21,379 results match your criteria Embryonal Carcinoma


Embryonal life histories: Desiccation plasticity and diapause in the Argentinean pearlfish .

Ecol Evol 2018 Nov 30;8(22):11246-11260. Epub 2018 Oct 30.

Centre for Biodiversity Naturalis Leiden The Netherlands.

Embryos of annual killifish diapause in soil egg banks while ponds are dry. Their rates of development and survival in different developmental stages determine the numbers and stages of embryos at rewetting. In the Argentinean pearlfish , we investigated plasticity for desiccation in such embryonal life history components across phases of mild desiccation and rewetting and also effects of life history on hatching. Read More

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November 2018

Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.

J Cancer 2018 31;9(23):4440-4448. Epub 2018 Oct 31.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 in testicular germ cell tumors (TGCTs) is unclear at present. Read More

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October 2018

In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors.

Sci Rep 2018 Nov 30;8(1):17468. Epub 2018 Nov 30.

Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium.

Chemotherapy resistance is responsible for high mortality rates in neuroblastoma. MYCN, an oncogenic driver in neuroblastoma, controls pluripotency genes including LIN28B. We hypothesized that enhanced embryonic stem cell (ESC) gene regulatory programs could mark tumors with high pluripotency capacity and subsequently increased risk for therapy failure. Read More

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November 2018

Embryonal Origin of Metanephric Adenoma and its Differential Diagnosis.

Anticancer Res 2018 Dec;38(12):6663-6667

Department of Urology, Medical School, University of Pecs, Pecs, Hungary

Background/aim: The association of Wilms' tumor (WT), papillary renal cell tumor (PRCT) and mucinous tubular and spindle cell carcinoma (MTSCC) with embryonal rests has already been documented, but the cellular origin of metanephric adenoma (MA) is not yet known. The aim of this study was to understand their developmental evolution and find diagnostic markers.

Materials And Methods: CD57, KRT7, AMACR, SCEL, WT1 and CDH17 expression was analysed by immunohistochemistry in the four types of tumors and the associated pre-neoplastic lesions. Read More

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December 2018

The MicroRNA-371 Family as Plasma Biomarkers for Monitoring Undifferentiated and Potentially Malignant Human Pluripotent Stem Cells in Teratoma Assays.

Stem Cell Reports 2018 Nov 27. Epub 2018 Nov 27.

Department of Pathology, Laboratory for Experimental Patho-Oncology, Erasmus MC Cancer Institute, Be-432A, PO Box 2040, 3000 CA Rotterdam, the Netherlands. Electronic address:

Predicting developmental potency and risk of posttransplantation tumor formation by human pluripotent stem cells (hPSCs) and their derivatives largely rely on classical histological analysis of teratomas. Here, we investigated whether an assay based on microRNAs (miRNA) in blood plasma is able to detect potentially malignant elements. Several hPSCs and human malignant germ cell tumor (hGCT) lines were investigated in vitro and in vivo after mouse xenografting. Read More

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November 2018
1 Read

Combined management of perianal rhabdomyosarcoma with chemotherapy, radical surgery, and irradiation: A series of three consecutive children.

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Children's Hospital, Section of Pediatric Surgery, University of Helsinki, Finland.

Background And Aim: We describe a series of three successive patients with perianal rhabdomyosarcoma (PRMS) from 2014 to 2017 managed with combined chemotherapy, radical surgery, and radiotherapy.

Methods: Ethical consent was obtained. Data including tumor presentation, treatment, and survival was collected from hospital reports. Read More

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November 2018

The 3rd Intron of IRF8 Is a Cell-Type Specific Chromatin Priming Element during Mouse Embryonal Stem Cells Differentiation.

J Mol Biol 2018 Nov 28. Epub 2018 Nov 28.

Department of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel. Electronic address:

Interferon Regulatory Factor 8 (IRF8) is a nuclear transcription factor that plays a key role in the hierarchical differentiation of Hematopoietic Stem Cells toward monocyte/dendritic cell (DC) lineages. Therefore, its expression is mainly limited to bone marrow derived cells. The molecular mechanisms governing this cell-type restricted expression have been described. Read More

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November 2018

Childhood Medulloblastoma Revisited.

Top Magn Reson Imaging 2018 Dec;27(6):479-502

Section of Neuroimaging, St. Jude Children's Research Hospital, Memphis, TN.

Medulloblastoma is the most common malignant solid tumor in childhood and the most common embryonal neuroepithelial tumor of the central nervous system. Several morphological variants are recognized: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity. Recent advances in transcriptome and methylome profiling of these tumors led to a molecular classification that includes 4 major genetically defined groups. Read More

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December 2018
1 Read

Carbohydrate Targets for CAR T Cells in Solid Childhood Cancers.

Front Oncol 2018 12;8:513. Epub 2018 Nov 12.

Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.

Application of the CAR targeting strategy in solid tumors is challenged by the need for adequate target antigens. As a consequence of their tissue origin, embryonal cancers can aberrantly express membrane-anchored gangliosides. These are carbohydrate molecules consisting of a glycosphingolipid linked to sialic acids residues. Read More

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November 2018
2 Reads

Adrenal Cortical Neoplasm with Uncertain Malignant Potential Arising in the Heterotopic Adrenal Cortex in the Liver of a Patient with Beckwith-Wiedemann Syndrome: A Case RTeport.

J Pathol Transl Med 2018 Nov 26. Epub 2018 Nov 26.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Patients with Beckwith-Wiedemann syndrome (BWS) are predisposed to developing embryonal tumors, with hepatoblastoma being the most common type. Our patient showed hemihypertrophy, macroglossia, and paternal uniparental disomy in chromosome 11 and was diagnosed with BWS. When the patient was nine months old, a 2. Read More

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November 2018
3 Reads

CD147 Is a Novel Chemotherapy or Prevention Target in Melanoma.

J Investig Dermatol Symp Proc 2018 Dec;19(2):S91-S93

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

CD147, also named as BSG, was first identified from F9 embryonal carcinoma cells (Miyauchi et al., 1990) and the human BSG locus on chromosome 19p13.3 containing 10 exons (Belton et al. Read More

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December 2018
4 Reads

English Translation of M. Bérard: Tumeur Embryonnaire Du Muscle Strié. [Embryonal Tumor of Striated Muscle]. Lyon Med 1894; 77: 52.

Fetal Pediatr Pathol 2018 Nov 23:1-3. Epub 2018 Nov 23.

c Professor of Pathology, 4650 Sunset Boulevard #43, Children's Hospital of Los Angeles, CA, USA.

We have chosen to translate what we believe to be the first publication of a well-documented case of a young patient with embryonal rhabdomyosarcoma. The author, M. Léon Bérard, was a hospital fellow working in the department of M. Read More

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November 2018

Trends in pediatric central nervous system tumor incidence in the United States, 1998-2013.

Cancer Epidemiol Biomarkers Prev 2018 Nov 21. Epub 2018 Nov 21.

Division of Cancer Epidemiology and Genetics, National Cancer Institute.

Background: Brain and other central nervous system (CNS) cancers are the leading cause of US pediatric cancer mortality. Incidence trends can provide etiological insight. We report trends in incidence rates of pediatric malignant CNS cancers and pilocytic astrocytoma (non-malignant but historically registered) in the US. Read More

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November 2018
3 Reads

Persisting Embryonal Infundibular Recess Masquerading as a Nasal Mass.

Asian J Neurosurg 2018 Oct-Dec;13(4):1219-1221

Department of Neurosurgery, Aster Medcity, Kochi, Kerala, India.

Persisting embryonal infundibular recess (PEIR) is a rare anomaly of the development of the posterior pituitary wherein there is a defect in the third ventricular floor. Earlier reports have found PEIR descending only up to the sella. However, this is the first case of PEIR presenting as a pulsatile nasal mass. Read More

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November 2018
1 Read

Sellar Embryonal Tumor: A Case Report and Review of the Literature.

Asian J Neurosurg 2018 Oct-Dec;13(4):1197-1201

Department of Neurosurgery, Ankara University, Ankara, Turkey.

Primitive neuroectodermal tumors (PNETs) are aggressive, poorly differentiated tumors in children and young adults. However, the embryonal tumor group did not include the central nervous system (CNS) PNET title and ependymoblastoma subtitle in the 2016 World Health Organization CNS tumor classification. Here, we report the case of a 6-year-old boy with a sellar embryonal tumor and present a review of the related literature. Read More

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November 2018
2 Reads

Pannexin 1 inhibits rhabdomyosarcoma progression through a mechanism independent of its canonical channel function.

Oncogenesis 2018 Nov 21;7(11):89. Epub 2018 Nov 21.

Molecular Biomedicine Program, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.

Rhabdomyosarcoma (RMS) is an aggressive soft tissue sarcoma of childhood thought to arise from impaired differentiation of skeletal muscle progenitors. We have recently identified Pannexin 1 (PANX1) channels as a novel regulator of skeletal myogenesis. In the present study, we determined that PANX1 transcript and protein levels are down-regulated in embryonal (eRMS) and alveolar RMS (aRMS) patient-derived cell lines and primary tumor specimens as compared to differentiated skeletal muscle myoblasts and tissue, respectively. Read More

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November 2018
3 Reads

Intraarterial indocyanine green (ICG) fluorescence augmentation by marking embryonal resection areas in colorectal surgery: a feasibility study in a porcine model.

Minim Invasive Ther Allied Technol 2018 Nov 15:1-5. Epub 2018 Nov 15.

a Department of General, Visceral, and Transplantation Surgery, Hospital of the LMU Munich , Ludwig-Maximilians-University (LMU) , Munich , Germany.

Aim: In this pilot animal study we examined whether it is possible to visualize the embryonal resection layers by using intraarterial indocyanine green (ICG) staining when performing total mesorectal excision (TME) for carcinoma of the rectum.

Material And Methods: We injected ICG into the inferior mesenteric artery (AMI) of four swines to see whether the watershed area of the arterial supply zone can be sufficiently visualized by fluorescence imaging in order to mark the right dissection area along the fascia parietalis before and during resection.

Results: We observed a fluorescence signal in all the supplied areas of AMI but not in other parts of the abdominal cavity or other organs. Read More

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November 2018
3 Reads

Bioinformatics and Regression Analyses Manifest Tumor-Specific miRNA Expression Dynamics in Pediatric Embryonal Malignancies.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:5834-5837

Pediatric Central Nervous System (CNS) neoplasms are the second most prevalent tumors of childhood. Further on, prognosis of this type of neoplasms still remain poor and the comprehension of the etiology and pathogenesis of the disease still remains scarce. Several reports have identified microRNAs as significant molecules in the development of central nervous system tumors and propose that they might compose key molecules underlying oncogenesis. Read More

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July 2018
1 Read

DNA methylation profiling as a tool for testicular germ cell tumors subtyping.

Epigenomics 2018 Nov 12. Epub 2018 Nov 12.

Cancer Biology & Epigenetics Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.

Aim: Assess differential patterns of selected five genes' promoter methylation among testicular germ cell tumors (TGCT) subtypes.

Materials & Methods:  CRIPTO, HOXA9, MGMT, RASSF1A and SCGB3A1 promoter methylation levels were evaluated by quantitative methylation-specific PCR in 161 TGCT and 16 controls. Associations between clinicopathological parameters and promoter methylation levels were assessed, and receiver operating characteristics curve analysis was performed. Read More

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November 2018
9 Reads

Intracranial Ewing sarcoma with whole genome study.

Childs Nerv Syst 2018 Nov 7. Epub 2018 Nov 7.

Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Introduction: Ewing sarcoma (ES) as a primary intracranial tumor is very rare. Recently, CNS embryonal tumors with ES-like genomic change have been reported. Patients and methods We report a case of intracranial Ewing sarcoma in a 13-year-old girl who complained of headache and migraine. Read More

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November 2018
1 Read

Somatic Embryogenesis and Plant Regeneration From Primordial Shoot Explants of (L.) H. Karst. Somatic Trees.

Front Plant Sci 2018 24;9:1551. Epub 2018 Oct 24.

Natural Resources Institute Finland (Luke), Savonlinna, Finland.

The recalcitrance of adult conifer tissues has prevented vegetative propagation of trees with known and desired characteristics. Somatic embryogenesis (SE) initiation protocol, recently developed for white spruce (, Klimaszewska et al., 2011), was applied in order to examine the feasibility, frequency and timing of SE induction from primordial shoots (PS) of Norway spruce ). Read More

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October 2018

Malignant Spinal Cord Compression Syndrome as an Initial Presentation of Testicular Cancer.

Case Rep Oncol Med 2018 8;2018:5757434. Epub 2018 Oct 8.

Centro Universitario Contra el Cáncer, University Hospital "Dr. José Eleuterio González" and Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Malignant spinal cord compression syndrome (MSCCS) occurs in 2.5 to 5% of all oncological patients. In 20% of the cases, it is the initial manifestation. Read More

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October 2018
5 Reads

Polo-Like Kinase 4 (PLK4) Is Overexpressed in Central Nervous System Neuroblastoma (CNS-NB).

Bioengineering (Basel) 2018 Nov 4;5(4). Epub 2018 Nov 4.

Division of Pediatric Neurosurgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.

Neuroblastoma (NB) is the most common extracranial solid tumor in pediatrics, with rare occurrences of primary and metastatic tumors in the central nervous system (CNS). We previously reported the overexpression of the polo-like kinase 4 (PLK4) in embryonal brain tumors. PLK4 has also been found to be overexpressed in a variety of peripheral adult tumors and recently in peripheral NB. Read More

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November 2018
4 Reads

Laparoscopic Radical Trachelectomy for Embryonal Rhabdomyosarcoma of the Cervix in a 2-Year-Old Girl.

Obstet Gynecol 2018 Dec;132(6):1486-1490

Division of Gynecologic Oncology, Department of Surgery and Surgical Oncology, University Health Network, Princess Margaret Cancer Centre, the Department of Obstetrics and Gynecology, University of Toronto, and the Section of Pediatric Gynecology, Division of Endocrinology, the Division of Pediatric Urology, Department of Surgery, and the Division of Hematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Embryonal rhabdomyosarcoma of the cervix is a rare and aggressive malignancy that usually affects children and young adults.

Case: We describe a 2-year-old patient who presented with a mass protruding through the vaginal introitus. Preoperative investigations including vaginoscopy, hysteroscopy, magnetic resonance imaging, and biopsies confirmed embryonal rhabdomyosarcoma, botryoid subtype, arising from the cervix. Read More

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December 2018
5 Reads

Overexpression of the Pluripotent Stem Cell Marker Podocalyxin in Prostate Cancer.

Anticancer Res 2018 Nov;38(11):6361-6366

Department of Pathology, Wayne State University School of Medicine, Detroit, MI, U.S.A.

Background/aim: Podocalyxin, a member of the CD34 family of cell surface sialomucins, is overexpressed in human embryonal carcinoma cell lines, as well as in several cancer types, and is associated with poor prognosis. Podocalyxin variants are associated with an increased risk and aggressiveness of prostate cancer. Herein podocalyxin protein expression in prostate cancer was characterized. Read More

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November 2018
8 Reads

RHOA activity in expanding blastocysts is essential to regulate HIPPO-YAP signaling and to maintain the trophectoderm-specific gene expression program in a ROCK/actin filament-independent manner.

Mol Hum Reprod 2018 Nov 5. Epub 2018 Nov 5.

1Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA.

Study Question: What molecular signals are required to maintain the functional trophectoderm (TE) during blastocyst expansion of the late stage of preimplantation development?

Summary Answer: The activity of ras homology family member A (RHOA) GTPases is necessary to retain the expanded blastocyst cavity and also to sustain the gene expression program specific to TE.

What Is Known Already: At the early stages of preimplantation development, the precursor of the TE lineage is generated through the molecular signals that integrate RHOA, RHO-associated coiled-coil containing protein kinase (ROCK), the apicobasal cell polarity, and the HIPPO-Yes-associated protein (YAP) signaling pathway. By contrast, molecular mechanisms regulating the maintenance of the TE characteristics at the later stage, which is crucial for blastocyst hatching and implantation, are scarcely understood. Read More

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November 2018
3 Reads

A rare pure embryonal rhabdomyosarcoma of the urinary bladder in an adult successfully managed with neoadjuvant chemotherapy and surgery: a case report.

J Med Case Rep 2018 Nov 4;12(1):329. Epub 2018 Nov 4.

Department of Pathology, University Hospital Centre Hassan II, Fez, Morocco.

Background: Rhabdomyosarcoma of the urinary bladder in adults is an extremely rare malignant neoplasm that develops from the bladder wall.

Case Presentation: We report our experience of a rare case of rhabdomyosarcoma of the bladder in a 45-year-old Moroccan man who was successfully managed with neoadjuvant chemotherapy and surgical excision of the mass; he was disease free at 24-month follow up.

Conclusions: To the best of our knowledge, this is the first reported case of a rare embryonal rhabdomyosarcoma of the bladder that was managed with neoadjuvant chemotherapy and surgery. Read More

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November 2018
4 Reads

A case report of infantile cystic nephroblastoma.

Diagn Pathol 2018 Oct 27;13(1):84. Epub 2018 Oct 27.

Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan.

Background: Nephroblastoma (NB) is a malignant embryonal neoplasm derived from nephrogenic blastemal cells. NB usually forms a solid mass, but in extremely rare cases, it may show cystic changes.

Case Presentation: A six-month-old girl with persistent high fevers was found to have pyuria and bacteriuria. Read More

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October 2018
4 Reads

Oncolytic Virus-Mediated RAS Targeting in Rhabdomyosarcoma.

Mol Ther Oncolytics 2018 Dec 15;11:52-61. Epub 2018 Sep 15.

Department of Pathology, University of Washington, Seattle, WA 98195, USA.

Aberrant activation of the receptor tyrosine kinase-mediated RAS signaling cascade is the primary driver of embryonal rhabdomyosarcoma (ERMS), a pediatric cancer characterized by a block in myogenic differentiation. To investigate the cellular function of activated RAS signaling in regulating the growth and differentiation of ERMS cells, we genetically ablated activated oncogenes with high-efficiency genome-editing technology. Knockout of in CRISPR-inducible ERMS xenograft models resulted in near-complete tumor regression through a combination of cell death and myogenic differentiation. Read More

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December 2018
4 Reads

Polycystic Kidney-like Disease in a Red-ear Slider Turtle (Trachemys scripta elegans).

J Comp Pathol 2018 Oct 22;164:44-47. Epub 2018 Sep 22.

Universität Bern, Centre for Fish and Wildlife Health-FIWI, Department of Infectious Diseases and Pathobiology, Länggassstrasse 122, Bern, Switzerland.

A 14-year-old red-ear slider turtle (Trachemys scripta elegans) with no history of pre-existing clinical disease died and was referred for necropsy examination. Grossly, oesophageal prolapse, bilateral renal cysts and a paraduodenal cystic mass were detected. Tissues were processed routinely for histology and immunohistochemistry (IHC) with primary antibodies specific for Wilm's tumour suppressor gene-1 (WT-1), insulin, glucagon and pancytokeratins. Read More

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October 2018
10 Reads

CK7, inhibin, and p63 in testicular germ cell tumor: superior markers of Choriocarcinoma compared to β-hCG.

Hum Pathol 2018 Oct 22. Epub 2018 Oct 22.

Department of Pathology, The Ohio State University Medical Center, 410 W 10(th) Ave., 401 Doan Hall, Columbus, OH 43210. Electronic address:

Choriocarcinoma can be difficult to differentiate from other subtypes of testicular germ cell tumor and can occur unexpectedly in a distant, late metastasis. The aim of this investigation was to identify a marker superior to β-hCG for choriocarcinoma. 62 primary and metastatic testicular germ cell tumors (27 choriocarcinomas, 19 yolk sac tumors, 29 embryonal carcinomas, 28 seminomas, 22 teratomas, 3 epithelioid trophoblastic tumors (ETT)), were analyzed for immunohistochemical expression of CK7, inhibin, p63, and β-hCG. Read More

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October 2018
7 Reads
2.770 Impact Factor

N-cadherin expression in primary and metastatic testicular germ cell tumors.

J BUON 2018 Jul-Aug;23(4):1125-1129

Department of Surgical Pathology, Uludag University School of Medicine, Bursa, Turkey.

Purpose: Upregulation of N-cadherin in epithelial tumor cells has been reported to enhance the invasive process. Although the distribution of N-cadherin in the normal testis was demonstrated, there is no adequate information regarding its presence in testicular germ cell tumors (GCTs). Our purpose was to examine the expression and localization of N-cadherin in germ cell tumors of the testis and share our experience. Read More

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October 2018
2 Reads

PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines.

J Cancer Res Clin Oncol 2018 Oct 24. Epub 2018 Oct 24.

Department of Paediatrics, "Sapienza" University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Purpose: PARP inhibitors (PARPi) are used in a wide range of human solid tumours but a limited evidence is reported in rhabdomyosarcoma (RMS), the most frequent childhood soft-tissue sarcoma. The cellular and molecular effects of Olaparib, a specific PARP1/2 inhibitor, and AZD2461, a newly synthesized PARP1/2/3 inhibitor, were assessed in alveolar and embryonal RMS cells both as single-agent and in combination with ionizing radiation (IR).

Methods: Cell viability was monitored by trypan blue exclusion dye assays. Read More

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October 2018
8 Reads
3.080 Impact Factor

Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma.

Sci Rep 2018 Oct 23;8(1):15674. Epub 2018 Oct 23.

University of Aberdeen, School of Medicine, Medical Sciences and Nutrition, Foresterhill, Aberdeen, AB25 2ZD, Scotland.

Persistent hyperactivity of the Hippo effector YAP in activated satellite cells is sufficient to cause embryonal rhabdomyosarcoma (ERMS) in mice. In humans, YAP is abundant and nuclear in the majority of ERMS cases, and high YAP expression is associated with poor survival. However, YAP1 is rarely mutated in human ERMS. Read More

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October 2018

Embryonal rhabdomyosarcoma within abdomen and pelvis in an adult.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418806728

Department of Gynecology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.

Rhabdomyosarcoma arising in abdomen and pelvis is an uncommon but important type of soft tissue sarcoma, posing a great challenge for clinicians. Sporadic cases of intra-abdominal rhabdomyosarcoma were reported, but mostly in pediatrics. We demonstrated a rare case of primary abdominopelvic rhabdomyosarcoma in an elderly woman who presented with a notable increase in abdominal circumference and constipation. Read More

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October 2018
5 Reads

Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report.

Onco Targets Ther 2018 12;11:6853-6862. Epub 2018 Oct 12.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,

Malignant mixed ovarian germ cell tumors are very rare, accounting for ~5.3% of all malignant ovarian germ cell tumors (MOGCTs), with a very high degree of malignancy. The treatment of patients with persistent, refractory, or platinum-resistant MOGCT is not well defined. Read More

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October 2018
2 Reads

A nationwide, population-based epidemiologic study of childhood brain tumors in Korea, 2005-2014: A comparison with United States data.

Cancer Epidemiol Biomarkers Prev 2018 Oct 22. Epub 2018 Oct 22.

Center for Pediatric Oncology, National Cancer Center

Background: We investigated the epidemiologic characteristics of childhood brain tumors (CBTs) in Korea, and compared our findings to those from the US.

Methods: We searched the Korea National Cancer Incidence Database of the Korea Central Cancer Registry (KCCR) from 2005 to 2014, which included all Korean patients with CBT aged 0-19 years at diagnosis. The age-standardized incidence rates (ASRs) and the 5-year relative survival rate (RSRs) were determined. Read More

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October 2018
4 Reads

Sperm imprinting integrity in seminoma patients?

Clin Epigenetics 2018 Oct 19;10(1):125. Epub 2018 Oct 19.

Université Bourgogne Franche-Comté-Equipe Génétique des Anomalies du Développement (GAD) INSERM UMR1231, 2 Rue Angélique Ducoudray, F-21000, Dijon, France.

Background: Testicular germ cell tumor such as seminoma is strongly associated with male reproductive problems commonly associated with the alteration of sperm parameters as described in testicular dysgenesis syndrome. Interestingly, numerous studies have reported that the precursor of germ cell cancer, germ cell neoplasia in situ (GCNIS), present similarities to fetal gonocytes, specifically characterized by global DNA hypomethylation particularly on imprinting sequences. These disorders may have a common origin derived from perturbations of embryonal programming during fetal development. Read More

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October 2018
4 Reads

Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children's Oncology Group Randomized ACNS0332 Trial.

J Clin Oncol 2018 Oct 17:JCO2017764720. Epub 2018 Oct 17.

Eugene I. Hwang and Roger J. Packer, Children's National Medical Center, Washington, DC; Marcel Kool, Lukas Chavez, Sebastian Brabetz, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; David Capper, Andreas von Deimling, and Stefan M. Pfister, University Hospital Heidelberg; Stefan M. Pfister, National Center for Tumor Diseases, Heidelberg; David Capper, Charité Medical University, Berlin, Germany; Peter C. Burger, Johns Hopkins University, Baltimore, MD; Chris Williams-Hughes, Children's Oncology Group, Littleton, CO; Catherine Billups, Yimei Li, and Amar Gajjar, St Jude Children's Research Hospital, Memphis, TN; Linda Heier, Weill Cornell Medical College, New York, NY; Alok Jaju, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Jeff Michalski, Washington University School of Medicine, St. Louis, MO; Sarah Leary and James M. Olson, Seattle Children's Hospital and Research Institute; Sarah Leary and James M. Olson, Fred Hutchinson Cancer Research Center, Seattle, WA; Tianni Zhou, California State University, Long Beach, Long Beach, CA; Maryam Fouladi, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and Ian F. Pollack, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA.

Purpose: Children with histologically diagnosed high-risk medulloblastoma, supratentorial primitive neuroectodermal tumor of the CNS (CNS-PNET), and pineoblastoma (PBL) have had poor survival despite intensive treatment. We included these patients in this Children's Oncology Group trial. Molecular profiling later revealed tumor heterogeneity that was not detectable at protocol inception. Read More

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October 2018
9 Reads

Identification of therapeutic targets in chordoma through comprehensive genomic and transcriptomic analyses.

Cold Spring Harb Mol Case Stud 2018 Oct 15. Epub 2018 Oct 15.

St. Joseph's Hospital and Medical Center.

Chordoma is a rare, orphan cancer arising from embryonal precursors of bone. Surgery and radiotherapy (RT) provide excellent local control, often at the price of significant morbidity due to the structures involved and the need for relatively high doses of RTare not typically curative; however, recurrence remains high. Although our understanding of the genetic changes that occur in chordoma is evolving rapidly, this knowledge has yet to translate into treatments. Read More

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October 2018
1 Read

Myxoid Lipoblastoma and Mimickers on Fine-Needle Biopsy in a Child.

Pediatr Dev Pathol 2018 Oct 15:1093526618805894. Epub 2018 Oct 15.

1 Service d'Anatomie et de Cytologie Pathologiques, Hôpital d'Enfants Armand Trousseau, Université Pierre et Marie Curie, Paris, France.

Image-guided percutaneous core needle biopsy is a standard and safe procedure for the diagnosis of both solid and hematological malignancies in children. Despite recent improvements, nondiagnosis biopsies persist. Lipoblastoma is a benign adipocytic tumor composed of embryonal fat admixed with mature adipocytes and occurring before the age of 1 year in one-third of cases. Read More

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October 2018
6 Reads

Different Response of Mutant and Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors.

Front Oncol 2018 25;8:396. Epub 2018 Sep 25.

Institute for Human Genetics, University Medical Center Goettingen, Goettingen, Germany.

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS frequently show Hedgehog (HH) pathway activity, which is predominantly seen in the embryonal subtype (ERMS). They also show activation of Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) signaling. Read More

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September 2018

Treatment of Hepatic Embryonal Undifferentiated Sarcoma With Cardiothoracic Involvement.

World J Pediatr Congenit Heart Surg 2018 Oct 14:2150135118775411. Epub 2018 Oct 14.

1 Department of Cardiovascular Surgery, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Thorough study is required to decide the appropriate management of hepatic tumors in children. We present a case report of a hepatic embryonal undifferentiated sarcoma with unfavorable prognosis in a nine-year-old girl. After undergoing a detailed cancer characteristics and extension study, a two-stage surgery approach was decided. Read More

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October 2018
1 Read

Boron inhibits apoptosis in hyperapoptosis condition: Acts by stabilizing the mitochondrial membrane and inhibiting matrix remodeling.

Biochim Biophys Acta Gen Subj 2019 Jan 10;1863(1):144-152. Epub 2018 Oct 10.

Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard (Deemed University), Hamdard Nagar, New Delhi 110062, India. Electronic address:

An abnormally high apoptosis has been associated with a number of clinical conditions including embryonal malformations and various pathologies such as neuronal degeneration and diabetes. In this study, boron is reported to inhibit apoptosis in hyperapoptosis conditions as demonstrated in a model of hyperapoptosis. Boron is a metalloid which is present in food in small amounts and is suggested here to inhibit apoptosis by stabilizing the mitochondrial membrane structure, thus preventing matrix remodeling and the release of cytochrome c, an apoptosis-inducer protein from the mitochondrion. Read More

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January 2019
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The histone deacetylase inhibitor Suberoylanilide Hydroxamic Acid (SAHA) as a therapeutic agent in rhabdomyosarcoma.

Cancer Biol Ther 2018 Oct 11:1-12. Epub 2018 Oct 11.

b Department of Pediatrics and Adolescent Medicine , American University of Beirut , Beirut , Lebanon.

Rhabdomyosarcoma (RMS) is an aggressive childhood sarcoma with two distinct subtypes, embryonal (ERMS) and alveolar (ARMS) histologies. More effective treatment is needed to improve outcomes, beyond conventional cytotoxic chemotherapy. The pan-histone deacetylase inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), has shown promising efficacy in limited preclinical studies. Read More

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October 2018
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Metabolic profile and differentiation potential of extraembryonic endoderm-like cells.

Cell Death Discov 2018 26;4:42. Epub 2018 Sep 26.

1Department of Biology, Collaborative Graduate Specialization in Developmental Biology, The University of Western Ontario, London, ON Canada.

Glucose metabolism has a crucial role for providing substrates required to generate ATP and regulate the epigenetic landscape. We reported that F9 embryonal carcinoma stem-like cells require cytosolic reactive oxygen species to differentiate into extraembryonic endoderm; however, mitochondrial sources were not examined. To extend these studies, we examined the metabolic profile of early and late-passage F9 cells, and show that their ability to differentiate is similar, even though each population has dramatically different metabolic profiles. Read More

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September 2018
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