553,086 results match your criteria Endocrine Research [Journal]


Genetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival.

Peptides 2018 Dec 8. Epub 2018 Dec 8.

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Road, CB 7545, Chapel Hill, NC, 27599, USA. Electronic address:

Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are small peptides derived from a common precursor, pre-proadrenomedullin. Although AM and PAMP share hypotensive effects in the cardiovascular system, the peptides also exert diverse and distinct effects on endocrine physiology, innate immunity, cytoskeletal biology and receptor signaling pathways. Tremendous knowledge has been gleaned from the study of several genetic animal models of AM deletion or overexpression, some of which also simultaneously delete the coding region for PAMP peptide. Read More

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December 2018

A randomized, multicentre trial evaluating the efficacy and safety of fast-acting insulin aspart in continuous subcutaneous insulin infusion in adults with type 1 diabetes (onset 5).

Diabetes Obes Metab 2018 Dec 9. Epub 2018 Dec 9.

Department of Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital Ljubljana, and Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Aims: To evaluate the efficacy and safety of fast-acting insulin aspart (faster aspart [FA]) vs insulin aspart (IAsp) in continuous subcutaneous insulin infusion (CSII) in participants with type 1 diabetes.

Materials And Methods: Double-blind, treat-to-target, randomized, 16-week trial investigating CSII treatment with FA (n = 236) or IAsp (n = 236). All available information regardless of treatment discontinuation was used for the evaluation of effect. Read More

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December 2018

Adult type rhabdomyoma presenting as a parathyroid adenoma.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Adult-type rhabdomyoma (ATR) is a rare mesenchymal tumor of skeletal muscle differentiation. Extracardiac ATR occurs most commonly in the head and neck, but do so in a heterogeneous fashion, arising at numerous different locations within this region.

Methods: At our institution, we encountered a patient who was diagnosed clinically with parathyroid adenoma based on signs and symptoms of hyperparathyroidism and suggestive radiologic findings. Read More

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December 2018

Effects of inhibitors of the renin-angiotensin system on reducing blood pressure and expression of inflammatory factors in CHD patients: A network meta-analysis.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

First Cadres Ward, The First Affiliated Hospital of PLA General Hospital, Beijing, China.

The renin-angiotensin system (RAS) is an ever-evolving endocrine system with considerable checks and balances on the production and catabolism of angiotensin peptides most likely due to the manifold effects of angiotensins. We aimed to explore the effects of different inhibitors of RAS on blood pressure and expression of inflammatory factors in patients with coronary heart disease (CHD). We initially searched PubMed, EMBASE and Cochrane Library electronic databases with nine eligible randomized controlled trials enrolled. Read More

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December 2018
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Extent of lateral neck dissection for papillary thyroid microcarcinomas.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Thyroid and Endocrine Surgery Section, Department of Surgery, Gachon University College of Medicine, Gil Medical Center, Incheon, Republic of Korea.

Background: Papillary thyroid microcarcinomas (PTMCs) often demonstrate lateral lymph node (LN) metastasis. The purpose of this study was to assess whether the size of primary tumor should be considered in deciding lateral neck dissection extent.

Methods: We conducted a retrospective comparison of patients with PTMC and papillary thyroid carcinoma (PTC) larger than 1 cm who received lateral LN dissection from 2009 to 2015. Read More

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December 2018

Coenzyme Q protects against β-cell toxicity induced by pravastatin treatment of hypercholesterolemia.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.

New onset of diabetes is associated with the use of statins. We have recently demonstrated that pravastatin-treated hypercholesterolemic LDL receptor knockout (LDLr ) mice exhibit reductions in insulin secretion and increased islet cell death and oxidative stress. Here, we hypothesized that these diabetogenic effects of pravastatin could be counteracted by treatment with the antioxidant coenzyme Q (CoQ ), an intermediate generated in the cholesterol synthesis pathway. Read More

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December 2018

Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor-positive, advanced breast cancer: A real-world experience.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Data from 423 human epidermal growth factor receptor 2-negative (HER2-), hormone receptor-positive (HR+) advanced breast cancer (aBC) patients treated with palbociclib and endocrine therapy (ET) were provided by 35 Italian cancer centers and analyzed for treatment outcomes. Overall, 158 patients were treated in first line and 265 in second/later lines. We observed 19 complete responses and 112 partial responses. Read More

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December 2018
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Superior detection of metastatic cystic lymphadenopathy in patients with papillary thyroid cancer by utilization of thyroglobulin washout.

Head Neck 2018 Dec 9. Epub 2018 Dec 9.

Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

Background: Fine-needle aspiration (FNA) cytology has been the standard of care in the workup of cervical lymph nodes (LNs) in patients with recurrent papillary thyroid cancer (PTC) and suspicious cervical LNs. Recently, FNA thyroglobulin (TG) washout measurement has been proposed as an adjunct in the management of these patients. We hypothesize that using FNA-TG washout for suspicious cervical LNs would increase the accuracy of diagnosing metastatic disease especially in cystic and highly vascular cervical LN in patients with recurrent PTC. Read More

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December 2018

8:2 Fluorotelomer alcohol causes immunotoxicity and liver injury in adult male C57BL/6 mice.

Environ Toxicol 2018 Dec 7. Epub 2018 Dec 7.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.

8:2 Fluorotelomer alcohol (8:2 FTOH) is widely used in houseware and industrial goods and is ubiquitous in the surrounding environment. 8:2 FTOH has been linked to hepatoxicity, nephrotoxicity, and reproductive toxicity, as well as endocrine-disrupting effects. However, as of yet, the research regarding immunotoxicity of 8:2 FTOH remains largely limited. Read More

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December 2018
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Evolution of Our Understanding of the Hyperparathyroid Syndromes: A Historical Perspective.

J Bone Miner Res 2018 Dec 10. Epub 2018 Dec 10.

Calcium Research Laboratory, Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, Montreal, Canada.

We review advancing and overlapping stages for our understanding of the expressions of six hyperparathyroid (HPT) syndromes: multiple endocrine neoplasia type 1 (MEN1) or type 4, multiple endocrine neoplasia type 2A (MEN2A), hyperparathyroidism-jaw tumor syndrome, familial hypocalciuric hypercalcemia, neonatal severe primary hyperparathyroidism, and familial isolated hyperparathyroidism. During stage 1 (1903 to 1967), the introduction of robust measurement of serum calcium was a milestone that uncovered hypercalcemia as the first sign of dysfunction in many HPT subjects, and inheritability was reported in each syndrome. The earliest reports of HPT syndromes were biased toward severe or striking manifestations. Read More

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December 2018
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Completion Thyroidectomy: Revisited a Quarter of a Century Later.

Ann Surg Oncol 2018 Dec 7. Epub 2018 Dec 7.

Department of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, USA.

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December 2018

Thyroidectomy Then and Now: A 50-Year Australian Perspective.

World J Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of General Surgery, Monash University Endocrine Surgery Unit, The Alfred Hospital, 55 Commercial Rd, Melbourne, VIC, 3004, Australia.

Background: Since the mid-1800s, thyroidectomy has transformed from a procedure associated with high to near-zero mortality. Nonetheless, surgeons must continue to strive to improve patient care. Using historical records and contemporary data, this study compares the practice and outcomes of thyroid surgery at a tertiary institution during two periods, 50 years apart. Read More

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December 2018
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Liraglutide induces beige fat development and promotes mitochondrial function in diet induced obesity mice partially through AMPK-SIRT-1-PGC1-α cell signaling pathway.

Endocrine 2018 Dec 9. Epub 2018 Dec 9.

Department of Physician Assistant, College of Health Professions, Central Michigan University MI, Mount Pleasant, MI, 48859, USA.

Purpose: Glucagon like peptide-1 (GLP-1) is produced to induce postprandial insulin secretion. Liraglutide, a full agonist of the GLP-1 receptor, has a protective effect on weight gain in obese subjects. Brown adipose tissue plays a major role in the control of energy balance and is known to be involved in the weight loss regulated by liraglutide. Read More

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December 2018

Monosodium Glutamate (MSG)-Induced Animal Model of Type 2 Diabetes.

Methods Mol Biol 2019 ;1916:49-65

Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

In 1976, an animal model of type 2 diabetes (T2DM) was described by Cameron et al. using injection of monosodium glutamate (MSG) in KK mice during the neonatal period. Some years later, similar models have been developed by various doses and durations and the main of these models exhibited obesity and features of diabetes mellitus, including glycosuria, hyperglycemia, hyperinsulinemia, decreased glucose tolerance, and insulin sensitivity. Read More

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January 2019

Adrenal myelolipoma in association with congenital adrenal hyperplasia.

Authors:
Hee Jin Kim

Endocrine 2018 Dec 8. Epub 2018 Dec 8.

Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Chungnam, Republic of Korea.

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December 2018

Pesticides and Related Toxicants in the Atmosphere.

Rev Environ Contam Toxicol 2018 Dec 8. Epub 2018 Dec 8.

Department of Environmental Toxicology, University of California, Davis, Davis, CA, USA.

Pesticides and other toxicants released into the environment can contaminate air, water, soil, and biota. This review focuses on sources, exposures, fate, analysis, and trends. The potential for exposures due to atmospheric transport and deposition of pesticides and related contaminants may pose risks to humans and wildlife. Read More

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December 2018

MicroRNA‑100‑5p inhibits osteoclastogenesis and bone resorption by regulating fibroblast growth factor 21.

Int J Mol Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopedic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.

MicroRNAs (miRNAs/miRs) are post‑transcriptional regulators that serve important roles in osteoclastogenesis and bone metabolism; however, the roles of miRNAs have not been completely clarified. The present study aimed to investigate the effects of miR‑100‑5p on the mechanism of liver‑bone endocrine metabolism. A miRNA microarray analysis was conducted to evaluate the miRNA expression profile during receptor activator of nuclear factor‑κB ligand‑stimulated osteoclastogenesis. Read More

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December 2018

Delegating sex: differential gene expression in stolonizing syllids uncovers the hormonal control of reproduction.

Genome Biol Evol 2018 Dec 11. Epub 2018 Dec 11.

Department of Life Sciences, The Natural History Museum of London, Cromwell Road, London, United Kingdom.

Stolonization in syllid annelids is a unique mode of reproduction among animals. During the breeding season, a structure resembling the adult but containing only gametes, called stolon, is formed generally at the posterior end of the animal. When stolons mature, they detach from the adult and gametes are released into the water column. Read More

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December 2018

Hysterectomy uniquely impacts spatial memory in a rat model: A role for the non-pregnant uterus in cognitive processes.

Endocrinology 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology, Arizona State University, Tempe, AZ.

Approximately one-third of women experience hysterectomy, or the surgical removal of the uterus, by age 60, with most surgeries occurring prior to the onset of natural menopause. The ovaries are retained in about half of these surgeries while, for the other half, hysterectomy occurs concurrently with oophorectomy. The dogma is that the non-pregnant uterus is dormant. Read More

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December 2018

Comparison of denosumab vs. bisphosphonates in osteoporosis patients: A meta-analysis of randomized controlled trials.

J Clin Endocrinol Metab 2018 Dec 10. Epub 2018 Dec 10.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States.

Background: Among the currently available osteoporosis therapeutics, bisphosphonates and denosumab are widely used. However, it remains uncertain which therapy is more effective.

Objective: To determine whether the use of denosumab increases bone mineral density (BMD) and reduces the risk of fractures more than bisphosphonates in patients with low BMD or osteoporosis. Read More

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December 2018
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Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis: The J-DAVID Randomized Clinical Trial.

JAMA 2018 Dec;320(22):2325-2334

Hemodialysis Center, Inoue Hospital, Soryu Medical Corporation, Osaka, Japan.

Importance: Patients with chronic kidney disease have impaired vitamin D activation and elevated cardiovascular risk. Observational studies in patients treated with hemodialysis showed that the use of active vitamin D sterols was associated with lower risk of all-cause mortality, regardless of parathyroid hormone levels.

Objective: To determine whether vitamin D receptor activators reduce cardiovascular events and mortality in patients without secondary hyperparathyroidism undergoing hemodialysis. Read More

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December 2018

Advantages of Serum Anti-Müllerian Hormone as a Marker for Polycystic Ovarian Syndrome.

Lab Med 2018 Dec 10. Epub 2018 Dec 10.

Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Objective: To evaluate the advantages of using anti-Müllerian hormone (AMH) in the diagnosis of polycystic ovary syndrome (PCOS).

Methods: We compared data from 56 Han Chinese patients with PCOS and 52 female control Han Chinese individuals in terms of biochemical markers and the antral follicle count (AFC). Then, the correlation between serum AMH levels and various endocrine and metabolic factors was analyzed. Read More

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December 2018

Reproductive and Behavior Dysfunction Induced by Maternal Androgen Exposure and Obesity Is Likely Not Gut Microbiome-Mediated.

J Endocr Soc 2018 Dec 15;2(12):1363-1380. Epub 2018 Oct 15.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder of unclear etiology in women and is characterized by androgen excess, insulin resistance, and mood disorders. The gut microbiome is known to influence conditions closely related with PCOS, and several recent studies have observed changes in the stool microbiome of women with PCOS. The mechanism by which the gut microbiome interacts with PCOS is still unknown. Read More

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December 2018

The Bhubaneswar Declaration on Sports Endocrinology, 2018.

Indian J Endocrinol Metab 2018 Nov;22(Suppl 1):S14-S16

Department of Endocrinology, MP Shah Hospital, Nairobi, Kenya.

Sports and endocrinology are complex interrelated disciplines. Sports and exercise modulate endocrine and metabolic health, and are used to prevent and manage disease. Endocrine and metabolic function influence participation and performance in sports activity. Read More

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November 2018
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Nephrectomy for Metastatic Kidney Tumor in Patients with Differentiated Thyroid Cancer: A Report of Two Cases.

Case Rep Endocrinol 2018 11;2018:7842792. Epub 2018 Nov 11.

Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan.

The occurrence of renal tumors originating from thyroid cancer is extremely rare with a few effective treatments for renal metastases. Here, we report the cases of two patients with differentiated thyroid cancer who underwent nephrectomy for a metastatic kidney tumor. Case 1 was a 74-year-old man who was diagnosed with right kidney tumor 10 years after initial surgery for papillary thyroid cancer (PTC). Read More

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November 2018

Antidiabetic efficacy of lactoferrin in type 2 diabetic pediatrics; controlling impact on PPAR-γ, SIRT-1, and TLR4 downstream signaling pathway.

Diabetol Metab Syndr 2018 4;10:89. Epub 2018 Dec 4.

2Department of Clinical Pharmacy and Pharmacy Practice, Translational Research Unit, Faculty of Pharmacy, Misr International University, Cairo, Egypt.

The current study aims to investigate the antidiabetic efficacy of camel milk-derived lactoferrin and potential involvement of PPAR-γ and SIRT-1 via TLR-4/NFκB signaling pathway in obese diabetic pediatric population. Sixty young obese patients with type 2 diabetes were selected from the Pediatric Endocrine Metabolic Unit, Cairo University and were randomly divided among two age and sex-matched groups so as to receive either standard therapy without lactoferrin in one arm or to be treated with oral lactoferrin capsules (250 mg/day, p.o) for 3 months in the other arm. Read More

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December 2018

Understanding the Multitarget Pharmacological Mechanism of the Traditional Mongolian Common Herb Pair GuangZao-RouDouKou Acting on Coronary Heart Disease Based on a Bioinformatics Approach.

Evid Based Complement Alternat Med 2018 11;2018:7956503. Epub 2018 Nov 11.

School of Basic Medicine, Inner Mongolia Medical University, Huhehot, China.

GuangZao and RouDouKou ( and , FCN) are one of the most common herb pairs in traditional Mongolian medicine for the treatment of coronary heart disease (CHD). However, evidence for the protective effect of FCN is limited, and its underlying mechanism of action remains unclear. The present study employed a network pharmacology approach to identify the potentially active ingredients and synergistic effects of the herb pair FCN as traditional Mongolian medicine. Read More

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November 2018

A Large Substernal Goiter that Extended to Both Sides of the Thorax.

Case Rep Surg 2018 5;2018:6107982. Epub 2018 Nov 5.

Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.

Most substernal goiters can be managed through the transcervical approach, but a sternotomy is required in some cases. This report is about a large substernal goiter, which was resected via a transcervical and full sternotomy approach. The patient was a 57-year-old female, who visited our hospital for surgical treatment for a large substernal goiter. Read More

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November 2018

A clinically functioning gonadotroph adenoma presenting with abdominal pain, ovarian hyperstimulation and fibromatosis.

Endocrinol Diabetes Metab Case Rep 2018 Dec 11;2018. Epub 2018 Dec 11.

Southmead Hospital, North Bristol NHS Trust, Westbury-on-Trym, Bristol, UK.

Pituitary adenomas can be classified as functioning or non-functioning adenomas. Approximately 64% of clinically non-functioning pituitary adenomas are found to be gonadotroph adenomas on immunohistochemistry. There are reported cases of gonadotroph adenomas causing clinical symptoms, but this is unusual. Read More

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December 2018

Spontaneously remitting insulin autoimmune syndrome in a patient taking alpha-lipoic acid.

Endocrinol Diabetes Metab Case Rep 2018 Dec 11;2018. Epub 2018 Dec 11.

Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Insulin autoimmune syndrome (IAS), or Hirata disease, is a rare hypoglycaemic disorder caused by the presence of high titer of insulin autoantibodies (IAA) in patients without previous exposure to exogenous insulin. Even though its pathogenesis is not fully understood, striking evidences link IAS to previous exposure to sulphydryl-containing medications, like alpha-lipoic acid, a widely used nutritional supplement. Although challenging, a careful differential diagnosis from other causes of hyperinsulinaemic hypoglycaemia (such as insulinoma) is mandatory, since these conditions require different therapeutic approaches. Read More

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December 2018
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Relationship Between Circulating Netrin-1 Concentration, Impaired Fasting Glucose, and Newly Diagnosed Type 2 Diabetes.

Front Endocrinol (Lausanne) 2018 23;9:691. Epub 2018 Nov 23.

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.

The protein netrin-1 has demonstrated anti-inflammatory, tissue regeneration, and immune modulation properties. Although inflammation is a major contributing factor in the development of insulin resistance and type 2 diabetes, little is known about a possible relationship between serum netrin-1 and type 2 diabetes. Therefore, we investigated the association between circulating levels of netrin-1 and glycometabolic parameters predictive of type 2 diabetes. Read More

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November 2018

The anticancer activity of genistein is increased in estrogen receptor beta 1-positive breast cancer cells.

Onco Targets Ther 2018 14;11:8153-8163. Epub 2018 Nov 14.

Department of Breast and Thyroid Surgery, Breast Cancer Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, People's Republic of China,

Background: Most breast cancers are estrogen dependent and were sensitive to endocrine therapy, and genistein (GEN) shows strong affinity with human oestrogen receptor beta (ERβ).

Purpose: The present study aimed to investigate the anticancer activity of GEN in breast cancer cell lines that constitutively expressing ERβ1 in vitro and in vivo.

Methods: MCF-7/ERβ1 and MDA-MB-231/ERβ1 cell sub-lines were established through lentiviral infection. Read More

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November 2018

Which drugs cause treatment-related problems? Analysis of 10,672 problems within the outpatient setting.

Ther Clin Risk Manag 2018 16;14:2273-2281. Epub 2018 Nov 16.

School of Pharmacy and Pharmaceutical Science, University of Ulster, Coleraine, County Londonderry, UK.

Background: Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists' efforts to patients that are at high risk for TRPs.

Objectives: The present study aimed to identify medications most commonly associated with TRPs. Read More

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November 2018

The Effect of Single-Dose Intraperitoneal Bevacizumab on Peritoneal Adhesion Formation.

Rev Invest Clin 2018 ;70(6):279-284

Department of General Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey.

Background: Intra-abdominal adhesions and their complications following abdominal surgery are serious problems, with an incidence of 67-93%. Prevention of peritoneal adhesion formation may eliminate the need for surgical intervention, decreasing complications, morbidity, and cost. Bevacizumab is a recombinant monoclonal antibody which specifically binds vascular endothelial growth factor, an important cytokine in adhesion formation, and neutralizes its biological activity. Read More

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January 2018

Oncological Implications of Lymph Nodes Retrieval and Perineural Invasion in Colorectal Cancer: Outcomes from a Referral Center.

Rev Invest Clin 2018 ;70(6):291-300

Department of Endocrine Surgery. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: In colorectal cancer (CRC), regional lymphadenectomy provides prognostic information and guides management. The current consensus states that at least 12 lymph nodes (LN) should be evaluated. The aims of this study were to identify whether the number of LN is a predictor for survival and recurrence, and to reveal the role of LN ratio (LNR) and perineural invasion (PNI) in predicting prognosis after curative resection of CRC. Read More

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January 2018

Falls, fractures and vitamin D: a never-ending story?

Nat Rev Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.

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December 2018

Endocrine response to high intensity barbell squats performed with constant movement tempo and variable training volume.

Neuro Endocrinol Lett 2018 Oct 12;39(4):342-348. Epub 2018 Oct 12.

Charles University in Prague, Faculty of Physical Education and Sport, Department of Sport Games, Prague, Czech Republic.

Objective: Research indicates that among the many elements of resistance exercise protocols, training volume and total training load are the key factors for post-exercise increase in the secretion of testosterone (T), growth hormone (GH), insulin-like growth factor (IGF-1) and cortisol (C). The aim of this study was to determine the effects of resistance exercises with variable volume and constant intensity and movement tempo on post-exercise concentrations of selected anabolic and catabolic hormones.

Materials And Methods: 28 experienced powerlifters (27. Read More

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October 2018

Bisphenol A as an environmental pollutant with dual genotoxic and DNA-protective effects.

Neuro Endocrinol Lett 2018 Oct 12;39(4):294-298. Epub 2018 Oct 12.

Department of Genetics, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia.

Objectives: Bisphenol A (BPA) is an endocrine disruptor which has been shown to be a harmful compound for living organisms. It is the main component of the most commonly used plastic products such as plastic bottles, food cans and containers or dental fillings, and other medical aids. Recently, it has become a new environmental pollutant. Read More

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October 2018

Use of the TRH Stimulation Test to Assess Long Term Changes of Thyroid Function in an Olympic Athlete.

Curr Sports Med Rep 2018 Dec;17(12):454-456

Endocrinology Associates of Houston, Houston, TX.

This case report presents the utility of the thyroid-releasing hormone (TRH) stimulation test for assessing endocrine disease in athletes. On two occasions, 4 years apart (1992 and 1996), a TRH stimulation test was performed to corroborate clinical symptoms and observation. On the first occasion, the patient's symptoms were not attributed to thyroid disease. Read More

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December 2018

Proton beam therapy in pediatric oncology.

Curr Opin Pediatr 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

Purpose Of Review: The advent of proton beam therapy (PBT) has initiated a paradigm shift in the field of pediatric radiation oncology, with increasing promise to alleviate both short-term and long-term toxicities. Given the dramatic rise in proton therapy centers in the United States, a discussion of the quality of evidence supporting its use in pediatric cancers is warranted.

Recent Findings: Proton radiotherapy appears to decrease the incidence and severity of late effects with the strongest evidence in pediatric brain tumor cohorts that shows benefits in neurocognitive, hearing, and endocrine outcomes. Read More

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December 2018

Hatano rats selectively bred for high- and low-avoidance learning: an overview.

Exp Anim 2018 Dec 10. Epub 2018 Dec 10.

Hatano Research Institute, Food and Drug Safety Center.

This review compiles the results of a series of studies on Hatano high- and low-avoidance animals (HAA and LAA, respectively) established at the Hatano Research Institute, Food and Drug Safety Center, Japan. The HAA and LAA lines were selected and bred from Sprague Dawley rats for high and low avoidance learning, respectively, in a shuttlebox task since 1985. Although Hatano rats were selected only based on their behavioral traits in the active avoidance task, strain differences between the HAA and LAA lines were also observed in their stress responses and reproductive functions. Read More

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December 2018

[Pharmacological profile and clinical findings of palbociclib (IBRANCE capsule 25 mg/125 mg)].

Nihon Yakurigaku Zasshi 2018 ;152(6):306-318

Medical Affairs Oncology, Pfizer Japan Inc.

Palbociclib is the world's first cyclin dependent kinase (CDK) 4 and 6 inhibitor. It's believed that palbociclib stops the cell cycle progression by inhibiting the activity of the complex consisting of CDK 4/6 and cyclin D, and suppresses tumor growth. In preclinical study using nonclinical model, it was confirmed that most of the cell lines sensitive to palbociclib are estrogen receptor (ER) positive. Read More

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January 2018

Inhibin B: are modified ranges needed for orchiectomised testicular cancer patients?

Asian J Androl 2018 Dec 7. Epub 2018 Dec 7.

Laboratory of Seminology, Sperm Bank "Loredana Gandini", Department of Experimental Medicine, Medical Pathophysiology Section, "Sapienza" University of Rome, Rome 00161, Italy.

Inhibin B is a gonadal hormone that downregulates the pituitary production of follicle-stimulating hormone (FSH). In recent years, inhibin B has proved to be an excellent marker of spermatogenesis and even a predictive factor for the recovery of fertility in patients undergoing orchiectomy and antineoplastic treatments. We propose to study inhibin B levels in orchiectomised testicular cancer patients, in order to identify a minimum value representative of normal semen quality. Read More

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December 2018

A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesis.

Neural Regen Res 2019 Feb;14(2):217-221

Department of Human Sciences, The Ohio State University, Columbus, OH, USA.

White adipose tissue (WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocular adipocytes express thermogenic genes and have phenotypic similarity with thermogenic brown adipose tissue. Read More

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February 2019

Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity.

J Clin Invest 2018 Dec 10. Epub 2018 Dec 10.

Department of Hematology and Oncology, School of Medicine, UCSF, San Francisco, California, USA.

While immune checkpoint blockade leads to potent antitumor efficacy, it also leads to immune-related adverse events in cancer patients. These toxicities stem from systemic immune activation resulting in inflammation of multiple organs, including the gastrointestinal tract, lung, and endocrine organs. We developed a dual variable domain immunoglobulin of anti-CTLA4 antibody (anti-CTLA4 DVD, where CTLA4 is defined as cytotoxic T lymphocyte-associated antigen-4) possessing an outer tumor-specific antigen-binding site engineered to shield the inner anti-CTLA4-binding domain. Read More

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December 2018

The key role of a glucagon-like peptide-1 receptor agonist in body fat redistribution.

J Endocrinol 2019 Feb;240(2):271-286

Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are an ideal therapy for type 2 diabetes and, as of recently, for obesity. In contrast to visceral fat, subcutaneous fat appears to be protective against metabolic diseases. Here, we aimed to explore whether liraglutide, a GLP-1RA, could redistribute body fat via regulating lipid metabolism in different fat depots. Read More

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February 2019

Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.

J Endocrinol 2019 Feb;240(2):R21-R45

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.

While 95% of pituitary adenomas arise sporadically without a known inheritable predisposing mutation, in about 5% of the cases they can arise in a familial setting, either isolated (familial isolated pituitary adenoma or FIPA) or as part of a syndrome. FIPA is caused, in 15-30% of all kindreds, by inactivating mutations in the AIP gene, encoding a co-chaperone with a vast array of interacting partners and causing most commonly growth hormone excess. While the mechanisms linking AIP with pituitary tumorigenesis have not been fully understood, they are likely to involve several pathways, including the cAMP-dependent protein kinase A pathway via defective G inhibitory protein signalling or altered interaction with phosphodiesterases. Read More

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February 2019

Inhibitors of apoptosis protect the ovarian reserve from cyclophosphamide.

J Endocrinol 2019 Feb;240(2):243-256

Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Cancer therapy can cause off-target effects including ovarian damage, which may result in primary ovarian insufficiency in girls and premenopausal women. Loss of ovarian follicles within the ovarian reserve leads to ovarian endocrine dysfunction and impaired fertility. Cyclophosphamide (CPA), a commonly used chemotherapeutic and immunosuppressant agent, is a gonadotoxic agent that destroys ovarian cells by crosslinking DNA. Read More

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February 2019

Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.

J Immunol 2018 Dec 7. Epub 2018 Dec 7.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611;

Muscle dysfunction is common in patients with adult respiratory distress syndrome and is associated with morbidity that can persist for years after discharge. In a mouse model of severe influenza A pneumonia, we found the proinflammatory cytokine IL-6 was necessary for the development of muscle dysfunction. Treatment with a Food and Drug Administration-approved Ab antagonist to the IL-6R (tocilizumab) attenuated the severity of influenza A-induced muscle dysfunction. Read More

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December 2018

Biodegradation patterns of the endocrine disrupting pollutant di(2-ethyl hexyl) phthalate by Fusarium culmorum.

Ecotoxicol Environ Saf 2018 Dec 7;170:293-299. Epub 2018 Dec 7.

Laboratory of Biotechnology, Research Centre for Biological Sciences, Universidad Autónoma de Tlaxcala, Ixtacuixtla C.P. 90062, Tlaxcala, Mexico. Electronic address:

Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer, which is considered an endocrine disrupting pollutant. Growth kinetics and esterases activity by biochemical tests and polyacrylamide gel electrophoresis were characterized for Fusarium culmorum grown in DEHP-supplemented (1000 mg/L) medium as the only carbon source and in control medium with glucose. Intermediate compounds of biodegraded DEHP were identified by GC-MS. Read More

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December 2018
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