Search Our Scientific Publications & Authors

J Thorac Cardiovasc Surg 2020 May 6. Epub 2020 May 6.

Department of Thoracic and Cardiovascular Surgery, West German Heart and Vascular Center Essen, University Hospital Essen, Essen, Germany.

Objective: Acute type I aortic dissection (AAD) represents a surgical emergency with time-dependent evolving complications. Frozen elephant trunk (FET) enables false lumen exclusion downstream but is still debated in AAD due to its greater dimension of surgery. To combine the benefits of fast proximal repair with the FET benefits, a 3-zone hybrid graft was developed consisting of an ascending polyester portion, an arch noncovered stent, and a descending stent graft. Read More

Neurol Sci 2020 Jul 9. Epub 2020 Jul 9.

Division of Neurosurgery, Department of Biotechnology and Life Sciences, University of Insubria, Via Guicciardini, 9, 21100, Varese, Italy.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the infectious agent responsible for coronavirus disease 2019 (COVID-19). Respiratory and gastrointestinal manifestations of SARS-CoV-2 are well described, less defined is the clinical neurological spectrum of COVID-19. We reported a case of COVID-19 patient with acute monophasic Guillain-Barré syndrome (GBS), and a literature review on the SARS-CoV-2 and GBS etiological correlation. Read More

Mayo Clin Proc 2020 Jul;95(7):1512-1529

Departments of Neurology and Neurologic Surgery, Mayo Clinic, Jacksonville, FL.

In this comprehensive contemporary review of acute ischemic stroke management, what is new and different will be highlighted beginning with prehospital stroke systems of care, emergency medical systems, and mobile stroke units, followed by hospital stroke teams, emergency evaluation, telemedicine, and brain and vascular imaging, and finishing with emergency treatments including thrombolysis and mechanical thrombectomy. Read More

Neurology 2020 Jul 1. Epub 2020 Jul 1.

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia

Objective: To assess the prevalence of brain MRI abnormalities in people with epilepsy in rural China and to compare this with individuals in the United Kingdom.

Methods: Brain MRI scans were obtained in people with epilepsy who participated in a rural community-based program in China between July 2010 and December 2012. Individual epileptogenic lesion types were reviewed and their associations with seizure control examined. Read More

Emerg Radiol 2020 Jun 26. Epub 2020 Jun 26.

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Division of Radiology, University of Messina, AOU Policlinico Universitario G. Martino, Via Consolare Valeria 1, 98100, Messina, Italy.

Acute scrotal pain is one of the most frequent symptoms in pediatric patients visited in the Emergency Department. Ultrasonography with color and power Doppler represents the first-line method that clinicians use to carry out the differential diagnosis between spermatic cord torsion and inflammation, but sensitivity and specificity are 63-100% and 97-100%, respectively; this variability may be related to operator's experience and testis vascular hemodynamics and also to machine performance and patient age. Recent technological innovations have made possible to create a new Doppler mode called ultrasound microvascular imaging. Read More

Stroke 2020 07 17;51(7):1928-1931. Epub 2020 Jun 17.

Department of Clinical Neurosciences (M.G., J.M.O.), University of Calgary, Canada.

Stroke 2020 Jul 17;51(7):2051-2057. Epub 2020 Jun 17.

Emergency Department Stroke Unit, Sapienza University Hospital, Rome (E.N., D.T.).

Background And Purpose: To evaluate outcome and safety of endovascular treatment beyond 6 hours of onset of ischemic stroke due to large vessel occlusion in the anterior circulation, in routine clinical practice.

Methods: From the Italian Registry of Endovascular Thrombectomy, we extracted clinical and outcome data of patients treated for stroke of known onset beyond 6 hours. Additional inclusion criteria were prestroke modified Rankin Scale score ≤2 and ASPECTS score ≥6. Read More

Stroke 2020 Jul 17;51(7):1951-1960. Epub 2020 Jun 17.

Department of Diagnostic Imaging (R.A.M., R.A.H., M.V.J.), Warren Alpert School of Medicine at Brown University, Providence, RI.

J Neurointerv Surg 2020 Jun 16. Epub 2020 Jun 16.

Neurosurgery, University of Cape Town, Cape Town, W Cape, South Africa.

Background: This survey was focused on the provision of neurointerventional services, the current practices of managing patients under COVID-19 conditions, and the expectations for the future.

Methods: Invitations for this survey were sent out as a collaborative effort of the European Society of Minimally Invasive Neurological Therapy (ESMINT), the Society of NeuroInterventional Surgery (SNIS), the Sociedad Iberolatinoamericana de Neuroradiologia Diagnostica y Terapeutica (SILAN), the Society of Vascular and Interventional Neurology (SVIN), and the World Federation of Interventional and Therapeutic Neuroradiology (WFITN).

Results: Overall, 475 participants from 61 countries responded (six from Africa (1%), 81 from Asia (17%), 156 from Europe (33%), 53 from Latin America (11%), and 172 from North America (11%)). Read More

Pediatr Emerg Care 2020 Jun 12. Epub 2020 Jun 12.

Division of Pediatric Neurology, the University of Vermont Medical Center, Burlington, VT.

Objectives: To evaluate changes in imaging practices for pediatric head trauma after publication of the Pediatric Emergency Care Applied Research Network (PECARN) guidelines, explore areas for quality improvement regarding neuroradiology referrals. We also sought to determine the prevalence of incidental findings discovered on computed tomographies (CTs) attained for minor head trauma and ascertain disposition in these cases.

Methods: This retrospective study was conducted at a rural academic center and included 156 children who received CTs for head trauma between 2005 and 2015. Read More

Air Med J 2020 May - Jun;39(3):166-172. Epub 2020 Apr 7.

Program in Trauma, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD; Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD.

Objective: Mechanical thrombectomy is the treatment of choice for acute ischemic strokes from large vessel occlusions. Absolute blood pressure and blood pressure variability (BPV) may affect patients' outcome. We hypothesized that patients' outcomes were not associated with BPV during transport between hospitals in the era of effective thrombectomy. Read More

Turk Neurosurg 2020 May 20. Epub 2020 May 20.

University of Health Sciences, Gaziosmanpasa Training and Resarch Hospital, Department of Neurosurgery, Istanbul, Turkey.

Aim: To reveal difficulties in differential diagnosis of some cases of cerebrovascular events (CVE)) and malignant primary brain tumors (MBT) even a multidiciplinary evaluation in Grand rounds.

Material And Methods: This study retrospectively analyzed the patient archives from January 2017-January 2020. The records of 572 patients discussed in these meetings were examined. Read More

Childs Nerv Syst 2020 Jun 9. Epub 2020 Jun 9.

Department of Pediatric Neurosciences, Pediatric Neurosurgery Unit, Santobono-Pausilipon Children's Hospital, Via Mario Fiore n. 6, 80129, Naples, Italy.

Introduction: Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder affecting multiple systems, due to inactivating mutations of TSC1 or TSC2 mTOR pathway genes. Neurological manifestations are observed in about 95% cases, representing the most frequent cause of morbidity and one of the most common causes of mortality.

Background: Neuroimaging is crucial for early diagnosis, monitoring, and management of these patients. Read More

Childs Nerv Syst 2020 Jun 7. Epub 2020 Jun 7.

Department of Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.

Introduction: Hemangioblastomas are rare, histologically benign, highly vascularized tumors of the brain, the spinal cord, and the retina, occurring sporadically or associated with the autosomal dominant inherited von Hippel-Lindau (VHL) disease. Children or adults with VHL disease have one of > 300 known germline mutations of the VHL gene located on chromosome 3. They are prone to develop hemangioblastomas, extremely rarely starting at age 6, rarely at age 12-18, and, typically and almost all, as adults. Read More

Radiol Med 2020 Jul 4;125(7):691-694. Epub 2020 Jun 4.

Department of Directional Hospital Management, Azienda Ospedaliera Di Padova, Padova, Italy.

The current COVID-19 outbreak is requiring a tremendous effort not only regarding the diagnostic and therapeutic approach but also in terms of global management of the delivered care. Hospital administrations had to provide a prompt response to a rapidly evolving emergency characterized by the necessity of giving access to an enormous number of infected patients, guaranteeing appropriate care to patients in need of other types of treatment, and simultaneously preserving the well-being of healthcare providers. To optimize the diagnostic pathway during the current COVID-19 outbreak, the hospital administration of our tertiary center applied a highly structured framework assigning specific tasks to the different units composing the Department of Imaging. Read More

Quant Imaging Med Surg 2020 May;10(5):1045-1057

Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

The COVID-19 pandemic seriously threatens the lives of the general public and poses momentous challenges to all medical workers, including those engaged in interventional radiology, who play an important role in the diagnosis and treatment of various diseases. To further standardize the prevention and control of nosocomial infections and ensure the safety of doctors and patients, the Chinese Society of Interventional Radiology (CSIR) organized multidisciplinary experts in the field of interventional radiology in China to prepare an "Expert Consensus" elaborating and summarizing the protective strategies and suggestions for medical workers in the field of interventional radiology when they engage in interventional diagnosis and treatment activities against the background of novel coronavirus infection control. The aim is to provide a reference for interventional procedures in hospitals and other medical institutions at all levels in China and worldwide. Read More

J Child Neurol 2020 Jun 2:883073820924985. Epub 2020 Jun 2.

Section of Clinical Genetics and Metabolism, Department of Pediatrics, Children's Hospital of Colorado, University of Colorado Denver, Aurora, CO, USA.

Krabbe disease is a progressive neurologic disorder caused by deficiency of the lysosomal enzyme galactocerebrosidase. The disease commonly has an early-infantile onset, but can have late-infantile, juvenile, or adult-onset phenotypes. Classic computed tomography (CT) and magnetic resonance imaging (MRI) findings in Krabbe have been well described. Read More

J Am Coll Radiol 2020 Jul 19;17(7):882-889. Epub 2020 May 19.

Vice Chair of Operations, Department of Radiology, University of Cincinnati, Cincinnati, Ohio.

Objective: To meet hospital preparedness for the coronavirus disease 2019 pandemic, the Centers for Disease Control and Prevention and ACR recommended delay of all nonemergent tests and elective procedures. The purpose of this article is to report our experience for rescheduling nonemergent imaging and procedures during the pandemic at our tertiary academic institution.

Methods: We rescheduled the nonemergent imaging and procedures in our hospitals and outpatient centers from March 16 to May 4, 2020. Read More

Stroke 2020 May 29:STROKEAHA120030106. Epub 2020 May 29.

Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Instituto de Biomedicina de Sevilla-IBiS, Barcelona, Spain (J.M., A.G.).

Background And Purpose: Emergency measures to treat patients with coronavirus 2019 (COVID-19) and contain the outbreak is the main priority in each of our hospitals; however, these measures are likely to result in collateral damage among patients with other acute diseases. Here, we investigate whether the COVID-19 pandemic affects acute stroke care through interruptions in the stroke chain of survival.

Methods: A descriptive analysis of acute stroke care activity before and after the COVID-19 outbreak is given for a stroke network in southern Europe. Read More

World Neurosurg 2020 May 24. Epub 2020 May 24.

Interventional Neuroradiology Service - Department of Radiology, Austin Hospital, Melbourne, Australia; Interventional Neuroradiology Service - Department of Radiology, Monash Health, Melbourne, Australia; School of Medicine - Faculty of Health, Deakin University, Waurn Ponds, Australia; Interventional Radiology Service - Department of Radiology, St Vincent's Hospital, Melbourne, Australia; Stroke Theme, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.

Background: Endovascular clot retrieval (ECR) is the standard of care for acute ischaemic stroke caused by large vessel occlusion. Reducing stroke symptom onset to reperfusion time is associated with improved functional outcomes. This study aims to develop a computational model to predict and identify time-related outcomes of community stroke calls within a geographic area based on variable parameters to support planning and coordination of ECR services. Read More

J Clin Med 2020 May 18;9(5). Epub 2020 May 18.

Pediatric Radiology Department, Necker Enfants Malades & GHU Paris, Sainte-Anne Hospital, Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR S1266, INSERM, Université de Paris, 75015 Paris, France.

Hemorrhagic strokes account for half of all strokes seen in children, and the etiologies of these hemorrhagic strokes differ greatly from those seen in adult patients. This review gives an overview about incidence and etiologies as well as presentation of children with intracerebral hemorrhage and with differential diagnoses in the emergency department. Most importantly it describes how neuroimaging of children with intracerebral hemorrhage should be tailored to specific situations and clinical contexts and recommends specific imaging protocols for acute and repeat imaging. Read More

J Neurosurg Pediatr 2020 May 22:1-5. Epub 2020 May 22.

1APHP, Necker Hospital, Université de Paris.

Objective: Hydrocephalus is a strong determinant of poor neurological outcome after intracerebral hemorrhage (ICH). In children, ruptured brain arteriovenous malformations (bAVMs) are the dominant cause of ICH. In a large prospective cohort of pediatric patients with ruptured bAVMs, the authors analyzed the rates and predictive factors of hydrocephalus requiring acute external ventricular drainage (EVD) or ventriculoperitoneal shunt (VPS). Read More

J Neurointerv Surg 2020 Jul 20;12(7):643-647. Epub 2020 May 20.

Neurosurgery, Lenox Hill Hospital, New York, New York, USA.

Background: Infection from the SARS-CoV-2 virus has led to the COVID-19 pandemic. Given the large number of patients affected, healthcare personnel and facility resources are stretched to the limit; however, the need for urgent and emergent neurosurgical care continues. This article describes best practices when performing neurosurgical procedures on patients with COVID-19 based on multi-institutional experiences. Read More

World Neurosurg 2020 May 17;140:213-218. Epub 2020 May 17.

Radiology and Neuroradiology, Department of Diagnostic for Images, Oncological Radiotherapy and Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background: Postinfectious Moyamoya syndrome (MMS) is a rare vasculopathy that can follow meningitis. Only 9 cases of MMS after meningitis have been reported in the literature. We present a unique case of MMS after meningitis caused by Aspergillus fumigatus and Escherichia coli and review all cases of MMS postmeningitis in the literature. Read More

Stroke 2020 07 20;51(7):1996-2001. Epub 2020 May 20.

Department of Anesthesiology and Critical Care (R.L.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

Background And Purpose: When the coronavirus disease 2019 (COVID-19) outbreak became paramount, medical care for other devastating diseases was negatively impacted. In this study, we investigated the impact of the COVID-19 outbreak on stroke care across China.

Methods: Data from the Big Data Observatory Platform for Stroke of China consisting of 280 hospitals across China demonstrated a significant drop in the number of cases of thrombolysis and thrombectomy. Read More

Eur J Neurol 2020 May 16. Epub 2020 May 16.

Stroke Unit, Department of Neurology, Hospital Universitario Miguel Servet, Zaragoza, Spain.

Background And Purpose: Stroke assistance is facing changes and new challenges since COVID-19 became pandemic. A variation on the patient influx might be one of the greater concerns, due to fewer people coming to emergency departments or coming too late. However, no data quantifying this have been published until now. Read More

J Stroke Cerebrovasc Dis 2020 Jul 13;29(7):104916. Epub 2020 May 13.

Division of Neurocritical Care and Emergency Neurology, Yale New Haven Hospital, New Haven, CT, USA. Electronic address:

Background/objective: Malignant edema can be a life-threatening complication of large hemispheric infarction (LHI), and is often treated with osmotherapy. In this exploratory analysis of data from the GAMES-RP study, we hypothesized that patients receiving osmotherapy had symptomatic cerebral edema, and that treatment with intravenous (IV) glibenclamide would modify osmotherapy use as compared with placebo.

Methods: GAMES-RP was a phase 2 multi-center prospective, double blind, randomized, placebo-controlled study in LHI. Read More

Stroke Vasc Neurol 2020 Jun 13;5(2):152-158. Epub 2020 May 13.

Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University; Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China

Aim: Cerebral venous sinus thrombosis (CVST) is a less common cerebrovascular disease that predominantly affects young patients. The incidence of CVST is 2-5/10 000 000/year, accounting for 0.5%-1% of all stroke. Read More

Stroke 2020 07 13;51(7):e139-e140. Epub 2020 May 13.

Unit of Diagnostic Imaging, Department of Radiological Sciences, Azienda ospedaliero-universitaria Senese Department of Medicine, Surgery and Neuroscience University of Siena Siena, Tuscany, Italy (M.A.M.).

Clin Neuroradiol 2020 May 7. Epub 2020 May 7.

Department of Neuroradiology, Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.

Purpose: Cangrelor is an intravenous P2Y12 receptor inhibitor with a rapid onset/offset of action and a short half-life (3-6 min). The objective was to present a preliminary experience regarding the safety and effectiveness using cangrelor, in combination with aspirin, in acute ischemic stroke patients requiring acute stenting.

Material And Methods: Retrospective analysis for patients who underwent stenting (intracranial and/or extracranial) in the setting of acute ischemic stroke with cangrelor and aspirin as antiplatelet therapy. Read More

Mayo Clin Proc 2020 May;95(5):955-965

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts General Hospital, Boston.

Objective: To determine whether brain volume is associated with functional outcome after acute ischemic stroke (AIS).

Patients And Methods: This study was conducted between July 1, 2014, and March 16, 2019. We analyzed cross-sectional data of the multisite, international hospital-based MRI-Genetics Interface Exploration study with clinical brain magnetic resonance imaging obtained on admission for index stroke and functional outcome assessment. Read More

World Neurosurg 2020 06 27;138:548-550. Epub 2020 Apr 27.

Division of Neurosurgery, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

Stroke 2020 06 29;51(6):1896-1901. Epub 2020 Apr 29.

Department of Neurology, UCLA Comprehensive Stroke Center, CA (D.S.L.).

Eur J Neurol 2020 Apr 26. Epub 2020 Apr 26.

Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.

Background And Purpose: Although patient-centredness is considered a key component of high-quality neurological care, it is unclear to what extent it can or should be implemented during the acute phase. Using acute stroke as an example, the aim was to identify critical junctures for patient-centredness along the acute care pathway from the perspectives of patients, relatives and staff.

Methods: A qualitative multi-method study was conducted including 27 non-participant observations and 37 semi-structured interviews with patients, relatives and staff. Read More

Neuroradiology 2020 Apr 25. Epub 2020 Apr 25.

Division of Diagnostic Imaging, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Derech Sheba St 2, Ramat Gan, Israel.

Purpose: Natural language processing (NLP) can be used for automatic flagging of radiology reports. We assessed deep learning models for classifying non-English head CT reports.

Methods: We retrospectively collected head CT reports (2011-2018). Read More

Neurology 2020 Jun 23;94(24):e2577-e2580. Epub 2020 Apr 23.

From the Departments of Neuroradiology (N.S., N.D., M.E.-K., R.W., F.K.-W.) and Neurology (U.F., C.J.S.), Inselspital, Bern University Hospital, University of Bern, Switzerland.

Objective: This case series describes and discusses the potential clinical utility of a prominent vein (index vein) found on susceptibility-weighted MRI during migraine aura that drains the cortical area responsible for patients' symptoms.

Methods: Six patients with acute migraine aura had a prominent draining sulcal vein on emergency MRI done initially for suspected stroke. The location of the prominent vein was correlated to patients' symptoms, and the diameter was compared to the corresponding contralateral vein. Read More

Acta Neurochir (Wien) 2020 06 21;162(6):1225-1226. Epub 2020 Apr 21.

School of Medicine and Surgery, Università degli Studi di Milano Bicocca, Milano, Italy.

Case Rep Neurol 2020 Jan-Apr;12(1):127-130. Epub 2020 Mar 31.

School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Milano-Bicocca, Italy.

The artery of Percheron (AOP) is a single dominant thalamo-perforating artery that supplies bilaterally the medial thalami with variable contribution to the rostral midbrain. Occlusion of the AOP causes indeed variable and unspecific clinical symptoms due to this complex anatomy, and very often this diagnosis is delayed with the impossibility of recurring to intravenous thrombolysis (rTPA). Here, we report a case of AOP stroke that received a prompt diagnosis and therapy, owing to the availability of MR brain scan, showing a DWI/FLAIR mismatch typical of hyperacute infarctions. Read More

J Neurointerv Surg 2020 Apr 15. Epub 2020 Apr 15.

Interventional Neuroradiology Service, Department of Radiology, Beaumont Hospital, Dublin 9, Ireland.

Background And Purpose: Healthcare systems are challenged to provide access to thrombectomy in acute stroke patients. Either the "drip and ship" or "mothership" models result in increased numbers of patients in the endovascular stroke centre (ESC). We describe our approach for a "drip, ship, retrieve and leave" model repatriating patients immediately or within 24 hours of thrombectomy. Read More

Br J Neurosurg 2020 Apr 14:1-7. Epub 2020 Apr 14.

Neurosurgery Department, Hospital de Braga, Braga, Portugal.

Brainstem Cavernoma (BSCM) haemorrhage is a complex condition, especially when patients present rapid neurological deterioration. Traditionally, these patients were initially treated by non-interventional means. Surgery was generally reserved for cases who presented a 'benign' evolution in a subacute/delayed fashion. Read More

J Clin Med 2020 Apr 8;9(4). Epub 2020 Apr 8.

Experimental Radiology, Department of Radiology and Nuclear Medicine, Otto von Guericke University, 39120 Magdeburg, Germany.

Objective: Severely injured patients frequently develop an immunological imbalance following the traumatic insult, which might result in infectious complications evoked by a persisting immunosuppression. Regulatory T cells (Tregs) maintain the immune homeostasis by suppressing proinflammatory responses, however, their functionality after trauma is unclear. Here, we characterized the role of Tregs in regulating the proliferation of CD4 lymphocytes in traumatized patients (TP). Read More

Neurol Sci 2020 May 9;41(5):1003-1005. Epub 2020 Apr 9.

Neuroradiology Unit, Padua University Hospital, Padua, Italy.

Since the outbreak of the COVID-19 epidemic which in our region, Veneto (Italy), dates back to February, we were confronted with several challenges, but with a constant aim of keeping our Stroke Unit COVID-free. For this reason, in addition to creating a dedicated hot-spot as a pre-triage just outside the Emergency Department, together with the Neuroradiology Unit we obtained a mobile CT unit that could be used by COVID-positive or COVID-suspected patients. Furthermore, thanks to the collaboration with colleagues from different specialties (Infectious Disease, Internal Medicine, Intensive Care, Emergency Medicine), dedicated areas for COVID patients were activated. Read More

J Neurointerv Surg 2020 Apr 6. Epub 2020 Apr 6.

Diagnostic Imaging, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada

Background: The benefit of endovascular treatment (EVT) is highly time-dependent, and treatment delays reduce patients' chances to achieve a good outcome. In this survey-based study, we aimed to evaluate current in-hospital EVT workflow characteristics across different countries and hospital settings, and to quantify the time-savings that could be achieved by optimizing particular workflow steps.

Methods: In a multinational survey, neurointerventionalists were asked to provide specific information about EVT workflows in their current working environment. Read More

Resuscitation 2020 05 28;150:113-120. Epub 2020 Mar 28.

Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet, Sweden.

Background: Survival after out-of-hospital cardiac arrest remains poor. Levosimendan could be a new intervention in this setting. Therefore, we conducted a blinded, placebo controlled randomized study investigating the effects of levosimendan on survival and cardiac performance in an ischemic cardiac arrest model in swine. Read More

World Neurosurg 2020 Jun 27;138:349-351. Epub 2020 Mar 27.

Division of Interventional Neuroradiology, Department of Radiology, Hematology and Oncology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Background: Intracranial arteriovenous malformations (AVMs) have been considered congenital. We present and discuss a case of a child who had no evidence of an AVM at 6 years of age when presenting with parenchymatous hemorrhage due to cavernous angioma and who developed the lesion during 10 years of follow-up.

Case Description: A 6-year-old female presented with parenchymatous hemorrhage and was diagnosed with cavernous angioma of the right occipital lobe. Read More

Singapore Med J 2020 Mar 31. Epub 2020 Mar 31.

Department of Neuroradiology, National Neuroscience Institute, Singapore

Introduction: Stroke is a leading cause of death and disability, with the administration of reverse transcriptase-plasminogen activator (rtPA) improving outcomes in a time-dependent manner. Only 52.3% of our eligible stroke patients received rtPA within 60 minutes of arrival. Read More

Sci Rep 2020 Mar 27;10(1):5655. Epub 2020 Mar 27.

Department of Neurology, Dresden Neurovascular Center, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.

Stroke networks facilitate access to endovascular treatment (EVT) for patients with ischemic stroke due to large vessel occlusion. In this study we aimed to determine the safety of inter-hospital transfer and included all patients with acute ischemic stroke who were transferred within our stroke network for evaluation of EVT between 06/2016 and 12/2018. Data were derived from our prospective EVT database and transfer protocols. Read More

Neurol Sci 2020 Mar 25. Epub 2020 Mar 25.

Stroke Unit, University of Perugia - Santa Maria della Misericordia Hospital, Perugia, Italy.

Introduction: Hematoma expansion (HE) after intracerebral hemorrhage (ICH) is associated with short-term mortality, but its impact on long-term prognosis is still unclear. The aim of this study was to evaluate the impact of HE on long-term survival and functional status after spontaneous ICH.

Methods: Consecutive patients admitted with spontaneous ICH were prospectively enrolled and followed up for a minimum of 2 years. Read More

Neurol Genet 2020 Apr 20;6(2):e399. Epub 2020 Feb 20.

Department of Neuromuscular Diseases (V.C., S.E., L.S., J.V., V.S., N.W.W., H.H.), UCL Queen Square Institute of Neurology; National Hospital for Neurology and Neurosurgery (V.C., S.E., L.S., J.V., V.S., N.W.W., H.H.), Queen Square, London, UK; Department of Neurology and Neurosurgery (V.C., S.G.), Institute of Emergency Medicine, Chisinau, Republic of Moldova; Department of Neuroscience (M.C.), University of Padua, Italy; Northern Ireland Regional Genetics Service (G.R., P.J.M.), Belfast City Hospital, UK; Department of Neuroscience (A.B.), Interdisciplinary Center (IDC) Herzliya, Israel; Department of Paediatrics & Child Health (S.K., F.J., S.I., F.K., Z.Q.), Aga Khan University, Karachi, Pakistan; Department of Neurology (L.M.), Eastern Piedmont University, Novara, Italy; Department of Neurology (E.S., D.P.) and Department of Neuroradiology (L.C.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; Department of Clinical Neurology (N.B.), University of Nottingham, UK; Department of Clinical and Movement Neurosciences (B.B., K.P.B., N.W.W.), UCL Queen Square Institute of Neurology, London, UK; Department of Neurology (B.B.), Heidelberg University Hospital, Germany; Reta Lila Weston Institute (A.L.), UCL Queen Square Institute of Neurology, London, UK; and Medical Genetics and Neurogenetics Unit (B.G.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Objective: To identify the phenotypic, neuroimaging, and genotype-phenotype expression of mutations.

Methods: Using next-generation sequencing, we screened 86 patients with primary familial brain calcification (PFBC) from 60 families with autosomal recessive or absent family history that were negative for mutations in , , , and . In-depth phenotyping and neuroimaging investigations were performed in all cases reported here. Read More

BMC Neurol 2020 Mar 24;20(1):108. Epub 2020 Mar 24.

Department of Clinical Radiology and Neuroradiology, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Muenster, Germany.

Background: In the emergency setting of acute ischemic stroke, seizures have been reported in up to 4% of patients. In the absence of arterial occlusion, seizures may also cause abnormalities in CT perfusion in 78% of cases when the time window from onset to imaging is short. Both hyperperfusion and hypoperfusion in the postictal state have been described. Read More