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Neuroimaging-evident lesional pathology associated with REM sleep behavior disorder.

Sleep Med 2015 Dec 14;16(12):1502-10. Epub 2015 Sep 14.

Mayo Center for Sleep Medicine, Mayo Clinic and Foundation, Rochester, MN, USA; Department of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA; Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA. Electronic address:

Background/rationale: Rapid eye movement (REM) sleep behavior disorder (RBD) is a potentially injurious parasomnia characterized by dream enactment behavior and polysomnographic REM sleep without atonia (RSWA). Recently, RBD not only has been shown to be strongly associated with synucleinopathy neurodegeneration but has also been rarely reported to be associated with structural lesions involving the brainstem or limbic system. The aim of this study was to describe the clinical, neuroimaging, and outcome characteristics in a case series of patients with lesional RBD. Read More

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http://dx.doi.org/10.1016/j.sleep.2015.07.018DOI Listing
December 2015
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