30,018 results match your criteria Endemic Syphilis


Uptake of Primary Care Services and HIV and Syphilis Infection among Transgender Women attending the Tangerine Community Health Clinic, Bangkok, Thailand, 2016 - 2019.

J Int AIDS Soc 2021 Jun;24(6):e25683

Institute of HIV Research and Innovation, Bangkok, Thailand.

Introduction: Transgender women (TGW) need a specific package of primary care services usually not available in the publicly funded healthcare system. In addition, little is known about HIV and syphilis prevalence and incidence in clinic-based samples of TGW. Here we evaluate the uptake of a transgender-specific package of primary care services by TGW in Bangkok, Thailand and assess HIV and syphilis prevalence and incidence among them. Read More

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Diagnostic strategies for oral manifestations of infectious diseases.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Apr;50(2):141-147

Department. of Oral Medicine.

Infectious diseases are caused by infection of organism with pathogenic agents, which may lead to epidemics. Many infectious diseases such as syphilis, diphtheria, measles, and acquired immunodeficiency syndrome have specific and non-specific manifestations in the oral cavity. However, the same disease may have different oral manifestations in different patients clinically. Read More

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Improvement of quality of care for gestational syphilis in the municipality of Rio de Janeiro.

Rev Saude Publica 2021 14;55:34. Epub 2021 Jun 14.

Universidade Federal do Rio Grande do Norte. Centro de Ciências da Saúde. Departamento de Saúde Coletiva. Natal, RN, Brasil.

Objective: To analyze the effect of a multifaceted intervention in the care of pregnant women with syphilis in primary health care.

Methods: This is a quality improvement project performed in 26 basic care units in the municipality of Rio de Janeiro, between January and December 2017. It has a quasi-experimental mixed design, with previous, later and time series analyses. Read More

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Unusual erythematous plaque with white scales, a case of acquired syphilis in a child and literature review.

BMC Infect Dis 2021 Jun 5;21(1):528. Epub 2021 Jun 5.

Department of Dermatology, The First Hospital of China Medical University, 155N. Nanjing Street, Shenyang, 110001, P. R. China.

Background: Syphilis in children is uncommon with the mode of infection for this rare condition likely being congenital or acquired. While most acquired cases of syphilis in children result from sexual abuse, children can also be infected with syphilis through kissing, breastfeeding, sharing of daily necessities or pre-chewed food. Here, we report a case of acquired secondary syphilis in a child due to consumption of pre-chewed-food and provide a review of the literature on the characteristics of acquired syphilis in preschool children. Read More

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Unexplained multi-sensory neuropathy syndrome in young Tanzanian adults.

J Glob Health Rep 2021 30;5. Epub 2021 Mar 30.

Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

Background: A unique syndrome affecting young adults of unexplained hearing loss often associated with uncorrectable poor visual acuity and lower extremity numbness is endemic in Dar es Salaam. This study characterized the hearing loss, associated it with other symptoms, and gathered information on potential causes.

Methods: Forty-seven patients (23 men, 24 women) <40 years old with a symptom consistent with the syndrome, negative syphilis test, and no head injury history were recruited from Muhimbili National Hospital. Read More

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Unusual clinical manifestation and challenging serological interpretation of syphilis: insights from a case report.

BMC Infect Dis 2021 Jun 2;21(1):521. Epub 2021 Jun 2.

STI/HIV Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy.

Background: The clinical manifestations of recent syphilis can be variable, with typical and atypical patterns. Several conditions may cause atypical clinical aspects, including human immunodeficiency virus (HIV) co-infection. Besides the clinical features, co-infections may completely alter syphilis serological tests, causing interpretative difficulties and diagnostic delays. Read More

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Seroprevalence of Hepatitis B, Hepatitis C, Human Immunodeficiency Virus, syphilis, and malaria among blood donors at tertiary care hospital blood bank.

J Pak Med Assoc 2021 Mar;71(3):897-899

Dow University of Health Sciences, Karachi, Pakistan.

Objective: To ascertain the frequency of markers of transfusion-transmitted infections among blood donors in a tertiary care setting.

Methods: The retrospective cross-sectional descriptive study, was conducted in the Blood Bank section of the Department of Pathology at the Dow University of Health Sciences, Karachi, and comprised data of blood donors from January 2013, to October 2018. All blood donors had been screened for hepatitis B, hepatitis C, human immunodeficiency virus I and II, syphilis through electrochemiluminescence and malaria using immunochromatography. Read More

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Syphilis diagnosis and serological response to Benzanthine Penicilline G among patients attending in HIV clinics in N'Djaména, Chad.

Int J Infect Dis 2021 May 26. Epub 2021 May 26.

Pathogenesis and Control of Chronic Infections, University of Montpellier, INSERM, EFS, Montpellier, France. Electronic address:

Background: Syphilis is endemic in Sub-Saharan zone and disproportionately affect at-risk populations such as of men who have sex with men, sex workers and HIV infected individuals. In this study, we measure the impact of syphilis among people living with HIV in the Republic of Chad, where no data are currently available.

Method: Outpatients attending in two HIV clinics in N'Djamena, republic of Chad were tested for syphilis. Read More

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Social network distribution of syphilis self-testing among men who have sex with men in China: study protocol for a cluster randomized control trial.

BMC Infect Dis 2021 May 27;21(1):491. Epub 2021 May 27.

Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, China.

Background: Syphilis is a common sexually transmitted infection (STI) among men who have sex with men (MSM). Increasing syphilis testing is important to syphilis control. However, in low- and middle-income countries like China, syphilis testing rates remain low among MSM. Read More

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Clinical Features of Ocular Pathology in Patients with Acquired Immunodeficiency Syndrome and Syphilis.

Adv Ther 2021 06 21;38(6):3362-3372. Epub 2021 May 21.

Beijing Tongren Eye Center, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.

Introduction: The present study aimed to analyze the clinical features of ocular pathology in patients with acquired immunodeficiency syndrome (AIDS) combined with syphilis.

Methods: A total of 129 patients with AIDS and syphilis who first visited the Department of Ophthalmology in Beijing YouAn Hospital between 2012 and 2019 were included in the study. All patients underwent ophthalmologic examinations, such as best-corrected visual acuity (BCVA), slit lamp, intraocular pressure, dilated fundus examination, and color fundus photography as well as systemic examinations related to AIDS and syphilis. Read More

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Attitudes and Perceptions About Disclosing HIV and Syphilis Results Using Smarttest, a Smartphone App Dedicated to Self- and Partner Testing.

AIDS Educ Prev 2021 06;33(3):234-248

HIV Center for Clinical and Behavioral Studies at the New York State Psychiatric Institute and Columbia University, New York, New York.

We explored interest in disclosing test results through a smartphone app dedicated to self- and partner testing for HIV/syphilis. Fifty-nine cisgender men and transgender women each participated in an in-person survey and interview. We examined their interests in sharing test results by audience (e. Read More

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Bilateral optic disc swelling resulting from lymphocytic meningitis and posterior uveitis secondary to syphilis.

BMJ Case Rep 2021 May 19;14(5). Epub 2021 May 19.

Acute Medical Unit, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

Idiopathic intracranial hypertension (IIH) is being diagnosed more often in the UK due to the rise in obesity. In fact, patients who present with bilateral optic disc swelling are habitually put on the papilloedema pathway, often without consideration of other diagnoses. We report the case of a middle-aged woman diagnosed with papilloedema and managed as IIH, until, cerebrospinal fluid (CSF) analysis revealed evidence of lymphocytic meningitis secondary to syphilis. Read More

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Spinal arteriovenous malformation in a pediatric patient with a history of congenital syphilis: a case report.

BMC Pediatr 2021 05 19;21(1):242. Epub 2021 May 19.

Department of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USA.

Background: Spinal arteriovenous malformations in children are extremely rare and pose great risk for intraoperative hemorrhage. Congenital syphilis sometimes presents with vascular symptoms, however, there is little published on patients with a history of congenital syphilis presenting with spinal arteriovenous malformations.

Case Presentation: A 15-month-old female with a history of congenital syphilis presented with urinary retention, fever, and subacute onset of paraplegia. Read More

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Factors associated with prematurity in reported cases of congenital syphilis.

Rev Saude Publica 2021 17;55:28. Epub 2021 May 17.

Universidade Federal do Espírito Santo. Departamento de Medicina Social. Vitoria, ES, Brasil.

Objective: To analyze the factors associated with prematurity in reported cases of congenital syphilis in the city of Fortaleza, Ceará, Brazil.

Methods: Cross-sectional study conducted in ten public maternity hospitals in Fortaleza, Ceará, Brazil. A total of 478 reported cases of congenital syphilis were included in 2015, and data were collected from notification forms, from mothers' and babies' medical records and from prenatal cards. Read More

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Brazilian Protocol for Sexually Transmitted Infections, 2020: infections that cause genital ulcers.

Rev Soc Bras Med Trop 2021 17;54(suppl 1):e2020663. Epub 2021 May 17.

Ministério da Saúde, Secretaria de Vigilância em Saúde, Brasília, DF, Brasil.

Infections that cause genital ulcers are one of the themes comprising the Clinical Protocol and Therapeutic Guidelines for Comprehensive Care for People with Sexually Transmitted Infections, published by the Brazilian Ministry of Health in 2020. The Protocol and Guidelines have been developed based on scientific evidence and validated in discussions with specialists. This article addresses clinical genital ulcer syndrome caused by sexually transmitted infections and its most common etiological agents: Treponema pallidum (syphilis), herpes simplex virus-2 (genital herpes) and herpes simplex virus-1 (perioral herpes), Haemophilus ducreyi (chancroid), Chlamydia trachomatis serotypes L1, L2 and L3 (lymphogranuloma venereum), and Klebsiella granulomatis (donovanosis). Read More

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Brazilian Protocol for Sexually Transmitted Infections 2020: syphilis diagnostic tests.

Rev Soc Bras Med Trop 2021 17;54(suppl 1):e2020630. Epub 2021 May 17.

Universidade Federal de Santa Catarina, Laboratório de Biologia Molecular, Microbiologia e Sorologia, Florianópolis, SC, Brasil.

The recommendations for diagnostic tests for investigating syphilis are part of the Clinical Protocol and Therapeutic Guidelines for Comprehensive Care for People with Sexually Transmitted Infections and the Technical Manual for Syphilis Diagnosis, published by the Brazilian Ministry of Health. These recommendations were developed based on scientific evidence and discussions with a panel of experts. This article presents direct tests to detect Treponema pallidum in lesions and algorithms that combine treponemal and non-treponemal antibody tests to assist in syphilis diagnosis, with the aim of contributing to the efforts of health service managers and health professionals in qualifying health care. Read More

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Brazilian Protocol for Sexually Transmitted Infections 2020: acquired syphilis.

Rev Soc Bras Med Trop 2021 17;54(suppl 1):e2020616. Epub 2021 May 17.

Ministério da Saúde, Secretaria de Vigilância em Saúde, Brasilia, DF, Brasil.

The Clinical Protocol and Therapeutic Guidelines for Comprehensive Care of People with Sexually Transmitted Infections, published by the Brazilian Ministry of Health in 2020, includes updates concerning acquired syphilis. The document comprises rapid test use, safety and efficacy of benzathine benzylpenicillin, case follow-up, neurosyphilis clinical and laboratory management, approaching sex partners, assistance and monitoring of diagnosed pregnant women, and syphilis and HIV co-infection specificities, as well as a case notification summary. Health managers and professionals must be continuously trained so as to integrate care and surveillance, to strengthen actions for efficient control of syphilis, to broaden the search for sex partners, and to expand access of most vulnerable populations to health services. Read More

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Brazilian Protocol for Sexually Transmitted Infections, 2020: congenital syphilis and child exposed to syphilis.

Rev Soc Bras Med Trop 2021 17;54(suppl 1):e2020597. Epub 2021 May 17.

Universidade de Pernambuco, Departamento Materno-Infantil, Recife, PE, Brazil.

The topics of congenital syphilis and children exposed to syphilis compose the Clinical Protocol and Therapeutic Guidelines for Comprehensive Care for People with Sexually Transmitted Infections, published by the Brazilian Ministry of Health in 2020. Such document was elaborated based on scientific evidence and validated in discussions with specialists. This article provides guidelines for syphilis in pregnant women and congenital syphilis clinical management, emphasizing the vertical transmission of Treponema pallidum prevention. Read More

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Brazilian Protocol for Sexually Transmitted Infections 2020: epidemiological surveillance.

Rev Soc Bras Med Trop 2021 17;54(suppl 1):e2020549. Epub 2021 May 17.

Secretaria de Estado da Saúde de São Paulo, Centro de Referência e Treinamento de Doenças Sexualmente Transmissíveis e Aids, São Paulo, SP, Brazil.

This article summarizes the chapter on epidemiological surveillance of sexually transmitted infections (STI) that comprises the 2020 Clinical Protocol and Therapeutic Guidelines (PCDT) for Comprehensive Care for People with STI, published by the Health Surveillance Department of the Brazilian Ministry of Health. It presents some reflections on the new case definitions for surveillance of acquired syphilis, syphilis in pregnant women, and congenital syphilis. The 2020 PCDT-IST was elaborated grounded on scientific evidence and validated in discussions with specialists. Read More

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Comparative Analysis of Molecular and Serologic Testing for Primary Syphilis: A Population-Based Cohort Study.

Front Cell Infect Microbiol 2021 23;11:579660. Epub 2021 Apr 23.

Department of Medicine, University of Calgary, Calgary, AB, Canada.

Rising rates of syphilis () requires rapid diagnosis and treatment to manage the growing epidemic. Syphilis serology is imperfect and requires interpretation of multiple tests while molecular diagnostics allows for potential yes-no identification of highly infective, primary anogenital lesions. Accuracy of this testing modality has thus far been limited to small, highly selective studies. Read More

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Text message reminders and peer education increase HIV and Syphilis testing among female sex workers: a pilot quasi-experimental study in Uganda.

BMC Health Serv Res 2021 May 7;21(1):436. Epub 2021 May 7.

School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: Globally, female sex workers (FSW) are disproportionately affected by HIV and other sexually transmitted infections (STIs). However, uptake of STI and HIV testing services among FSW in sub-Saharan Africa remains low. We aimed to assess the effect of FSW-led peer education and text message reminders on 3-monthly syphilis and HIV testing among FSW in Uganda. Read More

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Oyster Shell-Like Skin Lesions in a Young Man.

Mayo Clin Proc 2021 05;96(5):1120-1121

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Skin and Immune Diseases, Beijing, P.R. China. Electronic address:

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Hepatitis B virus prevalence in first-time blood donors in Flanders, Belgium: Impact of universal vaccination and migration.

Transfusion 2021 May 6. Epub 2021 May 6.

Blood Service, Belgian Red Cross, Mechelen, Belgium.

Background: Transfusion-transmissible infections such as hepatitis B virus (HBV) remain a major concern for the safety of blood transfusion. This cross-sectional study aimed to assess the trend of HBV prevalence and associated risk factors among a first-time donor population in a low endemic country.

Study Design And Methods: Between 2010 and 2018, blood samples were collected from first-time donors presented at donor collection sites of Belgian Red Cross-Flanders. Read More

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Diffuse Bilateral Subacute Placoid Chorioretinitis and Hot Optic Disc as Part of Ocular Manifestations of Neurosyphilis: A Case Report.

Klin Monbl Augenheilkd 2021 04 30;238(4):434-436. Epub 2021 Apr 30.

Department of Ophthalmology (Chairman Prof. Dr. med. Ch. Valmaggia), Kantonsspital St Gallen, Sankt Gallen, Switzerland.

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Secondary syphilis mimicking tinea cruris in an HIV infected patient: a case report.

Pan Afr Med J 2021 5;38:133. Epub 2021 Feb 5.

Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Syphilis is known as the great imitator with various clinical presentations which often lead to confusion and misdiagnosis. A 28-year-old male presented with non-pruritic and painless erythematous patches around the anus and scrotum. Initial differential diagnosis with tinea cruris. Read More

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Exploration of an Efficient Simultaneous Molecular Detection Method of HIV, HCV, and Syphilis from a Single Dried Blood Spot.

Biomed Environ Sci 2021 Apr;34(4):257-264

National HIV Reference Laboratory, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Objective: The aim of the present study was to evaluate the performance of the simultaneous detection of HIV-1 RNA, HIV-1 DNA, and HCV RNA using one dried blood spot (DBS) as an alternative sample to plasma.

Method: A total of 571 paired DBS/plasma samples were collected from men who have sex with men (MSM) and injection drug users (IDUs), and serological and molecular assays were performed. Using plasma results as the reference standard, the performance of DBS tests for HIV-1 RNA, HIV-1 DNA, and HCV RNA was evaluated. Read More

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Prevalence assessment of sexually transmitted infections among pregnant women visiting an antenatal care center of Nepal: Pilot of the World Health Organization's standard protocol for conducting STI prevalence surveys among pregnant women.

PLoS One 2021 23;16(4):e0250361. Epub 2021 Apr 23.

Department of Global Programmes of HIV, Hepatitis, STI, World Health Organization, Geneva, Switzerland.

Introduction: Sexually transmitted infections (STIs) are common during pregnancy and can result in adverse delivery and birth outcomes. The purpose of this study was to estimate the prevalence of STIs; Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Treponema pallidum (syphilis), Trichomonas vaginalis (trichomoniasis), and Human Immunodeficiency Virus (HIV) among pregnant women visiting an antenatal care center in Nepal.

Materials And Methods: We adapted and piloted the WHO standard protocol for conducting a prevalence survey of STIs among pregnant women visiting antenatal care center of Dhulikhel Hospital, Nepal. Read More

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An unusual presentation of neuro-ophthalmic syphilis.

Intern Med J 2021 Apr;51(4):610-612

Princess Alexandra Hospital, Brisbane, Queensland, Australia.

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Prevalence of sexually transmitted infections among cervical cancer suspected women at University of Gondar Comprehensive Specialized Hospital, North-west Ethiopia.

BMC Infect Dis 2021 Apr 23;21(1):378. Epub 2021 Apr 23.

Department of Medical Microbiology, College of Medicine and Health Sciences, School of Biomedical and Laboratory Sciences, University of Gondar, P.O. Box: 196, Gondar, Ethiopia.

Background: Sexually transmitted infections (STIs) such as Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and Syphilis have continued a significant public health problem, especially in areas with substandard infection prevention and control programs. It is known that STIs are largely associated with the increased occurrence of cervical cancer. To date, little is known about the burden of STIs among cervical cancer suspected women in Ethiopia. Read More

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