35,159 results match your criteria Emphysema


A Functional Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphism is Associated with Reduced Diffusing Capacity.

Am J Physiol Lung Cell Mol Physiol 2018 Dec 6. Epub 2018 Dec 6.

Pulmonary and Critical Care, Yale University School of Medicine, United States.

Cigarette smoke exposure is the leading modifiable risk factor for COPD, however the clinical and pathologic consequences of chronic cigarette smoke exposure are variable amongst smokers. MIF (Macrophage Migration Inhibitory Factor) is a pleiotropic cytokine implicated in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). Within the promoter of the MIF gene is a functional polymorphism that regulates MIF expression (-794 CATT microsatellite repeat) ( rs5844572). Read More

View Article
December 2018

Magnetic resonance imaging of the time course of hyperpolarized Xe gas exchange in the human lungs and heart.

Eur Radiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.

Purpose: To perform magnetic resonance imaging (MRI), human lung imaging, and quantification of the gas-transfer dynamics of hyperpolarized xenon-129 (HPX) from the alveoli into the blood plasma.

Materials And Methods: HPX MRI with iterative decomposition of water and fat with echo asymmetry and least-square estimation (IDEAL) approach were used with multi-interleaved spiral k-space sampling to obtain HPX gas and dissolved phase images. IDEAL time-series images were then obtained from ten subjects including six normal subjects and four patients with pulmonary emphysema to test the feasibility of the proposed technique for capturing xenon-129 gas-transfer dynamics (XGTD). Read More

View Article
December 2018
1 Read

[The Pathogenesis of Pulmonary Emphysema - Laennec was right!]

Pneumologie 2018 Dec 3. Epub 2018 Dec 3.

Clinical Research, Thora Tech GmbH, Anwenderzentrum für Medizintechnik, Gießen.

Pulmonary emphysema is characterised by irreversible destruction and enlargement of alveolar structure distal to terminal bronchioles. Small conducting airways < 2 mm in diameter are the major site of chronic airway inflammation and obstruction in COPD patients. 80 - 90 % of the last generation of small conducting airways, the terminal bronchioles, are destroyed in patients with very severe COPD. Read More

View Article
December 2018
1 Read

Quantitative severity of pulmonary emphysema as a prognostic factor for recurrence in patients with surgically resected non-small cell lung cancer.

Thorac Cancer 2018 Dec 2. Epub 2018 Dec 2.

Division of Pulmonology and Allergy, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, South Korea.

Background: Pulmonary emphysema is a major component of chronic obstructive pulmonary disease and lung cancer. However the prognostic significance of quantitative emphysema severity in patients with lung cancer is unclear. We analyzed whether numerical emphysema value is a prognostic factor for recurrence in patients with surgically resected non-small cell lung cancer. Read More

View Article
December 2018

The role of indocyanine green fluorescence for intersegmental plane identification during video-assisted thoracoscopic surgery segmentectomies.

J Thorac Dis 2018 Nov;10(Suppl 31):S3704-S3711

Department of Thoracic Surgery, Federal Hospital #122, Saint Petersburg, Russia.

Background: According to recent studies, thoracoscopic segmentectomy is an acceptable alternative to lobectomy for treating different lung diseases. This approach appears to have equivalent rates of postoperative morbidity with potentially similar long-term results even in selected lung cancer patients. At the same time, surgical success is highly dependent on intraoperative interpretation of segmental anatomy. Read More

View Article
November 2018

An unusual complication of pigtail catheter insertion.

J Thorac Dis 2018 Oct;10(10):5964-5967

Department of Pulmonary/Critical Care, Staten Island University Hospital, Staten Island, New York, USA.

Thoracostomy tubes are indicated for management of air or fluid in the pleural cavity. Pigtail catheters have emerged as an effective and less morbid alternative to traditional large bore chest tubes for evacuation of pleural air or fluid. However, they do not come without complications which commonly include pneumothorax and hemothorax. Read More

View Article
October 2018

Inhalation lung injury induced by smoke bombs in children: CT manifestations, dynamic evolution features and quantitative analysis.

J Thorac Dis 2018 Oct;10(10):5860-5869

Department of Radiology, Gansu Provincial Hospital, Lanzhou 713000, China.

Background: This retrospective study aimed to investigate the computed tomography (CT) manifestations, short-term dynamic evolution features and quantitative lung CT analysis of inhalation lung injury induced by smoke bomb flare.

Methods: Eleven pediatric patients (aged 11 to 13) who inhaled the smoke of smoke bombs underwent several low-dose chest CT scans. The image characteristics and their dynamic changes were observed and quantitative CT values were analyzed. Read More

View Article
October 2018

New Spirometry Indices for Detecting Mild Airflow Obstruction.

Sci Rep 2018 Nov 30;8(1):17484. Epub 2018 Nov 30.

Department of Electrical and Computer Engineering, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.

The diagnosis of chronic obstructive pulmonary disease (COPD) relies on demonstration of airflow obstruction. Traditional spirometric indices miss a number of subjects with respiratory symptoms or structural lung disease on imaging. We hypothesized that utilizing all data points on the expiratory spirometry curves to assess their shape will improve detection of mild airflow obstruction and structural lung disease. Read More

View Article
November 2018

Unusual Case of Plastic Bronchitis Presenting with Pneumopericardium.

Am J Case Rep 2018 Dec 3;19:1434-1436. Epub 2018 Dec 3.

Department of Internal Medicine, Wayne State University, Rochester Hills, MI, USA.

BACKGROUND Lymphatic circulation in the thorax enters the systemic blood flow at the subclavian vein. Instances where diversion occurs leads to complications such as pleural effusion. A rare complication of lymphatic diversion results in fluid accumulation in the bronchial tree, causing plastic bronchitis. Read More

View Article
December 2018

Dietary Nitrite Attenuates Elastase-Induced Pulmonary Emphysema in a Mouse Model.

Biol Pharm Bull 2018 ;41(12):1818-1823

Division of Pathophysiology, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University.

Pulmonary emphysema (PE) is a major pathological feature of chronic obstructive pulmonary disease (COPD) and is characterized by proteolytic destruction of the alveolar structure and subsequent inflammation of the respiratory tract. We hypothesized that nitrite attenuates the development of PE via anti-inflammatory actions. PE was induced by intratracheal instillation of porcine pancreas elastase (PPE) in mice. Read More

View Article
January 2018

Idiopathic Pulmonary Fibrosis: Epidemiology, Natural History, Phenotypes.

Med Sci (Basel) 2018 Nov 29;6(4). Epub 2018 Nov 29.

Instituto de Investigación, Hospital Universitario de la Princesa (IISP), Universidad Autónoma de Madrid, 28006 Madrid, Spain.

Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. It is characterized by a chronic, progressive, fibrotic interstitial lung disease of unknown cause that occurs primarily in older adults. Its prevalence and incidence have appeared to be increasing over the last decades. Read More

View Article
November 2018

B Cells Produce the Tissue-Protective Protein RELMα during Helminth Infection, which Inhibits IL-17 Expression and Limits Emphysema.

Cell Rep 2018 Dec;25(10):2775-2783.e3

Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ 07101, USA; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ 07101, USA. Electronic address:

Emphysema results in destruction of alveolar walls and enlargement of lung airspaces and has been shown to develop during helminth infections through IL-4R-independent mechanisms. We examined whether interleukin 17A (IL-17A) may instead modulate development of emphysematous pathology in mice infected with the helminth parasite Nippostrongylus brasiliensis. We found that transient elevations in IL-17A shortly after helminth infection triggered subsequent emphysema that destroyed alveolar structures. Read More

View Article
December 2018

The patient profile of individuals with Alpha-1 antitrypsine gene mutations at a referral center in Brazil.

J Bras Pneumol 2018 Sep-Oct;44(5):383-389

. Pulmonology Division, Instituto do Coração, Hospital das Clínicas, School of Medicine, Universidade de São Paulo, São Paulo (SP) Brazil.

Objective: The clinical, functional, radiological and genotypic descriptions of patients with an alpha-1 antitrypsin (A1AT) gene mutation in a referral center for COPD in Brazil.

Methods: A cross-sectional study of patients with an A1AT gene mutation compatible with deficiency. We evaluated the A1AT dosage and genotypic, demographic, clinical, tomographic, and functional characteristics of these patients. Read More

View Article
November 2017

Laparoscopic splenectomy: a new approach.

Clinics (Sao Paulo) 2018 Nov 29;73:e16536. Epub 2018 Nov 29.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Objectives: To introduce a new laparoscopic splenectomy (LS) approach.

Methods: Sixteen patients underwent LS with general anaesthesia and carbon dioxide pneumoperitoneum. The details of the surgery are as follows: 1. Read More

View Article
November 2018
3 Reads

Lobectomy with ECMO Support in an Infant Who Developed Pulmonary Interstitial Emphysema Following Repair of Hypoplastic Aortic Arch.

Braz J Cardiovasc Surg 2018 Sep-Oct;33(5):528-530

Department of Surgery; Division of Cardiothoracic Surgery; Pediatric and Congenital Cardiac Surgery Section Jackson Memorial Hospital - University of Miami Miller School of Medicine, Miami, USA.

Pulmonary interstitial emphysema (PIE) is a common problem in premature neonates with respiratory distress syndrome. This condition is often related to barotrauma caused by mechanical ventilation or continuous positive airway pressure applied to low birth weight neonates. The clinical diagnosis can be challenging. Read More

View Article
February 2018

Maxillofacial Fractures Associated With Laryngeal Injury: A Craniofacial Surgeon Should be Alert.

Ann Plast Surg 2018 Dec 3. Epub 2018 Dec 3.

From the Departments of Plastic and Reconstructive Surgery and.

Objective: Maxillofacial fractures with concomitant laryngeal injuries put both the quality and maintenance of life in jeopardy. Because of its low incidence, it is often overlooked in the clinical setting. The purpose of this study is to review the incidence, clinical presentations, managements, and outcomes of these patients. Read More

View Article
December 2018

A pathology not be overlooked in blunt chest trauma: Analysis of 181 patients with bilateral pneumothorax.

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):521-527

Department of Thoracic Surgery, Ege University Faculty of Medicine, İzmir-Turkey.

Background: Bilateral pneumothorax (BPTx) can become tension PTx and a cause of mortality, especially in severe multi-trauma patients. The purpose of this study was to analyze the incidence, morbidity, mortality, and associated factors of BPTx in multi-trauma patients in order to highlight the importance of the management of these cases, as well as complications, morbidity, and mortality.

Methods: The data of 181 patients with BPTx, from a total of 3782 trauma patients, were reviewed retrospectively. Read More

View Article
November 2018

Severe Cervicofacial Emphysema and Pneumomediastinum Caused by a Dental Handpiece: A Case Report and Guidelines for Management for the Dental Practitioner.

N Y State Dent J 2016 Nov;82(6):22-25

Cervicofacial emphysema (CE) is a rare but potentially serious condition that can arise iatrogenically from dental or surgical procedures. Dental handpieces with fore-exhaust can inject air into tissues at pressures at or greater than 30 psi. Since 1963, there have been approximately 100 case reports in the literature of iatrogenic CE from routine dental procedures. Read More

View Article
November 2016

Determining RBE for development of lung fibrosis induced by fractionated irradiation with carbon ions utilizing fibrosis index and high-LET BED model.

Clin Transl Radiat Oncol 2019 Jan 2;14:25-32. Epub 2018 Nov 2.

German Cancer Consortium (DKTK), Translational Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Background And Purposes: Carbon ion radiotherapy (CIRT) with raster scanning technology is a promising treatment for lung cancer and thoracic malignancies. Determining normal tissue tolerance of organs at risk is of utmost importance for the success of CIRT. Here we report the relative biological effectiveness (RBE) of CIRT as a function of dose and fractionation for development of pulmonary fibrosis using well established fibrosis index (FI) model. Read More

View Article
January 2019
1 Read

Lung function and CT lung densitometry in 37- to 39-year-old individuals with alpha-1-antitrypsin deficiency.

Int J Chron Obstruct Pulmon Dis 2018 8;13:3689-3698. Epub 2018 Nov 8.

Department of Respiratory Medicine and Allergology Malmö, Skåne University Hospital, Lund University, Malmö, Sweden,

Background: Alpha-1-antitrypsin (AAT) deficiency is a hereditary disorder that predisposes to emphysema. A cohort of severe (PiZZ) and moderate (PiSZ) AAT-deficient newborn infants was identified by the Swedish national neonatal AAT screening program in 1972-1974 and has been followed-up since birth. Our aim was to study whether the cohort has signs of emphysema in pulmonary function tests (PFTs) and computed tomography (CT) densitometry at 38 years of age in comparison with an age-matched control group, randomly selected from the population registry. Read More

View Article
November 2018

Basophils trigger emphysema development in a murine model of COPD through IL-4-mediated generation of MMP-12-producing macrophages.

Proc Natl Acad Sci U S A 2018 Dec 3. Epub 2018 Dec 3.

Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan;

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. It has generally been considered a non-Th2-type lung disorder, characterized by progressive airflow limitation with inflammation and emphysema, but its cellular and molecular mechanism remains ill defined, compared with that of asthma characterized by reversible airway obstruction. Here we show a previously unappreciated role for basophils at the initiation phase of emphysema formation in an elastase-induced murine model of COPD in that basophils represent less than 1% of lung-infiltrating cells. Read More

View Article
December 2018
1 Read

Decreased serum TRAIL is associated with increased mortality in smokers with comorbid emphysema and coronary artery disease.

Respir Med 2018 Dec 19;145:21-27. Epub 2018 Oct 19.

Emphysema COPD Research Center, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Background: Smokers are highly susceptible to lung and cardiovascular disease that can reduce their survival. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a protein in the circulation that may suppress vascular and pulmonary inflammation. Therefore, we hypothesized that diminished circulating TRAIL levels would be associated with poor survival in smokers with lung and cardiovascular disease. Read More

View Article
December 2018

Endoscopic repair of spontaneous esophageal rupture during gastroscopy: A CARE compliant case report.

Medicine (Baltimore) 2018 Nov;97(48):e13422

Department of Gastroenterology, The Fifth Affiliated Hospital of Wenzhou Medical University.

Rationale: Most of esophageal rupture is a very serious life-threatening benign gastrointestinal tract disease with high mortality. However, there are a few cases of spontaneous esophageal rupture during gastroscopy.

Patient Concerns: A 57-year-old man who underwent a routine diagnostic gastroscopy due to food obstruction was reported. Read More

View Article
November 2018

An aggregate score to stratify the technical complexity of video-assisted thoracoscopic lobectomy.

Interact Cardiovasc Thorac Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of Thoracic Surgery, The Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Objectives: The purpose of this study was to develop a score to predict the complexity of video-assisted thoracoscopic surgery (VATS) lobectomies preoperatively.

Methods: One hundred and thirty-nine consecutive patients undergoing VATS lobectomy operated on by a single surgeon as the first operator were included. Complex operations were defined as: operation time >180 min (corresponding to the 75th percentile) or a conversion to thoracotomy. Read More

View Article
November 2018

Autophagy augmentation alleviates cigarette smoke-induced CFTR-dysfunction, ceramide-accumulation and COPD-emphysema pathogenesis.

Free Radic Biol Med 2018 Nov 27. Epub 2018 Nov 27.

College of Medicine, Central Michigan University, Mt Pleasant, MI, USA; The Johns Hopkins University SOM University, Baltimore, MD, USA; VIJ Biotech LLC, Baltimore, MD, USA. Electronic address:

In this study, we aimed to investigate precise mechanism(s) of sphingolipid-imbalance and resulting ceramide-accumulation in COPD-emphysema. Where, human and murine emphysema lung tissues or human bronchial epithelial cells (Beas2b) were used for experimental analysis. We found that lungs of smokers and COPD-subjects with increasing emphysema severity demonstrate sphingolipid-imbalance, resulting in significant ceramide-accumulation and increased ceramide/sphingosine ratio, as compared to non-emphysema/non-smoker controls. Read More

View Article
November 2018

Occupational Exposure to Vapor, Gas, Dust, and Fumes, and Emphysema and Small Airways Disease: A New Role for Imaging with Computed Tomography.

Ann Am Thorac Soc 2018 Dec;15(12):1393-1394

1 Section of Occupational and Environmental Medicine and Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden.

View Article
December 2018

Case of Emphysema Uteri.

Authors:
Charles Mitchell

Lond Med Phys J 1831 May;10(59):391-392

Surgeon.

View Article

Cases of Emphysema, Depending upon Different Causes.

Authors:
P Meniere

Lond Med Phys J 1831 Oct;11(64):292-301

View Article
October 1831

Case of Emphysema, in Which the Stethoscope Afforded a Valuable Diagnosis.

Authors:
James Sym

Lond Med Phys J 1827 Jan;2(7):26-28

Surgeon, Kilmarnock, Ayrshire.

View Article
January 1827

Case of Fractured Ribs, Followed by Extensive Emphysema.

Authors:
Bell

Lond Med Phys J 1826 Sep;1(3):224-226

the Middlesex Hospital.

View Article
September 1826

Anatomical changes correlated with chronic pain in forensic medicine.

Authors:
Henry J Carson

Forensic Sci Res 2017 30;2(3):145-151. Epub 2017 Jun 30.

Linn County Medical Examiner's Office (retired), Cedar Rapids, IA, USA.

This study was performed to determine the relationships between chronic pain and anatomic changes that may occur in the body. Autopsies were performed on fatalities that required death investigation in Linn County, IA, or adjacent and nearby areas. Persons with chronic pain were older than the control population at the time of death. Read More

View Article
June 2017
2 Reads

A fatal case of oxygen embolism in a hospital.

Forensic Sci Res 2017 31;2(2):100-106. Epub 2017 May 31.

Unit of Forensic Imaging and Anthropology, University Center of Legal Medicine, CHUV Hospital, Lausanne-Geneva, Switzerland.

This case reports on a 68-year-old man who was found dead in hospital next to his bed. Before this, he had been treated with intravenous antibiotics for pneumonia. The body was found with a peripheral venous catheter connected to a nasal cannula delivering oxygen (O) from the wall. Read More

View Article

Endothelial Progenitor Cells and Notch-1 Signaling as Markers of Alveolar Endothelium Regeneration in Pulmonary Emphysema.

Bull Exp Biol Med 2018 Dec 28;166(2):201-206. Epub 2018 Nov 28.

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

We studied the effects of elastase, cigarette smoke extract, D-galactosamine hydrochloride, and tyrosine kinase inhibitor SU5416 on endothelial progenitor cells and angiogenesis precursors, as well as on Notch-1 expression by immature endothelial cells. Simultaneously with pulmonary emphysema, different damaging factors with diverse mechanisms of action caused pathological changes in the microvascular network of the lungs and destroyed the alveolar endothelium in female C57Bl/6 mice. D-galactosamine hydrochloride disturbed mobilization of endothelial progenitor cells expressing VEGFR (CD45-CD309) and angiogenesis progenitors (CD45CD309CD117) and their migration into emphysema expanded lungs. Read More

View Article
December 2018

Massive Subcutaneous Emphysema, Pneumoperitoneum, Pneumoretroperitoneum, and Pneumoscrotum following Endoscopic Retrograde Cholangiopancreatography in a Living Liver Donor.

Int J Organ Transplant Med 2018 1;9(3):132-135. Epub 2018 Aug 1.

Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, 244280, Malatya, Turkey.

Despite having many advantages, living donor liver transplantation has not been adopted by western countries due to risk of nearly life-threatening complications after living donor hepatectomy (LDH). Herein, we aimed at presenting the management of a 19-year-old patient who suffered life-threatening complications after right lobe LDH. A multiple detector computed tomography (MDCT) revealed a bilioma at the cut surface of the remnant liver, for which a transhepatic drainage catheter was placed. Read More

View Article

Competence in bronchoscopic treatments in emphysema.

Panminerva Med 2018 Nov 27. Epub 2018 Nov 27.

SOD Pneumologia Interventistica AOUC, Università degli Studi di Firenze, Florence, Italy.

Bronchoscopic lung volume reduction (BLVR) has been proven to be effective in patients with severe emphysema. These techniques are divided into two groups: non-blocking devices that are independent of collateral ventilation and blocking devices that are dependent on collateral ventilation so the choice of the target lobe with inadequate scissors is crucial for the success of the treatment. Current evidences suggest that not all classes and phenotypes of emphysema will benefit from BLVR, and that each technique appears to provide a greater benefit to specific subgroups of patients. Read More

View Article
November 2018

Necrotizing fasciitis of the thigh due to penetrated descending colon cancer: a case report.

Surg Case Rep 2018 Nov 26;4(1):136. Epub 2018 Nov 26.

Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.

Background: Necrotizing fasciitis (NF) caused by colorectal cancer is rare, and very few cases associated with colon cancer have been reported. We describe the case of a patient with NF in the left thigh due to penetration of descending colon cancer who was treated with one-stage surgical resection without creating a stoma.

Case Presentation: An 80-year-old woman was brought to our hospital complaining of fever and difficulty with body movement. Read More

View Article
November 2018
1 Read

Does Sericin, as a Novel Pleurodesis Agent, Have Higher Effectiveness Compared to Talcum Powder, Doxycycline, and Silver Nitrate Pleurodesis?

Arch Bronconeumol 2018 Nov 22. Epub 2018 Nov 22.

SBU, Turkiye Yuksek Ihtisas Training and Research Hospital, Thoracic Surgery and Lung Transplantation Clinic, Ankara, Turkey.

Introduction: The usefulness of sericin as pleurodesis agent has previously been described. Present study aims to compare sericin pleurodesis regarding success, effectiveness, tolerability, and side-effects.

Methods: Adult, 12-week-old Wistar-albino rats (n=60), divided to five groups as sericin, talcum-powder, doxycycline, silver-nitrate and control. Read More

View Article
November 2018
1 Read

Portuguese consensus document for the management of alpha-1-antitrypsin deficiency.

Pulmonology 2018 Dec;24 Suppl 1:1-21

Centro Hospitalar Lisboa Norte.

Alpha-1-antitrypsin deficiency (AATD) is a genetic autosomal codominant disorder caused by mutations in SERPINA1 gene. It is one of the most prevalent genetic disorders, although it remains underdiagnosed. Whereas at international level there are several areas of consensus on this disorder, in Portugal, inter-hospital heterogeneity in clinical practice and resources available have been adding difficulties in reaching a diagnosis and in making therapeutic decisions in this group of patients. Read More

View Article
December 2018
1 Read

Reduced area of the normal lung on high-resolution computed tomography predicts poor survival in patients with lung cancer and combined pulmonary fibrosis and emphysema.

Respir Investig 2018 Nov 21. Epub 2018 Nov 21.

Department of Respiratory Medicine, Respiratory Centre, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, Tokyo 105-8470, Japan; Okinaka Memorial Institute for Medical Research, 2-2-2 Toranomon Minato-ku, Tokyo 105-8470, Japan. Electronic address:

Background: This study aimed to determine the radiologic predictors and clarify the clinical features related to survival in patients with combined pulmonary fibrosis and emphysema (CPFE) and lung cancer.

Methods: We retrospectively reviewed the medical chart data and high-resolution computed tomography (HRCT) findings for 81 consecutive patients with CPFE and 92 primary lung cancers (70 men, 11 women; mean age, 70.9 years). Read More

View Article
November 2018
1 Read

Role of Stem Cells in the Pathogenesis of Chronic Obstructive Pulmonary Disease and Pulmonary Emphysema.

COPD 2018 Nov 23:1-21. Epub 2018 Nov 23.

a Dipartimento di Scienze Biomediche, Unità Operativa Complessa di Pneumologia , Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università degli Studi di Messina , Messina , Italy.

There are only few human translational studies performed in the area of stem cell research in patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary emphysema. Before progress to clinical trials with stem cells we strongly believe that more human translational studies are essential, otherwise, the clinical rationale would be solely based on limited in vitro and animal studies. In the future, stem cell therapy could be a treatment for this incurable disease. Read More

View Article
November 2018
2 Reads

Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozone-induced lung inflammation and emphysema.

Respir Res 2018 Nov 22;19(1):230. Epub 2018 Nov 22.

Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University, No.100, Haining Road, Shanghai, 200080, China.

Background: Mitochondrial damage leading to oxidant stress may play an important role in the pathogenesis of airflow obstruction and emphysema. NLPR3 inflammasome can be activated by mitochondrial ROS (mtROS) and other stimuli. We examined the importance of mtROS and NLRP3 inflammasome and their interactions in multiple ozone-induced lung inflammation and emphysema. Read More

View Article
November 2018
4 Reads

Endobronchial coil treatment in severe emphysema patients with alpha-1 antitrypsin deficiency.

Int J Chron Obstruct Pulmon Dis 2018 5;13:3645-3649. Epub 2018 Nov 5.

Service de Pneumologie, INSERM U1250, Hôpital Universitaire, Reims, France,

Endobronchial coil treatment (ECT) is a minimally invasive procedure developed for palliative care of patients with severe emphysema. ECT has demonstrated a decrease in hyperinflation, an improvement in quality of life, and an acceptable safety profile in randomized controlled trials (RCTs). Because alpha-1 antitrypsin deficiency (AATD) is a classical exclusion criterion in RCTs, there is no available data for ECT in AATD. Read More

View Article
November 2018
1 Read

Blood eosinophil count as a prognostic biomarker in COPD.

Int J Chron Obstruct Pulmon Dis 2018 31;13:3589-3596. Epub 2018 Oct 31.

Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, Korea,

Background: High blood eosinophil count is a predictive biomarker for response to inhaled corticosteroids in prevention of acute exacerbation of COPD, and low blood eosinophil count is associated with pneumonia risk in COPD patients taking inhaled corticosteroids. However, the prognostic role of blood eosinophil count remains underexplored. Therefore, we investigated the associated factors and mortality based on blood eosinophil count in COPD. Read More

View Article
October 2018
7 Reads

Influence of the type of emphysema in the relationship between COPD and lung cancer.

Int J Chron Obstruct Pulmon Dis 2018 29;13:3563-3570. Epub 2018 Oct 29.

Pneumology Department, Álvaro Cunqueiro Hospital, Sanitary Area of Vigo, NeumovigoI+i Investigation Group, Health Research Institute Galicia Sur (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain,

Introduction: There are no studies analyzing the relationship between emphysema and lung cancer (LC). With this aim and in order to make some comparisons between different clinical variables, we carried out the present study.

Methods: This is a case-control study, patients with COPD and LC being the cases and subjects with stable COPD being the controls. Read More

View Article
October 2018
3 Reads

Inflammation and Endothelial Activation in Early Adulthood are Associated with Future Emphysema: The CARDIA Lung Study.

Eur Respir J 2018 Nov 21. Epub 2018 Nov 21.

Asthma and COPD Program, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

View Article
November 2018
4 Reads

Purse-string sutures using novel endoloops and repositionable clips for the closure of large iatrogenic duodenal perforations with single-channel endoscope: a multicenter study.

Surg Endosc 2018 Nov 20. Epub 2018 Nov 20.

Digestive Endoscopy Department, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.

Background: Serious complications due to perforation restrict the development of duodenal endoscopic treatment. The key stage for remediation is the successful endoscopic closure to prevent peritonitis and the need for surgical intervention. This report aimed to present a new simple method for the closure of large iatrogenic duodenal perforations with purse-string sutures using the novel endoloops and repositionable clips through a single-channel endoscope. Read More

View Article
November 2018
6 Reads

Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD.

Sci Rep 2018 Nov 20;8(1):17132. Epub 2018 Nov 20.

Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States of America.

Chronic obstructive pulmonary disease (COPD) comprises multiple phenotypes such as airflow obstruction, emphysema, and frequent episodes of acute worsening of respiratory symptoms, known as exacerbations. The goal of this pilot study was to test the usefulness of unbiased metabolomics and transcriptomics approaches to delineate biological pathways associated with COPD phenotypes and outcomes. Blood was collected from 149 current or former smokers with or without COPD and separated into peripheral blood mononuclear cells (PBMC) and plasma. Read More

View Article
November 2018
2 Reads

Pneumomediastinum and Subcutaneous Emphysema after Flexible Bronchoscopy.

Arch Bronconeumol 2018 Nov 17. Epub 2018 Nov 17.

Departamento de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España. Electronic address:

View Article
November 2018
2 Reads

Long-Term Results Following Lung Volume Reduction Surgery: A Single Institution's Experience.

Ann Thorac Surg 2018 Nov 17. Epub 2018 Nov 17.

The Ohio State University Wexner Medical Center.

Background: The National Emphysema Treatment Trial (NETT) showed a clear survival and quality of life benefit for patients selected for lung volume reduction surgery (LVRS). However, long-term outcomes following LVRS are still lacking. The aim of this study is to evaluate overall mortality and functional durability in this single institutional cohort of patients undergoing LVRS. Read More

View Article
November 2018
5 Reads