64,131 results match your criteria Encephalitis


Severe Herpes Zoster Requiring Intravenous Antiviral Treatment in Allogeneic Hematopoietic-cell Transplantation Recipients on Standard Acyclovir Prophylaxis.

Biol Blood Marrow Transplant 2019 Apr 17. Epub 2019 Apr 17.

Brigham and Women's Hospital, Department of Infectious Diseases, Boston, Massachusetts; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, Massachusetts.

Allogeneic hematopoietic cell transplant (HCT) recipients are at increased risk for varicella zoster virus reactivation and associated complications. The incidence, timing, and risk factors for severe herpes zoster (HZ) are not well described in the era of acyclovir (ACV) prophylaxis. We performed a retrospective cohort study of all patients who underwent first allogeneic HCT from October 2006 to December 2015 at our institution. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.015DOI Listing

Encephalitis-spreading the word.

Authors:
Jules Morgan

Lancet Neurol 2019 Apr 16. Epub 2019 Apr 16.

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http://dx.doi.org/10.1016/S1474-4422(19)30155-3DOI Listing

Detection of tick-borne encephalitis virus antibodies in sera of sheep and goats in Mecklenburg-Western Pomerania (north-eastern Germany).

Ticks Tick Borne Dis 2019 Apr 14. Epub 2019 Apr 14.

Department of Tropical Medicine, Infectious Diseases and Nephrology, University of Rostock Medical School, 18055 Rostock, Germany.

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http://dx.doi.org/10.1016/j.ttbdis.2019.04.012DOI Listing

Longitudinal magnetic resonance imaging changes in Japanese encephalitis.

Brain Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatrics, Asahi General Hospital, Chiba, Japan.

Background: Japanese encephalitis is a flavivirus that can cause pandemic encephalitis, and is prevalent in Southeast Asia and Australia. Brain images of patients with Japanese encephalitis are characterized by thalamic lesions, distinct from those seen in viral encephalopathies caused by the herpes simplex virus and West Nile virus.

Aim: Herein, we describe for the first time a time-dependent magnetic resonance imaging pattern in Japanese encephalitis in a 10-month-old Japanese boy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183056
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http://dx.doi.org/10.1016/j.braindev.2019.04.005DOI Listing
April 2019
1 Read

Production and Biomedical Application of Flavivirus-like Particles.

Trends Biotechnol 2019 Apr 16. Epub 2019 Apr 16.

Department of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland. Electronic address:

Many viruses belonging to the Flaviviridae family are transmitted by invertebrate vectors. Among those transmitted by mosquitos, there are many human pathogens of great medical importance, such as Japanese encephalitis virus, West Nile virus, dengue virus, Zika virus, or yellow fever virus. Millions of people contract mosquito-borne diseases each year, leading to thousands of deaths. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01677799193007
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http://dx.doi.org/10.1016/j.tibtech.2019.03.013DOI Listing
April 2019
1 Read

Fatal Meningitis in Patient with X-Linked Chronic Granulomatous Disease Caused by Virulent Granulibacter bethesdensis.

Emerg Infect Dis 2019 May;25(5):976-979

Granulibacter bethesdensis is a pathogen reported to cause recurrent lymphadenitis exclusively in persons with chronic granulomatous disease. We report a case of fatal meningitis caused by a highly virulent G. bethesdensis strain in an adolescent in Europe who had chronic granulomatous disease. Read More

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http://dx.doi.org/10.3201/eid2505.181505DOI Listing

Novel Picornavirus in Lambs with Severe Encephalomyelitis.

Emerg Infect Dis 2019 May;25(5):963-967

Using metagenomic analysis, we identified a novel picornavirus in young preweaned lambs with neurologic signs associated with severe nonsuppurative encephalitis and sensory ganglionitis in 2016 and 2017 in the United Kingdom. In situ hybridization demonstrated intralesional neuronotropism of this virus, which was also detected in archived samples of similarly affected lambs (1998-2014). Read More

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http://dx.doi.org/10.3201/eid2505.181573DOI Listing

Neonatal Conjunctivitis Caused by Neisseria meningitidis US Urethritis Clade, New York, USA, August 2017.

Emerg Infect Dis 2019 May;25(5):972-975

We characterized a case of neonatal conjunctivitis in New York, USA, caused by Neisseria meningitidis by using whole-genome sequencing. The case was a rare occurrence, and the isolate obtained belonged to an emerging clade (N. meningitidis US nongroupable urethritis) associated with an increase in cases of urethritis since 2015. Read More

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http://dx.doi.org/10.3201/eid2505.181631DOI Listing

Editorial: Recent Advances in Psychiatry From Psycho-Neuro-Immunology Research: Autoimmune Encephalitis, Autoimmune Encephalopathy, and Mild Encephalitis.

Front Psychiatry 2019 29;10:169. Epub 2019 Mar 29.

Department of Neurology, Zucker School of Medicine at Hofstra/Northwell, Lenox Hill Hospital, New York, NY, United States.

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http://dx.doi.org/10.3389/fpsyt.2019.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455066PMC

The neurological syndromes associated with glutamic acid decarboxylase antibodies.

J Autoimmun 2019 Apr 15. Epub 2019 Apr 15.

Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA; University of Guanajuato, Mexico. Electronic address:

A number of neurological syndromes have been described in patients with positive serum antibodies (Abs) against the enzyme glutamic acid decarboxylase (GAD), the rate limiting step in the synthesis of GABA (γ-aminobutyric acid). These disorders include: classical stiff-person syndrome and variants, cerebellar ataxia, limbic and extra-limbic encephalitis, nystagmus/oculomotor dysfunction, drug-resistant epilepsy, paraneoplastic stiff-person syndrome and progressive encephalopathy with rigidity and myoclonus (PERM), the latter two are mainly related to amphiphysin and the glycine receptor Abs respectively; but patients may also have positive GAD-Abs. Although observations are consistent with an autoimmune response in these patients and there is evidence of GABAergic dysfunction in some cases; the pathogenic role of GAD-Abs in the nervous system has not been clarified and it is a matter of debate. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.04.007DOI Listing
April 2019
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Delirious Mania as a Neuropsychiatric Presentation in Patients With Anti-N-methyl-D-aspartate Receptor Encephalitis.

Psychosomatics 2019 Mar 15. Epub 2019 Mar 15.

Department of Neuropsychiatry, National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico.

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http://dx.doi.org/10.1016/j.psym.2019.03.002DOI Listing

Late Neurological Consequences of Zika Virus Infection: Risk Factors and Pharmaceutical Approaches.

Pharmaceuticals (Basel) 2019 Apr 17;12(2). Epub 2019 Apr 17.

School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21944-590, Brazil.

Zika virus (ZIKV) infection was historically considered a disease with mild symptoms and no major consequences to human health. However, several long-term, late onset, and chronic neurological complications, both in congenitally-exposed babies and in adult patients, have been reported after ZIKV infection, especially after the 2015 epidemics in the American continent. The development or severity of these conditions cannot be fully predicted, but it is possible that genetic, epigenetic, and environmental factors may contribute to determine ZIKV infection outcomes. Read More

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http://dx.doi.org/10.3390/ph12020060DOI Listing

Development of a Bead-based Immunoassay Using Virus-like Particles for Detection of Alphaviral Humoral Response.

J Virol Methods 2019 Apr 15. Epub 2019 Apr 15.

Diagnostics Systems Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA. Electronic address:

There is a pressing need for sustainable and sensitive immunodiagnostics for use in public health efforts to understand and combat the threat of endemic and emerging infectious diseases. In this proof-of-concept work, we describe an immunodiagnostic approach based on the utilization of virus-like particles (VLPs) in a magnetic bead-based platform for multiplexed detection of antiviral humoral response. A retroviral-based VLP, that presents Venezuelan equine encephalitis virus E1/E2 glycoprotein antigen on its surface, was synthesized and coupled to magnetic beads to create VLP-conjugated microspheres (VCMs). Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.04.013DOI Listing

Can be used to study parasitic disease? Internet searching on tick-borne encephalitis in Germany.

J Vector Borne Dis 2018 Oct-Dec;55(4):327-329

Sheffield Hallam University, Sheffield, U.K.

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http://dx.doi.org/10.4103/0972-9062.256571DOI Listing
April 2019
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Mosquito abundance and pig seropositivity as a correlate of Japanese encephalitis in human population in Assam, India.

J Vector Borne Dis 2018 Oct-Dec;55(4):291-296

ICAR-National Research Centre on Equines, Hisar, Haryana, India.

Background & Objectives: Assam is the most vulnerable state for Japanese encephalitis (JE) in India. The situation warrants characterization of epidemiological patterns of JE in vectors, pigs and human population. This investigation was aimed to determine the relative abundance of mosquito species and seroprevalence of JE in pigs in order to draw an epidemiological association with reported human JE cases in Assam. Read More

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http://dx.doi.org/10.4103/0972-9062.256564DOI Listing

Detection and distribution of endobacteria in populations (Diptera : Culicidae) from Metropolitan Manila, Philippines.

J Vector Borne Dis 2018 Oct-Dec;55(4):265-270

Department of Civil and Environmental Engineering, Ehime University, Matsuyama, Japan; Biological Control Research Unit, Center for Natural Science and Environmental Research, De La Salle University, Taft Ave Manila, Philippines.

Background & Objectives: Culex quinquefasciatus is a peridomestic mosquito known for its ability to transmit pathogenic diseases such as filariasis and Japanese encephalitis. The development and use of novel and innovative vector control measures such as the utilization of Wolbachia, along with the existing ones, are necessary to prevent the transmission of these diseases. Studies exploring the diversity of Wolbachia, particularly in Cx. Read More

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http://dx.doi.org/10.4103/0972-9062.256561DOI Listing
April 2019
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Acute encephalopathy associated with influenza infection: Case report and review of the literature.

Paediatr Child Health 2019 May 28;24(2):122-124. Epub 2018 Jun 28.

Departments of Pediatrics and Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia.

Influenza has been associated with neurological complications. We describe the case of a toddler who presented with symptoms and signs of acute encephalopathy and hydrocephalus. Neuroimaging demonstrated cerebral edema and multifocal diffusion restriction in the thalamus and splenium of the corpus callosum. Read More

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http://dx.doi.org/10.1093/pch/pxy085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462119PMC

Discovery of small molecule inhibitors targeting the E3 ubiquitin ligase activity of the HSV-1 ICP0 protein using an high throughput screening assay.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

University of Kansas Medical Center, Department of Microbiology, Molecular Genetics, Immunology, 3901 Rainbow Blvd, Building Hixon, room 3009, Kansas City, KS, 66160

Herpes simplex virus-1 (HSV-1) has infected more than 80% of the population. Reactivation of the virus causes diseases ranging in severity from benign cold sores to fatal encephalitis. Current treatments involve viral DNA replication inhibitors but emergence of drug resistant mutants is observed frequently, highlighting the need for novel anti-viral therapies. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.00619-19
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http://dx.doi.org/10.1128/JVI.00619-19DOI Listing
April 2019
3 Reads

Construction of the safe neutralizing assay system using pseudotyped Nipah virus and G protein-specific monoclonal antibody.

Biochem Biophys Res Commun 2019 Apr 14. Epub 2019 Apr 14.

Department of Biomedical Science and Engineering, Konkuk University, Seoul, 05029, Republic of Korea; Department of Bio-industrial Technologies, Konkuk University, Seoul, 05029, Republic of Korea. Electronic address:

Nipah virus (NiV) is a recently emerged paramyxovirus that causes acute respiratory illness and fatal encephalitis in a broad spectrum of vertebrates, including humans. Due to its high pathogenicity and mortality rates, NiV requires handling in biosafety level-4 (BSL-4) containment facilities and no effective vaccines or therapeutic agents are currently available. Since current diagnostic tests for detecting serum neutralizing antibodies against NiV mainly employ live viruses, establishment of more safe and robust alternative diagnostic methods is an essential medical requirement. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.212DOI Listing

Update in Neurocritical Care: a summary of the 2018 Paris international conference of the French Society of Intensive Care.

Ann Intensive Care 2019 Apr 16;9(1):47. Epub 2019 Apr 16.

Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium.

The 2018 Paris Intensive Care symposium entitled "Update in Neurocritical Care" was organized in Paris, June 21-22, 2018, under the auspices of the French Intensive Care Society. This 2-day post-graduate educational symposium comprised several chapters, aiming first to provide all-board intensivists with current standards for the clinical assessment of altered consciousness states (including coma and delirium) and peripheral nervous system in critically ill patients, monitoring of brain function (specifically, electro-encephalography) and best practices for sedation-analgesia-delirium management. An update on the treatment of specific severe brain pathologies-including ischaemic/haemorrhagic stroke, cerebral venous thrombosis, hypoxic-ischaemic brain injury, immune-mediated and infectious encephalitis and refractory status epilepticus-was also provided. Read More

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http://dx.doi.org/10.1186/s13613-019-0523-xDOI Listing
April 2019
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Encephalitis on deployment in Kenya: think beyond the infections.

J R Army Med Corps 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, Queen Elizabeth Hospital Birmingham, Birmingham, UK.

A 34-year-old female soldier presented with fever and behavioural changes while deployed in Kenya and was diagnosed with encephalitis. The patient underwent urgent aeromedical evacuation to the Queen Elizabeth Hospital, Birmingham for further management. Microbiology tests excluded common infectious causes that are endemic in the East Africa region. Read More

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http://dx.doi.org/10.1136/jramc-2018-001115DOI Listing
April 2019
3 Reads

Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid.

Genome Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California 94143, USA.

Metagenomic next-generation sequencing (mNGS) for pan-pathogen detection has been successfully tested in proof-of-concept case studies in patients with acute illness of unknown etiology but to date has been largely confined to research settings. Here, we developed and validated a clinical mNGS assay for diagnosis of infectious causes of meningitis and encephalitis from cerebrospinal fluid (CSF) in a licensed microbiology laboratory. A customized bioinformatics pipeline, SURPI+, was developed to rapidly analyze mNGS data, generate an automated summary of detected pathogens, and provide a graphical user interface for evaluating and interpreting results. Read More

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http://dx.doi.org/10.1101/gr.238170.118DOI Listing

Anti--methyl-d-aspartate receptor encephalitis in an older patient presenting with a rapid onset of delusions and amnesia.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Clinic for Geriatric Psychiatry, Psychiatric University Clinic, Zurich, Switzerland.

We present the case of a 77-year-old patient with a rapid onset of delusions, amnesia, agitation, insomnia and no previous psychiatric history, who was diagnosed with anti--methyl-d-aspartate receptor encephalitis. This case report highlights the importance of including autoimmune encephalitis in the differential diagnosis of older patients presenting with rapid onset psychiatric episodes. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22851
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http://dx.doi.org/10.1136/bcr-2018-228512DOI Listing
April 2019
1 Read

Acute flaccid paralysis in North East Delta, Egypt: A retrospective analysis of prospectively collected surveillance data.

J Infect Public Health 2019 Apr 13. Epub 2019 Apr 13.

Ministry of Health, Egypt. Electronic address:

Background: Effective acute flaccid paralysis (AFP) surveillance is crucial in countries approaching the final phase of polio eradication. Thus this study was conducted to highlight the epidemiological pattern of AFP as a surveillance tool for polio in Egypt.

Methods: A record-based descriptive study was conducted to include all AFP cases (599) reported in the last 9 years starting from January 2009 to December 2017 in Dakahlia, North East of Delta, Egypt. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18760341193012
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http://dx.doi.org/10.1016/j.jiph.2019.03.016DOI Listing
April 2019
2 Reads

Serological Diagnosis of Lentivirus Infection in Goats Raised in Algeria.

J Vet Res 2019 Mar 22;63(1):27-33. Epub 2019 Mar 22.

INRA/UGA USC 1450, Pathogenesis and Lentivirus Vaccination Laboratory, PAVAL Lab., Université Grenoble Alpes, 38041, Grenoble Cedex 9, France.

Introduction: Infection of goats with caprine arthritis encephalitis virus (CAEV) has been detected in variable proportions in many countries all over the world. Here, we investigated the seroprevalence of CAEV in goats raised in Algeria.

Material And Methods: A serological survey was performed on serum samples from 1,313 goats, including the local breeds (Arabia and Dwarf of Kabylia) and imported European breeds (Alpine and Saanen). Read More

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http://dx.doi.org/10.2478/jvetres-2019-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458564PMC
March 2019
1 Read

Immunoneuropsychiatry - novel perspectives on brain disorders.

Nat Rev Neurol 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Immune processes have a vital role in CNS homeostasis, resilience and brain reserve. Our cognitive and social abilities rely on a highly sensitive and fine-tuned equilibrium of immune responses that involve both innate and adaptive immunity. Autoimmunity, chronic inflammation, infection and psychosocial stress can tip the scales towards disruption of higher-order networks. Read More

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http://www.nature.com/articles/s41582-019-0174-4
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http://dx.doi.org/10.1038/s41582-019-0174-4DOI Listing
April 2019
7 Reads

Development and evaluation of lateral flow assay for sero-diagnosis of Japanese encephalitis in swine.

Anim Biotechnol 2019 Apr 15:1-7. Epub 2019 Apr 15.

d ICAR , Krishi Bhavan , New Delhi , India.

Japanese encephalitis (JE) is a re-emerging mosquito-borne zoonotic flaviviral disease. Swine sero-convert 2-3 weeks before infection occurs in humans and thus serves as a suitable sentinel for JE surveillance and outbreak prediction in human population. The present study was conducted with the objective of developing a lateral flow assay (LFA) for detecting JEV antibodies in swine sera. Read More

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http://dx.doi.org/10.1080/10495398.2019.1602539DOI Listing

Model of Risk of Exposure to Lyme Borreliosis and Tick-Borne Encephalitis Virus-Infected Ticks in the Border Area of the Czech Republic (South Bohemia) and Germany (Lower Bavaria and Upper Palatinate).

Int J Environ Res Public Health 2019 Apr 2;16(7). Epub 2019 Apr 2.

Institute of Parasitology, Biology Centre, Academy of Sciences of Czech Republic, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic.

In Europe, Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are the two vector-borne diseases with the largest impact on human health. Based on data on the density of host-seeking ticks and pathogen prevalence and using a variety of environmental data, we have created an acarological risk model for a region where both diseases are endemic (Czech Republic-South Bohemia and Germany-Lower Bavaria, Upper Palatinate). The data on tick density were acquired by flagging 50 sampling sites three times in a single season. Read More

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http://dx.doi.org/10.3390/ijerph16071173DOI Listing
April 2019
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Low population Japanese encephalitis virus (JEV) seroprevalence in Udayapur district, Nepal, three years after a JE vaccination programme: A case for further catch up campaigns?

PLoS Negl Trop Dis 2019 Apr 15;13(4):e0007269. Epub 2019 Apr 15.

Institute of Infection and Global Health and National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, United Kingdom.

The live attenuated Japanese encephalitis (JE) vaccine SA14-14-2 has been used in Nepal for catch-up campaigns and is now included in the routine immunisation schedule. Previous studies have shown good vaccine efficacy after one dose in districts with a high incidence of JE. The first well-documented dengue outbreak occurred in Nepal in 2006 with ongoing cases now thought to be secondary to migration from India. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007269DOI Listing
April 2019
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High prevalence of Sarcocystis calchasi in racing pigeon flocks in Germany.

PLoS One 2019 15;14(4):e0215241. Epub 2019 Apr 15.

Clinic for Birds, Reptiles, Amphibians and Fish, Justus Liebig University Giessen, Giessen, Germany.

The apicomplexan parasite Sarcocystis calchasi (Coccidia: Eimeriorina: Sarcocystidae) is the causative agent of Pigeon Protozoal Encephalitis (PPE) and infects birds of the orders Columbiformes, Piciformes and Psittaciformes. Accipiter hawks (Aves: Accipitriformes) are the definitive hosts of this parasite. Infections of S. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215241PLOS
April 2019
3 Reads

Henipavirus Infection of the Central Nervous System.

Pathog Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Pathology, University of Texas Medical Branch, Galveston, USA.

Nipah virus and Hendra virus are highly pathogenic zoonotic viruses of the genus Henipavirus, family Paramyxoviridae. These viruses were first identified as the causative agents of severe respiratory and encephalitic disease in the 1990s across Australia and Southern Asia with mortality rates reaching up to 75%. While outbreaks of Nipah and Hendra virus infections remain rare and sporadic, there is concern that Nipah virus has pandemic potential. Read More

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http://dx.doi.org/10.1093/femspd/ftz023DOI Listing

Efficacy of acyclovir for herpes simplex encephalitis: A protocol for a systematic review of randomized controlled trial.

Authors:
Wei Wang Meng Ji

Medicine (Baltimore) 2019 Apr;98(15):e15254

Background: Clinical researches indicate that acyclovir can be used to herpes simplex encephalitis (HSE). However, no systematic review has explored its efficacy for the treatment of HSE. Therefore, this study systematically will investigate the efficacy and safety of acyclovir for patients with HSE. Read More

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http://dx.doi.org/10.1097/MD.0000000000015254DOI Listing
April 2019
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Evaluation of the adjunctive effect of Xing Nao Jing Injection for viral encephalitis: A systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2019 Apr;98(15):e15181

Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Background: To systematically evaluate the effect and safety of Xing Nao Jing (XNJ) injection as an add-on treatment on the treatment for viral encephalitis (VE).

Methods: Trials assessing the adjunctive effectiveness of XNJ injection for VE were searched from 4 electronic databases from inception to October 31, 2018. Two authors independently extracted data and assessed risk of bias. Read More

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http://dx.doi.org/10.1097/MD.0000000000015181DOI Listing

Hemorrhagic encephalitis in a patient with neuromyelitis optica: A case report.

J Spinal Cord Med 2019 Apr 15:1-4. Epub 2019 Apr 15.

a Department of Neurology , West China Hospital, Sichuan University , Chengdu , People's Republic of China.

Context: Neuromyelitis optica (NMO) is a severe, inflammatory, relapsing disease with a predilection for the optic nerves and spinal cord. The manifestations of brain involvement take various forms, but the occurrence of intracerebral hemorrhage is seldom observed.

Finding: We report the case of a patient with NMO who presented with hemorrhagic encephalitis during the course of the disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/10790268.2019.1
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http://dx.doi.org/10.1080/10790268.2019.1603435DOI Listing
April 2019
2 Reads

Specific detection and differentiation of tick-borne encephalitis and West Nile virus induced IgG antibodies in humans and horses.

Transbound Emerg Dis 2019 Apr 15. Epub 2019 Apr 15.

Fraunhofer Institute for Cell Therapy and Immunology, Department of Immunology, Perlickstrasse 1, 04103, Leipzig, Germany.

Tick-borne encephalitis virus (TBEV) and West Nile virus (WNV) are important arthropod-borne zoonotic flaviviruses. Due to the emergence of WNV in TBEV-endemic regions co-circulation of both viruses is increasing. Flaviviruses are structurally highly similar, which leads to cross-reacting antibodies upon infection. Read More

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http://dx.doi.org/10.1111/tbed.13205DOI Listing
April 2019
1 Read

Case of Trichophyton tonsurans infection which emerged after using corticosteroid to treat herpetic encephalitis.

J Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Kanazawa Medical University, Ishikawa, Japan.

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http://dx.doi.org/10.1111/1346-8138.14886DOI Listing

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors.

Transl Neurodegener 2019 3;8:11. Epub 2019 Apr 3.

1Department of Neurology, University Hospital Schleswig Holstein, Arnold-Heller Str. 3, 24105 Kiel, Germany.

Background: IgG-class autoantibodies to N-Methyl-D-Aspartate (NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis. Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting results. We measured NMDA antibodies in a large, well phenotyped sample of Parkinson patients without and with cognitive impairment ( = 296) and controls ( = 295) free of neuropsychiatric disease. Read More

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https://translationalneurodegeneration.biomedcentral.com/art
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http://dx.doi.org/10.1186/s40035-019-0153-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446289PMC
April 2019
2 Reads

Zika Virus Infection Disrupts Astrocytic Proteins Involved in Synapse Control and Axon Guidance.

Front Microbiol 2019 26;10:596. Epub 2019 Mar 26.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.

The first human Zika virus (ZIKV) outbreak was reported in Micronesia in 2007, followed by one in Brazil in 2015. Recent studies have reported cases in Europe, Oceania and Latin America. In 2016, ZIKV transmission was also reported in the US and the World Health Organization declared it a Public Health Emergency of International Concern. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448030PMC
March 2019
1 Read

Pathways Exploited by Flaviviruses to Counteract the Blood-Brain Barrier and Invade the Central Nervous System.

Front Microbiol 2019 28;10:525. Epub 2019 Mar 28.

Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Human infection by different flaviviruses may cause severe neurologic syndromes, through pathogenic mechanisms that are still largely unknown. Japanese encephalitis virus (JEV), West Nile virus (WNV), Zika virus (ZIKV), yellow fever virus (YFV), dengue virus (DENV), and tick-borne encephalitis virus (TBEV) are believed to reach the central nervous system by a hematogenous route, upon crossing the blood-brain barrier. Although the disruption of BBB during flavivirus infection has been largely evidenced in experimental models, the relevance of BBB breakdown for virus entering the brain was not completely elucidated. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00525
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http://dx.doi.org/10.3389/fmicb.2019.00525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447710PMC
March 2019
2 Reads

Anti-N-Methyl-D-Aspartate Receptor Encephalitis in a Patient With Antithyroid Peroxidase Antibodies and a Parotid Pleomorphic Adenoma.

Ochsner J 2019 ;19(1):59-62

The University of Queensland Faculty of Medicine, Ochsner Clinical School, New Orleans, LA.

Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is an autoimmune disorder first described in 2007. It can cause severe neurologic and psychiatric symptoms, and patients often are misdiagnosed with a primary psychiatric disorder. Anti-NMDA-R encephalitis is an important differential diagnosis of psychosis, as the condition can be treated with the appropriate therapy. Read More

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http://www.ochsnerjournal.org/lookup/doi/10.31486/toj.18.011
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http://dx.doi.org/10.31486/toj.18.0115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447211PMC
January 2019
6 Reads

Atypical Limbic Encephalitis and its Complex Psychiatric Presentations: Implications for Diagnosis and Management.

Indian J Psychol Med 2019 Mar-Apr;41(2):187-190

Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_233_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436404PMC

Hashimoto's Encephalopathy Presenting with Smoldering Limbic Encephalitis.

Intern Med 2019 15;58(8):1167-1172. Epub 2019 Apr 15.

Department of Neurology, Kyoto University Graduate School of Medicine, Japan.

Hashimoto's encephalopathy (HE) is a steroid-responsive autoimmune encephalopathy associated with Hashimoto thyroiditis. We herein report a case of HE manifesting "smoldering" limbic encephalitis with persisting symptoms and abnormalities on examinations. Although our patient experienced partial clinical remission after treatment, hippocampal hypermetabolism on [F] fluorodeoxyglucose positron emission tomography (FDG-PET) and subclinical seizures on video electroencephalography persisted. Read More

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http://dx.doi.org/10.2169/internalmedicine.1289-18DOI Listing
April 2019
1 Read

Arboviral diseases and malaria in Australia, 2014–15: Annual report of the National Arbovirus and Malaria Advisory Committee

Commun Dis Intell (2018) 2019 Apr 15;43. Epub 2019 Apr 15.

Royal Darwin Hospital Northern Territory; Menzies School of Health Research, Darwin, Northern Territory

This report describes the epidemiology of mosquito-borne diseases of public health importance in Australia during the 2014–15 season (1 July 2014 to 30 June 2015) and includes data from human notifications, sentinel chicken, vector and virus surveillance programs. The National Notifiable Diseases Surveillance System received notifications for 12,849 cases of disease transmitted by mosquitoes during the 2014–15 season. The Australasian alphaviruses Barmah Forest virus and Ross River virus accounted for 83% (n=10,723) of notifications. Read More

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April 2019
3 Reads

Red flags for suspecting anti-NMDAr encephalitis in a first psychotic episode: report of two cases.

Rev Colomb Psiquiatr 2019 Apr - Jun;48(2):127-130. Epub 2017 Dec 11.

Unidad de Neurología, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.

Anti-N-methyl-D-Aspartate receptor (NMDAr) encephalitis is a recently described clinical entity with an increasing number of reported cases. Psychiatric symptoms in the early stages of the disease constitute a diagnostic challenge for the treating physician. We present two clinical cases: clinical case 1, a 26-year-old man, and clinical case 2, an 18-year-old man; both presented with a first episode of psychosis and were hospitalized as psychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.rcp.2017.10.002DOI Listing
December 2017
1 Read

Dysregulation of sonic hedgehog pathway and pericytes in the brain after lentiviral infection.

J Neuroinflammation 2019 Apr 13;16(1):86. Epub 2019 Apr 13.

Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W. Olney Road, Lewis Hall 3174, Norfolk, VA, 23501, USA.

Background: Impairment of the blood-brain barrier (BBB) has been associated with cognitive decline in many CNS diseases, including HIV-associated neurocognitive disorders (HAND). Recent research suggests an important role for the Sonic hedgehog (Shh) signaling pathway in the maintenance of BBB integrity under both physiological and pathological conditions.

Methods: In the present study, we sought to examine the expression of Shh and its downstream effectors in relation to brain pericytes and BBB integrity in HIV-infected humans and rhesus macaques infected with simian immunodeficiency virus (SIV), an animal model of HIV infection and CNS disease. Read More

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http://dx.doi.org/10.1186/s12974-019-1463-yDOI Listing
April 2019
1 Read

Long-term seizure outcome in patients with status epilepticus due to acute encephalitis.

Seizure 2019 Apr 8;69:70-75. Epub 2019 Apr 8.

Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

Purpose: To investigate the long-term seizure outcome in patients with convulsive status epilepticus (CSE) due to acute encephalitis and identify early predictors for terminal seizure remission.

Methods: Based on a prospective registry of CSE, consecutive patients with CSE due to acute encephalitis were enrolled from July 2009 to November 2017, with follow-up ending in November 2018. Variables during hospital stay, seizure outcomes within 1 month after status epilepticus (SE), and seizure outcomes within 3 months after acute phase of encephalitis were assessed for predicting terminal seizure freedom. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311193010
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http://dx.doi.org/10.1016/j.seizure.2019.04.005DOI Listing
April 2019
2 Reads

013 The role of B cell monotherapy in the treatment of auto-immune encephalitis.

Authors:
Clive Kelly

Rheumatology (Oxford) 2019 Apr 13. Epub 2019 Apr 13.

Medicine, Queen Elizabeth Hospital, Gateshead, UNITED KINGDOM.

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/kez145DOI Listing
April 2019
3 Reads

[Meningitis/Encephalitis diagnosis in ICU using Multiplex PCR system: Is it time of change?]

Rev Esp Quimioter 2019 Apr 11. Epub 2019 Apr 11.

Lucía López-Amor, Servicio de Medicina Intensiva. Hospital Universitario Central de Asturias. Avenida de Roma s/n 33011 Oviedo. Spain.

Objective: To evaluate the clinical impact of Meningitis/Encephalitis FilmArray® panel for the diagnosis of cerebral nervous system infection and to compare the results (including time for diagnosis) with those obtained by conventional microbiological techniques.

Methods: A prospective observational study in an Intensive Care Unit of adults from a tertiary hospital was carried out. Cerebrospinal fluid from all patients was taken by lumbar puncture and assessed by the meningitis/encephalitis FilmArray® panel ME, cytochemical study, Gram, and conventional microbiological cultures. Read More

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April 2019
3 Reads

[Recurrent vomiting and headaches in a 26-year-old male patient].

Internist (Berl) 2019 Apr 12. Epub 2019 Apr 12.

I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.

This article reports the case of a 26-year-old male patient with recurrent emesis and headache due to central nervous system tuberculosis. The thoracic computed tomography showed bilateral disseminated pulmonary micronodular infiltrates and a cavern connecting to the bronchial system. The cranial magnetic resonance imaging showed multiple supratentorial and infratentorial microabscesses with concomitant meningitis. Read More

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http://link.springer.com/10.1007/s00108-019-0597-4
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http://dx.doi.org/10.1007/s00108-019-0597-4DOI Listing
April 2019
2 Reads