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    1 OF 552

    Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999-2012.
    Emerg Infect Dis 2017 May;23(5):816-819
    Survey results showed treponemal infection among pet macaques in Southeast Asia, a region with a high prevalence of human yaws. This finding, along with studies showing treponemal infection in nonhuman primates in Africa, should encourage a One Health approach to yaws eradication and surveillance activities, possibly including monitoring of nonhuman primates in yaws-endemic regions. Read More

    The PICASSO Cohort: baseline characteristics of a cohort of men who have sex with men and male-to-female transgender women at high risk for syphilis infection in Lima, Peru.
    BMC Infect Dis 2017 Apr 11;17(1):255. Epub 2017 Apr 11.
    David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.
    Background: Men who have sex with men (MSM) and male-to-female transgender women (transwomen) are disproportionately at risk of syphilis infection in Peru.

    Methods: From 2013 to 2014, MSM and transwomen seeking human immunodeficiency virus (HIV) or sexually transmitted infection (STI) testing and/or treatment were recruited into a 2-year observational cohort study to determine predictors of recently acquired syphilis infection (defined as a rapid plasma reagin [RPR] titer ≥1:16 and a reactive treponemal antibody test) in Lima, Peru. At baseline, interviewers collected sociodemographic, behavioral, and medical characteristics from participants. Read More

    State-Specific Rates of Primary and Secondary Syphilis Among Men Who Have Sex with Men - United States, 2015.
    MMWR Morb Mortal Wkly Rep 2017 Apr 7;66(13):349-354. Epub 2017 Apr 7.
    In 2015, the rate of reported primary and secondary syphilis in the United States was 7.5 cases per 100,000 population, nearly four times the previous lowest documented rate of 2.1 in 2000 (1). Read More

    Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively.
    PLoS Negl Trop Dis 2017 Mar 6;11(3):e0005434. Epub 2017 Mar 6.
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    Background: Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan. Read More

    DIAGNOSIS OF ENDOCRINE DISEASE: Expanding the cause of hypopituitarism.
    Eur J Endocrinol 2017 Jun 3;176(6):R269-R282. Epub 2017 Mar 3.
    School of MedicineUniversity of Belgrade, Belgrade, Serbia
    Hypopituitarism is defined as one or more pituitary hormone deficits due to a lesion in the hypothalamic-pituitary region. By far, the most common cause of hypopituitarism associated with a sellar mass is a pituitary adenoma. A high index of suspicion is required for diagnosing hypopituitarism in several other conditions such as other massess in the sellar and parasellar region, brain damage caused by radiation and by traumatic brain injury, vascular lesions, infiltrative/immunological/inflammatory diseases (lymphocytic hypophysitis, sarcoidosis and hemochromatosis), infectious diseases and genetic disorders. Read More

    Seroprevalence of hepatitis B, hepatitis C, human immunodeficiency virus, Treponema pallidum, and co-infections among blood donors in Kyrgyzstan: a retrospective analysis (2013-2015).
    Infect Dis Poverty 2017 Feb 21;6(1):45. Epub 2017 Feb 21.
    TWINCORE, Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625, Hannover, Germany.
    Background: Post-Soviet Kyrgyzstan has experienced a major surge in blood-borne infections, but data from adequately powered, up-to-date studies are lacking. We thus examined a) the seroprevalences of hepatitis B virus surface antigen (HBsAg), HIV-1 p24 antigen and antibodies against hepatitis C virus (anti-HCV), human immunodeficiency viruses (anti-HIV-1/2, HIV-1 group O), and Treponema pallidum among blood donors in Kyrgyzstan and assess their distribution according to sex, age, and provinces of residence; b) trends in the respective seroprevalences; and c) co-infection rates among the pathogens studied.

    Methods: Serological screening was performed on 37 165 blood donors at the Republican Blood Centre in Bishkek, Kyrgyzstan, between January 2013 and December 2015. Read More

    Concurrent central nervous system infective pathology in a severely immunocompromised patient.
    J Family Med Prim Care 2016 Jul-Sep;5(3):685-687
    Department of Internal Medicine, Interfaith Medical Center, Brooklyn, New York, USA.
    To our knowledge and literature search, concurrent cryptococcal meningitis and neurosyphilis in a patient have rarely been reported. Here, we report a 37-year-old male with HIV infection presented with headache and dizziness for 5 days along with memory difficulty and personality changes for about 1 week. During the hospital stay, cryptococcal meningitis was confirmed with positive cerebral spinal fluid (CSF) cryptococcal antigen titer (1:320) and positive CSF culture. Read More

    Single Dose Versus 3 Doses of Intramuscular Benzathine Penicillin for Early Syphilis in HIV: A Randomized Clinical Trial.
    Clin Infect Dis 2017 Mar;64(6):759-764
    Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, and.
    Background.: Patients coinfected with syphilis and human immunodeficiency virus (HIV) may have a slower decrease in rapid plasma reagin (RPR) titers. Currently a single dose of 2. Read More

    Infectious Diseases and Immunizations in International Adoption.
    Pediatr Ann 2017 Feb;46(2):e56-e60
    Children who are adopted internationally have an increased risk of infectious diseases due to endemic conditions and variable access to preventive health care, such as vaccines, in their country of origin. Pediatricians and other providers who care for children should be familiar with the recommended screening for newly arrived international adoptees. Testing for gastrointestinal pathogens, tuberculosis, hepatitis, syphilis, and HIV should be routinely performed. Read More

    [CXCL-13 as a biomarker in the diagnostics of neuroborreliosis].
    Nervenarzt 2017 Feb 9. Epub 2017 Feb 9.
    Abteilung für Neurologie, Universitätsklinikum St. Pölten, KLPU, Propst Führer-Straße 4, 3100, St. Pölten, Österreich.
    Background: The chemokine CXCL-13 is a potential intrathecal biomarker for neuroborreliosis (NB). According to the literature the sensitivity of CXCL-13 in the diagnostics of NB varies between 88% and 100% and the specificity between 63% and 99.7%. Read More

    Risk Factors for Incidence of Sexually Transmitted Infections Among Women in a Human Immunodeficiency Virus Chemoprevention Trial: VOICE (MTN-003).
    Sex Transm Dis 2017 Mar;44(3):135-140
    From the *University of Zimbabwe-University of California San Francisco Research Program, Harare, Zimbabwe; †SCHARP at Fred Hutchinson Cancer Research Center; ‡Department of Biostatistics, University of Washington, Seattle, WA; §Magee-Women's Research Institute, Pittsburgh, PA; ¶Medical Research Council, HIV Prevention Research Unit, Durban, South Africa; ∥CAPRISA-University of KwaZulu Natal, Durban, South Africa; **MU-JHU Research Collaboration, Kampala, Uganda; ††Division of AIDS/NIAID/US National Institutes of Health, Bethesda, MD; ‡‡University of Pittsburgh, Pittsburgh, PA; and §§University of Alabama at Birmingham, AL.
    Background: In sub-Saharan Africa, there are limited data on the incidence of sexually transmitted infections (STIs) among women, largely because routine screening for asymptomatic infection is not performed. We conducted a secondary analysis to measure STI incidence rates and determine risk factors for new STI acquisition among women enrolled in the VOICE trial.

    Methods: We analyzed data from 4843 women screened for chlamydia, gonorrhoea, syphilis, and trichomonas infection at baseline, annually, at interim visits when clinically indicated and at their study termination visit. Read More

    Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.
    Protein Sci 2017 Apr 23;26(4):847-856. Epub 2017 Mar 23.
    Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390.
    The spirochete Treponema pallidum is the causative agent of syphilis, a sexually transmitted infection of major global importance. Other closely related subspecies of Treponema also are the etiological agents of the endemic treponematoses, such as yaws, pinta, and bejel. The inability of T. Read More

    A retrospective cross-sectional quantitative molecular approach in biological samples from patients with syphilis.
    Microb Pathog 2017 Mar 2;104:296-302. Epub 2017 Feb 2.
    Reference Laboratory of Bacterial Sexually Transmitted Infections, Department of Infectious Diseases, National Institute of Health, Av. Padre Cruz, 1649-016, Lisbon, Portugal; Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health, Av. Padre Cruz, 1649-016, Lisbon, Portugal. Electronic address:
    Syphilis is the sexually transmitted disease caused by Treponema pallidum, a pathogen highly adapted to the human host. As a multistage disease, syphilis presents distinct clinical manifestations that pose different implications for diagnosis. Nevertheless, the inherent factors leading to diverse disease progressions are still unknown. Read More

    Depression and HIV Risk Behaviors among Female Sex Workers in Guangdong, China: A Multicenter Cross-Sectional Study.
    Biomed Res Int 2016 20;2016:6986173. Epub 2016 Dec 20.
    Guangdong Provincial Center for Skin Disease and STI Control, Guangzhou, Guangdong 510091, China.
    Background. Our study aimed to assess the burden of depression and evaluate factors associated with depression and status of HIV risk behaviors among female sex workers (FSWs) in Guangdong, China. Method. Read More

    Granulomatous & histiocytic dermatitides.
    Semin Diagn Pathol 2016 Dec 14. Epub 2016 Dec 14.
    Section of Dermatopathology, Division of Surgical & Cytological Pathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:
    Granulomas of the skin may be classified in several ways. They are either infectious or non-infectious in character, and they contain areas of necrobiosis or necrosis, or not. Responsible infectious agents may be mycobacterial, fungal, treponemal, or parasitic organisms, and each case of granulomatous dermatitis should be assessed histochemically for those microbes. Read More

    Factors associated with syphilis incidence in the HIV-infected in the era of highly active antiretrovirals.
    Medicine (Baltimore) 2017 Jan;96(2):e5849
    aDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich bInstitute of Medical Virology, University of Zurich, Zurich cBasel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel dInfectious Diseases Department, Genève University Hospital, Genève eInfectious Diseases Department, Lausanne University Hospital, Lausanne fDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel gDivision of Infectious Diseases and Hospital Epidemiology, Kantonal Hospital St. Gallen, St. Gallen hDivision of Infectious Diseases, Regional Hospital Lugano, Lugano iDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
    After several years of steady decline, syphilis is reemerging globally as a public health hazard, especially among people living with human immunodeficiency virus (HIV). Syphilis resurgence is observed mainly in men who have sex with men (MSM), yet other transmission groups are affected too. In this manuscript, we study the factors associated with syphilis incidence in the Swiss HIV cohort study in the era of highly effective antiretrovirals. Read More

    Anti-N-methyl-D-aspartate receptor(NMDAR) antibody encephalitis presents in atypical types and coexists with neuromyelitis optica spectrum disorder or neurosyphilis.
    BMC Neurol 2017 Jan 5;17(1). Epub 2017 Jan 5.
    Department of neurology, Beijing Ditan Hospital, Capital Medical University, No.8 East Jing Shun Rd, Chaoyang District, Beijing, China.
    Background: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a clinically heterogeneous disorder characterized by epileptic seizures, psychosis, dyskinesia, consciousness impairments, and autonomic instability. Symptoms are always various. Sometimes it presents in milder or incomplete forms. Read More

    Could lengthening minocycline therapy better treat early syphilis?
    Medicine (Baltimore) 2016 Dec;95(52):e5773
    Department of Dermatovenereology, Tianjin Medical University General Hospital, Tianjin, China.
    Syphilis is a sexually transmitted disease caused by Treponema pallidum. Minocycline, a representative tetracycline derivative, has the greatest antimicrobial activity among all tetracyclines. There are few reports about treating syphilis with minocycline because there is a lack of efficacy data from controlled trials. Read More

    Analytical and clinical comparison of Elecsys syphilis (Roche(®)) - Architect syphilis TP and reformulated Architect syphilis TP (Abbott(®)) assay.
    Diagn Microbiol Infect Dis 2017 Mar 9;87(3):210-212. Epub 2016 Dec 9.
    Department of Laboratory Medicine, AZ St Jan Bruges, Bruges, Belgium. Electronic address:
    The performance of Elecsys Syphilis was compared to Architect Syphilis TP and Reformulated Architect Syphilis TP. The overall sensitivity and specificity were 98.4% and 99. Read More

    Seroprevalence and diagnosis of HIV, HBV, HCV and syphilis infections among blood donors.
    Hum Antibodies 2017 ;25(1-2):39-55
    Department of Biology, Faculty of Natural & Computational Sciences, Woldia University, Woldia, Ethiopia.
    Background: Blood transfusion is one of the most important therapeutic options of life-saving intervention for recipients who are in diseased or non-diseased conditions with severe blood loss. However, it is associated with certain risks which can lead to adverse consequences that may cause acute or delayed complications and bring the risk of transfusion-transmissible infections including HIV, Hepatitis B & C and Syphilis. So, there might be a fatal risk instead of life saving. Read More

    [Untreated syphilis - from Oslo to Tuskegee].
    Tidsskr Nor Laegeforen 2016 Dec 20;136(23-24):2010-2016. Epub 2016 Dec 20.
    Institutt for helse og samfunn Universitetet i Oslo.
    In the period from 1891 - 1910, around 2000 patients with syphilis were admitted to the Department of Dermatology, Oslo University Hospital, Rikshospitalet. The head of the department, Cæsar Boeck (1845 - 1917), believed in allowing the disease to take its natural course and withheld treatment. He made detailed notes of the diagnosis and the clinical course of the disease for all his patients. Read More

    Postal censorship of Bosnian public health institutions during the Second World War: The Independent State of Croatia versus Dr. Stanko Sielski.
    Acta Med Acad 2016 Nov;45(2):171-174
    Department of Medical Sciences, Academy of Sciences and Arts of Bosnia and Herzegovina.
    This study aims to present evidence of censorship during World War II by the Independent State of Croatia of one of its public health officials, Dr. Stanko Sielski who was a physician trained in epidemiology and public health. During World War II, he directed the Institute for Combating Endemic Syphilis in the Bosnian town Banja Luka. Read More

    Syphilis.
    Lancet 2017 Apr 18;389(10078):1550-1557. Epub 2016 Dec 18.
    University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:
    Syphilis is a chronic bacterial infection caused by Treponema pallidum that is endemic in low-income countries and and occurs at lower rates in middle-income and high-income countries. The disease is of both individual and public health importance and, in addition to its direct morbidity, increases risk of HIV infection and can cause lifelong morbidity in children born to infected mothers. Without treatment the disease can progress over years through a series of clinical stages and lead to irreversible neurological or cardiovascular complications. Read More

    Auckland: city of syphilis?
    N Z Med J 2016 Dec 16;129(1447):57-63. Epub 2016 Dec 16.
    Sexual Health Physician, Auckland Regional Sexual Health Service, Auckland District Health Board, Auckland.
    Aims: To briefly report on the large increase in cases of syphilis managed at Auckland Regional Sexual Health Service (ARSHS) in 2015. To raise awareness of syphilis as an emerging significant public health issue in Auckland.

    Method: A search was conducted of the electronic patient management system at ARSHS for cases of syphilis diagnosed between 1st of January 2015 and 31st of December 2015. Read More

    Performance of Syphilis Sentinel Surveillance in the context of endemic Treponematoses: experience from Ghana.
    BMC Infect Dis 2016 Dec 9;16(1):745. Epub 2016 Dec 9.
    London School of Hygiene and Tropical Medicine, London, UK.
    Background: Use of treponemal tests to screen for syphilis (caused by Treponema pallidum pallidum) poses challenges with infection status classification, especially in settings where other treponemal infections are endemic. This study aimed to determine the validity of the syphilis surveillance testing strategy implemented since 2004 using two treponemal tests, and estimate the seroprevalence of active syphilis infection in Ghana where yaws (caused by Treponema pallidum pertenue) is endemic.

    Methods: We retested sera from the 2007 HIV sentinel survey (HSS) using a traditional algorithm, quantitative rapid plasma reagin test followed by qualitative Treponema pallidum haemagglutination assay. Read More

    Sexually Transmitted Infections: Recommendations from the U.S. Preventive Services Task Force.
    Am Fam Physician 2016 Dec;94(11):907-915
    Agency for Healthcare Research and Quality, Rockville, MD, USA.
    The U.S. Preventive Services Task Force (USPSTF) has issued recommendations on behavioral counseling to prevent sexually transmitted infections (STIs) and recommendations about screening for individual STIs. Read More

    Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster.
    Nat Microbiol 2016 Dec 5;2:16245. Epub 2016 Dec 5.
    Institute for Evolutionary Biology and Environmental Studies, University of Zurich, 8057 Zurich, Switzerland.
    The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history(1). Surprisingly, despite the availability of effective antibiotic treatment since the mid-twentieth century, this bacterial infection, which is caused by Treponema pallidum subsp. pallidum (TPA), has been re-emerging globally in the last few decades with an estimated 10. Read More

    Comparative analysis of motility and other properties of Treponema denticola strains.
    Microb Pathog 2017 Jan 30;102:82-88. Epub 2016 Nov 30.
    Department of Microbiology, School of Dentistry, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, Aichi 464-8650, Japan.
    The periodontitis-associated pathogen Treponema denticola is a spirochetal bacterium that swims by rotating its cell body like a corkscrew using periplasmic flagella. We compared physiologic and pathogenic properties, including motility, in four strains of T. denticola. Read More

    Re-evaluating the sensitivity of the rabbit infectivity test for Treponema pallidum in modern era.
    Clin Chim Acta 2017 Jan 20;464:136-141. Epub 2016 Nov 20.
    Clinical Laboratory, Zhongshan Hospital, Medical College of Xiamen University, Xiamen 361004, China. Electronic address:
    Background: The rabbit infectivity test (RIT) was previously described as a highly-sensitive method for clinically detecting Treponema pallidum. But our primary study indicated this result may have changed in current antibiotics era.

    Methods: By inoculating rabbits testis with cerebrospinal fluid (CSF) (n=63) and exudate from hard chancre lesions (n=13), we re-evaluated the sensitivity of RIT in modern era. Read More

    Treponema, Iron and Neurodegeneration.
    Curr Alzheimer Res 2016 11 21. Epub 2016 Nov 21.
    Department of Bacteriology , Université de Rennes 1, 2, avenue du Professeur Léon Bernard, 35043 Rennes, France.
    Spirochetes are suspected to be linked to the genesis of neurological diseases, including neurosyphillis or neurodegeneration (ND). Impaired iron homeostasis has been implicated in loss of function in several enzymes requiring iron as a cofactor, formation of toxic oxidative species, inflammation and elevated production of beta-amyloid proteins. This review proposes to discuss the link that may exist between the involvement of Treponema spp. Read More

    Syphilis in females in Bialystok, Poland, 2000-2015
    Przegl Epidemiol 2016;70(2):273-280
    WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
    Introduction: Syphilis, similar to most other sexually transmitted infections, disproportionally affects females more than males, including the risk of adverse outcome of pregnancy and infection in foetus.

    Objective: To describe and analyse all cases of syphilis among female patients (pregnant and non-pregnant) treated in Bialystok, Poland in 2000-2015.

    Material And Methods: Retrospective analysis of sociodemographic, epidemiological and clinical characteristics of pregnant and non-pregnant syphilis-positive females. Read More

    School-based interventions for preventing HIV, sexually transmitted infections, and pregnancy in adolescents.
    Cochrane Database Syst Rev 2016 11 8;11:CD006417. Epub 2016 Nov 8.
    Department of Health Sciences, University of York, Seebohm Rowntree Building, Heslington, York, UK, YO10 5DD.
    Background: School-based sexual and reproductive health programmes are widely accepted as an approach to reducing high-risk sexual behaviour among adolescents. Many studies and systematic reviews have concentrated on measuring effects on knowledge or self-reported behaviour rather than biological outcomes, such as pregnancy or prevalence of sexually transmitted infections (STIs).

    Objectives: To evaluate the effects of school-based sexual and reproductive health programmes on sexually transmitted infections (such as HIV, herpes simplex virus, and syphilis), and pregnancy among adolescents. Read More

    Sexually Transmitted Infections Among Hospitalized Patients With Human Immunodeficiency Virus Infection and Acquired Immune Deficiency Syndrome (HIV/AIDS) in Zahedan, Southeastern Iran.
    Int J High Risk Behav Addict 2016 Sep 2;5(3):e28028. Epub 2016 Jul 2.
    Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran.
    Background: Studies show that nearly 40 million people are living with human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) around the world and since the beginning of the epidemic, about 35 million have died from AIDS. Heterosexual intercourse is the most common route for transmission of HIV infection (85%). People with a sexually transmitted infection (STI), such as syphilis, genital herpes, chancroid, or bacterial vaginosis, are more likely to obtain HIV infection during sex. Read More

    Increased incidence of syphilis in men who have sex with men and risk management strategies, Germany, 2015.
    Euro Surveill 2016 Oct;21(43)
    Robert Koch Institute, Unit for HIV/AIDS, STI and blood-borne infections, Berlin, Germany.
    In Germany, the number of reported syphilis cases increased between 11% and 22% per year between 2010 and 2014. We analysed syphilis surveillance data and data of four behavioural surveys on men who have sex with men (MSM) in Germany (2003, 2007, 2010, 2013) to assess if this rise is ongoing and to find possible explanations for it. Syphilis notifications increased in 2015 by 19% to a total of 6,834. Read More

    Ocular Syphilis - Eight Jurisdictions, United States, 2014-2015.
    MMWR Morb Mortal Wkly Rep 2016 Nov 4;65(43):1185-1188. Epub 2016 Nov 4.
    Ocular syphilis, a manifestation of Treponema pallidum infection, can cause a variety of ocular signs and symptoms, including eye redness, blurry vision, and vision loss. Although syphilis is nationally notifiable, ocular manifestations are not reportable to CDC. Syphilis rates have increased in the United States since 2000. Read More

    Macrophage migration inhibitory factor as a novel cerebrospinal fluid marker for neurosyphilis among HIV-negative patients.
    Clin Chim Acta 2016 Dec 15;463:103-108. Epub 2016 Oct 15.
    Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China; Xiamen Zhongshan Hospital, Fujian Medical University, Xiamen, China. Electronic address:
    Background: Neurosyphilis (NS) is difficult to diagnose, especially in syphilis patients with negative cerebrospinal fluid (CSF) rapid plasma reagin (RPR) or Venereal Disease Research Laboratory (VDRL) tests.

    Methods: We conducted a cross-sectional study and an analysis of macrophage migration inhibitory factor (MIF) in syphilitic patients to identify a novel marker for the diagnosis of NS, with a focus on probable NS (NS with negative VDRL/RPR tests). For this purpose, CSF and serum MIF concentrations were determined in 43 NS and 43 syphilis/non-NS (N-NS) patients at the Zhongshan Hospital of the Medical College of Xiamen University from July 2014 to June 2015. Read More

    Syphilis: an atypical case of sepsis and multiple anogenital lesions in secondary syphilis.
    J Community Hosp Intern Med Perspect 2016 26;6(5):32495. Epub 2016 Oct 26.
    Department of Internal Medicine, University of Illinois Peoria Campus, OSF Saint Francis Medical Center, Peoria, IL, USA.
    The incidence of syphilis has historically been cyclical in nature, often in relation to the rise and fall of public health initiatives directed toward eradication along with social attitudes toward sexual practices. The incidence of syphilis has increased by 15% in the last 6 years in the United States, with similar increases worldwide. Herein, we present an atypical case of syphilis presenting with severe septic shock and multiple anogenital lesions in an immunocompetent host. Read More

    Misdiagnosed neurosyphilis associated with prolonged psychosis.
    Acta Neuropsychiatr 2016 Dec 6;28(6):362-364. Epub 2016 Jun 6.
    School of Osteopathic Medicine,Rowan University,Psychiatry,2250 Chapel Ave,Suite 100,Cherry Hill,NJ,USA.
    Objective: After the prevalence of syphilis had reached historic lows, the Center for Disease Control devised a plan to eradicate syphilis in the United States. Since that decree there has been a dramatic rise in new cases. Psychosis is an ominous symptom of neurosyphilis. Read More

    Diagnosing neurosyphilis: a case of confusion.
    BMJ Case Rep 2016 Oct 27;2016. Epub 2016 Oct 27.
    Barts Health NHS Trust, London, UK.
    A Pakistani man aged 60 years presented with personality change, aggression, paranoid delusions and sexual disinhibition while being treated for severe chest sepsis in intensive care. Collateral history confirmed that these personality changes had been developing over the course of the previous 2 years. He was found to have positive syphilis serology during a routine confusion screen, and the possibility of neurosyphilis was raised. Read More

    Clinical Evaluation of Fully Automated Elecsys(®) Syphilis Assay for the Detection of Antibodies of Treponema pallidum.
    J Clin Lab Anal 2016 Nov 26;30(6):1164-1168. Epub 2016 May 26.
    Division of Clinical Microbiology, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
    Objective: The resurgence of syphilis in recent years has become a serious threat to the public health worldwide, and the serological detection of specific antibodies against Treponema pallidum (TP) remains the most reliable method for laboratory diagnosis of syphilis. The performance of the Elecsys(®) Syphilis assay, a brand new electrochemiluminescene immunoassay (ECLIA), was assessed by large amounts of samples in this study.

    Methods: In comparison with InTec assay, the Elecsys(®) Syphilis assay was evaluated in 146 preselected samples from patients with syphilis, 1803 clinical routine samples, and 175 preselected samples from specific populations with reportedly increased rates of false-positive syphilis test results. Read More

    Nerve-stretching in the 19th century.
    J Med Biogr 2016 Nov 19;24(4):537-545. Epub 2015 Feb 19.
    National Spinal Injuries Centre, Stoke Mandeville Hospital, Herts, UK.
    Operative nerve-stretching was first described in 1872 to relieve incurable pain from sciatica and tabes dorsalis. It became popular for 20 years and numerous articles were published on the subject. It had many complications but relief was only transient and, consequently, it fell into disuse. Read More

    The life and work of the Dumfries surgeon James Hill (1703-1776): his contributions to the management of cancer and of head injury.
    J Med Biogr 2016 Nov 12;24(4):459-468. Epub 2014 Nov 12.
    Royal College of Surgeons of Edinburgh, Edinburgh, UK
    James Hill was apprenticed to the formidable Edinburgh surgeon, physician and philosopher George Young from whom he learned the value of careful observation and scepticism in medicine. As a surgeon in Dumfries he was able to take advantage of newly established medical journals to publish case reports. His book Cases in Surgery summarised three aspects of his life's work as a surgeon. Read More

    [A Case of Rectal Syphilis Incidentally Found at Regular Medical Check-up].
    Korean J Gastroenterol 2016 Oct;68(4):218-220
    Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Syphilis is a rare disease in the rectum. It is difficult to diagnose because the characteristics of the rectal syphilis rectal lesion are highly varied. The endoscopic findings of rectal syphilis are proctitis, ulcers, and masses. Read More

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