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    Knowledge, attitudes and practices towards yaws and yaws-like skin disease in Ghana.
    PLoS Negl Trop Dis 2017 Jul 31;11(7):e0005820. Epub 2017 Jul 31.
    School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana.
    Introduction: Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appropriate community mobilisation. Read More

    The first case of lymphogranuloma venereum in a woman in East-Central Europe and its multiple co-infections.
    Folia Microbiol (Praha) 2017 Jul 24. Epub 2017 Jul 24.
    Department of Dermatovenereology, Second Faculty of Medicine, Charles University and Hospital Bulovka, Budinova 2, 180 81, Prague 8, Czech Republic.
    We are reporting the first case of lymphogranuloma venereum in women in East-Central Europe. A 22-year-old heterosexual woman attended our department of venereology. She complained about a burning sensation in the urethra and vaginal discharge. Read More

    High HIV incidence in men who have sex with men following an early syphilis diagnosis: is there room for pre-exposure prophylaxis as a prevention strategy?
    Sex Transm Infect 2017 Aug 19;93(5):320-322. Epub 2016 Oct 19.
    Chelsea & Westminster Hospital NHS Foundation Trust, London, UK.
    Objectives: HIV pre-exposure prophylaxis (PrEP) is becoming a pivotal strategy for HIV prevention. Understanding the impact of risk factors for HIV transmission to identify those at highest risk would favour the implementation of PrEP, currently limited by costs. In this service evaluation, we estimated the incidence of bacterial STIs in men who have sex with men (MSM) diagnosed with early syphilis attending a London sexual health clinic according to their HIV status. Read More

    The tradition algorithm approach underestimates the prevalence of serodiagnosis of syphilis in HIV-infected individuals.
    PLoS Negl Trop Dis 2017 Jul 20;11(7):e0005758. Epub 2017 Jul 20.
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
    Currently, there are three algorithms for screening of syphilis: traditional algorithm, reverse algorithm and European Centre for Disease Prevention and Control (ECDC) algorithm. To date, there is not a generally recognized diagnostic algorithm. When syphilis meets HIV, the situation is even more complex. Read More

    Factors associated with reinfection of syphilis in reference centers for sexually transmitted infections.
    Rev Saude Publica 2017 Jun 26;51:64. Epub 2017 Jun 26.
    Departamento de Saúde Coletiva. Faculdade de Ciências Médicas da Unicamp. Campinas, SP, Brasil.
    Objective: We aim to analyze trend of syphilis and factors associated with recurrent episodes of syphilis among adults and adolescents attended in a STI/AIDS reference centers in Campinas, state of São Paulo, 2004 to 2012.

    Methods: Medical records, pharmacy data, and notification database were accessed to analyze trends of syphilis and sociodemographic, epidemiological and clinical variables associated with reinfection of syphilis. After univariate analysis, a hierarchical logistic regression model was adjusted to analyze variables associated with more than one episode of syphilis (dependent variable). Read More

    Elimination of mother-to-child transmission of HIV and Syphilis (EMTCT): Process, progress, and program integration.
    PLoS Med 2017 Jun 27;14(6):e1002329. Epub 2017 Jun 27.
    Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
    Melanie Taylor and colleagues discuss progress towards eliminating vertical transmission of HIV and syphilis. Read More

    Syphilis testing practices in the Americas.
    Trop Med Int Health 2017 Jun 27. Epub 2017 Jun 27.
    HIV, Hepatitis, Tuberculosis and Sexually Transmitted Infections Unit-Communicable Diseases and Health Analysis Department, Pan American Health Organization, Washington, DC, USA.
    Objective: To present the findings of the Pan American Health Organization's 2014 survey on syphilis testing policies and practices in the Americas.

    Methods: Representatives of national/regional reference and large, lower-level laboratories from 35 member states were invited to participate. A semi-structured, electronically administered questionnaire collected data on syphilis tests, algorithms, equipment/commodities, challenges faced and basic quality assurance (QA) strategies employed (i. Read More

    Screening for Syphilis and Other Sexually Transmitted Infections in Pregnant Women - Guam, 2014.
    MMWR Morb Mortal Wkly Rep 2017 Jun 23;66(24):644-648. Epub 2017 Jun 23.
    Prenatal screening and treatment for sexually transmitted infections (STIs) can prevent adverse perinatal outcomes. In Guam, the largest of the three U.S. Read More

    The analyzation and clinical evaluation of ECLIA and CMIA in the detection of Treponema pallidum.
    Medicine (Baltimore) 2017 Jun;96(24):e7139
    Department of Clinical Laboratory, Peking University Third Hospital, Beijing, China.
    To evaluate the clinical application value of electrochemiluminescence immunoassay analyzer (ECLIA) and chemiluminescent magnetic microparticle immunoassay (CMIA) in the detection of Treponema pallidum (TP).A total of 1225 patients in Peking University Third Hospital was enrolled from June 2014 to October 2014. ECLIA and CMIA were applied to detect the serum anti-TP. Read More

    Trends in Hospitalization and Incidence Rate for Syphilitic Uveitis in the United States From 1998 to 2009.
    Am J Ophthalmol 2017 Aug 24;180:133-141. Epub 2017 May 24.
    Byers Eye Institute at Stanford University School of Medicine, Palo Alto, California. Electronic address:
    Purpose: This study evaluates the annual incidence of syphilitic uveitis in the US and trends in hospital admissions over time.

    Design: Retrospective, longitudinal incidence rate analysis of the National Inpatient Sample (NIS) data from 1998 to 2009.

    Methods: The NIS is a de-identified, random sample dataset of inpatient hospitalizations from 46 states. Read More

    Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea.
    PLoS Negl Trop Dis 2017 May 10;11(5):e0004958. Epub 2017 May 10.
    Lihir Medical Centre- International SOS, Newcrest Mining, Lihir Island, Papua New Guinea.
    Background: Haemophilus ducreyi and Treponema pallidum subsp. pertenue are major causes of leg ulcers in children in Africa and the Pacific Region. We investigated the presence of DNA (PCR positivity) from these bacteria on asymptomatic people, flies, and household linens in an endemic setting. Read More

    Yaws resurgence in Bankim, Cameroon: The relative effectiveness of different means of detection in rural communities.
    PLoS Negl Trop Dis 2017 May 8;11(5):e0005557. Epub 2017 May 8.
    School of Anthropology, University of Arizona, Tucson, Arizona, United States of America.
    Background: Yaws is an infectious, debilitating and disfiguring disease of poverty that mainly affects children in rural communities in tropical areas. In Cameroon, mass-treatment campaigns carried out in the 1950s reduced yaws to such low levels that it was presumed the disease was eradicated. In 2010, an epidemiological study in Bankim Health District detected 29 cases of yaws. Read More

    Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study.
    BMC Infect Dis 2017 Apr 26;17(1):310. Epub 2017 Apr 26.
    Zhongshan Hospital, Medical College of Xiamen University, Xiamen, 361004, China.
    Background: Known predictors of neurosyphilis were mainly drawn from human immunodeficiency virus (HIV)-infected syphilis patients, which may not be applicable to HIV-negative populations as they have different characteristics, particularly those with neurological symptoms. This study aimed to identify novel predictors of HIV-negative symptomatic neurosyphilis (S-NS).

    Methods: From June 2005 to June 2015, 370 HIV-negative syphilis patients with neurological symptoms were recruited, consisting of 191 S-NS patients (including 123 confirmed neurosyphilis and 68 probable neurosyphilis patients) and 179 syphilis/non-neurosyphilis (N-NS) patients. Read More

    Amoxicillin and Ceftriaxone as Treatment Alternatives to Penicillin for Maternal Syphilis.
    Emerg Infect Dis 2017 May;23(5):827-829
    There is no proven alternative to penicillin for treatment of maternal syphilis. We report 2 case-patients with maternal syphilis who were successfully treated without penicillin. We used amoxicillin and probenecid for the first case-patient and amoxicillin, probenecid, and ceftriaxone for the second case-patient. Read More

    Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999-2012.
    Emerg Infect Dis 2017 May;23(5):816-819
    Survey results showed treponemal infection among pet macaques in Southeast Asia, a region with a high prevalence of human yaws. This finding, along with studies showing treponemal infection in nonhuman primates in Africa, should encourage a One Health approach to yaws eradication and surveillance activities, possibly including monitoring of nonhuman primates in yaws-endemic regions. Read More

    Epidemiological features of and changes in incidence of infectious diseases in China in the first decade after the SARS outbreak: an observational trend study.
    Lancet Infect Dis 2017 Jul 12;17(7):716-725. Epub 2017 Apr 12.
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. Electronic address:
    Background: The model of infectious disease prevention and control changed significantly in China after the outbreak in 2003 of severe acute respiratory syndrome (SARS), but trends and epidemiological features of infectious diseases are rarely studied. In this study, we aimed to assess specific incidence and mortality trends of 45 notifiable infectious diseases from 2004 to 2013 in China and to investigate the overall effectiveness of current prevention and control strategies.

    Methods: Incidence and mortality data for 45 notifiable infectious diseases were extracted from a WChinese public health science data centre from 2004 to 2013, which covers 31 provinces in mainland China. Read More

    Molecular subtyping of Treponema pallidum and associated factors of serofast status in early syphilis patients: Identified novel genotype and cytokine marker.
    PLoS One 2017 14;12(4):e0175477. Epub 2017 Apr 14.
    Department of Dermatology, Wuxi Second Hospital, Nanjing Medical University, Wuxi, China.
    Serofast, a persistent nontreponemal serological response observed in early syphilis patients after conventional treatment, remains a concern of clinicians and syphilis patients. No consensus has been established, however, that defines an effective treatment strategy and clarifies the pathogenesis. In this study, 517 patients with early syphilis were enrolled and treated. Read More

    Syphilis Masquerading As Mass Lesions: The Utility of Modern-Day Imaging and Molecular Sequencing in Clinical Diagnosis.
    Sex Transm Dis 2017 May;44(5):303-305
    From the *Department of Infectious Diseases, Institute of Infectious Diseases and Epidemiology, and †Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore.
    Syphilis has been known to present in a myriad of symptoms throughout the ages, and until this day, the diagnosis remains elusive to the modern physician. We present 2 unusual cases of syphilis that posed diagnostic challenges even in the current era of new and advancing diagnostic tests. Read More

    Mobile Phone and Internet Use Mostly for Sex-Seeking and Associations With Sexually Transmitted Infections and Sample Characteristics Among Black/African American and Hispanic/Latino Men Who Have Sex With Men in 3 US Cities.
    Sex Transm Dis 2017 May;44(5):284-289
    From the *Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA; †Brown University, Providence, RI; and ‡Health Resources in Action, Boston, MA.
    Background: Men who have sex with men (MSM) have a relatively high prevalence of sexually transmitted infections (STIs). This study examines the association of self-reported STIs and use of mobile phones and/or computer-based Internet to meet sexual partners among black and Hispanic/Latino MSM in the United States.

    Methods: Black and Hispanic/Latino MSM (N = 853) were recruited from 3 US cities (Chicago, IL; Kansas City, MO; and Fort Lauderdale, FL) via online and community outreach. Read More

    Dorsal longitudinal foreskin cut is associated with reduced risk of HIV, syphilis and genital herpes in men: a cross-sectional study in Papua New Guinea.
    J Int AIDS Soc 2017 Apr;20(1):1-11
    Public Health Intervention Research Group, Kirby Institute, UNSW Australia, Sydney, Australia.
    Introduction: Various forms of penile foreskin cutting are practised in Papua New Guinea. In the context of an ecological association observed between HIV infection and the dorsal longitudinal foreskin cut, we undertook an investigation of this relationship at the individual level.

    Methods: We conducted a cross-sectional study among men attending voluntary confidential HIV counselling and testing clinics. Read More

    Community engagement in sexual health and uptake of HIV testing and syphilis testing among MSM in China: a cross-sectional online survey.
    • Authors:
    J Int AIDS Soc 2017 Feb;20(1):1-10
    Introduction: HIV and syphilis testing rates remain low among men who have sex with men (MSM) in low- and middle-income countries (LMICs). Community engagement has been increasingly used to promote HIV testing among key populations in high-income countries, often in settings with stronger civil society. This study aimed to assess socio-demographic, behavioural, and community engagement factors associated with HIV and syphilis testing among MSM in China. Read More

    Disparities in HIV and syphilis prevalence and risk factors between older male clients with and without steady sex partners in southwestern rural China.
    BMC Infect Dis 2017 Apr 12;17(1):269. Epub 2017 Apr 12.
    Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, No.18 Jinzhou Road, Nanning, Guangxi, China.
    Background: Heterosexual intercourse accounted for 93% of reported HIV cases in Guangxi, and Guangxi had 10% of China's total number of reported HIV cases. Older men are particularly vulnerable to STIs, for example, 46% of Guangxi's HIV cases were men over 50 years of age. As this is an under-studied population in China, effective prevention and control policies have yet to be developed. Read More

    Economic Disparities and Syphilis Incidence in Massachusetts, 2001-2013.
    Public Health Rep 2017 May/Jun;132(3):309-315. Epub 2017 Apr 12.
    1 Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Boston, MA, USA.
    Objectives: We used area-level indicators of poverty to describe economic disparities in the incidence rate of infectious syphilis in Massachusetts to (1) determine whether methods developed in earlier AIDS analyses in Massachusetts could be applied to syphilis and (2) characterize syphilis trends during a time of increased rates of syphilis incidence.

    Methods: Using census tract data and population counts from the US Census Bureau and Massachusetts data on syphilis, we analyzed the incidence rate of syphilis infection from 2001 to 2013 by the poverty level of the census tract in which people with syphilis resided, stratified by age, sex, and race/ethnicity.

    Results: The syphilis incidence rate increased in all census tract groups in Massachusetts from 2001 to 2013, and disparities in incidence rates by area poverty level persisted over time. Read More

    The PICASSO Cohort: baseline characteristics of a cohort of men who have sex with men and male-to-female transgender women at high risk for syphilis infection in Lima, Peru.
    BMC Infect Dis 2017 Apr 11;17(1):255. Epub 2017 Apr 11.
    David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.
    Background: Men who have sex with men (MSM) and male-to-female transgender women (transwomen) are disproportionately at risk of syphilis infection in Peru.

    Methods: From 2013 to 2014, MSM and transwomen seeking human immunodeficiency virus (HIV) or sexually transmitted infection (STI) testing and/or treatment were recruited into a 2-year observational cohort study to determine predictors of recently acquired syphilis infection (defined as a rapid plasma reagin [RPR] titer ≥1:16 and a reactive treponemal antibody test) in Lima, Peru. At baseline, interviewers collected sociodemographic, behavioral, and medical characteristics from participants. Read More

    State-Specific Rates of Primary and Secondary Syphilis Among Men Who Have Sex with Men - United States, 2015.
    MMWR Morb Mortal Wkly Rep 2017 Apr 7;66(13):349-354. Epub 2017 Apr 7.
    In 2015, the rate of reported primary and secondary syphilis in the United States was 7.5 cases per 100,000 population, nearly four times the previous lowest documented rate of 2.1 in 2000 (1). Read More

    Syphilization and Its Discontents: Experimental Inoculation against Syphilis at the London Lock Hospital.
    Bull Hist Med 2017 ;91(1):1-32
    In 1867 James Lane and George Gascoyen, surgeons to the London Lock Hospital, compiled a report on their experiments with a new and controversial treatment. The procedure, known as "syphilization," saw patients be inoculated with infective matter taken from a primary syphilitic ulcer or the artificial sores produced in another patient. Each patient received between 102 and 468 inoculations to determine whether syphilization could cure syphilis and produce immunity against reinfection. Read More

    Prevalence and factors associated with syphilis in a Reference Center.
    Rev Soc Bras Med Trop 2017 Jan-Feb;50(1):27-34
    Departamento de Enfermagem, Universidade Estadual de Londrina, Londrina, PR, Brasil.
    Introduction:: The implementation of the rapid test (RT) for syphilis increases access of vulnerable populations to early diagnosis and treatment, impacting the outcomes of infection. We aimed to assess the prevalence of and factors associated with syphilis in a Center for Testing and Counseling (CTC).

    Methods:: We conducted a cross-sectional study at a Reference Center for sexually transmitted disease (STD) and acquired immune deficiency syndrome in Londrina, Northern Paraná State, Southern Brazil. Read More

    Early malignant syphilis.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):148-150
    Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
    Early malignant syphilis is a rare and severe variant of secondary syphilis. It is clinically characterized by lesions, which can suppurate and be accompanied by systemic symptoms such as high fever, asthenia, myalgia, and torpor state. We report a diabetic patient with characteristic features of the disease showing favorable evolution of the lesions after appropriate treatment. Read More

    Ultra-Wide-Field Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography Findings in Syphilitic Outer Retinitis.
    Ophthalmic Surg Lasers Imaging Retina 2017 Mar;48(3):208-215
    Background And Objective: To determine the ultra-wide-field fundus autofluorescence (UWFFAF) and optical coherence tomography (OCT) features of syphilitic outer retinopathy (SOR).

    Patients And Methods: Retrospective chart review.

    Results: Three patients with SOR were investigated. Read More

    Neutropenia induced by high-dose intravenous benzylpenicillin in treating neurosyphilis: Does it really matter?
    PLoS Negl Trop Dis 2017 Mar 13;11(3):e0005456. Epub 2017 Mar 13.
    Sexually Transmitted Disease Institute, Shanghai Skin Disease Hospital, Shanghai, People's Republic of China.
    Background: Prompt therapy with high-dose intravenous benzylpenicillin for a prolonged period is critical for neurosyphilis patients to avoid irreversible sequelae. However, life-threatening neutropenia has been reported as a complication of prolonged therapy with high doses of benzylpenicillin when treating other diseases. This study aimed to investigate the incidence, presentation, management and prognosis of benzylpenicillin-induced neutropenia in treating neurosyphilis based on a large sample of syphilis patients in Shanghai. Read More

    Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively.
    PLoS Negl Trop Dis 2017 Mar 6;11(3):e0005434. Epub 2017 Mar 6.
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    Background: Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan. Read More

    DIAGNOSIS OF ENDOCRINE DISEASE: Expanding the cause of hypopituitarism.
    Eur J Endocrinol 2017 Jun 3;176(6):R269-R282. Epub 2017 Mar 3.
    School of MedicineUniversity of Belgrade, Belgrade, Serbia
    Hypopituitarism is defined as one or more pituitary hormone deficits due to a lesion in the hypothalamic-pituitary region. By far, the most common cause of hypopituitarism associated with a sellar mass is a pituitary adenoma. A high index of suspicion is required for diagnosing hypopituitarism in several other conditions such as other massess in the sellar and parasellar region, brain damage caused by radiation and by traumatic brain injury, vascular lesions, infiltrative/immunological/inflammatory diseases (lymphocytic hypophysitis, sarcoidosis and hemochromatosis), infectious diseases and genetic disorders. Read More

    Predictors and incidence of sexually transmitted Hepatitis C virus infection in HIV positive men who have sex with men.
    BMC Infect Dis 2017 Mar 2;17(1):185. Epub 2017 Mar 2.
    Melbourne Sexual Health Centre, Alfred Health, Melbourne Australia and Central Clinical School, Monash University, Melbourne, Australia.
    Background: Sexual transmission of Hepatitis C virus (HCV) in men who have sex with men (MSM) and its interaction with HIV status, sexually transmitted infections and sexual behaviour is poorly understood. We assessed the incidence and predictors of HCV infection in HIV positive MSM.

    Methods: The electronic medical record and laboratory results from HIV positive MSM in care at a large urban public specialist HIV clinic embedded in a sexual health centre in Melbourne Australia were collected. Read More

    Molecular typing of Treponema pallidum isolates from Buenos Aires, Argentina: Frequent Nichols-like isolates and low levels of macrolide resistance.
    PLoS One 2017 24;12(2):e0172905. Epub 2017 Feb 24.
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    A total of 54 clinical samples, including genital lesion swabs, whole blood and cerebrospinal fluid from patients diagnosed with syphilis were collected in 2006 and in 2013 in Buenos Aires, Argentina. Treponemal DNA was detected in 43 of the analyzed samples (79.6%) and further analyzed using Sequencing-based molecular typing (SBMT) and Enhanced CDC-typing (ECDCT). Read More

    Late-stage parenchymatous neurosyphilis presenting as general paresis of insane, Poland – case report
    Przegl Epidemiol 2016;70(4):585-592
    WHO Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
    We describe a very rare case of late-stage parenchymatous neurosyphilis, presenting as general paresis of insane, diagnosed in a 44-year-old male truck driver. Probable place of exposition was Belarus. An appropriate clinical examination, laboratory diagnostics, and subsequent effective treatment and follow-up in accordance with evidence-based management guidelines are essential to avoid irreversible sequelae in these late-stage neurosyphilis patients. Read More

    Seroprevalence of hepatitis B, hepatitis C, human immunodeficiency virus, Treponema pallidum, and co-infections among blood donors in Kyrgyzstan: a retrospective analysis (2013-2015).
    Infect Dis Poverty 2017 Feb 21;6(1):45. Epub 2017 Feb 21.
    TWINCORE, Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625, Hannover, Germany.
    Background: Post-Soviet Kyrgyzstan has experienced a major surge in blood-borne infections, but data from adequately powered, up-to-date studies are lacking. We thus examined a) the seroprevalences of hepatitis B virus surface antigen (HBsAg), HIV-1 p24 antigen and antibodies against hepatitis C virus (anti-HCV), human immunodeficiency viruses (anti-HIV-1/2, HIV-1 group O), and Treponema pallidum among blood donors in Kyrgyzstan and assess their distribution according to sex, age, and provinces of residence; b) trends in the respective seroprevalences; and c) co-infection rates among the pathogens studied.

    Methods: Serological screening was performed on 37 165 blood donors at the Republican Blood Centre in Bishkek, Kyrgyzstan, between January 2013 and December 2015. Read More

    Concurrent central nervous system infective pathology in a severely immunocompromised patient.
    J Family Med Prim Care 2016 Jul-Sep;5(3):685-687
    Department of Internal Medicine, Interfaith Medical Center, Brooklyn, New York, USA.
    To our knowledge and literature search, concurrent cryptococcal meningitis and neurosyphilis in a patient have rarely been reported. Here, we report a 37-year-old male with HIV infection presented with headache and dizziness for 5 days along with memory difficulty and personality changes for about 1 week. During the hospital stay, cryptococcal meningitis was confirmed with positive cerebral spinal fluid (CSF) cryptococcal antigen titer (1:320) and positive CSF culture. Read More

    An In Silico Identification of Common Putative Vaccine Candidates against Treponema pallidum: A Reverse Vaccinology and Subtractive Genomics Based Approach.
    Int J Mol Sci 2017 Feb 14;18(2). Epub 2017 Feb 14.
    Department of Immunology, Microbiology and Parasitology, Institute of Biological Sciences and Natural Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba 38025-180, MG, Brazil.
    Sexually transmitted infections (STIs) are caused by a wide variety of bacteria, viruses, and parasites that are transmitted from one person to another primarily by vaginal, anal, or oral sexual contact. Syphilis is a serious disease caused by a sexually transmitted infection. Syphilis is caused by the bacterium Treponema pallidum subspecies pallidum. Read More

    HIV and STI s among men who have sex with men in Dodoma municipality, Tanzania: a cross-sectional study.
    Sex Transm Infect 2017 Aug 15;93(5):314-319. Epub 2017 Feb 15.
    Department of Behavioural Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
    Objectives: To determine the seroprevalence of HIV, STI and related risks among men who have sex with men (MSM) in Dodoma municipality, Tanzania.

    Methods: A cross-sectional study using respondent-driven sampling was employed to recruit study participants aged 18 years and above. Data on sociodemographics, HIV/STI knowledge and sexual practices were collected. Read More

    Single Dose Versus 3 Doses of Intramuscular Benzathine Penicillin for Early Syphilis in HIV: A Randomized Clinical Trial.
    Clin Infect Dis 2017 03;64(6):759-764
    Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
    Background: Patients coinfected with syphilis and human immunodeficiency virus (HIV) may have a slower decrease in rapid plasma reagin (RPR) titers. Currently a single dose of 2.4 million units of intramuscular benzathine penicillin G (BPG) is recommended for the treatment of early syphilis. Read More

    Yaws Osteoperiostitis Treated with Single-Dose Azithromycin.
    Am J Trop Med Hyg 2017 May 13;96(5):1039-1041. Epub 2017 Feb 13.
    Barcelona Institute for Global Health, Hospital Clínic, University of Barcelona, Barcelona, Spain.
    AbstractThe etiologic agent of yaws, Treponema pallidum subsp. pertenue, causes a multistage infection transmitted by nonsexual contact with the exudates from active lesions. Bone lesions in the form of osteoperiostitis are common and occur in numerous bones simultaneously in early stages. Read More

    A Brief Resolved Unexplained Event and Congenital Neurosyphilis.
    Pediatr Ann 2017 Feb;46(2):e61-e64
    Brief resolved unexplained event (BRUE) is a common pediatric problem that presents to ambulatory and emergency settings. Infants presenting with a BRUE can be separated into low- and high-risk groups per recent guidelines. Most low-risk infants who present with a BRUE can be discharged home with anticipatory guidance and education provided to the caregivers; however, high-risk infants should undergo further testing and observation to determine the cause of their event. Read More

    Infectious Diseases and Immunizations in International Adoption.
    Pediatr Ann 2017 Feb;46(2):e56-e60
    Children who are adopted internationally have an increased risk of infectious diseases due to endemic conditions and variable access to preventive health care, such as vaccines, in their country of origin. Pediatricians and other providers who care for children should be familiar with the recommended screening for newly arrived international adoptees. Testing for gastrointestinal pathogens, tuberculosis, hepatitis, syphilis, and HIV should be routinely performed. Read More

    [CXCL-13 as a biomarker in the diagnostics of neuroborreliosis].
    Nervenarzt 2017 Jun;88(6):635-641
    Abteilung für Neurologie, Universitätsklinikum St. Pölten, KLPU, Propst Führer-Straße 4, 3100, St. Pölten, Österreich.
    Background: The chemokine CXCL-13 is a potential intrathecal biomarker for neuroborreliosis (NB). According to the literature the sensitivity of CXCL-13 in the diagnostics of NB varies between 88% and 100% and the specificity between 63% and 99.7%. Read More

    Risk Factors for Incidence of Sexually Transmitted Infections Among Women in a Human Immunodeficiency Virus Chemoprevention Trial: VOICE (MTN-003).
    Sex Transm Dis 2017 Mar;44(3):135-140
    From the *University of Zimbabwe-University of California San Francisco Research Program, Harare, Zimbabwe; †SCHARP at Fred Hutchinson Cancer Research Center; ‡Department of Biostatistics, University of Washington, Seattle, WA; §Magee-Women's Research Institute, Pittsburgh, PA; ¶Medical Research Council, HIV Prevention Research Unit, Durban, South Africa; ∥CAPRISA-University of KwaZulu Natal, Durban, South Africa; **MU-JHU Research Collaboration, Kampala, Uganda; ††Division of AIDS/NIAID/US National Institutes of Health, Bethesda, MD; ‡‡University of Pittsburgh, Pittsburgh, PA; and §§University of Alabama at Birmingham, AL.
    Background: In sub-Saharan Africa, there are limited data on the incidence of sexually transmitted infections (STIs) among women, largely because routine screening for asymptomatic infection is not performed. We conducted a secondary analysis to measure STI incidence rates and determine risk factors for new STI acquisition among women enrolled in the VOICE trial.

    Methods: We analyzed data from 4843 women screened for chlamydia, gonorrhoea, syphilis, and trichomonas infection at baseline, annually, at interim visits when clinically indicated and at their study termination visit. Read More

    Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.
    Protein Sci 2017 Apr 23;26(4):847-856. Epub 2017 Mar 23.
    Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390.
    The spirochete Treponema pallidum is the causative agent of syphilis, a sexually transmitted infection of major global importance. Other closely related subspecies of Treponema also are the etiological agents of the endemic treponematoses, such as yaws, pinta, and bejel. The inability of T. Read More

    The Great Pox and the Surgeon's Role in the Sixteenth Century.
    J Hist Med Allied Sci 2017 01;72(1):21-33
    The sixteenth century saw a shift in perceptions of the scope of surgery. The medieval focus on elevating the status of surgery had been accompanied by a certain distancing of surgery from manual operations, but the medical humanism of the sixteenth century embraced manual skills as an important part of medicine, most noticeably in the case of anatomy. In the first part of this paper I use accounts of the treatment of ulcers as a way of exploring these changes in perceptions. Read More

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