200,245 results match your criteria Emerging infectious diseases[Journal]


Cardiovascular and Metabolic Risk in Women in the First Year Postpartum: Allostatic Load as a Function of Race, Ethnicity, and Poverty Status.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Internal Medicine, UCLA Geffen School of Medicine, Los Angeles, California.

Objective:  Allostatic load (AL) represents multisystem physiological "wear-and-tear" reflecting emerging chronic disease risk. We assessed AL during the first year postpartum in a diverse community sample with known health disparities.

Methods:  The Shriver National Institute for Child Health and Human Development Community Child Health Network enrolled 2,448 predominantly low-income African-American, Latina, and White women immediately after delivery of liveborn infants at ≥20 weeks' gestation, following them over time with interviews, clinical measures, and biomarkers. Read More

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December 2018

MiR-23a-3p acts as an oncogene and potential prognostic biomarker by targeting PNRC2 in RCC.

Biomed Pharmacother 2018 Dec 11;110:656-666. Epub 2018 Dec 11.

Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China. Electronic address:

Background: Renal cell carcinoma (RCC) is a most common kidney malignancy, with atypical symptoms in the early stage and poor outcome in the late stage. Recently, emerging evidence revealed that some miRNAs play an essential role in the tumorigenesis and progression of RCC. Therefore, the aim of this study is that understand the detailed molecular mechanism of miR-23a-3p in RCC and identify its potential clinical value. Read More

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December 2018

Transport of platinum-based pharmaceuticals in water-saturated sand and natural soil: Carboplatin and cisplatin species.

Chemosphere 2018 Dec 4;219:390-399. Epub 2018 Dec 4.

Department of Earth and Planetary Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.

This study reports the transport characteristics of the pharmaceutical compounds carboplatin and cisplatin, and their respective derivatives, in saturated sand and soil columns. Pharmaceuticals are recognized as emerging pollutants of soil and water resources, but studies of the transport characteristics of organometallic pharmaceuticals in soil-water environments are rare. A recent study of oxaliplatin transport in natural soil raises the question of whether or not its behavior is representative of all Pt-based pharmaceuticals behavior in soil-water systems. Read More

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December 2018

CircRNAs and cancer: biomarkers and master regulators.

Semin Cancer Biol 2018 Dec 11. Epub 2018 Dec 11.

Molecular Oncology group, Biodonostia Research Institute, Paseo Doctor Begiristain, s/n San Sebastián, 20014, Spain; Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom; IKERBASQUE, Basque Foundation for Science, María Díaz Haroko Kalea, 3, 48013, Bilbao, Spain. Electronic address:

Circular RNAs (circRNAs) are a novel class of regulatory RNAs that despite being relatively abundant have only recently begun to be explored. There are many thousands of genes that appear capable of producing circRNAs, however the function of all but a handful remain to be determined. What is emerging about these highly conserved molecules is that they play important roles in biology and cancer biology in particular. Read More

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December 2018

Etiology and epidemiology of community-acquired pneumonia in adults requiring hospital admission: a prospective study in rural Central Philippines.

Int J Infect Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Virology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Japan980-8575; Collaborating Research Center for Emerging and Reemerging Infectious Diseases, 9002 Research Drive, Filinvest Corporate City, Alabang, Muntinlupa City, Metro Manila, Philippines 1781.

Background: Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality among adults worldwide. However, the distribution of etiology of CAP varies from one country to another with limited data from rural areas.

Methods: A prospective hospital-based study on adult CAP was conducted in Leyte, Central Philippines from May 2010 to May 2012. Read More

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December 2018

Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets.

Antiviral Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Filoviruses, which include Ebola virus and Marburg virus, are negative-sense RNA viruses associated with sporadic outbreaks of severe viral hemorrhagic fever characterized by uncontrolled virus replication. The extreme virulence and emerging nature of these zoonotic pathogens make them a significant threat to human health. Replication of the filovirus genome and production of viral RNAs requires the function of a complex of four viral proteins, the nucleoprotein (NP), viral protein 35 (VP35), viral protein 30 (VP30) and large protein (L). Read More

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December 2018

West Nile virus epizootic in Germany, 2018.

Antiviral Res 2018 Dec 11. Epub 2018 Dec 11.

Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, Germany; German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel, Greifswald-Insel Riems, Germany. Electronic address:

The summer of 2018 in Germany was the second hottest and driest on record. These generally extremely favorable climatic conditions most likely triggered the further expansion and the efficient propagation of the zoonotic arthropod-borne West Nile virus in many Southern/Southeastern and even Central European countries. WNV infections were detected for the first time in resident wild and aviary birds, such as common blackbirds, northern goshawks and great grey owls in Eastern and Southeastern Germany. Read More

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December 2018

Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

Cell 2018 Dec;175(7):1931-1945.e18

Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA; The J. David Gladstone Institutes, San Francisco, CA, USA. Electronic address:

Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a growing public health concern. Systems-level analysis of how flaviviruses hijack cellular processes through virus-host protein-protein interactions (PPIs) provides information about their replication and pathogenic mechanisms. We used affinity purification-mass spectrometry (AP-MS) to compare flavivirus-host interactions for two viruses (DENV and ZIKV) in two hosts (human and mosquito). Read More

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December 2018

Temperature-driven changes in viral loads in the honey bee Apis mellifera.

J Invertebr Pathol 2018 Dec 11. Epub 2018 Dec 11.

INRA, UR 406 Abeilles et Environnement - Site Agroparc - Domaine St Paul - 228, Route de l'aérodrome CS40509 - 84914 Avignon Cedex 9, France.

Many of the physiological traits in insects are shaped by environmental temperatures, which can influence their interactions with pathogens. Therefore, quantifying the thermal responses of the host-pathogen system is crucial for better understanding and predicting their dynamics due to environmental changes. This is particularly important in honey bees, which are experiencing severe colony losses around the world, notably due to infection with the Deformed wing virus (DWV). Read More

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December 2018

Detection of Malignancy-Associated Phosphoproteome Changes in Human Colorectal Cancer Induced by Cell Surface Binding of Growth-Inhibitory Galectin-4.

IUBMB Life 2018 Dec 14. Epub 2018 Dec 14.

Department of Applied Tumor Biology, Institute of Pathology, Medical School of the Ruprecht-Karls-University, Heidelberg, Germany.

Emerging evidence on efficient tumor growth regulation by endogenous lectins directs interest to determine on a proof-of-principle level the range of information on alterations provided by full-scale analysis using phosphoproteomics. In our pilot study, we tested galectin-4 (gal-4) that is a growth inhibitor for colon cancer cells (CRC), here working with the LS 180 line. In order to cover monitoring of short- and long-term effects stable isotope labeling by amino acids in cell culture-based quantitative phosphoproteomic analyses were conducted on LS 180 cell preparations collected 1 and 72 h after adding gal-4 to the culture medium. Read More

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December 2018

Translating preventive chemotherapy prevalence thresholds for Schistosoma mansoni from the Kato-Katz technique into the point-of-care circulating cathodic antigen diagnostic test.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006941. Epub 2018 Dec 14.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: Intervention guidelines against Schistosoma mansoni are based on the Kato-Katz technique. However, Kato-Katz thick smears show low sensitivity, especially for light-intensity infections. The point-of-care circulating cathodic antigen (POC-CCA) is a promising rapid diagnostic test detecting antigen output of living worms in urine and results are reported as trace, 1+, 2+, and 3+. Read More

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December 2018
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Using a coupled dynamic factor - random forest analysis (DFRFA) to reveal drivers of spatiotemporal heterogeneity in the semi-arid regions of southern Africa.

PLoS One 2018 14;13(12):e0208400. Epub 2018 Dec 14.

Department of Environmental Engineering Sciences, University of Florida, Gainesville, Florida, United States of America.

Understanding the drivers of large-scale vegetation change is critical to managing landscapes and key to predicting how projected climate and land use changes will affect regional vegetation patterns. This study aimed to improve our understanding of the role, magnitude, and spatial distribution of the key environmental and socioeconomic factors driving vegetation change in a southern African savanna. This research was conducted across the Kwando, Okavango and Zambezi catchments of southern Africa (Angola, Namibia, Botswana and Zambia) and explored vegetation cover change across the region from 2001-2010. Read More

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December 2018

Individual and sexual network predictors of HIV incidence among men who have sex with men in Nigeria.

J Acquir Immune Defic Syndr 2018 Dec 10. Epub 2018 Dec 10.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: To date, HIV incidence studies among men who have sex with men (MSM) across sub-Saharan Africa have focused on studying sexual risk practices with less focus on sexual networks.

Setting: TRUST/RV368 conducted in Abuja and Lagos, Nigeria recruited MSM using respondent driven sampling (RDS) and followed HIV negative men for incident infection over 4 years.

Methods: Four-hundred forty-one HIV-uninfected MSM underwent a parallel rapid HIV testing algorithm every 3 months for up to 18 months. Read More

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December 2018

Emerging immunotherapies for autoimmune kidney disease.

Hum Vaccin Immunother 2018 Dec 14. Epub 2018 Dec 14.

a Department of Medicine , Duke University Medical Center , Durham , NC , USA.

Autoimmunity is a leading cause of chronic kidney disease and loss of native and transplanted kidneys. Conventional immunosuppressive therapies can be effective but are non-specific, noncurative, and risk serious side effects such as life-threatening infection and cancer. Novel therapies and targeted interventions are urgently needed. Read More

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December 2018

Is developmental change in gender-typed behavior associated with adult sexual orientation?

Dev Psychol 2018 Dec 13. Epub 2018 Dec 13.

Carolina Population Center, Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill.

The goal of this article was to examine gender-typed behavior longitudinally and to consider its relationship with sexual orientation in adulthood. Data were from 10,624 respondents who completed Wave 1 (adolescence), Wave 3 (emerging adulthood), and Wave 4 (early adulthood) of the National Longitudinal Study of Adolescent to Adult Health. First, we described the distributions of gender-typed behavior by adult sexual orientation at each of the three developmental stages. Read More

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December 2018
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Typologies of discrimination: Latinx youth's experiences in an emerging immigrant community.

Dev Psychol 2018 Dec 13. Epub 2018 Dec 13.

School of Education, University of North Carolina at Greensboro.

Few studies examine how racial-ethnic peer discrimination experiences of Latinx youth vary across the race-ethnicity of the perpetrator. In a sample of 170 Latinx early adolescents (M = 12.86 years, range = 10. Read More

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December 2018

Depressive symptoms in Latina mothers in an emerging immigrant community.

Cultur Divers Ethnic Minor Psychol 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology, University of North Carolina at Greensboro.

Objectives: Latina mothers in emerging immigrant communities experience heightened risk for depressive symptoms because of the convergence of multiple risk factors rooted in economic, cultural, and familial experiences. Previous research with Latina/o adolescents has found that discrimination, and not acculturative stress, predicts depressive symptoms; however, no research to our knowledge has examined the relative impact of both discrimination and acculturative stress in Latina mothers.

Method: The present study expands this literature by examining how both universal (i. Read More

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December 2018

Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks.

Chem Rev 2018 Dec 14. Epub 2018 Dec 14.

University of California , San Diego, 9500 Gilman Drive, BRFII , La Jolla , CA 92093-0702 , United States.

Cellular signaling networks are the foundation which determines the fate and function of cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over 25 years ago enabled the development of a diverse array of genetically encodable fluorescent biosensors that are capable of measuring the spatiotemporal dynamics of signal transduction pathways in live cells. In an effort to encapsulate the breadth over which fluorescent biosensors have expanded, we endeavored to assemble a comprehensive list of published engineered biosensors, and we discuss many of the molecular designs utilized in their development. Read More

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December 2018

[Biological risk in agriculture and construction workplaces: a survey on perception, knowledge and prevention measures.]

G Ital Med Lav Ergon 2018 Dec;40(4):195-202

Cattedra di Igiene, Dipartimento di Medicina e Scienze per la Salute "Vincenzo Tiberio", Università degli Studi del Molise.

Objectives: Despite the potential presence in many workplaces, biological risk is little known and largely underestimated, except in healthcare environments. Objectives: To evaluate perception, knowledge and behaviors adopted for protection and prevention of biological risk, related also to the occupational activity, among construction and agricultural workers.

Methods: Workers were recruited at farms and construction companies of Molise Region, Central Italy, which were visited within the surveillance activities planned by local institutions. Read More

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December 2018

[Social determinants of the health of international migrant children in Chile: qualitative evidence.]

Salud Publica Mex 2018 Sep-Oct;60(5):566-578

Programa de Estudios Sociales en Salud, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo. Santiago, Chile.

Objective: To explore the social determinants of health (SDH) of international migrant children, from the perceptions of caregivers, health workers and local authorities in eight municipalities in Chile.

Materials And Methods: A secondary analysis of data was conducted from a qualitative study that took place between 2014 and 2017. The original study involved semi-structured interviews and focus groups. Read More

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Sparsity-based photoacoustic image reconstruction with a linear array transducer and direct measurement of the forward model.

J Biomed Opt 2018 Dec;24(3):1-9

Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire, United States.

Photoacoustic (PA) imaging is an emerging imaging technique for many clinical applications. One of the challenges posed by clinical translation is that imaging systems often rely on a finite-aperture transducer rather than a full tomography system. This results in imaging artifacts arising from an underdetermined reconstruction of the initial pressure distribution (IPD). Read More

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December 2018

[Efficacy of SUPRA HFR in the treatment of acute renal damage during multiple myeloma].

G Ital Nefrol 2018 Dec;35(6)

S.C. Nefrologia, Dialisi e Trapianto U. AOU Città della Salute e della Scienza di Torino, Torino, Italia.

Acute Kidney Injury (AKI) is a frequent complication of multiple myeloma (MM) with unfavorable prognostic significance. Light chains removal, combined with hematological therapy (CT) seems to offer significant benefits to renal function recovery (RFR). The SUPRA HFR, through the combination of high cut-off membrane without albumin loss and adsorbent cartridge, represents one of the "emerging" light chain removal methods. Read More

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December 2018

[Knee osteotomies : a renaissance ?]

Rev Med Suisse 2018 Dec;14(631):2254-2258

Service d'orthopédie et de traumatologie de l'appareil locomoteur, Chirurgie du genou, Département de l'appareil locomoteur, CHUV, 1011 Lausanne.

There is a regain of interest for knee osteotomies over the last decade. A better knowledge of their long-term benefits and potential adverse events has increased their importance in the treatment of unicompartmental osteoarthritis. Emerging indications result from increasing evidence that the control of knee alignment is crucial in knee instability, meniscal transplantation and cartilage repair. Read More

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December 2018

Long Non-Coding RNA TUG1 as a Potential Novel Biomarker for Predicting the Clinical Outcome of Cancer Patients: a Meta-Analysis.

Clin Lab 2018 Oct;64(11)

Background: Emerging evidence suggests that long non-coding RNAs (lncRNAs) can be used as potential biomarkers for a wide range of cancers. Herein, the prognostic value of lncRNA taurine upregulated gene (TUG1) was analyzed using meta-analysis in different kinds of cancers. Methods: Databases including Cochrane Library, PubMed, and Chinese National Knowledge Infrastructure were searched for epidemiological studies up to March 2018. Read More

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October 2018

Hybrid ablation under intraoperative 3D voltage mapping guidance.

Multimed Man Cardiothorac Surg 2018 Dec 10;2018. Epub 2018 Dec 10.

Long-standing persistent atrial fibrillation remains a significant therapeutic challenge, often proving to be resistant to treatment with antiarrhythmic medications and transcatheter ablation. Hybrid ablation, which combines a minimally invasive surgical and transcatheter approach, is emerging as a promising treatment option. In this video tutorial, we demonstrate our method of hybrid ablation for long-standing persistent atrial fibrillation using advanced 3D electro-anatomical voltage mapping to guide the ablation process and thereby improve the ultimate effectiveness of the procedure. Read More

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December 2018

Understanding assessment on a hospital ward for older people: a qualitative study.

J Adv Nurs 2018 Dec 14. Epub 2018 Dec 14.

Warwick Research in Nursing, University of Warwick and Oxford Trauma, Kadoorie Centre, NDORMS, University of Oxford and Oxford University Hospitals NHS Trust.

Aim: To explore assessment on a hospital ward for older people from the perspectives of patients and healthcare professionals.

Design: A qualitative study drawing on grounded theory was undertaken between February 2015 - January 2016.

Methods: Interviews with 15 patients and 22 healthcare professionals, a focus group with six healthcare professionals, 45 hours of observation and review of 18 sets of patient notes. Read More

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December 2018

The serine protease testisin is present on the surface of capacitated stallion spermatozoa and interacts with key zona pellucida binding proteins.

Andrology 2018 Dec 13. Epub 2018 Dec 13.

Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.

Background And Objectives: Serine proteases are emerging as important players in the spermatozoon's acquisition of functional competence. This study aimed to characterize the serine protease testisin (PRSS21) in stallion spermatozoa, examining its surface expression, possible origins in the testis and epididymis, and changes in response to capacitation and acrosome reaction, as well as its capacity to form high molecular weight complexes and interact with other proteins.

Materials And Methods: The role of serine proteases in spontaneous capacitation and acrosome reaction of stallion spermatozoa was established using the serine protease inhibitor, AEBSF. Read More

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December 2018

Toward zonally tailored scaffolds for osteochondral differentiation of synovial mesenchymal stem cells.

J Biomed Mater Res B Appl Biomater 2018 Dec 13. Epub 2018 Dec 13.

Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York.

Synovium-derived mesenchymal stem cells (SMSCs) are an emerging cell source for regenerative medicine applications, including osteochondral defect (OCD) repair. However, in contrast to bone marrow MSCs, scaffold compositions which promote SMSC chondrogenesis/osteogenesis are still being identified. In the present manuscript, we examine poly(ethylene) glycol (PEG)-based scaffolds containing zonally-specific biochemical cues to guide SMSC osteochondral differentiation. Read More

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December 2018

A comparison of the EU regulatory approach to directed mutagenesis with that of other jurisdictions, consequences for international trade and potential steps forward.

New Phytol 2018 Dec 13. Epub 2018 Dec 13.

Biotechnology Directorate, Ministry of AgroIndustry, Buenos Aires, Argentina; National University of Quilmes, Bernal, Argentina.

A special regulatory regime applies to products of recombinant nucleic acid modifications. A ruling from the European Court of Justice has interpreted this regulatory regime in a way that it also applies to emerging mutagenesis techniques. Elsewhere regulatory progress is also ongoing. Read More

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December 2018

Romantic Conflict Narratives in Emerging Adult Couples: Viewpoint and Gender Matter.

Fam Process 2018 Dec 13. Epub 2018 Dec 13.

Merrill Palmer Skillman Institute, Wayne State University, Detroit, MI.

Healthy romantic relationships entail understanding the needs of the self and other when interpreting conflict events. Yet how couples make meaning around specific conflicts and their capacity to reflect on their own and their partners' unmet needs is understudied. Using narratives, we examined destructive (e. Read More

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December 2018

Regional Pungency Degree in China and Its Correlation with Typical Climate Factors.

J Food Sci 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Environment Correlative Dietology, Ministry of Education, China.

Chili is an indispensable condiment in Chinese dishes. Due to regional environmental and cultural differences, there are certain differences in the regional food spicy degree. This study analyzed the pungency degree of dishes in 21 regions of China and created a pungency degree map using experiments and statistics. Read More

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December 2018

Global patterns in excess body weight and the associated cancer burden.

CA Cancer J Clin 2018 Dec 12. Epub 2018 Dec 12.

Scientific Vice President, Surveillance and Health Services Research, American Cancer Society, Atlanta, GA.

The prevalence of excess body weight and the associated cancer burden have been rising over the past several decades globally. Between 1975 and 2016, the prevalence of excess body weight in adults-defined as a body mass index (BMI) ≥ 25 kg/m -increased from nearly 21% in men and 24% in women to approximately 40% in both sexes. Notably, the prevalence of obesity (BMI ≥ 30 kg/m ) quadrupled in men, from 3% to 12%, and more than doubled in women, from 7% to 16%. Read More

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December 2018

The insights into molecular pathways of hypoxia-inducible factor in the brain.

J Neurosci Res 2018 Dec 12. Epub 2018 Dec 12.

Departments of Anesthesiology and Physiology, School of Medicine, Loma Linda University, Loma Linda, California.

The objectives of this present work were to review recent developments on the role of hypoxia-inducible factor (HIF) in the survival of cells under normoxic versus hypoxic and inflammatory brain conditions. The dual nature of HIF effects appears well established, based on the accumulated evidence of HIF playing both the role of adaptive factor and mediator of cell demise. Cellular HIF responses depend on pathophysiological conditions, developmental phase, comorbidities, and administered medications. Read More

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December 2018
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A Triazolotriazine-based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition.

ChemMedChem 2018 Dec 12. Epub 2018 Dec 12.

University of Trieste, Department of Chemical and Pharmaceutical Sciences, Via Licio Giorgeri 1, 34127, Trieste, ITALY.

GSK-3β and CK-1δ are emerging targets for the treatment of neuroinflammatory disorders, including Parkinson's disease. An inhibitor able to target these two kinases was developed by docking-based design.. Read More

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December 2018

Programmed death ligand-1 is associated with tumor infiltrating lymphocytes and poorer survival in urothelial cell carcinoma of the bladder.

Cancer Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, China.

Drugs blocking programmed death ligand-1 (PD-L1) have shown unprecedented activity in metastatic and unresectable bladder cancer. The purpose of the present study was to investigate the expression, clinical significance and association of PD-L1 with tumor-infiltrating lymphocytes (TIL) in resectable urothelial cell carcinoma of the bladder (UCB). In this retrospective study, 248 UCB patients who received radical cystectomy or transurethral resection were examined. Read More

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December 2018

Patient and public involvement in medical performance processes: A systematic review.

Health Expect 2018 Dec 11. Epub 2018 Dec 11.

Collaboration for the Advancement of Medical Education Research and Assessment, Faculty of Medicine and Dentistry, University of Plymouth, Plymouth, UK.

Background: Patient and public involvement (PPI) continues to develop as a central policy agenda in health care. The patient voice is seen as relevant, informative and can drive service improvement. However, critical exploration of PPI's role within monitoring and informing medical performance processes remains limited. Read More

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December 2018

Hollow Metal-Organic-Framework Micro/Nanostructures and their Derivatives: Emerging Multifunctional Materials.

Adv Mater 2018 Dec 12:e1803291. Epub 2018 Dec 12.

Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Chinese Academy of Sciences, No. 11, Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China.

Hollow metal-organic framework (MOF) micro/nanostructures and their derivatives are attracting a great amount of research interest in recent years because their hierarchical porous structures not only provide abundant, easily accessed metal sites but also endow 3D channels for rapid mass transport. As a result, they demonstrate significant advantages in many applications including catalysis, gas sensors, batteries, supercapacitors, and so on. Nevertheless, studies on hollow MOFs and their derivatives are still at the beginning of this field, and the relationship between their structures and application performances is not yet reviewed comprehensively. Read More

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December 2018

Neuroinflammation in the central nervous system: Symphony of glial cells.

Glia 2018 Dec 11. Epub 2018 Dec 11.

Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.

Neuroinflammation in the central nervous system (CNS) is an important subject of neuroimmunological research. Emerging evidence suggests that neuroinflammation is a key player in various neurological disorders, including neurodegenerative diseases and CNS injury. Neuroinflammation is a complex and well-orchestrated process by various groups of glial cells in CNS and peripheral immune cells. Read More

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December 2018

Pathological prognostication of paediatric adrenocortical tumours: Is a gold standard emerging?

Pediatr Blood Cancer 2018 Dec 11:e27567. Epub 2018 Dec 11.

Department of Paediatric Surgery, The Children's Hospital at Westmead, Sydney, Australia.

Background: Criteria for the pathological classification of adult adrenocortical tumours (ACTs) have been found to overestimate the malignant potential of childhood ACTs. We sought to evaluate the accuracy and utility of criteria developed for paediatric ACT compared to current criteria for adults.

Methods: ACTs treated between January 2006 and December 2016 in two paediatric institutions were evaluated. Read More

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December 2018

Apelinergic system in the kidney: implications for diabetic kidney disease.

Physiol Rep 2018 Dec;6(23):e13939

Department of Medicine, Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

The bioactive peptides of the apelinergic system and its receptor APJ have been shown to play a protective role in experimental cardiovascular and diabetic kidney disease (DKD). Mechanisms of this renoprotective effect remain to be elucidated. In this study, we examined the localization of APJ within the normal kidney and its kidney expression in the db/db model of DKD. Read More

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December 2018

Concurrent chemoradiotherapy by simultaneously integrated boost volumetric-modulated arc therapy for nasopharyngeal carcinoma-toxicity/quality of life and survival.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Department of Cosmetics and Fashion Styling, Center of Environmental Roxi and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung, Taiwan.

Background: To investigate the toxicity, changes of quality of life (QOL), and survival for patients with nasopharyngeal cancer (NPC) treated by concurrent chemoradiotherapy (CCRT) with simultaneously integrated boost volumetric-modulated arc therapy (SIB-VMAT).

Methods: A total of 68 NPC patients treated by CCRT with SIB-VMAT technique were collected. QOL was longitudinally assessed by the EORTC QLQ-C30 and HN35 questionnaires at the 4 time points: baseline, 42. Read More

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December 2018

Chikungunya Virus: History, Geographic Distribution, Clinical Picture, and Treatment.

P R Health Sci J 2018 Dec;37(4):187-194

Third-year medical student, University of Puerto Rico Medical Sciences Campus, San Juan, PR.

Chikungunya fever (CHIKF) is a re-emerging mosquito-borne disease caused by a virus endemic to Africa and Asia. Due to the ease with which its vectors propagate, the virus has spread to India and Europe, and more recently it arrived to the Caribbean, eventually extending into North, Central, and South America. According to the World Health Organization (WHO), the most common clinical manifestations are abrupt fever, polyarthralgia, headache, maculopapular rash, myalgia, and nausea/vomiting. Read More

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December 2018

LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway.

J Exp Clin Cancer Res 2018 Dec 14;37(1):316. Epub 2018 Dec 14.

College of Laboratory Medicine, Dalian Medical University, 9 Lushunnan Road Xiduan, Dalian, 116044, Liaoning Province, China.

Background: Long non-coding RNAs (LncRNAs) emerging as pivotal marker in the procession of cancer, including colorectal cancer (CRC). Abnormal O-glycosylation is a crucial modification during cancer malignancy. The aim of this work is to analyze the alteration of O-glycosylation involved in CRC progression. Read More

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December 2018

Pathogenicity and molecular characterization of a fowl adenovirus 4 isolated from chicken associated with IBH and HPS in China.

BMC Vet Res 2018 Dec 14;14(1):400. Epub 2018 Dec 14.

College of Veterinary Medicine, Hebei Agricultural University, Baoding, 071001, Hebei, China.

Background: Since July in 2015, an emerging infectious disease, Fowl adenovirus (FAdV) species C infection with Hepatitis-Hydropericardium syndrome was prevalent in chicken flocks in China. In our study, one FAdV strain was isolated from commercial broiler chickens and was designated as SDSX1.The phylogenetic information, genetic mutations and pathogenicity of SDSX1 were evaluated. Read More

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December 2018

Dietary nutrient allocation to somatic tissue synthesis in emerging subimago freshwater mayfly Ephemera danica.

BMC Ecol 2018 Dec 14;18(1):57. Epub 2018 Dec 14.

Limnological Institute, University of Konstanz, Mainaustrasse 252, 78464, Constance, Germany.

Background: The relative importance of nutrients derived from different sources for tissue synthesis is crucial for predicting a species responds to changes in food availability. The ecological and physiological strategies that govern the incorporation and routing of nutrients for reproduction are often well understood. However, the role and adaptive value of both species and individual variation during early life-stage remain elusive. Read More

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December 2018

Exploring mental health practice among Traditional health practitioners: a qualitative study in rural Kenya.

BMC Complement Altern Med 2018 Dec 14;18(1):334. Epub 2018 Dec 14.

Africa Mental Health Foundation and Department of Psychiatry, University of Nairobi, Mawensi Road, Off Elgon road, Mawensi Garden, P.O. BOX 48423-00100, Nairobi, Kenya.

Background: Involvement of traditional health practitioners (THPs) in the form of collaboration with the formal health care system is suggested to improve the pathways to mental health care in Kenya, yet understanding of the current traditional practice and THPs' perspectives is lacking. The aim of this study was to explore the views of THPs with respect to their mental health practice.

Methods: This study qualitatively explored the views of THPs, using four focus group discussions (FDGs) each consisting of 8-10 traditional and faith healers, resulting in a total of 36 participants. Read More

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December 2018

The emerging role of microRNA-4487/6845-3p in Alzheimer's disease pathologies is induced by Aβ25-35 triggered in SH-SY5Y cell.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):119. Epub 2018 Dec 14.

Department of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.

Background: Accumulation of amyloid β-peptide (Aβ) is implicated in the pathogenesis and development of Alzheimer's disease (AD). Neuron-enriched miRNA was aberrantly regulated and may be associated with the pathogenesis of AD. However, regarding whether miRNA is involved in the accumulation of Aβ in AD, the underlying molecule mechanism remains unclear. Read More

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December 2018

Brucellosis in the Addis Ababa dairy cattle: the myths and the realities.

BMC Vet Res 2018 Dec 14;14(1):396. Epub 2018 Dec 14.

Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.

Background: Bovine brucellosis is considered as an important disease among livestock and people in sub-Saharan African countries including Ethiopia. A cross-sectional study was conducted from November 2016 to May 2017 to estimate the prevalence and associated risk factors, and to assess knowledge-attitude and practices (KAP) of farm workers about bovine brucellosis in Addis Ababa dairy farms.

Results: A total of 1550 cattle from 127 dairy farms were serially tested using the Rose Bengal Plate Test (RBPT), Competitive Enzyme-Linked Immunosorbant Assay (c-ELISA) and Complement Fixation Test (CFT). Read More

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December 2018