6,670 results match your criteria Embryonal Carcinoma


Meta-Analysis of Gene Expressions in Testicular Germ Cell Tumor Histologies.

Int J Mol Sci 2020 Jun 24;21(12). Epub 2020 Jun 24.

Facultad de Ciencias Informaticas, Universidad Tecnica de Manabi, Portoviejo 130105, Ecuador.

There is no consensus as to how a precursor lesion, germ cell neoplasia in situ (GCNIS), develops into the histologic types of testicular germ cell tumor type II (TGCT). The present meta-analysis examined RNA expressions of 24 candidate genes in three datasets. They included 203 samples of normal testis (NT) and histologic types of TGCT. Read More

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http://dx.doi.org/10.3390/ijms21124487DOI Listing

HNF1β is a sensitive and specific novel marker for yolk sac tumor: a tissue microarray analysis of 601 testicular germ cell tumors.

Mod Pathol 2020 Jun 19. Epub 2020 Jun 19.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Hepatocyte Nuclear Factor 1 beta (HNF1β) is a transcription factor which plays an important role during early organogenesis, especially of the pancreato-biliary and urogenital tract. Furthermore, HNF1β is an established marker in the differential diagnosis of ovarian cancer and shows a distinct nuclear expression in the clear cell carcinoma subtype. Recently, it has been described in yolk sac tumor, which represents a common component in many non-seminomatous germ cell tumors. Read More

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http://dx.doi.org/10.1038/s41379-020-0597-xDOI Listing

Two subsequent metachroneus solid tumors: Oncocytic variant adrenocortical carcinoma and rhabdomyosarcoma of childhood: Case report and Literature Review.

J Clin Res Pediatr Endocrinol 2020 Jun 16. Epub 2020 Jun 16.

Pediatrics, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.

Most cases of malignancies appear to be sporadic, but some syndromes are associated with malignancies with germline variants. Herein, a child with an unusual association of oncocytic variant adrenocortical carcinoma (ACC) and rhabdomyosarcoma was presented. An 18-month-old-boy was admitted with virilization of the genital area, penis enlargement, and erection which had begun six months ago. Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2020.2020.0060DOI Listing

Diagnosis of intracranial embryonal carcinoma by cerebrospinal fluid cytology: a case report.

Int J Clin Exp Pathol 2020 1;13(5):1216-1219. Epub 2020 May 1.

Department of Geriatric Medicine, Qingdao University Affiliated Yantai Yuhuangding Hospital Qingdao, China.

Background: The incidence of primary intracranial germ cell tumors (GCTs) is relatively low comparing to other ones. Embryonal carcinoma (EC) is an especially rare subtype and the diagnosis presents to be a challenge. Few cases have been reported. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270687PMC

Embryonal carcinoma of an intraabdominal testicular tumor on an undescended testicle: a case report.

Med Pharm Rep 2020 Apr 22;93(2):213-218. Epub 2020 Apr 22.

Department of Medical Imaging, Iuliu Hatieganu University of Medicine and Pharmacy, "Prof. Dr. Octavian Fodor", Regional Institute of Gastroenterology and Hepatology Cluj-Napoca, Romania.

Cryptorchidism, as a singular pathology or associated with other dysgenesis syndromes, is one of the main factors of risk for the development of the testicular tumors. Although there are a great number of cases of undescended testicles that are diagnosed and treated during the first 6-12 months of life, there are rare cases of adults who are undiagnosed and untreated from this anomaly, which can present a high risk of malignancy. In this study we present the case of a 36-year-old patient, diagnosed at puberty with left cryptorchidism, untreated, who also hadevidenced a large intraabdominal tumoral mass associated with it. Read More

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http://dx.doi.org/10.15386/mpr-1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243893PMC

In situ hybridisation for albumin RNA in paediatric liver cancers compared with common immunohistochemical markers.

J Clin Pathol 2020 May 29. Epub 2020 May 29.

Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA

Aims: In situ hybridisation (ISH) for albumin mRNA is a sensitive marker of primary liver tumours in adults. However, paediatric tumours, such as hepatoblastoma (HB) and fibrolamellar hepatocellular carcinoma (FLC), have not been tested thoroughly and may require ancillary tests to diagnose with confidence. We aim to determine if albumin ISH is useful in the pathological evaluation of these malignancies and to compare it to commonly used immunohistochemical markers HepPar 1 (HEPA) and arginase-1 (ARG). Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206663DOI Listing

Fine needle aspiration of mediastinal germ cell tumors.

Semin Diagn Pathol 2020 May 13. Epub 2020 May 13.

Department of Pathology and Laboratory Medicine University of Florida-Jacksonville, Jacksonville, FL.

Germ cell tumors in the mediastinum are rare and often occur in young patients but may occur in older patients. Seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma and teratoma have distinct morphologic features with high grade nuclei. They are the primary diagnostic consideration in young males but may be lower on the list in older patients, where they may be misdiagnosed as carcinomas. Read More

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http://dx.doi.org/10.1053/j.semdp.2020.04.008DOI Listing

Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines.

Cancers (Basel) 2020 May 19;12(5). Epub 2020 May 19.

Department of Pediatric Hematology and Oncology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.

Outcome in high-risk patients with refractory or relapsed germ cell tumours (GCT) remains poor. Novel strategies enhancing therapeutic efficacy whilst limiting therapeutic burden are warranted, yet immunotherapy approaches geared towards activating endogenous antitumor responses have not been successful thus far. Redirection of cytotoxic effector cells by bispecific antibodies represents a promising approach in this setting. Read More

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http://dx.doi.org/10.3390/cancers12051279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281168PMC

CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms.

Br J Cancer 2020 May 18. Epub 2020 May 18.

Department of Urology, Urological Research Lab, Translational UroOncology, University Hospital Düsseldorf, Düsseldorf, Germany.

Background: Germ cell tumours (GCTs) are the most common solid malignancies in young men. Although high cure rates can be achieved, metastases, resistance to cisplatin-based therapy and late toxicities still represent a lethal threat, arguing for the need of new therapeutic options. In this study, we analysed the potential of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors palbociclib and ribociclib (PaRi) as molecular drugs to treat cisplatin-resistant and -sensitive paediatric and adult GCTs. Read More

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http://dx.doi.org/10.1038/s41416-020-0891-xDOI Listing
May 2020
4.836 Impact Factor

Unusual Chemotherapeutic Resistant Testicular Embryonal Germ Cell Tumor with Widespread Metastasis in a Case of Klinefelter Syndrome: A Case Report.

Cureus 2020 Apr 11;12(4):e7637. Epub 2020 Apr 11.

Medical Oncology, Larkin Community Hospital, Miami, USA.

Cryptorchidism is an undeniable risk factor for testicular germ cell tumors (TGCTs) and is also commonly associated with Klinefelter syndrome (KS) patients. Embryonal cell carcinoma usually shows strong expression of CD30 and OCT3/4, with patchy staining of PLAP1. Most patients with nonseminomatous GCTs (NSGCTs) can achieve total remission with proactive chemotherapy, and most can be cured. Read More

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http://dx.doi.org/10.7759/cureus.7637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213769PMC

Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells.

RNA Biol 2020 May 6:1-12. Epub 2020 May 6.

Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore , Singapore.

PIWI homologs constitute a subclass of the Argonaute family. Traditionally, they have been shown to associate with a specific class of small RNAs, piRNAs, to suppress transposable elements and protect genomic integrity in germ cells. Recent studies imply that PIWI proteins may also exert important biological functions in somatic contexts, including the brain. Read More

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http://dx.doi.org/10.1080/15476286.2020.1757896DOI Listing

Retinoic Acid-Regulated Target Genes During Development: Integrative Genomics Analysis.

Subcell Biochem 2020 ;95:57-85

Université de Strasbourg, IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), INSERM, U964, CNRS, UMR7104, 1 rue Laurent Fries, BP 10142, 67404, Illkirch Cedex, France.

Retinoic acid (RA), a major natural active metabolite of vitamin A (VA) is well known to play critical roles in embryonic development. The effects of RA are mediated by nuclear receptors (RARs), which regulate the expression of gene batteries involved in cell growth and differentiation. Since the early 1990s several laboratories have focused on understanding how RA-regulated genes and RAR binding sites operate by studying the differentiation of embryonal carcinoma cells and embryonic stem cells. Read More

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http://dx.doi.org/10.1007/978-3-030-42282-0_3DOI Listing

Pulmonary metastasis: very late relapse of testicular embryonal carcinoma.

Monaldi Arch Chest Dis 2020 Apr 8;90(1). Epub 2020 Apr 8.

Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples.

Testicular carcinoma recurrences represent a rare finding (1-6% in non-seminomatous germ cell tumours). However, cases of recurrence have been described many years later. We report a case of late recurrence of embryonic testicular carcinoma, after 26 years, with pulmonary metastases. Read More

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http://dx.doi.org/10.4081/monaldi.2020.1206DOI Listing

Rhabdomyosarcoma: Nose Presenting As Second Primary with Carcinoma Tongue.

Iran J Otorhinolaryngol 2020 Mar;32(109):121-125

Department of Pathology, Lady Hardinge Medical College, New Delhi (India)-110001.

Introduction: Presence of two primary malignancies is rare and occurs in 3-5% of the cancer patients. As per our extensive internet research, this is the only reported case of a synchronous sino-nasal embryonal rhabdomyosarcoma with squamous cell carcinoma-tongue. The case report is important because of the rare diagnosis and the challenge we faced in the diagnosis and treatment of the patient because of the paucity of literature available on management adult rhabdomyosarcoma. Read More

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http://dx.doi.org/10.22038/ijorl.2019.41435.2351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085931PMC

Usefulness of plasma full-length glypican-3 as a predictive marker of hepatocellular carcinoma recurrence after radial surgery.

Oncol Lett 2020 Apr 5;19(4):2657-2666. Epub 2020 Feb 5.

Division of Cancer Immunotherapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan.

Predicting the risk of hepatocellular carcinoma (HCC) recurrence before treatment is necessary for developing subsequent treatment policies. Several tumor markers found in blood, such as alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II), are presently used to determine the occurrence and recurrence of HCC and to predict patient prognosis. However, these markers are insufficient for these purposes as certain patients have HCC recurrence despite exhibiting negative AFP and PIVKA-II. Read More

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http://dx.doi.org/10.3892/ol.2020.11371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068289PMC

Neuroprotective effects of boron nitride nanoparticles in the experimental Parkinson's disease model against MPP+ induced apoptosis.

Metab Brain Dis 2020 Mar 25. Epub 2020 Mar 25.

Department of Pharmacology, G. D'Annunzio University, Chieti, Italy.

Parkinson's disease (PD) is one of the most aggressive neurodegenerative diseases and characterized by the loss of dopamine-sensitive neurons in the substantia nigra region of the brain. There is no any definitive treatment to completely cure PD and existing treatments can only ease the symptoms of the disease. Boron nitride nanoparticles have been extensively studied in nano-biological studies and researches showed that it can be a promising candidate for PD treatment with its biologically active unique properties. Read More

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http://dx.doi.org/10.1007/s11011-020-00559-6DOI Listing

Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers: IV: Current and Future Utilization of Molecular-Genetic Tests for Testicular Germ Cell Tumors.

Am J Surg Pathol 2020 Jul;44(7):e66-e79

Pathology, Indiana University School of Medicine, Indianapolis, IN.

The International Society of Urological Pathology (ISUP) organized a Consultation Conference in March 2019 dealing with applications of molecular pathology in Urogenital Pathology, including testicular tumors (with a focus on germ cell tumors [GCTs]), preceded by a survey among its members to get insight into current practices in testicular germ cell tumor (TGCT) diagnostics and adoption of the ISUP immunohistochemical guidelines published in 2014. On the basis of the premeeting survey, the most commonly used immunomarker panel includes OCT3/4, placental alkaline phosphate, D2-40, SALL4, CD117, and CD30 for GCTs and the documentation of germ cell neoplasia in situ (GCNIS). Molecular testing, specifically 12p copy gain, is informative to distinguish non-GCNIS versus GCNIS related GCTs, and establishing germ cell origin of tumors both in the context of primary and metastatic lesions. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289140PMC
July 2020
5.145 Impact Factor

Liver Transplantation for Pediatric Liver Cancer.

Cancers (Basel) 2020 Mar 19;12(3). Epub 2020 Mar 19.

Department of Pathology, Children's Hospital Medical Center of Cincinnati, Cincinnati, OH 45229, USA.

Unresectable hepatocellular carcinoma (HCC) was first removed successfully with total hepatectomy and liver transplantation (LT) in a child over five decades ago. Since then, children with unresectable liver cancer have benefitted greatly from LT and a confluence of several equally important endeavors. Regional and trans-continental collaborations have accelerated the development and standardization of chemotherapy regimens, which provide disease control to enable LT, and also serve as a test of unresectability. Read More

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http://dx.doi.org/10.3390/cancers12030720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140094PMC

Prevalence of CD8 cytotoxic lymphocytes in human neoplasms.

Cell Oncol (Dordr) 2020 Jun 5;43(3):421-430. Epub 2020 Mar 5.

Institute of Pathology, Martinistraße 52, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.

Purpose: Immune checkpoint inhibitors have recently been approved by the US FDA as first and/or second line therapy in a subset of cancer types. Recent evidence suggests that the quantity of tumor infiltrating lymphocytes (TILs) influences the likelihood of response to immune checkpoint inhibitors. Here, we set out to assess the density of CD8 lymphocytes in a wide range of different cancer types and subtypes. Read More

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http://dx.doi.org/10.1007/s13402-020-00496-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214387PMC

Detailed overview on rare malignant ovarian tumors.

Bull Cancer 2020 Mar 27;107(3):385-390. Epub 2020 Feb 27.

Department of Medical Oncology, centre Léon-Bérard, University Claude Bernard (UCBL Lyon1), Lyon, France. Electronic address:

The group of rare malignant ovarian tumors includes the group of germ cell tumors, sex cords stromal ovarian tumors, small cell carcinoma, malignant Brenner tumors, rare epithelial tumors such as mucinous carcinoma, clear cell carcinoma, or low-grade serous carcinoma, as well as ovarian carcinosarcoma. Together they comprise about 10% of all ovarian tumors. Due to their low prevalence and their heterogeneity, data and treatment recommendations are limited. Read More

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http://dx.doi.org/10.1016/j.bulcan.2020.01.011DOI Listing

Adjuvant Chemotherapy With Etoposide Plus Cisplatin for Patients With Pathologic Stage II Nonseminomatous Germ Cell Tumors.

J Clin Oncol 2020 Apr 28;38(12):1332-1337. Epub 2020 Feb 28.

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: The relapse rate after primary retroperitoneal lymph node dissection (RPLND) for patients with pathologic stage (PS) IIA nonseminomatous germ cell tumors (NSGCTs) is 10%-20% but increases to ≥ 50% for PS IIB disease. We report our experience with 2 cycles of adjuvant etoposide plus cisplatin (EP×2) after therapeutic primary RPLND.

Patients And Methods: All patients with PS II NSGCT seen at Memorial Sloan Kettering Cancer Center from March 1989 to April 2016 and who were planned to receive EP×2 were included. Read More

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http://dx.doi.org/10.1200/JCO.19.02712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164484PMC

Mixed Germ Cell Tumor of the Endometrium: A Case Report and Literature Review.

Open Med (Wars) 2020 4;15:65-70. Epub 2020 Feb 4.

Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014, People's Republic of China.

Germ cell tumors (GCTs) localized extragonadally are rare, with only 14 reported cases of a yolk sac tumor in the endometrium. Here we report a case of mixed endometrium GCTs in a 65-year-old postmenopausal woman with abnormal vaginal bleeding. An ultrasound examination showed an oval-shaped mass in the patient's uterine cavity. Read More

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http://dx.doi.org/10.1515/med-2020-0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005913PMC
February 2020

Cancer Stem Cell Niche and Immune-Active Tumor Microenvironment in Testicular Germ Cell Tumors.

Adv Exp Med Biol 2020 ;1226:111-121

Translational Research Unit, Faculty of Medicine, Comenius University and National Cancer Institute, Bratislava, Slovakia.

Testicular germ cell tumors (TGCTs) represent the most common neoplasia among young men. Management of TGCTs is an excellent example of curative outcomes in clinical oncology. The unique sensitivity to cisplatin-based chemotherapy regimens has led to establishing TGCTs as a "model of cancer cure. Read More

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http://dx.doi.org/10.1007/978-3-030-36214-0_9DOI Listing
February 2020

Oct4-Mediated Inhibition of Lsd1 Activity Promotes the Active and Primed State of Pluripotency Enhancers.

Cell Rep 2020 Feb;30(5):1478-1490.e6

Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA; Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address:

An aberrant increase in pluripotency gene (PpG) expression due to enhancer reactivation could induce stemness and enhance the tumorigenicity of cancer stem cells. Silencing of PpG enhancers (PpGe) during embryonic stem cell differentiation involves Lsd1-mediated H3K4me1 demethylation and DNA methylation. Here, we observed retention of H3K4me1 and DNA hypomethylation at PpGe associated with a partial repression of PpGs in F9 embryonal carcinoma cells (ECCs) post-differentiation. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316367PMC
February 2020

Distributed automated manufacturing of pluripotent stem cell products.

Int J Adv Manuf Technol 2020 4;106(3):1085-1103. Epub 2019 Dec 4.

1Centre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, Leicestershire LE11 3TU UK.

Establishing how to effectively manufacture cell therapies is an industry-level problem. Decentralised manufacturing is of increasing importance, and its challenges are recognised by healthcare regulators with deviations and comparability issues receiving specific attention from them. This paper is the first to report the deviations and other risks encountered when implementing the expansion of human pluripotent stem cells (hPSCs) in an automated three international site-decentralised manufacturing setting. Read More

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http://dx.doi.org/10.1007/s00170-019-04516-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954896PMC
December 2019

Diagnosis and Management of Intratubular Germ Cell Neoplasia In Situ: A Systematic Review.

J Urol 2020 07 22;204(1):33-41. Epub 2020 Jan 22.

Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Purpose: We performed a systematic review of studies assessing the diagnosis and effectiveness of management strategies for germ cell neoplasia in situ.

Materials And Methods: Paired investigators independently searched for studies on the diagnosis and management of testicular germ cell neoplasia in situ using PubMed®, Embase® and the Cochrane Central Register of Controlled Trials from January 1, 1980 through August 2018. The reviewers then extracted data and assessed quality. Read More

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http://dx.doi.org/10.1097/JU.0000000000000758DOI Listing

All-trans-retinoid acid induces the differentiation of P19 cells into neurons involved in the PI3K/Akt/GSK3β signaling pathway.

J Cell Biochem 2020 Jan 21. Epub 2020 Jan 21.

Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

The pluripotent mouse embryonal carcinoma cell line P19 is widely used as a model for research on all-trans-retinoid acid (RA)-induced neuronal differentiation; however, the signaling pathways involved in this process remain unclear. This study aimed to reveal the molecular mechanism underlying the RA-induced neuronal differentiation of P19 cells. Real-time quantitative polymerase chain reaction and Western blot analysis were used to determine the expression of neuronal-specific markers, whereas flow cytometry was used to analyze cell cycle and cell apoptosis. Read More

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http://dx.doi.org/10.1002/jcb.29659DOI Listing
January 2020

Vernolactone Promotes Apoptosis and Autophagy in Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells.

Stem Cells Int 2019 19;2019:6907893. Epub 2019 Dec 19.

Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, No. 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.

, is a shrub endemic to Sri Lanka. has been used in Sri Lankan traditional medicine for the treatment of various diseases and conditions. The present study was designed to determine antiproliferative, apoptotic, autophagic, and antioxidant effects of vernolactone, isolated from , in human embryonal carcinoma cells (NTERA-2, a cancer stem cell model). Read More

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http://dx.doi.org/10.1155/2019/6907893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942914PMC
December 2019

Malignant Mixed Germ Cell Tumors of the Ovary: A Series of Rare Cases.

J Reprod Infertil 2019 Oct-Dec;20(4):231-236

Department of Pathology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

Background: Malignant mixed germ cell tumors of ovary are rare aggressive cancers affecting young adolescent girls. The commonest combination reported in literature is dysgerminoma and endodermal sinus tumors but in our study the most common combination was immature teratoma and endodermal sinus tumor which is exteremely rare. Preservation of future fertility is a concern. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928409PMC
January 2020

[Progression of diagnosis and treatment in pediatric colorectal carcinoma].

Authors:
J Y Yan Y J Chen

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Dec;22(12):1216-1220

National Center of Children's Health, Department of General Surgery, Beijing Children Hospital, Capital Medical University, Beijing 100045, China.

Colorectal carcinoma (CRC) is the third most common malignancy in adults. Pediatric colorectal carcinoma (PCRC) is a rare non-embryonal tumor with a significantly lower incidence compared to adults. The clinical manifestations of PCRC are not typical, and pediatricians usually have no enough experience in diagnosis and treatment. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1671-0274.2019.12.021DOI Listing
December 2019

Cannabinoid Receptors Signaling in the Development, Epigenetics, and Tumours of Male Germ Cells.

Int J Mol Sci 2019 Dec 18;21(1). Epub 2019 Dec 18.

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.

Endocannabinoids are natural lipid molecules whose levels are regulated by specific biosynthetic and degradative enzymes. They bind to and activate two main cannabinoid receptors type 1 (CB) and type 2 (CB), and together with their metabolizing enzymes form the "endocannabinoid system" (ECS). In the last years, the relevance of endocannabinoids (eCBs) as critical modulators in various aspects of male reproduction has been pointed out. Read More

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http://dx.doi.org/10.3390/ijms21010025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981618PMC
December 2019

Pre-sternal thyroid swellings: a case of rare aberrant site recurrence and review of literature.

Thyroid Res 2019 21;12:12. Epub 2019 Nov 21.

3Department of Transfusion Medicine, All India Institute of Medical Sciences, Rishikesh, India.

Background: Thyroid swellings enlarge caudally into the mediastinum behind the sternum. Pre-sternal swelling of thyroid origin is very rare. We present our case of pre-sternal thyroid swelling which was albeit a surprisingly rare site of papillary thyroid carcinoma recurrence and review of pre-sternal thyroid swellings reported till date. Read More

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http://dx.doi.org/10.1186/s13044-019-0073-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868756PMC
November 2019

Maintenance of active chromatin states by HMGN2 is required for stem cell identity in a pluripotent stem cell model.

Epigenetics Chromatin 2019 12 12;12(1):73. Epub 2019 Dec 12.

Institute of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.

Background: Members of the HMGN protein family modulate chromatin structure and influence epigenetic modifications. HMGN1 and HMGN2 are highly expressed during early development and in the neural stem/progenitor cells of the developing and adult brain. Here, we investigate whether HMGN proteins contribute to the chromatin plasticity and epigenetic regulation that is essential for maintaining pluripotency in stem cells. Read More

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http://dx.doi.org/10.1186/s13072-019-0320-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907237PMC
December 2019

Primary Sarcomas of the Larynx: A Single Institutional Experience with Ten Cases.

Head Neck Pathol 2019 Dec 7. Epub 2019 Dec 7.

Department of Pathology, University of Washington, 1959 NE Pacific Street, Box 356100, Seattle, WA, 98195, USA.

Sarcomas infrequently arise in the larynx where the vast majority of tumors are of epithelial origin. Given their rarity, studies of these lesions are limited in number. In this series, we describe our institutional experience with ten primary sarcomas of the larynx encountered over an 18 year period, comprising 1. Read More

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http://dx.doi.org/10.1007/s12105-019-01106-1DOI Listing
December 2019

Lymphovascular invasion and presence of embryonal carcinoma as risk factors for occult metastatic disease in clinical stage I nonseminomatous germ cell tumour: a systematic review and meta-analysis.

BJU Int 2020 Mar 8;125(3):355-368. Epub 2020 Jan 8.

Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Objective: To systematically review the literature on the prognostic value of lymphovascular invasion (LVI) and embryonal carcinoma (EC) for occult metastatic disease in clinical stage I nonseminomatous germ cell tumour (CS I NSGCT).

Materials And Methods: The PubMed, Embase (OVID) and SCOPUS databases were searched up to March 2019. Studies reporting on the association between LVI and/or EC and occult metastatic disease were considered for inclusion. Read More

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http://dx.doi.org/10.1111/bju.14967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065076PMC

Rapidly enlarging abdominal mass in a patient with recurrent germ cell tumor.

Clin Case Rep 2019 Nov 7;7(11):2285-2286. Epub 2019 Oct 7.

Department of Genitourinary Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA.

This clinical image illustrates the alarming growth rate for an embryonal carcinoma, as well as its highly curable nature. For similar cases, early diagnosis and treatment are key. Read More

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http://dx.doi.org/10.1002/ccr3.2476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878095PMC
November 2019

The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells.

BMC Cancer 2019 Nov 19;19(1):1124. Epub 2019 Nov 19.

MRC Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, EH16 4TJ, UK.

Background: Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. GCNIS originates from fetal gonocytes (POU5F1/MAGE-A4), which fail to differentiate to pre-spermatogonia (POU5F1/MAGE-A4) and undergo malignant transformation. Gankyrin is an oncogene which has been shown to prevent POU5F1 degradation and specifically interact with MAGE-A4 in hepatocellular carcinoma (HCC) cells. Read More

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http://dx.doi.org/10.1186/s12885-019-6340-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862764PMC
November 2019

Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers.

Sci Rep 2019 11 14;9(1):16830. Epub 2019 Nov 14.

Department of Pathology, NYU Langone Health and School of Medicine, New York, NY, USA.

IDH1/2 mutations are early drivers present in diverse human cancer types arising in various tissue sites. IDH1/2 mutation is known to induce a global hypermethylator phenotype. However, the effects on DNA methylation across IDH mutant cancers and functionally different genome regions, remain unknown. Read More

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http://dx.doi.org/10.1038/s41598-019-53262-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856069PMC
November 2019
4 Reads

Commentary: Rare Primary Embryonal Carcinoma in the Brachial Plexus: A Case Report and Literature Review.

Authors:
Ian E McCutcheon

Neurosurgery 2019 Nov 6. Epub 2019 Nov 6.

Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1093/neuros/nyz469DOI Listing
November 2019
1 Read

The multidisciplinary approach to ovarian tumours in children and adolescents.

Eur J Obstet Gynecol Reprod Biol 2019 Dec 21;243:103-110. Epub 2019 Oct 21.

Multidisciplinary Breast Clinic, Unit of Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Belgium; Department of Obstetrics and Gynaecology, Antwerp University Hospital, University of Antwerp, Belgium.

Ovarian tumours in children and adolescents are rare diseases. Although the majority of tumours are benign, the diagnosis and management present various challenges that require a wide range of expertise. The multidisciplinary team ensures not only accurate diagnosis and correct and minimally invasive management, but also minimal psychological impact and the preservation of fertility. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.10.032DOI Listing
December 2019

A case of contralateral superficial inguinal recurrence of testicular embryonal carcinoma.

Urol Case Rep 2019 Nov 7;27:101012. Epub 2019 Sep 7.

Section of Urology, Department of Surgery, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, 03756, USA.

Metastatic embyronal carcinoma to the subcutaneous tissues is rare. Prior cases have occurred in the setting of undiagnosed widely metastatic disease. Here we present the first case of metastatic embyronal cancer to the contralateral subcutaneous inguinal region in the absence of any other sites of metastatic disease. Read More

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http://dx.doi.org/10.1016/j.eucr.2019.101012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796596PMC
November 2019

Rare malignant liver tumors in children.

Pediatr Radiol 2019 10 16;49(11):1404-1421. Epub 2019 Oct 16.

Department of Pediatrics, University of Toronto, Toronto, ON, Canada.

Malignant hepatic tumors in children are rare, comprising 1.3% of all pediatric malignancies. Following hepatoblastoma, hepatocellular carcinoma is the second most common. Read More

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http://link.springer.com/10.1007/s00247-019-04402-8
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http://dx.doi.org/10.1007/s00247-019-04402-8DOI Listing
October 2019
5 Reads
1.651 Impact Factor

Diseases Predisposing to Adrenocortical Malignancy (Li-Fraumeni Syndrome, Beckwith-Wiedemann Syndrome, and Carney Complex).

Exp Suppl 2019 ;111:149-169

Endocrinology Department, Cochin Hospital, APHP, Paris, France.

Adrenocortical malignancies can occur in the context of several tumor predisposition syndromes.The Carney complex (CNC) is responsible for the majority of primary pigmented nodular adrenal diseases and is more rarely associated with adrenocortical carcinoma (ACC). Other core manifestations of CNC include cardiac and cutaneous myxomas, lentiginosis, somatotroph pituitary adenomas, Sertoli tumors, melanocytic schwannoma, and thyroid, breast, and bone tumors. Read More

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http://dx.doi.org/10.1007/978-3-030-25905-1_9DOI Listing
October 2019
4 Reads

Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate.

Int J Cancer 2020 03 1;146(6):1592-1605. Epub 2019 Nov 1.

Department of Developmental Pathology, Institute of Pathology, University of Bonn Medical School, Bonn, Germany.

Embryonal carcinomas (ECs) and seminomas are testicular germ cell tumors. ECs display expression of SOX2, while seminomas display expression of SOX17. In somatic differentiation, SOX17 drives endodermal cell fate. Read More

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http://dx.doi.org/10.1002/ijc.32714DOI Listing
March 2020
2 Reads
5.085 Impact Factor

Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features.

Cancer Med 2019 11 30;8(16):6832-6840. Epub 2019 Sep 30.

Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "L. Vanvitelli", Naples, Italy.

Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis from occult gonadal neoplasms. The actual observations suggest that EGGCTs represent a unique entity, so their biology and behavior are substantially different from gonadal counterparts. Read More

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http://dx.doi.org/10.1002/cam4.2195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853824PMC
November 2019
3 Reads

Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines.

Dis Markers 2019 3;2019:8298524. Epub 2019 Sep 3.

Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.

Malignant germ cell tumors (GCT) are the most common malignant tumors in young men between 18 and 40 years. The correct identification of histological subtypes, in difficult cases supported by immunohistochemistry, is essential for therapeutic management. Furthermore, biomarkers may help to understand pathophysiological processes in these tumor types. Read More

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http://dx.doi.org/10.1155/2019/8298524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745167PMC
February 2020
4 Reads

Technique and outcome of domino liver transplantation from patients with maple syrup urine disease: Expanding the donor pool for live donor liver transplantation.

Clin Transplant 2019 11 6;33(11):e13721. Epub 2019 Oct 6.

Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Thomas E. Starzl Transplant Institute, Pittsburgh, PA, USA.

Aim/background: Domino liver transplantation (DLT) using liver allografts from patients with metabolic disorders enhances organ utilization. Short- and long-term course and outcome of these patients can impact the decision to offer this procedure to patients, especially those with diseases that can potentially be cured with liver transplant. We reviewed the outcomes of DLT from maple syrup urine disease (MSUD) patients in our large academic pediatric and adult transplant program. Read More

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http://dx.doi.org/10.1111/ctr.13721DOI Listing
November 2019
3 Reads