3,322 results match your criteria Endocrine Journal [Journal]


Outcomes of three-Tesla magnetic resonance imaging for the identification of pituitary adenoma in patients with Cushing's disease.

Endocr J 2019 Feb 14. Epub 2019 Feb 14.

Department of Hypothalamic and Pituitary Surgery, Toranomon Hospital, Tokyo 105-8470, Japan.

Pituitary adenoma has been reported to be detectable in only 36-63% of Cushing's disease (CD) patients by magnetic resonance imaging (MRI). In this study, we investigate the outcomes and problems associated with tumor identification using 3-Tesla (3-T) MRI, which provides clearer images than ≤1.5-T MRI, in 115 patients who were initially diagnosed with CD. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0458DOI Listing
February 2019

Clinical characteristics of anti-glutamic acid decarboxylase antibody-positive fulminant type 1 diabetes.

Endocr J 2019 Feb 14. Epub 2019 Feb 14.

Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Saitama, Japan.

This research aimed to examine the relationship between anti-glutamic acid decarboxylase antibody (GADA) titers and clinical parameters at onset and to clarify the association between clinical severity and GADA titers in GADA-positive fulminant type 1 diabetes. This cross-sectional observational study included 20 cases with GADA-positive fulminant type 1 diabetes (4 cases from our hospital and 16 from cases reported in the literature). The association between GADA titers and clinical parameters [age, sex, body weight, body mass index, period from appearance of any prodromal symptoms to diagnosis, period from development of hyperglycemic symptoms to diagnosis, GADA titer, HbA1c level, blood pH and HCO level, serum levels of ketone bodies and pancreatic exocrine enzymes] were analyzed. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0417DOI Listing
February 2019

Body mass index and C-peptide are important for the promptly differential diagnosis of maturity-onset diabetes from familial type 2 diabetes in outpatient clinic.

Endocr J 2019 Feb 13. Epub 2019 Feb 13.

Department of Endocrinology and Metabolism, Hunan provincial Key Laboratory of Metabolic Bone Diseases, National Clinical Research Center for Metabolic Disease, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Type 2 diabetic patients are becoming younger and having a tendency to family aggregation, they are easily suspected as maturity-onset diabetes of young (MODY) in the outpatient clinic and send to genetic testing. 9 diabetic families were compared in our outpatient clinic who met the primary diagnosis criteria of MODY. Detailed clinical features and laboratory data including gene sequence were collected and analyzed. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0560DOI Listing
February 2019

The effect of disease activity on thyroid nodules in patients with acromegaly.

Endocr J 2019 Feb 9. Epub 2019 Feb 9.

Department of Endocrinology and Metabolism, Diskapi Teaching and Research Hospital, Ankara, Turkey.

Nodular thyroid disease is a very common disorder in patients with acromegaly. Insulin-like growth factor-1 (IGF-1) is a thyroid growth factor, and there is a correlation between IGF-1 levels and thyroid volume (TV) in patients with acromegaly. There is no study investigating the impact of somatostatin analog (SSA) treatment on thyroid nodule volume in patients with acromegaly. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0502DOI Listing
February 2019
6 Reads

High circulating follistatin-like protein 1 as a biomarker of a metabolically unhealthy state.

Endocr J 2019 Feb 8. Epub 2019 Feb 8.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul 06591, Korea.

The inflammatory biomarkers that fully characterize the metabolically unhealthy (MU) state-which is a risk factor for cardiovascular disease (CVD)-remain unclear. Recent studies suggest follistatin-like protein 1 (FSTL1) could be used as a biomarker for inflammation and CVD, however there is little information on FSTL1 levels in the MU state. We aimed to evaluate the associations between FSTL1, the presence of MU state and subclinical coronary atherosclerosis. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0352DOI Listing
February 2019
3 Reads

An assessment of counseling quality provided by community pharmacies to type 2 diabetic adult patients for oral therapy: a simulated patient study from Pakistan.

Endocr J 2019 Feb 5. Epub 2019 Feb 5.

Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, Xi'an, P. R. China.

This study was conducted to assess quality of counseling provided to type 2 diabetic patients. For this cross-sectional study, a simulated patient method was applied in 562 selected community pharmacies of Punjab, Pakistan. A scenario for the metformin oral therapy was developed that illustrates direct counseling for adult diabetic patients. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0429DOI Listing
February 2019

Parathyroid adenoma with prominent lymphocytic infiltrate having histological features highly suggestive of IgG4-related disease: a case report and literature review.

Endocr J 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathology, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Parathyroid adenoma with prominent lymphocytic infiltrate is a rare disease. Until now, 11 patients have been reported. Herein, we report a 57-year-old man who had a neck mass that was incidentally found. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0428DOI Listing
February 2019
1 Read

Severe hypocalcemia following denosumab treatment in a patient with secondary osteoporosis associated with primary sclerosing cholangitis.

Endocr J 2019 Feb 2. Epub 2019 Feb 2.

Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Primary sclerosing cholangitis (PSC) has been known as a cause of secondary osteoporosis, which often requires medication. Herein, we give the first report of a case of a 38-year-old man with fatigue and paralysis in both upper limbs who had been treated with denosumab for secondary osteoporosis associated with PSC. Since bisphosphonate (alendronate) was ineffective in our patient, the treatment was changed from alendronate to denosumab. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0545DOI Listing
February 2019
1 Read

Pancreatic fat content is associated with β-cell function and insulin resistance in Chinese type 2 diabetes subjects.

Endocr J 2019 Jan 30. Epub 2019 Jan 30.

Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Jiangsu, China.

The pathogenesis of type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and β-cell dysfunction. Earlier studies reported that increased levels of pancreatic fat may lead to the development of β-cell dysfunction and insulin resistance. The present study aimed to demonstrate the relationship between pancreatic fat content (PFC) and insulin secretion and insulin resistance in Chinese subjects with T2DM. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0436DOI Listing
January 2019

Hyperemesis gravidarum followed by refeeding syndrome causes electrolyte abnormalities induced rhabdomyolysis and diabetes insipidus.

Endocr J 2019 Jan 29. Epub 2019 Jan 29.

Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

Although hyperemesis gravidarum (HG), an extreme form of morning sickness, is a common complication during pregnancy, HG associated simultaneous onset of rhabdomyolysis and diabetes insipidus due to electrolyte abnormalities are rare. A 34-year-old woman with severe HG at 17 weeks of gestation complicated with appetite loss, weight reduction by 17 kg, general fatigue, myalgia, weakness and polyuria was identified to have simultaneous hypophosphatemia (1.6 mg/dL) and hypokalemia (2. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0496DOI Listing
January 2019
1 Read

Language delay and developmental catch-up would be a clinical feature of pseudohypoparathyroidism type 1A during childhood.

Endocr J 2019 Jan 23. Epub 2019 Jan 23.

Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Pseudohypoparathyroidism type 1A (PHP1A) is characterized by resistance to multiple hormones, the Albright Hereditary Osteodystrophy phenotype, obesity, and developmental delay. Developmental delay usually appears prior to hypocalcemia due to parathyroid hormone resistance and could be a clinically important feature for early diagnosis of PHP1A. To date, however, the details have not been documented. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0326DOI Listing
January 2019
2 Reads

Changes in glucose metabolism based on 75-g oral glucose tolerance tests before and after surgery for adrenal Cushing's syndrome.

Endocr J 2019 Jan 22. Epub 2019 Jan 22.

Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama 222-0036, Japan.

Adrenal Cushing's syndrome (CS) is caused by cortisol-producing adrenal adenoma and is frequently accompanied by glucose metabolism disorders, which are characterized by increased insulin resistance and insufficient β-cell compensation. However, considering the rarity of CS, few studies have assessed whether the glucose metabolism disorders could be ameliorated by surgical treatment. In this case series, we evaluated glucose metabolism before and after surgery in 11 patients (10 women and 1 man) who underwent unilateral adrenalectomy for overt adrenal CS between 2005 and 2016. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0445DOI Listing
January 2019
2 Reads

Isolated effect of maternal thyroid-stimulating hormone, free thyroxine and antithyroid peroxidase antibodies in early pregnancy on gestational diabetes mellitus: a birth cohort study in China.

Endocr J 2019 Jan 24. Epub 2019 Jan 24.

School of Public Health, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

This article aims to understand the isolated effect of maternal thyroid-stimulating hormone (TSH), free thyroxine (FT) and antithyroid peroxidase antibodies (TPOAb) in early pregnancy on gestational diabetes mellitus (GDM). Based on a birth cohort, pregnant women presented to maternity hospitals for the first antenatal care from Nov 2008 to Oct 2010 were invited to participate in the study. A self-administered questionnaire was asked to complete to collect data on socio-economic variables, previous adverse pregnancy outcomes, method of conception, previous endocrinic and metabolic diseases, and pregnancy-related anxiety in 1 trimester of the index pregnancy. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0340DOI Listing
January 2019
1 Read

Progesterone governs endometrial proliferation-differentiation switching and blastocyst implantation.

Authors:
Yasushi Hirota

Endocr J 2019 Jan 8. Epub 2019 Jan 8.

Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Blastocyst implantation contains the following three processes: apposition, attachment, and invasion of the blastocyst. Ovarian hormone progesterone (P) regulates these processes exquisitely. P-induced molecular communications between the endometrial epithelium and stroma as well as endometrial proliferation-differentiation switching (PDS) until blastocyst attachment are fundamental steps in blastocyst implantation. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0431DOI Listing
January 2019
1 Read

Appropriateness of the revised Japanese guidelines' risk classification for the prognosis of papillary thyroid carcinoma: a retrospective analysis of 5,845 papillary thyroid carcinoma patients.

Endocr J 2019 Jan 9. Epub 2019 Jan 9.

Department of Surgery, Kuma Hospital, Kobe, Hyogo 650-0011, Japan.

The revised Japan Association of Endocrine Surgeons (JAES)/Japanese Society of Thyroid Surgery (JSTS) guidelines for patients with papillary thyroid carcinoma (PTC) describe four risk classes: very-low-risk, low-risk, intermediate-risk, and high-risk. Here we conducted a retrospective analysis to evaluate the appropriateness of these guidelines' risk classification of PTCs. Lymph node recurrence-free, distant recurrence-free and cause-specific survivals at 15-year of high-risk group were significantly poorer than those at 15-year of intermediate-group and these survivals of intermediate-group were poorer than of low- or very-low-risk patients. Read More

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http://dx.doi.org/10.1507/endocrj.EJ17-0061DOI Listing
January 2019
1 Read

Epigenetic regulation of beige adipocyte fate by histone methylation.

Endocr J 2018 Dec 28. Epub 2018 Dec 28.

Laboratory of Epigenetics and Metabolism, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan.

Adipose tissue harbors plasticity to adapt to environmental thermal changes. While brown adipocyte is a thermogenic cell which produces heat acutely in response to cold stimuli, beige (or brite) adipocyte is an inducible form of thermogenic adipocytes which emerges in the white adipose depots in response to chronic cold exposure. Such adaptability of adipocytes is regulated by epigenetic mechanisms. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0442DOI Listing
December 2018
1 Read

Implications of thyroid autoimmunity in infertile women with subclinical hypothyroidism in the absence of both goiter and anti-thyroid antibodies: lessons from three cases.

Endocr J 2018 Dec 18. Epub 2018 Dec 18.

Department of Diabetes, Endocrinology and Metabolism, Division of Internal Medicine, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.

There is a great deal of research interest regarding the underlying causes of slightly elevated TSH values in patients with subclinical hypothyroidism (SH) without abnormal findings on ultrasonography or anti-thyroid antibodies. Twelve infertile women with thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb)-negative nongoitrous SH were referred to our department of endocrinology between September 2007 and September 2015. None had been diagnosed with autoimmune thyroid disease or had any possible causes of SH. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0350DOI Listing
December 2018
2 Reads

Change of surgical strategy for Graves' disease from subtotal thyroidectomy to total thyroidectomy: a single institutional experience.

Endocr J 2018 Dec 19. Epub 2018 Dec 19.

Department of Surgery, Ito Hospital, Tokyo, Japan.

The extent of thyroidectomy in Graves' disease remains controversial. In our institution, long-term euthyroidism without thyroxin replacement therapy has been the aim, and it has long been the standard surgical procedure used to treat Graves' disease in many institutions, including our hospital. Based our several clinical studies, it was concluded that subtotal thyroidectomy is not suitable as a standard surgical procedure for the treatment of Graves' disease. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0324DOI Listing
December 2018
3 Reads

Cyclic Cushing's syndrome caused by neuroendocrine tumor: a case report.

Endocr J 2018 Dec 19. Epub 2018 Dec 19.

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China.

Cushing's syndrome (CS) is a clinical syndrome characterized by hypercortisolemia. Cyclic Cushing's syndrome (CCS), which exhibits a periodic or irregular increasing pattern in cortisol, is a rare type of Cushing's syndrome. A 37-year-old man came to our hospital because of repeated dizzy spells, weakness and hypercortisolemia lasting two weeks. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0168DOI Listing
December 2018
12 Reads

Differences in the actions of adrenaline and noradrenaline with regard to glucose intolerance in patients with pheochromocytoma.

Endocr J 2018 Dec 13. Epub 2018 Dec 13.

Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka 818-8502, Japan.

Glucose intolerance is often observed in patients with pheochromocytoma. However, it remains controversial issue that glucose intolerance on pheochromocytoma is caused by impaired insulin secretion and/or by increased insulin resistance. We aimed to reveal the mechanism of glucose intolerance on pheochromocytoma with regard to the type and amount of catecholamines released. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0407DOI Listing
December 2018
2 Reads

Interaction of ovarian steroidogenesis and clock gene expression modulated by bone morphogenetic protein-7 in human granulosa cells.

Endocr J 2018 Dec 5. Epub 2018 Dec 5.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kitaku, Okayama 700-8558, Japan.

A functional link between clock gene expression and ovarian steroidogenesis was studied using human granulosa KGN cells. Similarities between changes in the mRNA and protein expression levels of Bmal1 and Clock and those of Per2 and Cry1 were found in KGN cells after treatment with forskolin. Among the interrelationships between the expression levels of clock and steroidogenic factors, Clock mRNA had a strongly positive correlation with P450arom and a negative correlation with 3βHSD. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0423DOI Listing
December 2018
10 Reads

Intraoperative rapid aspiration cytological method for parathyroid glands identification and protection.

Endocr J 2018 Dec 5. Epub 2018 Dec 5.

Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.

To explore new methods for intraoperative identification of parathyroid glands, 86 thyroid cancer patients, admitted to Xijing hospital from July 2017 to July 2018, were included. During lymph node dissection, parathyroid glands were firstly judged by clinician eyeballing, based on his clinical experience. Then, cytological detection was used for rapid identification via Diff-quik staining. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0363DOI Listing
December 2018
2 Reads
2.019 Impact Factor

Ectopic fat, insulin resistance and metabolic disease in non-obese Asians: investigating metabolic gradation.

Authors:
Yoshifumi Tamura

Endocr J 2019 Jan 4;66(1):1-9. Epub 2018 Dec 4.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Although metabolic abnormalities commonly occur in non-obese Asians, their pathogenesis is not fully understood. Proton magnetic resonance spectroscopy has been used to analyze intracellular lipids in humans, and results suggest that ectopic fat accumulation in muscle and liver may induce insulin resistance in each tissue independently of obesity. Thus, measurement of ectopic fat currently plays an important role in the study of insulin resistance in non-obese Asians. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0435DOI Listing
January 2019
14 Reads

Risk factors for postoperative cardiovascular morbidity after pheochromocytoma surgery: a large single center retrospective analysis.

Endocr J 2018 Dec 4. Epub 2018 Dec 4.

Department of Urology, ShengJing Hospital of China Medical University, Shenyang 110004, China.

Surgical resection is the primary treatment strategy for pheochromocytoma; however, it carries a high risk of morbidity and mortality, especially with respect to cardiovascular complications, which is the most common kinds of morbidity. The risk factors for morbidity remain unclear and require further exploration, moreover no studies focus on risk factors for cardiovascular morbidity. Herein we identified the risk factors for cardiovascular morbidity after pheochromocytoma surgery in Chinese patients. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0402DOI Listing
December 2018
5 Reads

Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide.

Endocr J 2018 Nov 30. Epub 2018 Nov 30.

Department of Molecular and Cellular Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Diazoxide is recognized as an effective medical treatment for insulinoma. However, due to its adverse effects, such as fluid retention, it is sometimes difficult to employ diazoxide at an effective dose in clinical practice. This study aimed to clarify the clinical factors, which may affect efficacy and safety of the diazoxide treatment. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0353DOI Listing
November 2018
7 Reads

Optimal needle size for thyroid fine needle aspiration cytology.

Endocr J 2018 Nov 21. Epub 2018 Nov 21.

Department of Surgery, Kuma Hospital, Kobe, Japan.

Concerning the needle size for thyroid fine needle aspiration cytology (FNAC), 25-27-gauge needles are generally used in Western countries. However, in Japan, the use of larger needles (21-22-gauge needles) is common. The aim of our study was to determine the optimal needle size for thyroid FNAC. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0422DOI Listing
November 2018
15 Reads

Effects of a diet with or without physical activity on angiopoietin-like protein 8 concentrations in overweight/obese patients with newly diagnosed type 2 diabetes: a randomized controlled trial.

Endocr J 2019 Jan 15;66(1):89-105. Epub 2018 Nov 15.

Department of Endocrinology, the First People's Hospital of Xuzhou, Jiangsu 221002, China.

Angiopoietin-like protein 8 (ANGPTL8) is a newly discovered adipokine plays an important role in energy homoeostasis, obesity and type 2 diabetes (T2D). Although lifestyle modification in obesity and T2D is known to offer metabolic benefits, there is paucity of comprehensive data on change in ANGPTL8. We investigated the effect of lifestyle intervention on ANGPTL8 concentrations. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0191DOI Listing
January 2019
7 Reads

Premature ovarian insufficiency may be associated with the mutations in mitochondrial tRNA genes.

Endocr J 2019 Jan 6;66(1):81-88. Epub 2018 Nov 6.

Central Laboratory, Hangzhou First People's Hospital, Zhejiang University, School of Medicine, Hangzhou, 310006, China.

Premature ovarian insufficiency (POI) is a common endocrine disorder featured by the triad constituting of amenorrhea for at least four months, to date, the molecular pathogenesis of POI is largely undetermined. Despite several investigations have reported an increase in reactive oxygen species (ROS) content in idiopathic POI, the role of mitochondrial DNA (mtDNA) mutations/variants in the progression of POI has not been widely investigated. The current study aimed to explore the association between mt-tRNA mutations/variants and POI; we first used the PCR-Sanger sequencing to detect the mutations/variants in mt-tRNA genes from 50 POI patients and 30 healthy subjects. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0308DOI Listing
January 2019
2 Reads

Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2.

Endocr J 2019 Jan 2;66(1):107-114. Epub 2018 Nov 2.

Department of Diabetes and Metabolism, Tohoku University Hospital, Sendai, Miyagi 980-8575, Japan.

Soft-drink diabetic ketosis, characterized by acute onset ketosis induced by excessive ingestion of sugar-containing drinks, is often seen in obese, young patients, even with undiagnosed type 2 diabetes. We herein report a 15-year-old obese patient with the apolipoprotein E4/2 phenotype, in whom eruptive xanthomas lead to a diagnosis of soft-drink diabetic ketosis. He developed multiple asymptomatic yellowish papules on the auricles, back, buttocks and the extensor surfaces of the elbows and knees. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0356DOI Listing
January 2019
16 Reads

Association of the muscle/fat mass ratio with insulin resistance in gestational diabetes mellitus.

Endocr J 2019 Jan 3;66(1):75-80. Epub 2018 Nov 3.

Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.

This study assessed the association of muscle mass with insulin resistance, evaluated from the insulin sensitivity index (ISI), in Japanese patients with gestational diabetes mellitus (GDM). Consecutive patients with GDM (n = 96) admitted to St. Marianna University Hospital between October 2015 and March 2018 for initial education and glycemic control were enrolled in a prospective observational study. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0252DOI Listing
January 2019
10 Reads

Effect of ipragliflozin on liver function in Japanese type 2 diabetes mellitus patients: a subgroup analysis of the STELLA-LONG TERM study (3-month interim results).

Endocr J 2019 Jan 3;66(1):31-41. Epub 2018 Nov 3.

Astellas Pharma Inc., Chuo-ku, Tokyo 103-8411, Japan.

This subgroup analysis of STELLA-LONG TERM, an ongoing 3-year post-marketing surveillance study on the long-term efficacy and safety of ipragliflozin, assessed the effect of ipragliflozin on liver function in type 2 diabetes mellitus (T2DM) patients. Patients were divided according to baseline liver function (normal [male: ALT ≤30, female: ALT ≤20], abnormal [male: ALT ≥31, female: ALT ≥21]). We evaluated changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (γ-GTP), alkaline phosphatase (ALP), and fatty liver index (FLI) at 3 months of treatment; the proportion of patients with abnormal liver function whose liver function normalized after 3 months of treatment; and correlations between changes in ALT levels and efficacy variables/laboratory values. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0217DOI Listing
January 2019
3 Reads

Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis.

Endocr J 2019 Jan 3;66(1):51-63. Epub 2018 Nov 3.

Department of Epidemiology and Biostatistics, Guangdong Medical University, Dongguan 523808, China.

We conducted a systematic review and meta-analysis to evaluate the effect of Berberine on glucose in patients with type 2 diabetes mellitus and identify potential factors may modifying the hypoglycemic effect. We searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database to identify randomized controlled trials that investigated the effect of Berberine. We calculated weighted mean differences (WMD) and 95% confidence interval (CI) for fasting plasma glucose (FPG), postprandial plasma glucose (PPG) and glycated haemoglobin (HbA1c) levels. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0109DOI Listing
January 2019
17 Reads

Functional analysis of monocarboxylate transporter 8 mutations in Japanese Allan-Herndon-Dudley syndrome patients.

Endocr J 2019 Jan 25;66(1):19-29. Epub 2018 Oct 25.

Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Japan.

Monocarboxylate transporter 8 (MCT8) facilitates T3 uptake into cells. Mutations in MCT8 lead to Allan-Herndon-Dudley syndrome (AHDS), which is characterized by severe psychomotor retardation and abnormal thyroid hormone profile. Nine uncharacterized MCT8 mutations in Japanese patients with severe neurocognitive impairment and elevated serum T3 levels were studied regarding the transport of T3. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0251DOI Listing
January 2019
2 Reads

Erratum.

Authors:

Endocr J 2018 ;65(10):1069

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http://dx.doi.org/10.1507/endocrj.EJ65-10_ErratumDOI Listing
January 2018
1 Read

Cohort study exploring the effect of lenvatinib on differentiated thyroid cancer.

Endocr J 2018 Nov 24;65(11):1071-1074. Epub 2018 Oct 24.

National Hospital Organization, Higashinagoya National Hospital, Nagoya, Aichi 465-8620, Japan.

Lenvatinib is a molecular-targeting agent that was recently approved in Japan for treatment of curatively unresectable, radioactive iodine-refractory, progressive differentiated thyroid cancer (DTC). Because only a few Japanese patients have received lenvatinib in clinical trials, there are limited domestic data on its safety and efficacy or prognostic factors. Therefore, a prospective observational study has been designed to collect safety and efficacy data in at least 300 patients with curatively unresectable DTC receiving lenvatinib therapy (24 mg/day), in order to find predictors of antitumor activity and survival. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0261DOI Listing
November 2018
1 Read

Flightless-I mediates the repression of estrogen receptor α target gene expression by the glucocorticoid receptor in MCF-7 cells.

Endocr J 2019 Jan 26;66(1):65-74. Epub 2018 Oct 26.

Gachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.

The human homologue of flightless-I (FLII) belong to the gelsolin protein family and contain a gelsolin-like domain at the C-terminus and a leucine-rich repeat (LRR) domain at the N-terminus. FLII regulates estrogen receptor alpha (ERα) and glucocorticoid receptor (GR)-mediated transcription by direct interaction through different domains, suggestive of its potential role in the crosstalk between the ERα and GR signaling pathway. Here, we demonstrate that FLII plays a critical role in GR-mediated repression of ERα target gene expression. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0343DOI Listing
January 2019
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Suppression of free fatty acid receptor 1 expression in pancreatic β-cells in obese type 2 diabetic db/db mice: a potential role of pancreatic and duodenal homeobox factor 1.

Endocr J 2019 Jan 17;66(1):43-50. Epub 2018 Oct 17.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.

It is known that long-chain fatty acids bind to free fatty acid receptor 1 (Ffar1), also known as G protein-coupled receptor 40 (GPR40), and amplify glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells and that Ffar1 agonists facilitates insulin secretion and ameliorates glycemic control. On the other hands, pancreatic and duodenal homeobox factor 1 (Pdx1) is an important transcription factor for various β-cell-related genes including insulin gene and thereby contributes to the maintenance of mature β-cell function. The aim of this study was to evaluate how Ffar1 expression in β-cells is altered under diabetic conditions. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0203DOI Listing
January 2019
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Estrogen signaling increases nuclear receptor subfamily 4 group A member 1 expression and energy production in skeletal muscle cells.

Endocr J 2018 Dec 17;65(12):1209-1218. Epub 2018 Oct 17.

Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama 350-1241, Japan.

Estrogen deficiency has been known to associate with musculoskeletal diseases in women, based on the clinical observations of frequent susceptibility to osteoporosis and sarcopenia among postmenopausal women. In skeletal muscles, estrogen has been assumed to play physiological roles in maintaining muscle mass and strength, although its precise molecular mechanism remains to be elucidated. We have previously shown that estrogen regulates energy metabolism through the downregulation of mitochondrial uncoupling protein 3 (UCP3) in skeletal muscles, which may contribute to the prolonged exercise endurance in female mice. Read More

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http://dx.doi.org/10.1507/endocrj.EJ17-0548DOI Listing
December 2018
3 Reads
2.020 Impact Factor

Lower serum total bilirubin concentration is associated with higher prevalence of gestational diabetes mellitus in Japanese pregnant women.

Endocr J 2018 Dec 10;65(12):1199-1208. Epub 2018 Oct 10.

Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.

We aimed to clarify the pathophysiological significance of total bilirubin (TB) in gestational diabetes mellitus (GDM). This was a cross-sectional study that included 616 pregnant Japanese women (368 normal glucose tolerance [NGT] and 248 GDM). Serum TB concentration, homeostasis model assessment of insulin resistance (HOMA-IR), and other clinical parameters were compared in NGT and GDM women. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ17-0533DOI Listing
December 2018
3 Reads

Different daily glycemic profiles after switching from once-daily alogliptin plus twice-daily metformin to their once-daily fixed-dose combination in Japanese type 2 diabetic patients.

Endocr J 2019 Jan 11;66(1):11-17. Epub 2018 Oct 11.

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

The aim of this study was to investigate whether daily glycemic profiles and treatment satisfaction would be changed after switching from once-daily 25-mg alogliptin plus twice-daily 250-mg metformin to the fixed-dose combination of 25-mg alogliptin and 500-mg metformin once daily in type 2 diabetic patients. Twenty adult Japanese type 2 diabetic patients in whom once-daily 25-mg alogliptin plus twice-daily 250-mg metformin were switched to the fixed-dose combination of 25-mg alogliptin and 500-mg metformin once daily participated. Before and one month after the switch, participants were asked to perform one day of seven-point self-monitoring of blood glucose (SMBG), to wear a sensor of flash glucose monitoring for up to 14 days, and to respond to a questionnaire for treatment satisfaction. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0313DOI Listing
January 2019
17 Reads

Structure and function analysis of adiponectin receptors toward development of novel antidiabetic agents promoting healthy longevity.

Endocr J 2018 Oct 3;65(10):971-977. Epub 2018 Oct 3.

Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Plasma adiponectin levels and expression of its receptors, AdipoRs are decreased in obesity, which cause insulin resistance and diabetes. AdipoR-deficient mice exhibit insulin resistance and impaired glucose tolerance. Moreover, newly identified AdipoR agonists not only improve insulin resistance but prolong lifespan shortened by obesity via AdipoR. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0310DOI Listing
October 2018
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Impact of the modification of the diagnostic criteria in the 2017 Bethesda System for Reporting Thyroid Cytopathology: a report of a single institution in Japan.

Endocr J 2018 Dec 3;65(12):1193-1198. Epub 2018 Oct 3.

Department of Surgery, Kuma Hospital, Kobe, Hyogo, Japan.

The Bethesda System for Reporting Thyroid Cytopathology has recently been revised in 2017 (TBSRTC 2017). This study aimed to evaluate the impact of modifying the diagnostic criteria in TBSRTC 2017 at a single institute. We retrospectively reviewed cytological specimens of 10,399 thyroid nodules submitted for thyroid fine-needle aspiration cytology. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0290DOI Listing
December 2018
8 Reads

Erratum.

Authors:

Endocr J 2018 ;65(9):969

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http://dx.doi.org/10.1507/endocrj.EJ65-9_ErratumDOI Listing
January 2018
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Rescue of the fetal damage associated with high intrauterine pressure by 17β-estradiol injection in ovariectomized progesterone-treated pregnant mice.

Endocr J 2018 Dec 19;65(12):1219-1224. Epub 2018 Sep 19.

Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598-8531, Japan.

The present study examined the effects of progesterone (P) and 17β-estradiol (E2) on fetal damage and intrauterine pressure in ovariectomized pregnant mice. The mice were ovariectomized on gestational day (GD) 9 (copulation plug = GD 0), and daily subcutaneous injection of various doses of P (2, 3 or 4 mg) or 4 mg P plus E2 (0.05 or 0. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0302DOI Listing
December 2018
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A case of ectopic ACTH syndrome due to DDAVP-sensitive but V1b receptor-negative bronchial typical carcinoid with lymphatic metastasis and plasma ProGRP elevation.

Endocr J 2018 Dec 20;65(12):1161-1169. Epub 2018 Sep 20.

Department of Diabetes and Endocrinology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.

Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation. Here, we report a 47-year-old female smoker with progressive typical carcinoid and plasma ProGRP elevation. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0052DOI Listing
December 2018
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The effect of diet control on puberty onset and immunoreactivity of kisspeptin and neurokinin B in female rats.

Endocr J 2018 Dec 14;65(12):1177-1185. Epub 2018 Sep 14.

Department of Anatomy, School of Medicine, Chosun University, Gwang-ju, Korea.

Early onset puberty and irregular estrous cycles occur more frequently in rats which are fed a high-fat diet. Kisspeptin is an essential factor for the regulation of sexual maturation and is co-expressed with neurokinin B in neurons in the hypothalamic arcuate nucleus. However, the effects of a diet change on kisspeptin neuronal signaling are not well-understood. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0181DOI Listing
December 2018
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Spontaneous virilization around puberty in NR5A1-related 46,XY sex reversal: additional case and a literature review.

Endocr J 2018 Dec 15;65(12):1187-1192. Epub 2018 Sep 15.

Department of Endocrinology and Metabolism, Kanagawa Children's Medical Center, Yokohama 232-8555, Japan.

A heterozygous NR5A1 mutation is one of the most frequent causes of 46,XY DSD (disorders of sex development). We here reported a NR5A1-related 46,XY DSD patient, who first received endocrinological attention at 10 years of age for clitoromegaly. The patient had been reared as a girl, and no signs of virilization had been detected before. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0218DOI Listing
December 2018
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Utility of monoclonal PAX8 antibody for distinguishing intrathyroid thymic carcinoma from follicular cell-derived thyroid carcinoma.

Endocr J 2018 Dec 12;65(12):1171-1175. Epub 2018 Sep 12.

Department of Surgery, Kuma Hospital, Kobe, Hyogo 650-0011, Japan.

Follicular cell-derived thyroid carcinomas, including thyroid squamous cell carcinomas (SCCs) and anaplastic carcinomas, are immunoreactive for paired-box gene 8 (PAX8), while non-follicular cell-derived thyroid carcinomas stain negative for the PAX8 antibody. Intrathyroid thymic carcinoma (ITTC) arising from the intrathyroidal ectopic thymus exhibits moderate-to-strong nuclear reactivity for polyclonal PAX8. This is difficult to understand given that PAX8 is not associated with embryonic thymic development. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0282DOI Listing
December 2018
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Vanishing of ruptured adrenal mass with takotsubo cardiomyopathy.

Endocr J 2018 Dec 8;65(12):1155-1159. Epub 2018 Sep 8.

Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8640, Japan.

A 45-year-old male suddenly experienced left-flank abdominal pain. Echocardiography revealed akinesis of the 'takotsubo cardiomyopathy' type. He experienced a sudden haemodynamic collapse (blood pressure, 324/154 mmHg; pulse rate, 180 beats/min) during emergency cardiac catheterisation. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0119DOI Listing
December 2018
8 Reads

Pharmacokinetics of insulin disappearance after massive overdosing.

Endocr J 2018 Nov 4;65(11):1147-1153. Epub 2018 Sep 4.

Diabetes Center, Aizawa Hospital, Matsumoto, 390-8510, Japan.

Long-term glucose supplementation is required to prevent hypoglycemia after massive insulin overdosing. We fitted the blood insulin concentration-time profile to the model: I = A·exp + B·exp, where I (μU/mL) is the serum/plasma insulin concentration, A (μU/mL) and B (μU/mL) are the peak insulin concentrations of each component, a (time) and b (time) are the time constants of each component, and t (h) is the time elapsed from the peak of blood insulin level. Additional components were considered as needed. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0118DOI Listing
November 2018
2 Reads