41,700 results match your criteria Endocarditis

What Factors Should Be Considered to Improve Outcome of Mechanical Mitral Valve Replacement in Children?

World J Pediatr Congenit Heart Surg 2021 May;12(3):367-374

Department of Cardiovascular Surgery, 4352Mayo Clinic, Rochester, MN, USA.

Objective: To identify risk factors for pediatric mechanical mitral valve replacement (mMVR) to improve management in this challenging population.

Methods: From 1993 to 2019, 93 children underwent 119 mMVR operations (median age, 8.8 years [interquartile range [IQR]: 2. Read More

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Brucella involving the heart: a hidden disease.

Int J Cardiovasc Imaging 2021 May 3. Epub 2021 May 3.

Internal Medicine Department, Division of Infectious Diseases, Faculty of Medical Sciences, Notre Dame, Secours University Hospital Jbeil and the Holy Spirit University of Kaslik, Rue 93, Hboub- St Charbel, B.P.3, Jbeil, Lebanon.

Brucellosis is a multisystemic disease with serious cardiac involvement mainly endocarditis. It is a lethal but rare complication involving congenital, prosthetic and even native valves. Positive hemoculture confirm the diagnosis. Read More

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PR interval prolongation is significantly associated with aortic root abscess: An age- And gender-matched study.

Ann Noninvasive Electrocardiol 2021 May 3:e12849. Epub 2021 May 3.

Heart & Vascular Center, Pritzker School of Medicine of the University of Chicago, Chicago, IL, USA.

Background: Electrocardiographic abnormalities, such as PR interval prolongation, have been anecdotally reported in patients with aortic root abscess (ARA). An electrocardiographic marker may be useful in identifying those patients with aortic valve endocarditis who may progress to ARA. The objective of this study is to evaluate the change in the PR interval in patients with surgically confirmed ARA and compare it to age- and gender-matched controls with echocardiographically or surgically confirmed aortic valve endocarditis but without aortic root abscess and those hospitalized with diagnoses other than endocarditis. Read More

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Mitral kissing lesion with anterior mitral leaflet aneurysm in a child.

Ann Card Anaesth 2021 Jan-Mar;24(1):108-110

Department of Cardiac Anasthesia, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

Aortic valve endocarditis can lead to secondary involvement of aorto mitral curtain and the adjacent anterior mitral leaflet (AML). The secondary damage to AML is often caused by the infected diastolic jet of aortic regurgitation hitting the ventricular surface of the anterior mitral leaflet, or by the pronounced bacterial vegetation that prolapses from the aortic valve into the left ventricular outflow tract. This is called "kissing lesion". Read More

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Successful medical management of fungal infective endocarditis post VSD closure.

Ann Card Anaesth 2021 Jan-Mar;24(1):95-98

Department of Anaesthesia and Intensive Care, PGIMER, Chandigarh, India.

Fungal infective endocarditis (IE) is uncommon in postoperative cardiac surgical patients. The fungal IE accounts for 1.3'-6. Read More

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Incidentally found guidewire during bacterial endocarditis workup.

Ann Card Anaesth 2021 Jan-Mar;24(1):77-78

Echocardiography Laboratory, Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, FL, USA.

A 67-year-old female with recent hospitalization for pneumonia was transferred to our facility for high fevers and positive blood cultures for staph aureus. During her treatment for pneumonia, central venous catheter was placed. A systolic murmur was found in conjunction with fever and notable premature ventricular contractions on telemetry monitoring. Read More

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Moxifloxacin Monotherapy in Left-Sided Endocarditis.

Yucel Colkesen

Case Rep Infect Dis 2021 14;2021:5586450. Epub 2021 Apr 14.

Department of Cardiology, Erdem Hospital, Istanbul, Turkey.

is the major cause of endocarditis, and its mortality has remained high despite therapeutic procedures over time. A case of left-sided native valve endocarditis caused by methicillin-sensitive which responded well to moxifloxacin monotherapy is described. An 83-year-old woman with a history of current hospitalization presented with fatigue and fever. Read More

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Catheter-related giant right atrial thrombosis mimicking a myxoma: A case report.

Exp Ther Med 2021 Jun 14;21(6):603. Epub 2021 Apr 14.

Department of Cardiovascular Surgery, 'Prof. Dr. C. C.' Iliescu Emergency Institute for Cardiovascular Diseases, 022322 Bucharest, Romania.

Despite the development of imagistic methods, the differential diagnosis of a right atrial mass may be difficult to be established, the most common pathologies which should be taken in consideration being represented by thrombus, tumors, prominent crista terminalis, or vegetation of infectious endocarditis. In this study, we present the case of a 63-year-old man with chronic kidney disease, in hemodialysis (HD) with a silicone central venous catheter (CVC) with the incidental transthoracic echocardiography (transthoracic echocardiogram, TTE) finding of a tumoral mass of 35x26 mm in the right atrium (RA), not related with the catheter, which was diagnosed as right atrial myxoma and underwent surgical excision. After reviewing the histopathology probe, the diagnosis of right atrial thrombus was confirmed. Read More

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Infective endocarditis with neurological complications: Delaying cardiac surgery is associated with worse outcome.

Arch Cardiovasc Dis 2021 Apr 29. Epub 2021 Apr 29.

AP-HM, La Timone Hospital, Cardiology Department, 13005 Marseille, France; Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU-Méditerranée Infection, 13005 Marseille, France. Electronic address:

Background: Infective endocarditis (IE) is associated with a high mortality rate, related in part to neurological complications. Studies suggest that valvular surgery should be performed early when indicated, but is often delayed by the presence of neurological complications.

Aim: To assess the effect of delaying surgery in patients with IE and neurological complications and to identify factors predictive of death. Read More

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Prolonged cefazolin course for treatment of methicillin susceptible staphylococcus species infections and the impact on the emergence of multidrug-resistant bacteria during cloxacillin shortage.

Infect Dis Now 2021 May 31;51(3):304-307. Epub 2020 Dec 31.

Infectious Diseases Department, Centre Hospitalier de la Côte Basque, 13, av. de l'Interne J. Loeb, Bayonne, France.

Objectives: To describe the efficacy and safety of prolonged cefazolin course for Staphylococcus infection and the emergence of multidrug-resistant bacteria carriage after treatment.

Methods: Monocentric retrospective cohort study of patients hospitalized for blood stream infections (BSI) and osteoarticular infections (OAI) by methicillin susceptible staphylococcal species treated with cefazolin from January 2015 to July 2017. Rectal and nasal swabs were performed at cefazolin initiation and end of treatment to detect respectively methicillin resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL) producing bacteria. Read More

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Infective endocarditis and outcomes of mitral valve replacement.

Eur J Clin Invest 2021 May 1:e13577. Epub 2021 May 1.

Heart Center, Turku University Hospital and University of Turku, Turku, Finland.

Background: We investigated the long-term outcomes of mitral valve replacement (MVR) in native mitral valve infective endocarditis (IE).

Methods: Multicentre, population-based cohort register study consisted of 1233 consecutive adult patients treated with first-time MVR in Finland. Mitral valve IE was diagnosed in 170 of these patients. Read More

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: An Unexpected Cause of Polyarthritis and Meningitis.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211012194

University of Florida College of Medicine, Jacksonville, FL, USA.

, a gram-negative coccus, is a major cause of morbidity among sexually active individuals. Hematogenous spread of from the initial site of infection is thought to occur in only 0.5% to 3% of infected patients. Read More

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Active Infective Native and Prosthetic Valve Endocarditis: Short- and Long-Term Outcomes of Patients after Surgical Treatment.

J Clin Med 2021 Apr 26;10(9). Epub 2021 Apr 26.

Department of Cardiovascular Surgery, Christian-Albrechts-University of Kiel, School of Medicine, Arnold-Heller-Str. 3, D-24105 Kiel, Germany.

Background: Active infective endocarditis (IE) is a serious disease associated with high mortality. The current study represents our experience over 18 years with surgical treatment for active infective native and prosthetic valve endocarditis (INVE, IPVE).

Method: Analysis of 413 patients (171 with IPVE vs. Read More

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New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis.

J Clin Med 2021 Apr 17;10(8). Epub 2021 Apr 17.

Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.

Infective endocarditis, osteomyelitis, and osteosynthesis-associated infections are mostly caused by Gram-positive bacteria. They are often difficult to treat and are associated with a poor prognosis. In the past 20 years, nine antibiotic drugs with predominant activity against Gram-positive bacteria have been introduced and approved by the Food and Drug Administration or the European Medicines Agency: ceftaroline, daptomycin, telavancin, dalbavancin, oritavancin, linezolid, tedizolid, delafloxacin, and omadacycline. Read More

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What Is in a Cat Scratch? Growth of in a Biofilm.

Microorganisms 2021 Apr 14;9(4). Epub 2021 Apr 14.

Department of Molecular Medicine, MDC7, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA.

() is a gram-negative bacterium that causes cat scratch disease, bacteremia, and endocarditis, as well as other clinical presentations. has been shown to form a biofilm in vitro that likely plays a role in the establishment and persistence of the bacterium in the host. Biofilms are also known to form in the cat flea vector; hence, the ability of this bacterium to form a biofilm has broad biological significance. Read More

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Advantages of 18F-FDG PET/CT Imaging over Modified Duke Criteria and Clinical Presumption in Patients with Challenging Suspicion of Infective Endocarditis.

Diagnostics (Basel) 2021 Apr 18;11(4). Epub 2021 Apr 18.

Nuclear Medicine and Molecular Imaging, ICANS, University Hospitals of Strasbourg, rue Albert Calmette, 67093 Strasbourg, France.

According to European Society of Cardiology guidelines (ESC2015) for infective endocarditis (IE) management, modified Duke criteria (mDC) are implemented with a degree of clinical suspicion degree, leading to grades such as "possible" or "rejected" IE despite a persisting high level of clinical suspicion. Herein, we evaluate the F-FDG PET/CT diagnostic and therapeutic impact in IE suspicion, with emphasis on possible/rejected IE with a high clinical suspicion. Excluding cases of definite IE diagnosis, 53 patients who underwent F-FDG PET/CT for IE suspicion were selected and afterwards classified according to both mDC (possible IE/Duke 1, rejected IE/Duke 0) and clinical suspicion degree (high and low IE suspicion). Read More

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Mechanistic Fingerprinting Reveals Kinetic Signatures of Resistance to Daptomycin and Host Defense Peptides in .

Antibiotics (Basel) 2021 Apr 8;10(4). Epub 2021 Apr 8.

Division of Infectious Diseases, Department of Medicine, Los Angeles County Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

infections are increasingly prevalent in specific populations, including neutropenic cancer and endocarditis patients. strains have a propensity to evolve rapid, high-level and durable resistance to daptomycin (DAP-R) in vitro and in vivo, although the mechanism(s) involved remain incompletely defined. We examined mechanisms of DAP-R versus cross-resistance to cationic host defense peptides (HDPs), using an isogenic strain-pair: (i) DAP-susceptible (DAP-S) parental 351-WT (DAP MIC = 0. Read More

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Impact of immunosuppressive agents on clinical manifestations and outcome of Staphylococcus aureus bloodstream infection - A propensity score matched analysis in two large, prospectively evaluated cohorts.

Clin Infect Dis 2021 Apr 29. Epub 2021 Apr 29.

Division of Infectious Diseases, Department of Medicine II, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: Staphylococcus aureus bloodstream infection (SAB) is a common, life-threatening infection. The impact of immunosuppressive agents on the outcome of patients with SAB is incompletely understood.

Methods: Data from two large prospective, international, multicenter cohort studies (INSTINCT and ISAC) between 2006 and 2015 were analyzed. Read More

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Microdiversity of isolates in cases of Infective Endocarditis: selection of non-synonymous mutations and large deletions is associated with phenotypic modifications.

Emerg Microbes Infect 2021 Apr 29:1-181. Epub 2021 Apr 29.

Department of Microbiology, Henri Mondor Hospital, AP-HP, Université Paris-Est, Créteil, France.

Context: Today, infective endocarditis (IE) caused by represents 10% of all IE and is marked by its difficult management and the frequency of relapses. Although the precise reasons for that remain to be elucidated, the evolution of the culprit strain under selective pressure through microdiversification could be, at least in part, involved.

Material And Methods: To further study the genetic microdiversity and its possible phenotypic manifestations in IE, we sequenced and compared multiple isolates from the valves, blood culture and joint fluid of five patients who underwent valvular surgery. Read More

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Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study.

Int J Health Serv 2021 Apr 29:207314211012357. Epub 2021 Apr 29.

Clinic University Hospital of Valladolid, Valladolid, Spain.

Economic recession has dire consequences on overall health. None have explored the impact of economic crisis (EC) on infective endocarditis (IE) mortality. We conducted a retrospective, nationwide, temporal trend study analyzing mortality trends by age, sex, and adverse outcomes in patients diagnosed with IE in Spain from 1997 to 2014. Read More

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Infective endocarditis caused by of a native mitral valve.

IDCases 2021 12;24:e01119. Epub 2021 Apr 12.

Epidemiology and Bacterial Resistance Research Team/BIO-INOVA Centre, Faculty of Medicine and Pharmacy (University Mohammed V), Rabat, Morocco.

is a rare cause of infectious endocarditis. We report a clinical case of endocarditis of a native mitral valve in a young 26-year-old woman with a recurrent urinary tract infection who had a high fever for one week despite probabilistic treatment with amoxcillin-clavulanic acid 3 g per day. The patient was successfully treated with antibiotics and recovered without surgery. Read More

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Pregnancy outcomes in women with a systemic right ventricle and transposition of the great arteries results from the ESC-EORP Registry of Pregnancy and Cardiac disease (ROPAC).

Heart 2021 Apr 28. Epub 2021 Apr 28.

Department of Cardiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

Objective: Cardiac disease is a major cause of maternal mortality. Data regarding pregnancy outcomes in women with a systemic right ventricle (sRV) are scarce. We studied pregnancy outcomes in women with an sRV after the atrial switch procedure for transposition of the great arteries (TGA) or congenitally corrected TGA (CCTGA). Read More

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Determination of MIC Quality Control Parameters for Exebacase, a Novel Lysin with Anti-staphylococcal Activity.

J Clin Microbiol 2021 Apr 28. Epub 2021 Apr 28.

ContraFect Corporation, Yonkers, New York

Exebacase (CF-301), a novel, anti-staphylococcal lysin (cell-wall hydrolase) is the first agent of this class to enter late-stage clinical development (Phase 3, NCT04160468) for the treatment of bacteremia including right-sided endocarditis. A multi-laboratory Clinical and Laboratory Standards Institute (CLSI) M23-defined tier 2 quality control (QC) study was conducted to establish exebacase QC ranges for a new reference broth microdilution method. ATCC 29213 and ATCC 29212 were selected as reference QC strains. Read More

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Mid-term Results of Isolated Tricuspid Valve Replacement - Implications for Clinical Decision Making.

Ann Thorac Surg 2021 Apr 25. Epub 2021 Apr 25.

Department of Cardiothoracic surgery, Carmel Medical Center, Haifa, Israel.

Background: Isolated tricuspid valve replacement (TVR) is considered high risk surgery. We investigated our outcomes of TVR with the aim of identifying variables that may influence morbidity and mortality of isolated TVR compared to combined TVR and left sided valve surgery.

Methods: Retrospective analysis of patients undergoing TVR surgery. Read More

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Outcomes of Aortic Valve Replacement for Chronic Aortic Insufficiency: Analysis of the STS Database.

Ann Thorac Surg 2021 Apr 25. Epub 2021 Apr 25.

Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX. Electronic address:

Background: Outcomes and risk factors for surgical aortic valve replacement (SAVR) for aortic insufficiency (AI) have not been evaluated in a national cohort. We analyze the incidence, outcomes, and risk factors for SAVR for AI in the Society of Thoracic Surgeons Adult Cardiac Surgery Database.

Methods: The national database was queried for patients with moderate or greater AI undergoing isolated SAVR between July 2011 and December 2018. Read More

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Peritoneovenous Shunt for Intractable Ascites in Children. A Series of 4 Cases.

J Pediatr Gastroenterol Nutr 2021 Mar 15. Epub 2021 Mar 15.

*INSERM (National Institute of Health and Medical Research) U1016, Université Paris-Descartes, Institut Cochin, Paris, France †Pediatric Surgery Unit, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, France. ‡Pediatric Gastroenterology-Hepatology-Nutrition Unit, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, France. §Pediatric Intensive Care Unit, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, France. ||Department of Pediatric Surgery, Hôpital Universitaire de Tours, Tours, France ¶Université Paris Descartes, 75015 Paris, France.

Intractable ascites is a rare condition in children mainly caused by cirrhosis or lymphatic disorders. Internal drainage may be considered as rescue therapy. In our department, 4 patients aged from 2 months to 15 years old underwent a peritoneovenous shunt (PVS) placement between 2010 and 2020. Read More

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Preoperative stroke before cardiac surgery does not increase risk of postoperative stroke.

Sci Rep 2021 Apr 27;11(1):9025. Epub 2021 Apr 27.

Division of Cardiothoracic Surgery, Indiana University School of Medicine, Indiana University Health Methodist Hospital, 1801 N. Senate Blvd., Suite 3300, Indianapolis, IN, 46202, USA.

The optimal time when surgery can be safely performed after stroke is unknown. The purpose of this study was to investigate how cardiac surgery timing after stroke impacts postoperative outcomes between 2011-2017 were reviewed. Variables were extracted from the institutional Society of Thoracic Surgeons database, statewide patient registry, and medical records. Read More

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Aorto-left atrial fistula secondary to infective aortic endocarditis and endarteritis in a cat with valvular aortic stenosis.

J Vet Cardiol 2021 Mar 29;35:101-107. Epub 2021 Mar 29.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California - Davis, One Garrod Drive, Davis, CA 95616, USA.

A cat previously diagnosed with valvular aortic stenosis developed acute respiratory distress. A new continuous heart murmur was noted on physical exam. Echocardiographic examination revealed vegetative lesions on the aortic valve and continuously shunting blood flow from the aorta into the left atrium. Read More

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Infective endocarditis in pregnancy from 2009 to 2019: the consequences of injection drug use.

Infect Dis (Lond) 2021 Apr 27:1-7. Epub 2021 Apr 27.

Gill Heart and Vascular Institute, Division of Cardiovascular Medicine, University of Kentucky, Lexington, KY, USA.

Background: Endocarditis during pregnancy carries a maternal mortality of up to 30%, but prior publications do not reflect the current opioid epidemic.

Case Presentations: We reviewed our institution's infective endocarditis registry from 2009 to 2019 and identified 19 females with endocarditis during pregnancy in order to compare our contemporary outcomes with historical reports. In our cohort, intravenous drug use was reported in all cases, and the most common pathogen was (74%) followed by (13%). Read More

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Comparative one-year outcomes of invasive Staphylococcus aureus infections among persons with and without drug use: an observational cohort study.

Clin Infect Dis 2021 Apr 27. Epub 2021 Apr 27.

University of California San Francisco, San Francisco, CA, USA.

Background: Persons who use drugs (PWUD) face substantial risk of Staphylococcus aureus infections. Limited data exist describing clinical and substance use characteristics of PWUD with invasive S. aureus infections or comparing treatment and mortality outcomes in PWUD vs. Read More

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