358,708 results match your criteria Emergency Medicine News [Journal]


Health Information Exchange in Emergency Medical Services.

Appl Clin Inform 2018 Oct 12;9(4):884-891. Epub 2018 Dec 12.

The Warren Alpert Medical School, Brown University, Providence, Rhode Island, United States.

Background:  The Office of the National Coordinator for Health Information Technology has outlined the benefits of health information exchange in emergency medical services (EMSs) according to the model-, , , -developed in collaboration with the California Emergency Medical Services Authority.

Objective:  This scoping review aims to identify and characterize progress toward the adoption of prehospital health information exchange, as reported in the peer-reviewed literature.

Methods:  A structured review of literature in MEDLINE-indexed journals was conducted using the "Electronic Health Records" topic-specific query, the "Emergency Medical Services" Medical Subject Headings descriptor, and a prehospital identifier. Read More

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October 2018
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Loss of Transfected Human Brain Micro-Vascular Endothelial Cell Integrity during Herpes Simplex Virus Infection.

Intervirology 2018 Dec 12:1-11. Epub 2018 Dec 12.

Faculty of Medicine and Biomedical Sciences, MAHSA University, Saujana Putra Campus, Jenjarum,

Objective: Herpes simplex virus infection through the neuronal route is the most well-studied mode of viral encephalitis that can persists in a human host for a lifetime. However, the involvement of other possible infection mechanisms by the virus remains underexplored. Therefore, this study aims to determine the temporal effects and mechanisms by which the virus breaches the human brain micro-vascular endothelial cells of the blood-brain barrier. Read More

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December 2018

Impaired Consciousness in the Emergency Department.

Eur Neurol 2018 Dec 12;80(3-4):179-186. Epub 2018 Dec 12.

Department of Neurology, Hospital of the Ludwig-Maximilians-University (LMU), Munich,

Background: The approach to unconscious patients in the emergency department (ED) is difficult, often depends on local resources and interests, and workup strategies often lack standardization. One reason for this is that data on causes, management, and outcome of patients who present to the ED with sudden onset unconsciousness of unknown cause is limited.

Objectives: This study was performed to analyze the causes of acute impaired consciousness in patients in an interdisciplinary ED. Read More

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December 2018
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Influence of Nutritional Management and Rehabilitation on Physical Outcome in Japanese Intensive Care Unit Patients: A Multicenter Observational Study.

Ann Nutr Metab 2018 Dec 12;74(1):35-43. Epub 2018 Dec 12.

Emergency and Critical Care Medicine, Tokushima University Graduate School, Tokushima, Japan.

Background: There is lack of evidence regarding nutritional management among intensive care unit (ICU) patients in a population with relatively low body mass index. Therefore, we conducted an observational study to assess the nutritional management in Japanese ICUs. Also, we investigated the impact of nutritional management and rehabilitation on physical outcome. Read More

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December 2018

Surgical outcomes of renal transplant recipients after abdominal surgery not connected with transplantation A retrospective case-control study.

Int J Surg 2018 Dec 9. Epub 2018 Dec 9.

Department for General and Visceral Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Background: Due to the increasing number of patients after kidney transplantation, elective and emergency surgery of transplanted patients is becoming a relevant challenge in clinical routine. The current data on complication rate of patients after kidney transplantation, which must undergo another elective or emergency abdominal surgery, is inhomogeneous. Therefore, the aim of our study was to evaluate the outcome of renal transplant patients undergoing abdominal and abdominal wall surgery. Read More

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December 2018

The impact of Australian healthcare reforms on emergency department time-based process outcomes: An interrupted time series study.

PLoS One 2018 12;13(12):e0209043. Epub 2018 Dec 12.

Centre for Health Policy, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Background: In 2011, the Australian government introduced national healthcare reforms aimed at increasing the timeliness and quality of hospital care. The healthcare reforms included, but were not limited to, emergency department (ED) time-based targets, financial incentives, and public performance reporting of hospital data. We sought to evaluate the impact of the national healthcare reforms on ED time-based process outcomes. Read More

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December 2018

Patients who leave Emergency Department without being seen or during treatment in the Lazio Region (Central Italy): Determinants and short term outcomes.

PLoS One 2018 12;13(12):e0208914. Epub 2018 Dec 12.

Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.

Background And Aims: Patients who leave Emergency Department before physician's visit (LWBS) or during treatment (LDT) represent a useful indicator of the emergency care's quality. The profile of patients LWBS was described: they are generally males, young, with lower urgency triage allocation and longer waiting time. They have a greater risk of ED re-admission compared to discharged patients, but effect on hospitalization and mortality are more controversial. Read More

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December 2018

Can patients be trained to expect shared decision making in clinical consultations? Feasibility study of a public library program to raise patient awareness.

PLoS One 2018 12;13(12):e0208449. Epub 2018 Dec 12.

Tier 1 Canada Research Chair in Shared Decision Making and Knowledge Translation, Université Laval, Quebec City (QC, Canada).

Introduction: Shared decision making (SDM) is a process whereby decisions are made together by patients and/or families and clinicians. Nevertheless, few patients are aware of its proven benefits. This study investigated the feasibility, acceptability and impact of an intervention to raise public awareness of SDM in public libraries. Read More

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December 2018

Usefulness of C-MAC video laryngoscope in direct laryngoscopy training in the emergency department: A propensity score matching analysis.

PLoS One 2018 12;13(12):e0208077. Epub 2018 Dec 12.

Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objectives: We determined the usefulness of C-MAC video laryngoscope (C-MAC) as a safe training tool for the direct laryngoscopy technique in the emergency department.

Methods: We retrospectively analyzed an institutional airway registry of adult (≥18 years old) patients from April 2014 through October 2016. In this study, the operator used C-MAC as a direct laryngoscope (DL) with limited access to the screen, and the supervisor instructed the operator via verbal feedback while watching the screen. Read More

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December 2018

Risk factors for ectopic pregnancy in a population of Cameroonian women: A case-control study.

PLoS One 2018 12;13(12):e0207699. Epub 2018 Dec 12.

Department of Obstetrics and Gynaecology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Objective: To identify the risk factors for ectopic pregnancy (EP) in a population of Cameroonian women.

Sample And Methods: We performed a matched case-control study; 88 women with diagnosed EP (cases), and 176 women with first trimester intrauterine pregnancy (IUP) (controls), who underwent questionnaires. Odds Ratio (OR) and 95% confidence intervals (CIs) were calculated and adjusted for potential confounding factors via multivariate logistic regression analysis. Read More

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December 2018

Point-of-care lung ultrasound for the detection of pulmonary manifestations of malaria and sepsis: An observational study.

PLoS One 2018 12;13(12):e0204832. Epub 2018 Dec 12.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Introduction: Patients with severe malaria or sepsis are at risk of developing life-threatening acute respiratory distress syndrome (ARDS). The objective of this study was to evaluate point-of-care lung ultrasound as a novel tool to determine the prevalence and early signs of ARDS in a resource-limited setting among patients with severe malaria or sepsis.

Materials And Methods: Serial point-of-care lung ultrasound studies were performed on four consecutive days in a planned sub study of an observational cohort of patients with malaria or sepsis in Bangladesh. Read More

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December 2018

Antibiotic prescribing practices in secondary and tertiary hospitals in Shaanxi province, western China, 2013-2015.

PLoS One 2018 12;13(12):e0207229. Epub 2018 Dec 12.

Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.

Introduction: The irrational use of antibiotics is a major driver of antimicrobial resistance. This study aimed to explore how antibiotics were used in secondary and tertiary hospitals in Shaanxi Province, western China from 2013 to 2015.

Method: A retrospective study was conducted with a sample of 16 hospitals in Shaanxi Province (2 tertiary and 14 secondary hospitals; 8 public and 8 private hospitals) using a stratified random sampling method. Read More

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December 2018

[Peritonitis treated by laparoscopy as an effective treatment].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):261-264

Universidad Cooperativa de Colombia. Pasto, Nariño, Colombia.

Peritonitis is one of the main complications of abdominal emergencies. Laparoscopy serves both for the diagnostic and therapeutic management of the acute abdomen; in expert hands the morbimortality of this method is minimal.

Objective: The objective is to verify the efficacy of laparoscopy in patients with secondary peritonitis performing a single surgery without the need for reinterventions, ensuring the least damage of the abdominal wall, avoiding laparotomy. Read More

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December 2018
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Antiemetic Drug Use in Children: What the Clinician Needs to Know.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Clinical Pharmacology & Digestive Pathophysiology Unit, Department of Clinical & Experimental Medicine, University of Parma, Parma, Italy.

Vomiting is not only unpleasant for both children and families, but can lead to frequent hospital admission. The persistent vomiting hampers oral intake and increases the risk of dehydration so the proper use of antiemetic drugs can be useful. The pharmacological treatment of vomiting in children remains a challenge for the pediatrician because several antiemetics are prescribed as "off-label", outside their authorized drug label. Read More

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December 2018

Atorvastatin improves doxorubicin-induced cardiac dysfunction by modulating Hsp70, Akt and MAPK signalling pathways.

J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, The Second Hospital of Shandong University, Jinan, China.

Atorvastatin is a lipid-regulating drug that is commonly used in clinical practice and can stabilize plaques. Increasing evidence shows that statins have anti-heart failure effects, but their specific mechanism is not clear. The purpose of this study was to investigate the cardioprotective effects of atorvastatin on heart failure in rats and its mechanism. Read More

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December 2018
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Development and Usability Testing of the Society for Pediatric Anesthesia Pedi Crisis Mobile Application.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

United States National Aeronautics and Space Administration, Ames Research Center, Moffett Field, California.

When life-threatening, critical events occur in the operating room, the fast-paced, high-distraction atmosphere often leaves little time to think or deliberate about management options. Success depends on applying a team approach to quickly implement well-rehearsed, systematic, evidence-based assessment and treatment protocols. Mobile devices offer resources for readily accessible, easily updatable information that can be invaluable during perioperative critical events. Read More

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December 2018

VALIDITY AND RELIABILITY OF A NEW TRIAGE SYSTEM FOR PEDIATRIC EMERGENCY CARE: CLARIPED.

Rev Paul Pediatr 2018 Oct-Dec;36(4):398-406

Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

Objective: To assess the validity and reliability of a triage system for pediatric emergency care (CLARIPED) developed in Brazil.

Methods: Validity phase: prospective observational study with children aged 0 to 15 years who consecutively visited the pediatric emergency department (ED) of a tertiary hospital from July 2 to 18, 2013. We evaluated the association of urgency levels with clinical outcomes (resource utilization, ED admission rate, hospitalization rate, and ED length of stay); and compared the CLARIPED performance to a reference standard. Read More

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VALIDATION OF SCREENING SYSTEMS IN PEDIATRIC EMERGENCY.

Rev Paul Pediatr 2018 Oct-Dec;36(4):386-387

Universidade Estadual de Campinas, Campinas, SP, Brasil.

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ASSOCIATION OF PROMOTER REGION POLYMORPHISMS OF INTERLEUKIN-10 GENE WITH SUSCEPTIBILITY TO COLORECTAL CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Arq Gastroenterol 2018 Jul-Sep;55(3):306-313

Shahid Sadoughi University of Medical Sciences, Department of Medical Genetics, Yazd, Iran.

Background: Several epidemiological studies have investigated the association of promoter region polymorphisms of Interleukin-10 (IL-10) gene with colorectal cancer (CRC), while the conclusion is still conflicting and inconclusive.

Objective: We conducted this meta-analysis to evaluate the association of promoter region polymorphisms of IL-10 with CRC.

Methods: Eligible articles were identified by a search of several bibliographic databases for the period up to March 15, 2018. Read More

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Construction and validation of a distance Basic Life Support Course.

Rev Bras Enferm 2018 ;71(suppl 6):2698-2705

Universidade Federal do Rio Grande do Norte. Natal, Rio Grande do Norte, Brazil.

Objective: to describe the content construction and validation process of the Distance Education Basic Life Support Course.

Method: methodological study, developed through literature review, outlined in the light of the Bloom's Taxonomy and Ausubel's Meaningful Learning Theory. For validation, the analysis was performed with judges, using a structured tool. Read More

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January 2018

Brazilian guidelines for the management of psychomotor agitation. Part 1. Non-pharmacological approach.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

Comissão de Emergências Psiquiátricas, Associação Brasileira de Psiquiatria (ABP), Rio de Janeiro, RJ, Brazil.

Objective: To present the essential guidelines for non-pharmacological management of patients with psychomotor agitation in Brazil.

Methods: These guidelines were developed based on a systematic review of articles published from 1997 to 2017, retrieved from MEDLINE (PubMed), Cochrane Database of Systematic Review, and SciELO. Other relevant articles identified by searching the reference lists of included studies were also used to develop these guidelines. Read More

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December 2018

A review on Noncommunicable Diseases (NCDs) burden, its socio-economic impact and the strategies for prevention and control of NCDs in India.

Indian J Public Health 2018 Oct-Dec;62(4):302-304

Assistant Professor, Department of Bio-Technology, Techno India University, West Bengal, India.

Noncommunicable diseases (NCDs) have become a major public health problem in India accounting for 62% of the total burden of foregone DALYs and 53% of total deaths. Out-of-pocket expenditure associated with the acute and long-term effects of NCDs is high resulting in catastrophic health expenditure for the households. A large national survey in India found that spending on NCDs accounted for 5. Read More

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December 2018

Severe hypercalcemia: A rare and unusual presentation of acute lymphoblastic leukemia.

J Cancer Res Ther 2018 Dec;14(Supplement):S1244-S1246

Division of Pediatric Hemato Oncology, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.

Hypercalcemia is a rare and unusual complication of childhood malignancies. Acute lymphoblastic leukemia (ALL) presenting with hypercalcemia and lytic bone lesions is very rare in children. Here, we report a case of a 4-year-old girl with ALL who presented with severe hypercalcemia and radiological evidence of osteolytic lesions. Read More

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December 2018
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Impact of Relative Blood Glucose Changes on Mortality Risk of Patient with Acute Ischemic Stroke and Treated with Mechanical Thrombectomy.

J Stroke Cerebrovasc Dis 2019 Jan 24;28(1):213-219. Epub 2018 Oct 24.

Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. Electronic address:

Background And Purpose: The impacts of stress hyperglycemia and hypoglycemia on mortality of acute ischemic stroke patients treated with mechanical thrombectomy (MT) are largely unclear. This study aimed to use stress hyperglycemia ratio (SHR) to evaluate the influence of pretreatment relative blood glucose changes on mortality risk after MT.

Methods: The study retrospectively enrolled 321 acute ischemic stroke patients treated with MT. Read More

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January 2019

In Brief.

Curr Probl Surg 2018 Jul 6;55(7):252-254. Epub 2018 Sep 6.

Professor of Surgery, Emergency Medicine, and Anesthesia Medical Director, Surgical Intensive Care Unit Associate Trauma Medical Director University of Southern California, Los Angeles, CA. Electronic address:

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July 2018
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Using intracameral vital dye as a guide for venting incision in acute corneal hydrops.

Eur J Ophthalmol 2018 Dec 12:1120672118818012. Epub 2018 Dec 12.

Ocular Trauma and Emergency Department and Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose:: To introduce a new surgical technique for the localization of corneal bulla to drain a massive corneal hydrops.

Methods:: Four consecutive cases with acute large protruded hydrops were selected. A limbal paracentesis was made via 15° blade. Read More

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December 2018
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Pediatric open-globe injury in a university-based tertiary hospital.

Eur J Ophthalmol 2018 Dec 12:1120672118818013. Epub 2018 Dec 12.

1 Department of Ophthalmology, King Abdulaziz University Hospital, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background:: To investigate epidemiology, etiology, and outcomes after repair of pediatric open-globe injury.

Methods:: We retrospectively reviewed medical records of patients ⩽18 years who underwent primary open-globe repair.

Results:: A total of 213 patients were identified. Read More

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December 2018

The impact of obesity as an independent risk factor for the development of renal injury: implications from rat models of obesity.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

Pharmacology and Toxicology, University of Mississippi Medical Center, United States.

Diabetes and hypertension are the major causes of chronic kidney disease (CKD). Epidemiological studies within the last few decades have revealed that obesity-associated renal disease is a emerging epidemic and that the increasing prevalence of obesity parallels the increased rate of CKD. This has led to the inclusion of obesity as an independent risk factor for CKD. Read More

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December 2018

Disaster Prevention and Recovery.

Methods Mol Biol 2019 ;1897:31-41

Tissue Repository, National University Hospital, National University Health System, Singapore, Singapore.

Biobanking is a costly activity that manages valuable and sometimes irreplaceable specimens. These specimens must be managed and protected carefully as the loss of specimens can destroy years of research efforts, and potentially result in reputational damage to the institution. Therefore, risk management, mitigation, and disaster recovery plans must be in place for unexpected man-made or natural disaster events that will affect biobanking operations. Read More

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January 2019

A Review on Ingested Cyanide: Risks, Clinical Presentation, Diagnostics, and Treatment Challenges.

J Med Toxicol 2018 Dec 11. Epub 2018 Dec 11.

Department of Emergency Medicine and Toxicology, University of Colorado School of Medicine, 12700 E. 19th Ave., Aurora, CO, 80045, USA.

Cyanide, a metabolic poison, is a rising chemial threat and ingestion is the most common route of exposure. Terrorist organizations have threatened to attack the USA and international food and water supplies. The toxicokinetics and toxicodynamics of oral cyanide are unique, resulting in high-dose exposures, severe symptoms, and slower onset of symptoms. Read More

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December 2018

Inflammatory arthritis: a unique presentation of human anaplasmosis.

Clin Rheumatol 2018 Dec 11. Epub 2018 Dec 11.

Rheumatology Department at Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Hempstead, NY, USA.

Human granulocytic anaplasmosis (HGA) is a tickborne rickettsial disease caused by the bacterium Anaplasma phagocytophilum. Reported cases have increased with the highest incidence in the Northeast. To our knowledge, this is the first report of anaplasmosis associated with an inflammatory arthritis. Read More

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December 2018

Evaluation of the adherence of distress screening with the distress thermometer in cancer patients 4 years after implementation.

Support Care Cancer 2018 Dec 11. Epub 2018 Dec 11.

PhD Program, Department of Nursing Science, University Witten/Herdecke, Witten, Germany.

Purpose: Identifying and assessing psychosocial distress with an appropriate screening instrument is essential when caring for cancer patients. Since 2012, the distress thermometer (DT) has been used by nurses for all cancer inpatients at the Comprehensive Cancer Center Zurich. We wanted to identify nurses' adherence to the screening protocol, differences between screened and not screened patients and the relationship between screening rate and productivity. Read More

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December 2018

A summer wave of vertebral fractures: the "deck-slap" injury.

Acta Neurochir (Wien) 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurosurgery, Sainte-Anne Military Hospital, BP 600, 83800, Toulon Cedex 09, France.

Background: Every summer, several patients who suffer from vertebral fractures are hospitalized at the Sainte-Anne Military Hospital after going on a boat trip around the French Riviera. The uniqueness of these fractures lies in their mechanism of injury, called the "deck-slap" injury. The aim of this study is to describe the characteristics of the "deck-slap" injury. Read More

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December 2018
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Comparison of trauma outcomes between Japan and the USA using national trauma registries.

Trauma Surg Acute Care Open 2018 5;3(1):e000247. Epub 2018 Nov 5.

Riverside University Health System Medical Center and Loma Linda University School of Medicine, Riverside, California, USA.

Background: The National Trauma Data Bank (NTDB) has served as a global benchmark for trauma care quality and outcomes. Herein, we compared patient characteristics, trauma management, and outcomes between Japanese emergency and critical care centers and US level 1 trauma centers using the Japanese Trauma Data Bank (JTDB) and NTDB.

Methods: A retrospective cohort matching (1:1) study was performed. Read More

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November 2018

Analyses of clinical outcomes after severe pelvic fractures: an international study.

Trauma Surg Acute Care Open 2018 21;3(1):e000238. Epub 2018 Nov 21.

Riverside University Health System Medical Center and Loma Linda University School of Medicine, Riverside, California, USA.

Background: This study aimed to compare treatment outcomes between patients with severe pelvic fractures treated at a representative trauma center that was established in Korea since 2015 and matched cases treated in the USA.

Methods: Two cohorts were selected from a single institution trauma database in South Korea (Ajou Trauma Data Bank (ATDB)) and the National Trauma Data Bank (NTDB) in the USA. Adult blunt trauma patients with a pelvic Abbreviated Injury Scale >3 were included. Read More

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November 2018
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Crisis on the game board - a novel approach to teach medical students about disaster medicine.

GMS J Med Educ 2018 15;35(4):Doc46. Epub 2018 Nov 15.

McGill University, Department of Political Science, Montreal, Canada.

Every year, natural and other disasters cause significant loss of life around the world. This calls for an improved response from, among others, the health professions to strengthen disaster medicine, whether relating to prevention, emergency response or recovery. It includes both knowledge and competencies, such as planning, coordination, and communication. Read More

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November 2018

Development, implementation and first insights of a time- and location-independent longitudinal postgraduate curriculum in emergency medicine.

GMS J Med Educ 2018 15;35(4):Doc44. Epub 2018 Nov 15.

University of Bern, Bern University Hospital, Inselspital, Department of Emergency Medicine, Bern, Switzerland.

There have been few reports on the implementation of a structured curriculum for emergency medicine, as emergency medicine is not yet an established medical specialty for training in many European countries, including Switzerland and Germany. Because of the non-plannable workload in the emergency setting, common training approaches are often difficult to implement. Need-assessments of emergency medicine trainees commonly identify a need for interactive, time-independent ways of learning that integrate modern forms of knowledge transfer. Read More

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November 2018

Endoscopic suturing for management of peptic ulcer-related upper gastrointestinal bleeding: a preliminary experience.

Endosc Int Open 2018 Dec 10;6(12):E1439-E1444. Epub 2018 Dec 10.

Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.

Acute non-variceal upper gastrointestinal bleeding (UGIB) due to peptic ulcer disease (PUD) remains a common and challenging emergency managed by gastroenterologists. The proper role of endoscopic suturing on the management of PUD-related UGIB is unknown.  This is an international case series of patients who underwent endoscopic suturing for bleeding PUD. Read More

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December 2018

Antimicrobial Susceptibility Trends Observed in Urinary Pathogens Obtained From New York State.

Open Forum Infect Dis 2018 Nov 16;5(11):ofy297. Epub 2018 Nov 16.

Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York.

International guidelines recommend using local susceptibility data to direct empiric therapy for acute uncomplicated cystitis. We evaluated outpatient urinary isolate susceptibility trends in New York State. Nitrofurantoin had the lowest resistance prevalence whereas trimethoprim-sulfamethoxazole and fluoroquinolones had higher prevalences. Read More

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November 2018

Effectiveness of the Oral Human Attenuated Rotavirus Vaccine: A Systematic Review and Meta-analysis-2006-2016.

Open Forum Infect Dis 2018 Nov 12;5(11):ofy292. Epub 2018 Nov 12.

GSK, Wavre, Belgium.

Background: Gastroenteritis caused by rotavirus accounts for considerable morbidity in young children. We aimed to assess the vaccine effectiveness (VE) of the oral rotavirus vaccine , as measured by laboratory-confirmed rotavirus infection after referral to hospital and/or emergency departments in children aged <5 years with gastroenteritis.

Methods: We performed a systematic search for peer-reviewed studies conducted in real-life settings published between 2006 and 2016 and a meta-analysis to calculate the overall VE, which was further discriminated through stratified analyses. Read More

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November 2018

Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak.

Open Forum Infect Dis 2018 Nov 25;5(11):ofy276. Epub 2018 Oct 25.

National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy.

Chikungunya fever is caused by Chikungunya virus (CHIKV) and is generally considered a self-limiting disease. However, severe clinical presentations with a high mortality rate have been reported in association with underlying medical conditions. This study reports the molecular characterization of the virus and an abnormal pattern of circulating cytokines in a unique lethal CHIKV case during the 2017 outbreak in Italy, which involved an elderly patient with underlying cardiac disease. Read More

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November 2018
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Mediators of Inflammation - A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma.

J Immunol Res 2018 12;2018:1061780. Epub 2018 Nov 12.

"Victor Babes" Clinical Hospital for Infectious Diseases, 281 Mihai Bravu, 030303 Bucharest, Romania.

Oral squamous cell carcinoma (OSCC) is the most common tumour of the oral cavity, associated with significant morbidity and mortality. It is a multifactorial condition, both genetic and environmental factors being involved in its development and progression. Its pathogenesis is not fully elucidated, but a pivotal role has been attributed to inflammation, strong evidence supporting the association between chronic inflammation and carcinogenesis. Read More

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November 2018

Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications.

J Diabetes Res 2018 12;2018:5205126. Epub 2018 Nov 12.

Department of Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

The prevalence of diabetes is steadily rising, and once it occurs, it can cause multiple complications with a negative impact on the whole organism. Complications of diabetes may be macrovascular: such as stroke and ischemic heart disease as well as peripheral vascular and microvascular diseases-retinopathy, nephropathy, and neuropathy. Key factors that cause cardiovascular disease in people with diabetes include hyperglycemia, dyslipidemia, obesity, insulin resistance, inflammation, hypertension, autonomic dysfunction, and decreased vascular response capacity. Read More

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November 2018

Encapsulating Peritoneal Sclerosis in Long-Termed Peritoneal Dialysis Patients.

Biomed Res Int 2018 13;2018:8250589. Epub 2018 Nov 13.

Division of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.

Background: Encapsulating peritoneal sclerosis (EPS) is a rare but serious clinical complication of long-term peritoneal dialysis (PD) patients with high mortality. The purpose of this study was to assess the clinical characteristics of patients with EPS and to search for possible factors useful for EPS prevention and early diagnosis.

Method: This retrospective study was performed in a single dialysis center in Taiwan between August 1990 and April 2014. Read More

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November 2018

Prognostic Significance of Platelet-to-Lymphocyte Ratio in Cholangiocarcinoma: A Meta-Analysis.

Biomed Res Int 2018 14;2018:7375169. Epub 2018 Nov 14.

Department of Emergency Surgery, The First Affiliated Hospital of Nanchang University, No. 17 Yongwai Street, Nanchang, Jiangxi Province 330006, China.

Introduction: Pretreatment platelet-to-lymphocyte ratio (PLR) has been considered a prognostic factor in various cancers. However, the application of PLR in the assessment of patients with cholangiocarcinoma remains controversial. This study aimed to evaluate the prognostic value of pretreatment PLR in cholangiocarcinoma. Read More

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November 2018

"Feelings and Fitness" Not "Feelings or Fitness"-The of Conservation Welfare, Which Aligns Conservation and Animal Welfare Objectives.

Front Vet Sci 2018 27;5:296. Epub 2018 Nov 27.

Royal New Zealand Society for the Prevention of Cruelty to Animals, Auckland, New Zealand.

Increasingly, human activities, including those aimed at conserving species and ecosystems (conservation activities) influence not only the survival and fitness but also the welfare of wild animals. Animal welfare relates to how an animal is experiencing its life and encompasses both its physical and mental states. While conservation biology and animal welfare science are both multi-disciplinary fields that use scientific methods to address concerns about animals, their focus and objectives sometimes appear to conflict. Read More

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November 2018

Zinc toxicosis in a dog secondary to prolonged zinc oxide ingestion.

Authors:
Jia Wen Siow

Open Vet J 2018 25;8(4):458-462. Epub 2018 Nov 25.

AEC Adelaide, 102 Magill Road, Norwood South Australia 5067, Australia.

Zinc toxicosis is commonly associated with ingestion of metallic zinc objects. This report documents an uncommon presentation of zinc toxicosis, secondary to prolonged ingestion of a zinc oxide cream. A 5. Read More

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November 2018

Orbital compartment syndrome resulting in unilateral blindness in two dogs.

Open Vet J 2018 22;8(4):445-451. Epub 2018 Nov 22.

Department of Clinical Sciences, Companion and Equine Animals, Ophthalmology, University of Liège, Quartier Vallée 2, Avenue de Cureghem 3, 4000 Liège, Belgium.

Orbital compartment syndrome (OCS) is described in humans as an acute rise in intraorbital pressure following a severe and rapidly evolving orbital affection. It includes orbital oedema, haemorrhage or infection causing a marked reduction in local blood perfusion, and severely affecting the orbital neurovascular structures. If not promptly recognised and treated, it results in irreversible blindness. Read More

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November 2018

A Case of Upper Limb Osteomyelitis and Septic Arthritis Presenting as Pseudoparalysis in a Two-Week-Old.

Case Rep Pediatr 2018 12;2018:1796831. Epub 2018 Nov 12.

Trauma and Orthopaedics Department, Cambridge University Hospitals Trust, Cambridge, UK.

Pseudoparalysis presenting in infants is a rare manifestation, where infection and trauma are the principle differentials. We present a case of a two-week-old baby boy with pseudoparalysis who was initially diagnosed as Erb's palsy when presented in the emergency department and later re-presented with signs of sepsis. A later diagnosis of osteomyelitis of the humerus and septic arthritis of the shoulder was made. Read More

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November 2018