39,977 results match your criteria Endocarditis


Multisite embolic events secondary to pulmonary valve endocarditis.

Eur Heart J Cardiovasc Imaging 2020 May 28. Epub 2020 May 28.

Cardiology Department, Centro Hospitalar Universitário Lisboa Norte (CHULN), Lisbon Academic Medical Centre and Cardiovascular Centre, Faculty of Medicine, University of Lisbon, Hospital de Santa Maria. Av. Prof. Egas Moniz MB, 1649-028 Lisboa, Portugal.

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http://dx.doi.org/10.1093/ehjci/jeaa132DOI Listing

Analysis of a 10-year period of lead removal in a referral centre.

Interact Cardiovasc Thorac Surg 2020 May 28. Epub 2020 May 28.

Cardiology Department, Centro Hospitalar de Lisboa Ocidental-Hospital de Santa Cruz, Lisboa, Portugal.

Objectives: Our goal was to analyse all lead extraction procedures (transvenous or open surgery) performed in our centre and the short- and long-term follow-up data from these patients.

Methods: All lead extractions performed from 2008 to 2017 were retrospectively reviewed for patient characteristics and indications for device implantation; indications for lead extraction; techniques used; peri- and postprocedural complications and short- and long-term follow-up data.

Results: A total of 159 patients (282 leads) were included [age 70 (62-78) years; 72% men]. Read More

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http://dx.doi.org/10.1093/icvts/ivaa078DOI Listing

Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort.

Open Forum Infect Dis 2020 May 10;7(5):ofaa120. Epub 2020 Apr 10.

American University of Beirut Medical Center, Beirut, Lebanon.

Background: Beta-hemolytic streptococci (BHS) are an uncommon cause of infective endocarditis (IE). The aim of this study was to describe the clinical features and outcomes of patients with BHS IE in a large multinational cohort and compare them with patients with viridans streptococcal IE.

Methods: The International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) is a large multinational database that recruited patients with IE prospectively using a standardized data set. Read More

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http://dx.doi.org/10.1093/ofid/ofaa120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240340PMC

Axillary Approach for Venoarterial Extracorporeal Membrane Oxygenation Cannulation.

Cureus 2020 Apr 22;12(4):e7788. Epub 2020 Apr 22.

Cardiology/Internal Medicine, University of Maryland, Baltimore, USA.

Extracorporeal membrane oxygenation support (ECMO) is a form of mechanical circulatory support that is used in patients with severe dysfunction of heart or lung or both. Depending on whether it is venovenous or venoarterial support, it can temporarily substitute for circulation and ventilation while the underlying cause is addressed. Traditional approach for cannulation usually involves the femoral vessels. Read More

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http://dx.doi.org/10.7759/cureus.7788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243636PMC

Cryptococcus meningitis mimicking cerebral septic emboli, a case report series demonstrating injection drug use as a risk factor for development of disseminated disease.

BMC Infect Dis 2020 May 27;20(1):381. Epub 2020 May 27.

Atrium Health Department of Medicine, Charlotte, NC, USA.

Background: Clinicians may be less inclined to consider a diagnosis of cryptococcal meningitis in people without HIV infection or transplant-related immunosuppression. This may lead to a delay in diagnosis particularly if disseminated cryptococcal disease mimics cerebral septic emboli in injection drug use (IDU) leading to a search for endocarditis or other infectious sources. Though, IDU has been described as a potential risk for disseminated cryptococcal disease. Read More

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http://dx.doi.org/10.1186/s12879-020-05108-1DOI Listing

Relapsing polychondritis, a rare cause of valvulopathy: a review of the medical literature.

Arch Cardiol Mex 2020 ;90(2):189-192

Departamento de Cardiología Clínica. Instituto Nacional de Cardiología "Ignacio Chávez", Ciudad de México, México.

Relapsing polychondritis is an inflammatory disease that involves cartilaginous structures predominantly in the nose, ears and respiratory tract. Cardiovascular involvement is not common. Despite this, they are the second cause of death in patients with relapsing polychondritis. Read More

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http://dx.doi.org/10.24875/ACM.19000245DOI Listing
January 2020

Echocardiographic and Clinical Follow-up After Aortic Valve Neocuspidization Using Autologous Pericardium.

World J Surg 2020 May 26. Epub 2020 May 26.

Department of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, CH-4031, Basel, Switzerland.

Introduction: Mid-term data from a single centre showed the safety and durability of aortic valve neocuspidization using autologous pericardium (OZAKI procedure). Since validation data from other centres are missing, aim of this study was to analyze echocardiographic and clinical results of our first patients that were operated with the OZAKI technique.

Methods: Thirty-five patients (24 males, median (IQR) age 72. Read More

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http://dx.doi.org/10.1007/s00268-020-05588-xDOI Listing

Complete genome sequence of a methicillin-resistant Staphylococcus lugdunensis strain and characteristics of its staphylococcal cassette chromosome mec.

Sci Rep 2020 May 26;10(1):8682. Epub 2020 May 26.

Center of Excellence for Infection Control Science, Graduate School of Medicine, Juntendo University, Tokyo, Japan.

Symptoms of Staphylococcus lugdunensis infection are often similar to those of Staphylococcus aureus infection, including skin and soft-tissue lesions, bacteremia and infective endocarditis. Despite the severity of these infections, S. lugdunensis is regarded as a less important pathogen than drug-resistant S. Read More

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http://dx.doi.org/10.1038/s41598-020-65632-7DOI Listing

When Zoonotic Organisms Cross Over-Trueperella pyogenes Endocarditis Presenting as a Septic Embolic Stroke.

Cureus 2020 Apr 20;12(4):e7740. Epub 2020 Apr 20.

Internal Medicine, Hurley Medical Center, Michigan State University, Flint, USA.

Infective endocarditis (IE) remains a significant cause of morbidity and mortality worldwide, with numerous pathogens as culprits. We present a case of IE that evolved to a septic embolic stroke caused by an extremely rare bacteria Trueperella (T.) pyogenes that primarily infects non-humans. Read More

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http://dx.doi.org/10.7759/cureus.7740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241225PMC

Molecular Imaging of Infective Endocarditis With 6''-[F]Fluoromaltotriose Positron Emission Tomography-Computed Tomography.

Circulation 2020 May 26;141(21):1729-1731. Epub 2020 May 26.

Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Bio-X Program (M.W., G.G., E.C., M.N., T.H., M.T.G., J.C.W., S.S.G.), Stanford University School of Medicine, CA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.043924DOI Listing

The Opioid Crisis and the Inpatient Floor: Considering Injection Drug Use in the Management of Infective Endocarditis and Acute Pain.

Harv Rev Psychiatry 2020 May 20. Epub 2020 May 20.

From Harvard Medical School (Ms. Mitchell and Drs. Montgomery and Suzuki); Ethics Service and Center for Nursing Excellence (Dr. Millikin), Division of Infectious Diseases (Dr. Montgomery), and Department of Psychiatry (Dr. Suzuki), Brigham and Women's Hospital, Boston, MA; Division of Cardiac Surgery, University of Toronto, Trillium Health Partners, Toronto, Canada (Dr. Singh).

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http://dx.doi.org/10.1097/HRP.0000000000000259DOI Listing

Predictors of in-hospital mortality in patients with infective endocarditis.

Acta Cardiol 2020 May 26:1-8. Epub 2020 May 26.

Division of Cardiology, Department of Medicine II, Kansai Medical University, Osaka, Japan.

Infective endocarditis is a serious septic disease, and the epidemiological profile has changed over the last decade. However, there is a paucity of data regarding the current outcome and predictor of in-hospital mortality in patients with infective endocarditis. Consecutive patients diagnosed as infective endocarditis based on the modified Duke criteria at Kansai Medical University hospital from January 2006 to June 2019 were prospectively included. Read More

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http://dx.doi.org/10.1080/00015385.2020.1767368DOI Listing

Q fever endocarditis.

Acta Cardiol 2020 May 26:1-2. Epub 2020 May 26.

Department of Cardiovascular Disease, CHU UCL Namur, Université Catholique de Louvain, Yvoir, Belgium.

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http://dx.doi.org/10.1080/00015385.2020.1762028DOI Listing

Ultrasound guided venipuncture for implantation of cardiac implantable electronic devices. A single-center, retrospective study.

Pacing Clin Electrophysiol 2020 May 25. Epub 2020 May 25.

Department of Surgery, Catholic University Hospital " A. Gemelli", Roma, Italy.

Background: The venous access for the insertion of permanent leads of cardiac implantable electronic devices (CIEDs) is often achieved by venous cutdown of the cephalic vein, or by 'blind' puncture of the subclavian vein using anatomical landmarks, or by fluoroscopy-assisted methods.

Methods: We have retrospectively analyzed our clinical experience so to verify the feasibility, the safety and efficacy of the adoption of ultrasound guided puncture/cannulation of the axillary vein for this purpose.

Results: 987 leads were placed during 548 consecutive procedures, accessing the axillary vein in the infra-clavicular area using real-time ultrasound guidance. Read More

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http://dx.doi.org/10.1111/pace.13961DOI Listing

Aortic annular enlargement techniques using an original patch for prosthetic valve endocarditis.

BMC Cardiovasc Disord 2020 May 25;20(1):246. Epub 2020 May 25.

Department of Cardiovascular Surgery, Hitachi General Hospital, 2-1-1 Jonan, Hitachi, Ibaraki, 317-0077, Japan.

Background: Prosthetic valve endocarditis (PVE) is a serious complication, and it is difficult to treat marked adhesion and infectious tissue.

Case Presentation: There were four patients with aortic PVE, whose ages ranged from 59 to 80 years. In all patients, transoesophageal echocardiography revealed periannular abscess formation. Read More

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http://dx.doi.org/10.1186/s12872-020-01518-wDOI Listing

Added value of three-dimensional transesophageal echocardiography in management of mitral paravalvular leaks.

Echocardiography 2020 May 25. Epub 2020 May 25.

CardioVascular Imaging/Cardiology Department, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Prosthetic paravalvular leak (PVL) is a well-known serious complication following surgically as well as percutaneously implanted prosthetic valves. It usually happens due to incomplete sealing of the prosthetic ring to the native cardiac tissue whether immediately postoperative or considerably later as a complication of infective endocarditis, etc Surgery has been always the treatment of choice for clinically significant PVLs. However, percutaneous transcatheter closure therapy has become a successful alternative in carefully selected group of patients. Read More

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http://dx.doi.org/10.1111/echo.14708DOI Listing

Bartonella endocarditis mimics the clinical and immunologic findings of autoimmune lymphoproliferative syndrome.

Pediatr Blood Cancer 2020 May 25:e28325. Epub 2020 May 25.

Division of Pediatric Infectious Diseases, Monroe Carell Junior Children's Hospital at Vanderbilt, Nashville, Tennessee.

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http://dx.doi.org/10.1002/pbc.28325DOI Listing

Comparison of infective endocarditis risk between balloon and self-expandable valves following transcatheter aortic valve replacement: systematic review and meta-analysis.

Cardiovasc Interv Ther 2020 May 24. Epub 2020 May 24.

Department of Cardiology, University of California Riverside, Riverside, CA, USA.

This study aimed to compare incidence of IE between BE and SE valves by performing a systematic review and meta-analysis of the literature. We comprehensively searched the databases of MEDLINE and EMBASE from inception to November 2019. Included studies were published observational studies that compared the risk of IE among patients undergoing TAVR employing BE versus SE valves, using the random-effects to calculate risk ratios and 95% confidence intervals (CIs). Read More

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http://dx.doi.org/10.1007/s12928-020-00675-1DOI Listing

Antimicrobial effects of mustard oil-containing plants against oral pathogens: an in vitro study.

BMC Complement Med Ther 2020 May 24;20(1):156. Epub 2020 May 24.

Center for Infectious Diseases, Heidelberg University Hospital, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany.

Background: The present study examines the antimicrobial activity of nasturtium herb (Tropaeoli maji herba) and horseradish root (Armoraciae rusticanae radix) against clinically important oral bacterial pathogens involved in periodontitis, gingivitis, pulpitis, implantitis and other infectious diseases.

Methods: A total of 15 oral pathogens, including members of the genera Campylobacter, Fusobacterium, Prevotella, Parvimonas, Porphyromonas, Tanerella, Veillonella, and HACEK organisms, were exposed to [1] a combination of herbal nasturtium and horseradish using a standardized gas test and [2] a mixture of synthetic Isothiocyantes (ITCs) using an agardilution test. Headspace gas chromatography mass spectrometry was employed to quantify the amount of allyl-, benzyl-, and 2- phenyl- ethyl-ITC. Read More

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http://dx.doi.org/10.1186/s12906-020-02953-0DOI Listing

Diagnosis and treatment of infective endocarditis in pregnancy: a case report.

J Cardiothorac Surg 2020 May 24;15(1):109. Epub 2020 May 24.

Department of Ultrasound, Zhejiang Provincial People's Hospital, People's Hospital of HangZhou Medical College, Hangzhou, 310014, Zhejiang, China.

Background: Pregnancy with infective endocarditis (IE) is rare, but the fetal and maternal mortality rates of these pregnancies are very high, making IE a serious threat to the safety of pregnant women and their fetuses. Therefore, for pregnant women with recurrent fever, a detailed medical history and physical examination should be performed, echocardiography and blood culture should be carried out as soon as possible, multidisciplinary consultation should be implemented, and a diagnosis and treatment plan should be formulated right away, as this is key to saving the lives of mothers and infants.

Case Introduction: A 30-year-old pregnant Chinese woman had IE at 26 weeks of gestation. Read More

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http://dx.doi.org/10.1186/s13019-020-01147-6DOI Listing

Vertebral osteomyelitis: Clinical, microbiological and radiological characteristics of 116 patients.

Med Clin (Barc) 2020 May 20. Epub 2020 May 20.

Rheumatology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.

Introduction/objectives: To describe the clinical, radiological and microbiological characteristics of vertebral osteomyelitis patients, analysing the factors that played a role on their outcome.

Patients And Methods: Single-centre retrospective observational study including patients diagnosed with vertebral osteomyelitis, based on the combination of clinical presentation with either a definitive bacteriological diagnosis and/or imaging studies.

Results: 116 adult patients were included with a mean age of 62. Read More

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http://dx.doi.org/10.1016/j.medcli.2019.12.029DOI Listing

Surgical valve repair of native pulmonary valve endocarditis using Ozaki technique.

Ann Thorac Surg 2020 May 20. Epub 2020 May 20.

Department of Anaesthesia and Critical Care, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Surgery for infective endocarditis in the pulmonary position is an effective method of treatment despite a very uncommon pathology and few operations being performed. We present an adult male with right sided infective endocarditis where pulmonary valve cusps were almost completely damaged. Pulmonary valve was successfully reconstructed using glutaraldehyde treated autologous pericardium by Ozaki technique. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.03.125DOI Listing

Mid- to long-term clinical and echocardiographic outcomes after transcatheter aortic valve replacement with a new-generation, self-expandable system.

Catheter Cardiovasc Interv 2020 May 23. Epub 2020 May 23.

Invasive Cardiology section, Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil.

Objectives: The aim of the study was to evaluate mid- to late clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) with Acurate neo™ (Boston Scientific, Boston, MA).

Background: TAVR is an established treatment for aortic stenosis (AS). Few data exist on mid- to long-term outcomes and durability after new-generation valves. Read More

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http://dx.doi.org/10.1002/ccd.28999DOI Listing

Prosthetic aortic valve endocarditis complicated by COVID-19 and hemorrhage.

J Card Surg 2020 May 22. Epub 2020 May 22.

Department of Cardiac Surgery, St. Bartholomew's Hospital, London, UK.

The novel coronavirus, now termed SARS-CoV-2, has caused a significant global impact in the space of 4 months. Almost all elective cardiac surgical operations have been postponed with only urgent and emergency operations being considered in order to maximise resource utilisation. We present a case of a 69-year old lady with an infected prosthetic aortic valve for consideration of urgent inpatient surgery. Read More

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http://dx.doi.org/10.1111/jocs.14643DOI Listing

Bacterial biofilms in infective endocarditis: an in vitro model to investigate emerging technologies of antimicrobial cardiovascular device coatings.

Clin Res Cardiol 2020 May 22. Epub 2020 May 22.

Biofilmcenter, Department of Microbiology, Infectious Diseases and Immunology, Charité, Universitaetsmedizin Berlin, Berlin, Germany.

Objective: In spite of the progress in antimicrobial and surgical therapy, infective endocarditis (IE) is still associated with a high morbidity and mortality. IE is characterized by bacterial biofilms of the endocardium, especially of the aortic and mitral valve leading to their destruction. About one quarter of patients with formal surgery indication cannot undergo surgery. Read More

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http://dx.doi.org/10.1007/s00392-020-01669-yDOI Listing

SpoVG modulates cell aggregation by regulating expression and eDNA release in .

Appl Environ Microbiol 2020 May 22. Epub 2020 May 22.

Department of Oncology, The First Affiliated Hospital, University of Science and Technology of China. Hefei, Anhui 230027, China

Biofilm formation is involved in numerous infections such as endocarditis, septic arthritis, osteomyelitis, and infections on in-dwelling medical devices. In these diseases, forms biofilms as cell aggregates interspersed in host matrix material. Here, we have observed that cell aggregation was significantly higher in the isogenic -deletion strain compared with that of the wild-type strain. Read More

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http://dx.doi.org/10.1128/AEM.00591-20DOI Listing

Paediatric aortic valve replacement using decellularized allografts.

Eur J Cardiothorac Surg 2020 May 22. Epub 2020 May 22.

Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany.

Objectives: Options for paediatric aortic valve replacement (AVR) are limited if valve repair is not feasible. Results of paediatric Ross procedures are inferior to adult Ross results, and mechanical AVR imposes constant anticoagulation with the inherent risks.

Methods: The study design was a prospective, multicentre follow-up of all paediatric patients receiving decellularized aortic homografts (DAHs) for AVR in 8 European centres. Read More

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http://dx.doi.org/10.1093/ejcts/ezaa119DOI Listing

Endocarditis: As Challenging as Ever.

Trends Cardiovasc Med 2020 May 19. Epub 2020 May 19.

Hackensack University Medical Center, Camden, UNITED STATES. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2020.05.003DOI Listing

Is aortic valve replacement with a minimally invasive extracorporeal circuit a contemporary option for octogenarians?

Interact Cardiovasc Thorac Surg 2020 May 23. Epub 2020 May 23.

Department of Thoracic and Cardiovascular Surgery, Braunschweig Clinic, Braunschweig, Germany.

Objectives: Minimally invasive extracorporeal circuits have been introduced to cardiac surgery in an attempt to reduce the negative effects of cardiopulmonary bypass on patient outcome. On the other hand, transcatheter aortic valve replacement (TAVR) provides an excellent option to replace the aortic valve without the need for cardiopulmonary bypass. Several studies have compared TAVR to surgical aortic valve replacement (SAVR) but none have utilized a minimally invasive extracorporeal circuit. Read More

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http://dx.doi.org/10.1093/icvts/ivaa066DOI Listing

Diagnostic imaging in infective endocarditis: a contemporary perspective.

Expert Rev Anti Infect Ther 2020 May 22. Epub 2020 May 22.

Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine and Science , Rochester, MN, USA.

Introduction: Infective endocarditis (IE) remains a diagnostic challenge. Prompt diagnosis is essential for accurate risk stratification and appropriate therapeutic decisions and surgical management. In recent years, use of multimodal imaging has had a transformative effect on the diagnostic approach of IE in selected patients. Read More

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http://dx.doi.org/10.1080/14787210.2020.1773260DOI Listing

Impact of recent heart failure hospitalization on clinical outcomes in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement: an analysis from the PARTNER 2 trial and registries.

Eur J Heart Fail 2020 May 22. Epub 2020 May 22.

Cardiovascular Research Foundation, New York, NY, USA.

Aims: Heart failure (HF) hospitalization prior to transcatheter aortic valve replacement (TAVR) is associated with increased post-procedural mortality. We sought to assess the association between recent (≤6 months) HF hospitalization and long-term adverse outcomes in patients with symptomatic, severe aortic stenosis, undergoing TAVR in the PARTNER 2 trial and registries.

Methods And Results: Intermediate to high or even prohibitive risk patients who underwent TAVR in the PARTNER 2 trial and registries were included in the analysis. Read More

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http://dx.doi.org/10.1002/ejhf.1841DOI Listing

Unique characterization of complex endocarditic vegetations using 3D TOE.

Echo Res Pract 2020 May 1. Epub 2020 May 1.

J Khan, Cardiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom of Great Britain and Northern Ireland.

A 31-year old male was admitted with suspected infective endocarditis given intravenous drug use, lung and cerebral abscesses and Staphyloccus aureus bacteraemia. TTE imaging was limited given supine positioning and mechanical ventilation but suggested a posterior mitral valve leaflet (PMVL) mass. Three-dimensional TOE provided uniquely detailed assessment of two complex infective masses. Read More

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http://dx.doi.org/10.1530/ERP-19-0062DOI Listing

Aortic Valve Repair for Aortic Insufficiency or Dilatation: Technical Evolution and Long-term Outcomes.

Ann Thorac Surg 2020 May 8. Epub 2020 May 8.

Department of Thoracic- and Cardiovascular Surgery, Siegburg Heart Center, Germany. Electronic address:

Background: Aortic valve repair is an attractive alternative to valve replacement for the treatment of aortic valve insufficiency. Hereby, we report on the mid-term outcomes after aortic valve repair for aortic valve insufficiency with emphasis on durability of repair.

Methods: Between 1996 and 2017, 560 consecutive patients (mean age 56 ± 16 years) underwent various aortic valve repair procedures on tricuspid (n=415, 74%) and bicuspid aortic valve (n=145, 26%). Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.03.105DOI Listing

Aerococcus Urinae Aortic Valve Endocarditis with Kissing Aortic Wall Ulcer: A Case Report and Literature Review.

Am J Case Rep 2020 May 21;21:e920974. Epub 2020 May 21.

Department of Internal Medicine, Northwestern McHenry Hospital, McHenry, IL, USA.

BACKGROUND Initially presumed as nonpathogenic, the bacterial genus aerococcus now includes 7 distinct virulent and avirulent species. Aerococcus urinae first isolated in 1992 is an uncommon cause of urinary tract infection (UTI) and is seen in only 0.15% to 0. Read More

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http://dx.doi.org/10.12659/AJCR.920974DOI Listing

Isolated bicuspid aortic valve repair with double annuloplasty: The French approach.

Multimed Man Cardiothorac Surg 2020 May 11;2020. Epub 2020 May 11.

Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.

Isolated aortic valve repair is an alternative to aortic valve replacement in patients with severe aortic regurgitation. It reduces the risk of prosthesis-related complications, such as thromboembolism and endocarditis, and there is no need for long-term oral anticoagulation. However, repair techniques are technically demanding, especially in bicuspid aortic valves. Read More

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http://dx.doi.org/10.1510/mmcts.2020.016DOI Listing

Contemporary Management Strategies in VAD Infection.

Curr Heart Fail Rep 2020 May 20. Epub 2020 May 20.

Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.

Purpose Of Review: The use of durable ventricular assist devices (VAD) to manage end-stage heart failure is increasing, but infection remains a leading cause of morbidity and mortality among patients with VAD. In this review, we synthesize recent data pertaining to the epidemiology, diagnosis, management, and prevention of VAD infections, discuss transplant considerations in patients with VAD infections, and highlight remaining knowledge gaps. We also present a conceptual framework for treating clinicians to approach these infections that draws on the same principles that guide the treatment of analogous infections that occur in patients without VAD. Read More

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http://dx.doi.org/10.1007/s11897-020-00459-xDOI Listing

Colonic mucormycosis in an immunocompetent patient with endocarditis.

IDCases 2020 11;20:e00773. Epub 2020 May 11.

University of Arkansas for Medical Sciences, Fayetteville, AR, United States.

Mucormycosis is a fatal opportunistic fungal infection. Rarely it can occur in immunocompetent patients. Here, we present a case of colonic mucormycosis in immunocompetent patients. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229287PMC

Chronic thromboembolic pulmonary hypertension secondary to implantable cardioverter defibrillator lead thrombus in a patient with Brugada syndrome: a rare complication requiring a multidisciplinary approach.

BMJ Case Rep 2020 May 19;13(5). Epub 2020 May 19.

Pulmonary Hypertension Unit, Department of Cardiology, Hospital Garcia de Orta, Almada, Portugal.

We report the case of a 57-year-old male patient with prior syncope associated with sustained ventricular tachycardia in the setting of Brugada syndrome, who was submitted to implantation of a cardioverter defibrillator for secondary prevention. During follow-up, he presented a significant increase in lead impedance, and a transthoracic echocardiogram showed a mass attached to the lead. He was started on oral anticoagulation after infective endocarditis was excluded but nevertheless suffered repeated episodes of pulmonary embolism that led to severe chronic thromboembolic pulmonary hypertension. Read More

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http://dx.doi.org/10.1136/bcr-2020-234549DOI Listing

Fibrinolysis and the Influence of Tranexamic Acid Dosing in Cardiac Surgery.

J Cardiothorac Vasc Anesth 2020 May 5. Epub 2020 May 5.

Department of Transfusion Medicine and Clinical Hemostaseology, Düsseldorf University Hospital, Düsseldorf, Germany.

Objective: The present study aimed to determine whether underlying disease, performed surgery, and dose of tranexamic acid influence fibrinolysis measured with D-dimer levels.

Design: Retrospective analysis.

Setting: Single institution (Department of Cardiac Surgery and Section of Clinical Hemostaseology at the Düsseldorf University Hospital). Read More

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http://dx.doi.org/10.1053/j.jvca.2020.03.040DOI Listing

Mitral Valve Aneurysm in Mitral Valve Endocarditis:A Case Report.

Am J Med Case Rep 2020 19;8(3):83-87. Epub 2020 Jan 19.

Division of Cardiovascular Diseases and Department of Internal Medicine, State University of New York, Downstate Medical Center, Health Sciences University, Brooklyn NY 11203, USA.

Mitral valve aneurysm (MVA) is an ominous complication of infective endocarditis (IE), with worse outcomes seen among patients with preexisting valvular disease or intravenous drug use. Valve aneurysms can perforate or lead to rupture of the chordae tendineae, with the consequent development of severe mitral regurgitation and acute pulmonary edema. We present a case of a 54-year-old woman with hypertension, obesity, diabetes mellitus, hyperlipidemia, chronic obstructive pulmonary disease, peptic ulcer disease, obstructive sleep apnea, gastroesophageal reflux disease, intravenous drug abuse and bipolar disorder who developed MVA one month after being discharged for IE. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237018PMC
January 2020

In-Silico Proteomic Exploratory Quest: Crafting T-Cell Epitope Vaccine Against Whipple's Disease.

Int J Pept Res Ther 2020 May 18:1-11. Epub 2020 May 18.

Domain of Bioinformatics, School of Bio-Engineering and Bio-Sciences, Lovely Professional University, Punjab, India.

Whipple's disease is one of the rare maladies in terms of spread but very fatal one as it is linked with many disorders (like Gastroenteritis, Endocarditis etc.). Also, current regimens include less effective drugs which require long duration follows up. Read More

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http://dx.doi.org/10.1007/s10989-020-10077-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233679PMC

"Holes-in-one": A case of concurrent windsock mitral valve, root abscess, and Gerbode defect.

Echocardiography 2020 May 19. Epub 2020 May 19.

Section of Cardiovascular Imaging, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.

Infective endocarditis is a heterogeneous disease with a wide array of pathological lesions. We present a 55-year-old man with severe mitral and aortic regurgitation on transthoracic echocardiography. Transesophageal echocardiogram characterized the mechanisms detecting a windsock mitral valve perforation, aortic root abscess, and Gerbode ventricular septal defect, with the deep transgastric view showing all three pathologies concurrently. Read More

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http://dx.doi.org/10.1111/echo.14703DOI Listing

A Case Report of Acute Heart Failure Due to Infective Aortic Endocarditis Diagnosed by Point-of-care Ultrasound.

Clin Pract Cases Emerg Med 2020 May 27;4(2):193-196. Epub 2020 Apr 27.

University of Kansas Health System, Department of Emergency Medicine, Kansas City, Kansas.

Introduction: Infective endocarditis (IE) is a life-threatening condition with significant morbidity and mortality, and can require surgical repair.

Case Report: A 36-year-old man presented to the emergency department for worsening dyspnea and chest pain. Point-of-care echocardiography demonstrated a mobile oscillating mass on the aortic valve with poor approximation of the valve leaflets, suggesting aortic valve insufficiency secondary to IE as the cause of acute heart failure. Read More

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http://dx.doi.org/10.5811/cpcem.2020.3.45002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220014PMC

Austrian Syndrome in an Immunocompromised Patient-A Case Report.

Front Med (Lausanne) 2020 21;7:142. Epub 2020 Apr 21.

Department of Internal Medicine, St. Barnabas Hospital Bronx, Bronx, NY, United States.

Austrian syndrome consists of a triad of endocarditis, meningitis, and pneumonia caused by . With the arrival of many antibiotic therapies, the disease remains rare, however, it can be overlooked due to the lack of awareness. We present a case of Austrian syndrome in an immunocompromised patient complicated by multiorgan failure. Read More

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http://dx.doi.org/10.3389/fmed.2020.00142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212451PMC

Incidence and treatment costs of severe bacterial infections among people who inject heroin: A cohort study in South London, England.

Drug Alcohol Depend 2020 May 6;212:108057. Epub 2020 May 6.

National Addiction Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 4 Windsor Walk, Camberwell, London SE5 8AF, UK; South London and Maudsley NHS Foundation Trust, Monks Orchard Road Beckenham, London BR3 3BX, UK; Centre for Epidemiology and Biostatistics, Melbourne School of Global and Population Health, Level 3, 207 Bouverie Street, The University of Melbourne Victoria 3010 Australia; RAND Europe, Westbrook Centre, Milton Road, Cambridge CB4 1YG, UK.

Background: People who inject drugs often get bacterial infections. Few longitudinal studies have reported the incidence and treatment costs of these infections.

Methods: For a cohort of 2335 people who inject heroin entering treatment for drug dependence between 2006 and 2017 in London, England, we reported the rates of hospitalisation or death with primary causes of cutaneous abscess, cellulitis, phlebitis, septicaemia, osteomyelitis, septic arthritis, endocarditis, or necrotising fasciitis. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108057DOI Listing

An unusual case of endocarditis of native aortic valve following ECMO.

Indian J Thorac Cardiovasc Surg 2020 May 11:1-3. Epub 2020 May 11.

Department of Cardiac Anesthesia, Aster CMI, Bangalore, India.

Fungal endocarditis following Extracorporeal membrane oxygenation (ECMO) is rare and very rarely reported. Though rare it has a high mortality rate. A 49-year-old male patient who had venovenous ECMO presented with aortic valve endocarditis after 40 days. Read More

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http://dx.doi.org/10.1007/s12055-020-00950-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223319PMC

Infective Endocarditis Related to Unusual Microorganisms: A Prospective Population-Based Study.

Open Forum Infect Dis 2020 May 13;7(5):ofaa127. Epub 2020 Apr 13.

Maladies Infectieuses et Reanimation Médicale, Inserm CIC 1414, Hôpital Pontchaillou, Centre Hospitalo-Universitaire, Université Rennes 1, Rennes, France.

Background: Increased access to heart valves through early surgery and progress in molecular microbiology have reduced the proportion of infective endocarditis (IE) with no microbiological documentation and increased the proportion of IE associated with unusual microorganisms.

Methods: We performed an ancillary study of a large prospective population-based survey on IE. Unusual-microorganism IE was defined as definite IE (Duke-Li criteria) due to microorganisms other than streptococci, staphylococci, or enterococci. Read More

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http://dx.doi.org/10.1093/ofid/ofaa127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216922PMC

Infective endocarditis in South Africa.

Cardiovasc Diagn Ther 2020 Apr;10(2):252-261

Division of Cardiology, Department of Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.

Infective endocarditis (IE) is defined by infection of either a native or prosthetic heart valve, endocardial surface or any cardiac prosthetic device. It is a disease of both the developed and developing world, although IE has evolved in the developed world to a disease markedly different to the disease encountered in the developing world. IE in developed nations is mainly a disease of older patients with degenerative heart valve disease or cardiac prosthetic material, with virulent Staphylococci the most common causative organism. Read More

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http://dx.doi.org/10.21037/cdt.2019.06.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225416PMC

Unusual Infectious Metastases Secondary to Acupuncture Induced MSSA Septicemia.

IDCases 2020 23;20:e00759. Epub 2020 Apr 23.

Department of General Internal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston, TX, United States.

We describe a rare case of methicillin-sensitive (MSSA) septicemia with metastatic spread leading to pulmonary septic emboli, sub-capsular perinephric renal abscess, prostatic abscess, and intramuscular calf and gluteal abscess in a 48-year-old male with uncontrolled diabetes mellitus (Hemoglobin A1c of 15.2). The patient developed right lower extremity pain after a session of acupuncture followed by a three-week history of fevers, chills, abdominal pain, left flank pain, and urinary retention. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215171PMC