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    Bejel in Cuba: molecular identification of Treponema pallidum subsp. endemicum in patients diagnosed with venereal syphilis.
    Clin Microbiol Infect 2018 Feb 15. Epub 2018 Feb 15.
    Department of Biology, Masaryk University, Brno, 625 00, Czech Republic. Electronic address:
    Objectives: Bejel, caused by Treponema pallidum subsp. endemicum (TEN), was until now considered as a non-venereal disease endemic in areas with hot and dry climates. This study has identified TEN in clinical samples from Cuban patients previously diagnosed with syphilis. Read More

    Syphilis of the lumbar spine: A case report and review of the literature.
    Medicine (Baltimore) 2017 Dec;96(50):e9098
    Department of Orthopedic.
    Rationale: Tertiary syphilis can manifest as gummatous disease, but gumma of the spine has been extremely rarely reported.

    Patient Concerns: A 61-year-old male complained of worsening pain and numbness in both lower legs for four weeks.

    Diagnoses: Syphilis of the Lumbar Spine. Read More

    CXCL13 and TH1/Th2 cytokines in the serum and cerebrospinal fluid of neurosyphilis patients.
    Medicine (Baltimore) 2017 Nov;96(47):e8850
    Department of Neurology.
    Neurosyphilis is a chronic infectious disease with involvement of central nervous system infection by Treponema pallidum. This study was to investigate the contents of B lymphocyte chemokine 1 (BLC-1/chemokine [C-X-C motif] ligand 13), Th1 cytokines (Interleukin [IL]-2, IL-12, and Interferon [IFN]-γ), and Th2 cytokines (IL-6 and IL-10) in serum and cerebrospinal fluid (CSF) of HIV-negative patients with neurosyphilis before and after treatment, aiming to elucidate roles of CXCL13 and Th1/Th2 cytokines in immune response to and pathogenesis of neurosyphilis.Enzyme-linked immunosorbent assay was employed to detect the contents of CXCL13, IL-2, IL-12, IFN-γ, IL-6, and IL-10 in serum and CSF of 47 HIV-negative patients with neurosyphilis, 36 syphilis patients without neurological involvement and 23 controls (noninfectious intracranial disease) before, 3 and 12 months after treatment with high dose penicillin. Read More

    A Non-human Primate Model for Rectally Transmitted Syphilis.
    J Infect Dis 2017 Dec 22. Epub 2017 Dec 22.
    Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
    Men, diagnosed with syphilis or other rectal sexually transmitted infections (STIs), who have sex with men (MSM) are at a higher risk for HIV acquisition, which is concerning given the large increase in recently reported syphilis cases in the United States. We have developed the first non-human primate model for rectally transmitted syphilis by exposing SHIV-infected and naïve rhesus macaques to Treponema pallidum in the rectum. All animals showed mucosal lesions, systemic dissemination, and seroconversion (treponemal antibodies). Read More

    Combined evaluation of sexually transmitted infections in HIV-infected pregnant women and infant HIV transmission.
    PLoS One 2018 5;13(1):e0189851. Epub 2018 Jan 5.
    David Geffen UCLA School of Medicine, Los Angeles, CA, United States of America.
    Background: Sexually transmitted infections (STIs) including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Treponema pallidum (TP), and cytomegalovirus (CMV) may lead to adverse pregnancy and infant outcomes. The role of combined maternal STIs in HIV mother-to-child transmission (MTCT) was evaluated in mother-infant pairs from NICHD HPTN 040.

    Methodology: Urine samples from HIV-infected pregnant women during labor were tested by polymerase chain reaction (PCR) for CT, NG, and CMV. Read More

    Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea.
    PLoS Negl Trop Dis 2017 12 27;11(12):e0006113. Epub 2017 Dec 27.
    Department of Medicine, University of Washington, Seattle, Washington, United States of America.
    Background: Yaws is a neglected tropical disease, caused by Treponema pallidum subsp. pertenue. The disease causes chronic lesions, primarily in young children living in remote villages in tropical climates. Read More

    Clinical Profile and Outcomes of Optic Neuritis in an HIV Prevalent Urban Community in South Africa.
    Middle East Afr J Ophthalmol 2017 Jul-Sep;24(3):131-135
    Division of Ophthalmology, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa.
    Purpose: To determine the clinical profile, causes and response to corticosteroid therapy in patients admitted and treated for optic neuritis at a tertiary hospital in Cape Town, South Africa.

    Methods: A retrospective case review of 117 patients with optic neuritis between January 2002 and December 2012. Demographic information, clinical presentation, course of illness, investigations performed and visual outcomes at discharge and at three month follow up were collected for analysis. Read More

    Between Colonial, National, and International Medicine: The Case of Bejel.
    Bull Hist Med 2017 ;91(4):744-771
    In the 1920s and 1930s, doctors stationed in the Middle East and North Africa debated whether bejel, a form of endemic syphilis, was an Arab version of syphilis, or a separate disease altogether. Using their clinical experience in the region, they tried to weave this unfamiliar phenomenon into a civilizational narrative, which placed European civilization at the top of a hierarchy. The assumption was that there was something inherent to Islamic societies and their hygienic habits that accounted for this difference. Read More

    The Etiology of Genital Ulcer Disease and Coinfections With Chlamydia trachomatis and Neisseria gonorrhoeae in Zimbabwe: Results From the Zimbabwe STI Etiology Study.
    Sex Transm Dis 2018 Jan;45(1):61-68
    From the *Zimbabwe Ministry of Health and Child Care; †Department of Community Medicine, University of Zimbabwe, College of Health Sciences, Harare, Zimbabwe; ‡US Centers for Disease Control and Prevention, Zimbabwe and Division of Global HIV/AIDS, CDC, Atlanta, GA; §Fogarty International Center, National Institutes of Health, Bethesda, MD; ¶Zimbabwe Community Health Intervention Research (ZiCHIRe) Project, Harare, Zimbabwe; ∥Western Sydney Sexual Health Centre, Parramatta; **Marie Bashir Institute for Infectious Diseases and Biosecurity & Sydney Medical School-Westmead, University of Sydney, Sydney, New South Wales, Australia; ††School of Medicine, University of Washington, Seattle, WA; ‡‡Colorado School of Public Health, University of Colorado Denver, Denver, CO; §§Rietmeijer Consulting LLC, Denver, CO.
    Background: In many countries, sexually transmitted infections (STIs) are treated syndromically. Thus, patients diagnosed as having genital ulcer disease (GUD) in Zimbabwe receive a combination of antimicrobials to treat syphilis, chancroid, lymphogranuloma venereum (LGV), and genital herpes. Periodic studies are necessary to assess the current etiology of GUD and assure the appropriateness of current treatment guidelines. Read More

    Evaluation of seven rapid tests for syphilis available in Brazil using defibrinated plasma panels.
    Sex Transm Infect 2017 Dec;93(S4):S46-S50
    Department of Surveillance, Prevention and Control of Sexually Transmitted Infections, HIV/AIDS and Viral Hepatitis, Secretariat of Health Surveillance, Ministry of Health, Setor Administrativo Federal Sul, Brasília, Distrito Federal, Brazil.
    Objectives: In 2012, the WHO estimated that 6 million new cases of syphilis per year would occur worldwide, including 937 000 in Brazil. Early diagnosis and treatment of syphilis are essential to reduce morbidity and prevent transmission. The availability of rapid tests (RTs) for this diagnosis means that testing can be performed more quickly, as a point-of-care test, even in non-laboratory environments and requires only simple technical training to antibodies detection. Read More

    Subacute loss of vision in one eye · rash on hands and feet · plaques with scaling on genitals · Dx?
    J Fam Pract 2017 Dec;66(12):E9-E11
    Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA.
    A 67-year-old man presented to the hospital with subacute loss of vision in his left eye. The visual changes began 2 weeks earlier, with a central area of visual loss that had since progressed to near complete vision loss in the left eye. Physical examination revealed patchy alopecia, a scaling and hyperkeratotic rash of his hands and feet, and blanching, erythematous plaques with associated scaling on the scrotum and glans penis. Read More

    Pathogen reduction and blood transfusion safety in Africa: strengths, limitations and challenges of implementation in low-resource settings.
    Vox Sang 2018 Jan 30;113(1):3-12. Epub 2017 Nov 30.
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Transfusion-transmitted infection risk remains an enduring challenge to blood safety in Africa. A high background incidence and prevalence of the major transfusion-transmitted infections (TTIs), dependence on high-risk donors to meet demand, suboptimal testing and quality assurance collectively contribute to the increased risk. With few exceptions, donor testing is confined to serological evaluation of human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) and syphilis. Read More

    VITREOUS TREPONEMAL ANTIBODY AS A SUPPLEMENTARY TEST TO SEROLOGY FOR THE CONFIRMATION OF SYPHILITIC CHORIORETINITIS.
    Retin Cases Brief Rep 2017 Nov 22. Epub 2017 Nov 22.
    Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts.
    Purpose: To report the novel application of nontreponemal and treponemal antibody to confirm diagnosis of ocular syphilis from vitreous samples.

    Methods: Two distinct case reports emphasizing the importance of confirmatory vitreous treponemal antibody. Multimodal imaging of patients was also applied. Read More

    Prevalence of syphilis and HIV infection during pregnancy in incarcerated women and the incidence of congenital syphilis in births in prison in Brazil.
    Cad Saude Publica 2017 Nov 21;33(11):e00183616. Epub 2017 Nov 21.
    Sorbonne Universités, UPMC Univ Paris 06, INSERM, IPLESP UMRS 1132, F75012 Paris, France.
    This study aimed to estimate the prevalence of syphilis and HIV infection during pregnancy, the mother to child transmission of syphilis and the incidence of congenital syphilis in incarcerated women in Brazil; to compare these rates to those observed in pregnant women outside of jail; and to verify the maternal factors associated with syphilis infection during pregnancy in free and incarcerated women. We used data from two nationwide studies conducted during the period 2011-2014. The Birth in Brazil study included 23,894 free women cared for in 266 hospitals. Read More

    Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study.
    BMJ 2017 Nov 21;359:j5018. Epub 2017 Nov 21.
    National Institute of Population Medical Genetics (INAGEMP), Porto Alegre, Brazil.
     To describe the prevalence and clinical spectrum of microcephaly in South America for the period 2005-14, before the start of the Zika epidemic in 2015, as a baseline for future surveillance as the Zika epidemic spreads and as other infectious causes may emerge in future. Prevalence and case-control study. ECLAMC (Latin American Collaborative Study of Congenital Malformations) database derived from 107 hospitals in 10 South American countries, 2005 to 2014. Read More

    Syphilis and HIV infections among pregnant women attending antenatal clinics in Republic of Congo.
    Pan Afr Med J 2017 7;28. Epub 2017 Sep 7.
    Laboratoire National de Santé Publique, 120 avenue du Général Charles de Gaule, BP: 120 Brazzaville, Congo.
    Introduction: HIV and syphilis during pregnancy remain a public health concern especially in developing countries. Pregnant women attending antenatal clinics sites for the first time between September and December 2011 and who accepted to participate in the study were enrolled. The objective was to estimate the syphilis and HIV infection rate in this population. Read More

    Comparison of seropositivity of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis among Hospital Cornea Retrieval Programme-Donors versus voluntary cornea donors at a large eye bank in Eastern India.
    Indian J Ophthalmol 2017 Nov;65(11):1138-1142
    Department of Cornea and Eye Bank Services, Disha Eye Hospitals, Kolkata, West Bengal, India.
    Purpose: To compare the serology profile of donors from Hospital Cornea Retrieval Programme-donors (HCRP-D) and voluntary cornea donors (VC-D) from a large eye bank in Eastern India.

    Methods: This is a retrospective analysis of donor details from January 2011 to December 2016. Donor demographics, cause of death, and serology reports were compiled. Read More

    Secondary syphilis presenting as leucoderma syphiliticum: case report and review.
    Rev Inst Med Trop Sao Paulo 2017 Nov 6;59:e74. Epub 2017 Nov 6.
    Universidade Federal do Estado do Rio de Janeiro, Hospital Universitário Gaffrée e Guinle, Centro de Ciências Biológicas e da Saúde, Rio de Janeiro, Rio de Janeiro, Brazil.
    Leucoderma syphiliticum (LS), originally described as syphilide pigmentaire, encompasses a spectrum of dyschromic lesions that emerge during the course of secondary syphilis. Very few case reports are available in modern biomedical databases. We present the case of a 57-year-old HIV-infected male patient who presented with several round to oval, non-scaling, slightly raised and well-demarcated hypochromic lesions scattered over the trunk, abdomen, dorsum, and arms. Read More

    Chemical composition and insecticidal activity of the essential oil from Helichrysum faradifani endemic to Madagascar.
    Nat Prod Res 2017 Nov 3:1-9. Epub 2017 Nov 3.
    f School of Pharmacy , University of Camerino , Camerino , Italy.
    Helichrysum faradifani (Asteraceae) is a perennial shrub growing in rocky and sandy places of Madagascar. The plant is used in the Malagasy traditional medicine as a wound-healing agent, disinfectant and for the treatment of syphilis, diarrhea, cough and headache. In the present work, we analysed the chemical composition of the essential oil distilled from the aerial parts of H. Read More

    The cost and cost-effectiveness of rapid testing strategies for yaws diagnosis and surveillance.
    PLoS Negl Trop Dis 2017 Oct 26;11(10):e0005985. Epub 2017 Oct 26.
    Unit of General Epidemiology and Disease Control, Institute of Tropical Medicine, Antwerp, Belgium.
    Background: Yaws is a non-venereal treponemal infection caused by Treponema pallidum subspecies pertenue. The disease is targeted by WHO for eradication by 2020. Rapid diagnostic tests (RDTs) are envisaged for confirmation of clinical cases during treatment campaigns and for certification of the interruption of transmission. Read More

    Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: A retrospective case study.
    Medicine (Baltimore) 2017 Oct;96(43):e8376
    aDepartment of Ophthalmology, The Affiliated Guangren Hospital of Xi'an Jiaotong University College of Medicine bDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
    Syphilitic chorioretinitis should be included in differential diagnosis of any form of ocular inflammation. A significantly higher proportion of human immunodeficiency virus (HIV)-positive patients with ocular syphilis as compared to HIV-negative cases have been reported in published studies. However, the clinical signs and symptoms are more insidious in HIV-negative patients who are easily misdiagnosed. Read More

    [Co-infections of HIV, syphilis and HSV-2 among men who have sex with men at the voluntary HIV counseling and testing clinics in Shanghai].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 Oct;38(10):1363-1366
    Putuo District Center for Disease Control and Prevention, Shanghai 200333, China.
    To understand the prevalence rates of HIV-syphilis and HIV-herpes simplex virus 2 (HSV-2) co-infections and related factors among men having sex with men (MSM) who had visited the voluntary HIV counseling and testing (VCT) clinics in Shanghai, China.756 eligible MSM who attended the VCT clinics of Shanghai Municipality and Putuo district during March to August, 2015 were recruited to participate in a cross-sectional survey with questionnaire interview and blood testing for HIV, syphilis and HSV-2.A total of 732 participants completed a valid questionnaire survey. Read More

    Screening for HIV, hepatitis B and syphilis on dried blood spots: A promising method to better reach hidden high-risk populations with self-collected sampling.
    PLoS One 2017 20;12(10):e0186722. Epub 2017 Oct 20.
    Department of Medical Microbiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
    Introduction: Many people at high risk for sexually transmitted infections (STIs), e.g., men who have sex with men (MSM), are not optimally reached by current sexual health care systems with testing. Read More

    Strong associations between national prevalence of various STIs suggests sexual network connectivity is a common underpinning risk factor.
    BMC Infect Dis 2017 10 12;17(1):682. Epub 2017 Oct 12.
    Sexually Transmitted Infections HIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium.
    Background: If national peak Human Immunodeficiency Virus (HIV) prevalence is positively associated with the prevalence of other sexually transmitted infections (STIs) from before or early on in the HIV epidemics this would suggest common underlying drivers.

    Methods: Pearson's correlations were calculated between the prevalence of seven STIs at a country-level: chlamydia, gonorrhoea, trichomoniasis, syphilis, bacterial vaginosis, herpes simplex virus-2 (HSV-2) and HIV.

    Results: The prevalence of all the STIs was highest in the sub-Saharan African region excluding chlamydia. Read More

    Development and Evaluation of a Loop-Mediated Isothermal Amplification Assay for the Detection ofDNA in the Peripheral Blood of Secondary Syphilis Patients.
    Am J Trop Med Hyg 2017 Dec 28;97(6):1673-1678. Epub 2017 Sep 28.
    Hunan Provincial Key Laboratory for Special Pathogen Prevention and Control, Hengyang, China.
    Secondary syphilis (SS) has always been puzzling for the clinicians because of the similarity of the appearance of skin rashes with other dermatoses. Serological assays are useful, but less sensitive at an early stage of SS or when patients are immunodeficient. Therefore, there is an urgent need to develop a rapid and effective tool for the diagnosis of SS, which may play an important role in the control of epidemic syphilis outbreaks. Read More

    Sclerokeratouveitis and lens dislocation in a patient with genital ulcer: was the great imitator imitated?
    BMJ Case Rep 2017 Oct 4;2017. Epub 2017 Oct 4.
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
    Uveitis is the most common ocular manifestation of syphilis, while scleritis is rare. A case of nodular scleritis, peripheral keratitis and uveitis in a patient with genital ulcer is presented in this report. This patient had a clinical profile suggestive of syphilis, though the serology was negative for treponemal antibodies. Read More

    A Smartphone Application to Reduce Time-to-Notification of Sexually Transmitted Infections.
    Am J Public Health 2017 Nov 21;107(11):1795-1800. Epub 2017 Sep 21.
    Adam Carl Cohen is with the Public Health Division, AIDS Healthcare Foundation, Los Angeles, CA. Frederick Zimmerman is with the Department of Health Policy and Management, University of California, Los Angeles (UCLA) Fielding School of Public Health. Michael Prelip and Deborah Glik are with the Department of Community Health Sciences, UCLA Fielding School of Public Health.
    Objectives: To measure whether the implementation of Healthvana-an online patient engagement platform and smartphone application-reduced the number of days between sexually transmitted infection (STI) testing, notification, and treatment at AIDS Healthcare Foundation (AHF) Wellness Centers.

    Methods: We analyzed the retrospective data for 917 male clients who tested positive and received treatment for chlamydia, gonorrhea, or syphilis between January 1, 2014, and December 31, 2015. We included 8 AHF Wellness Centers from California and Florida in the study. Read More

    Aberrant Humoral Immune Responses in Neurosyphilis: CXCL13/CXCR5 Play a Pivotal Role for B-Cell Recruitment to the Cerebrospinal Fluid.
    J Infect Dis 2017 Sep;216(5):534-544
    Shanghai Skin Disease Hospital, Clinical School of Anhui Medical University.
    Background: Previous studies documented that humoral immune responses participated in neurological damage in neurosyphilis patients. However, the mechanisms that trigger and maintain humoral immunity involved in neurosyphilis remain unknown.

    Methods: Using flow cytometry, expression of B cells was measured in neurosyphilis and non-neurosyphilis. Read More

    Spectrum of infectious diseases among newly arrived Eritrean refugees in Switzerland: a cross-sectional study.
    Int J Public Health 2017 Sep 19. Epub 2017 Sep 19.
    Swiss Tropical and Public Health Institute, CH-4002, Basel, Switzerland.
    Objectives: Our study aimed at determining the prevalence of selected infectious diseases among recently arrived Eritrean refugees in Switzerland.

    Methods: In this cross-sectional study, asymptomatic Eritrean migrants aged ≥16 years who arrived <24 months ago were recruited at refugee centres in Switzerland. Infectious disease screening included serology for HIV, hepatitis B and C, syphilis and schistosomiasis, polymerase chain reaction (PCR) for malaria, stool microscopy for helminths and intestinal protozoa and circulating cathodic antigen (CCA) testing in urine for schistosomiasis. Read More

    Effects on preventing mother-to-child transmission of syphilis and associated adverse pregnant outcomes: a longitudinal study from 2001 to 2015 in Shanghai, China.
    BMC Infect Dis 2017 09 18;17(1):626. Epub 2017 Sep 18.
    Department of Epidemiology, School of Public Health Fudan University, Shanghai, China.
    Background: Maternal syphilis is a health threat to both the pregnant women and the children. This study aimed to delineate the longitudinal trend of maternal syphilis and burden of associated adverse pregnant outcomes (APOs) in Shanghai from 2001 to 2015; and to evaluate the effects of preventing mother-to-child transmission (PMTCT) of syphilis in Shanghai with regard to service coverage and APOs averted.

    Methods: PMTCT program of syphilis has been implemented since 2001. Read More

    Factors associated with syphilis treatment failure and reinfection: a longitudinal cohort study in Shenzhen, China.
    BMC Infect Dis 2017 09 13;17(1):620. Epub 2017 Sep 13.
    Department of Dermatology and Venereology, Nanshan Center for Chronic Disease Control, Shenzhen, 518054, China.
    Background: The treatment failure and reinfection rates among syphilis patients are high, and relevant studies in China are limited. The aim of this study was to detect the rates of treatment failure and reinfection after syphilis treatment and to explore the potential associated factors.

    Methods: We conducted a longitudinal cohort study in a sexually transmitted disease clinic, the Department of Dermatology and Venereology in Nanshan Center for Chronic Disease Control. Read More

    Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Ghana, Africa: Identical genome sequences in samples isolated more than 7 years apart.
    PLoS Negl Trop Dis 2017 Sep 8;11(9):e0005894. Epub 2017 Sep 8.
    Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno, Czech Republic.
    Background: Treponema pallidum subsp. pertenue (TPE) is the causative agent of yaws, a multi-stage disease, endemic in tropical regions of Africa, Asia, Oceania, and South America. To date, four TPE strains have been completely sequenced including three TPE strains of human origin (Samoa D, CDC-2, and Gauthier) and one TPE strain (Fribourg-Blanc) isolated from a baboon. Read More

    Secondary syphilis: The great imitator can't be forgotten.
    Rev Assoc Med Bras (1992) 2017 Jun;63(6):481-483
    MD, General Practitioner, Porto Alegre, RS, Brazil.
    Syphilis is an infection caused by Treponema pallidum, mainly transmitted by sexual contact. Since 2001, primary and secondary syphilis rates started to rise, with an epidemic resurgence. The authors describe an exuberant case of secondary syphilis, presenting with annular and lichen planus-like lesions, as well as one mucocutaneous lesion. Read More

    Provider Adherence to Syphilis Testing Recommendations for Women Delivering a Stillbirth.
    Sex Transm Dis 2017 Nov;44(11):685-690
    From the *Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA, and †Oak Ridge Institute of Science and Education, Oak Ridge, TN.
    Objective: To assess overall adherence to Centers for Disease Control and Prevention and American College of Obstetrics and Gynecology recommended guidelines for syphilis testing among women who delivered a stillbirth and compare it with other tests recommended for stillbirth evaluation.

    Methods: We used MarketScan claims data with 40 million commercially insured and 8 million Medicaid enrollees annually to estimate prenatal care and follow-up testing among women who had stillbirths between January 1, 2013, and December 24, 2013. Stillbirth was identified if women had any International Classification of Disease, Ninth Revision codes related to a stillbirth outcome. Read More

    The Annual Economic Burden of Syphilis: An Estimation of Direct, Productivity, and Intangible Costs for Syphilis in Guangdong Initiative for Comprehensive Control of Syphilis Sites.
    Sex Transm Dis 2017 Nov;44(11):671-677
    From the *Department of Public Health, Wuxi Center for Disease Control and Prevention, Wuxi, China; †Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China; and ‡Department of Sexually Transmitted Infections Control, Dermatology Hospital of Southern Medical University, Guangzhou, China.
    Background: Syphilis has continuously posed a great challenge to China. However, very little data existed regarding the cost of syphilis. Taking Guangdong Initiative for Comprehensive Control of Syphilis area as the research site, we aimed to comprehensively measure the annual economic burden of syphilis from a societal perspective. Read More

    Comparison of Doxycycline and Benzathine Penicillin G for the Treatment of Early Syphilis.
    Acta Dermatovenerol Croat 2017 Jul;25(2):107-111
    Prof. Hongqing Tian, Prof. Furen Zhang, Shandong Provincial Institute of Dermatology and Venereology, 27397 Jingshi Road, Jinan, Shandong Province, 250022 China,
    Doxycycline is the preferred recommended second-line treatment for the treatment of early syphilis. Recent reports showed a declining efficacy trend of doxycycline in treatment of early syphilis. The aim of our study was to assess the serological response to the treatment for early syphilis with doxycycline compared with benzathine penicillin G and evaluate whether doxycycline is still an effective agent for the treatment of early syphilis. Read More

    Neurosyphilis in Africa: A systematic review.
    PLoS Negl Trop Dis 2017 Aug 31;11(8):e0005880. Epub 2017 Aug 31.
    Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
    Introduction: Neurological involvement is one of the most important clinical manifestations of syphilis and neurological disease occurs in both early and late syphilis. The impact of HIV co-infection on clinical neurosyphilis remains unclear. The highest prevalence of both syphilis and HIV is in Africa. Read More

    The current status of syphilis prevention and control in Jiangsu province, China: A cross-sectional study.
    PLoS One 2017 24;12(8):e0183409. Epub 2017 Aug 24.
    Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
    Objective: To analyze the midterm evaluation data from the National Syphilis Prevention and Control Plan (2010-2020) and evaluate the current status of syphilis prevention and control in Jiangsu province, China.

    Methods: We collected data via (1) field surveys conducted in 2015 and (2) data recorded in existing syphilis surveillance systems. We conducted descriptive statistical analysis to evaluate the current landscape of syphilis control initiatives and their potential effect in syphilis control. Read More

    The prevalence and incidence of active syphilis in women in Morocco, 1995-2016: Model-based estimation and implications for STI surveillance.
    PLoS One 2017 24;12(8):e0181498. Epub 2017 Aug 24.
    Avenir Health, Glastonbury, Connecticut, United States of America.
    Background: Evolving health priorities and resource constraints mean that countries require data on trends in sexually transmitted infections (STI) burden, to inform program planning and resource allocation. We applied the Spectrum STI estimation tool to estimate the prevalence and incidence of active syphilis in adult women in Morocco over 1995 to 2016. The results from the analysis are being used to inform Morocco's national HIV/STI strategy, target setting and program evaluation. Read More

    Risk factors for syphilis in women: case-control study.
    Rev Saude Publica 2017 Aug 17;51:78. Epub 2017 Aug 17.
    Departamento de Medicina Tropical. Universidade Federal de Pernambuco. Recife, PE, Brasil.
    Objective: To determine the sociodemographic, behavioral, and health care factors related to the occurrence of syphilis in women treated at public maternity hospitals.

    Methods: This is a case-control study (239 cases and 322 controls) with women admitted to seven maternity hospitals in the municipality of Recife, Brazil, from July 2013 to July 2014. Eligible women were recruited after the result of the VDRL (Venereal Disease Research Laboratory) under any titration. Read More

    High Prevalence ofInfection in Brazilian Prisoners.
    Am J Trop Med Hyg 2017 Oct 18;97(4):1078-1084. Epub 2017 Aug 18.
    Laboratório de Pesquisa em Ciências da Saúde, Universidade Federal da Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, Brazil.
    The number of new syphilis cases in Brazil has risen alarmingly in recent years. However, there is limited data regarding syphilis prevalence in the Brazilian prison population. To facilitate the development of effective interventions, a cross-sectional study was undertaken to determine the prevalence ofinfection, active syphilis, and associated risk factors among Brazilian prisoners. Read More

    New Surge of Syphilis among Patients Living with Human Immunodeficiency Virus in Martinique in 2015.
    Am J Trop Med Hyg 2017 Sep 18;97(3):923-926. Epub 2017 Aug 18.
    INSERM CIC1425, Centre Hospitalier Universitaire de Martinique, Fort de France, France.
    A syphilis outbreak began in Martinique, French Antilles, in 2004, initially among men who had sex with men (MSM) and who were living with human immunodeficiency virus (HIV). The outbreak subsequently affected all groups at risk, leading to a first epidemic peak in 2008. After an initial decrease, the outbreak started growing again in 2014 among patients living with HIV with unprecedented incidence among MSM. Read More

    Erythema multiforme triggered by Treponema pallidum infection in an HIV-infected patient.
    Int J STD AIDS 2018 Jan 18;29(1):99-102. Epub 2017 Aug 18.
    1 Emilio Ribas Infectious Diseases Institute (IIER), São Paulo, Brazil.
    We are currently facing a worldwide epidemic of syphilis. Clinical manifestations that are rarely seen have been encountered, leading the dermatologist to confront unusual clinical conditions in daily practice. Erythema multiforme triggered by syphilis is very rare and is also seldom reported in the literature. Read More

    Cost Analysis and Performance Assessment of Partner Services for Human Immunodeficiency Virus and Sexually Transmitted Diseases, New York State, 2014.
    Health Serv Res 2017 Dec 11;52 Suppl 2:2331-2342. Epub 2017 Aug 11.
    Rockefeller Institute of Government, Albany, NY.
    Objective: To estimate the programmatic costs of partner services for HIV, syphilis, gonorrhea, and chlamydial infection.

    Study Setting: New York State and local health departments conducting partner services activities in 2014.

    Study Design: A cost analysis estimated, from the state perspective, total program costs and cost per case assignment, patient interview, partner notification, and disease-specific key performance indicator. Read More

    Prognostic Factors in Syphilitic Uveitis.
    Ophthalmology 2017 Dec 2;124(12):1808-1816. Epub 2017 Aug 2.
    Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France; Present address: Department of Internal Medicine, Hôpital St. Louis, Paris, France. Electronic address:
    Purpose: To identify predictors of treatment success in syphilitic uveitis (SU).

    Design: Retrospective multicentric analysis of patients treated for SU.

    Participants: A total of 95 eyes (66 patients, mean [standard deviation] aged 49 [12. Read More

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