction.

Endocrinology 2019 Apr 18. Epub 2019 Apr 18.

Department of Comparative Biosciences, University of Illinois, Urbana, IL.

Endocrine disrupting chemicals are known to interfere with normal reproductive function and hormone signaling. Phthalates, bisphenol A, pesticides, and environmental contaminants such as polychlorinated biphenyls and dioxins are known endocrine disrupting chemicals that have been shown to negatively affect both male and female reproduction. Exposure to these chemicals occurs on a daily basis due to these compounds being found in plastics, personal care products, and pesticides. Read More

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2019-00034DOI Listing
April 2019
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Response to Letter to the Editor: Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society* Clinical Practice Guideline.

J Clin Endocrinol Metab 2019 Apr 18. Epub 2019 Apr 18.

Professor of Medicine Tufts University School of Medicine, Maine Medical Center Research Institute, Scarborough, Maine USA.

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2019-00777DOI Listing
April 2019
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Letter to the Editor "Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society* Clinical Practice Guideline."

J Clin Endocrinol Metab 2019 Apr 18. Epub 2019 Apr 18.

Bone Unit, Lausanne University Hospital and University of Lausanne, Switzerland.

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http://dx.doi.org/10.1210/jc.2019-00747DOI Listing

Epidemiological, clinico-biological, therapeutic and evolutionary aspects of β-thalassemia in Morocco.

Ann Biol Clin (Paris) 2019 Apr;77(2):169-173

Laboratoire d'hématologie, Hôpital Avicenne, CHU Mohammed VI, Faculté de médecine et de pharmacie de Marrakech, Maroc.

Objective: Thalassemias is the consequence of a synthesis imbalance between the α and β chains of hemoglobin. It's a hereditary haemolytic anemias, which presents a problem of public health because of their frequency and the difficulties of their care. The objective of this work is to study the epidemiological, clinico-biological, therapeutic and evolutionary profile of thalassemic patients in Morocco. Read More

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http://dx.doi.org/10.1684/abc.2019.1433DOI Listing

Correction to: Discrimination between arterial and venous bowel ischemia by computer-assisted analysis of the fluorescent signal.

Surg Endosc 2019 Apr 17. Epub 2019 Apr 17.

IHU-Strasbourg, Institute of Image-Guided Surgery, 1, Place de l'Hôpital, 67091, Strasbourg, France.

In the original version, Ines Gockel was omitted as a coauthor. The complete author listing is corrected here. Read More

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http://link.springer.com/10.1007/s00464-019-06795-x
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http://dx.doi.org/10.1007/s00464-019-06795-xDOI Listing
April 2019
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Higher ER load is not associated with better outcome in stage 1-3 breast cancer: a descriptive overview of quantitative HR analysis in operable breast cancer.

Breast Cancer Res Treat 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Oncology, Leiden University Medical Centre, Leiden, The Netherlands.

Purpose: In breast cancer, hormone receptor (HR) status is generally a qualitative measure; positive or negative. Quantitatively measured oestrogen and progesterone receptors (ER and PR) are frequently proposed prognostic and predictive markers, some guidelines even provide different treatment options for patients with strong versus weak expression.

Aim: To evaluate quantitative HR load assessed by immunohistochemistry as a prognostic and predictive measure in stage 1-3 breast cancer. Read More

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http://link.springer.com/10.1007/s10549-019-05233-9
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http://dx.doi.org/10.1007/s10549-019-05233-9DOI Listing
April 2019
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[Specific cases of slipped capital femoral epiphysis : Endocrinopathies, hormone therapy and other rare causes].

Orthopade 2019 Apr 17. Epub 2019 Apr 17.

Orthopädische Klinik, Olgahospital, Klinikum Stuttgart, Kriegsbergstr. 62, 70174, Stuttgart, Deutschland.

In slipped capital femoral epiphysis (SCFE) atypical causes can be found in about 5% of cases. The patients' age differs from the typical age of SCFE patients of between age 10 and 16. There are numerous causes of atypical SCFE: different endocrine disorders, sequelae of chronic renal failure and effects of radiation and chemotherapy on the proximal femoral physis. Read More

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http://dx.doi.org/10.1007/s00132-019-03728-3DOI Listing

Paraganglioma of the tongue with SDHB gene mutation in a patient with Graves' disease.

Clin Case Rep 2019 Apr 2;7(4):726-730. Epub 2019 Mar 2.

Hereditary Endocrine Cancer, Human Cancer Genetics Programme Spanish National Cancer Centre (CNIO) Madrid Spain.

We report a case of an apparently sporadic paraganglioma of the tongue with a germ-line mutation in a female patient with asymptomatic Graves' disease. The tongue is an unusual primary location. Genetic testing is mandatory in all cases. Read More

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http://dx.doi.org/10.1002/ccr3.2065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452525PMC
April 2019
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Animal models of polycystic ovary syndrome: A review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides.

Reprod Med Biol 2019 Apr 28;18(2):151-160. Epub 2018 Dec 28.

Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age and a major cause of infertility; however, the pathophysiology of this syndrome is not fully understood. This can be addressed using appropriate animal models of PCOS. In this review, we describe rodent models of hormone-induced PCOS that focus on the perturbation of the hypothalamic-pituitary-ovary (HPO) axis and abnormalities in neuropeptide levels. Read More

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http://dx.doi.org/10.1002/rmb2.12262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452010PMC

Evaluation of referrals for short stature: A retrospective chart review.

Paediatr Child Health 2019 May 13;24(2):e74-e77. Epub 2018 Jun 13.

Children's Hospital, London Health Sciences Centre, London, Ontario.

Background: Referrals to paediatric endocrine clinics for short stature are common. Height velocity (HV) is an essential component of the evaluation of short stature as growth deceleration often reflects an underlying paediatric endocrine diagnosis (PED). Access to previous measurements facilitates prompt calculation of HV. Read More

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https://academic.oup.com/pch/article/24/2/e74/5036792
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http://dx.doi.org/10.1093/pch/pxy079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462116PMC
May 2019
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[Comprehensive treatment of adrenal cortical carcinoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):298-301

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Objective: To investigate the clinical and functional imaging examination and pathological features of adrenocortical carcinoma (ACC), in order to improve the diagnosis and treatment of ACC.

Methods: The clinical data of 93 patients with ACC were analyzed retrospectively. Their diagnosis, surgical treatment and follow-up of mitotane medcine therapy were madeaccording to clinical manifestations, adrenal endocrine function determination, imaging examination characteristics and histopathological results. Read More

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LLGL2 rescues nutrient stress by promoting leucine uptake in ER breast cancer.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Department of Medicine, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Drosophila Lgl and its mammalian homologues, LLGL1 and LLGL2, are scaffolding proteins that regulate the establishment of apical-basal polarity in epithelial cells. Whereas Lgl functions as a tumour suppressor in Drosophila, the roles of mammalian LLGL1 and LLGL2 in cancer are unclear. The majority (about 75%) of breast cancers express oestrogen receptors (ERs), and patients with these tumours receive endocrine treatment. Read More

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http://www.nature.com/articles/s41586-019-1126-2
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http://dx.doi.org/10.1038/s41586-019-1126-2DOI Listing
April 2019
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Placental secretion of apolipoprotein A1 and E: the anti-atherogenic impact of the placenta.

Sci Rep 2019 Apr 17;9(1):6225. Epub 2019 Apr 17.

Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.

High levels of atherogenic lipids in pregnancy are associated with health complications for the mother, the fetus and the newborn. As endocrine secretory tissue, the human placenta releases apolipoproteins (apos), particularly apoA1 and apoE. However, the magnitude and the directionality of the apo secretions remain unknown. Read More

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http://www.nature.com/articles/s41598-019-42522-1
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http://dx.doi.org/10.1038/s41598-019-42522-1DOI Listing
April 2019
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Cinacalcet corrects biased allosteric modulation of CaSR by AHH autoantibody.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Department of Endocrinology and Nephrology, The University of Tokyo School of Medicine, Tokyo, Japan.

Biased agonism is a paradigm that may explain the selective activation of a signaling pathway via a GPCR that activates multiple signals. The autoantibody-induced inactivation of the calcium-sensing receptor (CaSR) causes acquired hypocalciuric hypercalcemia (AHH). Here, we describe an instructive case of AHH in which severe hypercalcemia was accompanied by an increased CaSR antibody titer. Read More

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http://dx.doi.org/10.1172/jci.insight.126449DOI Listing

Man with epigastric pain and persistently elevated serum lipase.

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Queensland Diabetes and Endocrine Centre, Mater Misericordiae Brisbane Ltd, South Brisbane, Queensland, Australia.

Serum lipase and amylase are commonly requested in individuals presenting with abdominal pain for investigation of acute pancreatitis. Pancreatic hyperenzymaemia is not specific for acute pancreatitis, occurring in many other pancreatic and non-pancreatic conditions. Where persistent elevation of serum lipase and amylase occurs in the absence of a diagnosed cause or evidence of laboratory assay interference, ongoing radiological assessment for pancreatic disease is required for 24 months before a diagnosis of benign pancreatic hyperenzymaemia can be made. Read More

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http://dx.doi.org/10.1136/bcr-2019-229208DOI Listing

Genetic communication by extracellular vesicles is an important mechanism underlying stem cell-based therapy-mediated protection against acute kidney injury.

Stem Cell Res Ther 2019 Apr 17;10(1):119. Epub 2019 Apr 17.

Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.

Stem cell-based therapy appears to be a promising new candidate for acute kidney injury (AKI) management. Traditionally, it has been accepted that the mechanism underlying the regenerative effect of stem cells is based on their paracrine/endocrine activity, including release of bioactive factors that act on injured renal cells and presentation of proangiogenic, antiapoptotic, antioxidative, and immunomodulatory effects. Recently, multiple studies have confirmed that extracellular vesicles (EVs) are a kind of vesicle rich in a broad variety of biologically active molecules, including lipids, proteins, and, in particular, nucleic acids. Read More

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http://dx.doi.org/10.1186/s13287-019-1227-8DOI Listing

Proposed endocrine funding priorities for the NICHD strategic plan: expert opinion from the Pediatric Endocrine Society.

Pediatr Res 2019 Apr 17. Epub 2019 Apr 17.

Division of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine UCLA, Los Angeles, CA, USA.

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http://www.nature.com/articles/s41390-019-0401-0
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http://dx.doi.org/10.1038/s41390-019-0401-0DOI Listing
April 2019
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An Extended Endoscopic Endonasal Approach for Sellar Area Chondrosarcoma: A Case Report and Literature Review.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.

Background: Chondrosarcoma is a malignant tumor that originates from mesenchymal cells that have differentiated into chondrocytes, often growing laterally, rarely seen in the cranium, and seldom seen in the saddle area. We believe that only a few cases have been reported in the literature. We report a case of pituitary fossa chondrosarcoma, which was completely resected by an extended endoscopic endonasal approach, and a literature review. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.075DOI Listing

GLP-1 induces alpha cell proliferation and overrides leptin suppression induced by negative energy balance in vagotomized rats.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Endocrine, Cardiovascular & Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

Glucagon-like peptide-1 (GLP-1) influences energy balance by exerting effects on food intake and glucose metabolism, through mechanisms that are partially dependent on the vagal pathway. The aim of this study was to characterize the effects of chronic GLP-1 stimulation on energy homeostasis and glucose metabolism in the absence of vagal innervation Truncal vagotomized (VGX) and sham operated rats (SHAM) received an intraperitoneal GLP-1 infusion (3.5 pmol/kg/min) trough mini-osmotic pumps. Read More

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http://dx.doi.org/10.1002/jcb.28719DOI Listing

Phytotherapeutic medicines: reality or myth?

Rev Assoc Med Bras (1992) 2019 Mar;65(3):292-294

Department of Endocrine Gynecology and Menopause, Discipline of Gynecology and Obstetrics, Hospital das Clínicas, Faculty of Medicine of the University of São Paulo; São Paulo, Brasil.

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.65.3.292DOI Listing
March 2019
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Partner status moderates the relationships between sexual problems and self-efficacy for managing sexual problems and psychosocial quality-of-life for postmenopausal breast cancer survivors taking adjuvant endocrine therapy.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC.

Objective: Past studies indicate that >90% of breast cancer survivors taking adjuvant endocrine therapy (AET) experience menopausal symptoms including sexual problems (eg, vaginal dryness, dyspareunia); however, research examining the impact of these problems on quality-of-life is limited. This cross-sectional study examined (1) the impact of sexual problems and self-efficacy for coping with sexual problems (sexual self-efficacy) on quality-of-life (ie, psychosocial quality-of-life and sexual satisfaction), and (2) partner status as a moderator of these relationships.

Methods: Postmenopausal breast cancer survivors taking AET completed measures of sexual problems (Menopause-Specific Quality-of-Life [MENQOL] sexual subscale], sexual self-efficacy, psychosocial quality-of-life (MENQOL psychosocial subscale), and sexual satisfaction (Functional Assessment of Cancer Therapy-General item). Read More

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http://dx.doi.org/10.1097/GME.0000000000001337DOI Listing
April 2019
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Contemporary Management of Polycystic Ovarian Syndrome.

Clin Obstet Gynecol 2019 Apr 15. Epub 2019 Apr 15.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York.

PCOS remains one of the most intriguing endocrine disorders that physicians encounter even though it was first described over 80 years ago. Although the diagnostic criteria, nomenclature, and ideal therapeutic strategies are areas of active and ongoing debate, there is no doubt that we have made tremendous progress in improving the quality of life and reproductive outcomes of women who suffer from this wide-ranging disorder. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000449DOI Listing
April 2019
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Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach.

Environ Health Perspect 2019 Apr;127(4):47005

1 University Paris Descartes , ComUE Sorbonne Paris Cité, Paris, France.

Background: Available toxicity data can be optimally interpreted if they are integrated using computational approaches such as systems biology modeling. Such approaches are particularly warranted in cases where regulatory decisions have to be made rapidly.

Objectives: The study aims at developing and applying a new integrative computational strategy to identify associations between bisphenol S (BPS), a substitute for bisphenol A (BPA), and components of adverse outcome pathways (AOPs). Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP4200
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http://dx.doi.org/10.1289/EHP4200DOI Listing
April 2019
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A Prospective Study on the Value of Ultrasound Microflow Assessment to Distinguish Malignant from Benign Solid Breast Masses: Association between Ultrasound Parameters and Histologic Microvessel Densities.

Korean J Radiol 2019 May;20(5):759-772

Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.

Objective: To investigate the value of ultrasound (US) microflow assessment in distinguishing malignant from benign solid breast masses as well as the association between US parameters and histologic microvessel density (MVD).

Materials And Methods: Ninety-eight breast masses (57 benign and 41 malignant) were examined using Superb Microvascular Imaging (SMI) and contrast-enhanced US (CEUS) before biopsy. Two radiologists evaluated the quantitative and qualitative vascular parameters on SMI (vascular index, morphology, distribution, and penetration) and CEUS (time-intensity curve analysis and enhancement characteristics). Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3348/kjr.2018.05
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http://dx.doi.org/10.3348/kjr.2018.0515DOI Listing
May 2019
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Comparing the effects of ipragliflozin versus metformin on visceral fat reduction and metabolic dysfunction in Japanese patients with type 2 diabetes treated with sitagliptin: A prospective, multicentre, open-label, blinded-endpoint, randomised controlled study (PRIME-V study).

Diabetes Obes Metab 2019 Apr 17. Epub 2019 Apr 17.

Department of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, Chiba, Japan.

A prospective, multicentre, open-label, blinded-endpoint, randomised controlled study was conducted to evaluate the efficacy of treatment with ipragliflozin (sodium-dependent glucose transporter-2 inhibitor) versus metformin for visceral fat reduction and glycaemic control among Japanese patients with type 2 diabetes treated with sitagliptin, HbA1c levels of 7-10%, and BMI ≥22 kg/m . Patients were randomly assigned (1:1) to receive ipragliflozin 50 mg or metformin 1000-1500 mg daily. The primary outcome was change in visceral fat area as measured by computed tomography after 24 weeks of therapy. Read More

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http://dx.doi.org/10.1111/dom.13750DOI Listing
April 2019
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Risk of incident circulatory disease in patients treated for differentiated thyroid carcinoma with no history of cardiovascular disease.

Clin Endocrinol (Oxf) 2019 Apr 16. Epub 2019 Apr 16.

Institute of Applied Health Research, University of Birmingham, Birmingham, Edgbaston, United Kingdom, B15 2TT.

Context: The incidence of differentiated thyroid cancer (DTC) is increasing, yet the prognosis is favorable and long-term survival is expected. Exogenous TSH suppression has been used for many years to prevent DTC recurrence and may be associated with increased risks of circulatory diseases.

Design: Risks of circulatory disease in patients treated for DTC were compared to randomly matched patients without DTC (controls) up to a 1:5 ratio using age, sex, body mass index (BMI) and smoking as the matching parameters in a population-based, open cohort study using The Health Improvement Network. Read More

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http://dx.doi.org/10.1111/cen.13990DOI Listing

Reproductive history and breast cancer survival: a prospective patient cohort study in Japan.

Breast Cancer 2019 Apr 15. Epub 2019 Apr 15.

Department of Breast Surgery, Miyagi Cancer Center Hospital, 47-1 Nodayama, Medeshima-Shiode, Natori, Miyagi, 981-1239, Japan.

Background: Reproductive factors may influence breast cancer progression and patient survival; however, evidence has been limited.

Methods: The associations of reproductive factors with tumor characteristics and patient survival were analyzed among 1468 breast cancer patients diagnosed during 1997-2013 at a single institute in Japan. The patients were followed until 2016. Read More

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http://link.springer.com/10.1007/s12282-019-00972-5
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http://dx.doi.org/10.1007/s12282-019-00972-5DOI Listing
April 2019
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Activation profiles of monocyte-macrophages and HDL function in healthy women in relation to menstrual cycle and in polycystic ovary syndrome patients.

Endocrine 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, University of Padova, Padova, Italy.

Purpose: Hormonal status and menopause affect human macrophage function and cardiometabolic risk. In polycystic ovary syndrome (PCOS) patients the cardiometabolic risk increases through mechanisms that are largely unknown. We tested the hypotheses that macrophage activation is influenced by menstrual cycle and that ovarian dysfunction in PCOS patients is associated with altered macrophage inflammatory responses and cholesterol efflux capacity of serum HDL. Read More

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http://dx.doi.org/10.1007/s12020-019-01911-2DOI Listing

Risk factors for recurrent macrosomia and child outcomes.

World J Pediatr 2019 Apr 16. Epub 2019 Apr 16.

Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Obstetrics and Gynecology Hospital of Fudan University, 128 Shen Yang Road, Shanghai, 200092, China.

Background: Women who had delivered a macrosomic newborn will have a higher risk to deliver another macrosomia. We aimed to examine the recurrence risk of macrosomia in the subsequent pregnancy and the implications in long-term child health.

Methods: Data from the Collaborative Perinatal Project, a longitudinal birth cohort with 54,371 singleton births, were used. Read More

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http://link.springer.com/10.1007/s12519-019-00249-z
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http://dx.doi.org/10.1007/s12519-019-00249-zDOI Listing
April 2019
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Propagation of functional estrogen receptor positive normal human breast cells in 3D cultures.

Breast Cancer Res Treat 2019 Apr 16. Epub 2019 Apr 16.

Environmental Genomics & Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.

Purpose: Understanding how differentiation, microenvironment, and hormonal milieu influence human breast cell susceptibility to malignant transformation will require the use of physiologically relevant in vitro systems. We sought to develop a 3D culture model that enables the propagation of normal estrogen receptor alpha (ER) + cells.

Methods: We tested soluble factors and protocols for the ability to maintain progenitor and ER + cells in cultures established from primary cells. Read More

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http://link.springer.com/10.1007/s10549-019-05229-5
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http://dx.doi.org/10.1007/s10549-019-05229-5DOI Listing
April 2019
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Reply to Letter to the Editor Regarding "The Importance of Diagnosing Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) Based on the Defined Criteria".

Ann Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Otolaryngology - Head and Neck Surgery/Surgical Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1245/s10434-019-07358-zDOI Listing

Multicenter Phase II Study of Intraoperative Radiotherapy of Early Breast Cancer: Ipsilateral Tumor Recurrence.

Ann Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

Background: We performed a multicenter phase II study on the efficacy and safety of intraoperative radiotherapy (IORT) as partial breast irradiation using multiple devices.

Methods: The primary endpoint was ipsilateral breast tumor recurrence (IBTR). Key inclusion criteria were T < 2. Read More

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http://dx.doi.org/10.1245/s10434-019-07350-7DOI Listing

Incidence and excess mortality of hip fractures in a predominantly Caucasian population in the South of Brazil.

Arch Osteoporos 2019 Apr 16;14(1):47. Epub 2019 Apr 16.

Endocrine Center of UFPR, Universidade Federal do Paraná, Curitiba, Brazil.

Introduction: Osteoporosis is a very common disease, and data on its epidemiology is important for health care strategy implementation. Brazil is a developing country; its population is aging, leading to an expected increase in hip fractures and their undesirable consequences.

Objective: Assess the incidence of osteoporotic hip fractures and subsequent mortality in Southern Brazil as part of a large epidemiological study aiming to reinforce the data for FRAX Brazil. Read More

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http://dx.doi.org/10.1007/s11657-019-0597-yDOI Listing

Association of Kiss1 and GPR54 Gene Polymorphisms with Polycystic Ovary Syndrome among Sri Lankan Women.

Biomed Res Int 2019 12;2019:6235680. Epub 2019 Mar 12.

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder affecting women of reproductive age. Its aetiology, though yet unclear, is presumed to have an oligogenic basis interacting with environmental factors. Kisspeptins are peptide products of Kiss1 gene that control the hypothalamic pituitary (HPG) axis by acting via G protein-coupled receptor known as GPR54. Read More

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https://www.hindawi.com/journals/bmri/2019/6235680/
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http://dx.doi.org/10.1155/2019/6235680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434290PMC
March 2019
5 Reads

Assessment of the Early and Late Complication after Thyroidectomy.

Adv Biomed Res 2019 27;8:14. Epub 2019 Feb 27.

General Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The complications in thyroid surgery have been reported variable in literature. The aim of this study was to evaluate the early and late (3 months after surgery) complication rates of thyroidectomy in a cohort of patients undergoing thyroid surgery at two hospitals of Isfahan University of Medical Science, Iran.

Materials And Methods: This study included 204 patients who candidates for thyroidectomy presenting at Medical Educational Centers of Al-Zahra and Kashani hospitals in Isfahan between March 2016 and March 2017. Read More

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http://dx.doi.org/10.4103/abr.abr_3_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425745PMC
February 2019

Identification of small non-coding RNAs as sperm quality biomarkers for in vitro fertilization.

Cell Discov 2019 9;5:20. Epub 2019 Apr 9.

2State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031 China.

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http://www.nature.com/articles/s41421-019-0087-9
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http://dx.doi.org/10.1038/s41421-019-0087-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453904PMC
April 2019
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Evaluation of physiology knowledge loss in medical students of Ahvaz Jundishapur University of Medical Sciences.

Adv Med Educ Pract 2019 29;10:157-162. Epub 2019 Mar 29.

Physiology Research Center (PRC), Department of Physiology, School of Medicine, Medical Educational and Development Center (EDC), Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,

Purpose: The knowledge loss or longevity of taught lessons is a major concern in medical students and all medical practitioners. This study evaluated the physiology knowledge loss in medical students in Ahvaz Jundishapur University of Medical Sciences in Iran.

Methods: A total of 265 volunteers from medical students who had previously passed the "general exam of medical basic sciences" at the end of fifth semester took a retention test (RT) to evaluate their knowledge loss of physiology. Read More

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http://dx.doi.org/10.2147/AMEP.S189029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445220PMC

Total body irradiation dose and risk of subsequent neoplasms following allogeneic hematopoietic cell transplantation.

Blood 2019 Apr 16. Epub 2019 Apr 16.

Fred Hutchinson Cancer Research Center.

We examined the impact of total body irradiation (TBI) dose and fractionation on risk of subsequent malignant neoplasms (SMN) in the era of reduced intensity and non-myeloablative conditioning regimens for hematopoietic cell transplantation (HCT). Among 4,905 one-year survivors of allogeneic HCT for hematologic malignancies (N=4,500) or non-malignant disorders (N=405) transplanted between 1969-2014 we identified 581 SMNs (excluding squamous and basal cell of skin) in 499 individuals. With a median length of follow-up of 12. Read More

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http://dx.doi.org/10.1182/blood.2018874115DOI Listing

Concentration dependence of human and mouse aryl hydrocarbon receptor responsiveness to polychlorinated biphenyl exposures: Implications for aroclor mixtures.

Xenobiotica 2019 Apr 16:1-9. Epub 2019 Apr 16.

e Department of Biochemistry & Molecular Genetics , University of Louisville School of Medicine , Louisville , KY , USA.

1. Aryl hydrocarbon receptor (AhR) ligands, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs), are endocrine disrupting chemicals associated with nonalcoholic fatty liver disease. This study documents the species-specific differences between mouse (high affinity mAhR) and human AhR (hAhR) activation by PCB congeners and Aroclor mixtures. Read More

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https://www.tandfonline.com/doi/full/10.1080/00498254.2019.1
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http://dx.doi.org/10.1080/00498254.2019.1566582DOI Listing
April 2019
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Undifferentiated spermatogonia regulate expression through NOTCH signaling and drive germ cell differentiation.

FASEB J 2019 Apr 16:fj201802361R. Epub 2019 Apr 16.

Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Cytochrome P450 family 26 subfamily B member 1 (CYP26B1) regulates the concentration of all-trans retinoic acid (RA) and plays a key role in germ cell differentiation by controlling local distribution of RA. The mechanisms regulating expression in postnatal Sertoli cells, the main components of the stem cell niche, are so far unknown. During gonad development, expression of is maintained by Steroidogenic Factor 1 (SF-1) and Sex-Determining Region Y Box-9 (SOX9), which ensure that RA is degraded and germ cell differentiation is blocked. Read More

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http://dx.doi.org/10.1096/fj.201802361RDOI Listing

Current concepts in the diagnosis and management of neuroendocrine neoplasms of unknown primary.

Minerva Endocrinol 2019 Apr 15. Epub 2019 Apr 15.

Endocrine Unit.

Neuroendocrine neoplams (NENs) of unknowm primary origin (UPO-NENs) are advanced neoplasms constituting 11%-22% of all NENs that by definition their primary tissue of origin has not been identified with standard diagnostic work-up. Delineating the primary site of origin of UPO-NENs has important implications for selecting the appropriate treatment and overall prognosis. The small bowel, followed by the lung and pancreas are the most prevalent primary sites of origin of UPO-NENs that are uncovered during an extensive and prolonged diagnostic work-up; however, a number of UPO-NENs may still remain occult even after prolonged follow-up. Read More

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https://www.minervamedica.it/index2.php?show=R07Y9999N00A190
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http://dx.doi.org/10.23736/S0391-1977.19.03012-8DOI Listing
April 2019
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Impact of Socioeconomic Characteristics on Metabolic Control in Children with Type One Diabetes in a Developing Country

J Clin Res Pediatr Endocrinol 2019 Apr 17. Epub 2019 Apr 17.

The National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), University of Jordan, Amman, Jordan

Background: Adequate glycemic control in children with type 1 diabetes reduces the risk of future complications. Identifying factors affecting HbA1c is crucial to achieve adequate metabolic control. We aim to identify possible socioeconomic predictors of poor metabolic control in children with type 1 diabetes in Jordan; which resembles a developing country with limited resources. Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2019.2019.0014DOI Listing

Comparison of the diagnostic accuracy of the current guidelines for detecting insulinoma.

Eur J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

K Müssig, Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.

Objective: Insulinomas are rare pancreatic endocrine tumors characterized by hypoglycemia. Guidelines by the Endocrine Society (ES), the European (ENETS) and the North American (NANETS) Neuroendocrine Tumor Societies provide divergent diagnostic criteria. This study compared the diagnostic accuracy of these different criteria during the 72-h fasting test. Read More

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https://eje.bioscientifica.com/view/journals/eje/aop/eje-18-
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http://dx.doi.org/10.1530/EJE-18-0879DOI Listing
April 2019
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