Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study.
- Iêda M Orioli,
- Helen Dolk,
- Jorge S Lopez-Camelo,
- Daniel Mattos,
- Fernando A Poletta,
- Maria G Dutra,
- Flavia M Carvalho,
- Eduardo E Castilla
BMJ 2017 Nov 21;359:j5018. Epub 2017 Nov 21.
National Institute of Population Medical Genetics (INAGEMP), Porto Alegre, Brazil.
Objective To describe the prevalence and clinical spectrum of microcephaly in South America for the period 2005-14, before the start of the Zika epidemic in 2015, as a baseline for future surveillance as the Zika epidemic spreads and as other infectious causes may emerge in future.Design Prevalence and case-control study.Data sources ECLAMC (Latin American Collaborative Study of Congenital Malformations) database derived from 107 hospitals in 10 South American countries, 2005 to 2014. Read More