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    Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study.
    BMJ 2017 Nov 21;359:j5018. Epub 2017 Nov 21.
    National Institute of Population Medical Genetics (INAGEMP), Porto Alegre, Brazil.
    Objective To describe the prevalence and clinical spectrum of microcephaly in South America for the period 2005-14, before the start of the Zika epidemic in 2015, as a baseline for future surveillance as the Zika epidemic spreads and as other infectious causes may emerge in future.Design Prevalence and case-control study.Data sources ECLAMC (Latin American Collaborative Study of Congenital Malformations) database derived from 107 hospitals in 10 South American countries, 2005 to 2014. Read More

    Chemical composition and insecticidal activity of the essential oil from Helichrysum faradifani endemic to Madagascar.
    Nat Prod Res 2017 Nov 3:1-9. Epub 2017 Nov 3.
    f School of Pharmacy , University of Camerino , Camerino , Italy.
    Helichrysum faradifani (Asteraceae) is a perennial shrub growing in rocky and sandy places of Madagascar. The plant is used in the Malagasy traditional medicine as a wound-healing agent, disinfectant and for the treatment of syphilis, diarrhea, cough and headache. In the present work, we analysed the chemical composition of the essential oil distilled from the aerial parts of H. Read More

    The cost and cost-effectiveness of rapid testing strategies for yaws diagnosis and surveillance.
    PLoS Negl Trop Dis 2017 Oct 26;11(10):e0005985. Epub 2017 Oct 26.
    Unit of General Epidemiology and Disease Control, Institute of Tropical Medicine, Antwerp, Belgium.
    Background: Yaws is a non-venereal treponemal infection caused by Treponema pallidum subspecies pertenue. The disease is targeted by WHO for eradication by 2020. Rapid diagnostic tests (RDTs) are envisaged for confirmation of clinical cases during treatment campaigns and for certification of the interruption of transmission. Read More

    Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: A retrospective case study.
    Medicine (Baltimore) 2017 Oct;96(43):e8376
    aDepartment of Ophthalmology, The Affiliated Guangren Hospital of Xi'an Jiaotong University College of Medicine bDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
    Syphilitic chorioretinitis should be included in differential diagnosis of any form of ocular inflammation. A significantly higher proportion of human immunodeficiency virus (HIV)-positive patients with ocular syphilis as compared to HIV-negative cases have been reported in published studies. However, the clinical signs and symptoms are more insidious in HIV-negative patients who are easily misdiagnosed. Read More

    Screening for HIV, hepatitis B and syphilis on dried blood spots: A promising method to better reach hidden high-risk populations with self-collected sampling.
    PLoS One 2017 20;12(10):e0186722. Epub 2017 Oct 20.
    Department of Medical Microbiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
    Introduction: Many people at high risk for sexually transmitted infections (STIs), e.g., men who have sex with men (MSM), are not optimally reached by current sexual health care systems with testing. Read More

    Sclerokeratouveitis and lens dislocation in a patient with genital ulcer: was the great imitator imitated?
    BMJ Case Rep 2017 Oct 4;2017. Epub 2017 Oct 4.
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
    Uveitis is the most common ocular manifestation of syphilis, while scleritis is rare. A case of nodular scleritis, peripheral keratitis and uveitis in a patient with genital ulcer is presented in this report. This patient had a clinical profile suggestive of syphilis, though the serology was negative for treponemal antibodies. Read More

    A Smartphone Application to Reduce Time-to-Notification of Sexually Transmitted Infections.
    Am J Public Health 2017 Nov 21;107(11):1795-1800. Epub 2017 Sep 21.
    Adam Carl Cohen is with the Public Health Division, AIDS Healthcare Foundation, Los Angeles, CA. Frederick Zimmerman is with the Department of Health Policy and Management, University of California, Los Angeles (UCLA) Fielding School of Public Health. Michael Prelip and Deborah Glik are with the Department of Community Health Sciences, UCLA Fielding School of Public Health.
    Objectives: To measure whether the implementation of Healthvana-an online patient engagement platform and smartphone application-reduced the number of days between sexually transmitted infection (STI) testing, notification, and treatment at AIDS Healthcare Foundation (AHF) Wellness Centers.

    Methods: We analyzed the retrospective data for 917 male clients who tested positive and received treatment for chlamydia, gonorrhea, or syphilis between January 1, 2014, and December 31, 2015. We included 8 AHF Wellness Centers from California and Florida in the study. Read More

    Aberrant Humoral Immune Responses in Neurosyphilis: CXCL13/CXCR5 Play a Pivotal Role for B-Cell Recruitment to the Cerebrospinal Fluid.
    J Infect Dis 2017 Sep;216(5):534-544
    Shanghai Skin Disease Hospital, Clinical School of Anhui Medical University.
    Background: Previous studies documented that humoral immune responses participated in neurological damage in neurosyphilis patients. However, the mechanisms that trigger and maintain humoral immunity involved in neurosyphilis remain unknown.

    Methods: Using flow cytometry, expression of B cells was measured in neurosyphilis and non-neurosyphilis. Read More

    Spectrum of infectious diseases among newly arrived Eritrean refugees in Switzerland: a cross-sectional study.
    Int J Public Health 2017 Sep 19. Epub 2017 Sep 19.
    Swiss Tropical and Public Health Institute, CH-4002, Basel, Switzerland.
    Objectives: Our study aimed at determining the prevalence of selected infectious diseases among recently arrived Eritrean refugees in Switzerland.

    Methods: In this cross-sectional study, asymptomatic Eritrean migrants aged ≥16 years who arrived <24 months ago were recruited at refugee centres in Switzerland. Infectious disease screening included serology for HIV, hepatitis B and C, syphilis and schistosomiasis, polymerase chain reaction (PCR) for malaria, stool microscopy for helminths and intestinal protozoa and circulating cathodic antigen (CCA) testing in urine for schistosomiasis. Read More

    Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Ghana, Africa: Identical genome sequences in samples isolated more than 7 years apart.
    PLoS Negl Trop Dis 2017 Sep 8;11(9):e0005894. Epub 2017 Sep 8.
    Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno, Czech Republic.
    Background: Treponema pallidum subsp. pertenue (TPE) is the causative agent of yaws, a multi-stage disease, endemic in tropical regions of Africa, Asia, Oceania, and South America. To date, four TPE strains have been completely sequenced including three TPE strains of human origin (Samoa D, CDC-2, and Gauthier) and one TPE strain (Fribourg-Blanc) isolated from a baboon. Read More

    Neurosyphilis in Africa: A systematic review.
    PLoS Negl Trop Dis 2017 Aug 31;11(8):e0005880. Epub 2017 Aug 31.
    Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
    Introduction: Neurological involvement is one of the most important clinical manifestations of syphilis and neurological disease occurs in both early and late syphilis. The impact of HIV co-infection on clinical neurosyphilis remains unclear. The highest prevalence of both syphilis and HIV is in Africa. Read More

    The current status of syphilis prevention and control in Jiangsu province, China: A cross-sectional study.
    PLoS One 2017 24;12(8):e0183409. Epub 2017 Aug 24.
    Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
    Objective: To analyze the midterm evaluation data from the National Syphilis Prevention and Control Plan (2010-2020) and evaluate the current status of syphilis prevention and control in Jiangsu province, China.

    Methods: We collected data via (1) field surveys conducted in 2015 and (2) data recorded in existing syphilis surveillance systems. We conducted descriptive statistical analysis to evaluate the current landscape of syphilis control initiatives and their potential effect in syphilis control. Read More

    The prevalence and incidence of active syphilis in women in Morocco, 1995-2016: Model-based estimation and implications for STI surveillance.
    PLoS One 2017 24;12(8):e0181498. Epub 2017 Aug 24.
    Avenir Health, Glastonbury, Connecticut, United States of America.
    Background: Evolving health priorities and resource constraints mean that countries require data on trends in sexually transmitted infections (STI) burden, to inform program planning and resource allocation. We applied the Spectrum STI estimation tool to estimate the prevalence and incidence of active syphilis in adult women in Morocco over 1995 to 2016. The results from the analysis are being used to inform Morocco's national HIV/STI strategy, target setting and program evaluation. Read More

    Risk factors for syphilis in women: case-control study.
    Rev Saude Publica 2017 Aug 17;51:78. Epub 2017 Aug 17.
    Departamento de Medicina Tropical. Universidade Federal de Pernambuco. Recife, PE, Brasil.
    Objective: To determine the sociodemographic, behavioral, and health care factors related to the occurrence of syphilis in women treated at public maternity hospitals.

    Methods: This is a case-control study (239 cases and 322 controls) with women admitted to seven maternity hospitals in the municipality of Recife, Brazil, from July 2013 to July 2014. Eligible women were recruited after the result of the VDRL (Venereal Disease Research Laboratory) under any titration. Read More

    High Prevalence of Treponema pallidum Infection in Brazilian Prisoners.
    Am J Trop Med Hyg 2017 Oct 18;97(4):1078-1084. Epub 2017 Aug 18.
    Laboratório de Pesquisa em Ciências da Saúde, Universidade Federal da Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, Brazil.
    The number of new syphilis cases in Brazil has risen alarmingly in recent years. However, there is limited data regarding syphilis prevalence in the Brazilian prison population. To facilitate the development of effective interventions, a cross-sectional study was undertaken to determine the prevalence of Treponema pallidum infection, active syphilis, and associated risk factors among Brazilian prisoners. Read More

    New Surge of Syphilis among Patients Living with Human Immunodeficiency Virus in Martinique in 2015.
    Am J Trop Med Hyg 2017 Sep 18;97(3):923-926. Epub 2017 Aug 18.
    INSERM CIC1425, Centre Hospitalier Universitaire de Martinique, Fort de France, France.
    A syphilis outbreak began in Martinique, French Antilles, in 2004, initially among men who had sex with men (MSM) and who were living with human immunodeficiency virus (HIV). The outbreak subsequently affected all groups at risk, leading to a first epidemic peak in 2008. After an initial decrease, the outbreak started growing again in 2014 among patients living with HIV with unprecedented incidence among MSM. Read More

    Knowledge, attitudes and practices towards yaws and yaws-like skin disease in Ghana.
    PLoS Negl Trop Dis 2017 Jul 31;11(7):e0005820. Epub 2017 Jul 31.
    School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana.
    Introduction: Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appropriate community mobilisation. Read More

    Syphilis and HIV prevalence and associated factors to their co-infection, hepatitis B and hepatitis C viruses prevalence among female sex workers in Rwanda.
    BMC Infect Dis 2017 Jul 28;17(1):525. Epub 2017 Jul 28.
    University of Rwanda, College of Medicine and Health Sciences, School of Public Health, Kigali, Rwanda.
    Background: Human Immunodeficiency Virus (HIV), syphilis, Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are sexually transmitted infections (STIs) and share modes of transmission. These infections are generally more prevalent among female sex workers (FSWs).

    Methods: This is a cross-sectional study conducted among female sex workers (FSWs) in Rwanda in 2015. Read More

    Rates of Primary and Secondary Syphilis Among White and Black Non-Hispanic Men Who Have Sex With Men, United States, 2014.
    J Acquir Immune Defic Syndr 2017 Nov;76(3):e65-e73
    *Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA; †Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA; and ‡Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA.
    Background: Men who have sex with men (MSM) in the United States experience an approximately 100-fold greater rate of primary and secondary (P&S) syphilis diagnoses compared with men who have sex with women only. As in the general population, racial/ethnic disparities in P&S syphilis diagnosis rates may exist among MSM, but MSM-specific P&S syphilis rates by race/ethnicity are unavailable. We enhanced a published modeling approach to estimate area-level MSM populations by race/ethnicity and provide the first estimates of P&S syphilis among black and white non-Hispanic MSM. Read More

    A case report of CT-diagnosed renal infarct secondary to syphilitic aortitis.
    BMC Infect Dis 2017 Jul 26;17(1):520. Epub 2017 Jul 26.
    Division of Internal Medicine, Hôpital Neuchâtelois, La Chaux-de-Fonds, Switzerland.
    Background: Even though reported cases of syphilis have been increasing, cases of tertiary syphilis remain extremely rare. The majority of our knowledge with regard to complications of syphilis such as aortitis was acquired before the advent of relatively modern technologies such as CT, MRI and PET. This case report presents a rare case of syphilitic aortitis associated with a renal infarct caused by a peripheral arterial embolism diagnosed by CT. Read More

    The first case of lymphogranuloma venereum in a woman in East-Central Europe and its multiple co-infections.
    Folia Microbiol (Praha) 2017 Jul 24. Epub 2017 Jul 24.
    Department of Dermatovenereology, Second Faculty of Medicine, Charles University and Hospital Bulovka, Budinova 2, 180 81, Prague 8, Czech Republic.
    We are reporting the first case of lymphogranuloma venereum in women in East-Central Europe. A 22-year-old heterosexual woman attended our department of venereology. She complained about a burning sensation in the urethra and vaginal discharge. Read More

    Tertiary syphilis in the lumbar spine: a case report.
    BMC Infect Dis 2017 Jul 24;17(1):513. Epub 2017 Jul 24.
    Department of Spine Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
    Background: The incidence of tertiary syphilis involvement in the spinal column with destructive bone lesions is very rare. It is difficult to establish the correct diagnosis from radiographs and histological examination alone. Limited data are available on surgical treatment to tertiary syphilitic spinal lesions. Read More

    High HIV incidence in men who have sex with men following an early syphilis diagnosis: is there room for pre-exposure prophylaxis as a prevention strategy?
    Sex Transm Infect 2017 Aug 19;93(5):320-322. Epub 2016 Oct 19.
    Chelsea & Westminster Hospital NHS Foundation Trust, London, UK.
    Objectives: HIV pre-exposure prophylaxis (PrEP) is becoming a pivotal strategy for HIV prevention. Understanding the impact of risk factors for HIV transmission to identify those at highest risk would favour the implementation of PrEP, currently limited by costs. In this service evaluation, we estimated the incidence of bacterial STIs in men who have sex with men (MSM) diagnosed with early syphilis attending a London sexual health clinic according to their HIV status. Read More

    The tradition algorithm approach underestimates the prevalence of serodiagnosis of syphilis in HIV-infected individuals.
    PLoS Negl Trop Dis 2017 Jul 20;11(7):e0005758. Epub 2017 Jul 20.
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
    Currently, there are three algorithms for screening of syphilis: traditional algorithm, reverse algorithm and European Centre for Disease Prevention and Control (ECDC) algorithm. To date, there is not a generally recognized diagnostic algorithm. When syphilis meets HIV, the situation is even more complex. Read More

    Transitioning from antenatal surveillance surveys to routine HIV testing: a turning point in the mother-to-child transmission prevention programme for HIV surveillance in Brazil.
    BMC Infect Dis 2017 Jul 5;17(1):469. Epub 2017 Jul 5.
    Department of STI, AIDS and Viral Hepatitis, Secretary for Health Surveillance, Ministry of Health Brazil, SAF Sul, Trecho 02, Bloco F, Torre 1, Edifício Premium, Auditório, Brasília DF, CIE CEP 70070-600, Brazil.
    Background: In Brazil, due to the rapid increase in programmes for the prevention of mother-to-child transmission (PMTCT), routine programme data are widely available. The objective of this study was to assess the utility of programmatic data to replace HIV surveillance based on the antenatal care (ANC) surveillance survey (SS).

    Methods: We analysed ANC SS data from 219 maternity service clinics. Read More

    Factors associated with reinfection of syphilis in reference centers for sexually transmitted infections.
    Rev Saude Publica 2017 Jun 26;51:64. Epub 2017 Jun 26.
    Departamento de Saúde Coletiva. Faculdade de Ciências Médicas da Unicamp. Campinas, SP, Brasil.
    Objective: We aim to analyze trend of syphilis and factors associated with recurrent episodes of syphilis among adults and adolescents attended in a STI/AIDS reference centers in Campinas, state of São Paulo, 2004 to 2012.

    Methods: Medical records, pharmacy data, and notification database were accessed to analyze trends of syphilis and sociodemographic, epidemiological and clinical variables associated with reinfection of syphilis. After univariate analysis, a hierarchical logistic regression model was adjusted to analyze variables associated with more than one episode of syphilis (dependent variable). Read More

    Comparison of efficacy of treatments for early syphilis: A systematic review and network meta-analysis of randomized controlled trials and observational studies.
    PLoS One 2017 28;12(6):e0180001. Epub 2017 Jun 28.
    Reference STD Lab, National Center for STD Control, Chinese CDC, Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China.
    Background: Parenteral penicillin is the first-line regimen for treating syphilis, but unsuitable for some patients due to penicillin allergy and lacking health resources. Unfortunately, the efficacy of penicillin alternatives remains poorly understood. This study aimed to assess the efficacy of ceftriaxone and doxycycline/tetracycline in treating early syphilis relative to that of penicillin, and thereby to determine which antibiotic is a better replacement for penicillin. Read More

    Elimination of mother-to-child transmission of HIV and Syphilis (EMTCT): Process, progress, and program integration.
    PLoS Med 2017 Jun 27;14(6):e1002329. Epub 2017 Jun 27.
    Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
    Melanie Taylor and colleagues discuss progress towards eliminating vertical transmission of HIV and syphilis. Read More

    Syphilis testing practices in the Americas.
    Trop Med Int Health 2017 Sep 19;22(9):1196-1203. Epub 2017 Jul 19.
    HIV, Hepatitis, Tuberculosis and Sexually Transmitted Infections Unit-Communicable Diseases and Health Analysis Department, Pan American Health Organization, Washington, DC, USA.
    Objective: To present the findings of the Pan American Health Organization's 2014 survey on syphilis testing policies and practices in the Americas.

    Methods: Representatives of national/regional reference and large, lower-level laboratories from 35 member states were invited to participate. A semi-structured, electronically administered questionnaire collected data on syphilis tests, algorithms, equipment/commodities, challenges faced and basic quality assurance (QA) strategies employed (i. Read More

    [Consecutive cross-sectional survey of prevalence of HIV infection/STD and related factors in Vietnamese female sex workers at a China-Vietnam border area, 2014-2015].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 May;38(5):638-642
    School of Public Health, Southeast University, Nanjing 210009, China.
    Objective: To investigate the prevalence of HIV infection/STD and related factors in Vietnamese female sex workers (FSWs). Methods: Consecutive cross-sectional surveys were conducted in June 2014, December 2014, May 2015 and November 2015 in Hekou, a county bordering Vietnam in Yunnan province. Convenience sampling were adopted to select 1 058 Vietnamese FSWs aged>16 years. Read More

    Screening for Syphilis and Other Sexually Transmitted Infections in Pregnant Women - Guam, 2014.
    MMWR Morb Mortal Wkly Rep 2017 Jun 23;66(24):644-648. Epub 2017 Jun 23.
    Prenatal screening and treatment for sexually transmitted infections (STIs) can prevent adverse perinatal outcomes. In Guam, the largest of the three U.S. Read More

    Clinical characteristics of acute hepatitis A outbreak in Taiwan, 2015-2016: observations from a tertiary medical center.
    BMC Infect Dis 2017 Jun 20;17(1):441. Epub 2017 Jun 20.
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5 Fuhsing Street, Kueishan, Taoyuan, 333, Taiwan.
    Background: Acute hepatitis A is a fecal-oral transmitted disease related to inadequate sanitary conditions. In addition to its traditional classification, several outbreaks in the men who have sex with men (MSM) population have resulted in acute hepatitis A being recognized as a sexually transmitted disease. However, few studies have clarified the clinical manifestations in these outbreaks involving the MSM population. Read More

    Characteristics of syphilitic uveitis in northern China.
    BMC Ophthalmol 2017 Jun 19;17(1):95. Epub 2017 Jun 19.
    Eye Institute & School of Optometry and Ophthalmology, Tianjin Medical University Eye Hospital, 251 Fukang Road, Nankai District, Tianjin, 300384, China.
    Background: To describe the characteristics of patients with syphilitic uveitis in northern China.

    Methods: A case series of 21 patients (33 eyes) diagnosed with syphilitic uveitis from 2011 to 2016 at a tertiary center in northern China was retrospectively analyzed.

    Results: Twenty-one patients (33 eyes) were diagnosed as syphilitic uveitis. Read More

    The analyzation and clinical evaluation of ECLIA and CMIA in the detection of Treponema pallidum.
    Medicine (Baltimore) 2017 Jun;96(24):e7139
    Department of Clinical Laboratory, Peking University Third Hospital, Beijing, China.
    To evaluate the clinical application value of electrochemiluminescence immunoassay analyzer (ECLIA) and chemiluminescent magnetic microparticle immunoassay (CMIA) in the detection of Treponema pallidum (TP).A total of 1225 patients in Peking University Third Hospital was enrolled from June 2014 to October 2014. ECLIA and CMIA were applied to detect the serum anti-TP. Read More

    Congenital Syphilis of Bone: A Potential Mimicker of Childhood Histiocytoses.
    Am J Surg Pathol 2017 Sep;41(9):1283-1289
    *Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH †Pitts Radiology ‡Pediatric Associates, PA, Columbia, SC.
    Involvement of the skeletal system by congenital syphilis is well documented in the literature, chiefly in the form of radiologic studies, including periostitis, osteitis, and osteochondritis. Because congenital syphilis is generally recognized clinically, tissue biopsy is virtually never performed. Therefore, the histopathologic findings are less well documented and mostly exist in the older literature. Read More

    Syphilis Screening and Diagnosis Among Men Who Have Sex With Men, 2008-2014, 20 U.S. Cities.
    J Acquir Immune Defic Syndr 2017 Jul;75 Suppl 3:S363-S369
    Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
    Background: Annual screening for syphilis is indicated for all sexually active men who have sex with men (MSM).

    Methods: Using National HIV Behavioral Surveillance data from 2008, 2011, and 2014, we assessed trends in self-reported syphilis testing and diagnoses in the past 12 months among MSM. We calculated percentages of syphilis screening and diagnosis by selected characteristics for each year. Read More

    Trends in Hospitalization and Incidence Rate for Syphilitic Uveitis in the United States From 1998 to 2009.
    Am J Ophthalmol 2017 Aug 24;180:133-141. Epub 2017 May 24.
    Byers Eye Institute at Stanford University School of Medicine, Palo Alto, California. Electronic address:
    Purpose: This study evaluates the annual incidence of syphilitic uveitis in the US and trends in hospital admissions over time.

    Design: Retrospective, longitudinal incidence rate analysis of the National Inpatient Sample (NIS) data from 1998 to 2009.

    Methods: The NIS is a de-identified, random sample dataset of inpatient hospitalizations from 46 states. Read More

    Development of real-time PCR and loop-mediated isothermal amplification (LAMP) assays for the differential detection of digital dermatitis associated treponemes.
    PLoS One 2017 25;12(5):e0178349. Epub 2017 May 25.
    Department of Medical Science, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.
    Bovine digital dermatitis (DD) is a severe infectious cause of lameness in cattle worldwide, with important economic and welfare consequences. There are three treponeme phylogroups (T. pedis, T. Read More

    Displayed Wounds, Encrypted Messages: Hyper-Realism and Imagination in Medical Moulages.
    Med Anthropol 2017 Aug-Sep;36(6):533-550. Epub 2017 May 22.
    a Institute of Social Sciences , University of Lisbon , Lisbon , Portugal.
    Moulages are three-dimensional colorful replicas of body parts with particular expressions of ailments. Historically, by operating a transition between illness and disease, moulages were a powerful tool in the consolidation of the medical specialty of dermatovenereology. Yet, moulages are not solely an objectification of biological processes suitable for medical teaching; they also activate non-medical cognitions and emotions about life, death, behavior, and morality that are rooted in the history of the art of wax modeling. Read More

    [The clinical manifestations and imaging characteristics of acute syphilitic posterior placoid chorioretinitis].
    Zhonghua Yan Ke Za Zhi 2017 May;53(5):352-357
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing 100730, China.
    Objective: To investigate the clinical manifestations and imaging characteristics of acute syphilitic posterior placoid chorioretinitis (ASPPC). Methods: Retrospective study of 10 patients diagnosed ASPPC in the Department of Ophthalmology, Beijing Tongren Hospital from 2011 to 2016, including 6 males (10 eyes involved) and 4 females (8 eyes involved) with an age of (43.4±11. Read More

    Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea.
    PLoS Negl Trop Dis 2017 May 10;11(5):e0004958. Epub 2017 May 10.
    Lihir Medical Centre- International SOS, Newcrest Mining, Lihir Island, Papua New Guinea.
    Background: Haemophilus ducreyi and Treponema pallidum subsp. pertenue are major causes of leg ulcers in children in Africa and the Pacific Region. We investigated the presence of DNA (PCR positivity) from these bacteria on asymptomatic people, flies, and household linens in an endemic setting. Read More

    Yaws resurgence in Bankim, Cameroon: The relative effectiveness of different means of detection in rural communities.
    PLoS Negl Trop Dis 2017 May 8;11(5):e0005557. Epub 2017 May 8.
    School of Anthropology, University of Arizona, Tucson, Arizona, United States of America.
    Background: Yaws is an infectious, debilitating and disfiguring disease of poverty that mainly affects children in rural communities in tropical areas. In Cameroon, mass-treatment campaigns carried out in the 1950s reduced yaws to such low levels that it was presumed the disease was eradicated. In 2010, an epidemiological study in Bankim Health District detected 29 cases of yaws. Read More

    Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study.
    BMC Infect Dis 2017 Apr 26;17(1):310. Epub 2017 Apr 26.
    Zhongshan Hospital, Medical College of Xiamen University, Xiamen, 361004, China.
    Background: Known predictors of neurosyphilis were mainly drawn from human immunodeficiency virus (HIV)-infected syphilis patients, which may not be applicable to HIV-negative populations as they have different characteristics, particularly those with neurological symptoms. This study aimed to identify novel predictors of HIV-negative symptomatic neurosyphilis (S-NS).

    Methods: From June 2005 to June 2015, 370 HIV-negative syphilis patients with neurological symptoms were recruited, consisting of 191 S-NS patients (including 123 confirmed neurosyphilis and 68 probable neurosyphilis patients) and 179 syphilis/non-neurosyphilis (N-NS) patients. Read More

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