556,371 results match your criteria Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists[Journal]


Functional Genetic Variation in the Anti-Müllerian Hormone Pathway in Women with Polycystic Ovary Syndrome.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.

Context: PCOS is a highly heritable, common endocrine disorder characterized by hyperandrogenism, irregular menses and polycystic ovaries. PCOS is often accompanied by elevated levels of anti-Müllerian hormone (AMH). AMH inhibits follicle maturation. Read More

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http://dx.doi.org/10.1210/jc.2018-02178DOI Listing
February 2019

Changes of vitamin D-binding protein, and total, bioavailable, and free 25-hydroxyvitamin D in transgender people.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Internal Medicine, Endocrine Section, and Center of Expertise on Gender Dysphoria, Amsterdam, the Netherlands.

Context: Total 25-hydroxyvitamin D [25(OH)D] is mainly bound to vitamin D-binding protein (DBP). Bioavailable 25(OH)D consists of albumin-bound and free 25(OH)D and is available for metabolic processes. As sex steroids influence DBP, hormonal treatment (HT) in transgender people might affect DBP and consequently the available 25(OH)D. Read More

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http://dx.doi.org/10.1210/jc.2018-02602DOI Listing
February 2019

Transoral Robotic Thyroidectomy Versus Conventional Open Thyroidectomy: Comparative Analysis of Surgical Outcomes in Thyroid Malignancies.

J Laparoendosc Adv Surg Tech A 2019 Feb 20. Epub 2019 Feb 20.

5 Division for Endocrine and Minimal Invasive Surgery, Department of Human Pathology in Adulthood and Childhood "G.Barresi," University Hospital "G.Martino," University of Messina, Messina, Italy.

Background: Various approaches for thyroid surgery became possible with the use of robotic systems. Transoral robotic thyroidectomy (TORT) is one of the newest approaches and draws attention because of its cosmetic excellence. In this study, we compared the surgical outcomes of TORT and conventional open thyroidectomy (OT). Read More

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http://dx.doi.org/10.1089/lap.2018.0587DOI Listing
February 2019

A Low Calorie Diet with or without Interval Exercise Training Improves Adiposopathy in Obese Women.

Appl Physiol Nutr Metab 2019 Feb 20. Epub 2019 Feb 20.

University of Virginia, Kinesiology, Charlottesville, Virginia, United States ;

Objective: To test if a low calorie diet plus interval exercise (LCD+INT) improves adiposopathy, an endocrine dysfunction, when compared to an energy deficit matched LCD in obese women.

Methods: Subjects (age: 48.2±2. Read More

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http://dx.doi.org/10.1139/apnm-2018-0717DOI Listing
February 2019

Limited significance of repeated long-term radiological and hormonal examination in nonfunctioning adrenal incidentalomas.

Int Braz J Urol 2018 Dec 18;44. Epub 2018 Dec 18.

Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Purpose: The purposes of the present study were to evaluate growth rate of nonfunctioning adrenal incidentalomas (AIs) and their development to hormonal hypersecretion on follow-up.

Materials And Methods: A retrospective study was conducted from the electronic medical records. A total of 314 patients were diagnosed with adrenal tumors between 2000 and 2016. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0235DOI Listing
December 2018

Perinatal exposure to glyphosate and a glyphosate-based herbicide affect spermatogenesis in mice.

Toxicol Sci 2019 Feb 20. Epub 2019 Feb 20.

Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)- UMR_S 1085, Rennes, France.

Glyphosate is the most widely used herbicide in the world. Several studies have investigated the effects of glyphosate and glyphosate-based-herbicides (GBHs) on male reproduction, but there is still little and conflicting evidence for its toxicity. In this study, we analyzed the effects of glyphosate, alone or in formula, on the male reproductive system. Read More

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http://dx.doi.org/10.1093/toxsci/kfz039DOI Listing
February 2019

The effect of estrone and estradiol on the expression of the orexin/hypocretin system in the porcine uterus during early pregnancy.

Domest Anim Endocrinol 2019 Jan 4;68:11-24. Epub 2019 Jan 4.

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719 Olsztyn, Poland. Electronic address:

Orexin A and B (OXA, OXB) are hypothalamic neuropeptides acting via two receptors, type 1 (OX1R) and 2 (OX2R). Orexins, also known as hypocretins, take part in a common endocrine system regulating metabolism and reproductive functions. Changes in the orexin system expression during the estrous cycle and pregnancy suggest dependence on the local hormonal milieu. Read More

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http://dx.doi.org/10.1016/j.domaniend.2018.12.008DOI Listing
January 2019

Female primary and secondary psychopathic variants show distinct endocrine and psychophysiological profiles.

Psychoneuroendocrinology 2019 Feb 13;104:7-17. Epub 2019 Feb 13.

School of Psychology, The University of New South Wales, Sydney, Australia.

Research with predominantly male samples supports primary and secondary developmental pathways to psychopathy that are phenotypically indistinguishable on aggressive and antisocial behavior. The aim of this study was to examine whether female variants of psychopathy show divergent endocrine (i.e. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.02.011DOI Listing
February 2019

Prenatal noise stress aggravates cognitive decline and the onset and progression of beta amyloid pathology in a mouse model of Alzheimer's disease.

Neurobiol Aging 2019 Jan 30;77:66-86. Epub 2019 Jan 30.

Department of Neuroscience, Canadian Centre for Behavioural Neuroscience (CCBN), University of Lethbridge, Lethbridge, Alberta, Canada. Electronic address:

Environmental distresses occurring during the sensitive periods of early life may exacerbate the vulnerability to develop physical and mental diseases in old age. Studies have shown the impact of prenatal stress (PS) on the endocrine development and reprogramming of hypothalamic-pituitary-adrenal axis functions in association with cognitive development and susceptibility to neuropsychiatric diseases. Long-term exposure to glucocorticoids can damage the brain and intensify the progression of Alzheimer's disease (AD)-like neuropathological changes, especially in females. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.019DOI Listing
January 2019

Thyroid hormone profiles and TSH evaluation during early pregnancy and the transition period in dairy cows.

Theriogenology 2019 Jan 29;129:23-28. Epub 2019 Jan 29.

Clinic for Cattle, Endocrinology Laboratory, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173, Hanover, Germany. Electronic address:

The thyroid hormone axis is one important endocrine system within a complex system of various factors and hormones necessary to establish and maintain pregnancy in cattle and in metabolic adaptations towards lactation. Pregnancy and lactation occur contemporaneously in dairy cows, and have major impacts on thyroid hormones as well as status of the hypothalamus-pituitary thyroid axis influences pregnancy and lactation. As especially the thyroid hormone axis with special focus to TSH is not well studies in the past, the aim of the study was to examine the thyroid hormone axis, especially in heifers during adaptation to the first lactation, to verify the association between lactation and thyroid hormones. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.01.023DOI Listing
January 2019

Thyroid Hormones in Critical Illness.

Crit Care Clin 2019 Apr 24;35(2):375-388. Epub 2019 Jan 24.

Endocrine and Metabolic Unit, Royal Adelaide Hospital, Port Road, Adelaide, South Australia 5000, Australia.

Thyroid hormone is integral for normal function, yet during illness, circulating levels of the most active form (triiodothyronine [T3]) decline. Whether this is an adaptive response in critical illness or contributes to progressive disease has remained controversial. This review outlines the basis of thyroid hormone changes during critical illness and considers the evidence regarding T3 replacement. Read More

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http://dx.doi.org/10.1016/j.ccc.2018.11.012DOI Listing

Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill.

Crit Care Clin 2019 Apr 28;35(2):213-227. Epub 2019 Jan 28.

Department of Medicine, University of Melbourne, Austin Health, Austin Hospital, 145 Studley Road, Heidelberg, Victoria 3084, Australia.

Classic and nonclassic renin-angiotensin systems (RAS) are 2 sides of an ubiquitous endocrine/paracrine cascade regulating blood pressure and homeostasis. Angiotensin II and angiotensin-converting enzyme (ACE) levels are associated with severity of disease in the critically ill, and are central to the physiology and the pathogenesis of circulatory shock. Angiotensin (1-7) and ACE2 act as an endogenous counterregulatory arm to the angiotensin II/ACE axis. Read More

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http://dx.doi.org/10.1016/j.ccc.2018.11.002DOI Listing

Prevalence of diabetes and presence of autoantibodies against zinc transporter 8 and glutamic decarboxylase at diagnosis and at follow up of Graves' disease.

Endocrine 2019 Feb 19. Epub 2019 Feb 19.

Department of Endocrinology, Lund University, SE-221 00, Lund, Sweden.

Purpose: The aim of this work was to investigate, in patients with newly diagnosed Graves' disease (GD), the frequency of islet autoantibodies including autoantibodies against Zink transporter 8 (ZnT8A), as well as to investigate the relation between thyroid autoantibodies, islet autoantibodies and diabetes both before GD diagnosis and at follow-up.

Methods: Blood samples from 278 patients with newly diagnosed GD were analyzed for autoantibodies against glutamic acid decarboxylase (GADA), insulinoma-associated protein-2 (IA2-A), three variants of zinc transporter 8 (ZnT8A), thyroid peroxidase (TPOA) and the TSH receptor (TRAb). Information on other autoimmune diseases, as well as development of diabetes during follow up was gathered from patient's medical journal. Read More

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http://dx.doi.org/10.1007/s12020-019-01852-wDOI Listing
February 2019

A randomized controlled trial comparing a telemedicine therapeutic intervention with routine care in adults with type 1 diabetes mellitus treated by insulin pumps.

Acta Diabetol 2019 Feb 19. Epub 2019 Feb 19.

Maccabi National Juvenile Diabetes Center, Raanana, Israel.

Aim: To examine the effectiveness and safety over a 12-month period of a telemedicine intervention in adults with type 1 diabetes (T1D) treated with insulin pumps.

Methods: 74 T1D patients on insulin pumps for at least 1 year (mean 19.5 [11. Read More

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http://dx.doi.org/10.1007/s00592-019-01300-1DOI Listing
February 2019

Butyrate stimulates hepatic gluconeogenesis in mouse primary hepatocytes.

Exp Ther Med 2019 Mar 28;17(3):1677-1687. Epub 2018 Dec 28.

Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China.

Butyrate is a major short-chain fatty acid (SCFA) produced by microbial fermentation of dietary fiber in the gastrointestinal tract. Butyrate is also a well-known broad-spectrum histone deacetylase (HDAC) inhibitor. Butyrate has been reported to improve energy metabolism in rodents, which is associated with its beneficial effects on skeletal muscle, brown fat tissue and pancreatic β-cells. Read More

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http://dx.doi.org/10.3892/etm.2018.7136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364177PMC

26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation.

Proc Natl Acad Sci U S A 2019 Feb 19. Epub 2019 Feb 19.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115

Pharmacological agents that raise cAMP and activate protein kinase A (PKA) stimulate 26S proteasome activity, phosphorylation of subunit Rpn6, and intracellular degradation of misfolded proteins. We investigated whether a similar proteasome activation occurs in response to hormones and under various physiological conditions that raise cAMP. Treatment of mouse hepatocytes with glucagon, epinephrine, or forskolin stimulated Rpn6 phosphorylation and the 26S proteasomes' capacity to degrade ubiquitinated proteins and peptides. Read More

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http://dx.doi.org/10.1073/pnas.1809254116DOI Listing
February 2019

Development of a binational thyroid cancer clinical quality registry: a protocol paper.

BMJ Open 2019 Jan 28;9(1):e023723. Epub 2019 Jan 28.

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Introduction: The occurrence of thyroid cancer is increasing throughout the developed world and since the 1990s has become the fastest increasing malignancy. In 2014, a total of 2693 Australians and 302 New Zealanders were diagnosed with thyroid cancer, with this number projected to rise to 3650 in 2018. The purpose of this protocol is to establish a binational population-based clinical quality registry with the aim of monitoring and improving the quality of care provided to patients diagnosed with thyroid cancer in Australia and New Zealand. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023723DOI Listing
January 2019

Manganese exposure and association with hormone imbalance in children living near a ferro-manganese alloy plant.

Environ Res 2019 Feb 15;172:166-174. Epub 2019 Feb 15.

Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia, Av. Barão de Jeremoabo, s/n, Ondina, 40170-115 Salvador, Bahia, Brazil; Graduate Program in Pharmacy, College of Pharmacy, Federal University of Bahia, Brazil. Electronic address:

It has been suggested that manganese (Mn) plays a fundamental role in the reproductive system through interference with the regulation of the secretion of hormones related to puberty. The objective of this study was to evaluate the environmental exposure to Mn and its effects on the endocrine regulation of hormones related to puberty in school-aged children living near a ferro-manganese alloy plant. Toenails, occipital hair, and blood samples were collected from 225 children, between 7 and 12 years of age, in four elementary schools in Simões Filho, Bahia, Brazil, who were exposed to different Mn levels owing to different Mn dust deposition rates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00139351193009
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http://dx.doi.org/10.1016/j.envres.2019.02.021DOI Listing
February 2019
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Developmental exposure to a very low dose of bisphenol A induces persistent islet insulin hypersecretion in Fischer 344 rat offspring.

Environ Res 2019 Feb 8;172:127-136. Epub 2019 Feb 8.

Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden. Electronic address:

Background: In children with obesity, accentuated insulin secretion has been coupled with development of type 2 diabetes mellitus (T2DM). Bisphenol A (BPA) is a chemical with endocrine- and metabolism-disrupting properties which can be measured in a majority of the population. Exposure to BPA has been associated with the development of metabolic diseases including T2DM. Read More

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http://dx.doi.org/10.1016/j.envres.2019.02.009DOI Listing
February 2019

[A case report of EIF2AK3-related Wolcott-Rallison syndrome and literature review].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):176-179

Pediatric Intensive Care Unit, Fujian Provincial Maternity and Child Care Center Affiliated to Fujian Medical University, Fuzhou 350001, China.

The patient was a female infant aged 1 month and 29 days. She was admitted to the hospital due to convulsions for 6 days and increased blood glucose level for 5 days. She had unstable blood glucose levels. Read More

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February 2019

Late-onset isolated adrenocorticotropic hormone deficiency caused by nivolumab: a case report.

BMC Endocr Disord 2019 Feb 19;19(1):25. Epub 2019 Feb 19.

Internal Medicine 1, Shimane University Faculty of Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan.

Background: Immune checkpoint inhibitors including nivolumab, an anti-programmed cell death protein 1 antibody, are recently developed cancer immunotherapy agents. Immune checkpoint inhibitors are known to cause autoimmune-related side effects including endocrine dysfunctions. However, there are few reports on late-onset isolated adrenocorticotropic hormone (ACTH) deficiency caused by nivolumab. Read More

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http://dx.doi.org/10.1186/s12902-019-0335-xDOI Listing
February 2019

Trend of various adiposity indices in women with and without history of gestational diabetes: a population-based cohort study.

BMC Endocr Disord 2019 Feb 19;19(1):24. Epub 2019 Feb 19.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24, Parvane Street, Yaman Street, Velenjak, Tehran, Iran.

Background: Data of studies focusing on the trends of adiposity indices among women with prior gestational diabetes mellitus (GDM), are limited and controversial. The aim of this study was to compare overtime trends of adiposity indices in women with and without history of GDM, using data of the long term longitudinal population-based Tehran-Lipid and Glucose-Study (TLGS).

Methods: A total of 3395 eligible women aged (20-50 years), including 801 women with prior history of GDM and 2594 non-GDM controls were recruited from among Tehran-Lipid and Glucose-Study participants. Read More

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http://dx.doi.org/10.1186/s12902-019-0348-5DOI Listing
February 2019

Recent advances in adrenal autoimmunity.

Expert Rev Endocrinol Metab 2009 Jul;4(4):333-348

e Department of Internal Medicine, Via E. Dal Pozzo, 06126 Perugia, Italy.

Autoimmune Addison's disease (AAD) results from the immune-mediated destruction of adrenocortical cells. AAD is a major component of the autoimmune polyendocrine syndromes type 1 (APS 1) and type 2. The adrenal autoimmune process is made evident by the apperance of circulating autoantibodies against the steroidogenic enzyme 21-hydroxylase. Read More

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http://dx.doi.org/10.1586/eem.09.20DOI Listing

Multiple endocrine neoplasia type 1.

Expert Rev Endocrinol Metab 2009 Jul;4(4):371-388

d Department of Metabolic and Endocrine Diseases, PO Box 85090, 3508 AB Utrecht.

Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal-dominant inherited tumor syndrome characterized by hyperplasia and/or tumors in the parathyroid glands, the pancreatic islets, the anterior pituitary and adrenal glands, as well as neuroendocrine tumors in the thymus, lungs and stomach, and tumors in nonendocrine tissues. In 1997, the responsible MEN1 gene was identified as a tumor-suppressor gene and its product was named menin. In this review, guidelines for early diagnosis, including MEN1 gene mutation analysis, and treatment, including periodic clinical monitoring, have been formulated, enabling improvement of life expectancy and quality of life. Read More

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http://dx.doi.org/10.1586/eem.09.22DOI Listing

LC-MS/MS detection of thyroid hormone metabolites in tissue samples.

Expert Rev Endocrinol Metab 2012 Sep;7(5):511-513

b Institut für Experimentelle Endokrinologie, Charité Universitätmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

Evaluation of: Ackermans MT, Kettelarij-Haas Y, Boelen A, Endert E. Determination of thyroid hormones and their metabolites in tissue using SPE UPLC-tandem MS. Biomed. Read More

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http://dx.doi.org/10.1586/eem.12.48DOI Listing
September 2012

Cytochrome P450 1A1: is it involved in disruption of thyroid hormone action by polychlorinated biphenyl?

Expert Rev Endocrinol Metab 2011 Sep;6(5):657-659

a Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Evaluation of: Giera S, Bansal R, Ortiz-Toro TM, Taub DG, Zoeller RT. Individual polychlorinated biphenyl (PCB) congeners produce tissue- and gene-specific effects on thyroid hormone signaling during development. Endocrinology 152(7), 2909-2919 (2011). Read More

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http://dx.doi.org/10.1586/eem.11.54DOI Listing
September 2011

Opioid-induced biochemical alterations of the neuroendocrine axis.

Expert Rev Endocrinol Metab 2011 Sep;6(5):705-713

a Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, TX, USA.

Exogenous opioids have been used for decades to palliate cancer-related pain and other cancer-related manifestations and, more recently, to treat patients with pain not related to oncologic disease. While the goal of opioid treatment is symptomatic relief and improved quality of life, these patients often suffer from adverse side effects, including endocrine system abnormalities, of which hypogonadism is the best known. Opioids may interact with other hypothalamic-pituitary pathways and endocrine end organs, and in most cases these interactions are subtle and the effects unclear. Read More

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http://dx.doi.org/10.1586/eem.11.55DOI Listing
September 2011

Predicting response: identifying molecular determinants of endocrine response and resistance in breast cancer.

Authors:
Alison J Butt

Expert Rev Endocrinol Metab 2011 Sep;6(5):661-663

a Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia and St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, New South Wales 2052, Australia.

Evaluation of: Fernandez-Cuesta L, Anaganti S, Hainaut P, Olivier M. p53 status influences response to tamoxifen but not to fulvestrant in breast cancer cell lines. Int. Read More

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http://dx.doi.org/10.1586/eem.11.53DOI Listing
September 2011

New directions in psychoneuroendocrinology: from methods to applications.

Authors:
Jens C Pruessner

Expert Rev Endocrinol Metab 2011 Nov;6(6):769-771

a McGill Centre for Studies in Aging, Faculty of Medicine, McGill University, 6825 Boulevard LaSalle, Verdun, QC, H4H 1R3, Canada.

The International Society of Psychoneuroendocrinology brings together clinicians and researchers from many different fields, including, but not limited to, neuroscientists, psychiatrists, endocrinologists, immunologists, geneticists and psychologists. The continuous focus of the society is loosely based on stress and endocrine regulation, and its interdisciplinary approach has always been one of its major strengths. Attendees benefit from discussions across a wide range of disciplines. Read More

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http://dx.doi.org/10.1586/eem.11.73DOI Listing
November 2011

Insulin sensitizers for women with polycystic ovarian syndrome.

Expert Rev Endocrinol Metab 2009 Mar;4(2):183-192

b Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, 606 24th Avenue South, Suite 402, Minneapolis, MN 55454, USA.

Polycystic ovarian syndrome (PCOS) is the most frequent endocrine disorder and most common cause of anovulation in women of reproductive age. It is a heterogeneous disorder, characterized by excess androgen, ovulatory dysfunction and/or polycystic ovaries. The syndrome is known for its association with several reproductive problems, including infertility and obstetric adverse effects. Read More

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http://dx.doi.org/10.1586/17446651.4.2.183DOI Listing

A role for corticosteroid-binding globulin variants in stress-related disorders.

Expert Rev Endocrinol Metab 2012 May;7(3):301-308

b Endocrine & Metabolic Unit, The University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia.

Primary stress-related diseases such as chronic fatigue syndrome, fibromyalgia or chronic widespread pain have been associated with altered activity of the hypothalamic-pituitary-adrenal axis due to measured relative hyper- or hypo-cortisolism in basal or experimentally stimulated states. A hereditary risk to development of these diseases has been proposed. Corticosteroid-binding globulin (CBG), a plasma transport vehicle for cortisol, may play a more active role in the hypothalamic-pituitary-adrenal axis. Read More

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http://dx.doi.org/10.1586/eem.12.20DOI Listing

Is prolactin involved in the evolution of atherothrombotic disease?

Expert Rev Endocrinol Metab 2012 May;7(3):345-361

f INSERM, Unit 845, Faculty of Medicine, Research Center in Growth and Signaling, Team 'PRL/GH Pathophysiology', University Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine Necker, Paris, France.

Cardiovascular diseases (CVDs) account for approximately 30% of all deaths globally. The most important cause of CVD is atherothrombosis, in other words, narrowing of the arteries as a result of the deposition of cholesterol and other lipoid substances within the arterial wall. Several endocrine disorders have been linked to this pathological state. Read More

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http://dx.doi.org/10.1586/eem.12.23DOI Listing

Hormonal modulation of cholesterol: experimental evidence and possible translational impact.

Expert Rev Endocrinol Metab 2012 May;7(3):309-318

a Department of Clinical Physiopathology, Endocrine Unit, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies (DENOThe), University of Florence, Florence, Italy.

Alzheimer's disease (AD) is still an incurable condition. There is in vitro evidence that estrogens exert neuroprotective effects; however, their role in the treatment of AD is still controversial. Approximately 10 years ago, a new gene, named seladin-1 (for selective AD indicator-1), was identified and found to be downregulated in brain regions affected by AD. Read More

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http://dx.doi.org/10.1586/eem.12.12DOI Listing

Recent results of basic and clinical research in MEN1: opportunities to improve early detection and treatment.

Expert Rev Endocrinol Metab 2012 May;7(3):331-344

c Department of Metabolic Diseases, University Medical Center, Utrecht, The Netherlands.

Due to the variable expression of multiple endocrine neoplasia type 1 (MEN1), it is difficult to predict the course of the disease. However, knowledge about the normal function of the MEN1 gene product, together with the effects of cellular derangement by subsequent genetic events, has increased considerably. At first, the possible existence of a genotype-phenotype correlation is discussed. Read More

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http://dx.doi.org/10.1586/eem.12.22DOI Listing

Clinical overview of saxagliptin for Type 2 diabetes management.

Authors:
Julio Rosenstock

Expert Rev Endocrinol Metab 2010 Nov;5(6):809-823

a Dallas Diabetes and Endocrine Center, Medical City, 7777 Forest Lane C-685, Dallas, TX 75230, USA.

Saxagliptin (Onglyza™, Bristol-Myers Squibb, NJ, USA and AstraZeneca, DE, USA) is a potent, orally active, once-daily dipeptidyl peptidase-4 inhibitor that is indicated as an adjunct to diet and exercise alone, or in combination with metformin, a thiazolidinedione or a sulfonylurea to improve glycemic control in adults with Type 2 diabetes mellitus. By inhibiting dipeptidyl peptidase-4, saxagliptin increases concentrations of the intact forms of the incretin hormones, glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, prolonging their effects. Saxagliptin also improves β-cell function, increases postprandial insulin secretion and reduces postprandial glucagon secretion. Read More

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http://dx.doi.org/10.1586/eem.10.60DOI Listing
November 2010

Multimodal imaging in functional endocrine pancreatic tumors.

Expert Rev Endocrinol Metab 2010 Nov;5(6):855-866

c Department of Diagnostic Radiology, University Hospital of Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany.

Endocrine pancreatic tumors, also known as pancreatic islet tumors, are rare entities of neuroendocrine origin that are located within the pancreas or in its close proximity. Approximately 50% of these tumors secrete biologically active substances that lead to the development of specific clinical syndromes. Once diagnosis has been established on the basis of clinical and laboratory findings, localization of the source of pathologic hormone secretion is warranted. Read More

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http://dx.doi.org/10.1586/eem.10.57DOI Listing
November 2010

Prophylactic thyroidectomy in multiple endocrine neoplasia type 2.

Expert Rev Endocrinol Metab 2010 Nov;5(6):867-874

a Endocrine Practice and Molecular Laboratory, Brückenstr. 21, 69120 Heidelberg, Germany.

Medullary thyroid carcinoma (MTC) is the main component of the autosomal dominant cancer syndrome multiple endocrine neoplasia type 2 (MEN 2). MEN 2 is caused by autosomal dominant gain-of-function mutations in the RET proto-oncogene. In RET-mutation carriers, an age-related progression has been documented from normal C-cells to premalignant C-cell hyperplasia and finally to MTC with or without cervical lymph node metastases. Read More

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http://dx.doi.org/10.1586/eem.10.58DOI Listing
November 2010

Thyroid dysfunction in pregnancy: optimizing fetal and maternal outcomes.

Expert Rev Endocrinol Metab 2010 Jul;5(4):521-529

b Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, South Wales, UK.

Recent decades have seen a growing awareness of the threat posed by thyroid dysfunction in pregnancy on maternal, fetal and neonatal well-being. Uncontrolled hypothyroidism and hyperthyroidism are associated with adverse obstetrics and fetal outcomes and also affect neurointellectual development in the offspring. Excellent outcomes are, however, achievable with appropriate management. Read More

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http://dx.doi.org/10.1586/eem.10.30DOI Listing

Nonoperative management of primary hyperparathyroidism: the exception rather than the rule.

Expert Rev Endocrinol Metab 2009 Nov;4(6):553-563

b Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, H4/722 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA.

The spectrum of classical primary hyperparathyroidism (pHPT) has expanded from a disabling disease to a largely asymptomatic one, leading to considerable uncertainty regarding which patients with pHPT will truly benefit from operative therapy. In the hands of an experienced endocrine surgeon, parathyroidectomy (PTx) is associated with a greater than 95% cure rate and long-term complication rates of less than 5%. We believe that all patients with pHPT should be referred to an experienced endocrine surgeon for consideration of PTx. Read More

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http://dx.doi.org/10.1586/eem.09.50DOI Listing
November 2009

Profiling Volatile Constituents of Homemade Preserved Foods Prepared in Early 1950s South Dakota (USA) Using Solid-Phase Microextraction (SPME) with Gas Chromatography⁻Mass Spectrometry (GC-MS) Determination.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Chemistry, Dakota State University, Madison, SD 57042, USA.

An essential dimension of food tasting (i.e., flavor) is olfactory stimulation by volatile organic compounds (VOCs) emitted therefrom. Read More

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http://dx.doi.org/10.3390/molecules24040660DOI Listing
February 2019

Divergent Changes in Plasma AGEs and sRAGE Isoforms Following an Overnight Fast in T1DM.

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

School of Kinesiology, University of Michigan, 401 Washtenaw Ave., Ann Arbor, MI 48109, USA.

Advanced glycation end products (AGEs) promote the development of diabetic complications through activation of their receptor (RAGE). Isoforms of soluble RAGE (sRAGE) sequester AGEs and protect against RAGE-mediated diabetic complications. We investigated the effect of an overnight fast on circulating metabolic substrates, hormones, AGEs, and sRAGE isoforms in 26 individuals with type 1 diabetes (T1DM). Read More

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http://dx.doi.org/10.3390/nu11020386DOI Listing
February 2019

In Situ Modification of Reverse Osmosis Membrane Elements for Enhanced Removal of Multiple Micropollutants.

Membranes (Basel) 2019 Feb 13;9(2). Epub 2019 Feb 13.

Technion-Israel Institute of Technology, Wolfson Department of Chemical Engineering, Technion City, Haifa 32000, Israel.

Reverse osmosis (RO) membranes are widely used for desalination and water treatment. However, they insufficiently reject some small uncharged micropollutants, such as certain endocrine-disrupting, pharmaceutically active compounds and boric acid, increasingly present in water sources and wastewater. This study examines the feasibility of improving rejection of multiple micropollutants in commercial low-pressure RO membrane elements using concentration polarization- and surfactant-enhanced surface polymerization. Read More

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http://dx.doi.org/10.3390/membranes9020028DOI Listing
February 2019

Re: Imaging investigations in pregnancy.

Emerg Med Australas 2019 Feb 19. Epub 2019 Feb 19.

Endocrine, Mater Health and The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1111/1742-6723.13249DOI Listing
February 2019

A four-miRNA signature as a novel biomarker for predicting survival in endometrial cancer.

Gene 2019 Feb 16. Epub 2019 Feb 16.

Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China; Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China. Electronic address:

Background: The microRNAs (miRNAs) have been validated as prognostic markers in many cancers. The aim of this study was to identify new miRNA prognostic biomarkers in endometrial cancer (EC) and to develop an expression-based miRNA signature to provide survival risk prediction for EC patients.

Methods: From TCGA database, the miRNA datasets of EC and clinical information were downloaded in April 2018. Read More

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http://dx.doi.org/10.1016/j.gene.2019.01.046DOI Listing
February 2019

Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: influence of adolescence and psychological stress.

Peptides 2019 Feb 16. Epub 2019 Feb 16.

Department of Medicine, Amager and Hvidovre Hospital in Glostrup, University of Copenhagen, Glostrup, Denmark; Department of Medicine O, Endocrine Unit, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark.

In middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.02.005DOI Listing
February 2019

Non-neuroendocrine neoplasms of the pituitary region.

J Clin Endocrinol Metab 2019 Feb 19. Epub 2019 Feb 19.

Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom.

Context: Although the majority of sellar lesions are related to pituitary adenomas, the region gives rise to a variety of neoplasms that can be associated with substantial morbidity and/or mortality.

Evidence Acquisition: Information from reviews and guidelines of relevant societies dealing with such neoplasms, and articles that have provided new developments which made important contributions in their pathogenesis and treatment up to 2018, were obtained: public indexes such as PubMed/MEDLINE were used with the search items.

Evidence Synthesis: Sellar neoplasms have a worse outcome than pituitary adenomas that is related not only to their natural history but also to side effects of therapies and evolving endocrine and/or hypothalamic deficiencies. Read More

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http://dx.doi.org/10.1210/jc.2018-01871DOI Listing
February 2019

Trustworthiness of randomized trials in endocrinology-A systematic survey.

PLoS One 2019 19;14(2):e0212360. Epub 2019 Feb 19.

Endocrinology Division, Department of Internal Medicine, University Hospital "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, México.

Background: Trustworthy (i.e. low risk of bias) randomized clinical trials (RCTs) play an important role in evidence-based decision making. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212360PLOS
February 2019

International Continence Society consensus on the diagnosis and treatment of nocturia.

Neurourol Urodyn 2019 Feb 19. Epub 2019 Feb 19.

Urology Department, University of Philadelphia, Philadelphia, Pennsylvania.

Introduction: Patients with nocturia have to face many hurdles before being diagnosed and treated properly. The aim of this paper is to: summarize the nocturia patient pathway, explore how nocturia is diagnosed and treated in the real world and use the Delphi method to develop a practical algorithm with a focus on what steps need to be taken before prescribing desmopressin.

Methods: Evidence comes from existing guidelines (Google, PubMed), International Consultation on Incontinence-Research Society (ICI-RS) 2017, prescribing information and a Delphi panel (3 rounds). Read More

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http://dx.doi.org/10.1002/nau.23939DOI Listing
February 2019
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