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    1748 results match your criteria Endocrine Myopathies

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    Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues.
    Elife 2018 May 29;7. Epub 2018 May 29.
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, United States.
    Skeletal muscle comprises a family of diverse tissues with highly specialized functions. Many acquired diseases, including HIV and COPD, affect specific muscles while sparing others. Even monogenic muscular dystrophies selectively affect certain muscle groups. Read More
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    [Indirect and mixed mechanisms of action in toxic myopathies].
    Ann Pharm Fr 2018 May 24. Epub 2018 May 24.
    Service de toxicologie, CHU Bab-El-Oued, rue Mohamed Lamine Debaghine, 16009 Alger, Algérie; Centre national de toxicologie, route du petit Staouali Delly Brahim, 16062 Alger, Algérie.
    Toxic myopathies are a group of pathologies characterized by a structural and/or functional disturbance of muscles induced by an exogenous agent. The most frequent are those induced by drugs used in clinical practice. Illegal drugs, pesticides, solvents, metals and even physical and gaseous agents can cause this kind of disease and exert toxicity on muscle tissues. Read More
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    Electro-acupuncture attenuates inflammatory responses and intraabdominal pressure in septic patients: A randomized controlled trial.
    Medicine (Baltimore) 2018 Apr;97(17):e0555
    Intensive Care Unit, Tongde Hospital of Zhejiang Province.
    Background: A pathological increase in intraabdominal pressure (IAP) and inflammatory responses have negative effects on splanchnic, respiratory, cardiovascular, renal, and neurological function in septic patients with intestinal dysfunction. Electro-acupuncture (EA) has been evidenced to have a bidirectional neuron-endocrine-immune system regulating effect in patients with intestinal dysfunction. The purpose of current study was to evaluate the effects of EA at "Zusanli" (ST36) and "Shangjuxu" (ST37) on inflammatory responses and IAP in septic patients with intestinal dysfunction manifested syndrome of obstruction of the bowels Qi. Read More
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    Clinical and laboratory features of patients with osteomalacia initially presenting with neurological manifestations.
    Osteoporos Int 2018 Apr 5. Epub 2018 Apr 5.
    Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
    Patients with osteomalacia often visit the neurology department with conditions mimicking other myopathies. We analyzed clinical features of osteomalacia patients who visited the neurology department. These patients frequently presented with hypocalcemia, hypovitaminosis D, and pain with less severe weakness. Read More
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    [Dropped head syndrome as first manifestation of primary hyperparathyroid myopathy].
    Rinsho Shinkeigaku 2018 Mar 28;58(3):193-197. Epub 2018 Mar 28.
    Department of Neurology, JA Toride Medical Center.
    75 years old woman presented with 6-month history of progressive dropped head syndrome. Neurological examination revealed moderate weakness of flexor and extensor of neck and mild weakness of proximal appendicular muscles with normal deep tendon reflexes. The needle electromyography showed short duration and low amplitude motor unit potential. Read More
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    The metabolic and endocrine characteristics in spinal and bulbar muscular atrophy.
    J Neurol 2018 May 20;265(5):1026-1036. Epub 2018 Feb 20.
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
    Objective: Spinal and bulbar muscular atrophy (SBMA) is caused by an abnormal expansion of the CAG repeat in the androgen receptor gene. This study aimed to systematically phenotype a German SBMA cohort (n = 80) based on laboratory markers for neuromuscular, metabolic, and endocrine status, and thus provide a basis for the selection of biomarkers for future therapeutic trials.

    Methods: We assessed a panel of 28 laboratory parameters. Read More
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    [New Diagnostic Biomarkers for Chronic Fatigue Syndrome].
    Brain Nerve 2018 Jan;70(1):27-34
    Health Metrics Development Team, RIKEN Compass to Healthy Life Research Complex Program.
    Chronic fatigue syndrome (CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with/without symptoms of infection or neuropsychiatric symptoms, and with a minimum duration of 6 consecutive months. The pathogenesis of CFS is not fully understood. There are no firmly established diagnostic biomarkers or treatment, due to incomplete understanding of the etiology of CFS and diagnostic uncertainty. Read More
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    The water extract of Liuwei dihuang possesses multi-protective properties on neurons and muscle tissue against deficiency of survival motor neuron protein.
    Phytomedicine 2017 Oct 18;34:97-105. Epub 2017 Aug 18.
    Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Electronic address:
    Background: Deficiency of survival motor neuron (SMN) protein, which is encoded by the SMN1 and SMN2 genes, induces widespread splicing defects mainly in spinal motor neurons, and leads to spinal muscular atrophy (SMA). Currently, there is no effective treatment for SMA. Liuwei dihuang (LWDH), a traditional Chinese herbal formula, possesses multiple therapeutic benefits against various diseases via modulation of the nervous, immune and endocrine systems. Read More
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    Connecting the Dots.
    N Engl J Med 2017 09;377(10):978-984
    From the Department of Medicine (R.P.R., A.P.S., A.A.P., A.B., A.S.D.) and Institute for Health Policy Management and Evaluation (A.S.D.), University of Toronto, and the Department of Medicine, University Health Network and Mount Sinai Hospital (A.A.P., A.B., A.S.D.), Toronto, and the Department of Medicine, University of Ottawa, Ottawa (A.B.) - all in Canada.
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    Mazabraud syndrome associated with McCune-Albright syndrome: a case report and review of the literature.
    Acta Biomed 2017 Aug 23;88(2):198-200. Epub 2017 Aug 23.
    Gaetano Pini-CTO, Milano.
    Mazabraud syndrome is a very rare benign disorder characterized by the association of monostotic or polyostotic fibrous dysplasia and one or multiple intramuscular myxomas. McCune -Albright syndrome is a rare benign disorder characterized by the association of polyostotic fibrous dysplasia, cafè-au-lait skin pigmentations and endocrine dysfunction, such as precocious puberty, diabetes mellitus, goiter and breast fibroadenomatosis. The association of Mazabraud syndrome and McCune-Albright in the same patient is an anecdotal event. Read More
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    Severe hypokalaemia as a cause of acute transient quadriparesis.
    BMJ Case Rep 2017 Jul 27;2017. Epub 2017 Jul 27.
    Department of Internal Medicine, Regionshospitalet Randers, Randers, Denmark.
    Hypokalaemic paralysis covers a heterogeneous group of disorders caused either by an enhanced shift of potassium into the cells or following a significant renal or gastrointestinal loss of potassium. We present the case of a 48-year-old Caucasian man with paralysis of both upper and lower extremities. ECG showed sinus rhythm and characteristic changes of hypokalaemia with depression of the ST segment, prolonged QTc interval of 581ms and U waves seen as a small positive deflection at the T wave in the middle precordial leads. Read More
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    The PJ Nicholoff Steroid Protocol for Duchenne and Becker Muscular Dystrophy and Adrenal Suppression.
    PLoS Curr 2017 Jun 27;9. Epub 2017 Jun 27.
    Complex Care, Nationwide Children's Hospital, Columbus, OH, USA.
    Duchenne muscular dystrophy (DMD or Duchenne) is a progressive, life-limiting muscle-wasting disease that requires comprehensive, multidisciplinary care. This care, at minimum, should include neuromuscular, respiratory, cardiac, orthopedic, endocrine and rehabilitative interventions that address both the primary and secondary manifestations of the disease. The care needs of patients evolve over the cdourse of the disease and as they transition from childhood into young adulthood. Read More
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    Central Hemodynamics for Management of Arteriosclerotic Diseases.
    J Atheroscler Thromb 2017 Aug 10;24(8):765-778. Epub 2017 Jun 10.
    Medical Center, Miyagi University of Education.
    Arteriosclerosis, particularly aortosclerosis, is the most critical risk factor associated with cardiovascular, cerebrovascular, and renal diseases. The pulsatile hemodynamics in the central aorta consists of blood pressure, flow, and stiffness and substantially differs from the peripheral hemodynamics in muscular arteries. Arteriosclerotic changes with age appear earlier in the elastic aorta, and age-dependent increases in central pulse pressure are more marked than those apparent from brachial pressure measurement. Read More
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    Gastric Dilatation and Abdominal Compartment Syndrome in a Child with Prader-Willi Syndrome.
    Am J Case Rep 2017 Jun 7;18:637-640. Epub 2017 Jun 7.
    Department of Paediatric Endocrinology, Parc Tauli Sabadell, Hospital Universitari, Universitat Autònoma de Barcelona, Sabadell, Spain.
    BACKGROUND Prader-Willi syndrome (PWS) is a genetic disorder characterized by initial muscular hypotonia and feeding difficulties, and later an insatiable appetite, hyperphagia and obesity along with mild to moderate intellectual impairment. Affected individuals' food-seeking behavior and suspected delayed gastric emptying can lead to gastric dilatation with subsequent necrosis and perforation. CASE REPORT We present the case of a 5-year-old boy diagnosed with Prader-Willi syndrome at neonatal age due to muscular hypotonia, who started growth hormone therapy at 20 months. Read More
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    A case of stiff-person syndrome due to secondary adrenal insufficiency.
    Rinsho Shinkeigaku 2017 06 26;57(6):298-302. Epub 2017 May 26.
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University.
    We report a case of flexion contractures in a patient's legs secondary to postpartum hypopituitarism. A 56-year-old woman presented with a 3-year history of worsening flexion contractures of the hips and knees. On admission, her hips and knees could not be extended, and she had muscle stiffness and tenderness to palpation of the lower extremities. Read More
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    Serum levels of adipokines in patients with idiopathic inflammatory myopathies: a pilot study.
    Rheumatol Int 2017 Aug 23;37(8):1341-1345. Epub 2017 May 23.
    Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
    Adipokines are cytokines not only regulating metabolic and endocrine activities, but also modulating inflammatory and immune responses in several clinical settings, including autoimmunity. This study was aimed to evaluate whether serum adipokine levels may be useful as markers of disease activity in patients with idiopathic inflammatory myopathies (IIM). Adiponectin, leptin, chemokine C-C motif ligand-2 (CCL2), interleukin (IL)-6, and tumor necrosis factor (TNF) were measured in the serum of all participants. Read More
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    Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness.
    J Vis Exp 2017 05 2(123). Epub 2017 May 2.
    Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven;
    This protocol describes a centrally catheterized mouse model of prolonged critical illness. We combine the cecal ligation and puncture method to induce sepsis with the use of a central venous line for fluids, drugs and nutrient administration to mimic the human clinical setting. Critically ill patients require intensive medical support in order to survive. Read More
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    Comparison of the recovery response from high-intensity and high-volume resistance exercise in trained men.
    Eur J Appl Physiol 2017 07 26;117(7):1287-1298. Epub 2017 Apr 26.
    Sport and Exercise Science, University of Central Florida, Orlando, FL, 32766, USA.
    Purpose: The purpose of this study was to compare the physiological responses of a high-volume (HV; 8 sets of 10 repetitions) versus high-intensity (HI; 8 sets of 3 repetitions) exercise protocol in resistance-trained men.

    Methods: Twelve men (24.5 ± 4. Read More
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    The effect of high-dose vitamin D supplementation on muscular function and quality of life in postmenopausal women-A randomized controlled trial.
    Clin Endocrinol (Oxf) 2017 Jul 11;87(1):20-28. Epub 2017 May 11.
    Tromsø Endocrine Research Group, Institute of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
    Objective: Observational studies have suggested positive associations between serum 25-hydroxyvitamin D (25(OH)D) levels and muscular strength, balance and quality of life. Our aim was to examine whether high-dose vitamin D supplementation would improve these measures as compared to standard-dose vitamin D, as well as the possible muscular effects of single nucleotide polymorphisms (SNPs) in genes encoding vitamin D-related enzymes.

    Design: A 12-month randomized, double-blind, controlled trial where the participants received daily elemental calcium (1000 mg) plus vitamin D (800 IU). Read More
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    Inherited and Acquired Muscle Weakness: A Moving Target for Diagnostic Muscle Biopsy.
    Neuropediatrics 2017 Aug 15;48(4):226-232. Epub 2017 Apr 15.
    Friedrich-Baur-Institut, Neurologische Klinik, Klinikum der Universität München, München, Germany.
    Inherited and acquired muscular weakness is caused by multiple conditions. While the inherited ones are mostly caused by mutations in genes coding for myopathic or neurogenic diseases, the acquired ones occur due to inflammatory, endocrine, or toxic etiologies. Precise diagnosis of a specific disease may be challenging and may require a multidisciplinary approach. Read More
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    Study on the morphology, histology and enzymatic activity of the digestive tract of Gymnocypris eckloni Herzenstein.
    Fish Physiol Biochem 2017 Aug 7;43(4):1175-1185. Epub 2017 Apr 7.
    Chengdu Academy of Agriculture and Forestry Sciences, Chengdu, Sichuan, 611130, China.
    The present research was conducted to study the morphology, histology and enzymatic activities of the digestive tract of Gymnocypris eckloni by light and transmission electron microscopes as well as by enzyme assays. The digestive tract of G. eckloni consisted of the oropharyngeal cavity, oesophagus and intestine. Read More
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    Lower Jump Power Rather Than Muscle Mass Itself is Associated with Vertebral Fracture in Community-Dwelling Elderly Korean Women.
    Calcif Tissue Int 2017 06 9;100(6):585-594. Epub 2017 Mar 9.
    Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Sarcopenia is considered to be a risk factor for osteoporotic fracture, which is a major health problem in elderly women. In this study, we aimed to investigate the association of sarcopenia, with regard to muscle mass and function, with prevalent vertebral fracture in community-dwelling elderly women. We recruited 1281 women aged 64 to 87 years from the Korean Urban Rural Elderly cohort study. Read More
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    A case of primary aldosteronism caused by unilateral multiple adrenocortical micronodules presenting as muscle cramps at rest: The importance of functional histopathology for identifying a culprit lesion.
    Pathol Int 2017 Apr 5;67(4):214-221. Epub 2017 Mar 5.
    Department of Diagnostic Pathology, Jichi Medical University Hospital, Shimotsuke, Japan.
    Unilateral multiple adrenocortical micronodules (UMNs) constitute a rare subset of primary aldosteronism (PA) characterized by the hypersecretion of aldosterone derived from multiple small nodules in the zona glomerulosa of the unilateral adrenal grand. This case study describes a 49-year-old man with PA and UMNs who presented with muscle cramps at rest due to hypokalemia. The patient had a 6-year history of hypertension treated with antihypertensive drugs. Read More
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    Epigenetic modifications and glucocorticoid sensitivity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
    BMC Med Genomics 2017 02 23;10(1):11. Epub 2017 Feb 23.
    Department of Biological Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, M1C 1A4, Canada.
    Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating idiopathic disease characterized by unexplained fatigue that fails to resolve with sufficient rest. Diagnosis is based on a list of symptoms and exclusion of other fatigue-related health conditions. Despite a heterogeneous patient population, immune and hypothalamic-pituitary-adrenal (HPA) axis function differences, such as enhanced negative feedback to glucocorticoids, are recurring findings in ME/CFS studies. Read More
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    A Case of Asymptomatic Inclusion Body Myositis.
    J Clin Neuromuscul Dis 2017 Mar;18(3):132-134
    Department of Neurology, University of Tennessee Health Science Center, Memphis, TN.
    Objectives: To present a case of asymptomatic inclusion body myositis.

    Methods: The authors report a case of a 67-year-old man who presented with idiopathic hyperCKemia. Physical examination including a complete neurological evaluation was unremarkable. Read More
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    Sclerostin antibody inhibits skeletal deterioration in mice exposed to partial weight-bearing.
    Life Sci Space Res (Amst) 2017 Feb 12;12:32-38. Epub 2017 Jan 12.
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, United Staes ; Endocrine Division, Massachusetts General Hospital, Boston, MA, United Staes; Department of Orthopaedic Surgery, Harvard Medical School, Boston, MA, United Staes. Electronic address:
    Whereas much is known regarding the musculoskeletal responses to full unloading, little is known about the physiological effects and response to pharmacological agents in partial unloading (e.g. Moon and Mars) environments. Read More
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    Evaluation of the severity of capsular contracture using elastography after breast implant reconstruction.
    Clin Hemorheol Microcirc 2017 ;66(1):1-6
    Department of Plastic and Reconstructive Surgery, Kyoto Prefectural University of Medicine, Graduate School of Medical Sciences, Kyoto, Japan.
    Background: Capsular contracture around implants is a common complication after breast reconstruction. Strain elastography (STE) and shear-wave elastography (SWE) are noninvasive imaging techniques that can measure tissue stiffness and thickness of the capsule.

    Objective: The purposes of the study were to compare STE and SWE for measurement of capsular contracture after breast implant reconstruction using intra-class correlation coefficients (ICCs) and to investigate the correlation of these data with the Baker score, which is the most frequently used clinical staging scale for capsule contracture. Read More
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    The physiological response to cold-water immersion following a mixed martial arts training session.
    Appl Physiol Nutr Metab 2017 May 17;42(5):529-536. Epub 2017 Jan 17.
    b Free Radical Biochemistry Laboratory, School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
    Combative sport is one of the most physically intense forms of exercise, yet the effect of recovery interventions has been largely unexplored. We investigated the effect of cold-water immersion on structural, inflammatory, and physiological stress biomarkers following a mixed martial arts (MMA) contest preparation training session in comparison with passive recovery. Semiprofessional MMA competitors (n = 15) were randomly assigned to a cold-water immersion (15 min at 10 °C) or passive recovery protocol (ambient air) completed immediately following a contest preparation training session. Read More
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    Influence of stress systems and physical activity on different dimensions of fatigue in female fibromyalgia patients.
    J Psychosom Res 2017 02 11;93:55-61. Epub 2016 Dec 11.
    Clinical Biopsychology, Department of Psychology, University of Marburg, Gutenbergstr. 18, 35037 Marburg, Germany. Electronic address:
    Objective: Fatigue is a defining characteristic and one of the most debilitating features of fibromyalgia syndrome (FMS). The mechanisms underlying different dimensions of fatigue in FMS remain unclear. The aim of the current study was to test whether stress-related biological processes and physical activity modulate fatigue experience. Read More
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    Candidate SNP markers of aggressiveness-related complications and comorbidities of genetic diseases are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters.
    BMC Genomics 2016 12 28;17(Suppl 14):995. Epub 2016 Dec 28.
    Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 10 Lavrentyev Avenue, Novosibirsk, 630090, Russia.
    Background: Aggressiveness in humans is a hereditary behavioral trait that mobilizes all systems of the body-first of all, the nervous and endocrine systems, and then the respiratory, vascular, muscular, and others-e.g., for the defense of oneself, children, family, shelter, territory, and other possessions as well as personal interests. Read More
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    SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome.
    Nat Genet 2017 Feb 9;49(2):238-248. Epub 2017 Jan 9.
    Molecular Neurogenetics Unit and Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
    Arhinia, or absence of the nose, is a rare malformation of unknown etiology that is often accompanied by ocular and reproductive defects. Sequencing of 40 people with arhinia revealed that 84% of probands harbor a missense mutation localized to a constrained region of SMCHD1 encompassing the ATPase domain. SMCHD1 mutations cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) via a trans-acting loss-of-function epigenetic mechanism. Read More
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    Toxic and Endocrine Myopathies.
    Continuum (Minneap Minn) 2016 Dec;22(6, Muscle and Neuromuscular Junction Disorders):1815-1828
    Purpose Of Review: This article discusses the clinical features, pathophysiology, and management of toxic and endocrine myopathies.

    Recent Findings: Early detection and expeditious correction of metabolic disturbances in endocrinopathies such as Cushing syndrome, thyroid and parathyroid diseases, and acromegaly can minimize and prevent neurologic complications including myopathy. Recently proposed mechanisms of injury in patients with critical illness myopathy include inhibition of protein synthesis, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, oxidative stress, and disruption of intramuscular calcium homeostasis, which can cause a myosin-loss myopathy. Read More
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    Thyroid abscess in case of Pre B acute lymphoblastic leukaemia: a rare presentation.
    BMJ Case Rep 2016 Nov 29;2016. Epub 2016 Nov 29.
    Institute of Hematology and Transfusion Medicine, Medical College Kolkata, Kolkata, West Bengal, India.
    Thyroid abscess is a very rare clinical condition. It usually occurs in immunocompromised individuals or those with underlying malignancy. We report a case of multiple thyroid abscesses in the patient with Pre B acute lymphoblastic leukaemia which developed secondary to hematogenous spread from pyomyositis of right calf muscle. Read More
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    Myogenic temporomandibular disorders: Clinical systemic comorbidities in a female population sample.
    Med Oral Patol Oral Cir Bucal 2016 Nov 1;21(6):e784-792. Epub 2016 Nov 1.
    Máster en Dolor Orofacial y Disfunción Craneomandibular, Facultad de Medicina, Universidad CEU San Pablo, Urbanización Montepríncipe 28668, Boadilla del Monte, Madrid, Spain,
    Background: Myogenic temporomandibular disorders (MTMD) frequently coexist with other clinical conditions in the same individual. In the last decades, several authors have analyzed these comorbidities looking for the origin of this overlapping. Objetives: The aim of this study was to perform a comparative anaylisis between a group of patients with MTMD and a control group of dental patients without dysfunctional pathology to assess whether there are significant differences in the presence of systemic medical comorbidities between the two groups. Read More
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    Fibromyalgia in a Patient with Cushing's Disease Accompanied by Central Hypothyroidism.
    Intern Med 2016;55(21):3185-3190. Epub 2016 Nov 1.
    Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Japan.
    A 39-year-old woman with a 3-year history of a rounded face developed widespread myalgia. Detailed examinations revealed no disorders that could explain the pain other than concomitant Cushing's disease and central hypothyroidism. Both the hypercortisolemia and hypothyroidism completely resolved after the patient underwent surgery to treat Cushing's disease, but she continued to experience unresolved myalgia and met the diagnostic criteria for fibromyalgia. Read More
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    Sarcolipin: A Key Thermogenic and Metabolic Regulator in Skeletal Muscle.
    Trends Endocrinol Metab 2016 12 13;27(12):881-892. Epub 2016 Sep 13.
    Department of Physiology and Cell Biology, Ohio State University, Columbus, OH, USA; Sanford Burnham Medical Research Institute at Lake Nona, Orlando, FL, USA. Electronic address:
    Skeletal muscle constitutes ∼40% of body mass and has the capacity to play a major role as thermogenic, metabolic, and endocrine organ. In addition to shivering, muscle also contributes to nonshivering thermogenesis via futile sarcoplasmic/endoplasmic reticulum Ca ATPase (SERCA) activity. Sarcolipin (SLN), a regulator of SERCA activity in muscle, plays an important role in regulating muscle thermogenesis and metabolism. Read More
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    A rare case of a pineoblastoma with a rhabdomyoblastic component.
    Neuropathology 2017 Jun 24;37(3):227-232. Epub 2016 Oct 24.
    Division of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Itabashi, Tokyo, Japan.
    Pineal anlage tumor (PAT) is a rare subtype of pineoblastoma (PB), which shows a poor prognosis. We report a case of a 5-year-old boy with PB with a rhabdomyoblastic component. He presented at a local clinic with vomiting and was transferred to our hospital following discovery of a pineal mass. Read More
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    The Neuromuscular, Biochemical, and Endocrine Responses to a Single-Session Vs. Double-Session Training Day in Elite Athletes.
    J Strength Cond Res 2016 Nov;30(11):3098-3106
    1Strength and Conditioning Department, English Institute of Sport, Loughborough University, Loughborough, United Kingdom; 2Applied Sports, Technology, Exercise and Medicine (A-STEM) Research Centre, Swansea University, Swansea, United Kingdom; 3School of Sport, Health and Exercise Science, Bangor University, Bangor, United Kingdom; 4Strength and Conditioning Department, Ulster Rugby, Newforge Lane, Belfast, United Kingdom; 5Strength and Conditioning Department, Ulster Sports Academy, University of Ulster, Jordanstown, United Kingdom; and 6Department of Sport Science, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.
    Johnston, MJ, Cook, CJ, Drake, D, Costley, L, Johnston, JP, and Kilduff, LP. The neuromuscular, biochemical, and endocrine responses to a single-session vs. double-session training day in elite athletes. Read More
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    Secondary myopathy due to systemic diseases.
    Acta Neurol Scand 2016 Dec 25;134(6):388-402. Epub 2016 Feb 25.
    Department of Neurology, Kaiser-Franz-Josef Spital, Vienna, Austria.
    Background: Some systemic diseases also affect the skeletal muscle to various degrees and with different manifestations. This review aimed at summarizing and discussing recent advances concerning the management of muscle disease in systemic diseases.

    Method: Literature review by search of MEDLINE, and Current Contents with appropriate search terms. Read More
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    Treatable Bedridden Elderly -Recovery from Flexion Contracture after Cortisol Replacement in a Patient with Isolated Adrenocorticotropic Hormone Deficiency.
    Intern Med 2016;55(20):2975-2978. Epub 2016 Oct 15.
    Department of General Internal Medicine, Tazuke-Kofukai, Medical Research Institute, Kitano Hospital, Japan.
    Isolated adrenocorticotropic hormone deficiency (IAD) is a rare disorder with diverse clinical presentations. A 79-year-old man was bedridden for six months due to flexion contractures of the bilateral hips and knees, along with hyponatremia. He was diagnosed with IAD based on the results of endocrine tests. Read More
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    Identifying the culprit lesion in tumor induced hypophosphatemia, the solution of a clinical enigma.
    Endocrine 2016 Dec 5;54(3):642-647. Epub 2016 Oct 5.
    Center for Bone Quality and Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands.
    Tumor-induced osteomalacia is a rare acquired metabolic bone disorder characterized by isolated renal phosphate wasting due to abnormal tumor production of fibroblast growth factor 23. We report the case of a 59 year old woman referred to our department with a long history of progressive diffuse muscle weakness and pain, generalized bone pains and multiple insufficiency fractures of heels, ankles and hips due to a hypophosphatemic osteomalacia. A fibroblast growth factor 23-producing phosphaturic mesenchymal tumor localized in the left quadriceps femoris muscle was identified 7 years after onset of symptoms. Read More
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    Evaluation of Body Weight, Body Condition, and Muscle Condition in Cats with Hyperthyroidism.
    J Vet Intern Med 2016 Nov 26;30(6):1780-1789. Epub 2016 Sep 26.
    College of Veterinary Medicine, Cornell University, Ithaca, NY.
    Background: The contribution of fat loss versus muscle wasting to the loss of body weight seen in hyperthyroid cats is unknown.

    Objectives: To investigate body weight, body condition score (BCS), and muscle condition score (MCS) in hyperthyroid cats.

    Animals: Four hundred sixty-two cats with untreated hyperthyroidism, 117 of which were reevaluated after treatment. Read More
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    First case of bilateral coronoid hyperplasia in monozygotic twin sisters-a new aetiological perspective?
    Oral Maxillofac Surg 2016 Dec 16;20(4):441-443. Epub 2016 Sep 16.
    Department of maxillofacial surgery, University Hospital Birmingham NHS Trust, Birmingham, UK.
    Background: Mandibular coronoid hyperplasia is a rare condition associated with gradual reduction in mouth opening. Its aetiology is unknown but increased temporalis activity, endocrine stimulus, trauma and familial causes have been proposed.

    Case Report: In this article, we present a case of bilateral coronoid hyperplasia presenting with limited mouth opening in 16-year-old Caucasian twin sisters. Read More
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    NMR WaterLOGSY Reveals Weak Binding of Bisphenol A with Amyloid Fibers of a Conserved 11 Residue Peptide from Androgen Receptor.
    PLoS One 2016 1;11(9):e0161948. Epub 2016 Sep 1.
    Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U596, CNRS UMR 7104, Université de Strasbourg, Illkirch-Graffenstaden, France.
    There is growing evidence that bisphenol A (BPA), a molecule largely released in the environment, has detrimental effects on ecosystems and on human health. It acts as an endocrine disruptor targeting steroid hormone receptors, such as the estrogen receptor (ER), estrogen-related receptor (ERR) and androgen receptor (AR). BPA-derived molecules have recently been shown to interact with the AR N-terminal domain (AR-NTD), which is known to be largely intrinsically disordered. Read More
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    Diagnosis and treatment of rare complications of pelvic fractures.
    Chin J Traumatol 2016 Aug;19(4):199-205
    State Key Laboratory of Trauma, Burns and Combined Injury, Department of Trauma Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
    Purpose: To enhance the awareness of rare complications of pelvic fracture and describe the correct diagnosis and effective treatment.

    Methods: A total of 188 cases of pelvic fractures were retrospectively reviewed, and four patients who suffered from four types of rare pelvic fracture complications were described, namely ureteral obstruction caused by retroperitoneal hematoma-induced abdominal compartment syndrome (ACS), bowel entrapment, external iliac artery injury, and open scrotal sac injury.

    Results: We demonstrated that combined measures should be employed to prevent the occurrence of ACS following major pelvic fractures. Read More
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    Parathyroid adenoma arising within the sternocleidomastoid muscle: a rare complication of autotransplantation.
    BMJ Case Rep 2016 Jul 20;2016. Epub 2016 Jul 20.
    Department of Radiology, St. George's Hospital NHS Trust, London, UK Department of Head & Neck Radiology, University College Hospital, London, UK.
    A 19-year-old patient presented with slowly enlarging, painless, left-sided cervical mass. She had a background of multiple endocrine neoplasia 2B and had undergone a total thyroidectomy for medullary thyroid carcinoma during childhood. A cervical recurrence was therefore suspected. Read More
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    Investigating unexplained fatigue in general practice with a particular focus on CFS/ME.
    BMC Fam Pract 2016 07 19;17:81. Epub 2016 Jul 19.
    Department of Immunology and Allergy, St. Helier Hospital, Carshalton, Surrey, SM5 1AA, UK.
    Unexplained fatigue is not infrequent in the community. It presents a number of challenges to the primary care physician and particularly if the clinical examination and routine investigations are normal. However, while fatigue is a feature of many common illnesses, it is the main problem in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Read More
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    Goserelin toxicities and preferences for ovarian suppression method in pre-menopausal women with breast cancer.
    Intern Med J 2016 Oct;46(10):1153-1159
    Department of Medical Oncology, Flinders Medical Centre, Adelaide, South Australia, Australia.
    Background: Goserelin, a form of medical ovarian suppression, is an effective treatment for pre-menopausal women with breast cancer (PMBC). Meta-analysis data showed that similar efficacy is achieved with medical ovarian suppression and non-pharmacological ovarian suppression (NPOS) - oophorectomy or ovarian irradiation. The acceptance rate of NPOS remains low. Read More
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