28,387 results match your criteria Endemic Syphilis


High rate of seromarkers for HIV, HBV and syphilis among blood donors using confidential unit exclusion, before and after HIV-NAT implementation at a major public blood bank in the Brazilian Amazon.

Transfusion 2018 Nov 30. Epub 2018 Nov 30.

Tropical Pathology and Public Health Institute, Federal University of Goias, Goiania, Brazil.

Background: Confidential unit exclusion (CUE) was introduced in the 1980's as an additional layer to blood safety, before highly specific and sensitive nucleic acid tests (NAT) for HIV were implemented. The utility of CUE-use in settings that have implemented NAT should be evaluated over time.

Study Design, Methods: Cross-sectional retrospective study carried out from June 2010-November 2015, at Manaus Hemocenter (HEMOAM), Amazonas, Brazil that implemented HIV-NAT in 2012. Read More

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http://dx.doi.org/10.1111/trf.15045DOI Listing
November 2018
1 Read

Syphilis prevalence and risk factors among young men presenting to the Brazilian Army in 2016: Results from a national survey.

Medicine (Baltimore) 2018 Nov;97(47):e13309

Department of Surveillance, Prevention and Control of STI, HIV/AIDS and Viral Hepatitis, Secretariat of Health Surveillance, Ministry of Health of Brazil, Brasília, DF, Brazil.

The Conscripts Survey has been conducted periodically by the Brazilian Department of Sexually Transmitted Infections (STIs), AIDS, and Viral Hepatitis (DIAHV) in collaboration with the Brazilian Ministry of Defense for over 2 decades. It aims to assess the syphilis prevalence and obtain data on knowledge regarding STIs and their risk factors among conscripts enlisted for the Brazilian Army.This cross-sectional study was conducted among conscripts across Brazil aged 17 to 22 years from August to December 2016. Read More

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http://dx.doi.org/10.1097/MD.0000000000013309DOI Listing
November 2018
4 Reads
5.723 Impact Factor

Forty cases of acquired oral syphilis and a review of the literature.

Int J Oral Maxillofac Surg 2018 Nov 17. Epub 2018 Nov 17.

Diagnostic Centre for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, RS, Brazil.

The aim of this study was to describe 40 cases of acquired oral syphilis (AOS) and to discuss the distribution of demographic characteristics, clinical features, and differential diagnosis of the disease. A retrospective study was conducted covering a 17-year period at a single institution in southern Brazil. Moreover, a literature review was performed through a search of the PubMed database for articles on AOS published between 1955 and March 2018. Read More

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http://dx.doi.org/10.1016/j.ijom.2018.10.023DOI Listing
November 2018
2 Reads

Lack of antiretroviral therapy is associated with higher risk of neurosyphilis among HIV-infected patients who remain serofast after therapy for early syphilis.

Medicine (Baltimore) 2018 Nov;97(45):e13171

Department of Dermatology.

Resolution of clinical symptoms and at least 4-fold decline in nontreponemal antibody titers after treatment of syphilis is regarded as "proof of cure." However, a substantial proportion of patients demonstrates <4-fold reduction of titers after recommended therapy (serofast state). It remains unclear whether the serofast state is indicative of persistence of bacteria or only a residual immune response. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0007
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http://dx.doi.org/10.1097/MD.0000000000013171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250445PMC
November 2018
10 Reads

First Paleogenetic Evidence of Probable Syphilis and Treponematoses Cases in the Brazilian Colonial Period.

Biomed Res Int 2018 10;2018:8304129. Epub 2018 Oct 10.

Laboratório de Biologia de Tripanosomatídeos (LABTRIP), Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil.

Despite interest in the origins of syphilis, paleopathological analysis has not provided answers, and paleogenetic diagnosis remains a challenge. Even venereal syphilis has low infectivity which means there are few circulating bacteria for most of the individual's life. Human remains recovered from the Nossa Senhora do Carmo Church (17th to 19th centuries) and the Praça XV Cemetery (18th to 19th centuries), Rio de Janeiro, Brazil, were subjected to paleogenetic analysis. Read More

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http://dx.doi.org/10.1155/2018/8304129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199871PMC
October 2018
2 Reads

Prevalence of Plasmodium parasitaemia in blood donors and a survey of the knowledge, attitude and practices of transfusion malaria among health workers in a hospital in Kumasi, Ghana.

PLoS One 2018 5;13(11):e0206303. Epub 2018 Nov 5.

Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Malaria is one of the transfusion transmissible infections in malaria endemic countries such as Ghana. Healthy blood donors may harbour Plasmodium parasites without showing signs of malaria. Blood from such donors constitutes a risk to transfusion recipients and the recipients of this blood may go on to develop transfusion transmitted malaria (TTM). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206303PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218034PMC
November 2018
7 Reads

Epidemiology of HIV, syphilis, and hepatitis B and C among manual cane cutters in low-income regions of Brazil.

BMC Infect Dis 2018 Nov 3;18(1):546. Epub 2018 Nov 3.

Faculty of Nursing, Federal University of Goias/Universidade Federal de Goiás, Goiânia, GO, Brazil.

Background: In recent decades the epidemic of asymptomatic sexually transmitted infections has extended deep into Brazil, including small towns and rural areas. The purpose of this study was to investigate the epidemiology of HIV, syphilis, and hepatitis B (HBV) and hepatitis C viruses (HCV), and to evaluate immunization coverage against hepatitis B in a group of rural workers in Brazil.

Methods: In 2016, a cross-sectional study was conducted with 937 manual sugarcane cutters of the Midwest and Northeast Regions of Brazil. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3439-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215621PMC
November 2018
3 Reads

Comparison of three syphilis algorithms in West China.

Clin Chim Acta 2019 Jan 31;488:76-80. Epub 2018 Oct 31.

Division of Clinical microbiology, Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, PR China. Electronic address:

Objective: The study was designed to analyze three different algorithms with the implementation of treponemal tests for detecting suspected syphilis in west China where no syphilis algorithms guideline exists.

Methods: We retrospectively collected data to reanalyze three syphilis testing algorithms: the classical reverse algorithm, and two options of syphilis screening in European syphilis guideline. The kappa (κ) coefficients were used to compare the concordance between algorithms using different syphilis assays during two periods. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981183056
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http://dx.doi.org/10.1016/j.cca.2018.10.038DOI Listing
January 2019
2 Reads

Prevalence and risk factors of HTLV-1/2 and other blood borne infectious diseases among blood donors in Yaounde Central Hospital, Cameroon.

Pan Afr Med J 2018 13;30:125. Epub 2018 Jun 13.

Department of Medical Microbiology and Immunology, School of Health Sciences-Catholic University of Central Africa, Yaoundé Cameroon.

Introduction: Transfusion-transmissible infectious microorganisms including bacteria and viruses are among the greatest threats to blood safety for the recipient. The prevalence and risk factors of HTLV-1/2 and other blood borne infectious diseases were determined among blood donors in Yaounde Central Hospital, Cameroon.

Methods: Design: cross sectional study. Read More

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http://www.panafrican-med-journal.com/content/article/30/125
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http://dx.doi.org/10.11604/pamj.2018.30.125.14802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201601PMC
November 2018
3 Reads

Associations between digital dermatitis lesion grades in dairy cattle and the quantities of four Treponema species.

Vet Res 2018 Oct 29;49(1):111. Epub 2018 Oct 29.

Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.

Digital dermatitis (DD) presents as painful, ulcerative or proliferative lesions that lead to bovine lameness affecting economic efficiency and animal welfare. Although DD etiological agent(s) have not been established, it is widely accepted that DD is a polymicrobial disease significantly associated with species of Treponema and the non-linear disease progression may be attributed to interactions among infecting bacteria. We postulated the morphological changes associated with DD lesion grades are related to interactions among infecting species of Treponema. Read More

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https://veterinaryresearch.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13567-018-0605-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206660PMC
October 2018
9 Reads

Syphilitic Alopecia.

N Engl J Med 2018 Oct;379(17):1657

Hospital of the University of Pennsylvania, Philadelphia, PA

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http://dx.doi.org/10.1056/NEJMicm1804118DOI Listing
October 2018

HIV test uptake and related factors amongst heterosexual drug users in Shandong province, China.

PLoS One 2018 18;13(10):e0204489. Epub 2018 Oct 18.

Department of STI and Leprosy Prevention and Control, Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China.

Background: In China, the mode of HIV transmission and the types and routes of drug use have changed in the past decade. HIV testing amongst drug users needs further improvement.

Methods: Interviewer-administered questionnaires were used for data collection amongst 600 heterosexual drug users from the community and a municipal detention centre, where criminal suspects are supervised. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204489PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193625PMC
October 2018
4 Reads

Congenital syphilis in the USA.

Authors:
The Lancet

Lancet 2018 10;392(10154):1168

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http://dx.doi.org/10.1016/S0140-6736(18)32360-2DOI Listing
October 2018
1 Read

Factors Contributing to Congenital Syphilis Cases - New York City, 2010-2016.

MMWR Morb Mortal Wkly Rep 2018 Oct 5;67(39):1088-1093. Epub 2018 Oct 5.

Congenital syphilis occurs when syphilis is transmitted from a pregnant woman to her fetus; congenital syphilis can be prevented through screening and treatment during pregnancy. Transmission to the fetus can occur at any stage of maternal infection, but is more likely during primary and secondary syphilis, with rates of transmission up to 100% at these stages (1). Untreated syphilis during pregnancy can cause spontaneous abortion, stillbirth, and early infant death. Read More

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http://www.cdc.gov/mmwr/volumes/67/wr/mm6739a3.htm?s_cid=mm6
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http://dx.doi.org/10.15585/mmwr.mm6739a3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171893PMC
October 2018
13 Reads

A high burden of asymptomatic genital tract infections undermines the syndromic management approach among adolescents and young adults in South Africa: implications for HIV prevention efforts.

BMC Infect Dis 2018 Oct 3;18(1):499. Epub 2018 Oct 3.

Perinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Youth in southern Africa, particularly adolescent girls and young women, are a key population for HIV prevention interventions. Untreated genital tract infections (GTIs) increase both HIV transmission and acquisition risks. South African GTI treatment guidelines employ syndromic management, which relies on individuals to report GTI signs and symptoms. Read More

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http://dx.doi.org/10.1186/s12879-018-3380-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171143PMC
October 2018
1 Read

Syphilis reinfection is associated with an attenuated immune profile in the same individual: a prospective observational cohort study.

BMC Infect Dis 2018 Sep 25;18(1):479. Epub 2018 Sep 25.

Immunology Unit, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Ascertaining if the clinical and immunological response to repeat syphilis differs from that in initial syphilis may assist in designing optimal syphilis screening strategies and vaccine design.

Methods: We prospectively recruited 120 patients with a new diagnosis of (baseline) syphilis. During a 24-month follow-up period, 11 of these patients had a further diagnosis of (repeat) syphilis. Read More

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http://dx.doi.org/10.1186/s12879-018-3399-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156855PMC
September 2018
1 Read

Public health response to large influx of asylum seekers: implementation and timing of infectious disease screening.

BMC Public Health 2018 Sep 24;18(1):1139. Epub 2018 Sep 24.

Department of Health Security, Infectious Disease Control and Vaccinations Unit, National Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.

Background: Infectious disease screening of migrants at increased risk is a feature of national infection prevention and control measures. Asylum seekers in Finland are offered screening of tuberculosis (TB), hepatitis B, human immunodeficiency virus infection (HIV) and syphilis based on individual risk assessment. We aimed to evaluate the public health response to a large influx of asylum seekers to Finland in 2015-2016 with respect to national guidelines on initial health services and infectious disease screening. Read More

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http://dx.doi.org/10.1186/s12889-018-6038-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154941PMC
September 2018

Improvement of reverse sequence algorithm for syphilis diagnosis using optimal treponemal screening assay signal-to-cutoff ratio.

PLoS One 2018 13;13(9):e0204001. Epub 2018 Sep 13.

Centre hospitalier de l'Université de Montréal, Département de microbiologie médicale et infectiologie, Montréal, Québec, Canada.

Background: Although reverse sequence algorithms (RSA) for syphilis screening are performing well, they still have to rely on treponemal confirmatory tests at least for sera reactive by enzyme immunoassay/chemiluminescence immunoassay (EIA/CIA) and unreactive by rapid plasma reagin (RPR). Quebec's laboratory network previously showed that 3.3% of EIA/CIA reactive and weakly-reactive RPR samples (RPR titer of 1 to 4) would have been misclassified as syphilis cases if a treponemal confirmatory test had not been performed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204001PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136794PMC
September 2018
1 Read

Screening for Syphilis Infection in Pregnant Women: US Preventive Services Task Force Reaffirmation Recommendation Statement.

JAMA 2018 09;320(9):911-917

Tufts University, Medford, Massachusetts.

Importance: Untreated syphilis infection in pregnant women can be transmitted to the fetus (congenital syphilis) at any time during pregnancy or at birth. Congenital syphilis is associated with stillbirth, neonatal death, and significant morbidity in infants (eg, bone deformities and neurologic impairment). After a steady decline from 2008 to 2012, cases of congenital syphilis markedly increased from 2012 to 2106, from 8. Read More

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http://dx.doi.org/10.1001/jama.2018.11785DOI Listing
September 2018
1 Read

Screening for Syphilis Infection in Pregnant Women: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.

JAMA 2018 09;320(9):918-925

Kaiser Permanente Research Affiliates Evidence-based Practice Center, Center for Health Research, Kaiser Permanente, Portland, Oregon.

Importance: The incidence of syphilis and congenital syphilis in the United States has increased after reaching historic lows in the early 2000s.

Objective: To systematically review literature on the effectiveness and harms of screening for syphilis in pregnancy and the harms of penicillin treatment in pregnancy to inform the US Preventive Services Task Force.

Data Sources: MEDLINE, PubMed, and the Cochrane Central Register of Controlled Trials for relevant English-language literature, published from January 1, 2008, to June 2, 2017. Read More

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http://dx.doi.org/10.1001/jama.2018.7769DOI Listing
September 2018
1 Read

Screening for Syphilis in Pregnant Women.

Authors:
Jill Jin

JAMA 2018 09;320(9):948

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http://dx.doi.org/10.1001/jama.2018.12119DOI Listing
September 2018
4 Reads

Opportunistic ocular infections in the setting of HIV.

Curr Opin Ophthalmol 2018 Nov;29(6):558-565

Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Thailand.

Purpose Of Review: The aim of this review is to highlight recent changes in opportunistic ocular infections (OOIs) in the era of modern combination antiretroviral therapy (cART), in the setting of HIV-infected patients.

Recent Findings: Improvements in modern cART has led to a progressive decline in the incidence of OOIs and mortality among patients with AIDS. Not only has there been a decreasing incidence of cytomegalovirus (CMV) retinitis, but there also has been a decline in progression of such retinitis when it does occur in AIDS patients, since the introduction of cART. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000531DOI Listing
November 2018
9 Reads

Hidden dangers-prevalence of blood borne pathogens, hepatitis B, C, HIV and syphilis, among blood donors in Sierra Leone in 2016: opportunities for improvement: a retrospective, cross-sectional study.

Pan Afr Med J 2018 18;30:44. Epub 2018 May 18.

Department of Psychological Medicine and Mental Health, School of Medicine, University of Health and Allied Sciences, PMB 31, Ho, Ghana.

Introduction: Transmissible blood-borne infections are a serious threat to blood transfusion safety in West African countries; and yet blood remains a key therapeutic product in the clinical management of patients. Sierra Leone screens blood donors for blood-borne infections but has not implemented prevention of mother-to-child transmission for hepatitis B. This study aimed to describe the overall prevalence of hepatitis B and C, HIV and syphilis among blood donors in Sierra Leone in 2016 and to compare the differences between volunteer versus family replacement donors, as well as urban versus rural donors. Read More

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http://www.panafrican-med-journal.com/content/article/30/44/
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http://dx.doi.org/10.11604/pamj.2018.30.44.14663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110571PMC
September 2018
5 Reads

Snail track ulcers of the tongue.

Pan Afr Med J 2018;30:23. Epub 2018 May 15.

Dermatology Division, Department of Medical Clinics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

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http://dx.doi.org/10.11604/pamj.2018.30.23.14118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110555PMC
October 2018
2 Reads

[Temporal trend and spatial distribution of congenital syphilis in the state of Rio Grande do Sul between 2001 and 2012].

Cien Saude Colet 2018 Aug;23(8):2587-2597

Faculdade de Medicina, Universidade Federal do Rio Grande. R. Visconde de Paranaguá 102, Centro. 96203-900 Rio Grande RS Brasil.

The scope of the study was to evaluate the temporal trend and spatial distribution of congenital syphilis (CS) in the state of Rio Grande do Sul. All cases reported by the SINASC/DATASUS between 2001 and 2012 were included. The number of live births was obtained from DATASUS. Read More

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http://dx.doi.org/10.1590/1413-81232018238.25422016DOI Listing

[Evaluation of the level of knowledge about Aids and syphilis among the elderly from a city in the interior of the state of Ceará, Brazil].

Cien Saude Colet 2018 Aug;23(8):2495-2502

Universidade Federal do Ceará. R. Coronel Estanislau Frota s/n, Centro. 62010-560 Sobral CE Brasil.

The scope of this study was to evaluate the knowledge of the elderly about syphilis and AIDS before and after conducting educational activities. Fifty-five individuals participating in a convenience group from territory of Terrenos Novos in Sobral in the State of Ceará were selected. To collect the data, a semi-structured questionnaire about HIV/AIDS and syphilis was used, including general features and information about concept, transmission, prevention, vulnerability and treatment. Read More

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http://dx.doi.org/10.1590/1413-81232018238.10072016DOI Listing

Secondary syphilis presenting as a corymbiform syphilide: case report and review.

Rev Inst Med Trop Sao Paulo 2018 Aug 20;60:e40. Epub 2018 Aug 20.

Universidade Federal do Estado do Rio de Janeiro, Hospital Universitário Gaffrée e Guinle, Centro de Ciências Biológicas e da Saúde, Rio de Janeiro, Rio de Janeiro, Brazil.

It is essential that healthcare providers are familiar with the full spectrum of clinical presentations of syphilis. A rare manifestation of secondary syphilis is the corymbiform (or corymbose) arrangement, in which a central greater papule is surrounded by smaller satellite lesions. Very few reports of corymbiform syphilis are available in current biomedical databases. Read More

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http://dx.doi.org/10.1590/S1678-9946201860040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103325PMC
August 2018
1 Read

Charcot osteoarthropathy of the knee secondary to neurosyphilis: a rare condition managed by a challenging arthrodesis.

BMJ Case Rep 2018 Aug 20;2018. Epub 2018 Aug 20.

Orthopaedic Surgery Department, Centro Hospitalar e Universitário de Coimbra EPE, Coimbra, Portugal.

The Charcot joint or neuropathic osteoarthropathy was first described as an arthritic sequela of neurosyphilis (tabes dorsalis). It results in significant joint destruction and instability. Nowadays, it is a very rare condition and represents a considerable challenge to the orthopaedic surgeon. Read More

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http://dx.doi.org/10.1136/bcr-2018-225337DOI Listing
August 2018
8 Reads

Sexually Transmitted Infections in Pregnant Women: Integrating Screening and Treatment into Prenatal Care.

Paediatr Drugs 2018 Dec;20(6):501-509

Pediatric Infectious Diseases, University of Florida College of Medicine Jacksonville, 841 Prudential Drive, Suite # 1130, Jacksonville, FL, 32207, USA.

Chlamydia, gonorrhea, and syphilis continue to be significant burdens to the health of pregnant women and their children despite easy and effective guidance for screening and treatment. Specific guidelines exist for screening for these infections as well as treatment and follow-up. In this article, we review the epidemiology of chlamydia, gonorrhea, and syphilis. Read More

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http://dx.doi.org/10.1007/s40272-018-0310-4DOI Listing
December 2018

An Update on the Global Epidemiology of Syphilis.

Curr Epidemiol Rep 2018 Mar 19;5(1):24-38. Epub 2018 Feb 19.

David Geffen School of Medicine, University of California Los Angeles, Los Angeles, 90095.

Purpose Of Review: Syphilis continues to cause morbidity and mortality worldwide. While syphilis infection is easily identifiable and treatable, rates of syphilis infection continue to increase among select populations in high-income countries and remain at endemic levels in low- and middle-income counties.

Recent Findings: World Health Organization recommended strategies have led to the dual elimination of mother-to-child transmission of syphilis and HIV in several countries, however outbreaks among select populations need to be adequately addressed. Read More

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http://link.springer.com/10.1007/s40471-018-0138-z
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http://dx.doi.org/10.1007/s40471-018-0138-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089383PMC
March 2018
3 Reads

Infections During Pregnancy.

Prim Care 2018 Sep 9;45(3):567-586. Epub 2018 Jul 9.

Department of Family and Community Medicine, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.

Several infections have unique consequences or considerations in pregnancy. Some common infections such as urinary tract infections, influenza, sexually transmitted diseases, and vaginitis affect pregnant women differently than the general population, can cause pregnancy complications, and require treatments that are safe in pregnancy. Infections such as hepatitis B and C and human immunodeficiency virus can be transmitted vertically and therefore management focuses on decreasing perinatal transmission. Read More

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http://dx.doi.org/10.1016/j.pop.2018.05.013DOI Listing
September 2018
3 Reads

[A brief history of syphilis. The disease through the art and the artist].

Rev Med Liege 2018 Jul;73(7-8):363-369

Service d'Endocrinologie, CHU Sart Tilman, Liège, Belgique.

Considering its strong symbolic connotations and its rich history, syphilis could be regarded as the perfect example of venerian disease. It could also be seen as a representative disease of the whole medical history and the evolution of both medical ways of thinking and curing. In this work we will briefly discuss the history of the syphilitic disease and try to show how this condition has affected the life and works of some of the most famous artists of the 19th century. Read More

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The continuing scourge of congenital syphilis in the face of declining seropositivity: A challenge to control efforts.

Indian J Med Microbiol 2018 Apr-Jun;36(2):295-297

Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

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http://dx.doi.org/10.4103/ijmm.IJMM_18_127DOI Listing
December 2018

Art is long, life is short. Francisco José de Goya y Lucientes (1746-1828), the suffering artist.

Med Hypotheses 2018 Aug 25;117:16-20. Epub 2018 May 25.

Psychiatry Unit, Hospital of Versilia, Lido di Camaiore, Lu, Italy.

Francisco José de Goya y Lucientes is one of the major figures of European art. From royal portraits to bizarre, grotesque illustrations, his legacy demonstrates a tortured genius, generating some of the most compelling art ever produced. His story is also the story of Spain during one of the most tumultuous passages of its history. Read More

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http://dx.doi.org/10.1016/j.mehy.2018.05.017DOI Listing
August 2018
1 Read
1.152 Impact Factor

Comparison of RPR and ELISA with TPHA for the Diagnosis of Syphilis: Implication for Updating Syphilis Point-of-Care Tests in Ethiopia.

J Immunol Res 2018 8;2018:2978419. Epub 2018 Jul 8.

Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, University of Gondar, Gondar, Ethiopia.

Background: Syphilis is a sexually transmitted disease (STD) caused by the spirochete , and it persists to be a major public health problem in Africa, including Ethiopia. Syphilis diagnosis is made by either nontreponemal or treponemal approaches, though in developing countries the diagnosis relies mostly on nonspecific tests due to several reasons. Thus, the objective of this study was to assess the sensitivity, specificity, predictive values, and agreement of rapid plasma reagin (RPR) and enzyme-linked immunosorbent assay (ELISA) with hemagglutination assay (TPHA) as a gold standard for the diagnosis of syphilis. Read More

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http://dx.doi.org/10.1155/2018/2978419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057341PMC
November 2018

[Neurosyphilis with cerebellar ataxia, personality change and cognitive decline one year after onset of cerebral infarction].

Rinsho Shinkeigaku 2018 Aug 31;58(8):499-504. Epub 2018 Jul 31.

Division of Neurology, Department of Internal Medicine.

A 51-year-old man with a cerebral lacunar infarction of the midbrain that had occurred two years before, was transferred from a regional psychiatric hospital with chronic progressive psychiatric symptoms including cognitive decline, irritability and hallucinations. Neurological examinations upon admission revealed cerebellar ataxia including dysarthria, ataxic gait and bilateral intention tremor. Brain FLAIR MRI on day 2 revealed abnormal hyperintense lesions in the bilateral insular cortex and temporal pole. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001170DOI Listing
August 2018
3 Reads

An unusual giant serpiginous lesion of secondary syphilis.

An Bras Dermatol 2018 Jul-Aug;93(4):590-591

Service de Dermatologie, Centre Hospitalier et Universitaire, Angers, France.

Syphilis is a worldwide sexually transmitted infection caused by Treponema pallidum subspecies pallidum. Its association with other STIs, including HIV, demands early diagnosis and immediate treatment of patients. We herein report an unusual serpiginous form of secondary syphilis. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063110PMC
September 2018

Syphilis prevalence trends in adult women in 132 countries - estimations using the Spectrum Sexually Transmitted Infections model.

Sci Rep 2018 Jul 31;8(1):11503. Epub 2018 Jul 31.

Unaffiliated, London, United Kingdom.

We estimated national-level trends in the prevalence of probable active syphilis in adult women using the Spectrum Sexually Transmitted Infections (STI) model to inform program planning, target-setting, and progress evaluation in STI control. The model fitted smoothed-splines polynomial regressions to data from antenatal clinic surveys and screening and representative household surveys, adjusted for diagnostic test performance and weighted by national coverage. Eligible countries had ≥1 data point from 2010 or later and ≥3 from 2000 or later from adult populations considered representative of the general female population (pregnant women or community-based studies). Read More

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http://dx.doi.org/10.1038/s41598-018-29805-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068092PMC

Features of syphilis seropositive pregnant women raising alarms in Hungary, 2013-2016.

Eur J Obstet Gynecol Reprod Biol 2018 Sep 21;228:274-278. Epub 2018 Jul 21.

Femicare Clinical Research for Women, Tienen, Belgium; Department of Obstetrics and Gynaecology, University Hospital Antwerp, Edegem, Belgium.

Objectives: The incidence of syphilis has been on the rise in Hungary over the last decades. We aimed to assess the syphilis seroprevalence in pregnant women during 2013-2016. The secondary aims were to describe seropositivity by age and gestational age, to estimate infectivity rates in different age groups, and to compare the efficacy of mandatory prenatal screening versus individual venereological testing in revealing syphilis. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.07.022DOI Listing
September 2018

Syphilitic meningomyelitis presenting with visceral crisis: A case report.

Medicine (Baltimore) 2018 Jul;97(30):e11661

Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun.

Rationale: We report a rare case of syphilitic meningomyelitis presenting with visceral crisis and possessing characteristic imaging findings.

Patient Concerns: The patient, a 50-year-old woman, complained of pain in the upper abdomen and back. She then developed numbness in both lower extremities and weakness in the left lower limb. Read More

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http://dx.doi.org/10.1097/MD.0000000000011661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078648PMC
July 2018
2 Reads

A second chance.

Authors:
Martin Enserink

Science 2018 Jul;361(6399):216-221

Lihir Island in Papua New Guinea.

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http://dx.doi.org/10.1126/science.361.6399.216DOI Listing
July 2018
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Factors associated with sexually transmitted infections: a population based survey in the city of São Paulo, Brazil.

Cien Saude Colet 2018 Jul;23(7):2423-2432

Programa Municipal de DST/AIDS de São Paulo. R. Santa Cruz 81, Vila Mariana. 04121-000 São Paulo SP Brasil.

We determined the prevalence of sexually transmitted infections (STIs), the factors associated with infection and types of counseling received by men and women from health professionals in the City of São Paulo. The investigation consisted of a cross-sectional study conducted with men and women aged between 15 and 64 years living in the City of São Paulo. Of 4,057 individuals who had engaged in sexual activity, 6. Read More

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http://dx.doi.org/10.1590/1413-81232018237.20602016DOI Listing

State Requirements for Prenatal Syphilis Screening in the United States, 2016.

Matern Child Health J 2018 09;22(9):1227-1232

Division of STD Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS E-02, Atlanta, GA, 30329-4027, USA.

Objectives This study assesses U.S. state laws related to prenatal syphilis screening, including whether these laws align with CDC screening recommendations and include legal penalties for failing to screen. Read More

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http://dx.doi.org/10.1007/s10995-018-2592-0DOI Listing
September 2018
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Acquired Syphilis in a Chinese Family among Three Generations.

Chin Med J (Engl) 2018 Jul;131(14):1761-1762

Department of Dermatopathology, Shanghai Dermatology Hospital, Shanghai 200443, China.

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http://dx.doi.org/10.4103/0366-6999.235888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048926PMC
July 2018
2 Reads

Unusual Manifestations of Secondary Syphilis: Case Presentations.

Acta Dermatovenerol Croat 2018 Jun;26(2):186-188

Sorina Ana Dănescu, MD, University of Medicine and Pharmacy "Iuliu Hatieganu", Victor Babes 8 street, Cluj-Napoca, Cluj, Romania;

Dear Editor, Syphilis is an infection caused by Treponema pallidum. Without treatment, it goes through the following stages: primary, secondary, latent, and tertiary (1). The clinical picture of secondary syphilis is very variable (2,3). Read More

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June 2018
18 Reads

Serological Diagnosis of Syphilis: Preliminary Study Searching for an Algorhitm in Turkey.

Acta Dermatovenerol Croat 2018 Jun;26(2):146-152

Cemile Sonmez, MD, Public Health Institution of Turkey, Microbiology Reference Laboratories, Adnan Saygun Street no:55 Sihhiye, Ankara, Turkey;

Different algorithms have been proposed to increase the diagnostic capacity of syphilis. We analyzed three common algorithms for detecting suspected syphilis cases in low prevelance Turkish population. The study included a total of 340 clinical serum samples from adults throughout Turkey, who had syphilis as a clinical preliminary diagnosis and were positive on at least one of the following tests: Rapid Plasma Reagin (RPR), Treponema pallidum Haemagglutination test (TPHA) and FTA-abs Ig. Read More

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June 2018
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Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series.

Arq Neuropsiquiatr 2018 Jun;76(6):373-380

Universidade Federal do Paraná, Hospital de Clínicas, Departamento de Medicina Interna, Serviço de Neurologia, Curitiba PR, Brasil.

Background: During the first decade of this century, a significant increase in the incidence of syphilis was documented.

Objective: To study clinical and laboratory characteristics of central nervous system and ocular syphilis.

Methods: A retrospective case series of 13 patients with a clinical and laboratory diagnosis of neurosyphilis and/or ocular syphilis who had been admitted to the Neurology and Neuro-ophthalmology Service of the Hospital de Clínicas, Federal University of Paraná. Read More

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http://dx.doi.org/10.1590/0004-282X20180054DOI Listing
June 2018
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Mathematical Assessment of the Role of Early Latent Infections and Targeted Control Strategies on Syphilis Transmission Dynamics.

Acta Biotheor 2018 Jul 3. Epub 2018 Jul 3.

School of Mathematical and Statistical Sciences, Arizona State University, Arizona, USA.

A new multi-stage deterministic model for the transmission dynamics of syphilis, which incorporates disease transmission by individuals in the early latent stage of syphilis infection and the reversions of early latent syphilis to the primary and secondary stages, is formulated and rigorously analysed. The model is used to assess the population-level impact of preventive (condom use) and therapeutic measures (treatment using antibiotics) against the spread of the disease in a community. It is shown that the disease-free equilibrium of the model is globally-asymptotically stable whenever the associated control reproduction number (denoted by [Formula: see text]) is less than unity. Read More

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http://dx.doi.org/10.1007/s10441-018-9336-9DOI Listing

Medical Journals in Bosnia and Herzegovina from 1878 to 1945.

Acta Med Acad 2018 May;47(1):94-101

Clinic for Cardiovascular Surgery, Clinical Center University of Sarajevo, Sarajevo Bosnia and Herzegovina.

This paper presents the medical journals published in Bosnia and Herzegovina (BIH) in the period from 1878 to 1945. The first medical journal in BIH may be deemed to be Jahrbuch des Bosnisch-Hercegowinischen Landesspittales in Sarajevo (The Yearbook of the National Hospital of Bosnia and Herzegovina in Sarajevo). In a special part of this journal, doctors from Austro-Hungary serving in Sarajevo wrote scholarly articles about their patients' various ailments. Read More

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http://dx.doi.org/10.5644/ama2006-124.220DOI Listing
May 2018
1 Read