19,661 results match your criteria Endocardial Cushion Defects


Utility of Intracardiac Echocardiography to Guide Transseptal Catheterization for Different Electrophysiology Procedures.

Card Electrophysiol Clin 2021 Jun 24;13(2):293-301. Epub 2021 Apr 24.

Department of Cardiology, Australian National University and Canberra hospital, Canberra, Australian Capital Territory, Australia. Electronic address:

"Intracardiac echocardiography (ICE) has evolved into an indispensable tool in the armamentarium of cardiac electrophysiologists not only for understanding the internal cardiac anatomy but also for establishing transseptal access and for monitoring electrophysiology procedures. ICE aids in live monitoring of every step of the procedure including early detection of complications. Access to the left atrium through transseptal catheterization is a vital step to perform atrial fibrillation and accessory pathway ablations, ablation of left ventricular tachycardias, left atrial appendage closures, left ventricular endocardial electrode implantations for cardiac resynchronization therapies, and for selectively sampling the regions of interest during endomyocardial biopsies. Read More

View Article and Full-Text PDF

The HeartMate 6 and CardioMEMS for Fixed Pulmonary Hypertension.

ASAIO J 2021 May 12. Epub 2021 May 12.

From the Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria Division of Cardiovascular and Interventional Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria Department of Internal Medicine 3, University Hospital St. Pölten Division of Cardiac Thoracic Vascular Anaesthesia and Intensive Care Medicine, Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.

Fixed pulmonary hypertension (FPH) is a contraindication for heart transplantation (HTX). However, this condition might be reversed by continuous left-ventricular unloading with a left-ventricular assist device. We present a case of apical hypertrophic cardiomyopathy with extensive left-ventricular endocardial calcification and severe FPH (systolic pulmonary artery pressure, 102 mm Hg). Read More

View Article and Full-Text PDF

Angiotensin II Type 1 Receptor Antibody Mediated Rejection Following Orthotopic Heart Transplant: A Single Center Experience.

Transplantation 2021 Feb 22. Epub 2021 Feb 22.

1Division of Cardiology, Department of Medicine 2Department of Pathology & Immunology 3Department of Developmental Biology Washington University in St. Louis, St. Louis, MO, 63130.

Background: Antibody mediated rejection (AMR) following orthotopic heart transplant (OHT) causes significant morbidity and mortality. There is limited data on antibodies to the angiotensin II type 1 receptor (AT1R-Ab) causing rejection following OHT.

Methods: This is a retrospective, single center study that presents our 2-year experience with a series of 11 patients with evidence of nonspecific graft dysfunction and pathologic levels of AT1R-Ab. Read More

View Article and Full-Text PDF
February 2021

Parametric-based feature selection via spherical harmonic coefficients for the left ventricle myocardial infarction screening.

Med Biol Eng Comput 2021 May 13. Epub 2021 May 13.

Department of Biomedical Engineering and Medical Physics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Computer-aided diagnosis (CAD) of heart diseases using machine learning techniques has recently received much attention. In this study, we present a novel parametric-based feature selection method using the three-dimensional spherical harmonic (SHs) shape descriptors of the left ventricle (LV) for intelligent myocardial infarction (MI) classification. The main hypothesis is that the SH coefficients of the parameterized endocardial shapes in MI patients are recognizable and distinguishable from healthy subjects. Read More

View Article and Full-Text PDF

Severe Bradycardia Increases the Incidence and Severity of Torsade de Pointes Arrhythmias by Augmenting Preexistent Spatial Dispersion of Repolarization in the CAVB Dog Model.

Front Physiol 2021 26;12:642083. Epub 2021 Apr 26.

Department of Medical Physiology, Universitair Medisch Centrum Utrecht, Utrecht, Netherlands.

Introduction: Torsade de pointes arrhythmias (TdP) in the chronic atrioventricular block (CAVB) dog model result from proarrhythmic factors, which trigger TdP and/or reinforce the arrhythmic substrate. This study investigated electrophysiological and arrhythmogenic consequences of severe bradycardia for TdP.

Methods: Dofetilide (25 μg/kg per 5 min) was administered to eight anesthetized, idioventricular rhythm (IVR) remodeled CAVB dogs in two serial experiments: once under 60 beats per minute (bpm), right ventricular apex paced (RVA60) conditions, once under more bradycardic IVR conditions. Read More

View Article and Full-Text PDF

Cardiac Derived CD51-Positive Mesenchymal Stem Cells Enhance the Cardiac Repair Through SCF-Mediated Angiogenesis in Mice With Myocardial Infarction.

Front Cell Dev Biol 2021 21;9:642533. Epub 2021 Apr 21.

Department of Anatomy, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

Many tissues contained resident mesenchymal stromal/stem cells (MSCs) that facilitated tissue hemostasis and repair. However, there is no typical marker to identify the resident cardiac MSCs. We aimed to determine if CD51 could be an optimal marker of cardiac MSCs and assess their therapeutic potential for mice with acute myocardial infarction (AMI). Read More

View Article and Full-Text PDF

What are the post-ablation insular residual electrograms in the posterior left pulmonary veins electrically connected to?

Indian Pacing Electrophysiol J 2021 May 6. Epub 2021 May 6.

Division of Cardiology, Gunma Prefectural Cardiovascular Center, 3-12 Kameizumi-machi, Maebashi City, Gunma, 371-0004, Japan.

A 67-year-old man underwent a third ablation procedure for a recurrent atrial tachycardia (AT) after an extensive pulmonary vein (PV) isolation, linear ablation along the left atrial (LA) roof and posterolateral mitral isthmus (MI), and defragmentation of persistent atrial fibrillation and an induced perimitral AT. High-resolution mapping during the clinical AT using the Rhythmia system (Boston Scientific) suggested that the AT was a ridge-related reentrant AT and exhibited a reconnection of the left PVs (LPVs). The residual electrograms in the posterior LPVs were surrounded by endocardial scar, which was like an island consisting of residual LPV electrograms. Read More

View Article and Full-Text PDF

Papillary Fibroelastoma in Differential Diagnosis of Left Atrial Appendage Masses.

Tex Heart Inst J 2021 Jan;48(1)

Department of Cardiology, University of Rostock Heart Center, Rostock, Germany.

Papillary fibroelastomas are benign tumors that usually originate from cardiac valves but may have other endocardial origins. We report the cases of 2 patients in whom left atrial appendage masses were initially diagnosed as thrombus. They were treated for embolic stroke and their symptoms resolved; however, their left atrial appendage masses did not regress. Read More

View Article and Full-Text PDF
January 2021

Pre- and Postprocedural CT of Transcatheter Left Atrial Appendage Closure Devices.

Radiographics 2021 May-Jun;41(3):680-698

From the Department of Radiology (P. Rajiah, T.F., E.W.) and Department of Cardiology (M.A., J.T.), Mayo Clinic, 200 1st St SW, Rochester, MN 55905; and Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P. Ranganath).

Transcatheter left atrial appendage (LAA) closure is an alternative to long-term anticoagulation therapy in selected patients with nonvalvular atrial fibrillation who have an increased risk for stroke. LAA closure devices can be implanted by means of either an endocardial or a combined endocardial and epicardial approach. Preprocedural imaging is key to identifying contraindications, accurately sizing the device, and minimizing complications. Read More

View Article and Full-Text PDF

Epicardial-Endocardial Reentry in Ischemic Cardiomyopathy.

J Innov Card Rhythm Manag 2021 Apr 15;12(4):4467-4472. Epub 2021 Apr 15.

Department of Cardiology, Westmead Hospital, Sydney, Australia.

In ischemic cardiomyopathy, endocardial reentry has traditionally been the mechanistic paradigm for understanding ventricular tachycardia (VT). However, recognition is growing that epicardial myocardium is a critical component for VT substrate, even in patients with ischemic cardiomyopathy. In this report, we present a novel case of a three-dimensional VT reentry involving epicardial components and an endocardial exit. Read More

View Article and Full-Text PDF

Leadless Left Ventricular Endocardial Pacing and Left Bundle Branch Area Pacing for Cardiac Resynchronisation Therapy.

Arrhythm Electrophysiol Rev 2021 Apr;10(1):45-50

School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.

Cardiac resynchronisation therapy is an important intervention to reduce mortality and morbidity, but even in carefully selected patients approximately 30% fail to improve. This has led to alternative pacing approaches to improve patient outcomes. Left ventricular (LV) endocardial pacing allows pacing at site-specific locations that enable the operator to avoid myocardial scar and target areas of latest activation. Read More

View Article and Full-Text PDF

Pulsed Field Ablation of Paroxysmal Atrial Fibrillation: 1-Year Outcomes of IMPULSE, PEFCAT, and PEFCAT II.

JACC Clin Electrophysiol 2021 Apr 22. Epub 2021 Apr 22.

IHU LIRYC ANR-10-IAHU-04, Centre Hospitalier Universitaire Bordeaux, Bordeaux University, Bordeaux, France.

Objective: This study sought to determine whether durable pulmonary vein isolation (PVI) using pulsed field ablation (PFA) translates to freedom from atrial fibrillation recurrence without an increase in adverse events.

Background: PFA is a nonthermal ablative modality that, in preclinical studies, is able to preferentially ablate myocardial tissue with minimal effect on surrounding tissues. Herein, we present 1-year clinical outcomes of PFA. Read More

View Article and Full-Text PDF

Efficacy and safety of ethanol infusion into the vein of Marshall for mitral isthmus ablation.

J Cardiovasc Electrophysiol 2021 Apr 29. Epub 2021 Apr 29.

Department of Cardiology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.

Introduction: Chemical ablation by retrograde infusion of ethanol into the vein of Marshall (VOM-EI) can facilitate the achievement of mitral isthmus block. This study sought to describe the efficacy and safety of this technique.

Methods And Results: Twenty-two consecutive patients (14 males, median age 71 years) with attempted VOM-EI for mitral isthmus ablation were included in the study. Read More

View Article and Full-Text PDF

Clinical Identification and Characteristic Analysis of Giant Cell Myocarditis in 12 Cases.

Front Cardiovasc Med 2021 13;8:649094. Epub 2021 Apr 13.

State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Giant cell myocarditis (GCM) is a rare, rapidly progressing cardiomyopathy with high mortality, if not diagnosed and treated in time. We analyzed the progression and clinical manifestations of patients with definitive diagnosis of GCM. We enrolled 12 patients diagnosed with GCM in the explanted heart during heart transplantation (HTx) or by endomyocardial biopsy (EMB) and collected information on demographic data, cardiac structure and function, arrhythmias, preliminary diagnosis, and delay of the diagnosis. Read More

View Article and Full-Text PDF

Myocardial Histopathology in Patients With Obstructive Hypertrophic Cardiomyopathy.

J Am Coll Cardiol 2021 May;77(17):2159-2170

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Background: Hypertrophic cardiomyopathy (HCM) is characterized by multiple pathological features including myocyte hypertrophy, myocyte disarray, and interstitial fibrosis.

Objectives: This study sought to correlate myocardial histopathology with clinical characteristics of patients with obstructive HCM and post-operative outcomes following septal myectomy.

Methods: The authors reviewed the pathological findings of the myocardial specimens from 1,836 patients with obstructive HCM who underwent septal myectomy from 2000 to 2016. Read More

View Article and Full-Text PDF

The impact of chronic alcohol overuse on cardiac function and prognosis: layer-specific longitudinal strain and mid-term outcome analysis.

Kardiol Pol 2021 Apr 29. Epub 2021 Apr 29.

Background: The exact effects of alcohol drinking on cardiac function are not clear.

Aims: The determine the relationship between consumed amount of alcohol, myocardial injury, and prognosis.

Methods: Myocardial function and cardiac outcomes were examined in subjects with chronic alcoholism by classical and strain echocardiographic parameters, including global (GLS) and layer-specific longitudinal strain of the endocardial (GLSendo) and epicardial (GLSepi) layer. Read More

View Article and Full-Text PDF

Immunohistological Evaluation of Von Willebrand Factor in the Left Atrial Endocardium and Atrial Thrombi from Cats with Cardiomyopathy.

Animals (Basel) 2021 Apr 26;11(5). Epub 2021 Apr 26.

Department of Clinical Science and Services, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield AL9 7TA, UK.

Aortic thromboembolism (ATE) occurs in cats with cardiomyopathy and often results in euthanasia due to poor prognosis. However, the underlying predisposing mechanisms leading to left atrial (LA) thrombus formation are not fully characterised. von Willebrand Factor (vWF) is a marker of endothelium and shows increased expression following endothelial injury. Read More

View Article and Full-Text PDF

Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration.

Int J Mol Sci 2021 Apr 11;22(8). Epub 2021 Apr 11.

School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

Cardiac regenerative capacity varies widely among vertebrates. Zebrafish can robustly regenerate injured hearts and are excellent models to study the mechanisms of heart regeneration. Recent studies have shown that enhancers are able to respond to injury and regulate the regeneration process. Read More

View Article and Full-Text PDF

Outflow Tract Formation-Embryonic Origins of Conotruncal Congenital Heart Disease.

J Cardiovasc Dev Dis 2021 Apr 9;8(4). Epub 2021 Apr 9.

Aix-Marseille Université, INSERM, MMG, U1251, 27 boulevard Jean Moulin, 13005 Marseille, France.

Anomalies in the cardiac outflow tract (OFT) are among the most frequent congenital heart defects (CHDs). During embryogenesis, the cardiac OFT is a dynamic structure at the arterial pole of the heart. Heart tube elongation occurs by addition of cells from pharyngeal, splanchnic mesoderm to both ends. Read More

View Article and Full-Text PDF

A Systematic Review on the Correlations between Left Atrial Strain and Cardiovascular Outcomes in Chronic Kidney Disease Patients.

Diagnostics (Basel) 2021 Apr 8;11(4). Epub 2021 Apr 8.

Nephrology Clinic, Dialysis, and Renal Transplant Center-'C.I. Parhon' University Hospital, 700503 Iasi, Romania.

Left atrial strain (LASr) represents a relatively new but promising technique for left atrial and left ventricle function evaluation. LASr was strongly linked to myocardial fibrosis and endocardial thickness, suggesting the utility of LASr in subclinical cardiac dysfunction detection. As CKD negatively impacts cardiovascular risk and mortality, underlying structural and functional abnormalities of cardiac remodeling are widely investigated. Read More

View Article and Full-Text PDF

Echocardiographic diagnosis of atrial cardiomyopathy allows outcome prediction following pulmonary vein isolation.

Clin Res Cardiol 2021 Apr 29. Epub 2021 Apr 29.

Division of Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, Suedring 15, 79189, Bad Krozingen, Germany.

Background: Relevant atrial cardiomyopathy (ACM), defined as a left atrial (LA) low-voltage area ≥ 2 cm at 0.5 mV threshold on endocardial contact mapping, is associated with new-onset atrial fibrillation (AF), higher arrhythmia recurrence rates after pulmonary vein isolation (PVI), and an increased risk of stroke. The current study aimed to assess two non-invasive echocardiographic parameters, LA emptying fraction (EF) and LA longitudinal strain (LAS, during reservoir (LASr), conduit (LAScd) and contraction phase (LASct)) for the diagnosis of ACM and prediction of arrhythmia outcome after PVI. Read More

View Article and Full-Text PDF

Histopathological Characterization of Mitral Valvular Lesions from Patients with Rheumatic Heart Disease.

Arq Bras Cardiol 2021 Mar;116(3):404-412

Universidade Federal de Minas Gerais, Belo Horizonte, MG - Brasil.

Background: The underlying mechanisms by which rheumatic heart disease (RHD) lead to severe valve dysfunction are not completely understood.

Objective: The present study evaluated the histopathological changes in mitral valves (MV) seeking an association between the pattern of predominant valvular dysfunction and histopathological findings.

Methods: In 40 patients who underwent MV replacement due to RHD, and in 20 controls that underwent heart transplant, histological aspects of the excised MV were analyzed. Read More

View Article and Full-Text PDF

Epicardial ablation of recurrent left atrial macroreentrant tachycardia from Bachmann's bundle region after endocardial ablation.

Pacing Clin Electrophysiol 2021 Apr 28. Epub 2021 Apr 28.

Hacettepe University, Faculty of Medicine, Department of Cardiology, Ankara, Turkey.

Bachmann's bundle is a common site of possible epicardial connection in addition to coronary sinus, Marshall ligament and septopulmonary bundle. Hereby, we presented the image of epicardial ablation for recurrent perimitral macroreentry after endocardial ablation. Endocardial mapping revealed discontinuous activation pattern. Read More

View Article and Full-Text PDF

Malignant Melanoma in a Long-legged Buzzard (): Characterization of Clinical and Histologic Lesions.

J Avian Med Surg 2021 Apr;35(1):80-85

ZooParc de Beauval & Beauval Nature, Route du Blanc, 41110 Saint Aignan sur Cher, France.

A 17-year-old, male long-legged buzzard () presented for acute lethargy and black gelatinous tissue in both nostrils. Despite intensive care, the bird died within 2 days. A postmortem computed tomographic scan of the head revealed a complete obstruction of the rostral infraorbital sinus, later confirmed by necropsy. Read More

View Article and Full-Text PDF

Intraprocedural arrhythmia termination as an end point for hybrid ablation in patients with long-standing persistent atrial fibrillation: a 2-year follow-up study.

Interact Cardiovasc Thorac Surg 2021 Apr 23. Epub 2021 Apr 23.

Department of Cardiology, Hebei Yanda Hospital, Hebei, Hebei Province, China.

Objectives: Hybrid catheter and surgical ablation has emerged as an effective therapy for patients with persistent atrial fibrillation (AF). The aims of this study were to evaluate the relationship between intraprocedural arrhythmia termination and the long-term outcomes of hybrid ablation in patients with long-standing persistent AF.

Methods: From May 2015 through April 2019, 50 patients with persistent AF with a mean duration of 73. Read More

View Article and Full-Text PDF

Optimizing Impedance Change Measurement During Radiofrequency Ablation Enables More Accurate Characterization of Lesion Formation.

JACC Clin Electrophysiol 2021 Apr 25;7(4):471-481. Epub 2020 Nov 25.

Faculty of Engineering and Information Technology, University of Sydney, Sydney, Australia.

Objectives: This study sought to determine whether a novel impedance thermal imaging system (ITIS) provides an impedance measurement that is better correlated with lesion dimensions than circuit impedance during radiofrequency (RF) ablation.

Background: A 5- to 10-Ω impedance drop is clinically used to corroborate an effective RF ablation lesion. However, the contribution of local tissue heating to circuit impedance change is small and dependent on the local environment of the catheter and placement of the grounding patch. Read More

View Article and Full-Text PDF

Sympathetic Blockade for the Management of Refractory Ventricular Tachycardia: A Case Report.

A A Pract 2021 Apr 21;15(4):e01456. Epub 2021 Apr 21.

From the Department of Anesthesiology, Perioperative and Pain Medicine.

A 64-year-old man with a history of nonischemic cardiomyopathy (NICM) presented with electrical storm (ES). Episodes of ventricular tachycardia (VT) persisted despite endocardial catheter ablations and exhaustive pharmacotherapy. We used alternating regional anesthesia techniques, left stellate ganglion block, and proximal intercostal block to reduce sympathetic input to the heart, resulting in a significant decrease in VT burden. Read More

View Article and Full-Text PDF

Original Article--Outcomes of Pacing in Egyptian Pediatric Population.

J Saudi Heart Assoc 2021 15;33(1):61-70. Epub 2021 Apr 15.

Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Objectives: Permanent pacemakers are widely used in the pediatric population due to congenital and surgically acquired rhythm disturbances. The diversity and complexity of congenital heart diseases make device management a highly individualized procedure in pediatric pacing. We are also faced with special problems in pediatric age group as growth, children's activity and infection susceptibility. Read More

View Article and Full-Text PDF

Fully Automatic Scar Segmentation for Late Gadolinium Enhancement MRI Images in Left Ventricle with Myocardial Infarction.

Curr Med Sci 2021 Apr 20;41(2):398-404. Epub 2021 Apr 20.

College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, 310027, China.

Numerous methods have been published to segment the infarct tissue in the left ventricle, most of them either need manual work, post-processing, or suffer from poor reproducibility. We proposed an automatic segmentation method for segmenting the infarct tissue in left ventricle with myocardial infarction. Cardiac images of a total of 60 diseased hearts (55 human hearts and 5 porcine hearts) were used in this study. Read More

View Article and Full-Text PDF

Definity, echo contrast, induced cardiac arrest: brief review of the literature.

BMJ Case Rep 2021 Apr 19;14(4). Epub 2021 Apr 19.

John D Dingel VA hospital Detroit, Detroit, Michigan, USA.

Definity is a contrast media used to enhance the endocardium during echocardiography. Cardiac arrest as an adverse reaction to Definity is still a debate. We are presenting a rare case of a 69-year-old male patient who developed cardiopulmonary arrest immediately after Definity injection during resting echocardiography. Read More

View Article and Full-Text PDF