3,351 results match your criteria Endocrine Journal [Journal]


A case of functioning gonadotroph adenoma in a reproductive aged woman.

Endocr J 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, The University of Tokyo Hospital, Tokyo 1138655, Japan.

A 34-year-old woman presented our hospital with complaint of irregular menstruation and abnormal uterine bleeding lasting for a month. After her second parturition at the age of 27, her menstrual cycle had been regular, but it suddenly became irregular at the age of 30. Transvaginal ultrasound revealed the presence of ovarian mass, and the patient underwent diagnostic laparoscopic surgery. Read More

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http://dx.doi.org/10.1507/endocrj.EJ19-0066DOI Listing

Tumor doubling time predicts response to sorafenib in radioactive iodine-refractory differentiated thyroid cancer.

Endocr J 2019 Apr 19. Epub 2019 Apr 19.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

Sorafenib has emerged as an effective therapeutic option for radioactive iodine (RAI)-refractory, locally advanced or metastatic differentiated thyroid cancer (DTC). We investigated the efficacy and safety of sorafenib treatment in a real-world setting and unveil predictive markers of responsiveness to sorafenib. The treatment response, progression-free survival (PFS), overall survival, and adverse events (AEs) of sorafenib-treated RAI-refractory, locally advanced or metastatic DTC patients at three institutes were retrospectively reviewed, and their tumor doubling time was calculated by three investigators. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0488DOI Listing

Long non-coding RNA H19 is associated with polycystic ovary syndrome in Chinese women: a preliminary study.

Endocr J 2019 Apr 13. Epub 2019 Apr 13.

Department of Obstetrics and Gynecology, the First Clinical Medical College of Jinan University, Guangzhou, Guangdong 510632, China.

Polycystic ovary syndrome (PCOS) represents a serious reproductive and endocrine condition and is associated with high incidence rates. H19 is a compelling long noncoding RNA (lncRNA) which carries out a range of biological functions. However, prior to this study, little was known as to whether there was an association between lncRNA H19 and PCOS. Read More

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http://dx.doi.org/10.1507/endocrj.EJ19-0004DOI Listing
April 2019
1 Read

The clinical course and potential underlying mechanisms of everolimus-induced hyperglycemia.

Endocr J 2019 Apr 13. Epub 2019 Apr 13.

Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Ishikawa 920-8640, Japan.

The mechanistic target of rapamycin (mTOR) inhibitor everolimus is an antitumor agent known to cause hyperglycemia. However, the clinical course of everolimus-induced hyperglycemia, its pathophysiological basis, and the treatment strategy are not clear. In this case series report, we present the clinical course of everolimus-induced hyperglycemia in four patients. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0542DOI Listing
April 2019
1 Read

MiR-181c affects estrogen-dependent endometrial carcinoma cell growth by targeting PTEN.

Endocr J 2019 Apr 11. Epub 2019 Apr 11.

Department of Center for Reproductive Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, China.

MicroRNAs (miRNAs), which is a type of non-coding and single-stranded small molecule RNA, bind either completely or incompletely to 3'-UTR of the target gene mRNA to inhibit mRNA translation or degradation. In our study, we aimed to explore the roles and mechanisms of miR-181c in the apoptosis of RL95-2 human endometrial carcinoma cells. Cell activity and apoptosis were detected by cell counting Kit-8 (CCK-8) assay and flow cytometry (FCM), respectively. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0538DOI Listing
April 2019
1 Read

Drug-induced hyperglycemia in the Japanese Adverse Drug Event Report database: association of evelolimus use with diabetes.

Endocr J 2019 Apr 2. Epub 2019 Apr 2.

Department of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Some categories of drugs are known for causing hyperglycemia or diabetes such as steroids, antipsychotics, and immunosuppressant. However, there has been little evidence from studies about the proportion of each drug in the context of drug-induced diabetes. In this study, we used data from the Japanese Adverse Drug Event Report (JADER) database, a spontaneous reporting system database maintained at the Pharmaceuticals and Medical Devices Agency (PMDA) of Japan, reported between April 2004 and June 2017. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0553DOI Listing
April 2019
8 Reads

Comparison of therapeutic effects of acarbose and metformin under different β-cell function status in Chinese patients with type 2 diabetes.

Endocr J 2019 Apr 2. Epub 2019 Apr 2.

Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, P. R. of China.

MARCH study suggested that acarbose had similar therapeutic effect on glycated hemoglobin reduction compared to metformin in newly diagnosed type 2 diabetes patients as initial therapy in China. We aimed to investigate whether the efficacy of acarbose was still similar to metformin under different β-cell function status. According to the homeostasis model assessment (HOMA)-β level, 670 patients were divided into better β-cell function group, medium β-cell function group and poor β-cell function group. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0466DOI Listing
April 2019
1 Read

Falsely elevated plasma ACTH levels measured by the Elecsys assay related to heterophilic antibody in a case of secondary adrenocortical insufficiency.

Endocr J 2019 Apr 3. Epub 2019 Apr 3.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8606, Japan.

A 49-year-old woman with membranous nephropathy was referred to our hospital during the tapering of oral prednisolone, because of suspicion of primary adrenal insufficiency based on a plasma ACTH level of 399.1 pg/mL in the Elecsys assay and a serum cortisol level of 3.1 μg/dL. Read More

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http://dx.doi.org/10.1507/endocrj.EJ19-0023DOI Listing
April 2019
2 Reads

Partial androgen insensitivity syndrome in a 68-year-old patient.

Endocr J 2019 Mar 28. Epub 2019 Mar 28.

Konya Training and Research Hospital, Endocrinology, Konya, Turkey.

Partial androgen insensitivity syndrome (PAIS) is a form of disorders of sexual development. Besides the issues of gender assignment, the fate of gonads in these patients poses a challenging problem. Debate still remains on the need and/or timing of gonadectomy in either complete or partial androgen insensitivity syndromes. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0578DOI Listing

Molecular analysis and literature-based hypothesis of an immunonegative prostate small cell carcinoma causing ectopic ACTH syndrome.

Endocr J 2019 Mar 28. Epub 2019 Mar 28.

Department of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan.

Ectopic ACTH syndrome (EAS) due to a prostate small cell carcinoma (SCC) is very rare with only 26 cases reported to date and has a poor prognosis. We here describe another case of this disorder that was clinically typical based on prior reports as it showed hypercortisolemia and severe hypokalemia with multiple metastasis. However, our current case of prostate SCC causing EAS is the first to display negative immunostaining for ACTH despite detectable POMC mRNA expression in the primary lesion. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0563DOI Listing

The long-term follow-up of patients with thionamide-treated Graves' hyperthyroidism.

Endocr J 2019 Mar 28. Epub 2019 Mar 28.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Since there have been few reports on the long-term prognosis of Graves' hyperthyroidism, the prognosis of 549 Graves' hyperthyroidism patients initially treated with thionamide and followed for >8 (range: 8.6-36.4) years was studied, evaluating the change in the TSH binding inhibitor immunoglobulin activity (TBII). Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0418DOI Listing
March 2019
1 Read

Circulating zinc-α2-glycoprotein is reduced in women with polycystic ovary syndrome, but can be increased by exenatide or metformin treatment.

Endocr J 2019 Mar 26. Epub 2019 Mar 26.

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.

The study was to investigate circulating zinc-α2-glycoprotein (ZAG) concentrations in women with PCOS, and changes in ZAG levels after exenatide or metformin treatment. One hundred eighty-two women with polycystic ovary syndrome (PCOS) who met the 2003 Rotterdam diagnostic criteria and 150 controls without PCOS were recruited. We partitioned women with PCOS into groups according to body mass index or blood glucose concentrations, determined serum ZAG, anthropometric parameters, metabolic and endocrine indicators, and inflammatory markers, and statistically analyzed the results. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0153DOI Listing
March 2019
2 Reads

Urinary iodine is increased in papillary thyroid carcinoma but is not altered by regional population iodine intake status: a meta-analysis and implications.

Endocr J 2019 Mar 19. Epub 2019 Mar 19.

Department of Radiology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.

Excessive iodine intake has been associated with increased risk of thyroid cancer (TC) in many studies, but the results have not been consistent. Since it was common knowledge that urinary iodine (UI) is considered a sensitive marker of current iodine intake, we conducted a meta-analysis to clarify the association between high UI and TC. We adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, and the Cochrane Collaboration. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0532DOI Listing
March 2019
1 Read

Reducing the gender gap in academic activities: a 10-year progress report by the Japan Endocrine Society Women Endocrinologists Association (JES-We-Can).

Endocr J 2019 Mar 15. Epub 2019 Mar 15.

Health Services Center, National Graduate Institute for Policy Studies, Tokyo 106-8677, Japan.

The Japan Endocrine Society (JES) has the largest ratio of female membership among societies associated with Internal Medicine in Japan; half of female members are in their 20s or 30s at present. In 2009, JES organized the "JES-We-Can" committee to promote women's career development. To evaluate the effectiveness of JES-We-Can, we investigated the gender balance of various activities at JES in fiscal 2009 and 2017. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0501DOI Listing

Lapatinib decreases the ACTH production and proliferation of corticotroph tumor cells.

Endocr J 2019 Mar 15. Epub 2019 Mar 15.

Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan.

Cushing's disease is almost always caused by hypersecretion of adrenocorticotropic hormone (ACTH) from a pituitary adenoma. A mutation in the deubiquitinase gene USP8 has been found in human ACTH-producing pituitary adenoma cells. This mutational hotspot hyperactivates USP8, rescuing epidermal growth factor receptor (EGFR) from lysosomal degradation and ensuring its sustained signaling in Cushing's disease. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0491DOI Listing
March 2019
1 Read

Important cytological findings for distinction between follicular variant and conventional papillary thyroid carcinoma, including noninvasive follicular thyroid tumors with papillary-like nuclear features.

Endocr J 2019 Mar 14. Epub 2019 Mar 14.

Department of Surgery, Kuma Hospital, Kobe 856-8562, Japan.

We studied cytological specimens of conventional papillary thyroid carcinoma (PTC), follicular variant papillary thyroid carcinoma (FVPTC), and noninvasive follicular thyroid tumor with papillary-like nuclear features (NIFTP) (formerly noninvasive FVPTC) to identify useful cytological parameters for their differentiation. Cytological findings of invasive FVPTC and NIFTP were very similar to each other but differed from those of conventional PTC. Intranuclear cytoplasmic inclusions, true papillary cell clusters, monolayered cell sheets, ropy colloids, multinucleate giant cells, psammoma bodies, and cystic background were the observed characteristic features of conventional PTC. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0525DOI Listing
March 2019
1 Read

Successful treatment of myxedema coma with a combination of levothyroxine and liothyronine.

Endocr J 2019 Mar 8. Epub 2019 Mar 8.

Division of Endocrinology, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya 453-8511, Japan.

Myxedema coma is a rare endocrine emergency resulting from the decompensation of severe hypothyroidism, which is associated with a high mortality rate. It is characterized by the deterioration of mental status, hypothermia, hypotension, hyponatremia, and hypoventilation. Early disease diagnosis and advancements in intensive supportive care have reduced the mortality rate. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0469DOI Listing
March 2019
3 Reads

The roles and role-players in thyroid cancer angiogenesis.

Endocr J 2019 Mar 6. Epub 2019 Mar 6.

Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Thyroid cancer is the most prevalent endocrine cancer worldwide. Angiogenesis, the formation of new blood vessels, plays a pivotal role in the development and progression of tumors. Over the past years, cancer research has focused on the ability of tumors to induce newly formed blood vessel, because tumor growth and the process of cancer metastasis mainly depends on angiogenesis. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0537DOI Listing
March 2019
2 Reads
2.019 Impact Factor

Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide.

Endocr J 2019 Mar 6. Epub 2019 Mar 6.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.

Pancreatic polypeptide (PP) is a 36-amino acid peptide encoded by the Ppy gene, which is produced by a small population of cells located in the periphery of the islets of Langerhans. Owing to the high amino acid sequence similarity among neuropeptide Y family members, antibodies against PP that are currently available are not convincingly specific to PP. Here we report the development of mouse monoclonal antibodies that specifically bind to PP. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0441DOI Listing

Association between serum thyrotropin within the euthyroid range and obesity.

Endocr J 2019 Mar 5. Epub 2019 Mar 5.

Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Centre, Beijing 100044, China.

The relationship between variations in thyroid function and indices of obesity remains a focus of debate. To explore the associations between thyroid function within the normal range and obesity and to evaluate potential modifying factors, we analyzed a large and well-characterized community cohort in Beijing, China, containing 1,816 men and 1,774 women with serum thyrotropin (TSH) levels within the reference range (0.55-4. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0140DOI Listing
March 2019
15 Reads

Serum autotaxin levels are associated with Graves' disease.

Endocr J 2019 Feb 27. Epub 2019 Feb 27.

Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.

Graves' Disease is a representative autoimmune thyroid disease that presents with hyperthyroidism. Emerging evidence has shown the involvement of lysophosphatidic acid (LPA) and its producing enzyme, autotaxin (ATX), in the pathogenesis of various diseases; among them, the involvement of the ATX/LPA axis in some immunological disturbances has been proposed. In this study, we investigated the association between serum ATX levels and Graves' disease. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0451DOI Listing
February 2019
1 Read

Inhibitory effects of methimazole and propylthiouracil on iodotyrosine deiodinase 1 in thyrocytes.

Endocr J 2019 Feb 27. Epub 2019 Feb 27.

Department of Clinical Laboratory Science, Faculty of Medical Technology, Teikyo University, Itabashi, Tokyo 173-8605, Japan.

Methimazole (MMI) and propylthiouracil (PTU) are commonly used for the treatment of Graves' disease. They share similar inhibitory effects on thyroid hormone biosynthesis by interfering with thyroid peroxidase (TPO)-mediated oxidation and organification of iodine. However, their potential effects on other thyroid functional molecules have not been explored in depth. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0380DOI Listing
February 2019
1 Read

Fulminant type 1 diabetes associated with Isolated ACTH deficiency induced by anti-programmed cell death 1 antibody-insight into the pathogenesis of autoimmune endocrinopathy.

Endocr J 2019 Feb 27. Epub 2019 Feb 27.

Division of Diabetes and Metabolism, Toho University Ohashi Medical Center, Tokyo 153-8515, Japan.

Therapeutic blocking antibodies against programmed death 1 (PD1) and cytotoxic T-lymphocyte antigen 4 (CTLA4) are applied for advanced cancer therapy, but induce a wide range of immune-related adverse events. In our recent case of a 52-year-old female doctor suffering from breast cancer having metastasized to the lung and liver, it was decided to use nivolumab to prevent the disease progressing after excisional surgeries and multiple chemotherapies. One month after completing the nivolumab course, fatigue, hypoglycemia and hypotension developed and isolated ACTH deficiency (IAD) was diagnosed. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0328DOI Listing
February 2019

Expression profile of circular RNAs in placentas of women with gestational diabetes mellitus.

Endocr J 2019 Feb 27. Epub 2019 Feb 27.

Changzhou Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213003, China.

Forty-five pregnant women who underwent cesarean section, including 30 cases of gestational diabetes mellitus (GDM) and 15 normal pregnant women, were enrolled in this study to examine the differential expression of circular RNAs (circRNAs) in the placentas of women with GDM by RNA sequencing (RNA-seq) analysis. The differentially expressed circRNAs were analyzed bioinformatically using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment and circRNA-microRNA (miRNA) interaction prediction. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to verify the results. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0291DOI Listing
February 2019

Upregulated tissue expression of T helper (Th) 17 pathogenic interleukin (IL)-23 and IL-1β in Hashimoto's thyroiditis but not in Graves' disease.

Endocr J 2019 Feb 27. Epub 2019 Feb 27.

Institute of Anatomy and Anthropology, Riga Stradins University, Riga, LV-1010, Latvia.

T helper (Th) 17 cells and interleukin (IL)-17 play a significant role in the pathogenesis of autoimmune thyroid disease (AITD). However, it has recently become clear that Th17 cells are more heterogeneous and exhibit two different phenotypes, whereas IL-23 and IL-1β are crucial for the generation of pathogenic Th17 lymphocytes. We aimed to investigate the association between IL-17 and Th17-promoting cytokines in AITD by studying the immunoexpression patterns of IL-17, IL-23, and IL-1β in thyroid tissue. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0396DOI Listing
February 2019
1 Read

GH/PRL-secreting pituitary macroadenoma associated with GNAS p.Gln227Leu mutation: pediatric case report and review.

Endocr J 2019 Feb 28. Epub 2019 Feb 28.

Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

GH-secreting pituitary adenomas (GHomas) are rare in the pediatric population. Guanine nucleotide-binding protein, alpha stimulating (GNAS) somatic mutations are often found in patients with GHoma. Here, we report an 8-year-old girl with GH-secreting pituitary adenoma successfully treated by operative tumor resection and postoperative treatment with octreotide long-acting release (LAR). Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0370DOI Listing
February 2019

Lipopolysaccharide and inflammatory cytokines levels decreased after sleeve gastrectomy in Chinese adults with obesity.

Endocr J 2019 Feb 22. Epub 2019 Feb 22.

Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Obesity is linked to a low-grade systemic inflammation and lipopolysaccharide (LPS) is a key factor. Sleeve gastrectomy (SG) can significantly cause weight loss, but few reports have looked into the changes of LPS and inflammatory cytokines after surgery. To explore the potential short-term impact of SG on LPS and inflammatory cytokines and their relationship to early metabolic changes in obesity. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0446DOI Listing
February 2019
2 Reads

Characterization of a novel CDC73 gene mutation in a hyperparathyrodism-jaw tumor patient affected by parathyroid carcinoma in the absence of somatic loss of heterozygosity.

Endocr J 2019 Feb 22. Epub 2019 Feb 22.

Department of Surgery and Translational Medicine, University of Florence, Unit of Bone and Mineral Diseases, University Hospital of Florence, Florence 50139, Italy.

Hyperparathyrodism-jaw tumor (HPT-JT) syndrome is an autosomal dominant disorder. Loss of function of the cell division cycle protein 73 homolog (CDC73) gene is responsible for the syndrome. This gene encodes an ubiquitously expressed 531 amino acid protein, parafibromin, that acts as a tumor suppressor. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0387DOI Listing
February 2019
2 Reads

Dihydrotestosterone induces minor transcriptional alterations in genital skin fibroblasts of children with and without androgen insensitivity.

Endocr J 2019 Feb 19. Epub 2019 Feb 19.

Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.

Endogenous and exogenous androgens induce masculinization of external genitalia through binding to the androgen receptor (AR). The target genes of androgens in external genitalia remain to be determined, although previous studies have shown that the apolipoprotein D gene (APOD) was significantly upregulated by dihydrotestosterone (DHT), the most potent androgen in humans. In the present study, we performed microarray analysis for genital skin fibroblasts obtained from four boys with buried penis (the control individuals) and a patient with partial androgen insensitivity syndrome (PAIS) due to a hypomorphic mutation in AR (the PAIS patient). Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0494DOI Listing
February 2019

Outcomes of three-Tesla magnetic resonance imaging for the identification of pituitary adenoma in patients with Cushing's disease.

Endocr J 2019 Mar 14;66(3):259-264. Epub 2019 Feb 14.

Department of Hypothalamic and Pituitary Surgery, Toranomon Hospital, Tokyo 105-8470, Japan.

Pituitary adenoma has been reported to be detectable in only 36-63% of Cushing's disease (CD) patients by magnetic resonance imaging (MRI). In this study, we investigate the outcomes and problems associated with tumor identification using 3-Tesla (3-T) MRI, which provides clearer images than ≤1.5-T MRI, in 115 patients who were initially diagnosed with CD. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0458DOI Listing
March 2019
2 Reads

Clinical characteristics of anti-glutamic acid decarboxylase antibody-positive fulminant type 1 diabetes.

Endocr J 2019 Feb 14. Epub 2019 Feb 14.

Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Saitama, Japan.

This research aimed to examine the relationship between anti-glutamic acid decarboxylase antibody (GADA) titers and clinical parameters at onset and to clarify the association between clinical severity and GADA titers in GADA-positive fulminant type 1 diabetes. This cross-sectional observational study included 20 cases with GADA-positive fulminant type 1 diabetes (4 cases from our hospital and 16 from cases reported in the literature). The association between GADA titers and clinical parameters [age, sex, body weight, body mass index, period from appearance of any prodromal symptoms to diagnosis, period from development of hyperglycemic symptoms to diagnosis, GADA titer, HbA1c level, blood pH and HCO level, serum levels of ketone bodies and pancreatic exocrine enzymes] were analyzed. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0417DOI Listing
February 2019

Body mass index and C-peptide are important for the promptly differential diagnosis of maturity-onset diabetes from familial type 2 diabetes in outpatient clinic.

Endocr J 2019 Feb 13. Epub 2019 Feb 13.

Department of Endocrinology and Metabolism, Hunan provincial Key Laboratory of Metabolic Bone Diseases, National Clinical Research Center for Metabolic Disease, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Type 2 diabetic patients are becoming younger and having a tendency to family aggregation, they are easily suspected as maturity-onset diabetes of young (MODY) in the outpatient clinic and send to genetic testing. 9 diabetic families were compared in our outpatient clinic who met the primary diagnosis criteria of MODY. Detailed clinical features and laboratory data including gene sequence were collected and analyzed. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0560DOI Listing
February 2019
1 Read

The effect of disease activity on thyroid nodules in patients with acromegaly.

Endocr J 2019 Feb 9. Epub 2019 Feb 9.

Department of Endocrinology and Metabolism, Diskapi Teaching and Research Hospital, Ankara, Turkey.

Nodular thyroid disease is a very common disorder in patients with acromegaly. Insulin-like growth factor-1 (IGF-1) is a thyroid growth factor, and there is a correlation between IGF-1 levels and thyroid volume (TV) in patients with acromegaly. There is no study investigating the impact of somatostatin analog (SSA) treatment on thyroid nodule volume in patients with acromegaly. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0502DOI Listing
February 2019
16 Reads

High circulating follistatin-like protein 1 as a biomarker of a metabolically unhealthy state.

Endocr J 2019 Mar 8;66(3):241-251. Epub 2019 Feb 8.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul 06591, Korea.

The inflammatory biomarkers that fully characterize the metabolically unhealthy (MU) state-which is a risk factor for cardiovascular disease (CVD)-remain unclear. Recent studies suggest follistatin-like protein 1 (FSTL1) could be used as a biomarker for inflammation and CVD, however there is little information on FSTL1 levels in the MU state. We aimed to evaluate the associations between FSTL1, the presence of MU state and subclinical coronary atherosclerosis. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0352DOI Listing
March 2019
8 Reads

An assessment of counseling quality provided by community pharmacies to type 2 diabetic adult patients for oral therapy: a simulated patient study from Pakistan.

Endocr J 2019 Mar 5;66(3):233-239. Epub 2019 Feb 5.

Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, Xi'an, P. R. China.

This study was conducted to assess quality of counseling provided to type 2 diabetic patients. For this cross-sectional study, a simulated patient method was applied in 562 selected community pharmacies of Punjab, Pakistan. A scenario for the metformin oral therapy was developed that illustrates direct counseling for adult diabetic patients. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0429DOI Listing

Parathyroid adenoma with prominent lymphocytic infiltrate having histological features highly suggestive of IgG4-related disease: a case report and literature review.

Endocr J 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathology, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Parathyroid adenoma with prominent lymphocytic infiltrate is a rare disease. Until now, 11 patients have been reported. Herein, we report a 57-year-old man who had a neck mass that was incidentally found. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0428DOI Listing
February 2019
3 Reads

Severe hypocalcemia following denosumab treatment in a patient with secondary osteoporosis associated with primary sclerosing cholangitis.

Endocr J 2019 Mar 2;66(3):271-275. Epub 2019 Feb 2.

Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Primary sclerosing cholangitis (PSC) has been known as a cause of secondary osteoporosis, which often requires medication. Herein, we give the first report of a case of a 38-year-old man with fatigue and paralysis in both upper limbs who had been treated with denosumab for secondary osteoporosis associated with PSC. Since bisphosphonate (alendronate) was ineffective in our patient, the treatment was changed from alendronate to denosumab. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0545DOI Listing
March 2019
3 Reads

Pancreatic fat content is associated with β-cell function and insulin resistance in Chinese type 2 diabetes subjects.

Endocr J 2019 Mar 30;66(3):265-270. Epub 2019 Jan 30.

Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Jiangsu, China.

The pathogenesis of type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and β-cell dysfunction. Earlier studies reported that increased levels of pancreatic fat may lead to the development of β-cell dysfunction and insulin resistance. The present study aimed to demonstrate the relationship between pancreatic fat content (PFC) and insulin secretion and insulin resistance in Chinese subjects with T2DM. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0436DOI Listing
March 2019
2.019 Impact Factor

Hyperemesis gravidarum followed by refeeding syndrome causes electrolyte abnormalities induced rhabdomyolysis and diabetes insipidus.

Endocr J 2019 Mar 29;66(3):253-258. Epub 2019 Jan 29.

Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

Although hyperemesis gravidarum (HG), an extreme form of morning sickness, is a common complication during pregnancy, HG associated simultaneous onset of rhabdomyolysis and diabetes insipidus due to electrolyte abnormalities are rare. A 34-year-old woman with severe HG at 17 weeks of gestation complicated with appetite loss, weight reduction by 17 kg, general fatigue, myalgia, weakness and polyuria was identified to have simultaneous hypophosphatemia (1.6 mg/dL) and hypokalemia (2. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0496DOI Listing
March 2019
2 Reads

Language delay and developmental catch-up would be a clinical feature of pseudohypoparathyroidism type 1A during childhood.

Endocr J 2019 Mar 23;66(3):215-221. Epub 2019 Jan 23.

Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Pseudohypoparathyroidism type 1A (PHP1A) is characterized by resistance to multiple hormones, the Albright Hereditary Osteodystrophy phenotype, obesity, and developmental delay. Developmental delay usually appears prior to hypocalcemia due to parathyroid hormone resistance and could be a clinically important feature for early diagnosis of PHP1A. To date, however, the details have not been documented. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0326DOI Listing
March 2019
3 Reads

Changes in glucose metabolism based on 75-g oral glucose tolerance tests before and after surgery for adrenal Cushing's syndrome.

Endocr J 2019 Mar 22;66(3):207-214. Epub 2019 Jan 22.

Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama 222-0036, Japan.

Adrenal Cushing's syndrome (CS) is caused by cortisol-producing adrenal adenoma and is frequently accompanied by glucose metabolism disorders, which are characterized by increased insulin resistance and insufficient β-cell compensation. However, considering the rarity of CS, few studies have assessed whether the glucose metabolism disorders could be ameliorated by surgical treatment. In this case series, we evaluated glucose metabolism before and after surgery in 11 patients (10 women and 1 man) who underwent unilateral adrenalectomy for overt adrenal CS between 2005 and 2016. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0445DOI Listing
March 2019
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Isolated effect of maternal thyroid-stimulating hormone, free thyroxine and antithyroid peroxidase antibodies in early pregnancy on gestational diabetes mellitus: a birth cohort study in China.

Endocr J 2019 Mar 24;66(3):223-231. Epub 2019 Jan 24.

School of Public Health, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

This article aims to understand the isolated effect of maternal thyroid-stimulating hormone (TSH), free thyroxine (FT) and antithyroid peroxidase antibodies (TPOAb) in early pregnancy on gestational diabetes mellitus (GDM). Based on a birth cohort, pregnant women presented to maternity hospitals for the first antenatal care from Nov 2008 to Oct 2010 were invited to participate in the study. A self-administered questionnaire was asked to complete to collect data on socio-economic variables, previous adverse pregnancy outcomes, method of conception, previous endocrinic and metabolic diseases, and pregnancy-related anxiety in 1 trimester of the index pregnancy. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0340DOI Listing
March 2019
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Progesterone governs endometrial proliferation-differentiation switching and blastocyst implantation.

Authors:
Yasushi Hirota

Endocr J 2019 Mar 8;66(3):199-206. Epub 2019 Jan 8.

Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Blastocyst implantation contains the following three processes: apposition, attachment, and invasion of the blastocyst. Ovarian hormone progesterone (P) regulates these processes exquisitely. P-induced molecular communications between the endometrial epithelium and stroma as well as endometrial proliferation-differentiation switching (PDS) until blastocyst attachment are fundamental steps in blastocyst implantation. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0431DOI Listing
March 2019
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Appropriateness of the revised Japanese guidelines' risk classification for the prognosis of papillary thyroid carcinoma: a retrospective analysis of 5,845 papillary thyroid carcinoma patients.

Endocr J 2019 Feb 9;66(2):127-134. Epub 2019 Jan 9.

Department of Surgery, Kuma Hospital, Kobe, Hyogo 650-0011, Japan.

The revised Japan Association of Endocrine Surgeons (JAES)/Japanese Society of Thyroid Surgery (JSTS) guidelines for patients with papillary thyroid carcinoma (PTC) describe four risk classes: very-low-risk, low-risk, intermediate-risk, and high-risk. Here we conducted a retrospective analysis to evaluate the appropriateness of these guidelines' risk classification of PTCs. Lymph node recurrence-free, distant recurrence-free and cause-specific survivals at 15-year of high-risk group were significantly poorer than those at 15-year of intermediate-group and these survivals of intermediate-group were poorer than of low- or very-low-risk patients. Read More

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http://dx.doi.org/10.1507/endocrj.EJ17-0061DOI Listing
February 2019
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Epigenetic regulation of beige adipocyte fate by histone methylation.

Endocr J 2019 Feb 28;66(2):115-125. Epub 2018 Dec 28.

Laboratory of Epigenetics and Metabolism, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan.

Adipose tissue harbors plasticity to adapt to environmental thermal changes. While brown adipocyte is a thermogenic cell which produces heat acutely in response to cold stimuli, beige (or brite) adipocyte is an inducible form of thermogenic adipocytes which emerges in the white adipose depots in response to chronic cold exposure. Such adaptability of adipocytes is regulated by epigenetic mechanisms. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0442DOI Listing
February 2019
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Implications of thyroid autoimmunity in infertile women with subclinical hypothyroidism in the absence of both goiter and anti-thyroid antibodies: lessons from three cases.

Endocr J 2019 Feb 18;66(2):193-198. Epub 2018 Dec 18.

Department of Diabetes, Endocrinology and Metabolism, Division of Internal Medicine, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.

There is a great deal of research interest regarding the underlying causes of slightly elevated TSH values in patients with subclinical hypothyroidism (SH) without abnormal findings on ultrasonography or anti-thyroid antibodies. Twelve infertile women with thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb)-negative nongoitrous SH were referred to our department of endocrinology between September 2007 and September 2015. None had been diagnosed with autoimmune thyroid disease or had any possible causes of SH. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0350DOI Listing
February 2019
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Change of surgical strategy for Graves' disease from subtotal thyroidectomy to total thyroidectomy: a single institutional experience.

Endocr J 2019 Feb 19;66(2):181-186. Epub 2018 Dec 19.

Department of Surgery, Ito Hospital, Tokyo, Japan.

The extent of thyroidectomy in Graves' disease remains controversial. In our institution, long-term euthyroidism without thyroxin replacement therapy has been the aim, and it has long been the standard surgical procedure used to treat Graves' disease in many institutions, including our hospital. Based our several clinical studies, it was concluded that subtotal thyroidectomy is not suitable as a standard surgical procedure for the treatment of Graves' disease. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0324DOI Listing
February 2019
4 Reads

Cyclic Cushing's syndrome caused by neuroendocrine tumor: a case report.

Endocr J 2019 Feb 19;66(2):175-180. Epub 2018 Dec 19.

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China.

Cushing's syndrome (CS) is a clinical syndrome characterized by hypercortisolemia. Cyclic Cushing's syndrome (CCS), which exhibits a periodic or irregular increasing pattern in cortisol, is a rare type of Cushing's syndrome. A 37-year-old man came to our hospital because of repeated dizzy spells, weakness and hypercortisolemia lasting two weeks. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0168DOI Listing
February 2019
20 Reads

Differences in the actions of adrenaline and noradrenaline with regard to glucose intolerance in patients with pheochromocytoma.

Endocr J 2019 Feb 13;66(2):187-192. Epub 2018 Dec 13.

Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka 818-8502, Japan.

Glucose intolerance is often observed in patients with pheochromocytoma. However, it remains controversial issue that glucose intolerance on pheochromocytoma is caused by impaired insulin secretion and/or by increased insulin resistance. We aimed to reveal the mechanism of glucose intolerance on pheochromocytoma with regard to the type and amount of catecholamines released. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0407DOI Listing
February 2019
5 Reads

Interaction of ovarian steroidogenesis and clock gene expression modulated by bone morphogenetic protein-7 in human granulosa cells.

Endocr J 2019 Feb 5;66(2):157-164. Epub 2018 Dec 5.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kitaku, Okayama 700-8558, Japan.

A functional link between clock gene expression and ovarian steroidogenesis was studied using human granulosa KGN cells. Similarities between changes in the mRNA and protein expression levels of Bmal1 and Clock and those of Per2 and Cry1 were found in KGN cells after treatment with forskolin. Among the interrelationships between the expression levels of clock and steroidogenic factors, Clock mRNA had a strongly positive correlation with P450arom and a negative correlation with 3βHSD. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0423DOI Listing
February 2019
17 Reads