552,662 results match your criteria Endocrine Metabolic & Immune Disorders - Drug Targets[Journal]


Bisphenol F causes disruption of gonadotropin-releasing hormone neural development in zebrafish via an estrogenic mechanism.

Neurotoxicology 2018 Dec 3. Epub 2018 Dec 3.

Department of Biology, Neuroscience Program, University of Puget Sound, Tacoma, Washington, USA. Electronic address:

Gonadotropin releasing hormone (GnRH) neurons in the brain are the main controllers of reproduction and reproductive behavior in most vertebrates, and are susceptible to endocrine disruption by different bisphenols. While the endocrine disrupting properties of bisphenol A have been well documented, commonly used analogues such as bisphenol F (BPF) are not as well studied. In this study we examined the effects of early, low-dose, chronic BPF exposure on the development of the GnRH neural system in the zebrafish embryo. Read More

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December 2018

Socioeconomic disparities in a population of patients undergoing total thyroidectomy for benign disease.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.

Background: This study examines the effect of insurance status (as a measure of socioeconomic status) on patient with benign thyroid disease.

Methods: A retrospective review was performed among 60 patients undergoing total thyroidectomy for benign thyroid disease. Univariate and multivariable analyses examined the relationship between insurance status and thyroid volume (sum of the left and right lobe volumes). Read More

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December 2018

Unexpected discrepancies in hospital administrative databases can impact the accuracy of monitoring thyroid surgery outcomes in France.

PLoS One 2018 6;13(12):e0208416. Epub 2018 Dec 6.

Department of General and Endocrine Surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.

Objective: To determine the validity of hospital administrative databases compared to prospective collection of medical data assessing thyroid surgery complications.

Background: Administrative data are increasingly used to track surgical outcomes.

Methods: All patients undergoing thyroid surgery at three French university hospitals between April 2008 and April 2009 were prospectively included. Read More

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December 2018
1 Read

Inflammatory and Infectious Syndromes Associated with Cancer Immunotherapies.

Clin Infect Dis 2018 Dec 6. Epub 2018 Dec 6.

Department of Medicine, Harvard Medical School, Boston, MA, USA.

Immunotherapy using antibodies to immune checkpoint molecules or targeted chimeric antigen receptor-modified T (CAR-T) cells represent dramatic advances in cancer treatment. These therapies mediate immune-related adverse events (irAEs) which may mimic or amplify infectious presentations. Checkpoint inhibitor therapy may be associated with diverse irAEs including mild skin, endocrine and autoimmune manifestations or severe inflammatory processes including colitis, pneumonitis, myocarditis, and shock. Read More

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December 2018
2 Reads

Glomerular filtration rate: when to measure and in which patients?

Nephrol Dial Transplant 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Dialysis, Transplantation, University of Liège (CHU ULg), Liège, Belgium.

Of the glomerular, tubular and endocrine functions of the kidney, nephrologists have mostly focused their attention on the glomerular functions-albuminuria and glomerular filtration rate (GFR)-to grade the severity of chronic kidney disease (CKD). Although both albuminuria and GFR are associated with renal and cardiovascular morbidity and mortality, the utility of measured GFR (mGFR) has been questioned. GFR when measured adequately is the most precise measure of glomerular function and can be useful to individualize therapy among patients with CKD. Read More

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December 2018
2 Reads

Cyclin-dependent kinase 4/6 inhibitors: what have we learnt across studies, therapy situations and substances.

Curr Opin Obstet Gynecol 2018 Dec 5. Epub 2018 Dec 5.

Department of Gynecology and Obstetrics, Regio Klinikum Pinneberg, Pinneberg, Germany.

Purpose Of Review: Cyclin-dependent kinases (CDK) are key regulatory enzymes that control cell cycle and cell division. In the recent years, new therapeutic options selectively targeting CDK 4 and 6 have shown promising clinical activity in several solid tumors. Since 2015, three CDK 4/6 inhibitors have been approved for treatment of hormone receptor-positive HER2-negative metastatic breast cancer: palbociclib, ribociclib and abemaciclib. Read More

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December 2018

Assessing the population relevance of endocrine disrupting effects for non-target vertebrates exposed to plant protection products.

Integr Environ Assess Manag 2018 Dec 6. Epub 2018 Dec 6.

Corteva AgriscienceTM, Agriculture Division of DowDuPontTM, 3B Park Square, Milton Park, Abingdon, Oxfordshire, OX14 4RN, UK.

The European Commission intends to protect vertebrate wildlife populations by regulating Plant Protection Product (PPP) active substances that have endocrine disrupting properties with a hazard-based approach. In this paper we consider how the Commission's hazard-based Regulation and accompanying Guidance can be operationalised to ensure that a technically robust process is used to distinguish between substances with adverse population level effects and those for which it can be demonstrated that adverse effects observed (typically in the laboratory) do not translate into adverse effects at the population level. Our approach is to use population models within the adverse outcome pathway framework to link the non-linear relationship between adverse effects at the individual and population levels in the following way: (1) Use Specific Protection Goals for focal wildlife populations within an ecosystem services framework; (2) Model the effects of changes in population-related inputs on focal species populations using individual-based population models to determine thresholds between negligible and non-negligible (i. Read More

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December 2018
1 Read

Effect of sex hormone-binding globulin polymorphisms on the outcome of in vitro fertilization-embryo transfer for polycystic ovary syndrome patients: A case-control study.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Gynecology, Linyi People's Hospital, Linyi, China.

Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone-binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization-embryo transfer (IVF-ET) in PCOS patients. PCOS patients who underwent IVF-ET and patients with non-PCOS-related infertility were selected in the study. Read More

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December 2018
1 Read

Italian consensus for the classification and reporting of thyroid cytology: the risk of malignancy between indeterminate lesions at low or high risk. A systematic review and meta-analysis.

Endocrine 2018 Dec 5. Epub 2018 Dec 5.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Background: Italian consensus for the classification and reporting of thyroid cytology has proposed to discriminate the cancer prevalence of high (Tir 3B) vs. low (Tir 3A) risk indeterminate nodules. To obtain more robust evidence on this topic, we performed a meta-analysis of the Odds Ratio (OR) of malignancy of Tir 3B vs. Read More

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December 2018
2 Reads

How radical is total parathyroidectomy in patients with renal hyperparathyroidism?

Langenbecks Arch Surg 2018 Dec 5. Epub 2018 Dec 5.

Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Waehringer Gürtel 18-20, A-1090, Vienna, Austria.

Purpose: Total parathyroidectomy (tPTX) in patients with renal hyperparathyroidism (RHPT) aims at the complete removal of all hyperfunctioning parathyroid tissue. Whenever parathyroidectomy is termed "total," undetectable postoperative parathyroid hormone (PTH) levels within the first postoperative week are expected. The aim of this study was to evaluate if tPTX is technically possible using a radical surgical procedure. Read More

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December 2018

Perfluorinated compounds binding to estrogen receptor of different species: a molecular dynamic modeling.

J Mol Model 2018 Dec 5;25(1). Epub 2018 Dec 5.

School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.

Perfluorinated compounds (PFCs) were widely utilized in commercial and industrial applications, which could interfere with the endocrine systems of experimental animals and humans by interacting with estrogen receptors (ERs). Considering the possible differential binding preferences and relative binding affinities of PFCs to ERs of humans and other species, a cross-species comparison is necessary to effectively assess the health risk of PFCs to humans. In the present work, the species-specific binding characterizations between two PFCs, including perfluorooctane sulfonate (PFOS) and PFOS(4m, 5m), and the different ERαs from Rattus norvegicus, rainbow trout, and humans were explored based on a molecular dynamic modeling. Read More

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December 2018

Identification of Five Genes as a Potential Biomarker for Predicting Progress and Prognosis in Adrenocortical Carcinoma.

J Cancer 2018 31;9(23):4484-4495. Epub 2018 Oct 31.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.

Background: Adrenocortical carcinoma (ACC) is a limited endocrine fatality with a minor diagnosis and rare remedial options. The progressive and predictive meaning of message RNA (mRNA) expression oddity in ACC has been studied extensively in recent years. However, differences in measurement platforms and lab protocols as well as small sample sizes can render gene expression levels incomparable. Read More

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October 2018
2 Reads

Efficacy of CapeOX plus Cetuximab Treatment as a First-Line Therapy for Patients with Extended RAS/BRAF/PIK3CA Wild-Type Advanced or Metastatic Colorectal Cancer.

J Cancer 2018 18;9(22):4092-4098. Epub 2018 Oct 18.

Kitakyushu General Hospital, Kitakyushu, Japan.

Oxaliplatin and capecitabine (CapeOX) combined with cetuximab is rarely used to treat advanced and metastatic colorectal cancer (mCRC). The present study aimed to clarify the clinical benefits of this treatment regimen when used as a first-line therapy in patients with expanded RAS/BRAF/PIK3CA wild-type mCRC, using the data and tumor specimens from two previously published Phase II clinical trials. The gene mutation status and clinical data of 102 patients with KRAS wild-type mCRC, who received either of CapeOX + cetuximab or FOLFOX + cetuximab, were analyzed. Read More

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October 2018

Analysis of Lipid Metabolism, Immune Function, and Neurobehavior in Adult C57BL/6JxFVB Mice After Developmental Exposure to di (2-ethylhexyl) Phthalate.

Front Endocrinol (Lausanne) 2018 21;9:684. Epub 2018 Nov 21.

Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands.

Developmental exposure to di (2-ethylhexyl) phthalate (DEHP) has been implicated in the onset of metabolic syndrome later in life. Alterations in neurobehavior and immune functions are also affected by phthalate exposure and may be linked to the metabolic changes caused by developmental exposure to DEHP. Our goal was to study the effects of developmental exposure to DEHP in the context of metabolic syndrome by integrating different parameters to assess metabolic, neurobehavioral, and immune functions in one model. Read More

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November 2018
3 Reads

Long noncoding RNA H19 mediated the chemosensitivity of breast cancer cells via Wnt pathway and EMT process.

Onco Targets Ther 2018 9;11:8001-8012. Epub 2018 Nov 9.

Department of Internal Medicine,

Background: Breast cancer is still one of the major public health burdens worldwide, although there is tremendous progress in early diagnosis and treatment of breast cancer. Tamoxifen was one of the most popular endocrine therapies for early-stage estrogen receptor (ER) + breast cancer patients. However, a high incidence of drug resistance develops along with poor prognosis in breast cancer. Read More

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November 2018

Parathyroid hormone induces a browning program in human white adipocytes.

Int J Obes (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.

Energy dissipation through the promotion of brown adipose tissue (BAT) or browning of white adipose tissue has recently evolved as novel promising concept in the fight against metabolic disease. New evidence suggests that hormones can contribute to the thermogenic programming of adipocytes through paracrine or endocrine actions. Recent studies in rodents identified parathyroid hormone (PTH) and PTH-related peptide as mediators of energy wasting in cachexia models due to adipocyte browning. Read More

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December 2018

Serotonin receptors of 5-HT2 type in the hypothalamic arcuate nuclei (ARC) positively regulate liver cytochrome P450 via stimulation of the growth hormone-releasing hormone - growth hormone (GHRH-GH) hormonal pathway.

Drug Metab Dispos 2018 Dec 5. Epub 2018 Dec 5.

Institute of Pharmacology, Polish Academy of Sciences

Our recent study carried out after local injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine into the arcuate nuclei (ARC) of the hypothalamus suggested a positive influence of the serotonergic innervation of the ARC on growth hormone secretion and growth hormone-dependent expression of cytochrome P450. The aim of our present study was to determine the effect of the activation of the 5-HT1 or 5-HT2 type receptors in the ARC on the expression and activity of cytochrome P450 in the liver of male rats. The serotonergic agonists 5-CT (5-carboxyamidotryptamine, a 5-HT1 type receptor agonist) or DOI (2,5-dimethoxy-4-iodoamphetamine, a 5-HT2 type receptor agonist) were injected into the ARC for 5 days. Read More

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December 2018
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Cumulative network-meta-analyses, practice guidelines and actual prescriptions of drug treatments for postmenopausal osteoporosis: a study protocol for cumulative network meta-analyses and meta-epidemiological study.

BMJ Open 2018 Dec 4;8(12):e023218. Epub 2018 Dec 4.

Department of Health Promotion and Human Behavior, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Introduction: Cumulative network meta-analysis (NMA) is a method to provide a global comparison of multiple treatments with real-time update to evidence users. Several studies investigated the ranking of cumulative NMA and the recommendations of practice guidelines. However, to the best of our knowledge, no study has evaluated the cumulative NMA ranking and prescription patterns. Read More

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December 2018
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A phase 1b dose-escalation and expansion study of the BCL-2 inhibitor venetoclax combined with tamoxifen in ER and BCL-2-positive metastatic breast cancer.

Cancer Discov 2018 Dec 5. Epub 2018 Dec 5.

Stem Cells and Cancer Division, The Walter and Eliza Hall Institute.

Venetoclax, a potent and selective BCL-2 inhibitor, synergizes with endocrine therapy in pre-clinical models of ER-positive breast cancer. Using a phase 1b 3+3 dose escalation and expansion study design, 33 patients with ER and BCL-2-positive metastatic disease (mean prior regimens, 2; range 0-8) were treated with daily tamoxifen (20 mg) and venetoclax (200-800 mg). Apart from uncomplicated 'on-target' lymphopenia, no dose-limiting toxicities or high-grade adverse events were observed in the escalation phase (15 patients), and 800 mg was selected as the recommended phase 2 dose (RP2D). Read More

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December 2018

Tissue-specific Accumulation and Body Burden of Parabens and Their Metabolites in Small Cetaceans.

Environ Sci Technol 2018 Dec 5. Epub 2018 Dec 5.

Parabens have been of global concern due to their endocrine disrupting properties. However, few studies have reported tissue-specific distribution of parabens in wildlife. In this study, we measured parabens and their metabolites in organs and tissues (blubber, muscle, melon, stomach, kidney, liver, gonad, brain, uterus, and umbilical cord, total n=94) of common dolphins (Delphinus capensis) and finless porpoises (Neophocaena asiaeorientalis), to investigate tissue-specific accumulation and body burden. Read More

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December 2018

[Systemic Treatment of Early and Metastatic Breast Cancer].

Dtsch Med Wochenschr 2018 Dec 3;143(24):1751-1754. Epub 2018 Dec 3.

Klinik und Poliklinik für Gynäkologie, Universitätsklinikum Hamburg-Eppendorf.

Within the last years significant improvements have been achieved in early and metastatic breast cancer treatment by innovative targeted therapies and new drug combinations. GnRH-analogues have been confirmed as an important part of endocrine treatment in premenopausal patients. Endocrine based strategies including CDK-4/6-Inhibitors substantially improve progression-free survival in metastatic patients. Read More

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December 2018

Mesenchymal stem cells to treat type 1 diabetes.

Authors:
John S Pixley

Biochim Biophys Acta Mol Basis Dis 2018 Nov 30. Epub 2018 Nov 30.

Division of Rheumatology/Immunology, Department of Medicine, Texas Tech University Health Science Center, 3601 4th Street, MS 9410, Lubbock, TX 79430, USA. Electronic address:

What is clear is we are in the era of the stem cell and its potential in ameliorating human disease. Our perspective is generated from an in vivo model in a large animal that offers significant advantages (complete transplantation tolerance, large size and long life span). This review is an effort to meld our preclinical observations with others for the reader and to outline potential avenues to improve the present outlook for patients with diabetes. Read More

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November 2018

Biphasic effects of perfluorooctanoic acid on steroidogenesis in mouse Leydig tumour cells.

Reprod Toxicol 2018 Nov 30. Epub 2018 Nov 30.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China. Electronic address:

Perfluorooctanoic acid (PFOA) is a persistent organic pollutant, which may possess endocrine disrupting properties. Herein, we investigated the possible mechanism(s) of toxicity and steroidogenesis in mouse Leydig cells. MLTC-1 (mouse Leydig tumour cells) cells were exposed to 0, 50, 100 or 200 μM PFOA for 48 h to ascertain their effects on the nuclear (membrane) receptor responses, steroidogenesis pathway and related regulated gene expression and steroid hormone secretion profiles. Read More

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November 2018
2 Reads

Chromosomal microarray and whole exome sequencing identify genetic causes of congenital hypothyroidism with extra-thyroidal congenital malformations.

Clin Chim Acta 2018 Nov 30. Epub 2018 Nov 30.

Department of Genetic Metabolism, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, People's Republic of China. Electronic address:

Background: Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder. Although most patients present with isolated CH, some patients present with CH and extra-thyroidal congenital malformations (ECMs), for which less is known about the underlying genetics. The aim of this study was to investigate the genetic mechanisms in patients with CH and ECMs using chromosomal microarray (CMA) and whole exome sequencing (WES). Read More

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November 2018

Aromatase inhibitor therapy for endometrial stromal sarcoma - two-centre experience.

Ginekol Pol 2018 ;89(11):607-610

Department of Oncology and Radiotherapy, Medical University of Gdansk, Poland.

Objectives: Endocrine therapy is the recommended systemic treatment for steroid receptor positive endometrial stromal sarcoma (ESS). There is no current consensus on the optimal hormonal therapy for ESS. The literature offers several reports on advanced/recurrent/metastatic ESS patients treated with progestins, whereas data on the efficacy of aromatase inhibitors are scarce. Read More

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January 2018

Endocrine aspects of Klinefelter syndrome.

Curr Opin Endocrinol Diabetes Obes 2018 Nov 30. Epub 2018 Nov 30.

Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Klinefelter syndrome is the most common sex chromosome abnormality in men. Hypogonadism and testicular degeneration are almost universal. Truncal adiposity, metabolic syndrome and low bone mass occur frequently. Read More

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November 2018

Characterization of thoracal fat depots - expression of adipokines and remodeling factors and impact of adipocyte conditioned media in fibroblast scratch assays.

Clin Hemorheol Microcirc 2018 ;70(3):267-280

Department of Cardiac Surgery, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Herzzentrum Dresden, Germany.

Adipose tissue is not only a connective tissue but also an endocrine organ secreting adipokines like Leptin and Adiponectin, lipokines such as palmitoileic acid and extracellular vesicles. These factors and the expression of matrix remodeling enzymes impact surrounding tissues via paracrine effects. The expression of selected secretion factors and the effect of adipocyte conditioned media from four thoracal adipose tissue origins - subcutaneous, perivascular, pericardial and epicardial adipose tissues - in a fibroblast proliferation/wound healing scratch assay model were investigated. Read More

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January 2018

Biocatalytic Degradation of Parabens Mediated by Cell Surface Displayed Cutinase.

Authors:
Baotong Zhu Na Wei

Environ Sci Technol 2018 Dec 3. Epub 2018 Dec 3.

Parabens are emerging environmental contaminants with known endocrine-disrupting effects. This study created a novel biocatalyst (named as SDFsC) by expressing the enzyme Fusarium solani pisi cutinase (FsC) on the cell surface of Baker's yeast Sacchromyces cerevisiae and demonstrated successful enzyme-mediated removal of parabens for the first time. Parabens with different side chain structures had different degradation rates by the SDFsC. Read More

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December 2018

Total circulating cell-free miRNA in plasma as a predictive biomarker of the thyroid diseases.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Vocational Health College, Canakkale Onsekiz Mart University, Canakkale, Turkey.

Background: Thyroid cancer is a common endocrine cancer. Great progress has been made in resolving its molecular mechanisms in recent years. The molecular changes observed in thyroid cancer can be used as biomarkers for diagnostic, prognostic and therapeutic purposes. Read More

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December 2018
1 Read

Association of the human aryl hydrocarbon receptor repressor (AhRR)-c.565C>G transversion with male infertility: A case-control study from Iran.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran.

Dioxins (eg, 2,3,7,8-tetrachlorodibenzo-p-dioxin/TCDD), as environmental endocrine disruptors and toxic carcinogens, can affect male reproductive health. The influence of dioxins is mediated via the aryl hydrocarbon receptor (AhR) pathway and its repressor (AhRR). In this study, we investigated the association of AhRR-c. Read More

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December 2018

High-performance thin-layer chromatography coupled with HPLC-DAD/HPLC-MS/MS for simultaneous determination of bisphenol A and nine brominated analogs in biological samples.

Anal Bioanal Chem 2018 Dec 1. Epub 2018 Dec 1.

CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, Shandong, China.

Bisphenol A (BPA) and its brominated analogs exhibiting bioaccumulation potential, endocrine disruption, and reproductive toxicity have been worldwide detected in water, air, soil, and sediments. But few methods have been proposed for simultaneously determining a variety of these compounds in biological matrices, hindering the further study on their biological transformation/degradation and health risks. In this study, a simple, solvent-saving and sensitive method based on high-performance thin-layer chromatography (HPTLC) for sample pretreatment coupled with high-performance liquid chromatography-diode array detector (HPLC-DAD) (UV = 214 nm)/triple quadrupole mass spectrometry (MS/MS) was developed for determining BPA and its nine brominated analogs in biological samples. Read More

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December 2018
3.436 Impact Factor

Carbon dioxide absorption during retroperitoneoscopic adrenalectomy: comparison between monolateral and synchronous bilateral approaches.

Updates Surg 2018 Dec 1. Epub 2018 Dec 1.

Department of Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Synchronous posterior retroperitoneoscopic bilateral adrenalectomy (PR-BilA) is a novel technique proposed for the definitive cure of hypercortisolism when a surgical approach is indicated. The aim of the present prospective cohort study was to compare the carbon dioxide (CO) absorption in patients undergoing PR-BilA with those undergoing single posterior retroperitoneoscopic adrenalectomy (PRA). Twenty-nine patients undergoing PR-BilA or PRA were consecutively enrolled. Read More

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December 2018

Prediction of therapy response in bone-predominant metastatic breast cancer: comparison of [F] fluorodeoxyglucose and [F]-fluoride PET/CT with whole-body MRI with diffusion-weighted imaging.

Eur J Nucl Med Mol Imaging 2018 Dec 1. Epub 2018 Dec 1.

Cancer Imaging Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.

Purpose: To compare [F]-fluorodeoxyglucose (FDG) and [F]-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) with whole-body magnetic resonance with diffusion-weighted imaging (WB-MRI), for endocrine therapy response prediction at 8 weeks in bone-predominant metastatic breast cancer.

Patients And Methods: Thirty-one patients scheduled for endocrine therapy had up to five bone metastases measured [FDG, NaF PET/CT: maximum standardized uptake value (SUV); WB-MRI: median apparent diffusion coefficient (ADC)] at baseline and 8 weeks. To detect the flare phenomenon, a 12-week NaF PET/CT was also performed if 8-week SUV increased. Read More

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December 2018

Therapy of moderate-to-severe Graves' orbitopathy with intravenous methylprednisolone pulses is not associated with loss of bone mineral density.

Endocrine 2018 Dec 1. Epub 2018 Dec 1.

Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland.

Purpose: To evaluate the influence of intravenous methylprednisolone (IVMP) pulse administration on bone mineral density (BMD) of the lumbar spine and the femoral neck in patients with moderate-to-severe Graves' orbitopathy (GO).

Methods: Thirty-five patients with GO in euthyreosis were treated with 12 IVMP pulses (6 × 0.5 g, 6 × 0. Read More

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December 2018

Correction to: Anti-Müllerian hormone serum levels in systemic lupus erythematosus patients: influence of the disease severity and therapy on the ovarian reserve.

Endocrine 2018 Dec 1. Epub 2018 Dec 1.

Institute of Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy.

The original version of this article unfortunately contained a mistake in given and family names of all the authors. Read More

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December 2018

Correction to: People with diabetes do not learn and recall their diabetes foot education: a cohort study.

Endocrine 2018 Nov 30. Epub 2018 Nov 30.

Monash Health, Allied Health Research Unit, Kingston Centre, Warrigal Rd, Cheltenham, VIC, 3192, Australia.

The original version of this article unfortunately contained an mistake in country name in all the affiliations. The county name was inadvertently published as USA, it should be Australia instead. The affiliations are corrected in this erratum. Read More

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November 2018

Extended duration of adjuvant aromatase inhibitor in breast cancer: a meta-analysis of randomized controlled trials.

Gland Surg 2018 Oct;7(5):449-457

Breast and Endocrine Surgery Unit, Royal Adelaide Hospital, Adelaide, Australia.

Background: The risk of hormone positive breast cancer extends beyond 5 years. Extended duration of tamoxifen to 10 years has been shown to improve overall survival (OS) and disease-free survival (DFS). In post-menopausal women aromatase inhibitor (AI) is the gold standard for adjuvant endocrine therapy. Read More

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October 2018

Acute non-traumatic adrenal haemorrhage-management, pathology and clinical outcomes.

Gland Surg 2018 Oct;7(5):428-432

Endocrine Surgery Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Background: Acute adrenal haemorrhage is a rare medical emergency. The aim of the series was to study the clinical presentation and management of patients presenting with acute non-traumatic adrenal haemorrhage.

Methods: The records of patients presenting with an acute abdomen secondary to adrenal haemorrhage and treated in a tertiary endocrine surgical unit over a period of 6 years were reviewed. Read More

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October 2018
1 Read

Particulate Matter Air Pollution: Effects on the Cardiovascular System.

Front Endocrinol (Lausanne) 2018 16;9:680. Epub 2018 Nov 16.

Section of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Chicago, Chicago, IL, United States.

Air pollution is a complex mixture of gaseous and particulate components, each of which has detrimental effects on human health. While the composition of air pollution varies greatly depending on the source, studies from across the world have consistently shown that air pollution is an important modifiable risk factor for significantly increased morbidity and mortality. Moreover, clinical studies have generally shown a greater impact of particulate matter (PM) air pollution on health than the gaseous components. Read More

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November 2018

Involvement of Glucagon in Preventive Effect of Menthol Against High Fat Diet Induced Obesity in Mice.

Front Pharmacol 2018 16;9:1244. Epub 2018 Nov 16.

National Agri-Food Biotechnology Institute, Sahibzada Ajit Singh Nagar, India.

Glucagon mediated mechanisms have been shown to play clinically significant role in energy expenditure. The present study was designed to understand whether pharmacological mimicking of cold using menthol (TRPM8 modulator) can induce glucagon-mediated energy expenditure to prevent weight gain and related complications. Acute oral and topical administration of TRPM8 agonists (menthol and icilin) increased serum glucagon concentration which was prevented by pre-treatment with AMTB, a TRPM8 blocker. Read More

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November 2018

A big data approach with artificial neural network and molecular similarity for chemical data mining and endocrine disruption prediction.

Indian J Pharmacol 2018 Jul-Aug;50(4):169-176

Department of Biotechnology, Liatris Biosciences LLP, Kottayam, Kerala, India.

Context: Chemical toxicity prediction at early stage drug discovery phase has been researched for years, and newest methods are always investigated. Research data comprising chemical physicochemical properties, toxicity, assay, and activity details create massive data which are becoming difficult to manage. Identifying the desired featured chemical with the desired biological activity from millions of chemicals is a challenging task. Read More

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December 2018

Modelling the endocrine pancreas in health and disease.

Nat Rev Endocrinol 2018 Nov 30. Epub 2018 Nov 30.

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany.

Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss or dysfunction of pancreatic β-cells, but the pathomechanisms underlying β-cell failure in type 1 diabetes mellitus and type 2 diabetes mellitus are still poorly defined. Regeneration of β-cell mass from residual islet cells or replacement by β-like cells derived from stem cells holds great promise to stop or reverse disease progression. Read More

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November 2018

Gut microbiota and inflammation in chronic kidney disease and their roles in the development of cardiovascular disease.

Hypertens Res 2018 Nov 30. Epub 2018 Nov 30.

Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey.

The health and proper functioning of the cardiovascular and renal systems largely depend on crosstalk in the gut-kidney-heart/vessel triangle. Recent evidence suggests that the gut microbiota has an integral function in this crosstalk. Mounting evidence indicates that the development of chronic kidney and cardiovascular diseases follows chronic inflammatory processes that are affected by the gut microbiota via various immune, metabolic, endocrine, and neurologic pathways. Read More

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November 2018
1 Read

Adipocyte OGT governs diet-induced hyperphagia and obesity.

Nat Commun 2018 Nov 30;9(1):5103. Epub 2018 Nov 30.

Program in Integrative Cell Signaling and Neurobiology of Metabolism and Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.

Palatable foods (fat and sweet) induce hyperphagia, and facilitate the development of obesity. Whether and how overnutrition increases appetite through the adipose-to-brain axis is unclear. O-linked beta-D-N-acetylglucosamine (O-GlcNAc) transferase (OGT) couples nutrient cues to O-GlcNAcylation of intracellular proteins at serine/threonine residues. Read More

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November 2018

miR-10b Downregulated by DNA Methylation Acts as a Tumor Suppressor in HPV-Positive Cervical Cancer via Targeting Tiam1.

Cell Physiol Biochem 2018 Nov 30;51(4):1763-1777. Epub 2018 Nov 30.

Comprehensive Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou,

Background/aims: microRNAs (miRNAs) are known to act as oncogenes or tumor suppressors in diverse cancers. Although miR-10b is an oncogene implicated in many tumors, its role in cervical cancer (CC) remains largely unclear. Here, we investigated the function and underlying mechanisms of miR-10b in human CC. Read More

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November 2018
1 Read

Expression of Metallothionein I/II and Ki-67 Antigen in Graves' Disease.

Anticancer Res 2018 Dec;38(12):6847-6853

Department of Histology and Embryology, Medical University of Wroclaw, Wroclaw, Poland.

Background/aim: The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid.

Patients And Methods: MT-I/II and Ki-67 antigen expression was studied using immunohistochemistry in 72 GD and 24 NG patients.

Results: MT-I/II expression was noted in the cytoplasm and nuclei of thyrocytes of GD and NG patients. Read More

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December 2018

Long-term effects of radioiodine treatment on salivary gland function in adult survivors of pediatric differentiated thyroid carcinoma.

J Nucl Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Endocrinology, University of Groningen, University Medical Center Groningen, Netherlands.

Pediatric differentiated thyroid cancer (DTC) is a rare disease. Initial treatment of DTC consists of a (near) total thyroidectomy and radioactive iodine (I) therapy. Previous studies in adults showed that I treatment may result in a reduced salivary gland function. Read More

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November 2018

Associations of serum perfluoroalkyl substance and vitamin D biomarker concentrations in NHANES, 2003-2010.

Int J Hyg Environ Health 2018 Nov 28. Epub 2018 Nov 28.

Department of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21215, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21215, USA. Electronic address:

Perfluoroalkyl substances (PFAS) are persistent endocrine disrupting chemicals found in industrial and commercial products. Previous research has shown that other endocrine disrupting chemicals such as phthalates and bisphenol A may alter circulating levels of vitamin D; however, no research has examined associations between PFAS and vitamin D biomarkers. We conducted a cross-sectional analysis of 7040 individuals aged 12 years and older participating in the 2003-2010 cycles of the United States National Health and Nutrition Examination Survey (NHANES). Read More

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November 2018
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