6,530 results match your criteria Encephalitis Japanese


Differential replication efficiencies between Japanese encephalitis virus genotype I and III in avian cultured cells and young domestic ducklings.

PLoS Negl Trop Dis 2018 Dec 18;12(12):e0007046. Epub 2018 Dec 18.

Department of Swine Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, PR China.

Japanese encephalitis virus (JEV) genotype dominance has shifted to genotype I (GI) from genotype III (GIII) in China as demonstrated by molecular epidemiological surveillance. In this study, we performed a serological survey in JEV-non-vaccinated pigs to confirm JEV genotype shift at the sero-epidemiological level. The average ratio of GI/GIII infection was 1. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007046DOI Listing
December 2018

Japanese Encephalitis Virus-induced let-7a/b interacted with the NOTCH-TLR7 pathway in microglia and facilitated neuronal death via caspase activation.

J Neurochem 2018 Dec 17. Epub 2018 Dec 17.

Translational Health Science and Technology Institute, Faridabad, India.

MicroRNAs (miRNAs) released from the activated microglia upon neurotropic virus infection may exacerbate the neuronal damage. Here, we identified let-7a and let-7b (let-7a/b) as one of the essential miRNAs overexpressed upon Japanese Encephalitis virus (JEV) infection and released in the culture supernatant of the JEV-infected microglial cells through extracellular vesicles. The let-7a/b were previously reported to modulate inflammation in microglial cells through Toll-like receptor 7 (TLR7) pathways; though their role in accelerating JEV pathogenesis remain unexplored. Read More

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http://dx.doi.org/10.1111/jnc.14645DOI Listing
December 2018

The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions.

Authors:
Po-Yuan Ke

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Department of Biochemistry & Molecular Biology and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.

Autophagy is an evolutionarily conserved cellular process in which intracellular components are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and metabolic homeostasis. Flavivirus infections underlie multiple human diseases and thus exert an immense burden on public health worldwide. Mounting evidence indicates that host autophagy is subverted to modulate the life cycles of flaviviruses, such as hepatitis C virus, dengue virus, Japanese encephalitis virus, West Nile virus and Zika virus. Read More

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http://dx.doi.org/10.3390/ijms19123940DOI Listing
December 2018
1 Read

Japanese Encephalitis Virus NS1' Protein Antagonizes Interferon Beta Production.

Virol Sin 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.

Japanese encephalitis virus (JEV) is a mosquito-borne virus and the major cause of viral encephalitis in Asia. NS1', a 52-amino acid C-terminal extension of NS1, is generated with a -1 programmed ribosomal frameshift and is only present in members of the Japanese encephalitis serogroup of flaviviruses. Previous studies demonstrated that NS1' plays a vital role in virulence, but the mechanism is unclear. Read More

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http://dx.doi.org/10.1007/s12250-018-0067-5DOI Listing
December 2018
2 Reads

Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses.

EBioMedicine 2018 Dec 5. Epub 2018 Dec 5.

Disease Biology Laboratory, Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, India. Electronic address:

Background: Activated platelets release cytokines/proteins including CXCL4 (PF4), CCL5 and fibrinopeptides, which regulate infection of several pathogenic viruses such as HIV, H1N1 and HCV in human. Since platelet activation is the hallmark of Dengue virus (DV) infection, we investigated the role of platelets in DV replication and also in a closely related Japanese Encephalitis virus (JEV).

Methods And Findings: Microscopy and PCR analysis revealed a 4-fold increase in DV replication in primary monocytes or monocytic THP-1 cells in vitro upon incubation with either DV-activated platelets or supernatant from DV-activated platelets. Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.11.049DOI Listing
December 2018

Isolation and Genome Phylogenetic Analysis of Arthropod-Borne Viruses, Including Akabane Virus, from Mosquitoes Collected in Hunan Province, China.

Vector Borne Zoonotic Dis 2018 Dec 11. Epub 2018 Dec 11.

1 State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention , Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China .

This study investigated the abundance of mosquitoes and circulation of mosquito-borne arboviruses from 16 villages in 8 cities of Hunan Province, China, in July-August of 2010 and in August of 2011. In total, 16,076 mosquitoes consisting of seven species from four genera were collected by ultraviolet-light trap. Culex quinquefasciatus was the most common species, accounting for 50. Read More

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https://www.liebertpub.com/doi/10.1089/vbz.2018.2267
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http://dx.doi.org/10.1089/vbz.2018.2267DOI Listing
December 2018
2 Reads

West Nile virus in Algeria: a comprehensive overview.

New Microbes New Infect 2019 Jan 21;27:9-13. Epub 2018 Oct 21.

UMR VITROME, Aix-Marseille Université, IRD, Service de Santé des Armées, Assistance Publique-Hôpitaux de Marseille, IHU Méditerranée-Infection, Marseille, France.

West Nile virus (WNV) is a mosquito-borne virus belonging to the genus related to the Japanese encephalitis antigenic complex of family. It is transmitted by the bite of infected mosquitoes. The virus is maintained in a mosquito-bird-mosquito transmission cycle. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20522975183009
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http://dx.doi.org/10.1016/j.nmni.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260397PMC
January 2019
3 Reads

A cross-sectional study to assess the awareness and practices related to adult immunization among nursing students in a metropolitan city.

J Educ Health Promot 2018 29;7:129. Epub 2018 Oct 29.

Department of Community Medicine, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Introduction: Immunization against vaccine-preventable diseases in adults is the need of the hour. The student nurses by virtue of training are the frontline health workers dealing with patient care. They are exposed to maximum risk of contracting the diseases. Read More

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http://www.jehp.net/text.asp?2018/7/1/129/244389
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http://dx.doi.org/10.4103/jehp.jehp_55_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225393PMC
October 2018
4 Reads

Antigenic relationship among zoonotic flaviviruses from Italy.

Infect Genet Evol 2018 Dec 2;68:91-97. Epub 2018 Dec 2.

School of Veterinary Medicine, University of Surrey, Guildford, UK.

Here we report studies of the antigenic relationship of West Nile virus (WNV) and Usutu virus (USUV), two zoonotic flaviviruses from Italy, together with a Japanese encephalitis virus (JEV) strain and compared them with their genetic relationship using the immunodominant viral E protein. Thirty-nine isolates and reference strains were inactivated and used to immunize rabbits to produce hyper immune sera. Serum samples were tested by neutralization against all isolates and results visualized by generating antigenic map. Read More

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http://dx.doi.org/10.1016/j.meegid.2018.11.023DOI Listing
December 2018
2 Reads

Vaccine-preventable disease control in the People's Republic of China: 1949-2016.

Vaccine 2018 Dec 26;36(52):8131-8137. Epub 2018 Nov 26.

National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China. Electronic address:

Background: China's immunization program is one of the oldest and largest in the world. Rates of vaccine-preventable diseases (VPD) are comparable to those in high-income countries. The program's evolution has been characterized by ambitious target setting and innovative strategies that have not been widely described. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.10.005DOI Listing
December 2018
2 Reads

Membrane trafficking RNA interference screen identifies a crucial role of the clathrin endocytic pathway and ARP2/3 complex for Japanese encephalitis virus infection in HeLa cells.

J Gen Virol 2018 Nov 29. Epub 2018 Nov 29.

3​Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India.

Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is one of the leading global causes of virus-induced encephalitis. The infectious life-cycle of viruses is heavily dependent on the host membrane trafficking network. Here, we have performed a RNA-interference-based screen using a siRNA panel targeting 136 membrane trafficking proteins to identify the key regulators of JEV infection in HeLa cells. Read More

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http://dx.doi.org/10.1099/jgv.0.001182DOI Listing
November 2018
1 Read

[A 64-year-old male with recurrence of herpes simplex encephalitis after suffering from severe pneumonia and sepsis].

Rinsho Shinkeigaku 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurology, NTT Medical Center Tokyo.

The case is a 64-year-old male who had a past history of herpes simplex virus encephalitis (HSE) two years prior to his admission. He was admitted to our hospital due to severe pneumonia and sepsis. Several days later, he developed HSE again. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001226DOI Listing
November 2018
1 Read

[Cerebral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein (MOG) antibody].

Rinsho Shinkeigaku 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurology, Hyogo Prefectural Amagasaki General Medical Center.

A 27-year-old man developed acute encephalitis with headache, fever, seizures, and aphasia. Analysis of cerebrospinal fluid showed elevated levels of cell counts and protein. A brain MRI demonstrated increased FLAIR signals in the left cerebral cortex with cortical swelling. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001224DOI Listing
November 2018
1 Read

Disseminated toxoplasmosis with atypical symptoms which developed with exacerbation of systemic lupus erythematosus.

Lupus 2018 Nov 28:961203318815583. Epub 2018 Nov 28.

1 Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan.

Toxoplasma is a common parasite worldwide that mainly affects the brain, lungs and eyes. Although toxoplasmic encephalitis is a lethal disease without treatment, past case reports show most patients with systemic lupus erythematosus who developed toxoplasmic encephalitis were misdiagnosed and treated as neuropsychiatric systemic lupus erythematosus, which led to unfavorable outcomes. We herein describe a case of disseminated toxoplasmosis affecting all the above organs with atypical symptoms, which developed with exacerbation of systemic lupus erythematosus. Read More

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http://dx.doi.org/10.1177/0961203318815583DOI Listing
November 2018
1 Read

Experimental transmission of Zika virus by Aedes japonicus japonicus from southwestern Germany.

Emerg Microbes Infect 2018 Nov 28;7(1):192. Epub 2018 Nov 28.

Bernhard Nocht Institute for Tropical Medicine, 20359, Hamburg, Germany.

The invasive mosquito species Aedes japonicus japonicus (Ae. japonicus) is widely distributed in Central Europe and is a known vector of various arboviruses in the laboratory, including flaviviruses such as Japanese Encephalitis virus or West Nile virus. However, the vector competence of Ae. Read More

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http://dx.doi.org/10.1038/s41426-018-0195-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258727PMC
November 2018
1 Read

Neuronal transcriptomic responses to Japanese encephalitis virus infection with a special focus on chemokine CXCL11 and pattern recognition receptors RIG-1 and MDA5.

Virology 2018 Nov 24;527:107-115. Epub 2018 Nov 24.

Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

Japanese encephalitis virus (JEV) causes central nervous system neuronal injury and inflammation. A clear understanding of neuronal responses to JEV infection remains elusive. Using the Affymetrix array to investigate the transcriptome of infected SK-N-MC cells, 1316 and 2737 dysregulated genes (≥ 2/-2 fold change, P < 0. Read More

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http://dx.doi.org/10.1016/j.virol.2018.10.015DOI Listing
November 2018
2 Reads

Detection of anti-viral antibodies from meat juice of wild boars.

J Vet Med Sci 2018 Nov 23. Epub 2018 Nov 23.

Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University.

Wild boars are a reservoir for many zoonotic pathogens and a good sentinel for surveillance of zoonotic viral infections, but collection of serum samples from wild boars in the field is sometimes difficult and requires special equipment and techniques. In this study, ELISA using meat juices extracted from the heart and diaphragm of wild boars, instead of serum samples, was performed to detect antibodies against zoonotic pathogens, Japanese encephalitis virus and hepatitis E virus. The results of ELISA using meat juice samples were significantly correlated with those using serum samples and meat juice contained one-fifth the antibodies of serum samples. Read More

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http://dx.doi.org/10.1292/jvms.18-0576DOI Listing
November 2018
1 Read

Possible pathogenicity of Japanese encephalitis virus in newly hatched domestic ducklings.

Vet Microbiol 2018 Dec 22;227:8-11. Epub 2018 Oct 22.

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, No. 518, Ziyue Road, Shanghai, 200241, PR China. Electronic address:

Japanese encephalitis virus (JEV) is a zoonotic flavivirus that is transmitted by mosquitoes and vertebrate-amplifying hosts, including birds. Domestic ducks are susceptible to JEV infection and develop various levels of viremia. We tested the pathogenicities of seven JEV strains in newly hatched domestic ducklings. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.10.016DOI Listing
December 2018
1 Read

Diagnosis of viral central nervous system infections using antipeptide antibody against viral antigen by ELISA.

Acta Virol 2018 ;62(4):386-393

Viral infections of the central nervous system (CNS) occur sporadically and have been extensively studied because of the potential for permanent neurological damage or death. The neurotropic viruses have been reported to lead to various CNS infections. The objective of the present study is to develop an antigen detection ELISA protocol for detection and quantification of viral antigen in CNS infections by assessing the usefulness of antipeptide antibodies against potential peptides of cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella zoster virus (VZV), Japanese encephalitis virus (JEV), dengue (DENV), West Nile virus (WNV) and Chandipura virus (CHPV). Read More

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http://dx.doi.org/10.4149/av_2018_406DOI Listing
January 2018
1 Read

Acute necrotizing encephalopathy and a carnitine palmitoyltransferase 2 variant in an adult.

J Clin Neurosci 2018 Nov 20. Epub 2018 Nov 20.

Department of Neurology, Nagano Red Cross Hospital, 5-22-1, Wakasato, Nagano 380-8582, Japan.

A 54-year-old Japanese man had a fever of over 40 °C for 7 days and developed unconsciousness, seizure and respiratory arrest. T2-weighted imaging magnetic resonance imaging revealed high-intensity signals on bilateral thalamus and it gradually extended to the brain white matter. Moreover, the lesion progressed to the spinal gray matter. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.045DOI Listing
November 2018
1 Read

Evaluation of cholinergic functions in patients with Japanese encephalitis and Herpes simplex encephalitis.

Brain Res 2018 Nov 20. Epub 2018 Nov 20.

Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Cognitive and memory impairment are related to cholinergic dysfunction and are important complication of viral encephalitis, In view of paucity of studies on cholinergic dysfunction in encephalitis, this study has been undertaken. We report AChE and M2 receptor levels in HSE and Japanese encephalitis (JE) patients, and correlate these with cognitive functions and MRI findings. Patients with JE and HSE were evaluated for consciousness, neurological and MRI findings , plasma AChE and M2 receptor levels on admission and after one year Results: Twenty-nine patients with JE and 23 with HSE were included . Read More

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http://dx.doi.org/10.1016/j.brainres.2018.11.028DOI Listing
November 2018
1 Read

Crustin-capped selenium nanowires against microbial pathogens and Japanese encephalitis mosquito vectors - Insights on their toxicity and internalization.

J Trace Elem Med Biol 2019 Jan 18;51:191-203. Epub 2018 Oct 18.

Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.

Herein, we reported a method to synthesize selenium nanowires (Cr-SeNWs) relying to purified cysteine-rich antimicrobial peptide crustin in presence of ascorbic acid. Cr-SeNWs were characterized by UV-vis, XRD, FTIR and Raman spectroscopy, as well as SEM, HR-TEM and EDAX. The UV-vis spectroscopy peak was noted at 350 nm. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.10.017DOI Listing
January 2019
4 Reads
2.490 Impact Factor

Analysis of Zika virus neutralizing antibodies in normal healthy Thais.

Sci Rep 2018 Nov 21;8(1):17193. Epub 2018 Nov 21.

Institute of Molecular Biosciences, Mahidol University, Bangkok, Thailand.

Zika virus (ZIKV) infections have been reported from all over Thailand, but the number of reported cases remains low, suggesting a degree of immune protection against ZIKV infection. To address this possibility, the presence of ZIKV neutralizing antibodies was determined in serum from 135 healthy Thai adults with a plaque reduction neutralization test (PRNT), and a number of samples were subsequently analyzed for the presence of neutralizing antibodies to dengue virus (DENV) and Japanese encephalitis virus (JEV). Results showed that 70. Read More

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http://dx.doi.org/10.1038/s41598-018-35643-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249253PMC
November 2018
4 Reads

RNA helicase A is an important host factor involved in dengue virus replication.

J Virol 2018 Nov 21. Epub 2018 Nov 21.

Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China

Dengue virus (DENV) utilizes host factors throughout its life cycle. In this study, we identified RNA helicase A (RHA), a member of the DEAD/H helicase family, as an important host factor of DENV. In response to DENV2 infection, nuclear RHA protein was partially redistributed into the cytoplasm. Read More

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http://dx.doi.org/10.1128/JVI.01306-18DOI Listing
November 2018
1 Read

Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis.

Emerg Microbes Infect 2018 Nov 21;7(1):187. Epub 2018 Nov 21.

Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.

The genus Flavivirus contains many important pathogens, including dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV). AR-12 is a celecoxib-derived anticancer agent that possesses antiviral activity against a broad range of viruses. We pharmacologically exploited this unique activity to develop additional antiviral agents, resulting in the production of the AR-12 derivatives P12-23 and P12-34. Read More

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http://dx.doi.org/10.1038/s41426-018-0191-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246607PMC
November 2018
2 Reads

Artificial MicroRNA-Mediated Inhibition of Japanese Encephalitis Virus Replication in Neuronal Cells.

Nucleic Acid Ther 2018 Dec 20;28(6):357-365. Epub 2018 Nov 20.

1 Vaccine and Infectious Disease Research Center (VIDRC), Translational Health Science and Technology Institute (THSTI), Faridabad, India.

Artificial microRNA (amiRNA)-mediated inhibition of viral replication has recently gained importance as a strategy for antiviral therapy. In this study, we evaluated the benefit of using the amiRNA vector against Japanese encephalitis virus (JEV). We designed three single amiRNA sequences against the consensus sequence of 3' untranslated region (3'UTR) of JEV and tested their efficacy against cell culture-grown JEV Vellore strain (P20778) in neuronal cells. Read More

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https://www.liebertpub.com/doi/10.1089/nat.2018.0743
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http://dx.doi.org/10.1089/nat.2018.0743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277082PMC
December 2018
2 Reads

Teaching NeuroImages: Japanese encephalitis.

Neurology 2018 Nov;91(21):e2031-e2032

From the Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

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http://dx.doi.org/10.1212/WNL.0000000000006553DOI Listing
November 2018
1 Read

[Mosquitoes, midges and related arboviruses in southeast Sichuan province].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Oct;39(10):1381-1386

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

To investigate the distribution patterns of mosquitoes, midges and related arboviruses in Sichuan province. Blood-sucking insects were collected from houses and pens, using the ultraviolet lights. Mosquito samples were classified according to morphologic characteristics and then stored at liquid nitrogen. Read More

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October 2018
1 Read

Detection of central nervous system viral infections in adults in Manado, North Sulawesi, Indonesia.

PLoS One 2018 16;13(11):e0207440. Epub 2018 Nov 16.

Eijkman Institute for Molecular Biology, Jakarta, Indonesia.

Central nervous system (CNS) viral infections are important causes of morbidity and mortality worldwide but the systematic survey of patients admitted to hospitals with CNS infections in many countries, including Indonesia, is limited. To obtain more information regarding the causes of CNS infections in Indonesia, this study was performed to detect and identify viral agents associated with CNS infections amongst in-patients at a referral hospital in Manado, North Sulawesi, Indonesia. Adult patients admitted to R. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207440PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239303PMC
November 2018
5 Reads

TIM-1 Promotes Japanese Encephalitis Virus Entry and Infection.

Viruses 2018 Nov 14;10(11). Epub 2018 Nov 14.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.

Japanese encephalitis virus (JEV) is a mosquito-borne , the leading cause of viral-induced encephalitis. Several host molecules have been identified as the JEV attachment factor; however, the molecules involved in JEV entry remain poorly understood. In the present study, we demonstrate that TIM-1 is important for efficient infection by JEV. Read More

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http://dx.doi.org/10.3390/v10110630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265761PMC
November 2018
1 Read

A Sensitive Nano Luciferase Immune Complex Assay System for Highly Sensitive and Specific Detection of Antibodies Against Tick-Borne Encephalitis Virus.

Vector Borne Zoonotic Dis 2018 Nov 15. Epub 2018 Nov 15.

1 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing, China .

Tick-borne encephalitis virus (TBEV) can cause fever, headache, neurological disorders, and/or peripheral flaccid paralysis; therefore, it is a major threat to public health. A rapid, sensitive, and simple method for detecting anti-TBEV antibodies is needed urgently to determine infection and for vaccine evaluation. Here, a luciferase-based immunocomplex assay system (Luc-IC) was developed to detect TBEV antibodies. Read More

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https://www.liebertpub.com/doi/10.1089/vbz.2018.2330
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http://dx.doi.org/10.1089/vbz.2018.2330DOI Listing
November 2018
5 Reads
2.300 Impact Factor

Evaluation of a new West Nile virus nucleic acid test for screening of blood donations.

Transfusion 2018 Nov 14. Epub 2018 Nov 14.

Medical and Scientific Affairs, Roche Molecular Systems, Inc., Pleasanton, California.

Background: West Nile virus (WNV) is transmitted to humans through mosquito bites and can be further transmitted to humans through transfusion or transplantation. Because most infected individuals are asymptomatic, blood donor screening is important in areas where WNV is endemic. These studies evaluated the performance of a new test for detection of WNV RNA in blood donations. Read More

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http://doi.wiley.com/10.1111/trf.15022
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http://dx.doi.org/10.1111/trf.15022DOI Listing
November 2018
7 Reads
3.230 Impact Factor

Structure analysis and antiviral activity of CW-33 analogues against Japanese encephalitis virus.

Sci Rep 2018 Nov 9;8(1):16595. Epub 2018 Nov 9.

Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan.

Japanese encephalitis virus (JEV) is a member of neurotropic flaviviruses transmitted by mosquito bites, causing severe central nervous system disorders. Current JEV genotype III vaccines have a low protection against genotype I isolates in the risk zone. The lead compound CW-33, ethyl 2-(3',5'-dimethylanilino)-4-oxo-4,5-dihydrofuran-3-carboxylate, demonstrates the antiviral activity against JEV with an IC values of 38. Read More

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http://www.nature.com/articles/s41598-018-34932-4
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http://dx.doi.org/10.1038/s41598-018-34932-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226475PMC
November 2018
5 Reads

High-throughput neutralization assay for multiple flaviviruses based on single-round infectious particles using dengue virus type 1 reporter replicon.

Sci Rep 2018 Nov 9;8(1):16624. Epub 2018 Nov 9.

Department of Virology II, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.

Diseases caused by the genus Flavivirus, including dengue virus (DENV) and Zika virus (ZIKV), have a serious impact on public health worldwide. Due to serological cross-reactivity among flaviviruses, current enzyme-linked immunosorbent assay (ELISA) for IgM/G cannot reliably distinguish between infection by different flaviviruses. In this study, we developed a reporter-based neutralization assay using single-round infectious particles (SRIPs) derived from representative flaviviruses. Read More

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http://dx.doi.org/10.1038/s41598-018-34865-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226426PMC
November 2018
1 Read

Mild encephalitis/encephalopathy with a reversible splenial lesion due to malaria: a case report.

Trop Med Health 2018 6;46:37. Epub 2018 Nov 6.

1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.

Background: Neurological complications from malaria cause significant morbidity and mortality. Severe cerebral malaria occurs as a result of intense sequestration of infected erythrocytes in the cerebral capillaries. However, the pathology of the reversible neurological symptoms remains unclear. Read More

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http://dx.doi.org/10.1186/s41182-018-0119-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219025PMC
November 2018
3 Reads

Metagenomic Sequencing From Mosquitoes in China Reveals a Variety of Insect and Human Viruses.

Front Cell Infect Microbiol 2018 19;8:364. Epub 2018 Oct 19.

Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China.

We collected 8,700 mosquitoes in three sites in China, which belonged to seven species. Their viromes were tested using metagenomic sequencing and bioinformatic analysis. The abundant viral sequences were detected and annotated belonging to more than 50 viral taxonomic families. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202873PMC
October 2018
1 Read

Metagenomic Analysis of in Mosquito Viromes Isolated From Yunnan Province in China Reveals Genes From Dengue and Zika Viruses.

Front Cell Infect Microbiol 2018 24;8:359. Epub 2018 Oct 24.

Yanbian University Medical College, Yanji, China.

More than 6,000 mosquitoes of six species from six sites were collected and tested for their virome using metagenomics sequencing and bioinformatic analysis. The identified viral sequences belonged to more than 50 viral families. The results were verified by PCR of selected viruses in all mosquitoes, followed by phylogenetic analysis. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207848PMC
October 2018
1 Read

A quantitative risk assessment (QRA) of the risk of introduction of the Japanese encephalitis virus (JEV) in the United States via infected mosquitoes transported in aircraft and cargo ships.

Prev Vet Med 2018 Nov 24;160:1-9. Epub 2018 Sep 24.

Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, 66506, United States. Electronic address:

Following a qualitative risk assessment, in which we identified and assessed all viable pathways for the introduction of the Japanese encephalitis virus (JEV) into the United States (US), we identified entry through infected vectors via aircraft and cargo ships as the most likely pathway, and thus considered it further in a quantitative risk assessment (QRA) model. The objective of this study was to evaluate the risk of introduction of JEV in the US via infected mosquitoes transported in aircraft and cargo ships arriving from Asia, using a QRA model. We created a stochastic model to quantify the probability of introduction of at least one infected mosquito in the continental US via aircraft and cargo ships, per at-risk period (March to October) or year, respectively. Read More

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http://dx.doi.org/10.1016/j.prevetmed.2018.09.020DOI Listing
November 2018
4 Reads

Health Problems while Working as a Volunteer or Humanitarian Aid Worker in Post-Earthquake Nepal.

JNMA J Nepal Med Assoc 2018 Mar-Apr;56(211):691-695

CIWEC Hospital and Travel Medicine Center, Kapurdhara Marg, Kathmandu, Nepal.

Introduction: Volunteers and humanitarian aid workers working in disaster struck areas of the world are a vulnerable group of travelers. Nepal saw an influx of these humanitarian aid workers following earthquakes in April and May 2015. This study was undertaken to find out the pre-travel preparation and to estimate the risk of disease while the volunteers were deployed in Nepal. Read More

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November 2018
3 Reads

Neutralization potency of sera from Vietnamese patients with Japanese encephalitis (JE) against genotypes I and V JE viruses.

Jpn J Infect Dis 2018 Oct 31. Epub 2018 Oct 31.

Vietnam Research Station, National Institute of Hygiene and Epidemiology-Nagasaki University.

Japanese encephalitis virus (JEV) is classified into five genotypes (GI, GII, GIII, GIV, and GV), and the GI and GIII strains have been the most widely distributed in JE endemic areas. In recent years, GV JEV has been detected in China and Korea, suggesting that GV JEV may invade other JE endemic areas, including Vietnam, and that more attention should be paid to JEV strains circulating in these areas. In this study, we investigated the neutralization ability of the sera collected from 22 Vietnamese JE patients who lived in northern Vietnam against GI and GV JEV strains. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2018.232DOI Listing
October 2018
1 Read

Clinical & epidemiological significance of Kyasanur forest disease.

Indian J Med Res 2018 Aug;148(2):145-150

ICMR-National Institute of Virology, Pune, India.

Kyasanur forest disease (KFD) is a known viral haemorrhagic fever in India, for the last 60 years. However, in recent years, the change in epidemiological profile of the disease has suggested that it is now time to consider KFD as an emerging tropical disease in India. The preference should be to educate not only the villagers where it is being reported or detected but also to public health experts, veterinarians, forest officials and medical professionals to pay attention while seeing a patient overlapping with endemic diseases such as Japanese encephalitis, West Nile, dengue, chikungunya, malaria and tuberculosis. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_688_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206778PMC
August 2018
4 Reads
1.661 Impact Factor

Factors influencing the routine immunization status of children aged 2-3 years in China.

PLoS One 2018 31;13(10):e0206566. Epub 2018 Oct 31.

National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, China.

Objectives: To examine the factors associated with the routine immunization status of children aged 2-3 years in China for gaining a better understanding of the Expanded Program on Immunization and to provide evidence for formulating specific strategies to guide the allocation of health resources.

Methods: We analyzed data from 45095 children aged 2-3 years in the 2013 National Immunization Coverage Survey to identify the sociodemographic and provider-associated factors affecting the full immunization status of children. Univariate and multiple logistic regression analyses were performed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206566PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209328PMC
October 2018
2 Reads

Memory T Cells in Flavivirus Vaccination.

Vaccines (Basel) 2018 Oct 18;6(4). Epub 2018 Oct 18.

Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.

Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV). Currently, there are licensed human vaccines for DENV, JEV, TBEV and YFV, but not for WNV or ZIKV. Memory T cells play a central role in adaptive immunity and are important for host protection during flavivirus infection. Read More

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http://dx.doi.org/10.3390/vaccines6040073DOI Listing
October 2018
2 Reads

Human MxB Inhibits the Replication of Hepatitis C Virus.

J Virol 2019 Jan 10;93(1). Epub 2018 Dec 10.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China

Type I interferon (IFN) inhibits viruses by inducing the expression of antiviral proteins. The IFN-induced myxovirus resistance B (MxB) protein has been reported to inhibit a limited number of viruses, including HIV-1 and herpesviruses, but its antiviral coverage remains to be explored further. Here we show that MxB interferes with RNA replication of hepatitis C virus (HCV) and significantly inhibits viral replication in a cyclophilin A (CypA)-dependent manner. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.01285-18
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http://dx.doi.org/10.1128/JVI.01285-18DOI Listing
January 2019
7 Reads

Analysis of the Full Economic Cost for Japanese Encephalitis Under Different Risk Scenarios for Business Travelers to Asia.

J Occup Environ Med 2018 Oct 12. Epub 2018 Oct 12.

Program on Health, Work and Productivity, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center (Rogers), Department of Neurosciences, Medical University of South Carolina (Bunn III), Program on Health, Work and Productivity, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center (Lerner).

Objective: Methods for assessing the costs and benefits of administering vaccines to international business/occupational travelers, assignees and expatriates have neglected the impact of health and treatment on work productivity. The research objective is to evaluate the benefit to cost ratio of the Japanese Encephalitis (JE) vaccine for international business /occupational travelers to Asia and other endemic areas incorporating a health and productivity approach.

Methods: Costs and benefits were estimated using actuarial methods with data obtained from secondary sources describing, prevalence of infection risk and health outcomes, and business traveler demographic and travel characteristics. Read More

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http://dx.doi.org/10.1097/JOM.0000000000001474DOI Listing
October 2018

Flavivirus Receptors: Diversity, Identity, and Cell Entry.

Front Immunol 2018 26;9:2180. Epub 2018 Sep 26.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.

Flaviviruses are emerging and re-emerging arthropod-borne pathogens responsible for significant mortality and morbidity worldwide. The genus comprises more than seventy small, positive-sense, single-stranded RNA viruses, which are responsible for a spectrum of human and animal diseases ranging in symptoms from mild, influenza-like infection to fatal encephalitis and haemorrhagic fever. Despite genomic and structural similarities across the genus, infections by different flaviviruses result in disparate clinical presentations. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168832PMC
September 2018
1 Read

Community-acquired acute meningitis and encephalitis: a narrative review.

Authors:
Miles H Beaman

Med J Aust 2018 Nov 15;209(10):449-454. Epub 2018 Oct 15.

Western Diagnostic Pathology, Perth, WA

Meningitis and encephalitis are medical emergencies. Patients need prompt evaluation and immediate empiric therapy to reduce the likelihood of fatal outcomes and chronic neurological sequelae. Conjugate bacterial vaccines have significantly reduced the incidence of bacterial meningitis, especially in children. Read More

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November 2018
12 Reads

Japanese Encephalitis: A Brief Review on Indian Perspectives.

Open Virol J 2018 31;12:121-130. Epub 2018 Aug 31.

ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune-411001, India.

Introduction: Japanese encephalitis (JE) is recently declared as a notifiable disease in India due to its expanding geographical distribution. The disease notification facilitates effective implementation of preventive measures and case management.

Expalantion: JE is a vector-borne disease that can be prevented by vaccine administration. Read More

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http://benthamopen.com/FULLTEXT/TOVJ-12-121
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http://dx.doi.org/10.2174/1874357901812010121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142657PMC
August 2018
7 Reads

Zoonotic Viral Diseases of Equines and Their Impact on Human and Animal Health.

Open Virol J 2018 31;12:80-98. Epub 2018 Aug 31.

ICAR-National Research Centre on Equines, Hisar-125001, India.

Introduction: Zoonotic diseases are the infectious diseases that can be transmitted to human beings and vice versa from animals either directly or indirectly. These diseases can be caused by a range of organisms including bacteria, parasites, viruses and fungi. Viral diseases are highly infectious and capable of causing pandemics as evidenced by outbreaks of diseases like Ebola, Middle East Respiratory Syndrome, West Nile, SARS-Corona, Nipah, Hendra, Avian influenza and Swine influenza. Read More

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http://dx.doi.org/10.2174/1874357901812010080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142672PMC
August 2018
10 Reads

[Listeria Brainstem Encephalitis with Brain Abscess in an Elderly Healthy Woman].

Brain Nerve 2018 Oct;70(10):1119-1121

Department of Neurology, Japanese Red Cross Yamaguchi Hospital.

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http://dx.doi.org/10.11477/mf.1416201146DOI Listing
October 2018
3 Reads