29,417 results match your criteria Endemic Syphilis


Investigation of syphilis immunology and Treponema pallidum subsp. pallidum biology to improve clinical management and design a broadly protective vaccine: study protocol.

BMC Infect Dis 2020 Jun 23;20(1):444. Epub 2020 Jun 23.

Division of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.

Background: The syphilis epidemic continues to cause substantial morbidity and mortality worldwide, particularly in low- and middle-income countries, despite several recent disease control initiatives. Though our understanding of the pathogenesis of this disease and the biology of the syphilis agent, Treponema pallidum subsp. pallidum has improved over the last two decades, further research is necessary to improve clinical diagnosis and disease management protocols. Read More

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http://dx.doi.org/10.1186/s12879-020-05141-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309211PMC

Syphilis in an Italian medieval jewish community: A bioarchaeological and cultural perspective.

Int J Paleopathol 2020 Jun 19;30:85-97. Epub 2020 Jun 19.

Dept. of Biological, Geological and Environmental Sciences, Alma Mater Studiorum-University of Bologna, Bologna, Italy.

Objectives: We aim to discuss the presence of treponemal infections in three individuals belonging to a large (∼400 individuals) Late Medieval cemetery (14th -16th century) that archaeological and documentary sources place within a Jewish context, and to discuss the role of these diseases in a biocultural perspective.

Materials And Methods: An anthropological and paleopathological study was conducted on skeletal remains of three individuals, though macroscopic and tomographic examination.

Results: Cranial lesions in which simultaneous destructive and proliferative processes (caries sicca) are noted. Read More

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http://dx.doi.org/10.1016/j.ijpp.2020.06.001DOI Listing

Performance of Treponema pallidum recombinant proteins in the serological diagnosis of syphilis.

PLoS One 2020 18;15(6):e0234043. Epub 2020 Jun 18.

Gonçalo Moniz Institute, Oswaldo Cruz Foundation (Fiocruz-BA), Salvador, Bahia, Brazil.

Syphilis serodiagnosis is challenging because distinct clinical forms of the infection may influence serological performance and discordant results between tests make clinical decisions difficult. Several recombinant Treponema pallidum-proteins have already been tested for syphilis diagnosis and they are critical to achieve high accuracy in serological testing. Our aim was to assess the varied from performance of T. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234043PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302711PMC

High lifetime prevalence of syphilis in men who have sex with men and transgender women versus low lifetime prevalence in female sex workers in Lima, Peru.

Sex Transm Dis 2020 Jun 11. Epub 2020 Jun 11.

Division of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, CA, USA.

Background: The syphilis epidemic continues to cause substantial morbidity worldwide and is worsening despite ongoing control efforts. Syphilis remains an important public health problem among three key populations: men who have sex with men (MSM), transgender women, and female sex workers.

Methods: We conducted a retrospective chart review of patients that received rapid point-of-care treponemal antibody tests from January 2019-July 2019 in four STI clinics in Lima, Peru. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001200DOI Listing

Ocular syphilis in an immunocompetent man.

IDCases 2020 25;21:e00840. Epub 2020 May 25.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

A healthy 47-year-old immunocompetent man from Northern Canada presented for ophthalmologic assessment after experiencing one month of right-sided photopsias, floaters, and a right lower nasal quadrant visual field defect. Optic disc swelling, vitritis, chorioretinitis, peripheral retinal infiltrates and hemorrhages were noted in the right eye. A broad right inferior arcuate and nasal visual field defect were also present. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283143PMC

Phase II trial evaluating the clinical efficacy of cefixime for treatment of active syphilis in non-pregnant women in Brazil (CeBra).

BMC Infect Dis 2020 Jun 10;20(1):405. Epub 2020 Jun 10.

Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.

Background: Syphilis is a sexually and vertically transmitted infection caused by the bacteria Treponema pallidum for which there are few proven alternatives to penicillin for treatment. For pregnant women infected with syphilis, penicillin is the only WHO-recommended treatment that will treat the mother and cross the placenta to treat the unborn infant and prevent congenital syphilis. Recent shortages, national level stockouts as well as other barriers to penicillin use call for the urgent identification of alternative therapies to treat pregnant women infected with syphilis. Read More

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http://dx.doi.org/10.1186/s12879-020-04980-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288542PMC

The Modern Epidemic of Syphilis. Reply.

N Engl J Med 2020 06;382(24):2380

University of Massachusetts Medical Center, Worcester, MA

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http://dx.doi.org/10.1056/NEJMc2006129DOI Listing
June 2020
55.873 Impact Factor

The Modern Epidemic of Syphilis.

N Engl J Med 2020 06;382(24):2379-2380

University Hospital Schleswig-Holstein Campus Lübeck, Lübeck, Germany

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http://dx.doi.org/10.1056/NEJMc2006129DOI Listing

The Modern Epidemic of Syphilis.

N Engl J Med 2020 06;382(24):2379

Japanese Red Cross Society, Tokyo, Japan.

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http://dx.doi.org/10.1056/NEJMc2006129DOI Listing

Missed Opportunities for Prevention of Congenital Syphilis - United States, 2018.

MMWR Morb Mortal Wkly Rep 2020 Jun 5;69(22):661-665. Epub 2020 Jun 5.

Congenital syphilis is an infection with Treponema pallidum in an infant or fetus, acquired during pregnancy from a mother with untreated or inadequately treated syphilis. Congenital syphilis can cause miscarriage, stillbirth, or early infant death, and infected infants can experience lifelong physical and neurologic problems. Although timely identification and treatment of maternal syphilis during pregnancy can prevent congenital syphilis (1,2), the number of reported congenital syphilis cases in the United States increased 261% during 2013-2018, from 362 to 1,306. Read More

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http://dx.doi.org/10.15585/mmwr.mm6922a1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272112PMC

Comparison of coronary artery bypass grafting and percutaneous coronary intervention for syphilitic coronary artery ostial lesions: A 4-year retrospective study.

Medicine (Baltimore) 2020 May;99(21):e20104

Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, Fujian, China.

This study investigated the efficacy of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in treatment of patients with syphilitic coronary artery ostial lesions (SCAOL).Sixty SCAOL patients were divided into two groups according to the different treatments: the CABG group (n = 32) and the PCI group (n = 28). We determined serum levels of β-type natriuretic peptide (BNP) and cardiac function, and evaluated treatment efficacy such as the rates of restenosis, patency, and major adverse cardiovascular events (MACEs) during hospital stay and the effects of antisyphilis and different types of CABG on restenosis during the 6-month follow-up period. Read More

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http://dx.doi.org/10.1097/MD.0000000000020104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249995PMC
May 2020
5.723 Impact Factor

High prevalence of syphilis in a female prison unit in Northeastern Brazil.

Einstein (Sao Paulo) 2020 15;18:eAO4978. Epub 2020 May 15.

Universidade Federal de Pernambuco, Recife, PE, Brazil.

Objective To determine the prevalence of syphilis and the associated risk factors in a female prison unit. Methods This was a cross-sectional study including 113 women whom data were collected in two stages: first, blood test to check for syphilis seropositivity; and then collection of information through a form to assess risk situations for sexually transmitted infections. Results Overall, syphilis prevalence was found to be 22. Read More

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http://dx.doi.org/10.31744/einstein_journal/2020ao4978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206982PMC

Ocular syphilis in Pacific peoples-are we making misdiagnoses secondary to yaws?

N Z Med J 2020 04 24;133(1513):53-60. Epub 2020 Apr 24.

Department of Ophthalmology, Auckland District Health Board, Auckland; Department of Ophthalmology, University of Auckland, Auckland.

Aims: To determine the demographic and clinical features of patients with ocular disease consistent with syphilis and positive treponemal serology in Auckland, and to compare patients who lived in a Pacific nation before 1960 with all other patients with regard to these features, considering a possible history of yaws infection.

Methods: Retrospective review of subjects seen in uveitis and neuroophthalmology clinics at Auckland District Health Board between January 2006 and June 2019.

Results: Two thousand four hundred and ninety-three subjects were reviewed in uveitis clinics during the timeframe, of whom 45 were diagnosed with syphilitic uveitis (1. Read More

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Infectious Proctitis.

N Engl J Med 2020 Apr;382(17):1638

Griffin Hospital, Derby, CT

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http://dx.doi.org/10.1056/NEJMicm1906077DOI Listing

[Trend of Syphilis Infection among Voluntary Blood Donors in Foshan City from 2008 to 2017].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Apr;28(2):641-645

Foshan Central Blood Station, Foshan 528000, Guangdong Province, China.

Objective: To investigate the prevalence of syphilis infection in voluntary blood donors in Foshan City, so as to provide reference for improving the infusion blood safety strategy of city.

Methods: A total of 657 382 voluntary blood donors in Foshan City from January 2008 to December 2017 were selected. The blood samples were tested for treponema pallidum. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.02.047DOI Listing

[Health status and healthcare service utilization among children born to women with maternal syphilis in Shanghai].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 Mar;41(3):337-342

Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China; Key Lab of Health Technology Assessment, National Health Commission, Fudan University Shanghai 200032, China.

To assess the health status and health service utilization of children born to syphilis infected mothers during pregnancy, in order to prevent mother-to-child transmission of syphilis to the newborns. Women with maternal syphilis were studied by trained researchers via phone calls, in Shanghai during 2014-2015. Data related to demographics, status of infection and health care, utilization by both mothers and their children were collected through specifically designed questionnaires. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2020.03.011DOI Listing

Reply to: "COVID-19, syphilis, and biologic therapies for psoriasis and psoriatic arthritis: A word of caution".

J Am Acad Dermatol 2020 06 10;82(6):e215. Epub 2020 Apr 10.

Department of Dermatology, St. George Hospital, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1016/j.jaad.2020.03.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151396PMC

Evaluating coverage of maternal syphilis screening and treatment within antenatal care to guide service improvements for prevention of congenital syphilis in 2030 Countries.

J Glob Health 2020 Jun;10(1):010504

World Health Organization, Geneva, Switzerland.

Background: Countdown to 2030 (CD2030) tracks progress in the 81 countries that account for more than 90% of under-five child deaths and 95% of maternal deaths in the world. In 2017, CD2030 identified syphilis screening and treatment during antenatal care (ANC) as priority indicators for monitoring.

Methods: Country-reported data in the UNAIDS Global AIDS Monitoring System (GAM) system were used to evaluate four key syphilis indicators from CD2030 countries: (1) maternal syphilis screening and (2) treatment coverage during ANC, (3) syphilis seroprevalence among ANC attendees, and (4) national congenital syphilis (CS) case rates. Read More

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http://dx.doi.org/10.7189/jogh.10.010504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138526PMC

Husband's willingness-to-pay for HIV and syphilis screening at antenatal care clinic under the Thai universal coverage scheme.

BMC Public Health 2020 Apr 10;20(1):480. Epub 2020 Apr 10.

Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Screening for sexually transmitted infection (STI) especially HIV as early detection and treatment have been financially supported under the Thai Universal Coverage (UC) scheme since 2009 (THB140 for HIV). However, the implementation has not been evidence-based, strategic risk-based, nor economically evaluated whereas husbands who accompanied the pregnant women are likely to have a lower risk than those who did not come along. This study is aimed to determine the husband's willingness-to-pay (WTP) for his HIV and syphilis screening tests and potential factors affecting STI screenings at the antenatal care (ANC) clinic of a tertiary hospital in Thailand. Read More

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http://dx.doi.org/10.1186/s12889-020-08613-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149847PMC

Trends of syphilis in Brazil: A growth portrait of the treponemic epidemic.

PLoS One 2020 9;15(4):e0231029. Epub 2020 Apr 9.

Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

Syphilis is a chronic infectious disease with its prevalence being described since the 15th century. Although its etiological agent and also the treatment measures are widely known, syphilis is still a great public health problem worldwide, mainly in countries with limited resources associated to low investments in health primary care. The aim of the present study was to analyze the trend and regional distribution of syphilis in Brazil between 2007 and 2017. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231029PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145144PMC

Multidrug-resistant HIV viral rebound during early syphilis: a case report.

BMC Infect Dis 2020 Apr 7;20(1):273. Epub 2020 Apr 7.

III Infectious Disease Unit, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy.

Background: Syphilis has been associated with an increase in HIV RNA and a temporary decline in CD4 T cell counts in people living with HIV who are not receiving antiretroviral treatment (ART), and may be associated with a transient HIV RNA rebound in those who are receiving ART. Our case is the first to highlight the risk of a multidrug-resistant HIV viral rebound during the course of early syphilis even if antiretroviral drug concentrations are within the therapeutic range.

Case Presentation: This 50-year-old HIV-1-positive male patient with concomitant early syphilis presented with an HIV RNA rebound (8908 copies/mL) during a scheduled visit to our clinic. Read More

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http://dx.doi.org/10.1186/s12879-020-04999-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140389PMC

Comparative genomics and full-length Tprk profiling of Treponema pallidum subsp. pallidum reinfection.

PLoS Negl Trop Dis 2020 04 6;14(4):e0007921. Epub 2020 Apr 6.

Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America.

Developing a vaccine against Treponema pallidum subspecies pallidum, the causative agent of syphilis, remains a public health priority. Syphilis vaccine design efforts have been complicated by lack of an in vitro T. pallidum culture system, prolific antigenic variation in outer membrane protein TprK, and lack of functional annotation for nearly half of the genes. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162541PMC

COVID-19, syphilis, and biologic therapies for psoriasis and psoriatic arthritis: A word of caution.

J Am Acad Dermatol 2020 06 1;82(6):e213. Epub 2020 Apr 1.

Department of Dermatology, Venereology, and Leprosy, All India Institute of Medical Sciences, Rishikesh. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.03.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118699PMC

Enzyme-linked immunosorbent assay (ELISA) versus Venereal Disease Research Laboratory test (VDRL) and rapid plasma reagin test (RPR) for screening of syphilis in pregnant women.

Int J Gynaecol Obstet 2020 Jul 23;150(1):103-107. Epub 2020 Apr 23.

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.

Objective: To evaluate a treponemal enzyme-linked immunosorbent assay (ELISA) as an alternative screening test for syphilis in pregnant women.

Methods: A cross-sectional study of diagnostic test accuracy was carried out in a large volume laboratory from a tertiary care center. A total of 416 serum samples, including 102 archived syphilis Treponema pallidum hemagglutination (TPHA)-positive samples and 314 samples from pregnant women, were used to determine the sensitivity and specificity of ELISA. Read More

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http://dx.doi.org/10.1002/ijgo.13154DOI Listing

A patient with anti-NXP2-positive dermatomyositis and syphilis.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Department of Dermatology, University of California Davis, Sacramento, CA.

Dermatomyositis is an auto-immune inflammatory myopathy that primarily affects the skin and muscle and can be triggered by exposure to various environmental factors. We present a patient with active syphilis infection who developed dermatomyositis and discuss the significance of anti-NXP2 autoantibody positivity. Read More

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February 2020

[Sexually transmitted infections: gonococcal disease, chlamydia, syphilis, human papillomavirus, trichomonas].

Rev Prat 2019 Dec;69(10):e337-e350

Service de maladie infectieuse-dermatologie (CeGIDD), CHU de La Réunion site Sud, La Réunion, France.

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December 2019

Secondary syphilis presenting as Syphilide psoriasiforme: lessons from the older syphilology literature.

Rev Inst Med Trop Sao Paulo 2020 30;62:e21. Epub 2020 Mar 30.

Universidade Federal do Estado do Rio de Janeiro, Hospital Universitário Gaffrée e Guinle, Centro de Ciências Biológicas e da Saúde, Rio de Janeiro, Rio de Janeiro, Brazil.

It is essential for health care providers to be familiared with the full spectrum of clinical presentations of syphilis. We present herein a case of syphilide psoriasiforme, an uncommon but well recognized clinical presentation of secondary syphilis. A 46-year-old HIV-infected female patient was referred to our attention with a presumptive diagnosis of palmoplantar psoriasis. Read More

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http://dx.doi.org/10.1590/S1678-9946202062021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178809PMC

Syphilis and HIV infection in indigenous Mbya Guarani communities of Puerto Iguazu (Argentina): diagnosis, contact tracking, and follow-up.

Rev Inst Med Trop Sao Paulo 2020 30;62:e19. Epub 2020 Mar 30.

Universidad Miguel Hernández de Elche, Departamento de Medicina Clínica, Alicante, Spain.

The aim of study was to assess the prevalence of Treponema pallidum and HIV infection in Amerindian people (Mbya Guarani) over the age of 11 in Puerto Iguazu (Argentina) and to describe the contact tracking of cases. The method was a cross-sectional study in the Mbya Guarani people living in three villages of Puerto Iguazu (community A, pop. 1,146; community B, pop. Read More

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http://dx.doi.org/10.1590/S1678-9946202062019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178811PMC

Whole genome sequence of the Treponema pallidum subsp. endemicum strain Iraq B: A subpopulation of bejel treponemes contains full-length tprF and tprG genes similar to those present in T. p. subsp. pertenue strains.

PLoS One 2020 1;15(4):e0230926. Epub 2020 Apr 1.

Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). Until now, only a single TEN strain, Bosnia A, has been completely sequenced. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230926PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112178PMC

Eyes As the Window to Syphilis: A Rare Case of Ocular Syphilis As the Initial Presentation of Syphilis.

Cureus 2020 Feb 14;12(2):e6998. Epub 2020 Feb 14.

Internal Medicine, Upstate Medical University, Syracuse, USA.

In the pre-antibiotic era, neurosyphilis (NS) was common, occurring in 34% of patients with syphilis. Currently, there has been a rising trend in syphilis with HIV-infected patients being more prone to develop NS. Ocular involvement is very rare in NS and accounts for only 1%-5% of the cases in the United States. Read More

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http://dx.doi.org/10.7759/cureus.6998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077063PMC
February 2020

Painful penile ulcers and testicular pain in a 45-year-old HIV-positive man.

Nurse Pract 2020 04;45(4):14-17

Patrick O'Byrne is an associate professor at the University of Ottawa, School of Nursing, Ontario, Canada and an NP at Ottawa Public Health Sexual Health Clinic, Ontario, Canada. He also holds a research chair in public health & HIV prevention from the Ontario HIV Treatment Network (OHTN), Government of Ontario, Canada. Paul A. MacPherson is an associate professor of Medicine at the University of Ottawa, Faculty of Medicine, Ontario, Canada and an infectious diseases specialist at The Ottawa Hospital, Division of Infectious Diseases, Ontario, Canada.

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http://dx.doi.org/10.1097/01.NPR.0000657340.39903.52DOI Listing

Acquired syphilis in children: A widely neglected public health issue.

Authors:
Fu-Quan Long

Pediatr Dermatol 2020 03;37(2):316

Department of Sexually Transmitted Diseases, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1111/pde.14114DOI Listing

Syphilis testing performance: continuous quality improvement (CQI) works for some but not for all.

Aust N Z J Public Health 2020 Apr 19;44(2):169-170. Epub 2020 Mar 19.

Nulungu Research Institute, University of Notre Dame Australia, Western Australia.

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http://dx.doi.org/10.1111/1753-6405.12973DOI Listing

Neurosyphilis vasculitis manifesting as ischemic stroke.

Rev Soc Bras Med Trop 2020;53:e20190546. Epub 2020 Mar 16.

Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Radiologia, Campinas, SP, Brasil.

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http://dx.doi.org/10.1590/0037-8682-0546-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094051PMC

HIV Testing Among Adolescents With Acute Sexually Transmitted Infections.

Pediatrics 2020 04 16;145(4). Epub 2020 Mar 16.

Craig Dalsimer Division of Adolescent Medicine and.

Background And Objectives: Rates of sexually transmitted infections (STIs) have increased over the decade. Guidelines recommend HIV testing with incident STIs. Prevalence and factors associated with HIV testing in acute STIs are unknown in adolescents. Read More

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http://dx.doi.org/10.1542/peds.2019-2265DOI Listing

Factors associated with cutaneous ulcers among children in two yaws-endemic districts in Ghana.

Infect Dis Poverty 2020 Mar 12;9(1):26. Epub 2020 Mar 12.

Public Health Unit, Komfo-Anokye Teaching Hospital, Kumasi, Ghana.

Background: Yaws is a chronic relapsing disease caused by Treponema pallidum subspecies pertunue, which can result in severe disability and deformities. Children below the age of 15 years in resource-poor communities are the most affected. Several non-specific factors facilitate the continuous transmission and resurgence of the disease. Read More

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http://dx.doi.org/10.1186/s40249-020-00641-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066816PMC

No bejel among Surinamese, Antillean and Dutch syphilis diagnosed patients in Amsterdam between 2006-2018 evidenced by multi-locus sequence typing of Treponema pallidum isolates.

PLoS One 2020 11;15(3):e0230288. Epub 2020 Mar 11.

Department of Biology, Masaryk University, Brno, Czech Republic.

Background: Treponema pallidum subspecies pallidum (TPA) and subsp. endemicum (TEN) are the causative agents of syphilis and bejel, respectively. TEN shows similar clinical manifestations and is morphologically and serologically indistinguishable from TPA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230288PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065763PMC

[Сomparison of immunoarrays for syphilis diagnostics produced by co-polymerization immobilization and non-contact printing techniques.]

Klin Lab Diagn 2020 ;65(1):16-23

State Research Center of Dermatovenereology and Cosmetology, 107076, Moscow, Russia.

The aim of the study was to investigate the characteristics of immunoarrays (microarrays) produced by co-polymerization immobilization and non-contact printing techniques for enhancing the capacities of syphilis diagnostics. In diagnostic context immunoarrays of both protein immobilization techniques have shown high sensitivity and specificity together with potency to differentiate syphilis stages in serologic assays. The article discloses the advantages and limitations of non-contact printing techniques as well as the results and problems revealed in the study. Read More

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http://dx.doi.org/10.18821/0869-2084-2020-65-1-16-23DOI Listing

Non-performance of serological tests for syphilis during prenatal care: prevalence and associated factors.

Rev Bras Epidemiol 2020 21;23:e200012. Epub 2020 Feb 21.

Programa de Pós-graduação em Saúde Pública, Faculdade de Medicina, Universidade Federal do Rio Grande - Rio Grande (RS), Brasil.

Introduction: Syphilis is a sexually transmitted disease, easy to diagnose and treat, but whose incidence is increasing in Brazil. This study estimated the prevalence of the non-performance of serological tests for syphilis during prenatal care, in addition to evaluating its trend and identifying its associated factors in the municipality of Rio Grande, Rio Grande do Sul, Southern Brazil.

Methods: This is a cross-sectional survey that included all pregnant women living in this municipality who gave birth between January 1 and December 31, 2007, 2010, and 2013. Read More

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http://dx.doi.org/10.1590/1980-549720200012DOI Listing

The Modern Epidemic of Syphilis.

N Engl J Med 2020 02;382(9):845-854

From the Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore (K.G.G.); and the Department of Medicine and Division of Infectious Diseases and Immunology, University of Massachusetts Medical Center, Worcester (S.R., P.A.R.).

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http://dx.doi.org/10.1056/NEJMra1901593DOI Listing
February 2020
55.873 Impact Factor

Congenital syphilis in Mexico. Analysis of national and international standards from the perspective of laboratory diagnosis.

Gac Med Mex 2019 ;155(5):430-438

Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.

Introduction: Congenital syphilis continues to be a public health problem in Mexico.

Objective: To assess the similarities and differences between national standards, guidelines and international documents related to the detection of syphilis in pregnant women and congenital syphilis.

Method: Two algorithms were developed based on the standard of female care during pregnancy and on the standard for prevention and control of sexually transmitted infections. Read More

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http://dx.doi.org/10.24875/GMM.M20000328DOI Listing

MicroRNA expression profiling of peripheral blood mononuclear cells associated with syphilis.

BMC Infect Dis 2020 Feb 22;20(1):165. Epub 2020 Feb 22.

Dermatology Hospital, Southern Medical University, Guangzhou, China.

Background: Treponema pallidum (T. pallidum) infection evokes significant immune responses, resulting in tissue damage. The immune mechanism underlying T. Read More

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http://dx.doi.org/10.1186/s12879-020-4846-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036247PMC
February 2020

Authors' reply to Shaffer and colleagues.

BMJ 2020 02 19;368:m564. Epub 2020 Feb 19.

Unicef Office of Research, Innocenti, Florence, Italy.

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http://dx.doi.org/10.1136/bmj.m564DOI Listing
February 2020

Prevalence of syphilis in female sex workers in three countryside cities of the state of Pará, Brazilian Amazon.

BMC Infect Dis 2020 Feb 11;20(1):129. Epub 2020 Feb 11.

Virology Laboratory, Institute of Biological Sciences, Federal University of Pará, Brazil. Augusto Correa 1. Guamá. CEP 66075-110, Belém, Pará, Brazil.

Background: Syphilis is a sexually transmitted infection (STI) transmitted from person to person mainly by sexual intercourse or through vertical transmission during pregnancy. Female sex workers (FSWs) are exposed especially to syphilis infection, and besides all the efforts to control the spread of STIs, syphilis prevalence is still rising, mainly occurring in low-income countries. This study aimed to investigate the syphilis prevalence, demographic characteristics and sexual habits among FSWs in the Amazon region of Brazil. Read More

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http://dx.doi.org/10.1186/s12879-020-4850-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014696PMC
February 2020

[Classical sexually transmitted diseases in the anorectal region].

Hautarzt 2020 Apr;71(4):275-283

Klinik für Dermatologie und Venerologie, Universitätsklinikum Essen, Essen, Deutschland.

Background: Sexually transmitted infections (STIs) in the anorectal region are disproportionally detected in risk populations such as men who have sex with men (MSM). However, due to changes in sexual behaviour they are increasingly diagnosed in heterosexual individuals. Due to the recent implementation of oral HIV pre-exposure prophylaxis together with lack of condom use, a further rise in STIs is expected. Read More

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http://dx.doi.org/10.1007/s00105-020-04547-wDOI Listing

Disabling complications of primary syphilis in a 34-year-old woman living with HIV.

Int J STD AIDS 2020 03 5;31(3):274-275. Epub 2020 Feb 5.

Institute of clinical medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

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http://dx.doi.org/10.1177/0956462419888312DOI Listing

Yaws in the Philippines: first reported cases since the 1970s.

Infect Dis Poverty 2020 Jan 30;9(1). Epub 2020 Jan 30.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Yaws is a chronic, highly contagious skin and bone infection affecting children living in impoverished, remote communities and caused by Treponema pallidum subspecies pertenue. The Philippines was thought to be free of yaws following the 1950s eradication campaign but it has been reported in the Liguasan Marsh area, Central Mindanao. This is the first documentation of yaws cases in the Philippines since the 1970s. Read More

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http://dx.doi.org/10.1186/s40249-019-0617-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990502PMC
January 2020

Sexually transmitted infections and sexual behaviors of men who have sex with men in an American Deep South PrEP clinic.

Int J STD AIDS 2020 02 28;31(2):127-135. Epub 2020 Jan 28.

Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1177/0956462419886228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275373PMC
February 2020