29,184 results match your criteria Endocrine Metabolic & Immune Disorders - Drug Targets[Journal]


ΔFosB Requires Galanin, but not Leptin, to Increase Bone Mass via the Hypothalamus, but both are needed to increase Energy Expenditure.

J Bone Miner Res 2019 Apr 18. Epub 2019 Apr 18.

Department of Medicine, Harvard Medical School and Endocrine Unit MGH, and Division of Bone and Mineral Metabolism, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.

Energy metabolism and bone homeostasis share several regulatory pathways. The AP1 transcription factor ΔFosB and leptin both regulate energy metabolism and bone, yet whether their pathways intersect is not known. Transgenic mice overexpressing ΔFosB under the control of the Enolase 2 (ENO2) promoter exhibit high bone mass, high energy expenditure, low fat mass and low circulating leptin levels. Read More

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http://dx.doi.org/10.1002/jbmr.3741DOI Listing

Response to Letter to the Editor: Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society* Clinical Practice Guideline.

J Clin Endocrinol Metab 2019 Apr 18. Epub 2019 Apr 18.

Professor of Medicine Tufts University School of Medicine, Maine Medical Center Research Institute, Scarborough, Maine USA.

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2019-00777DOI Listing
April 2019
1 Read

Animal models of polycystic ovary syndrome: A review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides.

Reprod Med Biol 2019 Apr 28;18(2):151-160. Epub 2018 Dec 28.

Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age and a major cause of infertility; however, the pathophysiology of this syndrome is not fully understood. This can be addressed using appropriate animal models of PCOS. In this review, we describe rodent models of hormone-induced PCOS that focus on the perturbation of the hypothalamic-pituitary-ovary (HPO) axis and abnormalities in neuropeptide levels. Read More

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http://dx.doi.org/10.1002/rmb2.12262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452010PMC

GLP-1 induces alpha cell proliferation and overrides leptin suppression induced by negative energy balance in vagotomized rats.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Endocrine, Cardiovascular & Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

Glucagon-like peptide-1 (GLP-1) influences energy balance by exerting effects on food intake and glucose metabolism, through mechanisms that are partially dependent on the vagal pathway. The aim of this study was to characterize the effects of chronic GLP-1 stimulation on energy homeostasis and glucose metabolism in the absence of vagal innervation Truncal vagotomized (VGX) and sham operated rats (SHAM) received an intraperitoneal GLP-1 infusion (3.5 pmol/kg/min) trough mini-osmotic pumps. Read More

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http://dx.doi.org/10.1002/jcb.28719DOI Listing

Comparing the effects of ipragliflozin versus metformin on visceral fat reduction and metabolic dysfunction in Japanese patients with type 2 diabetes treated with sitagliptin: A prospective, multicentre, open-label, blinded-endpoint, randomised controlled study (PRIME-V study).

Diabetes Obes Metab 2019 Apr 17. Epub 2019 Apr 17.

Department of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, Chiba, Japan.

A prospective, multicentre, open-label, blinded-endpoint, randomised controlled study was conducted to evaluate the efficacy of treatment with ipragliflozin (sodium-dependent glucose transporter-2 inhibitor) versus metformin for visceral fat reduction and glycaemic control among Japanese patients with type 2 diabetes treated with sitagliptin, HbA1c levels of 7-10%, and BMI ≥22 kg/m . Patients were randomly assigned (1:1) to receive ipragliflozin 50 mg or metformin 1000-1500 mg daily. The primary outcome was change in visceral fat area as measured by computed tomography after 24 weeks of therapy. Read More

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http://dx.doi.org/10.1111/dom.13750DOI Listing
April 2019
1 Read

Activation profiles of monocyte-macrophages and HDL function in healthy women in relation to menstrual cycle and in polycystic ovary syndrome patients.

Endocrine 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, University of Padova, Padova, Italy.

Purpose: Hormonal status and menopause affect human macrophage function and cardiometabolic risk. In polycystic ovary syndrome (PCOS) patients the cardiometabolic risk increases through mechanisms that are largely unknown. We tested the hypotheses that macrophage activation is influenced by menstrual cycle and that ovarian dysfunction in PCOS patients is associated with altered macrophage inflammatory responses and cholesterol efflux capacity of serum HDL. Read More

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http://dx.doi.org/10.1007/s12020-019-01911-2DOI Listing

Impact of Socioeconomic Characteristics on Metabolic Control in Children with Type One Diabetes in a Developing Country

J Clin Res Pediatr Endocrinol 2019 Apr 17. Epub 2019 Apr 17.

The National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), University of Jordan, Amman, Jordan

Background: Adequate glycemic control in children with type 1 diabetes reduces the risk of future complications. Identifying factors affecting HbA1c is crucial to achieve adequate metabolic control. We aim to identify possible socioeconomic predictors of poor metabolic control in children with type 1 diabetes in Jordan; which resembles a developing country with limited resources. Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2019.2019.0014DOI Listing

Berberine stimulates fibroblast growth factor 21 by modulating the molecular clock component brain and muscle Arnt-like 1 in brown adipose tissue.

Biochem Pharmacol 2019 Apr 13;164:165-176. Epub 2019 Apr 13.

Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, Nagoya 464-8650, Japan.

Fibroblast growth factor 21 (FGF21), a member of the FGF subfamily that acts through the FGF receptor 1 with the co-receptor β-Klotho, functions as an important metabolic regulator of peripheral glucose tolerance and lipid homeostasis in an endocrine or autocrine and/or paracrine manner. Previous studies showed that FGF21 ameliorated and prevented the development of metabolic disorders, such as obesity and diabetes mellitus. In the present study, we demonstrated that berberine, a naturally occurring compound, stimulated FGF21 expression in brown adipose tissue (BAT). Read More

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http://dx.doi.org/10.1016/j.bcp.2019.04.017DOI Listing

Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation.

J Clin Invest 2019 Apr 16;130. Epub 2019 Apr 16.

Preclinical studies demonstrate that rapid acting antidepressants, including ketamine require stimulation of mTORC1 signaling. This pathway is regulated by neuronal activity, endocrine and metabolic signals, notably the amino acid leucine, which activates mTORC1 signaling via binding to the upstream regulator sestrin. Here, we examined the antidepressant actions of NV-5138, a novel highly selective small molecule modulator of sestrin that penetrates the blood brain barrier. Read More

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http://dx.doi.org/10.1172/JCI126859DOI Listing

High prevalence of benign mammary tumors in a rat model of polycystic ovary syndrome during postmenopausal period.

Gynecol Endocrinol 2019 Apr 16:1-6. Epub 2019 Apr 16.

a Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-age women. Significant associations between PCOS and benign breast diseases (BBD) and a possibly potential association between PCOS and breast cancer have been reported. The etiology of these events of mammary glands in PCOS remains unclear. Read More

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http://dx.doi.org/10.1080/09513590.2019.1576613DOI Listing

Glucagon-like peptide-1 modulates RAW264.7 macrophage polarization by interfering with the JNK/STAT3 signaling pathway.

Authors:
Shan Wan Hui Sun

Exp Ther Med 2019 May 6;17(5):3573-3579. Epub 2019 Mar 6.

Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.

Insulin resistance and metabolic disorders are closely associated with low-grade chronic inflammation. Aberrant macrophage activation to M1 or M2 is characterized by a deleterious state of chronic inflammation and loss of positive trophic signals. Glucagon-like peptide-1 (GLP-1) is used to treat diabetes due to its beneficial role against insulin resistance. Read More

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http://dx.doi.org/10.3892/etm.2019.7347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447820PMC

Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates.

J Biol Chem 2019 Apr 15. Epub 2019 Apr 15.

University of California Davis.

Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis associated () gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases of metabolism. However, adropin's roles in human metabolism are unclear. expression profiling in a nonhuman primate diurnal transcriptome atlas (GSE98965) revealed a dynamic and diurnal pattern of expression. Read More

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http://dx.doi.org/10.1074/jbc.RA119.007528DOI Listing

Weight loss probiotic supplementation effect in overweight and obesity subjects: A review.

Clin Nutr 2019 Apr 3. Epub 2019 Apr 3.

Curso de Nutrição do Centro Universitário São Camilo, São Paulo, SP, Brazil; Brazilian Association of Sport Nutrition, São Paulo, SP, Brazil; Universidade de São Paulo, Programa de Pós-graduação em Nutrição em Saúde Pública, São Paulo, SP, Brazil. Electronic address:

Obese individuals present adverse changes in the diversity and composition of the gut microbiota, leading to alterations in energy balance, lipid metabolism, endocrine disturbances, and low-grade chronic systemic inflammation increases. Probiotic supplementation appears to change gut microbiota by decrease gut permeability, inflammation, and metabolic disorders, creating a promising environment to weight loss. This revision resumes the main findings of probiotic supplementation and weight loss that contributed to building the current background linking changes in gut microbiota profile and with obesity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193014
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http://dx.doi.org/10.1016/j.clnu.2019.03.034DOI Listing
April 2019
7 Reads

Correction to: National trends of pre-hypertension and hypertension among Iranian adolescents across urban and rural areas (2007-2011).

Biol Sex Differ 2019 Apr 15;10(1):18. Epub 2019 Apr 15.

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1186/s13293-019-0234-xDOI Listing

Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance.

Cancers (Basel) 2019 Apr 4;11(4). Epub 2019 Apr 4.

Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.

A majority of breast cancer specific deaths in women with ERα (+) tumors occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to resensitize recurrent ERα (+) tumors to endocrine therapies. The objective of this study was to elucidate mechanisms of improved effectiveness of combined targeting of ERα and the nuclear transport protein XPO1 in overcoming endocrine resistance. Read More

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http://dx.doi.org/10.3390/cancers11040479DOI Listing

Update on Management of Polycystic Ovarian Syndrome for Dermatologists.

Indian Dermatol Online J 2019 Mar-Apr;10(2):97-105

Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Polycystic ovarian syndrome (PCOS) is the commonest endocrine disorder in women having wide range of clinical manifestation. These women may present with reproductive, dermatological, metabolic, psychological, or neoplastic implications from adolescence to menopause. The common dermatological manifestations include hirsutism, acne, alopecia, or acanthosis nigricans. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_249_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434760PMC

Endocrine Disrupting Chemicals: Effects on Endocrine Glands.

Front Endocrinol (Lausanne) 2019 21;10:178. Epub 2019 Mar 21.

Endocrinology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

In recent years, endocrine disrupting chemicals have gained interest in human physiopathology and more and more studies aimed to explain how these chemicals compounds affect endocrine system. In human populations, the majority of the studies point toward an association between exposure to endocrine disrupting chemicals and the disorders affecting endocrine axis. A great number of endocrine disrupting chemicals seem to be able to interfere with the physiology of hypothalamus-pituitary-gonadal axis; however, every endocrine axis may be a target for each EDCs and their action is not limited to a single axis or organ. Read More

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http://dx.doi.org/10.3389/fendo.2019.00178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448049PMC

Persistent Metabolic Acidosis on Regular Hemodialysis or Peritoneal Dialysis.

Indian J Nephrol 2019 Mar-Apr;29(2):84-89

Department of Nephrology, JIPMER, Puducherry, India.

Metabolic acidosis is known to have adverse consequences in patients with chronic kidney disease (CKD) including protein-energy wasting, inflammation, bone disease, and disturbance in endocrine function. Unlike in the management of patients with predialysis CKD, bicarbonate levels were not being routinely monitored in dialysis patients at our center. The KDOQI guidelines recommend serum bicarbonate levels ≥22 mEq/L in patients on dialysis. Read More

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http://dx.doi.org/10.4103/ijn.IJN_309_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440337PMC

Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis.

Hepatology 2019 Apr 15. Epub 2019 Apr 15.

Maternal and Fetal Disease Group, Women and Children's Health Division, King's College London, London, SE1 1UL, UK.

Pregnancy is associated with progressive hypercholanemia, hypercholesterolemia and hypertriglyceridemia, which can result in metabolic disease in susceptible women. Gut signals modify hepatic homeostatic pathways, linking intestinal content to metabolic activity. We sought to identify whether enteric endocrine signals contribute to raised serum bile acids observed in human and murine pregnancies, by measuring fibroblast growth factor (FGF)19/15 protein and mRNA levels, and 7α-hydroxy-4-cholesten-3-one. Read More

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http://dx.doi.org/10.1002/hep.30661DOI Listing

Long non-coding RNA H19 is associated with polycystic ovary syndrome in Chinese women: a preliminary study.

Endocr J 2019 Apr 13. Epub 2019 Apr 13.

Department of Obstetrics and Gynecology, the First Clinical Medical College of Jinan University, Guangzhou, Guangdong 510632, China.

Polycystic ovary syndrome (PCOS) represents a serious reproductive and endocrine condition and is associated with high incidence rates. H19 is a compelling long noncoding RNA (lncRNA) which carries out a range of biological functions. However, prior to this study, little was known as to whether there was an association between lncRNA H19 and PCOS. Read More

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http://dx.doi.org/10.1507/endocrj.EJ19-0004DOI Listing

Maternal Roux-en-Y gastric bypass impairs insulin action and endocrine pancreatic function in male F1 offspring.

Eur J Nutr 2019 Apr 13. Epub 2019 Apr 13.

Laboratório de Fisiologia Endócrina e Metabolismo (LAFEM), Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE), Cascavel, PR, 858119-110, Brazil.

Purpose: Obesity is predominant in women of reproductive age. Roux-en-Y gastric bypass (RYGB) is the most common bariatric procedure that is performed in obese women for weight loss and metabolic improvement. However, some studies suggest that this procedure negatively affects offspring. Read More

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http://dx.doi.org/10.1007/s00394-019-01968-9DOI Listing

The kynurenine pathway: a finger in every pie.

Authors:
Jonathan Savitz

Mol Psychiatry 2019 Apr 12. Epub 2019 Apr 12.

Laureate Institute for Brain Research, Tulsa, OK, USA.

The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially increased during an immune response, the KP is a key regulator of the immune system. Perhaps more importantly in the context of psychiatry, many kynurenines are neuroactive, modulating neuroplasticity and/or exerting neurotoxic effects in part through their effects on NMDA receptor signaling and glutamatergic neurotransmission. Read More

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http://www.nature.com/articles/s41380-019-0414-4
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http://dx.doi.org/10.1038/s41380-019-0414-4DOI Listing
April 2019
11 Reads

Sleep and Nutrition Interactions: Implications for Athletes.

Nutrients 2019 Apr 11;11(4). Epub 2019 Apr 11.

Northumbria Centre for Sleep Research, Northumbria University, Newcastle, NE1 8ST, UK.

This narrative review explores the relationship between sleep and nutrition. Various nutritional interventions have been shown to improve sleep including high carbohydrate, high glycaemic index evening meals, melatonin, tryptophan rich protein, tart cherry juice, kiwifruit and micronutrients. Sleep disturbances and short sleep duration are behavioural risk factors for inflammation, associated with increased risk of illness and disease, which can be modified to promote sleep health. Read More

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http://dx.doi.org/10.3390/nu11040822DOI Listing

Apoptosis regulation in adrenocortical carcinoma.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

D Pignatelli, Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Porto, 4099-002, Portugal.

Apoptosis evading is a hallmark of cancer. Tumor cells are characterized by having an impaired apoptosis signaling, a fact that deregulates the balance between cell death and survival, leading to tumor development, invasion and resistance to treatment. In general, patients with adrenocortical carcinomas (ACC) have an extremely bad prognosis, which is related to disease progression and significant resistance to treatments. Read More

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http://dx.doi.org/10.1530/EC-19-0114DOI Listing
April 2019
1 Read

SET domain containing 1B gene (SETD1B) is mutated in primary hepatic neuroendocrine tumors.

Int J Cancer 2019 Apr 11. Epub 2019 Apr 11.

Beijing 302 Hospital/5th Medical Center of Chinese PLA General of Hospital, Beijing 100039, China.

Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare NETs originating from the liver. These tumors are associated with heterogeneous prognosis, and few treatment targets for PHNETs have been identified. Because the major genetic alterations in PHNET are still largely unknown, we performed whole-exome sequencing of 22 paired tissues from PHNET patients and identified 22 recurring mutations of somatic genes involved in the following activities: epigenetic modification (BPTF, MECP2 and WDR5), cell cycle (TP53, ATM, MED12, DIDO1 and ATAD5) and neural development (UBR4, MEN1, GLUL and GIGYF2). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32334
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http://dx.doi.org/10.1002/ijc.32334DOI Listing
April 2019
3 Reads

Associations of serum 25-hydroxyvitamin D with metabolic syndrome and its components in elderly men and women: the Korean Urban Rural Elderly cohort study.

BMC Geriatr 2019 Apr 11;19(1):102. Epub 2019 Apr 11.

Division of Geriatrics, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03772, Republic of Korea.

Background: Many studies have investigated the association between vitamin D and metabolic syndrome (MetS). However, few studies have investigated the association stratified by sex in the elderly. Therefore, we aimed to evaluate the association between vitamin D, MetS, and its components in Korean elderly men and women. Read More

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http://dx.doi.org/10.1186/s12877-019-1118-yDOI Listing
April 2019
1 Read

High concentration of plasma methoxytyramine: dopamine-producing tumour or Parkinson's disease therapy?

Ann Clin Biochem 2019 Apr 11:4563219835263. Epub 2019 Apr 11.

1 Service of Clinical Pharmacology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.

Background: Levodopa (L-DOPA) provided to patients with Parkinson's disease causes an increase in dopamine and methoxytyramine blood concentration which may lead to erroneous diagnosis of dopamine-producing tumours based on a plasma fractionated metanephrines and methoxytyramine assay. Considering that oral L-DOPA is mainly transformed in the gut wall into dopamine and methoxytyramine, we hypothesize that patients treated with L-DOPA produce predominantly sulphated methoxytyramine, whereas dopamine-producing tumours, devoid of sulfotransferase, will secrete free methoxytyramine. These metabolic differences may allow for discrimination between the two groups of patients through methoxytyramine plasma concentration. Read More

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http://dx.doi.org/10.1177/0004563219835263DOI Listing
April 2019
1 Read

Sargassum fusiforme fucoidan modifies the gut microbiota during alleviation of streptozotocin-induced hyperglycemia in mice.

Int J Biol Macromol 2019 Apr 8. Epub 2019 Apr 8.

College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China. Electronic address:

Diabetes is a complicated endocrine and metabolic disorder, which has become an epidemic health issue worldwide. Fucoidan is extensively distributed in the brown algae and several marine invertebrates exhibiting diverse biological activities. In the present study, the physicochemical property of Sargassum fusiforme fucoidan (SFF) and its effects on streptozotocin (STZ)-induced diabetic mice and gut microbiota were investigated. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.040DOI Listing
April 2019
4 Reads

Postnatal early overfeeding induces cardiovascular dysfunction by oxidative stress in adult male Wistar rats.

Life Sci 2019 Apr 8. Epub 2019 Apr 8.

Laboratory of Endocrine Physiology and Metabolism, Federal University of Goiás, Brazil; Neuroscience and Cardiovascular Physiology Research Center, Federal University of Goiás, Brazil. Electronic address:

Aims: Obesity is associated with innumerous comorbidities, including cardiovascular diseases, that occur by various mechanisms, including hyperactivation of the renin angiotensin system, oxidative stress and cardiovascular overload. Postnatal early overfeeding (PO) leads to metabolic imprinting that induces weight gain throughout life, and in this paper, we aimed to evaluate cardiovascular parameters and cardiac molecular changes due to obesity induced early in life by PO.

Main Methods: Male Wistar rats (120-days-old), raised in normal (NL) or small litters (SL), were submitted to cardiac assessment by transthoracic echocardiography and blood pressure evaluation. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.018DOI Listing
April 2019
1 Read

Immune-endocrine interactions related to a high risk of infections in chronic metabolic diseases: The role of PPAR gamma.

Eur J Pharmacol 2019 Apr 8. Epub 2019 Apr 8.

Laboratório de Inflamação, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Avenida Brasil, 4365, Rio de Janeiro, RJ, Brazil. Electronic address:

Diverse disturbances in immune-endocrine circuitries are involved in the development and aggravation of several chronic metabolic diseases (CMDs), including obesity, diabetes, and metabolic syndrome. The chronic inflammatory syndrome observed in CMDs culminates in dysregulated immune responses with low microbial killing efficiency, by means low host innate immune response, and loss of ability to eliminate the pathogens, which results in a high prevalence of infectious diseases, including pneumonia, tuberculosis, and sepsis. Herein, we review evidence pointing out PPARγ as a putative player in immune-endocrine disturbances related to increased risk of infections in CMDs. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.008DOI Listing
April 2019
1 Read

Methodological Quality of Systematic Reviews of Intraoperative Neuromonitoring in Thyroidectomy: A Systematic Review.

JAMA Otolaryngol Head Neck Surg 2019 Apr 11. Epub 2019 Apr 11.

Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

Importance: Systematic reviews and meta-analyses are considered the best evidence for clinical decision making. Many reviews of intraoperative neuromonitoring (IONM) in thyroidectomy have conflicting results, owing in large part to methodological quality.

Objective: To assess the methodological quality and the causes of heterogeneous results of systematic reviews that compare routine IONM vs visual identification of the recurrent laryngeal nerve (RLN) in patients undergoing thyroidectomy. Read More

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http://dx.doi.org/10.1001/jamaoto.2019.0092DOI Listing

Morbidity and mortality of bone metastases in advanced adrenocortical carcinoma: a multicenter retrospective study.

Eur J Endocrinol 2019 May;180(5):311-320

Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, Orbassano, University of Turin, Turin, Italy.

Introduction Adrenocortical carcinoma (ACC) is a rare cancer that commonly spreads to the liver, lungs and lymph nodes. Bone metastases are infrequent. Objective The aim of this report was to describe the clinical characteristics, survival perspective, prognostic factors and frequency of adverse skeletal-related events (SREs) in patients with ACC who developed bone metastasis. Read More

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http://dx.doi.org/10.1530/EJE-19-0026DOI Listing
May 2019
4 Reads

Variants in the BACH2 and CLEC16A gene may be associated with susceptibility to insulin-triggered type 1 diabetes.

J Diabetes Investig 2019 Apr 10. Epub 2019 Apr 10.

Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, To-on, Ehime, Japan.

Aim/introduction: Insulin administration was found to trigger type 1 diabetes (T1D) in six cases of Japanese type 2 diabetes patients (T2D) with T1D high-risk HLA class II (IDDM1) and the class I allele of the insulin gene VNTR genotype (IDDM2). The objective of this study was to assess the contribution of non-HLA single nucleotide polymorphisms (SNPs) to the risk of developing insulin-triggered T1D.

Materials And Methods: We genotyped thirteen T1D susceptible SNPs in the six cases and compared them with those in Japanese controls (Hap Map3-JPT). Read More

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http://dx.doi.org/10.1111/jdi.13057DOI Listing
April 2019
5 Reads

Biomarkers of Endothelial Dysfunction in Women With Polycystic Ovary Syndrome.

Angiology 2019 Apr 10:3319719840091. Epub 2019 Apr 10.

1 First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age. The criteria required for the diagnosis identify various phenotypes, with different reproductive, metabolic, and cardiovascular (CV) risk characteristics. Emerging evidence links adipocyte-secreted hormones as candidates in the pathogenesis of endothelial dysfunction in PCOS, independently of additional risk factors. Read More

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http://dx.doi.org/10.1177/0003319719840091DOI Listing
April 2019
2 Reads

Assessment of Conformational State Transitions of Class B GPCRs Using Molecular Dynamics.

Methods Mol Biol 2019 ;1947:3-19

Department of Chemistry, The University of Vermont, Burlington, VT, USA.

Class B G protein-coupled receptors (GPCRs) comprise a family of 15 peptide-binding members, which are crucial targets for endocrine, metabolic, and stress-related disorders. While their protein structures and dynamics remain largely unclear, computer modeling and simulations represent a promising means to help solve such puzzles. Herein, we present a basic introduction to the methodology of molecular dynamics (MD) simulations and two analytical methods to assess the conformational ensembles and transitions of Class B GPCRs, using our recent studies of the human pituitary adenylate cyclase activating polypeptide (PAC) receptor as an example. Read More

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http://dx.doi.org/10.1007/978-1-4939-9121-1_1DOI Listing
January 2019
1 Read

Intercellular calcium waves integrate hormonal control of glucose output in the intact liver.

J Physiol 2019 Apr 10. Epub 2019 Apr 10.

Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School Rutgers, The State University of New Jersey, Newark, NJ, 07103, USA.

Key Points: Sympathetic outflow and circulating glucogenic hormones both regulate liver function by increasing cytosolic calcium, but how these calcium signals are integrated at the tissue level is currently unknown. We show that stimulation of hepatic nerve fibres or perfusing the liver with physiological concentrations of vasopressin only evoke localized cytosolic calcium oscillations and modest increases in hepatic glucose production. Combining these stimuli acted synergistically to convert localized and asynchronous calcium responses into coordinated intercellular calcium waves that spread throughout the liver lobule and elicited a synergistic increase in hepatic glucose production. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1113/JP277650
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http://dx.doi.org/10.1113/JP277650DOI Listing
April 2019
2 Reads

Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3.

Diabetes Metab J 2019 Apr 8. Epub 2019 Apr 8.

Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.

Background: Protein arginine methyltransferase 1 (PRMT1) is a major enzyme responsible for the formation of methylarginine in mammalian cells. Recent studies have revealed that PRMT1 plays important roles in the development of various tissues. However, its role in pancreas development has not yet been elucidated. Read More

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http://dx.doi.org/10.4093/dmj.2018.0232DOI Listing

The medical treatment with pasireotide in Cushing's disease: an Italian multicentre experience based on "real-world evidence".

Endocrine 2019 Apr 9. Epub 2019 Apr 9.

Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Naples, Italy.

A phase III study has demonstrated that 6-month pasireotide treatment induced disease control with good safety in 15-26% of patients with Cushing's disease (CD). The aim of the current study was to evaluate the 6-month efficacy and safety of pasireotide treatment according to the real-world evidence. Thirty-two CD patients started pasireotide at the dose of 600 µg twice a day (bid) and with the chance of up-titration to 900 µg bid, or down-titration to 450 or 300 µg bid, on the basis of urinary cortisol (UC) levels or safety. Read More

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http://dx.doi.org/10.1007/s12020-018-1818-7DOI Listing

Overview of the Components of Cardiac Metabolism.

Drug Metab Dispos 2019 Apr 9. Epub 2019 Apr 9.

USFDA.

Metabolism in organs other than liver and kidneys may play a significant role in how a specific organ responds to chemicals. The heart has metabolic capability for energy production and homeostasis. This homeostatic machinery can also process xenobiotics. Read More

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http://dx.doi.org/10.1124/dmd.119.086611DOI Listing

Inhibitory effect of Bisphenol A on in vitro feline uterine contractions.

Anim Reprod Sci 2019 Mar 27. Epub 2019 Mar 27.

Kirikkale University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Yahsihan 71450, Kirikkale, Turkey.

Bisphenol A (BPA) is an environmental pollutant used as a plasticizer in the manufacture of many plastic products, such as packaging, containers, and water and beverage bottles. There are deleterious effects of BPA on metabolic, endocrine, nervous, and reproductive systems. This is the first study in which there was investigation of the in vitro effect of BPA on the spontaneous contractions of the cat uterus. Read More

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http://dx.doi.org/10.1016/j.anireprosci.2019.03.017DOI Listing
March 2019
1 Read

Organophosphorus Flame Retardants Impair Intracellular Lipid Metabolic Function in Human Hepatocellular Cells.

Chem Res Toxicol 2019 Apr 18. Epub 2019 Apr 18.

College of Life Science , Zhejiang Chinese Medical University , Hangzhou 310053 , Zhejiang People's Republic of China.

Organophosphorus flame retardants (OPFRs), a replacement for brominated flame retardants, have gradually been accepted as endocrine disrupting chemicals (EDCs). Recently, evidence has shown that these EDCs could cause chronic health problems, such as obesity, and referred to as metabolic disruptors. However, the disturbance to lipid metabolism caused by OPFRs remains poorly understood, especially at biological molecular levels. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.9b00058DOI Listing
April 2019
1 Read

Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase.

J Steroid Biochem Mol Biol 2019 Apr 6. Epub 2019 Apr 6.

Institute of Pharmacy / Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria; Department of Medicinal and Pharmaceutical Chemistry, Institute of Pharmacy, Paracelsus Medical University, Strubergasse 22, 5020, Salzburg, Austria. Electronic address:

Humans are constantly exposed to a multitude of environmental chemicals that may disturb endocrine functions. It is crucial to identify such chemicals and uncover their mode-of-action to avoid adverse health effects. 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) catalyze the formation of cortisol and aldosterone, respectively, in the adrenal cortex. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.04.007DOI Listing
April 2019
2 Reads

The use of Medical Identification Jewellery in Adults with Adrenal Insufficiency in Australia.

Clin Endocrinol (Oxf) 2019 Apr 9. Epub 2019 Apr 9.

Endocrine and Metabolic Unit, Royal Adelaide Hospital and University of Adelaide, North Terrace, Adelaide, SA, 5000, Australia.

Objective: Hydrocortisone stress dosing during illness can prevent adrenal crises (AC) in patients with adrenal insufficiency (AI). When patients cannot communicate, medical identification jewellery may facilitate parenteral hydrocortisone provision but patient adoption rates are not known.

Design: A cross-sectional analysis of Australian medical identification jewellery subscription data. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13985
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http://dx.doi.org/10.1111/cen.13985DOI Listing
April 2019
4 Reads

The next step after anti-osteoporotic drug discontinuation: an up-to-date review of sequential treatment.

Endocrine 2019 Apr 8. Epub 2019 Apr 8.

Endocrinology and Nutrition Unit, Hospital Universitario San Cecilio de Granada, Department of Medicine, University of Granada, Granada, Spain.

Several antiresorptive drugs, like bisphosphonates and denosumab, are currently available for the treatment of osteoporosis due to their evidenced efficacy in reducing fracture risk at mid-term. Osteoanabolic therapies, like teriparatide, whose treatment duration is limited to 2 years, have also shown efficacy in the reduction of fracture risk. However, depending on the severity of osteoporosis and the presence of other associated risk factors for fracture, some patients may require long-term treatment to preserve optimal bone strength and minimize bone fracture risk. Read More

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http://dx.doi.org/10.1007/s12020-019-01919-8DOI Listing
April 2019
1 Read

DNA Methylation in the Pathogenesis of Polycystic Ovary Syndrome.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

M Cerbón, Faculty of Chemistry, National autonomous University of Mexico, D.F., Mexico.

Polycystic ovary syndrome (PCOS) is the leading endocrine and metabolic disorder in premenopausal women characterized by hyperandrogenism and abnormal development of ovarian follicles. To date, the PCOS etiology remains unclear and has been related to insulin resistance, obesity, type 2 diabetes mellitus, cardiovascular disease, and infertility, among other morbidities. Substantial evidence illustrates the impact of genetic, intrauterine, and environmental factors on the PCOS etiology. Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0449DOI Listing
April 2019
9 Reads

Leptin resensitization: a reversion of leptin resistant states.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

M Perello, Laboratory of Neurophysiology, Instituto Multidisciplinario de Biologia Celular, La Plata, Argentina.

Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. It is closely associated with obesity, and also observed in physiological situations such as pregnancy and in seasonal animals. Leptin resensitization refers to the reversion of leptin resistant states and is associated with improvement in endocrine and metabolic disturbances commonly observed in obesity and a sustained decrease of plasma leptin levels, possibly below a critical threshold level. Read More

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http://dx.doi.org/10.1530/JOE-18-0606DOI Listing

Circadian Control of Neuroendocrine Function: Implications for Health and Disease.

Curr Opin Physiol 2018 Oct 15;5:133-140. Epub 2018 Nov 15.

Department of Psychology, University of California, Berkeley, CA, 94720.

The circadian timing system orchestrates daily rhythms in physiology and behavior via the suprachiasmatic nucleus (SCN), the master brain clock. Because endocrine secretions have far-reaching influence on the brain and periphery, circadian regulation of hormones is essential for normal functioning and disruptions to circadian timing (e.g. Read More

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http://dx.doi.org/10.1016/j.cophys.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446932PMC
October 2018
1 Read

Imaging mass spectrometry enables molecular profiling of mouse and human pancreatic tissue.

Diabetologia 2019 Apr 6. Epub 2019 Apr 6.

9160 MRB III, Department of Biochemistry, Vanderbilt University, Nashville, TN, 37232, USA.

Aims/hypothesis: The molecular response and function of pancreatic islet cells during metabolic stress is a complex process. The anatomical location and small size of pancreatic islets coupled with current methodological limitations have prevented the achievement of a complete, coherent picture of the role that lipids and proteins play in cellular processes under normal conditions and in diseased states. Herein, we describe the development of untargeted tissue imaging mass spectrometry (IMS) technologies for the study of in situ protein and, more specifically, lipid distributions in murine and human pancreases. Read More

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http://dx.doi.org/10.1007/s00125-019-4855-8DOI Listing

Hindbrain estrogen receptor regulation of ventromedial hypothalamic glycogen metabolism and glucoregulatory transmitter expression in the hypoglycemic male rat.

Neuroscience 2019 Apr 5. Epub 2019 Apr 5.

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, United States of America. Electronic address:

Estrogen receptor-alpha (ERα) and -beta (ERβ) occur in key elements of the brain gluco-homeostatic network in both sexes, including the hindbrain dorsal vagal complex (DVC), but the influence of distinct receptor populations on this critical function is unclear. The ventromedial hypothalamic nucleus (VMN) maintains glucose balance by integrating nutrient, endocrine, and neurochemical cues, including metabolic sensory information supplied by DVC A2 noradrenergic neurons. Current research utilized the selective ERα and ERβ antagonists MPP and PHTPP to characterize effects of DVC ERs on VMN norepinephrine (NE) activity and metabolic neurotransmitter signaling in insulin-induced hypoglycemic (IIH) male rats. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.03.053DOI Listing
April 2019
1 Read

Serelaxin (recombinant human relaxin-2) treatment affects the endogenous synthesis of long chain poly-unsaturated fatty acids and induces substantial alterations of lipidome and metabolome profiles in rat cardiac tissue.

Pharmacol Res 2019 Apr 5;144:51-65. Epub 2019 Apr 5.

Cellular and Molecular Cardiology Unit and Department of Cardiology, Institute of Biomedical Research (IDIS-SERGAS), Travesía Choupana s/n, 15706 Santiago de Compostela, Spain; CIBERCV, Institute of Health Carlos III, C/ Monforte de Lemos 3-5, Pabellón 11. Planta 0, 28029 Madrid, Spain.

Background And Purpose: Recombinant human relaxin-2, serelaxin, is being proved as a novel drug with therapeutic efficacy in some cardiovascular diseases, especially heart failure, a disease whose physiopathology and course are firmly correlated with important alterations in cardiac metabolism. The aim of our present work was to investigate changes in the cardiac metabolome following relaxin-2 treatment.

Experimental Approach: Sprague-Dawley rats were treated with human recombinant relaxin-2 using osmotic minipumps at a dose of 0. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.04.009DOI Listing
April 2019
2 Reads