28,525 results match your criteria Endemic Syphilis


Enigma of serpiginous choroiditis.

Indian J Ophthalmol 2019 Mar;67(3):325-333

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Serpiginous choroiditis (SC) is an asymmetrically bilateral inflammation of the choroid that leads to loss of choriocapillaris atrophy or loss of overlying retinal pigment epithelium. Over the last few decades, SC has passed through a long evolution of nomenclature, etiologies and morphological variations. Initially diagnosed in patients with tuberculosis and syphilis, SC was predominantly considered as autoimmune process. Read More

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http://dx.doi.org/10.4103/ijo.IJO_822_18DOI Listing

Increased Methamphetamine, Injection Drug, and Heroin Use Among Women and Heterosexual Men with Primary and Secondary Syphilis - United States, 2013-2017.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):144-148. Epub 2019 Feb 15.

Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC.

During 2013-2017, the national annual rate of reported primary and secondary (P&S) syphilis cases in the United States increased 72.7%, from 5.5 to 9. Read More

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http://dx.doi.org/10.15585/mmwr.mm6806a4DOI Listing
February 2019
2 Reads

[Sexually Transmitted Infections - What's New, What's Different?]

Dtsch Med Wochenschr 2019 Feb 31;144(3):165-170. Epub 2019 Jan 31.

Abteilung Infektiologie, Klinik für Innere Medizin II, Universitätsklinikum Freiburg.

The incidence of sexually transmitted infections like syphilis or gonorrhea is still rising, particularly in the high-risk population of men having sex with men (MSM). Neisseria gonorrhoeae is capable to develop resistance to all antibiotics previously or currently used for treatment. Dual antimicrobial therapy with ceftriaxone and azithromycin is considered the current empirical first-line therapy. Read More

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http://dx.doi.org/10.1055/a-0655-6657DOI Listing
February 2019
5 Reads

Epidemiology survey of infectious diseases in North Korean travelers, 2015-2017.

BMC Infect Dis 2019 Jan 5;19(1):13. Epub 2019 Jan 5.

Department of Infectious Diseases, Bethune International Peace Hospital, NO.398, Zhongshanxi Road, Shijiazhuang, Hebei Prov, 050082, People's Republic of China.

Background: Up until now, there are limited studies available on the epidemiology of infectious diseases in Democratic People's Republic of Korea (DPRK, North Korea). However, different types of infectious diseases have been found in North Korean travelers at Dandong port. Entry surveillance data of those North Korean travelers may provide some insight into the probable epidemiology of some infectious diseases in DPRK. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3664-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321685PMC
January 2019
1 Read

Laboratory evaluation of four HIV/syphilis rapid diagnostic tests.

BMC Infect Dis 2019 Jan 3;19(1). Epub 2019 Jan 3.

HIV/STI Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Sexually transmitted infections, such as HIV and syphilis, are one of the major health care problems worldwide, especially in low- and middle income countries. HIV screening programmes have been widely used for many years. The introduction of rapid point-of-care tests (RDTs) that can detect both HIV and syphilis, using one single blood specimen, would be a promising tool to integrate the detection of syphilis into HIV programmes and so improve the accessibility of syphilis testing and treatment. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3567-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318958PMC
January 2019
5 Reads

Topical treatment with gallium maltolate reduces Treponema pallidum subsp. pertenue burden in primary experimental lesions in a rabbit model of yaws.

PLoS Negl Trop Dis 2019 01 2;13(1):e0007076. Epub 2019 Jan 2.

Innovation to End Neglected Diseases (IT-ENDs), East Palo Alto, CA, United States of America.

Background: Gallium is a semi-metallic element known since the 1930s to have antimicrobial activity. This activity stems primarily from gallium's ability to mimic trivalent iron and disrupt specific Fe(III)-dependent pathways, particularly DNA synthesis (due to inhibition of ribonucleotide reductase). Because of its novel mechanism of action, gallium is currently being investigated as a new antibacterial agent, particularly in light of the increasing resistance of many pathogenic bacteria to existing antibiotics. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331133PMC
January 2019
2 Reads

Generalized Convulsive Status Epilepticus Secondary to Jarisch-Herxheimer Reaction in Neurosyphilis: A Case Report and Literature Review.

Neurologist 2019 Jan;24(1):29-32

Department of Neurology, Health Sciences Center, Federal University of Santa Maria, Rio Grande do Sul, Brazil.

Introduction: Jarisch-Herxheimer reaction (JHR) is defined as a transient immunologic reaction, classically seen in patients during syphilis treatment. JHR is a rare cause of status epilepticus (SE) in neurosyphilis. We describe a case of generalized convulsive SE (GCSE) probably secondary to JHR in a patient with neurosyphilis. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000219DOI Listing
January 2019
2 Reads

Dual screen and confirm rapid test does not reduce overtreatment of syphilis in pregnant women living in a non-venereal treponematoses endemic region: a field evaluation among antenatal care attendees in Burkina Faso.

Sex Transm Infect 2018 Dec 22. Epub 2018 Dec 22.

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Objectives: In resource-limited settings, screening pregnant women for syphilis using rapid diagnostic tests (RDTs) is a key tool in the prevention of congenital syphilis. However, most syphilis RDTs detect only treponemal antibodies (T-RDT), meaning antibiotics may be provided unnecessarily to previously treated pregnant women, particularly in non-venereal treponematoses endemic regions. We estimated the potential reduction in overtreatment when comparing T-RDT (SD Bioline) to a newer rapid test (Dual Path Platform (DPP) Screen and Confirm Assay, Chembio) detecting both treponemal and non-treponemal antibodies. Read More

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http://dx.doi.org/10.1136/sextrans-2018-053722DOI Listing
December 2018

Limited efficacy of nontreponemal test combined with treponemal test in the initial syphilis screening algorithm.

J Med Microbiol 2019 Feb 20;68(2):216-220. Epub 2018 Dec 20.

1​Department of Bacteriology, Centre de Biologie Humaine, Centre Hospitalo-Universitaire Amiens Picardie, Amiens, France.

Purpose: Various syphilis screening algorithms have been proposed and are now used by many clinical laboratories following the introduction of automated treponemal tests (TTs). In France, the diagnosis of syphilis is based on a TT combined with a nontreponemal test (NTT). The objective of this study was to evaluate the diagnostic impact of NTT on initial syphilis screening at the Amiens University Hospital between January 2013 and December 2016. Read More

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http://dx.doi.org/10.1099/jmm.0.000886DOI Listing
February 2019

A spatiotemporal meta-analysis of HIV/syphilis epidemic among men who have sex with men living in mainland China.

BMC Infect Dis 2018 Dec 12;18(1):652. Epub 2018 Dec 12.

Dermatology Hospital, Southern Medical University, Guangzhou, 510095, Guangdong, China.

Background: Geographic differences in HIV, syphilis and condomless sex among men who have sex with men in China remained unknown. We aimed to elucidate these spatiotemporal changing patterns in China.

Methods: We conducted a spatiotemporal meta-analysis. Read More

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http://dx.doi.org/10.1186/s12879-018-3532-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292157PMC
December 2018
2.613 Impact Factor

Congenital Conundrum.

Authors:
Sean Price

Tex Med 2018 Jul 1;114(7):42-43. Epub 2018 Jul 1.

Physicians fight Texas' stubborn rates of congenital infections. Syphillis, CMV, and HIV are the top three. Read More

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Jarisch-Herxheimer reaction in a patient with syphilis and human immunodeficiency virus infection.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):877-878

Programa de Pós-Graduação Stricto Sensu em Ciências da Saúde, Universidade Federal do Maranhão, São Luís, MA, Brasil.

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http://dx.doi.org/10.1590/0037-8682-0419-2017DOI Listing
February 2019
3 Reads

Syphilis in pregnancy, congenital syphilis, and factors associated with mother-to-child transmission in Itapeva, São Paulo, 2010 to 2014.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):819-826

Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil.

Introduction: This study describes cases of syphilis in pregnancy (SiP) and congenital syphilis (CS) and identifies factors associated with mother-to-child transmission in patients in Itapeva from January 1, 2010 to December 31, 2014.

Methods: Using SiP and CS notification forms and medical records, a cross-sectional study involving 149 pregnant women was conducted.

Results: Annual SiP detection rates ranged from 16. Read More

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http://dx.doi.org/10.1590/0037-8682-0377-2017DOI Listing
February 2019
2 Reads

Prevalence and risk factors of syphilis and human immunodeficiency virus co-infection at a university hospital in Brazil.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):813-818

Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, PE, Brasil.

Introduction: The incidence of syphilis has increased since the 1970s.

Methods: This was a descriptive and analytical cross-sectional study with a non-probabilistic sample.

Results: Of 973 patients with human immunodeficiency virus, 179 (18. Read More

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http://dx.doi.org/10.1590/0037-8682-0097-2018DOI Listing
February 2019
2 Reads

Prioritizing surveillance activities for certification of yaws eradication based on a review and model of historical case reporting.

PLoS Negl Trop Dis 2018 12 4;12(12):e0006953. Epub 2018 Dec 4.

Institute of Tropical Medicine, Antwerp, Belgium.

Background: The World Health Organization (WHO) has targeted yaws for global eradication. Eradication requires certification that all countries are yaws-free. While only 14 Member States currently report cases to WHO, many more are known to have a history of yaws and some of them may have ongoing transmission. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294396PMC
December 2018
9 Reads

High rate of seromarkers for HIV, HBV and syphilis among blood donors using confidential unit exclusion, before and after HIV-NAT implementation at a major public blood bank in the Brazilian Amazon.

Transfusion 2019 Feb 30;59(2):629-638. Epub 2018 Nov 30.

Tropical Pathology and Public Health Institute, Federal University of Goias, Goiania, Brazil.

Background: Confidential unit exclusion (CUE) was introduced in the 1980's as an additional layer to blood safety, before highly specific and sensitive nucleic acid tests (NAT) for HIV were implemented. The utility of CUE-use in settings that have implemented NAT should be evaluated over time.

Study Design, Methods: Cross-sectional retrospective study carried out from June 2010-November 2015, at Manaus Hemocenter (HEMOAM), Amazonas, Brazil that implemented HIV-NAT in 2012. Read More

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http://dx.doi.org/10.1111/trf.15045DOI Listing
February 2019
4 Reads

Syphilis prevalence and risk factors among young men presenting to the Brazilian Army in 2016: Results from a national survey.

Medicine (Baltimore) 2018 Nov;97(47):e13309

Department of Surveillance, Prevention and Control of STI, HIV/AIDS and Viral Hepatitis, Secretariat of Health Surveillance, Ministry of Health of Brazil, Brasília, DF, Brazil.

The Conscripts Survey has been conducted periodically by the Brazilian Department of Sexually Transmitted Infections (STIs), AIDS, and Viral Hepatitis (DIAHV) in collaboration with the Brazilian Ministry of Defense for over 2 decades. It aims to assess the syphilis prevalence and obtain data on knowledge regarding STIs and their risk factors among conscripts enlisted for the Brazilian Army.This cross-sectional study was conducted among conscripts across Brazil aged 17 to 22 years from August to December 2016. Read More

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http://dx.doi.org/10.1097/MD.0000000000013309DOI Listing
November 2018
13 Reads
5.723 Impact Factor

Forty cases of acquired oral syphilis and a review of the literature.

Int J Oral Maxillofac Surg 2018 Nov 17. Epub 2018 Nov 17.

Diagnostic Centre for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, RS, Brazil.

The aim of this study was to describe 40 cases of acquired oral syphilis (AOS) and to discuss the distribution of demographic characteristics, clinical features, and differential diagnosis of the disease. A retrospective study was conducted covering a 17-year period at a single institution in southern Brazil. Moreover, a literature review was performed through a search of the PubMed database for articles on AOS published between 1955 and March 2018. Read More

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http://dx.doi.org/10.1016/j.ijom.2018.10.023DOI Listing
November 2018
2 Reads

Lack of antiretroviral therapy is associated with higher risk of neurosyphilis among HIV-infected patients who remain serofast after therapy for early syphilis.

Medicine (Baltimore) 2018 Nov;97(45):e13171

Department of Dermatology.

Resolution of clinical symptoms and at least 4-fold decline in nontreponemal antibody titers after treatment of syphilis is regarded as "proof of cure." However, a substantial proportion of patients demonstrates <4-fold reduction of titers after recommended therapy (serofast state). It remains unclear whether the serofast state is indicative of persistence of bacteria or only a residual immune response. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0007
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http://dx.doi.org/10.1097/MD.0000000000013171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250445PMC
November 2018
16 Reads

First Paleogenetic Evidence of Probable Syphilis and Treponematoses Cases in the Brazilian Colonial Period.

Biomed Res Int 2018 10;2018:8304129. Epub 2018 Oct 10.

Laboratório de Biologia de Tripanosomatídeos (LABTRIP), Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil.

Despite interest in the origins of syphilis, paleopathological analysis has not provided answers, and paleogenetic diagnosis remains a challenge. Even venereal syphilis has low infectivity which means there are few circulating bacteria for most of the individual's life. Human remains recovered from the Nossa Senhora do Carmo Church (17th to 19th centuries) and the Praça XV Cemetery (18th to 19th centuries), Rio de Janeiro, Brazil, were subjected to paleogenetic analysis. Read More

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http://dx.doi.org/10.1155/2018/8304129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199871PMC
February 2019
2 Reads

Immunogenicity and protective efficacy against Treponema pallidum in New Zealand rabbits immunized with plasmid DNA encoding flagellin.

Emerg Microbes Infect 2018 Nov 7;7(1):177. Epub 2018 Nov 7.

Institute of Pathogenic Biology, Medical College, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China.

Plasmid DNA encoding flagellin FlaB3 was used as a vaccination candidate for the evaluation of immunogenicity and protection against Treponema pallidum subsp. pallidum dissemination. First, intramuscular injection of the flagellin encoded by the plasmid DNA into New Zealand rabbits elicited both humoral and cellular immune responses. Read More

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http://www.nature.com/articles/s41426-018-0176-0
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http://dx.doi.org/10.1038/s41426-018-0176-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220273PMC
November 2018
14 Reads

Urogenital pathogens, associated with Trichomonas vaginalis, among pregnant women in Kilifi, Kenya: a nested case-control study.

BMC Infect Dis 2018 Nov 6;18(1):549. Epub 2018 Nov 6.

Laboratory Bacteriology Research, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan, 185, Ghent, Belgium.

Background: Screening of curable sexually transmitted infections is frequently oriented towards the diagnosis of chlamydia, gonorrhea, syphilis and trichomoniasis, whereas other pathogens, sometimes associated with similar urogenital syndromes, remain undiagnosed and/or untreated. Some of these pathogens are associated with adverse pregnancy outcomes.

Methods: In a nested case-control study, vaginal swabs from 79 pregnant women, i. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3455-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219184PMC
November 2018
19 Reads

Prevalence of Plasmodium parasitaemia in blood donors and a survey of the knowledge, attitude and practices of transfusion malaria among health workers in a hospital in Kumasi, Ghana.

PLoS One 2018 5;13(11):e0206303. Epub 2018 Nov 5.

Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Malaria is one of the transfusion transmissible infections in malaria endemic countries such as Ghana. Healthy blood donors may harbour Plasmodium parasites without showing signs of malaria. Blood from such donors constitutes a risk to transfusion recipients and the recipients of this blood may go on to develop transfusion transmitted malaria (TTM). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206303PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218034PMC
November 2018
9 Reads

Epidemiology of HIV, syphilis, and hepatitis B and C among manual cane cutters in low-income regions of Brazil.

BMC Infect Dis 2018 Nov 3;18(1):546. Epub 2018 Nov 3.

Faculty of Nursing, Federal University of Goias/Universidade Federal de Goiás, Goiânia, GO, Brazil.

Background: In recent decades the epidemic of asymptomatic sexually transmitted infections has extended deep into Brazil, including small towns and rural areas. The purpose of this study was to investigate the epidemiology of HIV, syphilis, and hepatitis B (HBV) and hepatitis C viruses (HCV), and to evaluate immunization coverage against hepatitis B in a group of rural workers in Brazil.

Methods: In 2016, a cross-sectional study was conducted with 937 manual sugarcane cutters of the Midwest and Northeast Regions of Brazil. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3439-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215621PMC
November 2018
10 Reads

Comparison of three syphilis algorithms in West China.

Clin Chim Acta 2019 Jan 31;488:76-80. Epub 2018 Oct 31.

Division of Clinical microbiology, Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, PR China. Electronic address:

Objective: The study was designed to analyze three different algorithms with the implementation of treponemal tests for detecting suspected syphilis in west China where no syphilis algorithms guideline exists.

Methods: We retrospectively collected data to reanalyze three syphilis testing algorithms: the classical reverse algorithm, and two options of syphilis screening in European syphilis guideline. The kappa (κ) coefficients were used to compare the concordance between algorithms using different syphilis assays during two periods. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981183056
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http://dx.doi.org/10.1016/j.cca.2018.10.038DOI Listing
January 2019
7 Reads

Prevalence and risk factors of HTLV-1/2 and other blood borne infectious diseases among blood donors in Yaounde Central Hospital, Cameroon.

Pan Afr Med J 2018 13;30:125. Epub 2018 Jun 13.

Department of Medical Microbiology and Immunology, School of Health Sciences-Catholic University of Central Africa, Yaoundé Cameroon.

Introduction: Transfusion-transmissible infectious microorganisms including bacteria and viruses are among the greatest threats to blood safety for the recipient. The prevalence and risk factors of HTLV-1/2 and other blood borne infectious diseases were determined among blood donors in Yaounde Central Hospital, Cameroon.

Methods: Design: cross sectional study. Read More

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http://www.panafrican-med-journal.com/content/article/30/125
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http://dx.doi.org/10.11604/pamj.2018.30.125.14802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201601PMC
November 2018
5 Reads

Associations between digital dermatitis lesion grades in dairy cattle and the quantities of four Treponema species.

Vet Res 2018 Oct 29;49(1):111. Epub 2018 Oct 29.

Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.

Digital dermatitis (DD) presents as painful, ulcerative or proliferative lesions that lead to bovine lameness affecting economic efficiency and animal welfare. Although DD etiological agent(s) have not been established, it is widely accepted that DD is a polymicrobial disease significantly associated with species of Treponema and the non-linear disease progression may be attributed to interactions among infecting bacteria. We postulated the morphological changes associated with DD lesion grades are related to interactions among infecting species of Treponema. Read More

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https://veterinaryresearch.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13567-018-0605-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206660PMC
October 2018
12 Reads

Blood-borne and sexually transmitted infections: a cross-sectional study in a Swiss prison.

BMC Infect Dis 2018 Oct 29;18(1):539. Epub 2018 Oct 29.

Division of Prison Health, Geneva University Hospitals, University of Geneva, Chemin de Champ-Dollon 22, 1241 Puplinge, Geneva, Switzerland.

Background: Incarcerated people carry a high burden of infection, including blood-borne diseases (BBDs). It is also known that one million people contract a sexually transmitted infection (STI) every day worldwide, which represents a global public health challenge. However, data regarding the prevalence of STIs and the risk factors among incarcerated populations are lacking. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3445-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206665PMC
October 2018
14 Reads

Spatial-temporal clustering analysis of yaws on Lihir Island, Papua New Guinea to enhance planning and implementation of eradication programs.

PLoS Negl Trop Dis 2018 10 29;12(10):e0006840. Epub 2018 Oct 29.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

Background: In the global program for the eradication of yaws, assessments of the prevalence of the disease are used to decide where to initiate mass treatment. However, the smallest administrative unit that should be used as the basis for making decisions is not clear. We investigated spatial and temporal clustering of yaws to help inform the choice of implementation unit. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224128PMC
October 2018

Surveillance of Maternal Syphilis in China: Pregnancy Outcomes and Determinants of Congenital Syphilis.

Med Sci Monit 2018 Oct 29;24:7727-7735. Epub 2018 Oct 29.

Department of Perinatal Health Care, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China (mainland).

BACKGROUND We sought to describe the epidemiological characteristics of pregnant women with syphilis in Beijing, China, and to investigate the determinants of adverse pregnancy outcomes, including congenital syphilis. MATERIAL AND METHODS We used data from laboratory-confirmed syphilis-infected women who delivered between 2013 and 2015 and were registered in China's Information Management System for Prevention of Mother-to-Child Transmission of Syphilis. Sociodemographic, clinical, and prevention predictors of adverse pregnancy outcomes (i. Read More

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http://dx.doi.org/10.12659/MSM.910216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216479PMC
October 2018
1 Read

Turin's breakdown: Nietzsche's pathographies and medical rationalities.

Cien Saude Colet 2018 Oct;23(10):3421-3431

Centro de Educação de Ciências Humanas, Departamento de Psicologia, Universidade Federal de Sergipe. Av. Marechal Rondon s/n, Jardim Rosa Elze. 49100-000 São Cristóvão SE Brasil.

At age 44, after suffering a breakdown in Turin, philosopher Friedrich Nietzsche was diagnosed with neurosyphilis. There was no necropsy on his body, so this medical diagnosis has been questioned over the time. We conducted a literature review on the medical diagnosis of Nietzsche, which emphasizes three genres of pathographies that emerged successively as alternatives explanations for Nietzsche's breakdown in Turin: (1) narratives about syphilis ("demoniac-pathological"); (2) narratives about functional psychosis ("heroic-prophetic"); (3) other narratives about organic diseases, other than syphilis ("scientific-realistic"). Read More

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http://dx.doi.org/10.1590/1413-812320182310.25602016DOI Listing
October 2018
6 Reads

Syphilitic Alopecia.

N Engl J Med 2018 Oct;379(17):1657

Hospital of the University of Pennsylvania, Philadelphia, PA

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http://dx.doi.org/10.1056/NEJMicm1804118DOI Listing
October 2018
2 Reads

Comparison of Clinical and Laboratory Characteristics of General Paresis and Non-Neurosyphilis Dementia.

Eur Neurol 2018 19;80(1-2):82-86. Epub 2018 Oct 19.

Zhongshan Hospital, Medical College of Xiamen University, Xiamen,

Background: The differential diagnosis of general paresis (GP) and non-neurosyphilis (NS) dementia is not clearly defined. The present study examined the differences in clinical and laboratory features of GP and non-NS dementia.

Materials And Methods: We retrospectively examined clinical and laboratory features of 85 GP patients and 196 non-NS dementia patients. Read More

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http://dx.doi.org/10.1159/000493866DOI Listing
January 2019
4 Reads

Édouard Manet's Tabes Dorsalis: From Painful Ataxia to Phantom Limb.

Front Neurol Neurosci 2018 18;43:59-75. Epub 2018 Oct 18.

Édouard Manet (1832-1883) is considered the "father" of impressionism and even of twentieth century modern art. Manet's genius involved getting away from the classical narrative or historical topics and replacing them by the banality of daily life. Technically, he erased volumes into flat two-dimensional coloured planes, and distorted conventional perspective with often gross brushstrokes intentionally giving an "unfinished" aspect to the work. Read More

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http://dx.doi.org/10.1159/000490405DOI Listing
January 2019
1 Read

HIV test uptake and related factors amongst heterosexual drug users in Shandong province, China.

PLoS One 2018 18;13(10):e0204489. Epub 2018 Oct 18.

Department of STI and Leprosy Prevention and Control, Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China.

Background: In China, the mode of HIV transmission and the types and routes of drug use have changed in the past decade. HIV testing amongst drug users needs further improvement.

Methods: Interviewer-administered questionnaires were used for data collection amongst 600 heterosexual drug users from the community and a municipal detention centre, where criminal suspects are supervised. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204489PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193625PMC
October 2018
6 Reads

Congenital syphilis in the USA.

Authors:
The Lancet

Lancet 2018 10;392(10154):1168

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http://dx.doi.org/10.1016/S0140-6736(18)32360-2DOI Listing
October 2018
1 Read

Candidate Treponema pallidum biomarkers uncovered in urine from individuals with syphilis using mass spectrometry.

Future Microbiol 2018 10 12;13:1497-1510. Epub 2018 Oct 12.

Laboratory for Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.

Aim: A diagnostic test that could detect Treponema pallidum antigens in urine would facilitate the prompt diagnosis of syphilis.

Materials & Methods: Urine from 54 individuals with various clinical stages of syphilis and 6 controls were pooled according to disease stage and interrogated with complementary mass spectrometry techniques to uncover potential syphilis biomarkers.

Results & Conclusion: In total, 26 unique peptides were uncovered corresponding to four unique T. Read More

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https://www.futuremedicine.com/doi/10.2217/fmb-2018-0182
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http://dx.doi.org/10.2217/fmb-2018-0182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367768PMC
October 2018
14 Reads

Strategy for performing treponemal tests in reverse-sequence algorithms of syphilis diagnosis.

Clin Biochem 2019 Jan 2;63:121-125. Epub 2018 Oct 2.

Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea.

Objectives: In South Korea, automated T. pallidum Latex Agglutination (TPLA) based on turbidoimmunoassays and immunochromatographic assay (ICA) are widely used for syphilis diagnosis. However, there is sparse data on the validation of these assays in the reverse-sequence algorithm setting. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00099120183076
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http://dx.doi.org/10.1016/j.clinbiochem.2018.09.013DOI Listing
January 2019
8 Reads

Lessons from a comparison of immuno-chromatographic and chemiluminescent micro-particle immunoassay in the diagnosis of syphilis.

BMC Res Notes 2018 Oct 4;11(1):701. Epub 2018 Oct 4.

Pathology Laboratory Department, Research Section, Livingstone Central Hospital, Akapelwa Street, P.O. Box 60091, Livingstone, Zambia.

Objective: To synthesize lessons from comparison of results obtained from the immuno-chromatographic SD Bioline testing method and the chemiluminescent micro-particle immunoassay Architect in the diagnosis of syphilis at Livingstone Central hospital laboratory.

Results: The specificity and sensitivity of SD Bioline syphilis 3.0 against the chemiluminescent immunoassay using the Architect syphilis Treponema pallidum (TP) was 85. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-018-3808-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172779PMC
October 2018
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Factors Contributing to Congenital Syphilis Cases - New York City, 2010-2016.

MMWR Morb Mortal Wkly Rep 2018 Oct 5;67(39):1088-1093. Epub 2018 Oct 5.

Congenital syphilis occurs when syphilis is transmitted from a pregnant woman to her fetus; congenital syphilis can be prevented through screening and treatment during pregnancy. Transmission to the fetus can occur at any stage of maternal infection, but is more likely during primary and secondary syphilis, with rates of transmission up to 100% at these stages (1). Untreated syphilis during pregnancy can cause spontaneous abortion, stillbirth, and early infant death. Read More

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http://www.cdc.gov/mmwr/volumes/67/wr/mm6739a3.htm?s_cid=mm6
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http://dx.doi.org/10.15585/mmwr.mm6739a3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171893PMC
October 2018
19 Reads

A high burden of asymptomatic genital tract infections undermines the syndromic management approach among adolescents and young adults in South Africa: implications for HIV prevention efforts.

BMC Infect Dis 2018 Oct 3;18(1):499. Epub 2018 Oct 3.

Perinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Youth in southern Africa, particularly adolescent girls and young women, are a key population for HIV prevention interventions. Untreated genital tract infections (GTIs) increase both HIV transmission and acquisition risks. South African GTI treatment guidelines employ syndromic management, which relies on individuals to report GTI signs and symptoms. Read More

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http://dx.doi.org/10.1186/s12879-018-3380-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171143PMC
October 2018
3 Reads

Syphilis reinfection is associated with an attenuated immune profile in the same individual: a prospective observational cohort study.

BMC Infect Dis 2018 Sep 25;18(1):479. Epub 2018 Sep 25.

Immunology Unit, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Ascertaining if the clinical and immunological response to repeat syphilis differs from that in initial syphilis may assist in designing optimal syphilis screening strategies and vaccine design.

Methods: We prospectively recruited 120 patients with a new diagnosis of (baseline) syphilis. During a 24-month follow-up period, 11 of these patients had a further diagnosis of (repeat) syphilis. Read More

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http://dx.doi.org/10.1186/s12879-018-3399-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156855PMC
September 2018
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Prevalence and treatment of sexually transmitted infections in men followed by urologists in Germany - a cross sectional study with 347,090 men.

Ger Med Sci 2018 13;16:Doc03. Epub 2018 Aug 13.

Epidemiology, QuintilesIMS, Frankfurt, Germany.

The goal of this retrospective analysis was to study the prevalence and treatment of the most common sexually transmitted infections (STI) in men followed by urologists in Germany. This study included a total of 347,090 men followed in 71 urology practices in Germany between 2013 and 2015. The first outcome was the prevalence of individuals diagnosed with STI between 2013 and 2015. Read More

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http://www.egms.de/en/journals/gms/2018-16/000265.shtml
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http://dx.doi.org/10.3205/000265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124731PMC
January 2019
5 Reads

Public health response to large influx of asylum seekers: implementation and timing of infectious disease screening.

BMC Public Health 2018 Sep 24;18(1):1139. Epub 2018 Sep 24.

Department of Health Security, Infectious Disease Control and Vaccinations Unit, National Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.

Background: Infectious disease screening of migrants at increased risk is a feature of national infection prevention and control measures. Asylum seekers in Finland are offered screening of tuberculosis (TB), hepatitis B, human immunodeficiency virus infection (HIV) and syphilis based on individual risk assessment. We aimed to evaluate the public health response to a large influx of asylum seekers to Finland in 2015-2016 with respect to national guidelines on initial health services and infectious disease screening. Read More

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http://dx.doi.org/10.1186/s12889-018-6038-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154941PMC
September 2018
2 Reads

Prevalence of Sexually Transmitted Infections among Married Women in Rural Nepal.

Infect Dis Obstet Gynecol 2018 26;2018:4980396. Epub 2018 Aug 26.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Introduction: We have previously determined the prevalence of human papillomavirus (HPV) infection among women in rural Nepal. In the current study, we also wanted to examine the prevalence of and risk factors for other sexually transmitted infections (STIs) in the same population.

Methods: Population-based study of nonpregnant women ≥ 15 years who were married or had a history of marriage in the past, residing in five rural villages in Nepal. Read More

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https://www.hindawi.com/journals/idog/2018/4980396/
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http://dx.doi.org/10.1155/2018/4980396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129351PMC
January 2019
15 Reads

Isolation and identification of Treponema pedis and Treponema phagedenis-like organisms from bovine digital dermatitis lesions found in dairy cattle in Turkey.

J Dairy Sci 2018 Nov 13;101(11):10317-10326. Epub 2018 Sep 13.

Laboratory of Diagnostics and Analysis, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyon, 03200, Turkey.

The isolation and identification of microorganisms associated with digital dermatitis (DD) in Turkish dairy cattle was investigated using punch skin biopsy samples from typical clinical lesions; they were collected from dairy farms and abattoirs in 5 different geographical locations in Turkey. Morphological characteristics and flagellation types were examined using a transmission electron microscope, and their enzyme profiles by enzyme activation kits; their catalase reaction characteristics were evaluated by the addition of 3% HO. Their phylogenies were identified using 16S rRNA and the results compared with known gene bank data. Read More

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http://dx.doi.org/10.3168/jds.2017-14227DOI Listing
November 2018

Improvement of reverse sequence algorithm for syphilis diagnosis using optimal treponemal screening assay signal-to-cutoff ratio.

PLoS One 2018 13;13(9):e0204001. Epub 2018 Sep 13.

Centre hospitalier de l'Université de Montréal, Département de microbiologie médicale et infectiologie, Montréal, Québec, Canada.

Background: Although reverse sequence algorithms (RSA) for syphilis screening are performing well, they still have to rely on treponemal confirmatory tests at least for sera reactive by enzyme immunoassay/chemiluminescence immunoassay (EIA/CIA) and unreactive by rapid plasma reagin (RPR). Quebec's laboratory network previously showed that 3.3% of EIA/CIA reactive and weakly-reactive RPR samples (RPR titer of 1 to 4) would have been misclassified as syphilis cases if a treponemal confirmatory test had not been performed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204001PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136794PMC
September 2018
2 Reads

[Ocular syphilis: a warning sign of an HIV infection].

Ned Tijdschr Geneeskd 2018 08 30;162. Epub 2018 Aug 30.

Erasmus MC, afd. Oogheelkunde, Rotterdam.

A 29-year-old male presented at the ER with a red and painful left eye with sudden and progressive loss of vision within a week. His visual acuity was 1/60. Slit lamp investigation showed inflammatory cells throughout the anterior chamber and vitreous body, and a hyperaemic and swollen optic disc with retinal lesions, indicating a panuveitis combined with multifocal chorioretinitis. Read More

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August 2018
12 Reads

[Intraurban differentials in congenital syphilis: a predictive analysis by neighborhood in the city of Rio de Janeiro, Brazil].

Cad Saude Publica 2018 09 6;34(9):e00105517. Epub 2018 Sep 6.

Instituto de Comunicação e Informação Científica e Tecnológica em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.

The study aimed to characterize notified cases of congenital syphilis from 2011 to 2014 in the city of Rio de Janeiro and to analyze possible associations between congenital syphilis and living conditions in the city's neighborhoods. Cases of congenital syphilis were characterized according to biological and socioeconomic variables and health services use. At the aggregate level, regression tree technique was used for the data analysis, with mean incidence rate (2011-2014) of congenital syphilis as the dependent variable and housing quality, schooling, income, teenage pregnancy, poverty density, access to prenatal care, and skin color as independent variables. Read More

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http://dx.doi.org/10.1590/0102-311X00105517DOI Listing
September 2018
13 Reads

Evaluation of three automated Treponema pallidum antibody assays for syphilis screening.

J Infect Chemother 2018 Nov 7;24(11):887-891. Epub 2018 Sep 7.

Department of Clinical Laboratory, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, China. Electronic address:

The accuracy of the test is critical for the syphilis serology diagnosis. This study aims to evaluate the values of the Elecsys syphilis assay, the Architect syphilis assay, and the Mindray syphilis assay, as syphilis screening tests for pregnant women and patients with syphilis or other diseases. A reverse algorithm was used for the syphilis serology diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1341321X183023
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http://dx.doi.org/10.1016/j.jiac.2018.07.017DOI Listing
November 2018
10 Reads