6,569 results match your criteria Embryonal Carcinoma


Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression.

Epigenetics Chromatin 2019 Apr 16;12(1):22. Epub 2019 Apr 16.

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, 100020, China.

Background: Neural tube defects (NTDs) are common birth defects involving the central nervous system. Recent studies on the etiology of human NTDs have raised the possibility that epigenetic regulation could be involved in determining susceptibility to them.

Results: Here, we show that the H2AK119ub1 E3 ligase CUL4B is required for the activation of retinoic acid (RA)-inducible developmentally critical homeobox (HOX) genes in NT2/D1 embryonal carcinoma cells. Read More

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http://dx.doi.org/10.1186/s13072-019-0268-7DOI Listing
April 2019
2 Reads

Increased Expression of Cell Surface SSEA-1 is Closely Associated with Naïve-Like Conversion from Human Deciduous Teeth Dental Pulp Cells-Derived iPS Cells.

Int J Mol Sci 2019 Apr 3;20(7). Epub 2019 Apr 3.

Section of Gene Expression Regulation, Frontier Science Research Center, Kagoshima University, Kagoshima 890-8544, Japan.

Stage-specific embryonic antigen 1 (SSEA-1) is an antigenic epitope (also called CD15 antigen) defined as a Lewis X carbohydrate structure and known to be expressed in murine embryonal carcinoma cells, mouse embryonic stem cells (ESCs), and murine and human germ cells, but not human ESCs/induced pluripotent stem cells (iPSCs). It is produced by α1,3-fucosyltransferase IX gene (), and F9 ECCs having a disrupted locus by gene targeting are reported to exhibit loss of SSEA-1 expression on their cell surface. Mouse ESCs are pluripotent cells and therefore known as "naïve stem cells (NSCs). Read More

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http://dx.doi.org/10.3390/ijms20071651DOI Listing
April 2019
1 Read

Phytochemical composition, and cytotoxic, antioxidant, and antibacterial activity of the essential oil and methanol extract of .

Avicenna J Phytomed 2019 Mar-Apr;9(2):143-152

Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran.

Objective: In this study, our aim was to extract, and identify and quantify the chemical composition of essential oils of grown in Kerman, Iran. Moreover, cytotoxic, antioxidant and antimicrobial activity of the essential oil and methanol extract of aerial parts of were reported.

Materials And Methods: GC and GC/MS analysis were used for identifying and quantifying the essential oil components. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448547PMC
April 2019
1 Read

Clinicopathologic Characterization of Bilateral Testicular Germ Cell Tumors With Immunohistochemical Evaluation of Mismatch Repair and BRAF (V600E) Genes Mutations.

Int J Surg Pathol 2019 Apr 15:1066896919842939. Epub 2019 Apr 15.

1 Indiana University, Indianapolis, IN, USA.

The incidence of bilateral testicular germ cell tumor (TGCT) is 1% to 5%. Despite the high rate of treatment success, resistance to chemotherapy has a detrimental effect. Some studies found MMR and BRAF gene mutations to be associated with chemotherapy resistance, which has not been found by others. Read More

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http://dx.doi.org/10.1177/1066896919842939DOI Listing
April 2019
1 Read

Genetic profiling of rhabdomyosarcoma with clinicopathological and radiological correlation.

Can J Ophthalmol 2019 Apr 18;54(2):247-257. Epub 2018 May 18.

Pathology and Laboratory Medicine Department, King Khalid Eye Specialist Hospital, Riyadh, Saudi Arabia.

Objective: Orbital Rhabdomyosarcoma is a highly malignant tumor predominantly affecting children. Our study adds more understanding of this tumor to ophthalmologists from the clinicopathological, radiological and genetic aspects.

Design: A retrospective clinicopathological and radiological study of ocular rhabdomyosarcoma with genetic profiling. Read More

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http://dx.doi.org/10.1016/j.jcjo.2018.03.011DOI Listing
April 2019
1 Read

Embryonal carcinoma testis with extensive metastasis and IVC thrombosis.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):350-352

Department of Oncosurgery, Sahara Hospital, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/IJPM.IJPM_63_18DOI Listing
April 2019
1 Read

An update on the central nervous system manifestations of DICER1 syndrome.

Acta Neuropathol 2019 Apr 5. Epub 2019 Apr 5.

Department of Pathology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Bader 104, Boston, MA, 02115, USA.

DICER1 syndrome is a rare tumor predisposition syndrome with manifestations that predominantly affect children and young adults. The syndrome is typically caused by heterozygous germline loss-of-function DICER1 alterations accompanied on the other allele by somatic missense mutations occurring at one of a few mutation hotspots within the sequence encoding the RNase IIIb domain. DICER1 encodes a member of the microRNA biogenesis machinery. Read More

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http://dx.doi.org/10.1007/s00401-019-01997-yDOI Listing
April 2019
2 Reads

E2f1 regulates the induction of promyelocytic leukemia zinc finger transcription in neuronal differentiation of pluripotent P19 embryonal carcinoma cells.

Biochem Biophys Res Commun 2019 May 23;512(3):629-634. Epub 2019 Mar 23.

PhD Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Ph.D Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei, Taiwan. Electronic address:

During brain development, the expression of promyelocytic leukemia zinc finger (Plzf) in neural stem cells is precisely controlled to maintain the balance between neural stem cell self-renewal and differentiation. However, the mechanism underlying transcriptional regulation of Plzf in neural stem cell is still unclear. Herein, using P19 embryonal carcinoma cells as a model, we observed that Plzf expression was induced in the P19-derived embryonic bodies, which enrich neural stem-like cell populations, as demonstrated by the expression of neural stem cell markers, Nestin and Sox2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X193043
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http://dx.doi.org/10.1016/j.bbrc.2019.03.058DOI Listing
May 2019
2 Reads

Intratubular Teratoma: A Rare Form of Testicular Germ Cell Neoplasia.

Int J Surg Pathol 2019 Mar 24:1066896919836491. Epub 2019 Mar 24.

1 Northwell Health Lenox Hill Hospital, New York, NY, USA.

Germ cell neoplasia in situ is the initial manifestation for invasive germ cell tumor. Further progression will result in intratubular germ cell tumor with the majority being intratubular seminoma or intratubular embryonal carcinoma. Intratubular teratoma in the testis is exceptionally rare with no well-documented cases to our knowledge. Read More

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http://dx.doi.org/10.1177/1066896919836491DOI Listing
March 2019
1 Read
0.961 Impact Factor

[Testicular germ cell tumors: Histopathological and molecular features].

Bull Cancer 2019 Apr 21;106(4):328-341. Epub 2019 Mar 21.

Hôpital Foch, service d'anatomie et cytologie pathologiques, 40, rue Worth, 92150 Suresnes, France; Institut Curie, service de pathologie, 35, rue Dailly, 92240 Saint Cloud, France. Electronic address:

In 2016, the WHO classification of testicular germ cell tumors was revised considering advances in the understanding of their tumorigenesis and molecular features. This restructuring led to a division into two major groups with, on one hand, prepubertal-type tumors, not derived from germ cell neoplasia in situ (GCNIS), and on the other hand, postpubertal-type tumors, GCNIS-derived, which occur in youg men (seminoma and non seminomatous germ cell tumors - embryonal carcinoma, yolk sac tumor, teratoma and choriocarcinoma essentially). The term germ cell neoplasia in situ is consensually accepted as a new terminology for the precursor lesion. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.02.004DOI Listing
April 2019
1 Read

Targeting RNA helicase DDX3 in stem cell maintenance and teratoma formation.

Genes Cancer 2019 Feb;10(1-2):11-20

Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

DDX3 is an RNA helicase that has antiapoptotic properties, and promotes proliferation and transformation. Besides the role of DDX3 in transformed cells, there is evidence to indicate that DDX3 expression is at its highest levels during early embryonic development and is also expressed in germ cells of adults. Even though there is a distinct pattern of DDX3 expression during embryonic development and in adults, very little is known regarding its role in embryonic stem cells and pluripotency. Read More

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http://dx.doi.org/10.18632/genesandcancer.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420792PMC
February 2019
1 Read

Poor prognosis of retroperitoneal mixed extragonadal germ cell tumors in an HIV-infected man with severe immunosuppression and bilateral cryptorchidism: a case report.

Authors:
Ruili Li Hongjun Li

BMC Cancer 2019 Mar 18;19(1):244. Epub 2019 Mar 18.

Department of Radiology, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmen Wai, Fengtai District, Beijing, 100069, China.

Background: Nonseminomatous germ cell tumors (NSGCTs) represent one of the main groups of germ cell tumors (GCTs), and they have a more invasive course than seminomatous GCTs. Human immunodeficiency virus (HIV) positivity is considered to be a risk factor for testicular seminoma patients, but reports about HIV-infected individuals with NSGCTs are rare.

Case Presentation: We report a case of a retroperitoneal mixed extragonadal germ cell tumor in an HIV-infected man who has been diagnosed with bilateral cryptorchidism since birth. Read More

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http://dx.doi.org/10.1186/s12885-019-5456-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423750PMC
March 2019
1 Read

Cervical cancer in women aged 25 years or younger: a retrospective study.

Cancer Manag Res 2019 6;11:2051-2058. Epub 2019 Mar 6.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China,

Purpose: The incidence of cervical cancer in young women is increasing. This study aimed to analyze the clinicopathological characteristics, treatment, and prognoses of women aged ≤25 years with cervical cancer.

Patients And Methods: Medical record data of 60 cervical cancer patients aged ≤25 years treated at Peking Union Medical College Hospital between January 1986 and December 2017 were reviewed. Read More

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http://dx.doi.org/10.2147/CMAR.S195098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411317PMC
March 2019
1 Read

Cell-to-cell variation of chromosomal number in the adult testicular germ cell tumors: a comparison of chromosomal instability among histological components and its putative role in tumor progression.

Virchows Arch 2019 Mar 14. Epub 2019 Mar 14.

Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

By allelotyping analysis, we previously reported a putative progression pathway from germ cell neoplasia in situ (GCNIS) to seminoma, then to embryonal carcinoma in mixed-type testicular germ cell tumors (TGCTs), and detected that loss of heterozygosity events in seminoma components in mixed tumors were more frequent than those in pure seminomas. To elucidate a role of chromosomal instability in the progression of non-seminomatous germ cell tumor (NSGCT), we performed fluorescence in situ hybridization with centromeric probes for chromosomes 1, 7, 8, 12, 17, and X on a cohort of 52 TGCT cases with 103 histologically distinct components: 39 GCNIS lesions (16 and 23 in tumors with and without NSGCT components, respectively), 39 seminomas (27 as pure seminomas and 12 in mixed tumors), and 25 embryonal carcinomas. On a total component basis, both the mean copy number per tumor cell nucleus and the deviations from the modal number of all chromosomes examined significantly increased from GCNIS to seminoma, then to embryonal carcinoma with few exceptions. Read More

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http://dx.doi.org/10.1007/s00428-019-02560-6DOI Listing
March 2019
2 Reads

Shared and unique genomic structural variants of different histological components within testicular germ cell tumours identified with mate pair sequencing.

Sci Rep 2019 Mar 5;9(1):3586. Epub 2019 Mar 5.

Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Post-pubertal testicular germ-cell tumours (TGCTs) can present with a variety of distinct histologies which are nevertheless lineage related and often co-occurring. The exact lineage relationships and developmental pathways leading to the different histologies is debated. In order to investigate the relationship of histologic populations, mate-pair sequencing (MPseq) and exome sequencing (ExomeSeq) were conducted on different histological populations within the same tumour. Read More

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http://dx.doi.org/10.1038/s41598-019-39956-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400951PMC
March 2019
2 Reads

Distinct Metabolic Features of Seminoma and Embryonal Carcinoma Revealed by Combined Transcriptome and Metabolome Analyses.

J Proteome Res 2019 Apr 12;18(4):1819-1826. Epub 2019 Mar 12.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology , Chinese Academy of Sciences , Beijing 100101 , China.

Seminoma and embryonal carcinoma (EC), two typical types of testicular germ cell tumors (TGCTs), present significant differences in growth behavior, expression characteristics, differentiation potential, clinical features, therapy, and prognosis. The purpose of this study was to compare the distinctive or preference metabolic pathways between seminoma and EC. The Cancer Genome Atlas revealed that many genes encoding metabolic enzymes could distinguish between seminoma and EC. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00007DOI Listing
April 2019
4 Reads

Curcumin Induces Neural Differentiation of Human Pluripotent Embryonal Carcinoma Cells through the Activation of Autophagy.

Biomed Res Int 2019 21;2019:4378710. Epub 2019 Jan 21.

Laboratory of Cell-Based Assays and Innovations, School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, 111 University Avenue, Nakhon Ratchasima 30000, Thailand.

Curcumin is a natural polyphenolic compound, isolated from Curcuma longa, and is an important ingredient of Asian foods. Curcumin has revealed its strong activities of anti-inflammatory, antioxidant, and anticancer. The efficient amount of curcumin could induce differentiation of stem cells and promoted the differentiation of glioma-initiating cells; however, the mechanisms underlying neural induction of curcumin have not yet been revealed. Read More

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http://dx.doi.org/10.1155/2019/4378710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360631PMC
January 2019

Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Apr 31;127(4):309-317. Epub 2018 Dec 31.

Molecular Pathology Area, School of Dentistry, Universidad de La Republica (UDELAR), Montevideo, Uruguay.

Objectives: The aim of this study was to analyze the immunohistochemical expression of fatty acid synthase (FASN) and cyclooxygenase-2 (COX-2) in tooth germ (TG), ameloblastoma (AM), ameloblastic carcinoma (AC), ameloblastic fibroma (AF), and ameloblastic fibrosarcoma (AFS).

Study Design: Immunohistochemistry for FASN and COX-2 was performed in 10 TG, 44 AM, 10 AC, 9 AF, and 5 AFS specimens. The results were analyzed by using the immunoreactive score (IRS) and Kruskal-Wallis test followed by Dunn's post-test. Read More

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http://dx.doi.org/10.1016/j.oooo.2018.12.020DOI Listing
April 2019
2 Reads

Unedited microneurosurgery of a mixed germ cell tumor of the pineal region.

Surg Neurol Int 2018 24;9:262. Epub 2018 Dec 24.

International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: Germ cell tumors comprise a heterogeneous group of neoplasms, classified as germinomas and nongerminomatous germ cell tumors based on clinicopathological features. The nongerminomatous group of tumors includes embryonal carcinoma, endodermal sinus tumor (yolk sac tumor), choriocarcinoma, mature and immature teratoma, and mixed germ cell tumors with more than one element. While germinomas are radiation-sensitive tumors, all other tumors have less response to radiotherapy, and it is suggested that gross total resection improves their overall survival and tumor-free survival rates. Read More

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http://dx.doi.org/10.4103/sni.sni_357_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322164PMC
December 2018
2 Reads

Human Testis Phosphoproteome Reveals Kinases as Potential Targets in Spermatogenesis and Testicular Cancer.

Mol Cell Proteomics 2019 Mar 25;18(Suppl 1):S132-S144. Epub 2019 Jan 25.

From the ‡Lead Pharma BV, Pivot Park, Kloosterstraat 9, 5349 AB Oss, The Netherlands;

Spermatogenesis is a complex cell differentiation process that includes marked genetic, cellular, functional and structural changes. It requires tight regulation, because disturbances in any of the spermatogenic processes would lead to fertility deficiencies as well as disorders in offspring. To increase our knowledge of signal transduction during sperm development, we carried out a large-scale identification of the phosphorylation events that occur in the human male gonad. Read More

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http://www.mcponline.org/lookup/doi/10.1074/mcp.RA118.001278
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http://dx.doi.org/10.1074/mcp.RA118.001278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427237PMC
March 2019
17 Reads

SGTb regulates a surface localization of a guidance receptor BOC to promote neurite outgrowth.

Cell Signal 2019 Mar 9;55:100-108. Epub 2019 Jan 9.

Department of Molecular Cell Biology, Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea; Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Republic of Korea. Electronic address:

Neuritogenesis is a critical event for neuronal differentiation and neuronal circuitry formation during neuronal development and regeneration. Our previous study revealed a critical role of a guidance receptor BOC in a neuronal differentiation and neurite outgrowth. However, regulatory mechanisms for BOC signaling pathway remain largely unexplored. Read More

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http://dx.doi.org/10.1016/j.cellsig.2019.01.003DOI Listing
March 2019
4 Reads

New Anti-Cancer Strategies in Testicular Germ Cell Tumors.

Recent Pat Anticancer Drug Discov 2019 ;14(1):53-59

Institute of Endocrinology and Experimental Oncology of the CNR c / o Department of Molecular Medicine and Medical Biotechnology, School of Medicine and Surgery of Naples, University of Naples 'Federico II', Naples, Italy.

Background: The most common solid malignancy of young men aged 20 to 34 years is testicular germ cell tumor. In addition, the incidence of these tumors has significantly increased throughout the last years. Testicular germ cell tumors are classified into seminoma and nonseminoma germ cell tumors, which take in yolk sac tumor, embryonal cell carcinoma, choriocarcinoma, and teratoma. Read More

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http://www.eurekaselect.com/168893/article
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http://dx.doi.org/10.2174/1574892814666190111120023DOI Listing
January 2019
26 Reads

MicroRNA-135a-5p promotes neuronal differentiation of pluripotent embryonal carcinoma cells by repressing Sox6/CD44 pathway.

Biochem Biophys Res Commun 2019 Feb 31;509(2):603-610. Epub 2018 Dec 31.

From the Department of Molecular Neurobiology, Shaanxi Normal University, Xi'an, 710119, China. Electronic address:

MicroRNA-135a-5p has been reported to play a potential role in the generation of new neurons. However, the underlying targets of miR-135a-5p in regulating neuronal differentiation have been poorly understood. Our study recently has uncovered that Sox6 and CD44 genes were significantly downregulated during neuronal differentiation of P19 cells, a multipotent cell type. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.12.162DOI Listing
February 2019
2 Reads
2.297 Impact Factor

Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart.

Exp Oncol 2018 12;40(4):336-342

Amosov National Institute of Cardiovascular Surgery, Kyiv 02000, Ukraine.

Background: Tumors of the heart are uncommon and usually benign (in 93% cases myxomas are observed). More often secondary, metastatic tumors are detected in the heart, as a rule, at pronounced progression of the malignant neoplasm with multiple lesions of other internal organs (lung, pleura, liver, etc.). Read More

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December 2018
2 Reads

TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem-Like Cells in a Redox-Sensitive Manner.

Clin Cancer Res 2019 Mar 28;25(6):2001-2017. Epub 2018 Dec 28.

Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.

Purpose: Stem-like cancer cells, with characteristic self-renewal abilities, remain highly refractory to various clinical interventions. As such, stemness-inhibiting entities, such as tumor suppressor p53, are therapeutically pursued for their anticancer activities. Interestingly, similar implications for tumor suppressor TAp73 in regulating stemness features within stem-like cancer cells remain unknown. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3177DOI Listing
March 2019
4 Reads

Incidence of testicular tumor subtypes according to the updated WHO classification, North Rhine-Westphalia, Germany, 2008-2013.

Andrology 2018 Dec 21. Epub 2018 Dec 21.

Cancer Registry of North Rhine-Westphalia, Muenster, Germany.

Background: In 2016, the WHO introduced an updated classification for testicular tumors. The application of this updated classification to cancer registry data requires some recoding of tumors.

Objectives: The aim of this study was to provide up-to-date population-based incidence estimates of subtypes of testicular germ cell tumors (TGCT) according to the updated classification. Read More

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http://dx.doi.org/10.1111/andr.12565DOI Listing
December 2018
1 Read

5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells.

Int J Mol Sci 2018 Dec 21;20(1). Epub 2018 Dec 21.

Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, University Medical Center Eppendorf, 20246 Hamburg, Germany.

Despite high cure rates, about 20% of patients with advanced germ cell tumors (GCTs) fail cisplatin-based chemotherapy. High levels of DNA methylation have been identified in GCTs and linked to cisplatin resistance. Here, we examined the effects of DNA hypomethylating 5-azacitidine (5-aza) on two embryonal carcinoma cell lines (NCCIT, 2102Ep) and their cisplatin-resistant isogenic derivatives. Read More

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http://dx.doi.org/10.3390/ijms20010021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337423PMC
December 2018
5 Reads

Dynamic spatiotemporal patterns of alternative splicing of an F-actin scaffold protein, afadin, during murine development.

Gene 2019 Mar 17;689:56-68. Epub 2018 Dec 17.

Laboratory of Cell and Molecular Biology, Graduate School of Life Science, University of Hyogo, 3-2-1 Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, Japan; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida-honmachi, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

An F-actin scaffold protein, afadin, comprises two splice variants called l-afadin (a long isoform) and s-afadin (a short isoform). It is known that in adult tissues, l-afadin is ubiquitously expressed while s-afadin is restrictedly expressed in brain. In cultured cortical neurons, l-afadin potentiates axonal branching whereas s-afadin blocks axonal branching by functioning as a naturally occurring dominant-negative isoform that forms a heterodimer with l-afadin. Read More

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http://dx.doi.org/10.1016/j.gene.2018.12.020DOI Listing
March 2019
2 Reads

Correlation Between the Sites of Onset of Basal Cell Carcinoma and the Embryonic Fusion Planes in the Auricle.

Clin Med Insights Oncol 2018 7;12:1179554918817328. Epub 2018 Dec 7.

Advanced Technologies for Regenerative Medicine and Inductive Surgery Research Center, University of Pavia, Pavia, Italy.

Objectives: This study aims at the identification of the distribution of basal cell carcinomas (BCCs) in the auricle in correlation with the currently most credited sites of the embryonic fusion planes of the auricle.

Methods: An overall number of 69 patients with 72 BCCs of the auricle were enrolled in the study over a period of 14 years, from June 2003 to October 2017. All the cases underwent medical preoperative digital photography and the specific location of each BCC was coded on an original full-size anatomical diagram of the auricle derived from the reports by Streeter, Wood-Jones, Park, Porter, and Minoux showing the currently most credited sites of the embryonic fusion planes arbitrarily featured as two 5-mm-wide ribbon-like areas: (1) the hyoid-mandibular fusion plane (HM-FP) running from the upper margin of the tragus toward the concha and then deflecting toward the lower margin of the tragus and (2) the free ear fold-hyoid fusion plane (FEFH-FP) running from the cranial-most portion of the helix to the mid-portion of the ascending helix. Read More

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http://dx.doi.org/10.1177/1179554918817328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293364PMC
December 2018
9 Reads

Neuroglial Differentiation and Neoplasms in Testicular Germ Cell Tumors Lack Immunohistochemical Evidence of Alterations Characteristic of Their CNS Counterparts: A Study of 13 Cases.

Am J Surg Pathol 2019 Mar;43(3):422-431

Departments of Pathology.

Overgrowth of neuroglial tissue is rare in testicular germ cell tumors and mostly reported as isolated cases. We retrospectively reviewed 13 cases of testicular germ cell tumors from 2 institutions from 1995 to 2018. Hematoxylin and eosin slides were collected and reviewed. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001206DOI Listing
March 2019
4 Reads

Giving Birth After Fertility Sparing Treatment of Embrional Carcinoma Figo III C: Case Report and Literature Review.

Med Arch 2018 Nov;72(5):371-373

Department for Pathology, Policlinic for Laboratory Diagnostic, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.

Introduction: Malignant ovarian germ cell tumors (MOGCTs) account for 2-5% of all ovarian cancers and among them pure embryonal cell cancer is rare condition (1, 2, 3, 4).

Aim: To show successful pregnancy after unilateral salpingooopherectomy and chemotherapy in a girl with embryonal carcinoma of ovary (ECO).

Case Report: Patient had FIGO stage III c disease. Read More

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http://dx.doi.org/10.5455/medarh.2018.72.371-373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282920PMC
November 2018
3 Reads

Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.

J Cancer 2018 31;9(23):4440-4448. Epub 2018 Oct 31.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 in testicular germ cell tumors (TGCTs) is unclear at present. Read More

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http://dx.doi.org/10.7150/jca.25279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277652PMC
October 2018
3 Reads

Embryonal Origin of Metanephric Adenoma and its Differential Diagnosis.

Anticancer Res 2018 Dec;38(12):6663-6667

Department of Urology, Medical School, University of Pecs, Pecs, Hungary

Background/aim: The association of Wilms' tumor (WT), papillary renal cell tumor (PRCT) and mucinous tubular and spindle cell carcinoma (MTSCC) with embryonal rests has already been documented, but the cellular origin of metanephric adenoma (MA) is not yet known. The aim of this study was to understand their developmental evolution and find diagnostic markers.

Materials And Methods: CD57, KRT7, AMACR, SCEL, WT1 and CDH17 expression was analysed by immunohistochemistry in the four types of tumors and the associated pre-neoplastic lesions. Read More

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http://dx.doi.org/10.21873/anticanres.13033DOI Listing
December 2018
2 Reads

The MicroRNA-371 Family as Plasma Biomarkers for Monitoring Undifferentiated and Potentially Malignant Human Pluripotent Stem Cells in Teratoma Assays.

Stem Cell Reports 2018 Dec 29;11(6):1493-1505. Epub 2018 Nov 29.

Department of Pathology, Laboratory for Experimental Patho-Oncology, Erasmus MC Cancer Institute, Be-432A, PO Box 2040, 3000 CA Rotterdam, the Netherlands. Electronic address:

Predicting developmental potency and risk of posttransplantation tumor formation by human pluripotent stem cells (hPSCs) and their derivatives largely rely on classical histological analysis of teratomas. Here, we investigated whether an assay based on microRNAs (miRNA) in blood plasma is able to detect potentially malignant elements. Several hPSCs and human malignant germ cell tumor (hGCT) lines were investigated in vitro and in vivo after mouse xenografting. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22136711183044
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http://dx.doi.org/10.1016/j.stemcr.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294243PMC
December 2018
14 Reads

CD147 Is a Novel Chemotherapy or Prevention Target in Melanoma.

J Investig Dermatol Symp Proc 2018 Dec;19(2):S91-S93

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

CD147, also named as BSG, was first identified from F9 embryonal carcinoma cells (Miyauchi et al., 1990) and the human BSG locus on chromosome 19p13.3 containing 10 exons (Belton et al. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10870024183001
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http://dx.doi.org/10.1016/j.jisp.2018.10.001DOI Listing
December 2018
20 Reads

Intraarterial indocyanine green (ICG) fluorescence augmentation by marking embryonal resection areas in colorectal surgery: a feasibility study in a porcine model.

Minim Invasive Ther Allied Technol 2018 Nov 15:1-5. Epub 2018 Nov 15.

a Department of General, Visceral, and Transplantation Surgery, Hospital of the LMU Munich , Ludwig-Maximilians-University (LMU) , Munich , Germany.

Aim: In this pilot animal study we examined whether it is possible to visualize the embryonal resection layers by using intraarterial indocyanine green (ICG) staining when performing total mesorectal excision (TME) for carcinoma of the rectum.

Material And Methods: We injected ICG into the inferior mesenteric artery (AMI) of four swines to see whether the watershed area of the arterial supply zone can be sufficiently visualized by fluorescence imaging in order to mark the right dissection area along the fascia parietalis before and during resection.

Results: We observed a fluorescence signal in all the supplied areas of AMI but not in other parts of the abdominal cavity or other organs. Read More

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http://dx.doi.org/10.1080/13645706.2018.1544568DOI Listing
November 2018
3 Reads

DNA methylation profiling as a tool for testicular germ cell tumors subtyping.

Epigenomics 2018 Dec 12;10(12):1511-1523. Epub 2018 Nov 12.

Cancer Biology & Epigenetics Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.

Aim: Assess differential patterns of selected five genes' promoter methylation among testicular germ cell tumors (TGCT) subtypes.

Materials & Methods:  CRIPTO, HOXA9, MGMT, RASSF1A and SCGB3A1 promoter methylation levels were evaluated by quantitative methylation-specific PCR in 161 TGCT and 16 controls. Associations between clinicopathological parameters and promoter methylation levels were assessed, and receiver operating characteristics curve analysis was performed. Read More

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https://www.futuremedicine.com/doi/10.2217/epi-2018-0034
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http://dx.doi.org/10.2217/epi-2018-0034DOI Listing
December 2018
39 Reads

Malignant Spinal Cord Compression Syndrome as an Initial Presentation of Testicular Cancer.

Case Rep Oncol Med 2018 8;2018:5757434. Epub 2018 Oct 8.

Centro Universitario Contra el Cáncer, University Hospital "Dr. José Eleuterio González" and Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Malignant spinal cord compression syndrome (MSCCS) occurs in 2.5 to 5% of all oncological patients. In 20% of the cases, it is the initial manifestation. Read More

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https://www.hindawi.com/journals/crionm/2018/5757434/
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http://dx.doi.org/10.1155/2018/5757434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196924PMC
October 2018
22 Reads

Overexpression of the Pluripotent Stem Cell Marker Podocalyxin in Prostate Cancer.

Anticancer Res 2018 Nov;38(11):6361-6366

Department of Pathology, Wayne State University School of Medicine, Detroit, MI, U.S.A.

Background/aim: Podocalyxin, a member of the CD34 family of cell surface sialomucins, is overexpressed in human embryonal carcinoma cell lines, as well as in several cancer types, and is associated with poor prognosis. Podocalyxin variants are associated with an increased risk and aggressiveness of prostate cancer. Herein podocalyxin protein expression in prostate cancer was characterized. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.12
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http://dx.doi.org/10.21873/anticanres.12994DOI Listing
November 2018
16 Reads

RHOA activity in expanding blastocysts is essential to regulate HIPPO-YAP signaling and to maintain the trophectoderm-specific gene expression program in a ROCK/actin filament-independent manner.

Mol Hum Reprod 2019 Feb;25(2):43-60

Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.

Study Question: What molecular signals are required to maintain the functional trophectoderm (TE) during blastocyst expansion of the late stage of preimplantation development?

Summary Answer: The activity of ras homology family member A (RHOA) GTPases is necessary to retain the expanded blastocyst cavity and also to sustain the gene expression program specific to TE.

What Is Known Already: At the early stages of preimplantation development, the precursor of the TE lineage is generated through the molecular signals that integrate RHOA, RHO-associated coiled-coil containing protein kinase (ROCK), the apicobasal cell polarity, and the HIPPO-Yes-associated protein (YAP) signaling pathway. By contrast, molecular mechanisms regulating the maintenance of the TE characteristics at the later stage, which is crucial for blastocyst hatching and implantation, are scarcely understood. Read More

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https://academic.oup.com/molehr/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/molehr/gay048DOI Listing
February 2019
8 Reads

Aryl hydrocarbon receptor mediates the cardiac developmental toxicity of EOM from PM in P19 embryonic carcinoma cells.

Chemosphere 2019 Feb 23;216:372-378. Epub 2018 Oct 23.

Medical College of Soochow University, Suzhou, China. Electronic address:

Ambient fine particulate matter (PM) has been found to be associated with congenital heart defects, but the molecular mechanisms remain to be elucidated. Our previous study revealed that extractable organic matter (EOM) from PM exerted cardiac developmental toxicity in zebrafish embryos. The aim of the current study is to explore the effects of EOM on cardiac differentiation of P19 mouse embryonic carcinoma stem cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535183202
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http://dx.doi.org/10.1016/j.chemosphere.2018.10.160DOI Listing
February 2019
3 Reads

Cytokeratin 7, inhibin, and p63 in testicular germ cell tumor: superior markers of choriocarcinoma compared to β-human chorionic gonadotropin.

Hum Pathol 2019 Feb 22;84:254-261. Epub 2018 Oct 22.

Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA. Electronic address:

Choriocarcinoma can be difficult to differentiate from other subtypes of testicular germ cell tumor and can occur unexpectedly in a distant, late metastasis. The aim of this investigation was to identify a marker superior to β-human chorionic gonadotropin (β-hCG) for choriocarcinoma. Sixty-two primary and metastatic testicular germ cell tumors (27 choriocarcinomas, 19 yolk sac tumors, 29 embryonal carcinomas, 28 seminomas, 22 teratomas, 3 epithelioid trophoblastic tumors [ETTs]) were analyzed for immunohistochemical expression of cytokeratin 7 (CK7), inhibin, p63, and β-hCG. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183039
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http://dx.doi.org/10.1016/j.humpath.2018.10.007DOI Listing
February 2019
11 Reads
2.770 Impact Factor

Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report.

Onco Targets Ther 2018 12;11:6853-6862. Epub 2018 Oct 12.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,

Malignant mixed ovarian germ cell tumors are very rare, accounting for ~5.3% of all malignant ovarian germ cell tumors (MOGCTs), with a very high degree of malignancy. The treatment of patients with persistent, refractory, or platinum-resistant MOGCT is not well defined. Read More

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https://www.dovepress.com/malignant-mixed-ovarian-germ-cell-
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http://dx.doi.org/10.2147/OTT.S176854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190639PMC
October 2018
5 Reads

Metabolic profile and differentiation potential of extraembryonic endoderm-like cells.

Cell Death Discov 2018 26;4:42. Epub 2018 Sep 26.

1Department of Biology, Collaborative Graduate Specialization in Developmental Biology, The University of Western Ontario, London, ON Canada.

Glucose metabolism has a crucial role for providing substrates required to generate ATP and regulate the epigenetic landscape. We reported that F9 embryonal carcinoma stem-like cells require cytosolic reactive oxygen species to differentiate into extraembryonic endoderm; however, mitochondrial sources were not examined. To extend these studies, we examined the metabolic profile of early and late-passage F9 cells, and show that their ability to differentiate is similar, even though each population has dramatically different metabolic profiles. Read More

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http://www.nature.com/articles/s41420-018-0102-1
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http://dx.doi.org/10.1038/s41420-018-0102-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158286PMC
September 2018
19 Reads

Clinicopathological Characteristics of Urinary Bladder Tumors in Korean Patients 20 Years or Younger.

J Korean Med Sci 2018 Oct 13;33(40):e242. Epub 2018 Aug 13.

Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

Background: To investigate the clinicopathological characteristics of urinary bladder tumors, a rare malignancy, in patients 20 years or younger.

Methods: Using a retrospective chart review among patients who received bladder surgery at 2 institutions between July 1996 and January 2013, we analyzed the clinicopathological characteristics of urinary bladder tumors in 21 pediatric patients (male:female = 4.25:1. Read More

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http://dx.doi.org/10.3346/jkms.2018.33.e242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159107PMC
October 2018
5 Reads

Seminoma component of mixed testicular germ cell tumor shows a higher incidence of loss of heterozygosity than pure-type seminoma.

Hum Pathol 2019 Feb 25;84:71-80. Epub 2018 Sep 25.

Department of Basic Pathology, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.

Using analysis of allelic loss (loss of heterozygosity [LOH]), we previously reported a putative progression pathway from germ cell neoplasia in situ (GCNIS) to seminoma and then to embryonal carcinoma in mixed-type testicular germ cell tumors. To identify the genetic backgrounds related to the progression of nonseminomatous germ cell tumor, patterns of LOH were studied in seminoma components in mixed tumors (18 cases), pure seminomas (20 cases), and coexisting GCNIS lesions. Each tumor was assessed for LOH at 22 polymorphic loci located on 12 chromosomal arms: 3q, 5q, 6p, 9p, 10q, 11p, 12p, 12q, 13q, 17p, 17q, and 18q. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.09.007DOI Listing
February 2019
3 Reads

Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells.

Cell Death Dis 2018 Sep 24;9(10):990. Epub 2018 Sep 24.

Department of Pathology, Dalhousie University, Halifax, NS, Canada.

Cancer cells with a less differentiated stem-like phenotype are more resistant to therapeutic manipulations than their differentiated counterparts, and are considered as one of the main causes of cancer persistence and relapse. As such, induction of differentiation in cancer stem-like cells (CSLCs) has emerged as an alternative strategy to enhance the efficacy of anticancer therapies. CSLCs are metabolically distinct from differentiated cells, and any aberration from the intrinsic metabolic state can induce differentiation of CSLCs. Read More

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http://dx.doi.org/10.1038/s41419-018-0997-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155240PMC
September 2018
10 Reads