28,839 results match your criteria Endocrine Metabolic & Immune Disorders - Drug Targets[Journal]


Endothelial dysfunction in pregnancy metabolic disorders.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 19. Epub 2019 Feb 19.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, 8370146 Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, 8331150 Santiago, Chile. Electronic address:

In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.009DOI Listing
February 2019

Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis.

Diabetes Metab J 2019 Feb;43(1):31-45

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (including fibrosis) tends to be worsened by the presence of diabetes. NAFLD is considered an emerging risk factor for type 2 diabetes mellitus and a contributor to the development of chronic diabetes-related complications. Read More

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http://dx.doi.org/10.4093/dmj.2019.0011DOI Listing
February 2019

Physical Activity and Bone Health: What Is the Role of Immune System? A Narrative Review of the Third Way.

Front Endocrinol (Lausanne) 2019 7;10:60. Epub 2019 Feb 7.

Laboratory of Experimental Biochemistry & Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Bone tissue can be seen as a physiological hub of several stimuli of different origin (e.g., dietary, endocrine, nervous, immune, skeletal muscle traction, biomechanical load). Read More

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http://dx.doi.org/10.3389/fendo.2019.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374307PMC
February 2019

Endocrine-Mediated Mechanisms of Metabolic Disruption and New Approaches to Examine the Public Health Threat.

Front Endocrinol (Lausanne) 2019 7;10:39. Epub 2019 Feb 7.

Nicholas School of the Environment, Duke University, Durham, NC, United States.

Obesity and metabolic disorders are of great societal concern and generate substantial human health care costs globally. Interventions have resulted in only minimal impacts on disrupting this worsening health trend, increasing attention on putative environmental contributors. Exposure to numerous environmental contaminants have, over decades, been demonstrated to result in increased metabolic dysfunction and/or weight gain in cell and animal models, and in some cases, even in humans. Read More

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http://dx.doi.org/10.3389/fendo.2019.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374316PMC
February 2019

Cumulative effects of municipal effluent and parasite infection in yellow perch: A field study using high-throughput RNA-sequencing.

Sci Total Environ 2019 Feb 13;665:797-809. Epub 2019 Feb 13.

Aquatic Contaminants Research Division, Water Science and Technology Directorate, Environment and Climate Change Canada, 105 McGill St., Montreal, QC H2E 2E7, Canada.

Multiple metabolic, immune and reproductive effects have been reported in fish residing in effluent-impacted sites. Natural stressors such as parasites also have been shown to impact the responses of organisms to chronic exposure to municipal effluent in the St. Lawrence River (Quebec, Canada). Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.155DOI Listing
February 2019

Elevated 1-h post-load plasma glucose is associated with right ventricular morphofunctional parameters in hypertensive patients.

Endocrine 2019 Feb 21. Epub 2019 Feb 21.

Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy.

Purpose: Emerging data demonstrate that type 2 diabetes mellitus (T2DM) is associated with right ventricular (RV) dysfunction. A cutoff point of 155 mg/dL for the 1-hour (h) post-load plasma glucose, during oral glucose tolerance test (OGTT), identifies patients with normal glucose tolerance (NGT) at high risk to develop T2DM and cardiovascular (CV) disease. We investigated if 1-h post-load glucose may affect RV geometry and function in a group of never-treated hypertensive individuals. Read More

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http://dx.doi.org/10.1007/s12020-019-01873-5DOI Listing
February 2019

Obesity is associated with folate metabolism.

Int J Vitam Nutr Res 2019 Feb 21:1-12. Epub 2019 Feb 21.

1 Gazi University, Faculty of Health Sciences, Department of Nutrition and Dietetics, 06560 Beşevler, Ankara, Turkey.

Objective: The aim of the present study is to perform a systemic review of the previous studies executed on the association between obesity and folate.

Method: In the present research, the selected keywords were scanned on the PubMed, Web of Science, Cochrane and Lilac databases between May and June, 2017 through Gazi University's network. In total, 4236 clinical, randomized controlled, cross-sectional and prospective studies were determined and 17 of these that specifically fit the aims of the present research were reviewed. Read More

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http://dx.doi.org/10.1024/0300-9831/a000515DOI Listing
February 2019

Beneficial effects of a lifestyle intervention program on C-reactive protein: Impact of cardiorespiratory fitness in obese adolescents with sleep disturbances.

Am J Physiol Regul Integr Comp Physiol 2019 Feb 21. Epub 2019 Feb 21.

Sports Science Faculty, University of Bourgogne Franche-Comté.

Objectives: To assess the relationship between inflammation and OSA, and whether the lifestyle program's effects on inflammatory markers are associated with changes in anthropometric parameters, cardiorespiratory fitness, sleep duration and OSA severity in severely obese adolescents.

Study Design: Participants were aged 14.6 ± 1. Read More

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http://dx.doi.org/10.1152/ajpregu.00309.2018DOI Listing
February 2019

Spontaneous ketonuria and risk of incident diabetes: a 12 year prospective study.

Diabetologia 2019 Feb 20. Epub 2019 Feb 20.

Department of Preventive Medicine, Ajou University School of Medicine, 164 World cup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea.

Aims/hypothesis: Ketones may be regarded as a thrifty fuel for peripheral tissues, but their clinical prognostic significance remains unclear. We investigated the association between spontaneous fasting ketonuria and incident diabetes in conjunction with changes in metabolic variables in a large population-based observational study.

Methods: We analysed 8703 individuals free of diabetes at baseline enrolled in the Korean Genome and Epidemiology Study, a community-based 12 year prospective study. Read More

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http://dx.doi.org/10.1007/s00125-019-4829-xDOI Listing
February 2019

The Case for BPA as an Obesogen: Contributors to the Controversy.

Front Endocrinol (Lausanne) 2019 6;10:30. Epub 2019 Feb 6.

Department of Immunology, Tufts University School of Medicine, Boston, MA, United States.

Since the inception of the term endocrine disruptor, the idea that the environment is an important determinant of phenotype has motivated researchers to explore the effect of low dose exposure to BPA during organogenesis. The syndrome observed was complex, affecting various endpoints such as reproduction and reproductive tissues, behavior, mammary gland development and carcinogenesis, glucose homeostasis, and obesity. This constellation of impacted endpoints suggests the possibility of complex interactions among the multiple effects of early BPA exposure. Read More

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http://dx.doi.org/10.3389/fendo.2019.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372512PMC
February 2019

Clinical and biochemical characteristics of high-intensity functional training (HIFT) and overtraining syndrome: findings from the EROS study (The EROS-HIFT).

J Sports Sci 2019 Feb 20:1-12. Epub 2019 Feb 20.

a Adrenal and Hypertension Unit, Division of Endocrinology and Metabolism, Department of Medicine , Federal University of São Paulo Medical School , São Paulo , Brazil.

The metabolic and hormonal consequences of high-intensity functional training regimens such as CrossFit® (CF) are unclear. Little is known about the triggers and clinical and biochemical features of CF-related overtraining syndrome (OTS). The EROS study compared endocrine and metabolic responses, and eating, social, psychological and body characteristics of OTS-affected (OTS) and healthy athletes (ATL), and non-physically active controls (NPAC). Read More

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http://dx.doi.org/10.1080/02640414.2018.1555912DOI Listing
February 2019

Changes of vitamin D-binding protein, and total, bioavailable, and free 25-hydroxyvitamin D in transgender people.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Internal Medicine, Endocrine Section, and Center of Expertise on Gender Dysphoria, Amsterdam, the Netherlands.

Context: Total 25-hydroxyvitamin D [25(OH)D] is mainly bound to vitamin D-binding protein (DBP). Bioavailable 25(OH)D consists of albumin-bound and free 25(OH)D and is available for metabolic processes. As sex steroids influence DBP, hormonal treatment (HT) in transgender people might affect DBP and consequently the available 25(OH)D. Read More

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http://dx.doi.org/10.1210/jc.2018-02602DOI Listing
February 2019

Thyroid hormone profiles and TSH evaluation during early pregnancy and the transition period in dairy cows.

Theriogenology 2019 Jan 29;129:23-28. Epub 2019 Jan 29.

Clinic for Cattle, Endocrinology Laboratory, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173, Hanover, Germany. Electronic address:

The thyroid hormone axis is one important endocrine system within a complex system of various factors and hormones necessary to establish and maintain pregnancy in cattle and in metabolic adaptations towards lactation. Pregnancy and lactation occur contemporaneously in dairy cows, and have major impacts on thyroid hormones as well as status of the hypothalamus-pituitary thyroid axis influences pregnancy and lactation. As especially the thyroid hormone axis with special focus to TSH is not well studies in the past, the aim of the study was to examine the thyroid hormone axis, especially in heifers during adaptation to the first lactation, to verify the association between lactation and thyroid hormones. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.01.023DOI Listing
January 2019

Thyroid Hormones in Critical Illness.

Crit Care Clin 2019 Apr 24;35(2):375-388. Epub 2019 Jan 24.

Endocrine and Metabolic Unit, Royal Adelaide Hospital, Port Road, Adelaide, South Australia 5000, Australia.

Thyroid hormone is integral for normal function, yet during illness, circulating levels of the most active form (triiodothyronine [T3]) decline. Whether this is an adaptive response in critical illness or contributes to progressive disease has remained controversial. This review outlines the basis of thyroid hormone changes during critical illness and considers the evidence regarding T3 replacement. Read More

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http://dx.doi.org/10.1016/j.ccc.2018.11.012DOI Listing

Butyrate stimulates hepatic gluconeogenesis in mouse primary hepatocytes.

Exp Ther Med 2019 Mar 28;17(3):1677-1687. Epub 2018 Dec 28.

Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China.

Butyrate is a major short-chain fatty acid (SCFA) produced by microbial fermentation of dietary fiber in the gastrointestinal tract. Butyrate is also a well-known broad-spectrum histone deacetylase (HDAC) inhibitor. Butyrate has been reported to improve energy metabolism in rodents, which is associated with its beneficial effects on skeletal muscle, brown fat tissue and pancreatic β-cells. Read More

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http://dx.doi.org/10.3892/etm.2018.7136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364177PMC

Developmental exposure to a very low dose of bisphenol A induces persistent islet insulin hypersecretion in Fischer 344 rat offspring.

Environ Res 2019 Feb 8;172:127-136. Epub 2019 Feb 8.

Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden. Electronic address:

Background: In children with obesity, accentuated insulin secretion has been coupled with development of type 2 diabetes mellitus (T2DM). Bisphenol A (BPA) is a chemical with endocrine- and metabolism-disrupting properties which can be measured in a majority of the population. Exposure to BPA has been associated with the development of metabolic diseases including T2DM. Read More

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http://dx.doi.org/10.1016/j.envres.2019.02.009DOI Listing
February 2019

Recent advances in adrenal autoimmunity.

Expert Rev Endocrinol Metab 2009 Jul;4(4):333-348

e Department of Internal Medicine, Via E. Dal Pozzo, 06126 Perugia, Italy.

Autoimmune Addison's disease (AAD) results from the immune-mediated destruction of adrenocortical cells. AAD is a major component of the autoimmune polyendocrine syndromes type 1 (APS 1) and type 2. The adrenal autoimmune process is made evident by the apperance of circulating autoantibodies against the steroidogenic enzyme 21-hydroxylase. Read More

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http://dx.doi.org/10.1586/eem.09.20DOI Listing

Multiple endocrine neoplasia type 1.

Expert Rev Endocrinol Metab 2009 Jul;4(4):371-388

d Department of Metabolic and Endocrine Diseases, PO Box 85090, 3508 AB Utrecht.

Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal-dominant inherited tumor syndrome characterized by hyperplasia and/or tumors in the parathyroid glands, the pancreatic islets, the anterior pituitary and adrenal glands, as well as neuroendocrine tumors in the thymus, lungs and stomach, and tumors in nonendocrine tissues. In 1997, the responsible MEN1 gene was identified as a tumor-suppressor gene and its product was named menin. In this review, guidelines for early diagnosis, including MEN1 gene mutation analysis, and treatment, including periodic clinical monitoring, have been formulated, enabling improvement of life expectancy and quality of life. Read More

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http://dx.doi.org/10.1586/eem.09.22DOI Listing

A role for corticosteroid-binding globulin variants in stress-related disorders.

Expert Rev Endocrinol Metab 2012 May;7(3):301-308

b Endocrine & Metabolic Unit, The University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia.

Primary stress-related diseases such as chronic fatigue syndrome, fibromyalgia or chronic widespread pain have been associated with altered activity of the hypothalamic-pituitary-adrenal axis due to measured relative hyper- or hypo-cortisolism in basal or experimentally stimulated states. A hereditary risk to development of these diseases has been proposed. Corticosteroid-binding globulin (CBG), a plasma transport vehicle for cortisol, may play a more active role in the hypothalamic-pituitary-adrenal axis. Read More

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http://dx.doi.org/10.1586/eem.12.20DOI Listing
May 2012
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Is prolactin involved in the evolution of atherothrombotic disease?

Expert Rev Endocrinol Metab 2012 May;7(3):345-361

f INSERM, Unit 845, Faculty of Medicine, Research Center in Growth and Signaling, Team 'PRL/GH Pathophysiology', University Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine Necker, Paris, France.

Cardiovascular diseases (CVDs) account for approximately 30% of all deaths globally. The most important cause of CVD is atherothrombosis, in other words, narrowing of the arteries as a result of the deposition of cholesterol and other lipoid substances within the arterial wall. Several endocrine disorders have been linked to this pathological state. Read More

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http://dx.doi.org/10.1586/eem.12.23DOI Listing

Recent results of basic and clinical research in MEN1: opportunities to improve early detection and treatment.

Expert Rev Endocrinol Metab 2012 May;7(3):331-344

c Department of Metabolic Diseases, University Medical Center, Utrecht, The Netherlands.

Due to the variable expression of multiple endocrine neoplasia type 1 (MEN1), it is difficult to predict the course of the disease. However, knowledge about the normal function of the MEN1 gene product, together with the effects of cellular derangement by subsequent genetic events, has increased considerably. At first, the possible existence of a genotype-phenotype correlation is discussed. Read More

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http://dx.doi.org/10.1586/eem.12.22DOI Listing

Divergent Changes in Plasma AGEs and sRAGE Isoforms Following an Overnight Fast in T1DM.

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

School of Kinesiology, University of Michigan, 401 Washtenaw Ave., Ann Arbor, MI 48109, USA.

Advanced glycation end products (AGEs) promote the development of diabetic complications through activation of their receptor (RAGE). Isoforms of soluble RAGE (sRAGE) sequester AGEs and protect against RAGE-mediated diabetic complications. We investigated the effect of an overnight fast on circulating metabolic substrates, hormones, AGEs, and sRAGE isoforms in 26 individuals with type 1 diabetes (T1DM). Read More

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http://dx.doi.org/10.3390/nu11020386DOI Listing
February 2019

A decision algorithm to identify patients with high probability of monogenic diabetes due to HNF1A mutations.

Endocrine 2019 Feb 18. Epub 2019 Feb 18.

Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland.

Purpose: To investigate the utility of biomarkers of maturity-onset diabetes of the young (MODY), high-sensitivity C-reactive protein (hsCRP), and 1,5-anhydroglucitol (1,5-AG) in conjunction with other clinical and laboratory features to improve diagnostic accuracy and provide a diagnostic algorithm for HNF1A MODY.

Methods: We examined 77 patients with HNF1A MODY, 88 with GCK MODY mutations, 99 with type 1 diabetes, and 92 with type 2 diabetes. In addition to 1,5-AG and hsCRP, we considered body mass index (BMI), fasting glucose, and fasting serum C-peptide as potential biomarkers. Read More

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http://dx.doi.org/10.1007/s12020-019-01863-7DOI Listing
February 2019

Interventions to Address Environmental Metabolism-Disrupting Chemicals: Changing the Narrative to Empower Action to Restore Metabolic Health.

Front Endocrinol (Lausanne) 2019 4;10:33. Epub 2019 Feb 4.

Department of Pediatrics, University of Michigan, Ann Arbor, MI, United States.

Metabolic disease rates have increased dramatically over the last four decades. Classic understanding of metabolic physiology has attributed these global trends to decreased physical activity and caloric excess; however, these traditional risk factors insufficiently explain the magnitude and rapidity of metabolic health deterioration. Recently, the novel contribution of environmental metabolism-disrupting chemicals (MDCs) to various metabolic diseases (including obesity, diabetes, and non-alcoholic fatty liver disease) is becoming recognized. Read More

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http://dx.doi.org/10.3389/fendo.2019.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369180PMC
February 2019

Long-Term Effectiveness of a Lifestyle Intervention: A Pragmatic Community Trial to Prevent Metabolic Syndrome.

Am J Prev Med 2019 Mar;56(3):437-446

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction: The purpose of this study is to evaluate the long-term effectiveness of a community-based lifestyle education on primary prevention of metabolic syndrome in a middle-income country.

Study Design: This study followed 3,180 individuals free of metabolic syndrome who were under the coverage of three health centers in Tehran from 1999 until 2015. They were undergoing triennial examinations resulting in four re-exams. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.10.029DOI Listing

Gestational Diabetes Mellitus is Associated with Plasma Amylase in a Chinese Pregnant Women Population.

Clin Lab 2019 Jan;65(1)

Background: The study aimed to investigate the relationship between plasma amylase levels and the endocrine and metabolic biomarkers in Chinese pregnant women with gestational diabetes mellitus (GDM) in the southwest of China and to compare plasma amylase with other known biomarkers in relation to their contributions to identifying GDM, with a view to establishing plasma amylase as an independent laboratory-based risk factor for GDM.

Methods: This study included 1,870 pregnant women divided into three groups: early pregnancy, middle pregnancy, and late pregnancy according to weeks of gestation, and 164 pregnant women were excluded by diseases. Fasting samples of participants were collected and plasma amylase and other metabolic markers were measured. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180550DOI Listing
January 2019

Overcoming Challenges of Implementing Chronic Care Model in Diabetes Management: An Action Research Approach.

Int J Prev Med 2019 15;10:13. Epub 2019 Jan 15.

Diabetologist of Diabetes Unit, Shahid Malakooti Polyclinic of Social Welfare Organization of Isfahan, Diabetes Clinic, IR, Iran.

Background: Reforming the health care system to improve suitable health care model for diabetic patients is essential. This study aimed to implement, identify, and overcome the challenges of implementing the Chronic Care Model in diabetes management in a clinic.

Methods: This study is a qualitative technical action research with the Kemmis and McTaggart model including planning, action, reflection, observation, and revision plan which was conducted in the specialized polyclinic from 2015 to 2017 in Isfahan city - Iran. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_485_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360841PMC
January 2019
4 Reads

Clinical Trial of the Effects of Coenzyme Q10 Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Hemodialysis Patients.

Int J Prev Med 2019 15;10:12. Epub 2019 Jan 15.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Background: The aim of the study was to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among diabetic hemodialysis (HD) patients.

Methods: Sixty diabetic HD patients participated in the randomized, double blind, placebo-controlled clinical trial. They were randomly assigned into two groups to intake either 60 mg CoQ10 supplements ( = 30) or placebo ( = 30) twice a day for 12 weeks. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_418_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360842PMC
January 2019

ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians' Perspective.

Front Endocrinol (Lausanne) 2019 1;10:27. Epub 2019 Feb 1.

Division Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands.

Human aging is currently defined as a physiological decline of biological functions in the body with a continual adaptation to internal and external damaging. The endocrine system plays a major role in orchestrating cellular interactions, metabolism, growth, and aging. Several studies from worms to mice showed that downregulated activity of the GH/IGF-1/insulin pathway could be beneficial for the extension of human life span, whereas results are contradictory in humans. Read More

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http://dx.doi.org/10.3389/fendo.2019.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367275PMC
February 2019

H NMR-based metabolomic analysis of nine organophosphate flame retardants metabolic disturbance in Hep G2 cell line.

Sci Total Environ 2019 Feb 4;665:162-170. Epub 2019 Feb 4.

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, China. Electronic address:

Organophosphate flame retardants (OPFRs) are frequently found in the environment and could be adversely affecting organisms. In fact, nine OPFRs have been shown to cause endocrine disruptions, but information on the metabolism-perturbing properties of these OPFRs remains unclear. In this study, the H-nuclear magnetic resonance (NMR) based metabolomic method was applied to evaluate the metabolic disturbances caused by these nine OPFRs. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.055DOI Listing
February 2019

Effect of long-term sodium nitrate administration on diabetes-induced anemia and glucose homeostasis in obese type 2 diabetic male rats.

Nitric Oxide 2019 Feb 14. Epub 2019 Feb 14.

Endocrine Physiology Research Center, Research Institute for Endocrine Sciences. Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Purpose: Anemia is common in patients with type 2 diabetes. This aims at determining long-term effects of nitrate administration on diabetes-induced anemia in obese type 2 diabetic rats.

Methods: Male Wistar rats were divided into 4 groups: Control, control + nitrate, diabetes, and diabetes + nitrate. Read More

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http://dx.doi.org/10.1016/j.niox.2019.02.003DOI Listing
February 2019

Parental exposure to tris(1,3-dichloro-2-propyl) phosphate results in thyroid endocrine disruption and inhibition of growth in zebrafish offspring.

Aquat Toxicol 2019 Feb 7;209:132-141. Epub 2019 Feb 7.

Key Laboratory of Preparation and Application of Environmental Friendly Materials, the Ministry of Education, Jilin Normal University, Siping, 136000, China.

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a re-emerging environmental contaminant used as a suitable substitute for brominated flame retardants. The objective of this study was to evaluate the effects of TDCIPP on thyroid disruption and growth inhibition in zebrafish (Danio rerio) offspring after chronic parental exposure, and to examine the possible molecular mechanisms involved. When adult zebrafish (4 months old) were exposed to 5. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.02.004DOI Listing
February 2019
2 Reads

Impact of the CYP2D6 phenotype on hyperprolactinemia development as an adverse event of treatment with atypical antipsychotic agents in pediatric patients.

Ir J Med Sci 2019 Feb 15. Epub 2019 Feb 15.

Discipline of Medical Genetics, Department of Microscopic Morphology, Victor Babeş University of Medicine and Pharmacy Timișoara, Timișoara, Romania.

Background: Treatment with atypical antipsychotics is today the election therapy for different types of psychosis, but there is a high incidence of endocrine and metabolic disturbances. One of the major enzymes involved in the metabolism of antipsychotics is CYP2D6. Depending on the existing CYP2D6 alleles, the metabolic capacity of the enzyme may vary from very low to very high, so that patients can be grouped into four phenotypic groups: slow, intermediate, extensive (normal), and fast metabolizers. Read More

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http://dx.doi.org/10.1007/s11845-019-01985-xDOI Listing
February 2019
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The Diabetes Unmet Need with basal insulin Evaluation (DUNE) study in type 2 diabetes: Achieving HbA targets with basal insulin in a real-world setting.

Diabetes Obes Metab 2019 Feb 15. Epub 2019 Feb 15.

Diabetes Research Centre, University of Leicester, Leicester, UK.

Aims: To describe in a real-world setting the achievement of physician-selected individualized HbA targets in people with type 2 diabetes, newly or recently initiated on basal insulin, and the association of hypoglycemia with target achievement.

Materials And Methods: A 12-week, prospective, single-arm, observational study of adults with type 2 diabetes either newly initiated with any basal insulin or started on basal insulin within the preceding 12 months. At enrollment, eligible participants from 28 countries were treated with or without oral antihyperglycemic drugs and/or GLP-1 receptor agonists. Read More

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http://doi.wiley.com/10.1111/dom.13673
Publisher Site
http://dx.doi.org/10.1111/dom.13673DOI Listing
February 2019
5 Reads

The Role of Ketone Signaling in the Hepatic Response to Fasting.

Am J Physiol Gastrointest Liver Physiol 2019 Feb 15. Epub 2019 Feb 15.

School of Animal and Comparative Biomedical Scieces, U. Arizona, United States.

Ketosis is a metabolic adaptation to fasting, non-alcoholic fatty liver disease (NAFLD), and prolonged exercise. β-OH butyrate acts as a transcriptional regulator and at G-protein coupled receptors to modulate cellular signaling pathways in a hormone-like manner. While physiological ketosis is often adaptive, chronic hyperketonemia may contribute to the metabolic dysfunction of NAFLD. Read More

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http://dx.doi.org/10.1152/ajpgi.00415.2017DOI Listing
February 2019
1 Read

Hyperandrogenic origins of polycystic ovary syndrome - implications for pathophysiology and therapy.

Expert Rev Endocrinol Metab 2019 Jan 31:1-13. Epub 2019 Jan 31.

a Department of Obstetrics and Gynecology , University of Wisconsin , Madison , WI , USA.

Introduction: Polycystic ovary syndrome (PCOS) diagnosis comprises combinations of female hyperandrogenism, menstrual irregularity and polycystic ovaries. While it is a familial and highly prevalent endocrine disorder, progress towards a cure is hindered by absence of a definitive pathogenic mechanism and lack of an animal model of naturally occurring PCOS. Areas covered: These include an overview of PCOS and its potential etiology, and an examination of insights gained into its pathogenic origins. Read More

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http://dx.doi.org/10.1080/17446651.2019.1576522DOI Listing
January 2019
1 Read

Psychobiological factors of resilience and depression in late life.

Transl Psychiatry 2019 Feb 14;9(1):88. Epub 2019 Feb 14.

Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA.

In contrast to traditional perspectives of resilience as a stable, trait-like characteristic, resilience is now recognized as a multidimentional, dynamic capacity influenced by life-long interactions between internal and environmental resources. We review psychosocial and neurobiological factors associated with resilience to late-life depression (LLD). Recent research has identified both psychosocial characteristics associated with elevated LLD risk (e. Read More

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http://www.nature.com/articles/s41398-019-0424-7
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http://dx.doi.org/10.1038/s41398-019-0424-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375932PMC
February 2019
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Comparative Effects of Proximal and Distal Small Intestinal Glucose Exposure on Glycemia, Incretin Hormone Secretion, and the Incretin Effect in Health and Type 2 Diabetes.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia

Objective: Cells releasing glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are distributed predominately in the proximal and distal gut, respectively. Hence, the region of gut exposed to nutrients may influence GIP and GLP-1 secretion and impact on the incretin effect and gastrointestinal-mediated glucose disposal (GIGD). We evaluated glycemic and incretin responses to glucose administered into the proximal or distal small intestine and quantified the corresponding incretin effect and GIGD in health and type 2 diabetes mellitus (T2DM). Read More

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http://dx.doi.org/10.2337/dc18-2156DOI Listing
February 2019

Association between duration of endogenous estrogen exposure and cardiovascular outcomes: A population - based cohort study.

Life Sci 2019 Feb 11. Epub 2019 Feb 11.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aims: Duration of endogenous estrogen exposure is apparently associated with risk of cardiovascular disease, the longer durations being more cardiovascular disease protective in women. We aimed to investigate the association of cumulative duration of endogenous estrogen exposure over women's reproductive lifespans with cardiovascular disease outcomes.

Main Methods: For the purpose of the present study, of 10,192 female participants, after excluding those using HRT (n = 84), 3656 women, aged ≥30 years, who met eligibility criteria were selected and divided into three groups based on tertiles (T1, T2, T3) of exposure durations to endogenous estrogen. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.020DOI Listing
February 2019

DYSGLYCEMIA-BASED CHRONIC DISEASE: AN AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS POSITION STATEMENT.

Endocr Pract 2018 Nov;24(11):995-1011

The American Association of Clinical Endocrinologists (AACE) has created a dysglycemia-based chronic disease (DBCD) multimorbidity care model consisting of four distinct stages along the insulin resistance-prediabetes-type 2 diabetes (T2D) spectrum that are actionable in a preventive care paradigm to reduce the potential impact of T2D, cardiometabolic risk, and cardiovascular events. The controversy of whether there is value, cost-effectiveness, or clinical benefit of diagnosing and/or managing the prediabetes state is resolved by regarding the problem, not in isolation, but as an intermediate stage in the continuum of a progressive chronic disease with opportunities for multiple concurrent prevention strategies. In this context, stage 1 represents "insulin resistance," stage 2 "prediabetes," stage 3 "type 2 diabetes," and stage 4 "vascular complications. Read More

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http://dx.doi.org/10.4158/PS-2018-0139DOI Listing
November 2018
1 Read

Depressive symptoms in inflammatory bowel disease: an extraintestinal manifestation of inflammation?

Clin Exp Immunol 2019 Feb 14. Epub 2019 Feb 14.

Centre for Inflammation Biology and Cancer Immunology, King's College London.

Depressive symptoms are reported by more than 20% of people with inflammatory bowel disease (IBD), whilst sleep difficulties and fatigue are even more common. Comorbid depressive symptoms predict a poor IBD course, including increased risk of relapse and surgery, which is inconsistently improved by psychological treatments. Rather than being distinct systems, there is compelling evidence for bidirectional communication between gut and brain, driven by neural, metabolic, endocrine and inflammatory mediators. Read More

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http://dx.doi.org/10.1111/cei.13276DOI Listing
February 2019
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The Importance of Peripheral Nerves in Adipose Tissue for the Regulation of Energy Balance.

Biology (Basel) 2019 Feb 12;8(1). Epub 2019 Feb 12.

Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME 04469, USA.

Brown and white adipose tissues are essential for maintenance of proper energy balance and metabolic health. In order to function efficiently, these tissues require both endocrine and neural communication with the brain. Brown adipose tissue (BAT), as well as the inducible brown adipocytes that appear in white adipose tissue (WAT) after simulation, are thermogenic and energy expending. Read More

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http://dx.doi.org/10.3390/biology8010010DOI Listing
February 2019

Correction to: Completion Thyroidectomy: Revisited a Quarter of a Century Later.

Ann Surg Oncol 2019 Feb 12. Epub 2019 Feb 12.

Department of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, USA.

In the original article's XML file, Benzon M. Dy's middle initial was tagged incorrectly. The error has been addressed with this correction. Read More

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http://dx.doi.org/10.1245/s10434-019-07234-wDOI Listing
February 2019

Estimation of Serum Zinc, Copper and Magnesium Levels in Bangladeshi women with Gestational Diabetes Mellitus Attending in a Tertiary Care Hospital.

Mymensingh Med J 2019 Jan;28(1):157-162

Dr Farzana Akonjee Mishu, Assistant Professor of Biochemistry, Department of Physiology and Molecular Biology, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine & Metabolic Disorders (BIRDEM), Dhaka, Bangladesh; E-mail:

Zinc (Zn), Copper (Cu) and Magnesium (Mg) are essential trace elements for normal embryogenesis and fetal growth. Alteration of Zn, Cu and Mg concentrations in blood has been observed in normal pregnancy as well as in gestational diabetes mellitus (GDM). Aim of this study was to evaluate the serum Zn, Cu and Mg levels in Bangladeshi women with GDM in their second and third trimester of pregnancy. Read More

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January 2019
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Frequency and Predictors of Erectile Dysfunction in Bangladeshi Men with Type 2 Diabetes Mellitus: Experience from a Tertiary Center.

Mymensingh Med J 2019 Jan;28(1):137-143

Dr Mohammad Imtiaj Mahbub, Assistant Professor, Department of Endocrinology, Rajshahi Medical College & Hospital, Rajshahi, Bangladesh; E-mail:

Erectile dysfunction (ED) is a common complication of diabetes mellitus. But it is frequently under diagnosed and may result in poor quality of life. Previous studies have shown a high frequency of ED in diabetic men. Read More

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January 2019

Diagnostic Accuracy of Refractory Shadowing from Uterine Leiomyomas: Sonographic-Pathologic Correlation.

Mymensingh Med J 2019 Jan;28(1):120-125

Dr Tapashi Rahman Khan, Assistant Professor, Department Radiology and Imaging, Dhaka Community Medical College & Hospital, Mogbazar, Dhaka, Bangladesh; E-mail:

This cross sectional study was carried out in the Department of Radiology & Imaging, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh from July 2010 to June 2011 with a view to evaluate the diagnostic accuracy of refractory shadowing on transabdominal pelvic sonography for leiomyomas and in differentiating them from other pelvic masses. Histopathological examination of the surgically resected masses was taken as the standard diagnostic tool. A total number of 50 patients of pelvic masses were studied. Read More

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January 2019

Relationship between HbA1c and Lipid Profile Seen in Bangladeshi Type 2 Diabetes Mellitus Patients Attending BIRDEM Hospital: A Cross-Sectional Study.

Mymensingh Med J 2019 Jan;28(1):91-95

Dr Afsana Begum, Lecturer, Department of Biochemistry, Mugda Medical College (MuMC), Dhaka, Bangladesh; E-mail:

Diabetes mellitus is one of the leading non-communicable diseases all over the world including Bangladesh. Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. Glycated hemoglobin (HbA1c) level of ≥6. Read More

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January 2019

Pattern of Anaemia in Chronic Kidney Disease.

Mymensingh Med J 2019 Jan;28(1):1-7

Dr Mohammad Omar Faruque Miah, Senior Clinical Pathologist, Mymensingh Medical College Hospital, Mymensingh, Bangladesh.

The prevalence of chronic kidney disease (CKD) in Bangladesh is increasing. Chronic kidney disease refers to an irreversible deterioration in renal function which classically develops over a period of years. Initially, it manifest's only as a biochemical abnormality. Read More

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January 2019
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Insulin and Insulin Receptors in Adipose Tissue Development.

Int J Mol Sci 2019 Feb 11;20(3). Epub 2019 Feb 11.

Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, 70124 Bari, Italy.

Insulin is a major endocrine hormone also involved in the regulation of energy and lipid metabolism via the activation of an intracellular signaling cascade involving the insulin receptor (INSR), insulin receptor substrate (IRS) proteins, phosphoinositol 3-kinase (PI3K) and protein kinase B (AKT). Specifically, insulin regulates several aspects of the development and function of adipose tissue and stimulates the differentiation program of adipose cells. Insulin can activate its responses in adipose tissue through two INSR splicing variants: INSR-A, which is predominantly expressed in mesenchymal and less-differentiated cells and mainly linked to cell proliferation, and INSR-B, which is more expressed in terminally differentiated cells and coupled to metabolic effects. Read More

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http://dx.doi.org/10.3390/ijms20030759DOI Listing
February 2019

Changes in expression of microRNA potentially targeting key regulators of lipid metabolism in primary gilthead sea bream hepatocytes exposed to phthalates or flame retardants.

Aquat Toxicol 2019 Feb 4;209:81-90. Epub 2019 Feb 4.

School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III Da Varano, I-62032 Camerino (MC), Italy. Electronic address:

Metabolism disrupting chemicals (MDCs) belong to the group of endocrine-disrupting chemicals (EDCs) and are known to affect endocrine and metabolic functions of liver. There is growing evidence that MDCs may also act modulating the expression levels of micro ribonucleic acids (miRNAs) and thus affecting post-transcriptional expression of hundreds of target genes. Herein, we used a gilthead sea bream in vitro hepatocyte model for analyzing the effects of an exposure to phthalates (i. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.02.002DOI Listing
February 2019