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J Pak Med Assoc 2022 Jun;72(6):1133-1136

Department of Clinical Care Medicine, Beijing Luhe Hospital, Capital Medical University, China.

Objective: To explore correlation of serum markers human neutrophil lipocalin and C-reactive protein with acute cholecystitis associated with bacterial infection, and to evaluate the diagnostic value of the markers.

Methods: The cross-sectional study was conducted from January 2018 to April 2020 at the Beijing Luhe Hospital, Capital Medical University, Beijing, China, and comprised acute cholecystitis patients who were divided into bacterial infection group A and non-bacterial infection group B. Serum human neutrophil lipocalin and C-reactive protein were measured for both the groups. Read More

West Afr J Med 2022 Jun;39(6):568-572

Department of Internal Medicine, Lagos University Teaching Hospital, Idi-Araba, Lagos State, Nigeria.

Background: Intestinal helminthiases are public health problems of children in developing countries of the world and account for significant morbidity as it results in stunted growth, intestinal obstruction, anaemia, cognitive impairment, acute pancreatitis, acute cholecystitis and rectal prolapse. This study assessed intestinal helminths, infection intensity and symptoms in primary school children in Ile-Ife.

Methods: It was a cross sectional study. Read More

World J Surg 2022 Jun 24. Epub 2022 Jun 24.

Department of Surgery, Division of Acute Care Surgery and Surgical Critical Care, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 650W, Los Angeles, CA, 90048, USA.

Cureus 2022 May 21;14(5):e25180. Epub 2022 May 21.

Pediatrics, Hospital de Cascais Dr. José de Almeida, Lisbon, PRT.

Acute cholecystitis is an exceedingly rare condition in young children; nevertheless, it should be considered while investigating an acute abdomen. We report a case of a five-month-old male who presented to the pediatric emergency department with inconsolable crying, decreased oral intake, vomiting, diarrhea, and a tender right upper quadrant of the abdomen. Laboratory studies revealed elevated gamma-glutamyl transferase and alkaline phosphatase and the abdominal ultrasound was suggestive of acute calculous cholecystitis. Read More

Medicina (Kaunas) 2022 Jun 9;58(6). Epub 2022 Jun 9.

Department of Surgery, AHEPA General University Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Acute cholecystitis, which is usually associated with gallstones is one of the most common surgical causes of emergency hospital admission and may be further complicated by mural necrosis, perforation and abscess formation. Perforation of the gallbladder is a relatively uncommon complication of acute cholecystitis (0.8-3. Read More

BJS Open 2022 May;6(3)

Comput Math Methods Med 2022 13;2022:8696084. Epub 2022 Jun 13.

Intensive Care Unit, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, China.

Objective: To explore the effect of MDT (multidisciplinary team) collaborative nursing combined with hierarchical nursing management mode on the quality of life and comfort of patients with gallbladder stones combined with acute cholecystitis after surgery.

Methods: A total of 120 patients with gallbladder stones and acute cholecystitis who were treated in our hospital from March 2019 to March 2021 were selected as prospective research objects. According to the order of care, they were divided into control group and observation group with 60 cases each. Read More

Ann Med Surg (Lond) 2022 Jun 29;78:103668. Epub 2022 Apr 29.

Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Italy.

The existence of a close association between disease of the biliary tract and disease of the heart is known from the mists of time. Acute acalculous cholecystitis (AAC) can be defined as an acute necro inflammatory disease of the gallbladder in the absence of cholelithiasis. AAC is a challenging diagnosis. Read More

World J Gastrointest Surg 2022 May;14(5):470-481

Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.

Background: Cholecystectomy is the preferred treatment option for symptomatic gallstones. However, another option is gallbladder-preserving cholecystolithotomy which preserves the normal physiological functions of the gallbladder in patients desiring to avoid surgical resection.

Aim: To compare the feasibility, safety and effectiveness of pure natural orifice transluminal endoscopic surgery (NOTES) gallbladder-preserving cholecystolithotomy laparoscopic cholecystectomy (LC) for symptomatic gallstones. Read More

Arq Bras Cir Dig 2022 17;35:e1655. Epub 2022 Jun 17.

Department of Surgery, Federal University of Parana - Curitiba - Parana - Brazil.

Aim: One of the ways to avoid infection after surgical procedures is through antibiotic prophylaxis. This occurs in cholecystectomies with certain risk factors for infection. However, some guidelines suggest the use of antibiotic prophylaxis for all cholecystectomies, although current evidence does not indicate any advantage of this practice in the absence of risk factors. Read More

Arq Bras Cir Dig 2022 17;35:e1652. Epub 2022 Jun 17.

Universidade do Estado da Bahia, Departamento de Ciências da Vida - Salvador - Bahia - Brasil.

Aim: Gallbladder diseases (GBD) are one of the most common medical conditions requiring surgical intervention, both electively and urgently. It is widely accepted that sex and ethnic characteristics mighty influence both prevalence and outcomes. This study aimed to evaluate the differences on distributions of gender and ethnicity related to the epidemiology of GBD in the Brazilian public health system. Read More

Int J Surg Case Rep 2022 Jun 14;96:107308. Epub 2022 Jun 14.

Sri Ramachandra Institute of Higher Education and Research, No.1 Ramachandra Nagar, Porur, Chennai, Tamil Nadu 600116, India.

Introduction And Importance: Fascia Lata is one of the oldest materials used in the repair of inguinal hernia. It lost its popularity following the advent of meshes, mainly Tantalum and Marlex. However, the use of synthetic meshes in infected scenario is controversial. Read More

N Z Med J 2022 May 20;135(1555):48-58. Epub 2022 May 20.

Consultant General Surgeon, Northland District Health Board; Associate Professor, Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland.

Aim: Acute cholecystitis is a common reason for emergency admission. Rurality and ethnicity are associated with poorer surgical outcomes, but data in benign disease is sparse. This study aims to assess the effect of rurality and ethnicity on the severity, management, and outcomes of acute cholecystitis. Read More

Pediatr Int 2022 Jan;64(1):e15220

Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.

Background: Asymptomatic gallbladder stones may be detected with ultrasound; some gallstones produce symptomatic diseases, such as cholecystitis, cholangitis, or pancreatitis. Identifying the clinical features of symptomatic gallstones may help prevent severe complications by providing intervention for asymptomatic gallstones. We aimed to investigate risk factors associated with developing symptomatic disease in pediatric patients with severe motor and intellectual disabilities (SMID). Read More

J Robot Surg 2022 Jun 21. Epub 2022 Jun 21.

Department of General, Visceral and Oncologic Surgery, Wetzlar Hospital and Clinics, Forsthausstr. 1, 35578, Wetzlar, Germany.

Robotically assisted operations are the state of the art in laparoscopic general surgery. They are established predominantly for elective operations. Since laparoscopy is widely used in urgent general surgery, the significance of robotic assistance in urgent operations is of interest. Read More

Int Microbiol 2022 Jun 20. Epub 2022 Jun 20.

Clinical Laboratory of Integrative Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian, China.

Background/aims: The aim was to characterize a bacterium causing intestinal mucosal barrier damage and to identify the possible invasion mechanism.

Materials And Methods: The intestinal permeability and tight junction protein levels were detected in guinea pigs infected with Escherichia coli D-09 via immunofluorescence analysis and western blotting. In order to explain this invasion mechanism at the gene level, whole genome sequencing analysis was performed on this bacterium. Read More

Lakartidningen 2022 Jun 20;119. Epub 2022 Jun 20.

professor, överläkare, institutionen för kirurgisk och perioperativ vetenskap, Umeå universitet; kirurgkliniken, Sunderby sjukhus, Luleå.

The covid-19 pandemic has necessitated reallocation of health care resources. This has raised concerns about the risks associated with postponing surgery for benign conditions that are given low priority. Data from the population-based Swedish National Register for Gallstone Surgery (GallRiks) show that the total number of procedures carried out during the initial months of each wave of the pandemic decreased. Read More

Ann Transl Med 2022 May;10(10):616

Department of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.

Background: Gallbladder torsion is very rare and easily misdiagnosed as biliary disease. It is defined as the rotation of the gallbladder along the axis of the cystic pedicle on the mesentery. As gallbladder rotation involves the gallbladder artery, the blood supply is blocked, resulting in gallbladder ischemia and eventual necrosis. Read More

Cureus 2022 May 17;14(5):e25072. Epub 2022 May 17.

Gastroenterology, Chiba University, Chiba, JPN.

Background and objective In this study, we aimed to evaluate the efficacy and safety of a single pigtail stent made by cutting a nasobiliary drainage tube (NBD stent) by comparing the clinical outcomes of using an NBD stent and those of using a ready-made double pigtail stent (RDP stent) in endoscopic gallbladder stenting (EGBS) for acute cholecystitis. Materials and methods This was a single-center retrospective study involving 20 cases that had technical success with EGBS for acute cholecystitis; the patients were divided into two groups: those using NBD stent (NBD group) and those using RDP stent (RDP group). The baseline characteristics and clinical outcomes were compared between the two groups. Read More

J Ethnopharmacol 2022 Jun 16;296:115471. Epub 2022 Jun 16.

Key Laboratory of Chemistry of Plant Resources in Arid Regions, State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing Road South 40-1, Urumqi, 830011, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Ethnopharmacological Relevance: Chamomile (Matricaria chamomilla L.) is a popular herbal tea for the treatment of hepatitis and cholecystitis in traditional Uygur medicines.

Aim Of The Study: To investigate the anti-inflammatory activity and chemical composition of M. Read More

Int J Surg Case Rep 2022 Jun 8;96:107273. Epub 2022 Jun 8.

Department of General Surgery A, Hospital La Rabta, Tunis, Tunisia; University Tunis El Manar, Faculty of Medicine of Tunis, Tunisia.

Background: Laparoscopic cholecystectomy is the standard treatment for acute cholecystitis. Cholecystostomy is a good option in patients with significant comorbidities. We report a case of a patient having had a percutaneous cholecystostomy for acute cholecystitis complicated with haemobilia and acute cholangitis. Read More

Commun Biol 2022 Jun 16;5(1):599. Epub 2022 Jun 16.

McMaster Ancient DNA Centre, Departments of Anthropology and Biochemistry, McMaster University, Hamilton, Canada.

Escherichia coli - one of the most characterized bacteria and a major public health concern - remains invisible across the temporal landscape. Here, we present the meticulous reconstruction of the first ancient E. coli genome from a 16 century gallstone from an Italian mummy with chronic cholecystitis. Read More

World J Emerg Surg 2022 Jun 16;17(1):34. Epub 2022 Jun 16.

Department of General, Visceral, Thoracic, Transplant and Pediatric Surgery, University Hospital of Giessen, Rudolf-Buchheim-Strasse 7, 35392, Giessen, Germany.

Background: The SARS-CoV-2 pandemic is still ongoing and a major challenge for health care services worldwide. In the first WSES COVID-19 emergency surgery survey, a strong negative impact on emergency surgery (ES) had been described already early in the pandemic situation. However, the knowledge is limited about current effects of the pandemic on patient flow through emergency rooms, daily routine and decision making in ES as well as their changes over time during the last two pandemic years. Read More

Endosc Ultrasound 2022 Jun 8. Epub 2022 Jun 8.

Department of Gastroenterology, Endoscopic Center, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China.

Background And Objectives: EUS-guided gallbladder drainage (EUS-GBD) has become one of the recommended treatments for patients with high-risk acute cholecystitis. However, the gallbladder reportedly collapsed due to bile leakage, which was a disadvantage that affects the surgical success rate. Different electrocautery-enhanced delivery of the lumen-apposing metal stents (ECE-LAMSs) using suitable power levels in electrosurgical workstations can increase the surgical success rate and reduce trauma. Read More

Wideochir Inne Tech Maloinwazyjne 2022 Jun 16;17(2):303-308. Epub 2022 Mar 16.

Department of Vascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Introduction: In some cases, laparoscopic cholecystectomy (LC) may be very difficult and easily converted to laparotomy, causing many complications to patients and prolonging the prognosis time. Thus, to evaluate the difficulty of LC before operation is extremely important.

Aim: To explore the risk factors of difficult cholecystectomy (DC) and to establish a risk prediction model of DC. Read More

EClinicalMedicine 2022 Jun 13;48:101431. Epub 2022 May 13.

The First School of Clinical Medicne, Lanzhou University, Lanzhou,730030, Gansu, China.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) is an established treatment for common bile duct (CBD) stones. Post- ERCP cholecystitis (PEC) is a known complication of such procedure and there are no effective models and clinical applicable tools for PEC prediction.

Methods: A random forest (RF) machine learning model was developed to predict PEC. Read More

Clin Imaging 2022 Jun 8;89:55-60. Epub 2022 Jun 8.

Division of Surgery, Fujinomiya City General Hospital, Shizuoka, Japan.

Purpose: Retained stones (RS) in the common bile duct (CBD) are one of the major problems after laparoscopic cholecystectomy and usually require endoscopic treatment. However, few reports have investigated risk factors for the development of RS in the CBD.

Methods: A total of 325 patients with acute cholecystitis underwent laparoscopic cholecystectomy at our hospital between January 2013 and Jury 2021. Read More

Intractable Rare Dis Res 2022 May;11(2):52-62

Department of Microbiology, Sarsuna College (under Calcutta University), Kolkata, India.

The human body harbors approximately 10 cells belonging to a diverse group of microorganisms. Bacteria outnumbers protozoa, fungi and viruses inhabiting our gastrointestinal tract (GIT), commonly referred to as the "human gut microbiome". Dysbiosis occurs when the balanced relationship between the host and the gut microbiota is disrupted, altering the usual microbial population there. Read More

Surg Case Rep 2022 Jun 14;8(1):111. Epub 2022 Jun 14.

Department of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, 3-39-22, Showa-machi, Maebashi, Gunma, Japan.

Background: Although visceral aneurysms are relatively rare, it can be life-threatening in case it ruptures. We report a case of Mirizzi syndrome accompanied by a pseudoaneurysm that ruptured into the gallbladder.

Case Presentation: The patient was a 73-year-old woman with persistent gastrointestinal bleeding and progressive jaundice. Read More

Surg Endosc 2022 Jun 13. Epub 2022 Jun 13.

Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.

Background: The SAGES International Proctoring Course for Laparoscopic Cholecystecomy accepts applications from low to middle-income countries for SAGES faculty to train local surgeons. A regional public hospital in the 10th most populous city in the Philippines was one of the chosen sites for the 1-week course in 2010. Two SAGES surgeons and one nurse trained two local surgeons and four nurses identified by the hospital director. Read More