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    1 OF 562

    Point-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences.
    PLoS Negl Trop Dis 2018 Apr 19;12(4):e0006360. Epub 2018 Apr 19.
    Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, United Kingdom.
    Introduction: The human treponematoses comprise venereal syphilis and the three non-venereal or endemic treponematoses yaws, bejel, and pinta. Serological assays remain the most common diagnostic method for all treponemal infections. Point-of-care tests (POCTs) for syphilis and yaws allow testing without further development of infrastructure in populations where routine laboratory facilities are not available. Read More

    HIV, syphilis and behavioral risk factors among men who have sex with men in a drug-using area of southwestern China: Results of 3 cross-sectional surveys from 2013 to 2015.
    Medicine (Baltimore) 2018 Apr;97(16):e0404
    Department of Health Services Administration, Florida International University, Miami, FL.
    To assess human immunodeficiency virus (HIV), syphilis, and behavioral risk factors among men who have sex with men (MSM) in southwestern China, where HIV started as a drug-driven epidemic, and shifted to mainly heterosexual transmission.These cross-sectional studies were conducted yearly in 2013, 2014, and 2015 in Guangxi, China. A total of 1,996, 1,965, and 1,697 participants were recruited in 2013, 2014, and 2015, respectively. Read More

    Case for diagnosis. Atypical genital lesion.
    An Bras Dermatol 2018 Jan-Feb;93(1):143-144
    Service of Sexually Transmitted Infection - Fundação Alfredo da Matta (FUAM) - Manaus (AM), Brazil.
    We present a case of a penile lesion with a clinical appearance similar to Mondor penile disease (thrombosis of the dorsal vein of the penis) or penile sclerosing lymphangitis. Laboratory evaluation, however, showed a solid lesion, with no vascular component to Doppler ultrasonography and no treponema to immunohistochemistry. Histological and serological tests were compatible with secondary syphilis. Read More

    Corymbiform syphilis associated with three other sexually transmitted infections.
    An Bras Dermatol 2018 Jan-Feb;93(1):129-132
    Dermatology Clinic at Santa Casa de São Paulo - São Paulo (SP), Brazil.
    Secondary syphilis can have different clinical presentations, with corymbiform rash as its rarest manifestation. The disease is characterized by a central papule surrounded by smaller ones. We report the case of a man who has sex with man with corymbiform syphilis. Read More

    Case 9-2018: A 55-Year-Old Man with HIV Infection and a Mass on the Right Side of the Face.
    N Engl J Med 2018 Mar;378(12):1143-1152
    From the Departments of Medicine (K.L.A., R.T.G.), Radiology (H.R.K.), and Pathology (A.L.), Massachusetts General Hospital, the Departments of Medicine (K.L.A., R.T.G.), Radiology (H.R.K.), and Pathology (A.L.), Harvard Medical School, and the Department of Radiology, Massachusetts Eye and Ear (H.R.K.) - all in Boston.

    Estimation of seroprevalence of HIV, hepatitis B and C virus and syphilis among blood donors in the hospital of Aïoun, Mauritania.
    Pan Afr Med J 2017 6;28:118. Epub 2017 Oct 6.
    Department of Infectious Diseases, University Teaching Hospital Donka, Conakry, Guinée.
    Introduction: To estimating the seroprevalence of HIV, hepatitis B, hepatitis C and syphilis among blood donors in the Aïoun hospital.

    Methods: This is a retrospective study from 1 January 2010 to 31 December 2015.

    Results: On the five-year study period, 1,123 donors were collected. Read More

    The clinical and laboratory features of neurosyphilis in HIV-infected patients: A retrospective study in 92 patients.
    Medicine (Baltimore) 2018 Mar;97(9):e0078
    Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University.
    Neurosyphilis (NS) is an important component of central nervous system diseases among HIV-infected patients. However, its characteristics are not very clear. A retrospective analysis of clinical and laboratory findings was performed in 92 NS patients with HIV infection from a tertiary hospital in Shanghai, China. Read More

    Bejel in Cuba: molecular identification of Treponema pallidum subsp. endemicum in patients diagnosed with venereal syphilis.
    Clin Microbiol Infect 2018 Feb 16. Epub 2018 Feb 16.
    Department of Biology, Masaryk University, Brno, 625 00, Czech Republic. Electronic address:
    Objectives: Bejel, caused by Treponema pallidum subsp. endemicum (TEN), was until now considered as a non-venereal disease endemic in areas with hot and dry climates. This study has identified TEN in clinical samples from Cuban patients previously diagnosed with syphilis. Read More

    [Four-year follow-up of a neurosyphilis case presenting psychiatric symptoms].
    Orv Hetil 2018 Feb;159(6):234-238
    Pszichiátriai és Pszichoterápiás Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Balassa u. 6., 1083.
    The authors present a case of neurosyphilis associated with predominant psychiatric symptoms. The elderly man was admitted because of confused behavior, maniform state, lack of critical judgement and grandiose delusions. On admission, right central facial nerve paresis, hand tremor and parkinsonism were also found. Read More

    Syphilis of the lumbar spine: A case report and review of the literature.
    Medicine (Baltimore) 2017 Dec;96(50):e9098
    Department of Orthopedic.
    Rationale: Tertiary syphilis can manifest as gummatous disease, but gumma of the spine has been extremely rarely reported.

    Patient Concerns: A 61-year-old male complained of worsening pain and numbness in both lower legs for four weeks.

    Diagnoses: Syphilis of the Lumbar Spine. Read More

    CXCL13 and TH1/Th2 cytokines in the serum and cerebrospinal fluid of neurosyphilis patients.
    Medicine (Baltimore) 2017 Nov;96(47):e8850
    Department of Neurology.
    Neurosyphilis is a chronic infectious disease with involvement of central nervous system infection by Treponema pallidum. This study was to investigate the contents of B lymphocyte chemokine 1 (BLC-1/chemokine [C-X-C motif] ligand 13), Th1 cytokines (Interleukin [IL]-2, IL-12, and Interferon [IFN]-γ), and Th2 cytokines (IL-6 and IL-10) in serum and cerebrospinal fluid (CSF) of HIV-negative patients with neurosyphilis before and after treatment, aiming to elucidate roles of CXCL13 and Th1/Th2 cytokines in immune response to and pathogenesis of neurosyphilis.Enzyme-linked immunosorbent assay was employed to detect the contents of CXCL13, IL-2, IL-12, IFN-γ, IL-6, and IL-10 in serum and CSF of 47 HIV-negative patients with neurosyphilis, 36 syphilis patients without neurological involvement and 23 controls (noninfectious intracranial disease) before, 3 and 12 months after treatment with high dose penicillin. Read More

    Syphilis Resurgence in Belgrade, Serbia, in the New Millennium: An Outbreak in 2014.
    Cent Eur J Public Health 2017 Dec;25(4):277-281
    Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
    Objective: A worldwide syphilis incidence increase was recorded at the beginning of the new millennium, occurring primarily among men who have sex with men (MSM). The aim of this study was to analyse the epidemiological situation of syphilis in the Belgrade population between 2005 and 2014 and to examine the characteristics of an early syphilis outbreak among MSM in Belgrade in 2014.

    Method: Reporting of syphilis is compulsory in Serbia. Read More

    A Nonhuman Primate Model for Rectally Transmitted Syphilis.
    J Infect Dis 2018 Mar;217(7):1139-1144
    Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
    Among men who have sex with men (MSM), those with a diagnosis of syphilis or other rectal sexually transmitted infections (STIs) are at a higher risk for human immunodeficiency virus acquisition, which is concerning given the large increase in recently reported syphilis cases in the United States. We have developed the first nonhuman primate model for rectally transmitted syphilis by exposing simian/human immunodeficiency virus-infected and naive rhesus macaques to Treponema pallidum in the rectum. All animals showed mucosal lesions, systemic dissemination, and seroconversion (treponemal antibodies). Read More

    Combined evaluation of sexually transmitted infections in HIV-infected pregnant women and infant HIV transmission.
    PLoS One 2018 5;13(1):e0189851. Epub 2018 Jan 5.
    David Geffen UCLA School of Medicine, Los Angeles, CA, United States of America.
    Background: Sexually transmitted infections (STIs) including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Treponema pallidum (TP), and cytomegalovirus (CMV) may lead to adverse pregnancy and infant outcomes. The role of combined maternal STIs in HIV mother-to-child transmission (MTCT) was evaluated in mother-infant pairs from NICHD HPTN 040.

    Methodology: Urine samples from HIV-infected pregnant women during labor were tested by polymerase chain reaction (PCR) for CT, NG, and CMV. Read More

    [Studies on behavior change and related factors among female sex workers in Qingdao city of Shandong province, between 2006 and 2015].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 Dec;38(12):1660-1664
    Department of AIDS/STD Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan 250014, China.
    This study aimed to analyze the behavior change and related factors regarding HIV/STD epidemics among female sex workers (FSWs) in Qingdao city. According to the requirements set by the"National HIV/AIDS sentinel surveillance program", information on demographics, sexual and drug use behaviors, and HIV-related services among female sex workers (FSWs) was collected from ten consecutive annual cross-sectional surveys from 2006 to 2015. Blood samples were drawn for serological tests on both HIV and syphilis antibodies. Read More

    [Results of sentinel surveillance on men who have sex with men in Jilin province between 2010 and 2015].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 Dec;38(12):1655-1659
    Jilin Provincial Center for Disease Control and Prevention, Changchun 130062, China.
    To explore the HIV epidemic and related factors among MSM in Jilin province. During the implementation of sentinel surveillance program from 2010 to 2015, continuous cross-sectional studies were conducted to monitor the awareness of AIDS, sexual behavior, HIV and syphilis positive rates, with the sample size no less than 400 in each surveillance site. From 2010 to 2015, a total of 7 823 MSM were involved in this study. Read More

    [HIV/STD prevalence and related behaviors among male STD clinic attendees in Xi'an and Xianyang cities, Shaanxi province].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 Dec;38(12):1634-1637
    Section of AIDS Control and Prevention, Shaanxi Provincial Center for Disease Control and Prevention, Xi'an 710054, China.
    To compare the prevalence of HIV/STD and related health care seeking behaviors among male STD clinic attendees between Xi'an and Xianyang cities. During June and July 2016, 206 male STD clinic attendees were studied in Xi'an city, with another 221 male STD clinic attendees in Xianyang city. Cross-sectional questionnaire survey was used to collect attendees'behavioral information. Read More

    [Gene expression profiling of peripheral blood mononuclear cells in patients with secondary syphilis].
    Zhonghua Nan Ke Xue 2016 Dec;22(12):1104-1109
    Institute of Dermatology, Peking Union Medical College, Chinese Academy of Medical Sciences, Nanjing, Jiangsu 210042, China.
    Objective: To analyze the gene expression profiling characteristics of peripheral blood mononuclear cells (PBMCs) from patients with secondary syphilis, and gain an insight into the host molecular immune mechanisms involved in Treponema pallidum infection.

    Methods: Using genome-based high-throughput Illumina sequencing technology, we comprehensively determined the transcriptional difference in PBMCs from 4 secondary syphilis patients and 4 healthy controls, followed by real time PCR to validate the results of Illumina sequencing.

    Results: Totally, 78 differentially expressed genes were found in the PBMCs of the secondary syphilis patients, among which 16 were associated with the immune system. Read More

    Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea.
    PLoS Negl Trop Dis 2017 12 27;11(12):e0006113. Epub 2017 Dec 27.
    Department of Medicine, University of Washington, Seattle, Washington, United States of America.
    Background: Yaws is a neglected tropical disease, caused by Treponema pallidum subsp. pertenue. The disease causes chronic lesions, primarily in young children living in remote villages in tropical climates. Read More

    Clinical Profile and Outcomes of Optic Neuritis in an HIV Prevalent Urban Community in South Africa.
    Middle East Afr J Ophthalmol 2017 Jul-Sep;24(3):131-135
    Division of Ophthalmology, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa.
    Purpose: To determine the clinical profile, causes and response to corticosteroid therapy in patients admitted and treated for optic neuritis at a tertiary hospital in Cape Town, South Africa.

    Methods: A retrospective case review of 117 patients with optic neuritis between January 2002 and December 2012. Demographic information, clinical presentation, course of illness, investigations performed and visual outcomes at discharge and at three month follow up were collected for analysis. Read More

    Between Colonial, National, and International Medicine: The Case of Bejel.
    Bull Hist Med 2017 ;91(4):744-771
    In the 1920s and 1930s, doctors stationed in the Middle East and North Africa debated whether bejel, a form of endemic syphilis, was an Arab version of syphilis, or a separate disease altogether. Using their clinical experience in the region, they tried to weave this unfamiliar phenomenon into a civilizational narrative, which placed European civilization at the top of a hierarchy. The assumption was that there was something inherent to Islamic societies and their hygienic habits that accounted for this difference. Read More

    The magnitude of syphilis: from prevalence to vertical transmission.
    Rev Inst Med Trop Sao Paulo 2017 Dec 21;59:e78. Epub 2017 Dec 21.
    Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Rio de Janeiro, Rio de Janeiro, Brazil.
    Introduction: In 2013, the World Health Organization (WHO) reported that 1.9 million pregnant women were infected with syphilis worldwide, of which 66.5% had adverse fetal effects in cases of untreated syphilis. Read More

    The Etiology of Genital Ulcer Disease and Coinfections With Chlamydia trachomatis and Neisseria gonorrhoeae in Zimbabwe: Results From the Zimbabwe STI Etiology Study.
    Sex Transm Dis 2018 Jan;45(1):61-68
    From the *Zimbabwe Ministry of Health and Child Care; †Department of Community Medicine, University of Zimbabwe, College of Health Sciences, Harare, Zimbabwe; ‡US Centers for Disease Control and Prevention, Zimbabwe and Division of Global HIV/AIDS, CDC, Atlanta, GA; §Fogarty International Center, National Institutes of Health, Bethesda, MD; ¶Zimbabwe Community Health Intervention Research (ZiCHIRe) Project, Harare, Zimbabwe; ∥Western Sydney Sexual Health Centre, Parramatta; **Marie Bashir Institute for Infectious Diseases and Biosecurity & Sydney Medical School-Westmead, University of Sydney, Sydney, New South Wales, Australia; ††School of Medicine, University of Washington, Seattle, WA; ‡‡Colorado School of Public Health, University of Colorado Denver, Denver, CO; §§Rietmeijer Consulting LLC, Denver, CO.
    Background: In many countries, sexually transmitted infections (STIs) are treated syndromically. Thus, patients diagnosed as having genital ulcer disease (GUD) in Zimbabwe receive a combination of antimicrobials to treat syphilis, chancroid, lymphogranuloma venereum (LGV), and genital herpes. Periodic studies are necessary to assess the current etiology of GUD and assure the appropriateness of current treatment guidelines. Read More

    Factors associated with four atypical cases of congenital syphilis in England, 2016 to 2017: an ecological analysis.
    Euro Surveill 2017 Dec;22(49)
    HIV & STI Department, Public Health England, Colindale, London, United Kingdom.
    Four isolated cases of congenital syphilis born to mothers who screened syphilis negative in the first trimester were identified between March 2016 and January 2017 compared with three cases between 2010 and 2015. The mothers were United Kingdom-born and had no syphilis risk factors. Cases occurred in areas with recent increases in sexually-transmitted syphilis among women and men who have sex with men, some behaviourally bisexual, which may have facilitated bridging between sexual networks. Read More

    Advancing prevention of sexually transmitted infections through point-of-care testing: target product profiles and landscape analysis.
    Sex Transm Infect 2017 12;93(S4):S69-S80
    Department of Reproductive Health and Research, World Health Organization (WHO), Geneva, Switzerland.
    Objectives: Advancing the field of point-of-care testing (POCT) for STIs can rapidly and substantially improve STI control and prevention by providing targeted, essential STI services (case detection and screening). POCT enables definitive diagnosis and appropriate treatment in a single visit and home and community-based testing.

    Methods: Since 2014, the WHO Department of Reproductive Health and Research, in collaboration with technical partners, has completed four landscape analyses of promising diagnostics for use at or near the point of patient care to detect syphilis, , , and the human papillomavirus. Read More

    Assessing stakeholder perceptions of the acceptability and feasibility of national scale-up for a dual HIV/syphilis rapid diagnostic test in Malawi.
    Sex Transm Infect 2017 12;93(S4):S59-S64
    Division of Sexually Transmitted Disease Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
    Objectives: The WHO recommends pregnant women receive both HIV and syphilis testing at their first antenatal care visit, as untreated maternal infections can lead to severe, adverse pregnancy outcomes. One strategy for increasing testing for both HIV and syphilis is the use of point-of-care (rapid) diagnostic tests that are simple, proven effective and inexpensive. In Malawi, pregnant women routinely receive HIV testing, but only 10% are tested for syphilis at their first antenatal care visit. Read More

    Field evaluation of two point-of-care tests for syphilis among men who have sex with men, Verona, Italy.
    Sex Transm Infect 2017 12;93(S4):S51-S58
    Infectious Diseases Section, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
    Objectives: The incidence of HIV and syphilis among men who have sex with men (MSM) in Europe has recently increased. Rapid point-of-care tests (POCTs) for syphilis can improve access to screening. The purpose of this study was to evaluate the performance of two syphilis POCTs compared with laboratory tests among MSM. Read More

    Evaluation of seven rapid tests for syphilis available in Brazil using defibrinated plasma panels.
    Sex Transm Infect 2017 12;93(S4):S46-S50
    Department of Surveillance, Prevention and Control of Sexually Transmitted Infections, HIV/AIDS and Viral Hepatitis, Secretariat of Health Surveillance, Ministry of Health, Setor Administrativo Federal Sul, Brasília, Distrito Federal, Brazil.
    Objectives: In 2012, the WHO estimated that 6 million new cases of syphilis per year would occur worldwide, including 937 000 in Brazil. Early diagnosis and treatment of syphilis are essential to reduce morbidity and prevent transmission. The availability of rapid tests (RTs) for this diagnosis means that testing can be performed more quickly, as a point-of-care test, even in non-laboratory environments and requires only simple technical training to antibodies detection. Read More

    Subacute loss of vision in one eye · rash on hands and feet · plaques with scaling on genitals · Dx?
    J Fam Pract 2017 Dec;66(12):E9-E11
    Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA.
    A 67-year-old man presented to the hospital with subacute loss of vision in his left eye. The visual changes began 2 weeks earlier, with a central area of visual loss that had since progressed to near complete vision loss in the left eye. Physical examination revealed patchy alopecia, a scaling and hyperkeratotic rash of his hands and feet, and blanching, erythematous plaques with associated scaling on the scrotum and glans penis. Read More

    Pathogen reduction and blood transfusion safety in Africa: strengths, limitations and challenges of implementation in low-resource settings.
    Vox Sang 2018 Jan 30;113(1):3-12. Epub 2017 Nov 30.
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Transfusion-transmitted infection risk remains an enduring challenge to blood safety in Africa. A high background incidence and prevalence of the major transfusion-transmitted infections (TTIs), dependence on high-risk donors to meet demand, suboptimal testing and quality assurance collectively contribute to the increased risk. With few exceptions, donor testing is confined to serological evaluation of human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) and syphilis. Read More

    VITREOUS TREPONEMAL ANTIBODY AS A SUPPLEMENTARY TEST TO SEROLOGY FOR THE CONFIRMATION OF SYPHILITIC CHORIORETINITIS.
    Retin Cases Brief Rep 2017 Nov 22. Epub 2017 Nov 22.
    Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts.
    Purpose: To report the novel application of nontreponemal and treponemal antibody to confirm diagnosis of ocular syphilis from vitreous samples.

    Methods: Two distinct case reports emphasizing the importance of confirmatory vitreous treponemal antibody. Multimodal imaging of patients was also applied. Read More

    Prevalence of syphilis and HIV infection during pregnancy in incarcerated women and the incidence of congenital syphilis in births in prison in Brazil.
    Cad Saude Publica 2017 Nov 21;33(11):e00183616. Epub 2017 Nov 21.
    Sorbonne Universités, UPMC Univ Paris 06, INSERM, IPLESP UMRS 1132, F75012 Paris, France.
    This study aimed to estimate the prevalence of syphilis and HIV infection during pregnancy, the mother to child transmission of syphilis and the incidence of congenital syphilis in incarcerated women in Brazil; to compare these rates to those observed in pregnant women outside of jail; and to verify the maternal factors associated with syphilis infection during pregnancy in free and incarcerated women. We used data from two nationwide studies conducted during the period 2011-2014. The Birth in Brazil study included 23,894 free women cared for in 266 hospitals. Read More

    Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study.
    BMJ 2017 Nov 21;359:j5018. Epub 2017 Nov 21.
    National Institute of Population Medical Genetics (INAGEMP), Porto Alegre, Brazil.
     To describe the prevalence and clinical spectrum of microcephaly in South America for the period 2005-14, before the start of the Zika epidemic in 2015, as a baseline for future surveillance as the Zika epidemic spreads and as other infectious causes may emerge in future. Prevalence and case-control study. ECLAMC (Latin American Collaborative Study of Congenital Malformations) database derived from 107 hospitals in 10 South American countries, 2005 to 2014. Read More

    Syphilis and HIV infections among pregnant women attending antenatal clinics in Republic of Congo.
    Pan Afr Med J 2017 7;28. Epub 2017 Sep 7.
    Laboratoire National de Santé Publique, 120 avenue du Général Charles de Gaule, BP: 120 Brazzaville, Congo.
    Introduction: HIV and syphilis during pregnancy remain a public health concern especially in developing countries. Pregnant women attending antenatal clinics sites for the first time between September and December 2011 and who accepted to participate in the study were enrolled. The objective was to estimate the syphilis and HIV infection rate in this population. Read More

    Comparison of seropositivity of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis among Hospital Cornea Retrieval Programme-Donors versus voluntary cornea donors at a large eye bank in Eastern India.
    Indian J Ophthalmol 2017 Nov;65(11):1138-1142
    Department of Cornea and Eye Bank Services, Disha Eye Hospitals, Kolkata, West Bengal, India.
    Purpose: To compare the serology profile of donors from Hospital Cornea Retrieval Programme-donors (HCRP-D) and voluntary cornea donors (VC-D) from a large eye bank in Eastern India.

    Methods: This is a retrospective analysis of donor details from January 2011 to December 2016. Donor demographics, cause of death, and serology reports were compiled. Read More

    Secondary syphilis presenting as leucoderma syphiliticum: case report and review.
    Rev Inst Med Trop Sao Paulo 2017 Nov 6;59:e74. Epub 2017 Nov 6.
    Universidade Federal do Estado do Rio de Janeiro, Hospital Universitário Gaffrée e Guinle, Centro de Ciências Biológicas e da Saúde, Rio de Janeiro, Rio de Janeiro, Brazil.
    Leucoderma syphiliticum (LS), originally described as syphilide pigmentaire, encompasses a spectrum of dyschromic lesions that emerge during the course of secondary syphilis. Very few case reports are available in modern biomedical databases. We present the case of a 57-year-old HIV-infected male patient who presented with several round to oval, non-scaling, slightly raised and well-demarcated hypochromic lesions scattered over the trunk, abdomen, dorsum, and arms. Read More

    Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study.
    Lancet Glob Health 2017 12 26;5(12):e1268-e1274. Epub 2017 Oct 26.
    Barcelona Institute for Global Health, Hospital Clinic-University of Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique; Paediatric Infectious Diseases Unit, Paediatric Department, Hospital Sant Joan de Déu Barcelona, Barcelona, Spain.
    Background: Treatment of latent yaws is a crucial component of the WHO yaws eradication strategy to prevent relapse and the resulting transmission to uninfected children. We assessed the effectiveness of single-dose azithromycin to treat patients with latent yaws.

    Methods: This population-based cohort study included children (age <20 years) living on Lihir Island, Papua New Guinea, with high-titre (rapid plasma reagin titre ≥1:8) latent or active yaws, between April, 2013, and May, 2015. Read More

    Chemical composition and insecticidal activity of the essential oil from Helichrysum faradifani endemic to Madagascar.
    Nat Prod Res 2017 Nov 3:1-9. Epub 2017 Nov 3.
    f School of Pharmacy , University of Camerino , Camerino , Italy.
    Helichrysum faradifani (Asteraceae) is a perennial shrub growing in rocky and sandy places of Madagascar. The plant is used in the Malagasy traditional medicine as a wound-healing agent, disinfectant and for the treatment of syphilis, diarrhea, cough and headache. In the present work, we analysed the chemical composition of the essential oil distilled from the aerial parts of H. Read More

    Orofacial Involuntary Movements in Neurosyphilis: Beyond the Candy Sign.
    Tremor Other Hyperkinet Mov (N Y) 2017 5;7:507. Epub 2017 Oct 5.
    Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore-560029, Karnataka, India.
    Background: Involvement of the central nervous system in patients with syphilis (neurosyphilis) may result in several neuropsychiatric symptoms. Rarely, patients with neurosyphillis may develop movement disorders with different phenomenology. Subtle orofacial dyskinesias have been reported in patients with neurosyphilis, known as the candy sign. Read More

    The cost and cost-effectiveness of rapid testing strategies for yaws diagnosis and surveillance.
    PLoS Negl Trop Dis 2017 Oct 26;11(10):e0005985. Epub 2017 Oct 26.
    Unit of General Epidemiology and Disease Control, Institute of Tropical Medicine, Antwerp, Belgium.
    Background: Yaws is a non-venereal treponemal infection caused by Treponema pallidum subspecies pertenue. The disease is targeted by WHO for eradication by 2020. Rapid diagnostic tests (RDTs) are envisaged for confirmation of clinical cases during treatment campaigns and for certification of the interruption of transmission. Read More

    Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: A retrospective case study.
    Medicine (Baltimore) 2017 Oct;96(43):e8376
    aDepartment of Ophthalmology, The Affiliated Guangren Hospital of Xi'an Jiaotong University College of Medicine bDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
    Syphilitic chorioretinitis should be included in differential diagnosis of any form of ocular inflammation. A significantly higher proportion of human immunodeficiency virus (HIV)-positive patients with ocular syphilis as compared to HIV-negative cases have been reported in published studies. However, the clinical signs and symptoms are more insidious in HIV-negative patients who are easily misdiagnosed. Read More

    [Co-infections of HIV, syphilis and HSV-2 among men who have sex with men at the voluntary HIV counseling and testing clinics in Shanghai].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 Oct;38(10):1363-1366
    Putuo District Center for Disease Control and Prevention, Shanghai 200333, China.
    To understand the prevalence rates of HIV-syphilis and HIV-herpes simplex virus 2 (HSV-2) co-infections and related factors among men having sex with men (MSM) who had visited the voluntary HIV counseling and testing (VCT) clinics in Shanghai, China. 756 eligible MSM who attended the VCT clinics of Shanghai Municipality and Putuo district during March to August, 2015 were recruited to participate in a cross-sectional survey with questionnaire interview and blood testing for HIV, syphilis and HSV-2. A total of 732 participants completed a valid questionnaire survey. Read More

    Screening for HIV, hepatitis B and syphilis on dried blood spots: A promising method to better reach hidden high-risk populations with self-collected sampling.
    PLoS One 2017 20;12(10):e0186722. Epub 2017 Oct 20.
    Department of Medical Microbiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
    Introduction: Many people at high risk for sexually transmitted infections (STIs), e.g., men who have sex with men (MSM), are not optimally reached by current sexual health care systems with testing. Read More

    Transfusion Transmissible Infections Among Walk-In Blood Donors at Kisumu Regional Blood Transfusion Centre, Kisumu County, Kenya, 2015.
    Lab Med 2017 Nov;48(4):362-366
    PIRET Partners Consulting, Washington, DC.
    Background: Transfusion transmissible infections (TTIs) are threats to blood safety. This study investigated TTIs among volunteer blood donors at the Kisumu Regional Blood Transfusion Centre (KRBTC) in Kenya.

    Methods: We performed a retrospective record review of blood donor registers at KRBTC, 2015. Read More

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