553,359 results match your criteria Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists[Journal]


Non-canonical AR activity facilitates endocrine resistance in breast cancer.

Endocr Relat Cancer 2019 Feb;26(2):251-264

Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

The role of androgen receptor (AR) in endocrine-resistant breast cancer is controversial and clinical trials targeting AR with an AR antagonist (e.g., enzalutamide) have been initiated. Read More

View Article

Download full-text PDF

Source
https://erc.bioscientifica.com/view/journals/erc/26/2/ERC-18
Publisher Site
http://dx.doi.org/10.1530/ERC-18-0333DOI Listing
February 2019
1 Read

Safety and efficacy of two starting doses of vandetanib in advanced medullary thyroid cancer.

Endocr Relat Cancer 2019 Feb;26(2):241-250

Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Vandetanib is an oral tyrosine kinase inhibitor approved for treatment of advanced symptomatic or progressive medullary thyroid cancer (MTC). The current study (Nbib1496313) evaluated the benefit-risk of two starting doses of vandetanib in patients with symptomatic or progressive MTC. Patients were randomized 1:1 to receive vandetanib 150 or 300 mg daily and followed for a maximum of 14 months (Part A), with the option to then enter an open-label phase (Part B) investigating vandetanib 100, 150, 200 and 300 mg daily doses. Read More

View Article

Download full-text PDF

Source
https://erc.bioscientifica.com/view/journals/erc/26/2/ERC-18
Publisher Site
http://dx.doi.org/10.1530/ERC-18-0258DOI Listing
February 2019
1 Read

Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy.

Environ Int 2018 Dec 14;123:318-324. Epub 2018 Dec 14.

Department of Growth and Reproduction and EDMaRC, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.

Background: Biobank serum samples from longitudinal mother-child cohorts have been used to estimate prenatal exposures to endocrine disrupting chemicals (EDCs). However, the knowledge about variations in serum concentrations of non-persistent chemicals during pregnancy is limited.

Objective: To describe the within- and between-person variations in serum concentrations of non-persistent chemicals and changes over trimesters, including phthalate metabolites, parabens, phenols, and UV filters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2018.11.047DOI Listing
December 2018

Vertical profiles and distributions of aqueous endocrine-disrupting chemicals in different matrices from the Pearl River Delta and the influence of environmental factors.

Environ Pollut 2018 Dec 7;246:328-335. Epub 2018 Dec 7.

State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China.

The occurrence and distributions of selected endocrine-disrupting chemicals (EDCs), along with related environmental factors, were investigated in two rivers and six reservoirs in the Pearl River Delta. The vertical profiles of aqueous 4-tert-octylphenol (OP), 4-nonylphenol (NP), and estrone (E1) were constant, with little change in concentration between the surface and the river bottom, while higher aqueous concentrations of bisphenol A (BPA) were found in the bottom layers of the rivers. OP and NP in suspended particulate matter (SPM) were transferred from the surface to the bed layer, ultimately accumulating in the sediment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2018.12.015DOI Listing
December 2018

In utero exposure to bisphenol A disrupts fetal testis development in rats.

Environ Pollut 2018 Dec 7;246:217-224. Epub 2018 Dec 7.

Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, Zhejiang, 325027, China. Electronic address:

Bisphenol A (BPA) is widely used in consumer products and is a potential endocrine disruptor linked with abnormal development of male reproductive tract. However, its action and its effects on the pathways in the development of male gonad are still unclear. Here we report that effects of BPA exposure during gestation on male gonad development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2018.12.006DOI Listing
December 2018
4.143 Impact Factor

Distribution of endocrine-disrupting chemicals in colloidal and soluble phases in municipal secondary effluents and their removal by different advanced treatment processes.

Chemosphere 2018 Dec 4;219:730-739. Epub 2018 Dec 4.

State Key Laboratory of Pollution Control and Resource Reuse, Center for Hydrosciences Research, School of the Environment, Nanjing University, Nanjing, PR China.

In this work, the partition of endocrine-disrupting chemicals (EDCs) in colloid-bound and truly dissolved phases in municipal wastewater before and after advanced treatment processes was determined. The effluents, which were filtered using a 0.45 μm membrane, were further separated with the 1 kDa cross-flow ultrafiltration system into two phases, namely, colloidal phase (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2018.11.201DOI Listing
December 2018

Mechanism and kinetics studies of the atmospheric oxidation of p,p'-Dicofol by OH and NO radicals.

Chemosphere 2018 Dec 10;219:645-654. Epub 2018 Dec 10.

Environment Research Institute, Shandong University, Jinan, 250100, China.

As an effective organochlorine pesticide, Dicofol has been extensively applied in more than 30 countries for protecting over 60 different crops. Considering its large consumption and potential adverse effect on human health (endocrine disrupting and carcinogenicity), the fate of Dicofol sprayed into the air is of public concern. In this study, we conducted a comprehensive study on the reaction mechanisms of p,p'-Dicofol with OH and NO radicals using DFT method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2018.12.048DOI Listing
December 2018

The Acute Influence of Acid Suppression with Esomeprazole on Gastrointestinal Microbiota and Brain Gene Expression Profiles in a Murine Model of Restraint Stress.

Neuroscience 2018 Dec 14. Epub 2018 Dec 14.

Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, B168 12700 E. 19th Avenue, Aurora, CO 80045, USA. Electronic address:

The central nervous system (CNS) and gastrointestinal tract (GIT) are linked through neuro-endocrine and humoral pathways. Critically ill patients suffer severe physical and emotional stress and frequently receive acid suppressants; however, stress and acid suppression may alter GIT microbiota. This study evaluated the effects of acid suppression on the GIT microbiota and genome-wide expression of brain-specific genes in a murine model of restraint stress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2018.11.048DOI Listing
December 2018

Recombinant growth hormone therapy for cystic fibrosis in children and young adults.

Cochrane Database Syst Rev 2018 Dec 17;12:CD008901. Epub 2018 Dec 17.

Division of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, 630 West 168th St., New York, NY, USA, 10032.

Background: Cystic fibrosis (CF) is an inherited condition causing disease most noticeably in the lungs, digestive tract and pancreas. People with CF often have malnutrition and growth delay. Adequate nutritional supplementation does not improve growth optimally and hence an anabolic agent, recombinant human growth hormone (rhGH), has been proposed as a potential intervention. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/14651858.CD008901.pub4
Publisher Site
http://dx.doi.org/10.1002/14651858.CD008901.pub4DOI Listing
December 2018
1 Read

Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.

PLoS One 2018 17;13(12):e0208998. Epub 2018 Dec 17.

Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca Gothenburg, Mölndal, Sweden.

Aims/hypothesis: GPR44 (DP2, PTGDR2, CRTh2) is the receptor for the pro-inflammatory mediator prostaglandin D2 (PGD2) and it is enriched in human islets. In rodent islets, PGD2 is produced in response to glucose, suggesting that the PGD2-GPR44/DP2 axis may play a role in human islet function during hyperglycemia. Consequently, the aim of this work was to elucidate the insulinotropic role of GPR44 antagonism in vitro in human beta-cells and in type 2 diabetes (T2DM) patients. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208998PLOS
December 2018

Adjuvant endocrine therapy side-effects among postmenopausal breast cancer patients in Malaysia.

Climacteric 2018 Dec 17:1-7. Epub 2018 Dec 17.

a Faculty of Pharmacy , Universiti Kebangsaan Malaysia , Kuala Lumpur , Malaysia.

Objective: This study was conducted to determine the prevalence and severity of menopausal symptoms and their associated risk factors among postmenopausal breast cancer patients receiving adjuvant endocrine therapy.

Methods: Postmenopausal breast cancer patients on endocrine therapy were recruited at three hospitals in Malaysia. Presence and severity of menopausal symptoms were determined using the Menopause Rating Scale. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13697137.2018.1540563DOI Listing
December 2018

Meeting Report: 2018 Annual Meeting of the Pediatric Endocrine Society, Toronto, Canada, May 5-8, 2018, Selected Highlights.

Pediatr Endocrinol Rev 2018 Dec;16(2):284-293

Children's Hospital Los Angeles, 4650 Sunset Blvd, MS #61, Los Angeles, CA 90027, USA, E-mail:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17458/per.vol16.2018.lama.mr.pestorontoDOI Listing
December 2018

Narcolepsy, Precocious Puberty and Obesity in the Pediatric Population: a Literature Review.

Pediatr Endocrinol Rev 2018 Dec;16(2):266-274

Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil, E-mail:

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis and hypnagogic and hypnopompic hallucinations. The onset of the symptoms usually occurs in childhood, and previous studies have reported an association between narcolepsy and other endocrine diseases in the pediatric population, such as obesity and precocious puberty. The incidence of overweight or obesity ranges from 25% to 74% in patients with narcolepsy type I, while precocious puberty is present in 17% of children with narcolepsy with cataplexy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17458/per.vol16.2018.NarcolepsypubertyobesityDOI Listing
December 2018

Cardiometabolic risks in PCOS: a review of the current state of knowledge.

Expert Rev Endocrinol Metab 2018 Dec 4:1-11. Epub 2018 Dec 4.

a Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine , Monash University , Melbourne , Australia.

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 18% women of reproductive age. It is associated with a range of metabolic, reproductive, and psychological features. Current evidence indicates a role of PCOS in the development of metabolic and increased cardiovascular risk factors (CVRF) with implications for compromised cardiovascular endpoint disease, which may have a considerable impact on health and health care costs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17446651.2019.1556094DOI Listing
December 2018

Follicular dynamics and changes in estradiol-17β, progesterone and LH profiles following PGF induced estrus in early and late ovulating Beetal goats.

Reprod Domest Anim 2018 Dec 17. Epub 2018 Dec 17.

Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, 54000, Pakistan.

This study compares the factors associated with variable interval to estrus and ovulation between early vs. late ovulating goats following PGF administration. The extent of ovulation time in Beetal goats (n = 38) was monitored through transrectal ultrasound at every 6 h following a single dose of PGF  (experiment 1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/rda.13392DOI Listing
December 2018

Prevalence of growth and endocrine disorders in Malaysian children with transfusion-dependent thalassaemia.

Singapore Med J 2018 Dec 17. Epub 2018 Dec 17.

Department of Paediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.

Introduction: Endocrine dysfunction due to iron overload secondary to frequent blood transfusions is a common complication in children with transfusion-dependent thalassaemia (TDT). We ascertained the prevalence of endocrine dysfunction in children with TDT seen in a hospital setting in Malaysia.

Methods: We reviewed all patients with TDT who had ≥ 8 blood transfusions per year. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11622/smedj.2018155DOI Listing
December 2018

An update on the genetics of benign pituitary adenomas in children and adolescents.

Curr Opin Endocr Metab Res 2018 Aug 24;1:19-24. Epub 2018 Apr 24.

Section on Endocrinology & Genetics (SEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.

Pituitary adenomas in children and adolescents are rare tumors that often result from a tumor predisposition syndrome. Several inherited causes for pituitary adenomas have been identified in the last few years, including multiple endocrine neoplasia type 1 and 4, Carney's complex, Tuberous sclerosis, DICER1 syndrome, neurofibromatosis type 1, McCune Albright syndrome, familial isolated pituitary adenoma, and pituitary adenoma association due to defects in succinate dehydrogenase genes. Recently, our group discovered X-linked acrogigantism (X-LAG), a new pediatric disorder that is caused by an Xq26. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coemr.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289528PMC

Relatively high rate of postpartum thyroiditis in the Straits of Messina area. Predictivity of both postpartum thyroiditis and permanent hypothyroidism by performing, in the first trimester of gestation, thyroid ultrasonography and measurement of serum thyroperoxidase and thyroglobulin autoantibodies.

J Clin Transl Endocrinol 2019 Mar 23;15:12-18. Epub 2018 Nov 23.

Endocrinology, ASL, Reggio Calabria, Italy.

The prevalence of postpartum thyroiditis (PPT) averages 5%, with a range from 1% (Thailand) to 22% (Wales, UK, and Liguria, Italy), but 3.6% in another Italian region (Puglia). Evolution of PPT into permanent hypothyroidism (PH) occurs in approximately 50% of cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcte.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275208PMC

Using a cross-contextual reciprocal learning approach in a multisite implementation research project to improve self-management for type 2 diabetes.

BMJ Glob Health 2018 26;3(6):e001068. Epub 2018 Nov 26.

Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.

This paper reports on the use of reciprocal learning for identifying, adopting and adapting a type 2 diabetes self-management support intervention in a multisite implementation trial conducted in a rural setting in a low-income country (Uganda), a periurban township in a middle-income country (South Africa) and socioeconomically disadvantaged suburbs in a high-income country (Sweden). The learning process was guided by a framework for knowledge translation and structured into three learning cycles, allowing for a balance between evidence, stakeholder interaction and contextual adaptation. Key factors included commitment, common goals, leadership and partnerships. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjgh-2018-001068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267315PMC
November 2018

DNA damage repair defects as a new class of endocrine treatment resistance driver.

Oncotarget 2018 Nov 20;9(91):36252-36253. Epub 2018 Nov 20.

Svasti Haricharan: Department of Tumor Microenvironment and Cancer Immunology, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.26363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284739PMC
November 2018

Segmental Maternal UPD of Chromosome 7q in a Patient With Pendred and Silver Russell Syndromes-Like Features.

Front Genet 2018 30;9:600. Epub 2018 Nov 30.

Division of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Research, IRCCS Istituto Auxologico Italiano, Milan, Italy.

Pendred syndrome (PS) is an autosomal recessive disorder due to mutations in the gene (chr7q22. 3) and characterized by sensorineural hearing loss and variable thyroid phenotype. Silver-Russell syndrome (SRS) is a heterogeneous imprinting disorder including severe intrauterine and postnatal growth retardation, and dysmorphic features. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2018.00600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284021PMC
November 2018

Thyroid Disorders Change the Pattern of Response of Angiotensinase Activities in the Hypothalamus-Pituitary-Adrenal Axis of Male Rats.

Front Endocrinol (Lausanne) 2018 30;9:731. Epub 2018 Nov 30.

Department of Health Sciences, University of Jaén, Jaén, Spain.

Thyroid disorders affect the hypothalamic-pituitary-adrenal axis with important consequences on the cardiovascular function in which the renin-angiotensin system plays a major role. Hypo and hyperthyroidism influence the classic main components of the renin-angiotensin system. However, the behavior of other elements of the renin-angiotensin system such as Ang III, Ang 2-10, Ang IV, or AT, regulated by angiotensinase enzymes such as alanyl- (AlaAP), cystinyl- (CysAP), glutamyl- (GluAP), or aspartyl-aminopeptidase (AspAP), has not yet been described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2018.00731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283893PMC
November 2018

and Thyroid: A Pleiotropic Candidate Gene for Congenital Hypothyroidism.

Front Endocrinol (Lausanne) 2018 29;9:730. Epub 2018 Nov 29.

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Variations in the transcription factor Gli-similar 3 () gene have been associated to variable congenital endocrine defects, including both morphogenetic and functional thyroid alterations. Evidence from Glis3 knockout mice indicates a relevant role for in thyroid hormone biosynthesis and postnatal thyroid gland growth, with a mechanism of action downstream of the TSH/TSHR interaction. However, the pathophysiological role of this transcription factor during the embryonic thyroid development remains unexplored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2018.00730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281699PMC
November 2018

HDL in Endocrine Carcinomas: Biomarker, Drug Carrier, and Potential Therapeutic.

Front Endocrinol (Lausanne) 2018 30;9:715. Epub 2018 Nov 30.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, United States.

High-density lipoprotein (HDL) have long been studied for their protective role against cardiovascular diseases, however recently relationship between HDL and cancer came into focus. Several epidemiological studies have shown an inverse correlation between HDL-cholesterol (HDL-C) and cancer risk, and some have even implied that HDL-C can be used as a predictive measure for survival prognosis in for specific sub-population of certain types of cancer. HDL itself is an endogenous nanoparticle capable of removing excess cholesterol from the periphery and returning it to the liver for excretion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2018.00715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283888PMC
November 2018

Association Analysis of NLRP3 Inflammation-Related Gene Promotor Methylation as Well as Mediating Effects on T2DM and Vascular Complications in a Southern Han Chinese Population.

Front Endocrinol (Lausanne) 2018 29;9:709. Epub 2018 Nov 29.

Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.

To explore the association between the methylation levels in the promoter regions of the NLRP3, AIM2, and ASC genes and T2DM and its vascular complications in a Southern Han Chinese population and further analyze their interaction and mediating effects with environmental factors in T2DM. A case-control study was used to determine the association between population characteristics, the methylation level in the promoter region of the NLRP3, AIM2, and ASC genes and T2DM and vascular complications. A mediating effect among genes-environment-T2DM and the interaction of gene-gene or gene-environment factors was explored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2018.00709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281743PMC
November 2018

A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features.

Front Physiol 2018 30;9:1693. Epub 2018 Nov 30.

Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Body composition (BC) is an emerging important factor for the characterization of metabolic status. The assessment of BC has been studied in various populations and diseases such as obesity, diabetes, endocrine diseases as well as physiological and paraphysiological conditions such as growth and aging processes, and physical training. A gold standard technique for the assessment of human BC at molecular level is represented by dual-energy X-ray absorptiometry (DXA), which is able to precisely assess the body mass (and areal bone mineral density-aBMD) on a regional and whole-body basis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2018.01693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283977PMC
November 2018

Exposure to Atrazine Disrupts Rat Fetal Testis Development.

Front Pharmacol 2018 28;9:1391. Epub 2018 Nov 28.

Department of Anesthesiology, Perioperative and Pain Medicine, Key Laboratory of Anesthesiology of Zhejiang Province, Zhejiang, China.

Atrazine (ATR) is a commonly used agricultural herbicide and a potential endocrine disruptor that may cause testicular dysgenesis. The objective of the present study was to investigate the effects of atrazine on fetal testis development after exposure. Female Sprague-Dawley rats were gavaged daily with vehicle (corn oil, control) or atrazine (25, 50, and 100 mg/kg body weight/day) from gestational day 12 to 21. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2018.01391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280720PMC
November 2018

The oral selective oestrogen receptor degrader (SERD) AZD9496 is comparable to fulvestrant in antagonising ER and circumventing endocrine resistance.

Br J Cancer 2018 Dec 17. Epub 2018 Dec 17.

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, 77030, USA.

Background: The oestrogen receptor (ER) is an important therapeutic target in ER-positive (ER+) breast cancer. The selective ER degrader (SERD), fulvestrant, is effective in patients with metastatic breast cancer, but its intramuscular route of administration and low bioavailability are major clinical limitations.

Methods: Here, we studied the pharmacology of a new oral SERD, AZD9496, in a panel of in vitro and in vivo endocrine-sensitive and -resistant breast cancer models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41416-018-0354-9DOI Listing
December 2018

Impact of variants on type-2 diabetes risk genes identified through genomewide association studies in polycystic ovary syndrome: a case-control study.

J Genet 2018 Dec;97(5):1213-1223

Prince Fahd Bin Sultan Research Chair, Using Advance Technology for Diseases Detection and Treatment, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in females, and is associated with altered metabolic processes in particular insulin resistance and diabetes mellitus. PCOS shares with type-2 diabetes (T2D) a number of features, including beta cell dysfunction, impaired glucose tolerance and dyslipidaemia. Recently, genomewide association studies (GWAS) have reported a number of genes with reproducible associations and susceptibilities to T2D. Read More

View Article

Download full-text PDF

Source
December 2018

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.

Authors:
Nasim Mavaddat Kyriaki Michailidou Joe Dennis Michael Lush Laura Fachal Andrew Lee Jonathan P Tyrer Ting-Huei Chen Qin Wang Manjeet K Bolla Xin Yang Muriel A Adank Thomas Ahearn Kristiina Aittomäki Jamie Allen Irene L Andrulis Hoda Anton-Culver Natalia N Antonenkova Volker Arndt Kristan J Aronson Paul L Auer Päivi Auvinen Myrto Barrdahl Laura E Beane Freeman Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia V Bogdanova Stig E Bojesen Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Michael Bremer Hermann Brenner Adam Brentnall Ian W Brock Angela Brooks-Wilson Sara Y Brucker Thomas Brüning Barbara Burwinkel Daniele Campa Brian D Carter Jose E Castelao Stephen J Chanock Rowan Chlebowski Hans Christiansen Christine L Clarke J Margriet Collée Emilie Cordina-Duverger Sten Cornelissen Fergus J Couch Angela Cox Simon S Cross Kamila Czene Mary B Daly Peter Devilee Thilo Dörk Isabel Dos-Santos-Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana M Eccles Arif B Ekici A Heather Eliassen Carolina Ellberg Christoph Engel Mikael Eriksson D Gareth Evans Peter A Fasching Jonine Figueroa Olivia Fletcher Henrik Flyger Asta Försti Lin Fritschi Marike Gabrielson Manuela Gago-Dominguez Susan M Gapstur José A García-Sáenz Mia M Gaudet Vassilios Georgoulias Graham G Giles Irina R Gilyazova Gord Glendon Mark S Goldberg David E Goldgar Anna González-Neira Grethe I Grenaker Alnæs Mervi Grip Jacek Gronwald Anne Grundy Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A Haiman Niclas Håkansson Ute Hamann Susan E Hankinson Elaine F Harkness Steven N Hart Wei He Alexander Hein Jane Heyworth Peter Hillemanns Antoinette Hollestelle Maartje J Hooning Robert N Hoover John L Hopper Anthony Howell Guanmengqian Huang Keith Humphreys David J Hunter Milena Jakimovska Anna Jakubowska Wolfgang Janni Esther M John Nichola Johnson Michael E Jones Arja Jukkola-Vuorinen Audrey Jung Rudolf Kaaks Katarzyna Kaczmarek Vesa Kataja Renske Keeman Michael J Kerin Elza Khusnutdinova Johanna I Kiiski Julia A Knight Yon-Dschun Ko Veli-Matti Kosma Stella Koutros Vessela N Kristensen Ute Krüger Tabea Kühl Diether Lambrechts Loic Le Marchand Eunjung Lee Flavio Lejbkowicz Jenna Lilyquist Annika Lindblom Sara Lindström Jolanta Lissowska Wing-Yee Lo Sibylle Loibl Jirong Long Jan Lubiński Michael P Lux Robert J MacInnis Tom Maishman Enes Makalic Ivana Maleva Kostovska Arto Mannermaa Siranoush Manoukian Sara Margolin John W M Martens Maria Elena Martinez Dimitrios Mavroudis Catriona McLean Alfons Meindl Usha Menon Pooja Middha Nicola Miller Fernando Moreno Anna Marie Mulligan Claire Mulot Victor M Muñoz-Garzon Susan L Neuhausen Heli Nevanlinna Patrick Neven William G Newman Sune F Nielsen Børge G Nordestgaard Aaron Norman Kenneth Offit Janet E Olson Håkan Olsson Nick Orr V Shane Pankratz Tjoung-Won Park-Simon Jose I A Perez Clara Pérez-Barrios Paolo Peterlongo Julian Peto Mila Pinchev Dijana Plaseska-Karanfilska Eric C Polley Ross Prentice Nadege Presneau Darya Prokofyeva Kristen Purrington Katri Pylkäs Brigitte Rack Paolo Radice Rohini Rau-Murthy Gad Rennert Hedy S Rennert Valerie Rhenius Mark Robson Atocha Romero Kathryn J Ruddy Matthias Ruebner Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Daniel F Schmidt Rita K Schmutzler Andreas Schneeweiss Minouk J Schoemaker Fredrick Schumacher Peter Schürmann Lukas Schwentner Christopher Scott Rodney J Scott Caroline Seynaeve Mitul Shah Mark E Sherman Martha J Shrubsole Xiao-Ou Shu Susan Slager Ann Smeets Christof Sohn Penny Soucy Melissa C Southey John J Spinelli Christa Stegmaier Jennifer Stone Anthony J Swerdlow Rulla M Tamimi William J Tapper Jack A Taylor Mary Beth Terry Kathrin Thöne Rob A E M Tollenaar Ian Tomlinson Thérèse Truong Maria Tzardi Hans-Ulrich Ulmer Michael Untch Celine M Vachon Elke M van Veen Joseph Vijai Clarice R Weinberg Camilla Wendt Alice S Whittemore Hans Wildiers Walter Willett Robert Winqvist Alicja Wolk Xiaohong R Yang Drakoulis Yannoukakos Yan Zhang Wei Zheng Argyrios Ziogas Alison M Dunning Deborah J Thompson Georgia Chenevix-Trench Jenny Chang-Claude Marjanka K Schmidt Per Hall Roger L Milne Paul D P Pharoah Antonis C Antoniou Nilanjan Chatterjee Peter Kraft Montserrat García-Closas Jacques Simard Douglas F Easton

Am J Hum Genet 2018 Dec 5. Epub 2018 Dec 5.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.

Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00029297183040
Publisher Site
http://dx.doi.org/10.1016/j.ajhg.2018.11.002DOI Listing
December 2018
1 Read

Advanced age does not increase morbidity after total thyroidectomy. Result of a prospective study.

Am J Surg 2018 Nov 27. Epub 2018 Nov 27.

Department of Endocrine Surgery, King Georges' Medical University, Lucknow, UP, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjsurg.2018.11.013DOI Listing
November 2018

Scutellarin Suppresses Platelet Aggregation and Stalls Lesional Progression in Mouse With Induced Endometriosis.

Reprod Sci 2018 Dec 17:1933719118817661. Epub 2018 Dec 17.

1 Shanghai OB/GYN Hospital, Fudan University, Shanghai, China.

Platelets play an important role in the development of endometriosis. Scutellarin is a flavonoid isolated from a medicinal herb traditionally used as a potent antiplatelet agent. In this study, we sought to evaluate its potential therapeutic effect, if any, in mice with induced endometriosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719118817661DOI Listing
December 2018

Efficacy of calcium excretion and calcium/creatinine clearance ratio in the differential diagnosis of familial hypocalciuric hypercalcemia and primary hyperparathyroidism.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.

Background: Twenty-four-hour renal calcium-excretion (CE) and calcium/creatinine-clearance-ratio (CCCR), respectively, are widely used to rule out familial hypocalciuric hypercalcemia (FHH) in patients with suspected primary hyperparathyroidism before surgery. The aim was to evaluate the practicability of CE compared to CCCR.

Patients And Methods: We analyzed biochemical parameters, surgical treatment, gene mutation results, and long-term follow-up data of 198 patients (including 14 patients with FHH) and the discriminative power of CE and CCCR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.25568DOI Listing
December 2018

Skeletal fragility: an emerging complication of Ehlers-Danlos syndrome.

Endocrine 2018 Dec 15. Epub 2018 Dec 15.

Vita-Salute San Raffaele University, Milano, Italy.

Ehlers-Danlos syndrome (EDS) is an emerging cause of skeletal fragility. Mechanism of bone damage are probably multifactorial in line with the different skeletal phenotypes that can be found in clinical practice. A structured approach to clinical management of bone metabolic complication in EDS is proposed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-018-1822-yDOI Listing
December 2018

A Family with Autosomal Dominant Distal Renal Tubular Acidosis Presents with Atypical Phenotype Caused by a Missence Mutation (R388C) of the Human Kidney Anion Exchanger.

Nephron 2018 Dec 14:1-6. Epub 2018 Dec 14.

Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang,

Hereditary forms of distal renal tubular acidosis (dRTA) are rare and mainly caused by mutations in ATP6V1B1, ATP6V0A4 and SLC4A1. About 20 mutations in SLC4A1 gene have been found that are related to either autosomal dominant (AD) or autosomal recessive dRTA. AD dRTA often manifest as constitutional and can easily be delayed in diagnosis and treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495763DOI Listing
December 2018

Testicular morphology and spermatogenesis in harbour porpoises (Phocoena phocoena).

Theriogenology 2018 Nov 28;126:177-186. Epub 2018 Nov 28.

Institute for Anatomy, University of Veterinary Medicine Hanover Foundation, Bischofsholer Damm 15, 30173, Hanover, Germany. Electronic address:

Knowledge about reproductive parameters in male harbour porpoises such as testicular histology and germ cell maturation as well as seasonal changes in spermatogenesis is scarce. Thus, the aim of the present study was to report changes in the histological appearance of the testicular morphology of neonatal and juvenile harbour porpoises during maturation, to identify stages of spermatogenesis in adult males and to detect seasonal modifications. The identification of these stages can be used to assess the developmental profile of gene expression during spermatogenesis and to identify defects in spermatogenesis arising in pathological conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.theriogenology.2018.11.031DOI Listing
November 2018

Molecular characterization and juvenile hormone-regulated transcription of the vitellogenin receptor in the cabbage beetle Colaphellus bowringi.

Comp Biochem Physiol A Mol Integr Physiol 2018 Dec 13;229:69-75. Epub 2018 Dec 13.

Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

The vitellogenin receptor (VgR) is highly expressed in the ovaries where it is responsible for vitellogenin (Vg) deposition during oogenesis in insects. Therefore, identifying the VgR of insect pests, and understanding the mechanism regulating its expression, could lead to the development of pest management strategies based on disrupting reproduction. We cloned and identified VgR in the cabbage beetle, Colaphellus bowringi, which is a serious pest of cruciferous vegetables in Asia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbpa.2018.12.004DOI Listing
December 2018

Comparative estrogenicity of endogenous, environmental and dietary estrogens in pregnant women II: Total estrogenicity calculations accounting for competitive protein and receptor binding and potency.

Food Chem Toxicol 2018 Dec 13. Epub 2018 Dec 13.

Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA, 99352, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 93771, USA. Electronic address:

Evaluating the biological significance of human-relevant exposures to environmental estrogens involves assessing the individual and total estrogenicity of endogenous and exogenous estrogens found in serum, for example from biomonitoring studies. We developed a method for this assessment by integrating approaches for (i) measuring total hormone concentrations by mass spectrometry (Fleck et al., 2017), (ii) calculating hormone bioavailable concentrations in serum and, (iii) solving multiple equilibria between estrogenic ligands and receptors, and (iv) quantitatively describing key elements of estrogen potency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fct.2018.12.013DOI Listing
December 2018

Higher symptom burden is associated with lower function in women taking adjuvant endocrine therapy for breast cancer.

J Geriatr Oncol 2018 Dec 12. Epub 2018 Dec 12.

Medical Oncology, Duke University Medical Center, Durham, NC 27710, United States. Electronic address:

Objective: To explore the impact of symptoms on physical function in women on adjuvant endocrine therapy for breast cancer.

Methods: Eligible women were postmenopausal, had hormone receptor positive, stage I-IIIA breast cancer, completed surgery, chemotherapy, radiation, and on adjuvant endocrine therapy. At a routine follow-up visit, women (N = 107) completed standardized symptom measures: Brief Fatigue Inventory, Brief Pain Inventory, Menopause Specific Quality of Life Questionnaire, Functional Assessment of Cancer Therapy Neurotoxicity scales. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jgo.2018.11.008DOI Listing
December 2018

Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study.

Environ Int 2018 Dec 12. Epub 2018 Dec 12.

Unit of Molecular Epidemiology and Genetics in Infections and Cancer, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

Background: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health.

Objectives: We investigated whether occupational exposure to alkylphenolic compounds is associated with breast and prostate cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2018.12.007DOI Listing
December 2018

Developmental toxicity of kresoxim-methyl during zebrafish (Danio rerio) larval development.

Chemosphere 2018 Dec 8;219:517-525. Epub 2018 Dec 8.

Institute of Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences, State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Hangzhou, 310021, Zhejiang, China. Electronic address:

Kresoxim-methyl (KM) is a broad spectrum strobilurin fungicide that has been used widely on crops around the world. In the present study, we aimed to investigate the toxic effects of KM using various sublethal endpoints during zebrafish (Danio rerio) larval development. Results showed that the LC values of KM to zebrafish at multiple life stages (embryo, larvae, juvenile and adult) were 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2018.12.061DOI Listing
December 2018
1 Read

Urinary levels of bisphenol A, F and S and markers of oxidative stress among healthy adult men: Variability and association analysis.

Environ Int 2018 Dec 12;123:301-309. Epub 2018 Dec 12.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as alternatives to endocrine disrupting chemical bisphenol A (BPA). Evidence from in vitro and animal studies demonstrates that BPA, BPF and BPS induce oxidative stress, a proposed mechanism that is relevant to various adverse health effects. Evaluation in humans is hampered by the potentially high within-subject variability of urinary measurements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2018.11.071DOI Listing
December 2018

A comparative effectiveness study of degludec and insulin glargine 300U/mL in insulin-naïve patients with type 2 diabetes.

Diabetes Obes Metab 2018 Dec 15. Epub 2018 Dec 15.

Clinical Research, Endocrine and Metabolic Consultants, Rockville, MD, USA.

Aims: To compare the real-world effectiveness of insulin degludec (degludec) and glargine 300 units/mL (glargine U300) in insulin-naïve adult patients with type 2 diabetes in routine US clinical practice.

Materials And Methods: CONFIRM is a non-interventional comparative effectiveness study following US patients across the continuum of care, through electronic medical records from multiple health systems and integrated delivery networks. Propensity-score matching controlled for confounding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dom.13616DOI Listing
December 2018
1 Read

Calcitriol loading before total parathyroidectomy with autotransplant in patients with end stage kidney disease: Does it prevent postoperative hypocalcaemia?

Intern Med J 2018 Dec 15. Epub 2018 Dec 15.

Endocrine and General Surgery, Department of Surgery, John Hunter Hospital and Newcastle Private Hospital, Lookout Road New Lambton Heights, New South Wales, Australia, 2305.

Background: Hungry bone syndrome (HBS) is one of the most serious complications following parathyroidectomy for severe hyperparathyroidism. There is a lack of literature informing the treatment and risk factors for this condition and the ideal pre-operative strategy for prevention.

Aims: The primary aims of this study were to examine the incidence of HBS with pre-operative calcitriol loading for 10 days and to determine the risk factors for HBS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imj.14209DOI Listing
December 2018
1 Read

Remission of hyperglycemia in spontaneously diabetic NOD mice upon transplant of microencapsulated human umbilical cord Wharton jelly-derived mesenchymal stem cells (hUCMS).

Xenotransplantation 2018 Dec 15:e12476. Epub 2018 Dec 15.

Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology, and Laboratory for Endocrine Cell Transplants and Biohybrid Organs, Department of Medicine, University of Perugia, Perugia, Italy.

Background: Our previous in vitro demonstration of the immunoregulatory effects of microencapsulated hUCMS on human peripheral blood mononuclear cells (PBMCs) extracted from patients with recent onset, type 1 diabetes mellitus (DM), prompted us to test our product for xenograft (TX) in non obese diabetic (NOD) mice with spontaneous DM.

Methods: We transplanted microencapsulated hUCMS into the peritoneal cavity of NOD mice with either severe or mild DM. Blood glucose (BG) levels were monitored following TX, in either basal or upon glucose stimulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/xen.12476DOI Listing
December 2018

Protracted Glycosuria after Discontinuation of SGLT2 Inhibitors: Implications for Weekly Dosing and Extended Risk of Euglycemic Diabetes Ketoacidosis.

J Diabetes 2018 Dec 15. Epub 2018 Dec 15.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1753-0407.12885DOI Listing
December 2018
1 Read

Extracorporeal shock wave lithotripsy is safe and effective for geriatric patients with chronic pancreatitis.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, The Second Military Medical University, Shanghai, China.

Background & Aims: Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is first-line treatment for chronic pancreatitis (CP) patients with pancreatic stones. However, the performance of P-EWSL in geriatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for them. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14569DOI Listing
December 2018

Diagnostic pathways and management in women with pregnancy-associated breast cancer (PABC): no evidence of treatment delays following a first healthcare contact.

Breast Cancer Res Treat 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: Women with pregnancy-associated breast cancer (PABC), i.e. diagnosed during or within 2 years of pregnancy, have a poor prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-018-05083-xDOI Listing
December 2018

In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds.

Arch Toxicol 2018 Dec 14. Epub 2018 Dec 14.

BASF SE, Experimental Toxicology and Ecology, Carl Bosch Straße 38, 67056, Ludwigshafen, Germany.

While in vitro testing is used to identify hazards of chemicals, nominal in vitro assay concentrations may misrepresent potential in vivo effects and do not provide dose-response data which can be used for a risk assessment. We used reverse dosimetry to compare in vitro effect concentrations-to-in vivo doses causing toxic effects related to endocrine disruption. Ten compounds (acetaminophen, bisphenol A, caffeine, 17α-ethinylestradiol, fenarimol, flutamide, genistein, ketoconazole, methyltestosterone, and trenbolone) have been tested in the yeast estrogen screening (YES) or yeast androgen-screening (YAS) assays for estrogen and androgen receptor binding, as well as the H295R assay (OECD test guideline no. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00204-018-2372-zDOI Listing
December 2018

Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress-Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer.

Mol Cancer Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrine Neoplasia and Hormonal Disorders, MD Anderson Cancer Center.

Medullary thyroid carcinoma (MTC) originates from the C cells of the thyroid gland, which secrete calcitonin. Lymph node and distant metastases are frequently present at diagnosis. Activating mutations of RET, a driver oncogene in MTC that encodes a tyrosine kinase receptor, prevents apoptosis through inhibition of ATF4, a key transcriptional regulator of endoplasmic reticulum (ER) stress. Read More

View Article

Download full-text PDF

Source
http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
Publisher Site
http://dx.doi.org/10.1158/1541-7786.MCR-18-0354DOI Listing
December 2018
1 Read
  • Page 1 of 11068