30,786 results match your criteria Endemic Syphilis


Demographic, Clinical and Laboratory Characteristics of Ocular Syphilis: 6-Years Case Series Study From an Eye Center in East-China.

Front Immunol 2022 10;13:910337. Epub 2022 Jun 10.

Department of Ophthalmology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

Purpose: To report the demographic, clinical, and laboratory characteristics of ocular syphilis based on a 6-year case series study from an eye center in East-China.

Methods: A total of 131 cases (191 eyes) of ocular syphilis and the annual number of total syphilis cases from January 2016 to December 2021, were included in this study. Detailed medical records including systemic and ophthalmic medical history, a complete ophthalmic examination, color fundus photography, B-type ultrasound, fundus fluorescein angiography (FFA), spectral domain optical coherence tomography (SD-OCT), laboratory tests of the serum and cerebrospinal fluid (CSF) samples, as well as visual field test and orbital or cranial MRI in cases with suspected optic neuritis or optic atrophy, were collected and analyzed. Read More

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Increasing incidence rates of sexually transmitted infections from 2010 to 2019: an analysis of temporal trends by geographical regions and age groups from the 2019 Global Burden of Disease Study.

BMC Infect Dis 2022 Jun 26;22(1):574. Epub 2022 Jun 26.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Background: World Health Organization announced its goal of ending sexually transmitted infection (STI) epidemics by 2030. To provide a reference for tailored prevention strategies, we analyzed trends and differences in STIs by geographical regions and age groups from 1990 to 2019.

Methods: Annual number of new infections and age-standardized incidence rates (ASRs) of syphilis, chlamydia, gonorrhea, trichomoniasis, and genital herpes were recorded from the 2019 Global Burden of Disease study. Read More

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Facilitators and barriers to point-of-care testing for sexually transmitted infections in low- and middle-income countries: a scoping review.

BMC Infect Dis 2022 Jun 20;22(1):561. Epub 2022 Jun 20.

Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton, UK.

Background: Sexually transmitted infections (STIs) in low- and middle-income countries (LMICs) are predominantly managed by syndromic management. However, most STIs are asymptomatic. These untreated STIs cause individual morbidity, and lead to high STI prevalences. Read More

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Preconception reproductive tract infections status and adverse pregnancy outcomes: a population-based retrospective cohort study.

BMC Pregnancy Childbirth 2022 Jun 20;22(1):501. Epub 2022 Jun 20.

NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, 400020, Shanghai, China.

Background: Reproductive tract infections can cause serious adverse outcomes for pregnant women such as spontaneous abortion and preterm birth. However, it is unclear whether maternal reproductive tract infection before pregnancy would also be related to any adverse pregnancy outcomes. This study aims to investigate the association of maternal preconception reproductive tract infections with subsequent adverse pregnancy outcomes. Read More

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[Effect of behavioral intervention based on social media to promote HIV/syphilis testing in young men who have sex with men].

Zhonghua Liu Xing Bing Xue Za Zhi 2022 Jun;43(6):892-897

Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518000, China.

To evaluate the effect of social media based behavioral intervention on promoting joint testing of HIV and syphilis in young men who have sex with men (MSM). After the recruitment, the participants who met the inclusion criteria were randomly divided (1∶1) into two groups, i.e. Read More

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Cost-effectiveness analysis of the prevention of mother-to-child transmission of HIV.

Infect Dis Poverty 2022 Jun 15;11(1):68. Epub 2022 Jun 15.

Capital Institute of Pediatrics, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China.

Background: The number of HIV-positive pregnant women accounted for about 10% of China's total over the past few years in Liangshan Prefecture, Sichuan province in China. Although cost-effectiveness of the PMTCT of HIV have been evaluated in other previous studies, no specific study has been conducted in Liangshan prefecture, nor has the expenses paid individually by HIV-positive pregnant women been included. The purpose of this study was to evaluate both the short-term and long-term cost-effectiveness of PMTCT of HIV in Liangshan Prefecture from the social perspective. Read More

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Safe Spaces 4 Sexual Health: A Status-Neutral, Mobile Van, HIV/STI Testing Intervention Using Online Outreach to Reach MSM at High Risk for HIV Acquisition or Transmission.

J Acquir Immune Defic Syndr 2022 Jul;90(S1):S84-S89

Division of Adolescent/Young Adult Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD; and.

Background: Black men who have sex with men (MSM) carry the greatest burden of new HIV diagnoses in the United States. Ending the HIV epidemic requires strategic, culturally specific approaches to target factors contributing to persistent HIV disparities.

Setting: Safe Spaces 4 Sexual Health (SS4SH), a community-informed HIV/sexually transmitted infection (STI) testing strategy combining mobile van testing with online outreach, was implemented over a 14-month period from 2018 to 2019 in Baltimore, MD. Read More

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Whole genome sequences of Treponema pallidum subsp. endemicum isolated from Cuban patients: The non-clonal character of isolates suggests a persistent human infection rather than a single outbreak.

PLoS Negl Trop Dis 2022 Jun 10;16(6):e0009900. Epub 2022 Jun 10.

Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Bejel (endemic syphilis) is a neglected non-venereal disease caused by Treponema pallidum subsp. endemicum (TEN). Although it is mostly present in hot, dry climates, a few cases have been found outside of these areas. Read More

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Proof of an optimized salicylic acid paste-based treatment concept of ulcerative M2-stage digital dermatitis lesions in 21 dairy cows.

PLoS One 2022 9;17(6):e0269521. Epub 2022 Jun 9.

Clinic for Ruminants, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

The efficacy of salicylic acid paste (SA) in the treatment of ulcerative bovine digital dermatitis (BDD) was assessed by combining clinical and histopathological analyses with molecular biological techniques. The latter were conducted in a blinded manner to reach maximum objectivity. Prior to treatment, M2-stage BDD lesions (n = 26, diagnosed in 21 dairy cows) exhibited ulceration, with severe perivascular, chronic, lymphoplasmacytic dermatitis and extensive keratinolysis being noted in most cases. Read More

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Standardised protocol for a prospective cross-sectional multicentre clinical utility evaluation of two dual point-of-care tests in non-clinical settings for the screening of HIV and syphilis in men who have sex with men.

Authors:

BMJ Open 2022 Jun 8;12(6):e055275. Epub 2022 Jun 8.

Introduction: Point-of-care dual tests (POCTs) for simultaneously detecting antibodies to HIV and syphilis (dual HIV-syphilis POCTs) have been developed recently and show encouraging performance compared with the reference tests in laboratory-based studies. As community-based voluntary, counselling and testing (CBVCT) services are effective providers of HIV and syphilis testing and counselling with high acceptability among men who have sex with men (MSM), the evaluation of the utility of these dual tests in CBVCT services is a high priority. This prospective cross-sectional study will conduct a clinical utility evaluation of two dual POCTs in non-clinical settings for the screening of HIV and syphilis in MSM. Read More

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HIV, syphilis, hepatitis B and C in key populations: results of a 10-year cross-sectional study, Southern Brazil.

Einstein (Sao Paulo) 2022 6;20:eAO6934. Epub 2022 Jun 6.

Universidade Federal do Paraná, Curitiba, PR, Brazil.

Objective: Although the development of prevention and treatment strategies for sexually transmitted infections in key groups has improved over the years, they still remain a challenge for health systems worldwide. In this context, the objective of this study is to assess the seroprevalence in the tested population, with an emphasis on key populations, aiming at identifying the participants' profile and consequently the development of testing strategies.

Methods: The present study analyzed the seroprevalence of HIV, syphilis, and hepatitis B and C, and the epidemiological profiles of key and general populations tested at a reference public health facility for sexually transmitted infections testing and counseling in the city of Curitiba, Southern Brazil. Read More

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Characterisation of Treponema pallidum lineages within the contemporary syphilis outbreak in Australia: a genomic epidemiological analysis.

Lancet Microbe 2022 Jun 20;3(6):e417-e426. Epub 2022 Apr 20.

Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Melbourne, VIC, Australia. Electronic address:

Background: The incidence of syphilis has increased markedly in the past decade in high-income countries, including Australia. To date, however, genomic studies of Treponema pallidum have focused mainly on the northern hemisphere. Here, we aimed to characterise the lineages of T pallidum driving the current syphilis epidemic in Australia. Read More

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Impact of COVID-19 pandemic on the epidemiology of STDs in China: based on the GM (1,1) model.

BMC Infect Dis 2022 Jun 4;22(1):519. Epub 2022 Jun 4.

Shanghai Skin Disease Clinical College of Anhui Medical University, Shanghai Skin Disease Hospital, Shanghai, 200050, People's Republic of China.

Background: COVID-19 and Sexually Transmitted Diseases (STDs) are two very important diseases. However, relevant researches about how COVID-19 pandemic has impacted on the epidemiological trend of STDs are limited in China. This study aimed to analyze the impact of COVID-19 on STDs in China and proposed relevant recommendations to be used in bettering health. Read More

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Determinants of syphilis infection among pregnant women attending antenatal care in hospitals of Wolaita zone, Southern Ethiopia, 2020.

PLoS One 2022 3;17(6):e0269473. Epub 2022 Jun 3.

School of Public Health, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.

Objective Of The Study: The objective of this study was to identify determinants of syphilis infection among pregnant women attending antenatal care in hospitals in the Wolaita zone, Southern Ethiopia,2020.

Methods: An unmatched facility-based case-control study was conducted among pregnant women who received antenatal care at four randomly selected hospitals from September 1 to October 30, 2020. A two-stage sampling technique was used in the selection of hospitals and study participants. Read More

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Yaws in the Philippines: A clinico-seroprevalence study of selected communities in Mindanao.

PLoS Negl Trop Dis 2022 06 1;16(6):e0010447. Epub 2022 Jun 1.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Yaws is a chronic, highly contagious skin and bone infection affecting children living in impoverished, remote communities. It is caused by Treponema pallidum subsp. pertenue. Read More

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Development of multiplex HRM-based loop-mediated isothermal amplification method for specific and sensitive detection of Treponema pallidum.

Arch Microbiol 2022 Jun 1;204(6):355. Epub 2022 Jun 1.

Molecular Genetics Laboratory, Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Kanchipuram District, Chennai, Tamil Nadu, 603203, India.

Syphilis is a sexually transmitted disease caused by the spirochaete bacterium Treponema pallidum. This study has developed a multiplex High-Resolution Melt-curve Loop-mediated isothermal amplification (multiplex HRM-LAMP) assay targeting the marker genes polA and tprL to detect T. pallidum. Read More

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Neurosyphilis mimicking giant cell arteritis both clinically and microscopically.

BMJ Case Rep 2022 May 31;15(5). Epub 2022 May 31.

Internal Medicine, Canisius Wilhelmina Hospital, Nijmegen, Gelderland, The Netherlands

Temporal arteritis is usually caused by giant cell arteritis (GCA). However, inflammation of the temporal artery can also occur secondary to autoimmune diseases or infections.We present a remarkable case of a man in his 70s with biopsy proven temporal arteritis, who was later diagnosed with meningovascular neurosyphilis. Read More

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Neurosyphilis Mimicking Behavioral Variant of Frontotemporal Dementia in a 59-Year-Old Man.

Cogn Behav Neurol 2022 06 1;35(2):140-146. Epub 2022 Jun 1.

Unit of Neurology V and Neuropathology, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy.

We present the case of a man exhibiting a clinical phenotype of behavioral variant of frontotemporal dementia (bvFTD). The man had developed psychiatric disturbances with verbal aggressiveness over a few months, followed by cognitive and frontal behavioral disorders, fulfilling the clinical criteria for bvFTD. Atrophy and hypometabolism in frontotemporal regions were consistent with the diagnosis. Read More

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Health Information and Monitoring of Sexually Transmitted Infections (SIM study): a single-center, parallel, three-arm randomized controlled trial protocol for enhancing adherence to syphilis treatment and follow-up.

Trials 2022 May 26;23(1):445. Epub 2022 May 26.

Hospital Moinhos de Vento, Porto Alegre, Brazil.

Background: Syphilis has recently resurfaced as a significant public health problem. Since the 2000s, isolated syphilis outbreaks have increasingly occurred in North America, Europe, and Australia; in Brazil, there have been progressive increases in both congenital and acquired syphilis. There are several possible explanations, such as misdiagnosis of acquired syphilis, which could increase the number of untreated transmitters in the population; failure to initiate or complete treatment; and nontreatment of sexual partners (leading to reinfection). Read More

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Prevalence of and risk factors associated with HIV, Herpes Simplex Virus-type 2, Chlamydia trachomatis and Neisseria gonorrhoeae infections among 18-24 year old students attending Higher Learning Institutions in Mbeya-Tanzania.

PLoS One 2022 26;17(5):e0266596. Epub 2022 May 26.

Department of Epidemiology & Biostatistics, Institute of Public Health, Kilimanjaro Christian Medical University College (KCMUCo), Moshi, Tanzania.

Background: Sexually transmitted infections (STIs) are common among young people in low- and middle-income countries and are associated with negative reproductive and pregnancy outcomes. Most of the studies have assessed HIV among adolescents and young adults, with limited information on occurrence of other STIs in this population. This study aimed to describe the prevalence of and risk factors associated with Herpes Simplex Virus-type 2 (HSV-2), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Syphilis and HIV infection among young adults attending Higher Learning Institutions (HLIs) in Mbeya, Tanzania. Read More

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Yaws elimination in Ecuador: Findings of a serological survey of children in Esmeraldas province to evaluate interruption of transmission.

PLoS Negl Trop Dis 2022 05 25;16(5):e0010173. Epub 2022 May 25.

Instituto de Biomedicina, Carrera de Medicina, Universidad Central, Quito, Ecuador.

Background: The WHO roadmap for neglected tropical diseases includes yaws eradication requiring certification of elimination of transmission in all endemic and formerly endemic countries worldwide. A community-based programme for yaws control was considered to have achieved elimination of the infection in the endemic focus in Ecuador after 1993. We did a serosurvey of children in this focus to provide evidence for interruption of transmission. Read More

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From Syphilis to Sepsis: Pilot Studies and the Importance of Staying Grounded.

Crit Care Med 2022 06 19;50(6):1015-1018. Epub 2022 May 19.

Division of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.

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Coerced syphilis self-testing among men who have sex with men: a nationwide cross-sectional study in China.

BMC Infect Dis 2022 May 23;22(1):485. Epub 2022 May 23.

STD Control Department, Dermatology Hospital, Southern Medical University, Guangzhou, 510095, China.

Background: Syphilis testing uptake remains low among men who have sex with men (MSM) in many low-and middle-income countries. Syphilis self-testing is an efficacious approach on increasing syphilis testing coverage. However, one unintended consequence is the syphilis self-testing coercion from others (including partners, healthcare providers, friends, etc. Read More

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Community engagement on-site rapid test for chlamydia and gonorrhea among men who have sex with men: a pioneering study in Guangzhou, China.

BMC Public Health 2022 May 24;22(1):1036. Epub 2022 May 24.

Department of Sexually Transmitted Diseases, Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.

Background: Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections are prevalent among men who have sex with men (MSM) in China. However, compared to syphilis and HIV, the testing rate for chlamydia and gonorrhea remains low. The purpose of this pilot study was to evaluate the feasibility for conducting rapid nucleic acid test for chlamydia and gonorrhea in MSM community-based organizations (CBO). Read More

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Secondary Syphilis Unmasked by BNT162b2 mRNA COVID-19 Vaccine.

Authors:
Israel Potasman

Isr Med Assoc J 2022 05;24(5):337-338

Internal Medicine and Infectious Diseases, Maccabi Healthcare Services, Haifa, Israel.

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Two Treponema pallidum strains account for the majority of syphilis infections, including among females, in Queensland, Australia.

Commun Dis Intell (2018) 2022 May 19;46. Epub 2022 May 19.

Pathology Queensland Central Laboratory, Brisbane, Queensland, Australia.

Abstract: An ongoing outbreak of syphilis in Australia, first reported in the state of Queensland in 2011, has led to increasing cases of congenital syphilis, including several deaths. Here, we applied multi-locus sequence typing (MLST) on available Treponema pallidum PCR-positive samples from the state of Queensland from the beginning of the outbreak to July 2020. In total, 393 samples from 337 males and 56 females were genotyped. Read More

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[Analysis on psychoactive substances use in men who have sex with men in Tianjin].

Zhonghua Liu Xing Bing Xue Za Zhi 2022 May;43(5):686-691

Department of AIDS/STD Prevention and Control, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.

To understand the use of psychoactive substances and its related factors in men who have sex with men (MSM) in Tianjin. A cross-sectional survey was conducted in MSM recruited in Tianjin by snowball sampling from September 2017 to December 2020, the information about their social demographic information, use of psychoactive substances and behavioral characteristics were collected, meanwhile the blood samples were taken from them for HIV/syphilis detections. Multivariate logistic regression was used to explore related factors about psychoactive substances use. Read More

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