199,721 results match your criteria Emerging health threats journal[Journal]


[The Rezūm system in the treatment of male lower urinary tract symptoms (LUTSs) due to benign prostatic obstruction (BPO)].

Aktuelle Urol 2018 Dec 6;49(6):519-524. Epub 2018 Dec 6.

Spital Thurgau AG, Urologie, Frauenfeld.

The classical algorithm of the management of male lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH) includes a surgical approach in case pharmacological therapy has failed. Emerging minimally-invasive treatments (MITs) offer potential for rapid symptomatic relief, reducing the morbidity of invasive BPH surgery. Convective interstitial radiofrequency water vapour thermal ablation of the prostate with the Rezūm system is a novel MIT for the treatment of bothersome moderate-to-severe lower urinary tract symptoms associated with BPH. Read More

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December 2018
8 Reads

Neuropathic Pain.

Semin Neurol 2018 Dec 6;38(6):644-653. Epub 2018 Dec 6.

Department of Neurology, Boston University, Boston, Massachusetts.

Neuropathic pain management is challenging, and typically requires a multifaceted approach. There are several treatment options, both pharmacologic and nonpharmacologic. Of the available pharmacologic agents, those with the strongest supporting evidence include tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, and certain antiseizure agents. Read More

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December 2018
2 Reads

Microbial Intervention as a Novel Target in Treatment of Non-Alcoholic Fatty Liver Disease Progression.

Cell Physiol Biochem 2018 Dec 6;51(5):2123-2135. Epub 2018 Dec 6.

Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou,

Background/aims: Emerging evidence suggests a close link between gut microbiota and non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the association between gut microbiota and the DNA methylation of adiponectin (an adipocyte-specific adipocytokine) in rats, following diet-induced NAFLD.

Methods: 50 male SD rats were randomly divided into five groups with or without a high fat diet (HFD), antibiotics, and probiotics, in order to establish an imbalanced gut microbiota and probiotic treatment model in NAFLD rats. Read More

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December 2018
2 Reads

Discovery and development of small molecule modulators targeting glutamine metabolism.

Eur J Med Chem 2018 Nov 28;163:215-242. Epub 2018 Nov 28.

Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China. Electronic address:

Cancer cells have been confirmed diverge significantly from normal cells on the metabolic properties. Energy production in cancer cells is abnormally dependent on the glycolysis pathway and other atypical metabolic characteristics such as increased fatty acid synthesis and increased rates of glutamine metabolism. Among these metabolic features of cancers, glutamine metabolism has been reported to be the main energy supply for the growth and viability of a potentially large subset of malignant tumors. Read More

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November 2018
5 Reads
3.447 Impact Factor

A perspective on biogenic synthesis of platinum nanoparticles and their biomedical applications.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Nov 19;211:94-99. Epub 2018 Nov 19.

Food Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management, Science Campus, Alagappa University, Karaikudi 630003, India. Electronic address:

In recent era, the interest on inorganic nanoparticles is augmenting due to their engrossing and uncanny properties. Among them, platinum nanoparticles (PtNPs) are highly remarkable owing to their intrinsic physicochemical and biological properties making them an effective candidate towards catalytic and biomedical applications. Nevertheless, conventional physical and chemical methodologies of PtNPs synthesis are among the most prevalent protocols to synthesize PtNPs of desired shape and size. Read More

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November 2018
1 Read

Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression.

J Proteomics 2018 Dec 3. Epub 2018 Dec 3.

Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China; Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Major depressive disorders impact approximately 17% of the population worldwide, whose high morbidity and considerable adversity have resulted in enormous social and economic burden. In addition, clinically depressed patients often show reduced volume of olfactory bulb (OB) and decreased olfactory sensitivity. Although mounting evidence conveyed that the gut microbiota may implicate the pathophysiology of major depressive disorder (MDD) via the microbe-gut-brain axis, knowledge about its distinctive molecular mechanism is rudimentary. Read More

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December 2018
2 Reads

Ultrasonic scalpel-assisted endoscopic endonasal surgery of infratemporal fossa: our first impressions.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, HNS&FDRc, University of Insubria, Varese, Italy.

Background: Endoscopic endonasal transpterygoid approach is emerging as a valid option for treating selected tumors in the infratemporal fossa. Compared to traditional open approaches, the endoscopic endonasal approach (EEA) presents more difficulty in controlling bleeding and less choice in surgical instruments for endoscopic tumor dissection, which is often performed with bipolar forceps or steel dissectors.

Case Description: We describe the use of an ultrasonic scalpel device for performing endoscopic endonasal resection of two rare infratemporal fossa tumors (mature teratoma and hemangiopericytoma), which has not been reported in the literature so far. Read More

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December 2018
1 Read

Body composition and sarcopenia: the next-generation of personalized oncology and pharmacology?

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Oncology, CAncer Research for PErsonalized Medicine (CARPEM), Paris Centre Teaching Hospitals, Paris Descartes University, USPC, Paris, France.

Body composition has gained increasing attention in oncology in recent years due to fact that sarcopenia has been revealed to be a strong prognostic indicator for survival across multiple stages and cancer types and a predictive factor for toxicity and surgery complications. Accumulating evidence over the last decade has unraveled the "pharmacology" of sarcopenia. Lean body mass may be more relevant to define drug dosing than the "classical" body surface area or flat-fixed dosing in patients with cancer. Read More

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December 2018
2 Reads

Differentiation between persistent infection/colonization and re-infection/re-colonization of Mycobacterium abscessus isolated from patients in Northeast Thailand.

Infect Genet Evol 2018 Dec 3. Epub 2018 Dec 3.

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Research and Diagnostic Center for Emerging Infectious Diseases, Khon Kaen University, Khon Kaen, Thailand. Electronic address:

Mycobacterium abscessus can cause true infection or be present in the host as a harmless colonist. The ability of M. abscessus to cause disease and develop drug resistance is known to have a genetic basis. Read More

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December 2018
2 Reads

Bezlotoxumab Use as Adjunctive Therapy with the Third Fecal Microbiota Transplant in Refractory Recurrent Clostridium Difficile Colitis; A Case Report and Concise Literature Review.

Anaerobe 2018 Dec 3. Epub 2018 Dec 3.

ABIM Board Certified in Focused Practice in Hospital Medicine (FPHM), Mercy Clinic Hospitalist, Physician Building, 7301 Rogers Ave, Fort Smith, AR, 72903, United States. Electronic address:

Clostridium difficile is the most commonly reported pathogen to cause nosocomial infections in the United States with a high burden affecting morbidity, mortality and healthcare expenditure. The use of Fecal Microbiota Transplantation (FMT) is one of the current standard therapies for recurrent C. difficile infection (CDIr). Read More

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December 2018
1 Read

A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses.

Antiviral Res 2018 Dec 3. Epub 2018 Dec 3.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.

Arboviruses represent a group of pathogens that can spread efficiently throughout human populations by hematophagous arthropod vectors. The mosquito-borne (re)emerging Chikungunya and Dengue viruses belong to the alphavirus and flavivirus genus, respectively, with no approved therapeutics or safe vaccines for humans. Transmitted by the same vector Aedes spp. Read More

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December 2018
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Development of a respiratory disease model for enterovirus D68 in 4-week-Old mice for evaluation of antiviral therapies.

Antiviral Res 2018 Dec 3. Epub 2018 Dec 3.

Institute for Antiviral Research, Utah State University, Logan, UT, United States; Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, United States; Utah Veterinary Diagnostic Laboratory, Logan, UT, United States. Electronic address:

Enterovirus D68 (EV-D68) is a non-polio enterovirus that affects the respiratory system and can cause serious complications, especially in children and older people with weakened immune systems. As an emerging virus, there are no current antiviral therapies or vaccines available. Our goal was to develop a mouse model of human EV-D68 infection that mimicked the disease observed in humans and could be used for evaluation of experimental therapeutics. Read More

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December 2018
6 Reads

Transmission dynamics of re-emerging rabies in domestic dogs of rural China.

PLoS Pathog 2018 Dec 6;14(12):e1007392. Epub 2018 Dec 6.

KU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Evolutionary and Computational Virology, Leuven, Belgium.

Despite ongoing efforts to control transmission, rabies prevention remains a challenge in many developing countries, especially in rural areas of China where re-emerging rabies is under-reported due to a lack of sustained animal surveillance. By taking advantage of detailed genomic and epidemiological data for the re-emerging rabies outbreak in Yunnan Province, China, collected between 1999 and 2015, we reconstruct the demographic and dispersal history of domestic dog rabies virus (RABV) as well as the dynamics of dog-to-dog and dog-to-human transmission. Phylogeographic analyses reveal a lower diffusion coefficient than previously estimated for dog RABV dissemination in northern Africa. Read More

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December 2018

A comparison of maternal and newborn health services costs in Sindh Pakistan.

PLoS One 2018 6;13(12):e0208299. Epub 2018 Dec 6.

Division of Women & Child Health, Aga Khan University, Karachi, Pakistan.

Pakistani women suffer the highest rate of maternal mortality in South Asia. A lack of comprehensive knowledge about maternal and newborn health (MNH) services costs impedes policy decisions to maximize the benefit from existing, as well as emerging, MNH interventions in Pakistan. We compared MNH service costs at different levels of care. Read More

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December 2018
2 Reads

Integrated Aedes management for the control of Aedes-borne diseases.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006845. Epub 2018 Dec 6.

MIVEGEC, IRD, CNRS, University of Montpellier, Montpellier, France.

Background: Diseases caused by Aedes-borne viruses, such as dengue, Zika, chikungunya, and yellow fever, are emerging and reemerging globally. The causes are multifactorial and include global trade, international travel, urbanisation, water storage practices, lack of resources for intervention, and an inadequate evidence base for the public health impact of Aedes control tools. National authorities need comprehensive evidence-based guidance on how and when to implement Aedes control measures tailored to local entomological and epidemiological conditions. Read More

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December 2018
3 Reads

A pragmatic cluster randomised controlled trial of a tailored intervention to improve the initial management of suspected encephalitis.

PLoS One 2018 6;13(12):e0202257. Epub 2018 Dec 6.

Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.

Objective: To determine whether a tailored multifaceted implementation strategy improves the initial management of patients with suspected encephalitis.

Design: Pragmatic two arm cluster randomised controlled trial.

Setting: Hospitals within the United Kingdom. Read More

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December 2018
10 Reads

Building the evidence base for dengue vector control: searching for certainty in an uncertain world.

Pathog Glob Health 2018 Dec 6:1-9. Epub 2018 Dec 6.

a Heidelberg Institute of Global Health , University of Heidelberg , Germany.

This review discusses biological and chemical methods for dengue vector control, using recently emerging summary evidence, meta-analyses and systematic reviews to conclude on practical public health recommendations for Aedes control, which is increasingly relevant in an era of widespread Chikungunya, yellow feer and Zika outbreaks. The analysis follows an a priori framework of systematic reviews by the authors on vector control methods, distinguishing vector control methods into biological, chemical and environmental methods. Findings of each published systematic review by the authors, following each individual vector control method, are summarised and compared in the discussion against the findings of existing meta-analyses covering all vector control methods. Read More

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December 2018
1 Read

Blocking Tyr265 nitration of protein phosphatase 2A attenuates nitrosative stress-induced endothelial dysfunction in renal microvessels.

FASEB J 2018 Dec 6:fj201800885RR. Epub 2018 Dec 6.

Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Protein tyrosine (Tyr) nitration, the covalent addition of a nitro group (NO) to Tyr residues, is emerging as a candidate mechanism of endothelial dysfunction. Previous studies have shown that Tyr nitration is primarily induced by nitrosative stress, a process characterized by the production of reactive nitrogen species, especially peroxynitrite anion (ONOO), which is considered a secondary product of NO in the presence of superoxide radicals (O). However, the impact of nitrosative stress-induced Tyr nitration on endothelial dysfunction has not been thoroughly elucidated to date. Read More

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December 2018

Metal-ligand interface in the chemical reactions of ligand protected noble metal clusters.

Langmuir 2018 Dec 6. Epub 2018 Dec 6.

We discuss the role of the metal-ligand (M-L) interfaces in the chemistry of ligand protected, atomically precise noble metal clusters, a new and expanding family of nanosystems, in solution as well as in gas phase. A few possible mechanisms in which the structure and dynamics of M-L interfaces could trigger intercluster exchange reactions are presented first. How interparticle chemistry can be a potential mechanism of Ostwald ripening, a well-known particle coarsening process, is also discussed. Read More

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December 2018
5 Reads
4.457 Impact Factor

Towards Automated Tools for Characterization of Molecular Porosity.

J Chem Theory Comput 2018 Dec 6. Epub 2018 Dec 6.

The emerging advanced porous materials, e.g. extended framework materials and porous molecular materials, offer an unprecedented level of control of their structure and function. Read More

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December 2018

Legacy and Emerging Persistent Organic Pollutants (POPs) in Terrestrial Compartments in the High Arctic: Sorption and Secondary Sources.

Environ Sci Technol 2018 Dec 6. Epub 2018 Dec 6.

Department of Geography and Planning , Queen's University , Kingston , Ontario K7L 3N6 , Canada.

Legacy persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and emerging perfluoroalkyl substances (PFASs) were measured in vegetation and soil samples collected at remote lakes in the Canadian High Arctic. Field studies were carried out in 2015 and 2016 to assess concentrations of POPs, study the relevant sorbing phases, and determine whether Arctic soils were sinks or sources of legacy POPs to the atmosphere and to neighboring lakes. The patterns of legacy POPs in vegetation and soils were dominated by low molecular weight PCB congeners along with OCPs, confirming the importance of long-range atmospheric transport. Read More

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December 2018

A Radical Approach to Enzymatic β-Thioether Bond Formation.

J Am Chem Soc 2018 Dec 6. Epub 2018 Dec 6.

Ribosomally-synthesized and post-translationally-modified peptides (RiPPs) are an emerging class of natural products that harbor diverse chemical functionalities, usually introduced via the action of a small number of tailoring enzymes. We have been interested in RiPP biosynthetic gene clusters that encode unusual metalloenzymes, as these may install yet unknown alterations. Using a new bioinformatic search strategy, we recently identified an array of unexplored RiPP gene clusters that are quorum sensing-regulated and contain one or more uncharacterized radical S-adenosylmethionine (RaS) metalloenzymes. Read More

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December 2018
1 Read

Methane production and emissions in trees and forests.

New Phytol 2018 Dec 6. Epub 2018 Dec 6.

Smithsonian Environmental Research Center, 647 Contees Wharf Road, Edgewater, MD, 21037.

Forest ecosystem methane (CH ) research has focused on soils, but trees are also important sources and sinks in forest CH budgets. Living and dead trees transport and emit CH produced in soils; living trees and deadwood emit CH produced inside trees by microorganisms; and trees produce CH through an abiotic photochemical process. Here, we review the state of the science on the production, consumption, transport, and emission of CH by living and dead trees, and the spatial and temporal dynamics of these processes across hydrologic gradients inclusive of wetland and upland ecosystems. Read More

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December 2018
2 Reads

Challenges of Differential Placebo Effects in Contemporary Medicine: The Example of Brain Stimulation.

Ann Neurol 2018 Dec 6. Epub 2018 Dec 6.

Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

'Differential placebo effects' is the concept that different types of placebos (e.g. inert pill versus sham device) may yield different magnitudes of placebo effects. Read More

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December 2018
1 Read

Oligometastatic prostate cancer: Reality or figment of imagination.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation and Cellular Oncology, The University of Chicago Medicine, Chicago, Illinois.

The term "oligometastatic prostate cancer" refers to a heterogeneous group of disease states currently defined solely on the basis of clinical features. Oligorecurrent disease, de novo oligometastases, and oligoprogressive disease likely have unique biologic underpinnings and natural histories. Evidence suggesting the existence of a subset of patients who harbor prostate cancer with limited metastatic potential currently includes disparate and overwhelmingly retrospective reports. Read More

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December 2018
1 Read

Massive Localized Lymphedema, an Emerging Problem and a Challenging Pseudosarcomatous Condition Mimicking Liposarcoma.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, University of Colorado Denver School of Medicine, 80206 Denver, USA.

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December 2018
1 Read

Emerging evidence of an effect of salt on innate and adaptive immunity.

Nephrol Dial Transplant 2018 Dec 5. Epub 2018 Dec 5.

Department of Renal Medicine, University College London (UCL), London, UK.

Salt intake as part of a western diet currently exceeds recommended limits, and the small amount found in the natural diet enjoyed by our Paleolithic ancestors. Excess salt is associated with the development of hypertension and cardiovascular disease, but other adverse effects of excess salt intake are beginning to be recognized, including the development of autoimmune and inflammatory disease. Over the last decade there has been an increasing body of evidence demonstrating that salt affects multiple components of both the innate and adaptive immune systems. Read More

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December 2018
1 Read

Computer vision-based phenotyping for improvement of plant productivity: A machine learning perspective.

Gigascience 2018 Dec 6. Epub 2018 Dec 6.

Department of Information Engineering and Computer Science, University of Trento, Via Sommarive 9, 38123 Trento, Italy.

Employing computer vision to extract useful information from images and videos is becoming a key technique for identifying phenotypic changes in plants. In this report, we review the emerging aspects of computer vision for automated plant phenotyping. Recent advances in image analysis empowered by machine learning-based techniques, including convolutional neural network-based modeling, have expanded their application to assist high-throughput plant phenotyping. Read More

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December 2018

Direct sampling mass spectrometry for clinical analysis.

Analyst 2018 Dec 6. Epub 2018 Dec 6.

State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing, 100084, China and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA and Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.

Direct sampling mass spectrometry (MS) has been advancing aggressively, showing immense potential in translating MS into the clinical field. Unlike traditional MS analysis involving extensive sample preparation and chromatographic separation, quick and simple procedures with minimal sample pretreatment or purification became available with direct sampling. An overview of the development in this field is provided, including some representative ambient ionization and fast extraction methods. Read More

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December 2018

Inpatients Sign On: An Opportunity to Engage Hospitalized Patients and Caregivers Using Inpatient Portals.

Med Care 2018 Dec 4. Epub 2018 Dec 4.

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health.

Background: Inpatient portals are online patient portals linked to electronic health records that provide hospitalized patients and caregivers secure access to real-time clinical information and tools to enhance their communication with providers and hospital experience.

Objective: The main objective of this commentary was to provide a perspective that inpatient portals are innovative tools poised to engage patients and caregivers during hospitalization and, thus, enhance patient-centered care.

Results: Inpatient portals are desired by patients and caregivers and may contribute to improved recognition of their inpatient care team, knowledge of their treatment plan and overall inpatient experience. Read More

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December 2018

New Educator Roles for Health Systems Science: Implications of New Physician Competencies for U.S. Medical School Faculty.

Acad Med 2018 Dec 4. Epub 2018 Dec 4.

J.D. Gonzalo is associate professor of medicine and public health sciences and associate dean for health systems education, Penn State College of Medicine, Hershey, Pennsylvania; ORCID: http://orcid.org/0000-0003-1253-2963. A. Chang is professor of medicine, Gold-Headed Cane Endowed Education Chair in Internal Medicine, University of California, San Francisco, School of Medicine, San Francisco, California. D. R. Wolpaw is professor of medicine and humanities, Penn State College of Medicine, Hershey, Pennsylvania; ORCID: http://orcid.org/0000-0002-7567-2034.

To address gaps in U.S. health care outcomes, medical education is evolving to incorporate new competencies, as well as to align with care delivery transformation and prepare systems-ready providers. Read More

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December 2018

Everything in its right place: resident memory CD8+ T cell immunosurveillance of HIV infection.

Curr Opin HIV AIDS 2018 Dec 4. Epub 2018 Dec 4.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose Of Review: To introduce emerging concepts in tissue resident CD8 T cell immunosurveillance and their relevance to control HIV infection.

Recent Findings: It is well appreciated that HIV preferentially infects and persists in CD4 T cells located in gut and in lymphoid tissue, yet the majority of known immunological correlates of HIV control are derived from peripheral blood. Instead, tissue-based immunological surveillance likely dictates the course of infection. Read More

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December 2018
1 Read

RNA regulons are essential in intestinal homeostasis.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.

Pediatrics, GI Division, Children's Hospital of Philadelphia, United States.

Intestinal epithelial cells are among the most rapidly proliferating cell types in the human body. There are several different sub-types of epithelial cells, each with unique functional roles in responding to the ever-changing environment. The epithelium's ability for rapid and customized responses to environmental changes requires multi-tiered levels of gene regulation. Read More

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December 2018

Noninterleaved Metasurface for (2-1) Spin- and Wavelength-Encoded Holograms.

Nano Lett 2018 Dec 6. Epub 2018 Dec 6.

Department of Electrical and Computer Engineering , National University of Singapore , 4 Engineering Drive 3 , Singapore 117583 , Singapore.

Nanostructured metasurfaces demonstrate extraordinary capabilities to control light at the subwavelength scale, emerging as key optical components to physical realization of multitasked devices. Progress in multitasked metasurfaces has been witnessed in making a single metasurface multitasked by mainly resorting to extra spatial freedom, for example, interleaved subarrays, different angles. However, it imposes a challenge of suppressing the cross-talk among multiwavelength without the help of extra spatial freedom. Read More

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December 2018
5 Reads

Facile Synthesis of Amorphous Ternary Metal Borides - Reduced Graphene Oxide Hybrid with Superior Oxygen Evolution Activity.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Metal borides represent an emerging family of advanced electrocatalyst for oxygen evolution reaction (OER). Herein, we present a fast and simple method of synthesizing iron-doped amorphous nickel boride on reduced graphene oxide (rGO) sheets. The hybrid exhibits outstanding OER performance and stability in prolonged OER operation. Read More

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December 2018
1 Read

Proteins regulating microvesicle biogenesis and multidrug resistance in cancer.

Authors:
J Taylor M Bebawy

Proteomics 2018 Dec 6:e1800165. Epub 2018 Dec 6.

Discipline of Pharmacy, Graduate School of Health, The University of Technology Sydney, Sydney, Australia.

Microvesicles (MV) are emerging as important mediators of intercellular communication. These signalling vectors are implicated in physiological processes ranging from vascular homeostasis to inflammation. They also play an important role in the cancer pathology and progression. Read More

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December 2018
1 Read

Management of adverse reactions to high-dose moxifloxacin used in multidrug-resistant tuberculosis treatment programmes.

Respirology 2018 Dec 6. Epub 2018 Dec 6.

Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China.

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December 2018

Bacterial detection and identification from human synovial fluids on an integrated microfluidic system.

Analyst 2018 Dec 6. Epub 2018 Dec 6.

Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan. and Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan and Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan.

Periprosthetic joint infections (PJIs) are among the most severe complications emerging from prosthetic joint replacement surgeries. In order to possess a rapid means of diagnosing PJIs, an integrated microfluidic system was developed herein for detecting and identifying bacteria in human synovial fluid (HSF). The entire molecular diagnostic process, including (1) sample treatment, (2) bacterial isolation, (3) bacterial lysis, (4) nucleic acid amplification (via polymerase chain reaction (PCR)), and (5) optical detection, could be automated on a single chip. Read More

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December 2018

Optimization of a depth of interaction encoding PET block detector for a PET/MRI insert.

Phys Med Biol 2018 Dec 6;63(23):235031. Epub 2018 Dec 6.

Department of Biomedical Engineering, UC Davis, Davis, California, United States of America. Author to whom any correspondence should be addressed.

Preclinical positron emission tomography, combined with magnetic resonance imaging (PET/MRI), is increasingly used as a tool to simultaneously characterize functional processes in vivo. Many emerging preclinical applications, however, are limited by PET detection sensitivity, especially when generating short imaging frames for quantitative studies. One such application is dynamic multifunctional imaging, which probes multiple aspects of a biological process, using relationships between the datasets to quantify interactions. Read More

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December 2018
1 Read

The emerging role of liquid biopsy in diagnosis, prognosis and treatment monitoring of pancreatic cancer.

Pharmacogenomics 2018 Dec 6. Epub 2018 Dec 6.

Unit of Clinical Pharmacology & Pharmacogenetics, Department of Clinical & Experimental Medicine, University of Pisa, Italy.

Circulating tumor DNA, circulating tumor cells and tumor-related exosomes may offer new opportunities to provide insights into the biological and clinical characteristics of a neoplastic disease. They represent alternative routes for diagnostic and prognostic purposes, and for predicting and longitudinally monitoring response to treatment and disease progression. Hence, circulating biomarkers represent promising noninvasive tools in the scenario of pancreatic cancer, where neither molecular nor clinical predictors of treatment benefit have been identified yet. Read More

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December 2018

Emerging Design and Characterization Guidelines for Polymer-Based Infrared Photodetectors.

Acc Chem Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Electrical and Computer Engineering , University of California San Diego , 9500 Gilman Drive , La Jolla , California 92093-0407 , United States.

Infrared photodetectors are essential to many applications, including surveillance, communications, process monitoring, and biological imaging. The short-wave infrared (SWIR) spectral region (λ = 1-3 μm) is particularly powerful for health monitoring and medical diagnostics because biological tissues show low absorbance and minimal SWIR autofluorescence, enabling greater penetration depth and improved resolution in comparison with visible light. However, current SWIR photodetection technologies are largely based on epitaxially grown inorganic semiconductors, which are costly, require complex processing, and impose cooling requirements incompatible with wearable electronics. Read More

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December 2018

hsa_circRNA_0006528 as a competing endogenous RNA promotes human breast cancer progression by sponging miR-7-5p and activating the MAPK/ERK signalling pathway.

Mol Carcinog 2018 Dec 5. Epub 2018 Dec 5.

Oncology Institute, Affiliated Hospital of Jiangnan University, Wuxi 214062, China.

Emerging research has indicated that circular RNAs (circRNAs), a novel class of non-coding RNAs, play a vital role in human tumourigenesis and progression. Our previous results suggested that hsa_circ_0006528 (circ_0006528), a circRNA with an unknown function, mediates adriamycin resistance in human breast cancer cells. However, the role of circ_0006528 in breast cancer progression remains unknown. Read More

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December 2018

A seed change in our understanding of legume biology from genomics to the efficient cooperation between nodulation and arbuscular mycorrhizal fungi.

Plant Cell Environ 2018 Sep;41(9):1949-1954

Centre for Soybean Research, Partner State Key Laboratory of Agrobiotechnology and School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.

Grain legumes play a significant role in global food security. They have an advantage over cereals in that they can form symbiotic associations with nitrogen-fixing bacteria, making them self-sufficient in terms of nitrogen acquisition. In addition to this superior agronomic trait, grain legumes have excellent nutritional properties and are thus widely used as animal feed as well as in human nutrition. Read More

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September 2018

Nanoparticle-biomolecular corona: A new approach for the early detection of non-small-cell lung cancer.

J Cell Physiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.

Lung cancer (LC) is the most common type of cancer and the second cause of death worldwide in men and women after cardiovascular diseases. Non-small-cell lung cancer (NSCLC) is the most frequent type of LC occurring in 85% of cases. Developing new methods for early detection of NSCLC could substantially increase the chances of survival and, therefore, is an urgent task for current research. Read More

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December 2018
1 Read

In Silico Target Prediction for Small Molecules.

Methods Mol Biol 2019 ;1888:273-309

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland.

Drugs modulate disease states through their actions on targets in the body. Determining these targets aids the focused development of new treatments, and helps to better characterize those already employed. One means of accomplishing this is through the deployment of in silico methodologies, harnessing computational analytical and predictive power to produce educated hypotheses for experimental verification. Read More

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January 2019

The Longitudinal Associations Between Outness and Health Outcomes Among Gay/Lesbian Versus Bisexual Emerging Adults.

Arch Sex Behav 2018 Dec 5. Epub 2018 Dec 5.

Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, 625 N Michigan Ave., #14-047, Chicago, IL, 60611, USA.

Sexual minorities are at increased risk for substance use and mental health problems. Although previous studies have examined the associations between outness and health outcomes, few have used longitudinal designs or examined differences across subgroups of sexual minorities. To address these gaps, the current study examined sexual orientation and gender as moderators of the longitudinal associations between outness and substance use (cigarettes, marijuana, illicit drugs, and alcohol) and mental health (depression and anxiety). Read More

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December 2018
1 Read

Symptoms and Impacts in Metastatic Castration-Resistant Prostate Cancer: Qualitative Findings from Patient and Physician Interviews.

Patient 2018 Dec 6. Epub 2018 Dec 6.

Astellas Pharma Inc., Northbrook, IL, USA.

Background: There is little information available on health-related quality of life in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer. This study aimed to develop a conceptual model that describes patients' experiences of living with this condition.

Methods: This was a cross-sectional, non-interventional qualitative research study. Read More

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December 2018

Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases.

Geroscience 2018 Dec 5. Epub 2018 Dec 5.

Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, 277 McElroy Hall, Stillwater, OK, 74078, USA.

Chronic sympathetic nervous system overactivity is a hallmark of aging and obesity and contributes to the development of cardiovascular diseases including hypertension and heart failure. The cause of this chronic sympathoexcitation in aging and obesity is multifactorial and centrally mediated. In this mini-review, we have provided an overview of the key and emerging central mechanisms contributing to the pathogenesis of sympathoexcitation in obesity and healthy aging, specifically focusing on hypertension. Read More

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December 2018