102,998 results match your criteria Electrophysiology


Left Atrial Appendage Closure Device Implantation in Patients with Prior Intracranial Hemorrhage.

Heart Rhythm 2018 Nov 19. Epub 2018 Nov 19.

Section of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

Background: The Watchman™ device (Boston Scientific, MN), used for left atrial appendage closure (LAAC) was approved for stroke prevention in patients with atrial fibrillation (AF) and an appropriate rationale to avoid long-term oral anticoagulation. Patients with AF and prior intracranial hemorrhage (ICH) were excluded from clinical trials due to perceived risks of peri-operative anticoagulation.

Objective: We studied the efficacy and safety of LAAC using Watchman™ in patients with AF and prior ICH. Read More

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November 2018

Safety of Sports for Young Patients With Implantable Cardioverter-Defibrillators.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006305

Yale University School of Medicine, New Haven, CT (J.D., C.B., L.S., F.L., R.J.L.).

Background: Despite safety concerns, many young patients with implantable cardioverter-defibrillators (ICDs) participate in sports. We undertook a prospective, multinational registry to determine the incidence of serious adverse events because of sports participation. The primary end points were death or resuscitated arrest during sports or injury during sports because of arrhythmia or shock. Read More

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November 2018

Postural orthostatic tachycardia syndrome (POTS) in teens: A guide for behavior change to manage symptoms.

Pacing Clin Electrophysiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Pediatrics, Baylor College of Medicine, Houston, TX.

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December 2018

Catheter ablation in ASymptomatic PEDiatric patients with ventricular preexcitation: results from the multicenter "CASPED" study.

Clin Res Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Electrophysiology, German Heart Center Munich, Munich, Germany.

Background: As there are limited data about the clinical practice of catheter ablation in asymptomatic children and adolescents with ventricular preexcitation on ECG, we performed the multicenter "CASPED" (Catheter ablation in ASymptomatic PEDiatric patients with Ventricular Preexcitation) study.

Methods And Results: In 182 consecutive children and adolescents aged between 8 and 18 years (mean age 12.9 ± 2. Read More

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December 2018
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Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients.

Front Physiol 2018 21;9:1575. Epub 2018 Nov 21.

Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, Netherlands.

Sodium glucose cotransporter 2 inhibitors (SGLT2i) are the first antidiabetic compounds that effectively reduce heart failure hospitalization and cardiovascular death in type 2 diabetics. Being explicitly designed to inhibit SGLT2 in the kidney, SGLT2i have lately been investigated for their off-target cardiac actions. Here, we review the direct effects of SGLT2i Empagliflozin (Empa), Dapagliflozin (Dapa), and Canagliflozin (Cana) on various cardiac cell types and cardiac function, and how these may contribute to the cardiovascular benefits observed in large clinical trials. Read More

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November 2018

Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations.

Front Physiol 2018 21;9:1406. Epub 2018 Nov 21.

Department of Biology, University of Waterloo, Waterloo, ON, Canada.

The appearance of voltage-gated, sodium-selective channels with rapid gating kinetics was a limiting factor in the evolution of nervous systems. Two rounds of domain duplications generated a common 24 transmembrane segment (4 × 6 TM) template that is shared amongst voltage-gated sodium (Na1 and Na2) and calcium channels (Ca1, Ca2, and Ca3) and leak channel (NALCN) plus homologs from yeast, different single-cell protists (heterokont and unikont) and algae (green and brown). A shared architecture in 4 × 6 TM channels include an asymmetrical arrangement of extended extracellular L5/L6 turrets containing a 4-0-2-2 pattern of cysteines, glycosylated residues, a universally short III-IV cytoplasmic linker and often a recognizable, C-terminal PDZ binding motif. Read More

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November 2018

Association of progressive thoracic aortic calcification with future cardiovascular events and all-cause mortality: ability to improve risk prediction? Results of the Heinz Nixdorf Recall (HNR) study.

Eur Heart J Cardiovasc Imaging 2018 Dec 1. Epub 2018 Dec 1.

Institute of Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, Holsterhauser Str. 55, Essen, Germany.

Aims: Thoracic aortic calcification (TAC) is measured by computed tomography (CT). We investigated the association of TAC-progression with incident cardiovascular (CV) events and all-cause mortality in a population-based cohort and to determine its predictive value for these endpoints.

Methods And Results: In 3080 participants (45-74 years, 53. Read More

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December 2018

Real-time magnetic resonance imaging-guided cardiac electrophysiology: the long road to clinical routine.

Eur Heart J Cardiovasc Imaging 2018 Nov 30. Epub 2018 Nov 30.

Department of Internal Medicine I, University Hospital Wuerzburg, Oberduerrbacher Str. 6 97080 Wuerzburg, Germany.

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November 2018

Testosterone Deprivation Intensifies Cognitive Decline in Obese Male Rats Via Glial Hyperactivity, Increased Oxidative Stress, and Apoptosis in Both Hippocampus and Cortex.

Acta Physiol (Oxf) 2018 Dec 3:e13229. Epub 2018 Dec 3.

Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Aim: The study hypothesized that testosterone deprivation aggravates cognitive decline in obesity through increasing oxidative stress, glial activation and apoptosis.

Methods: Male Wistar rats (n=24) were fed with either normal-diet (ND) or HFD for 24 weeks. At week 13, ND-fed rats and HFD-fed rats were randomly assigned to two subgroups to receive either a sham-operation or bilateral-orchiectomy (ORX). Read More

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December 2018

Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity.

J Cell Mol Med 2018 Dec 3. Epub 2018 Dec 3.

Heart Health Center, East Hospital, Tongji University School of Medicine, Shanghai, China.

Nucleoporins (Nups) are known to be functional in nucleo-cytoplasmic transport, but the roles of nucleoporins in nonproliferating cells, such as cardiac myocytes, are still poorly understood. In this study, we report that Nup107 regulates cardiac bioelectricity by controlling the nucleo-cytoplasmic trafficking of Scn5a mRNA. Overexpression of Nup107 induced the protein expression of Scn5a rather than that of other ion channels, with no effects of their mRNA levels. Read More

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December 2018

Burnout and work-life balance among pediatric cardiologists: A single center experience.

Congenit Heart Dis 2018 Dec 2. Epub 2018 Dec 2.

Division of Pediatric Cardiology, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia.

Background: Physicians are exposed to workplace factors that may result in acute or chronic stress resulting in burnout. This may impact the productivity and result in suboptimal patient care practices.

Methods: We surveyed pediatric cardiology attending physicians at our institution to assess their perception of burnout and work-life balance using the Maslach Burnout Inventory and the Areas of Work-Life Survey. Read More

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December 2018
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A specific olfactory cortico-thalamic pathway contributing to sampling performance during odor reversal learning.

Brain Struct Funct 2018 Dec 1. Epub 2018 Dec 1.

Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY, 10962, USA.

A growing body of evidence shows that olfactory information is processed within a thalamic nucleus in both rodents and humans. The mediodorsal thalamic nucleus (MDT) receives projections from olfactory cortical areas including the piriform cortex (PCX) and is interconnected with the orbitofrontal cortex (OFC). Using electrophysiology in freely moving rats, we recently demonstrated the representation of olfactory information in the MDT and the dynamics of functional connectivity between the PCX, MDT and OFC. Read More

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December 2018
1 Read

Nonpolar residues in the presumptive pore-lining helix of mechanosensitive channel MSL10 influence channel behavior and establish a nonconducting function.

Plant Direct 2018 Jun 5;2(6). Epub 2018 Jun 5.

Department of Biology and Center for Engineering MechanoBiology, Washington University in Saint Louis, Saint Louis, Missouri.

Mechanosensitive (MS) ion channels provide a universal mechanism for sensing and responding to increased membrane tension. MscS-like (MSL) 10 is a relatively well-studied MS ion channel from that is implicated in cell death signaling. The relationship between the amino acid sequence of MSL10 and its conductance, gating tension, and opening and closing kinetics remains unstudied. Read More

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Remote Monitoring of Atrial High Rate Episodes in Pacemaker Patients. The Rapid Study Design.

J Atr Fibrillation 2018 Aug 31;11(2):2075. Epub 2018 Aug 31.

Departmental Unit of Electrophysiology, Evaluation and Treatment of Arrhythmias, Monaldi Hospital, Naples, Italy.

Background: Remote Monitoring (RM) has been introduced for several years and nowadays most pacemakers are equipped with such a technology. RM can provide early detection of high atrial rate episodes (AHREs) onset and enable prompt medical intervention. However, there are still little data on the clinical reactions triggered by the AHRE detected by RM of pacemaker recipients and on their possible benefit on patients' outcome. Read More

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Atrial Fibrillation and Objective Sleep Quality by Slow Wave Sleep.

J Atr Fibrillation 2018 Aug 31;11(2):2031. Epub 2018 Aug 31.

Cardiovascular Division, Department of Medicine, University of Virginia.

Background: Self-reported poor sleep quality has been suggested in patients with AF. Slow wave sleep (SWS) is considered the most restorative sleep stage and represents an important objective measure of sleep quality. The aim of this study was to compare quantity of SWS between patients with and without AF. Read More

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August 2018
2 Reads

Electrocortical Responses to Emotional Stimuli in Psychotic Disorders: Comparing Schizophrenia Spectrum Disorders and Affective Psychosis.

Front Psychiatry 2018 16;9:586. Epub 2018 Nov 16.

Department of Psychiatry, Stony Brook University, Stony Brook, NY, United States.

Emotion dysfunction has long been considered a cardinal feature across psychotic disorders, including schizophrenia and affective psychosis. However, few studies have used objective markers of emotional function to compare psychotic disorders to one another, and fewer studies have examined such markers within a longitudinal framework. Here, we examine one objective marker of emotional responsivity, the late positive potential (LPP), which is a centro-parietal event-related potential (ERP) that tracks the dynamic allocation of attention to emotional vs. Read More

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November 2018

Correlation of compound muscle action potential generated by donor nerves with the recovery of elbow flexion in Oberlin transfer in brachial plexus injury.

Indian J Plast Surg 2018 May-Aug;51(2):137-144

Department of Plastic Surgery, Bombay Hospital and Institute of Medical Sciences, Mumbai, Maharashtra, India.

Objective: To study the correlation of compound muscle action potential of donor nerves with the recovery of elbow flexion in Oberlin transfer in brachial plexus injury.

Introduction: Distal nerve transfer using motor fascicle of ulnar or median nerve to restore elbow flexion is a part of reconstructive surgery after upper brachial plexus injury, first described by Oberlin . However, one of the most critical influences on functional outcome is number of functioning motor axons in donor fascicle which is reflected by its compound muscle action potential. Read More

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December 2018

Ventricular Endocardial Tissue Geometry Affects Stimulus Threshold and Effective Refractory Period.

Biophys J 2018 Nov 9. Epub 2018 Nov 9.

Department of Bioengineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom. Electronic address:

Background: Understanding the biophysical processes by which electrical stimuli applied to cardiac tissue may result in local activation is important in both the experimental and clinical electrophysiology laboratory environments, as well as for gaining a more in-depth knowledge of the mechanisms of focal-trigger-induced arrhythmias. Previous computational models have predicted that local myocardial tissue architecture alone may significantly modulate tissue excitability, affecting both the local stimulus current required to excite the tissue and the local effective refractory period (ERP). In this work, we present experimental validation of this structural modulation of local tissue excitability on the endocardial tissue surface, use computational models to provide mechanistic understanding of this phenomena in relation to localized changes in electrotonic loading, and demonstrate its implications for the capture of afterdepolarizations. Read More

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November 2018

Anthelmintic drug actions in resistant and susceptible C. elegans revealed by electrophysiological recordings in a multichannel microfluidic device.

Int J Parasitol Drugs Drug Resist 2018 Dec 30;8(3):607-628. Epub 2018 Oct 30.

Institute of Neuroscience, University of Oregon, 1254 University of Oregon, Eugene, OR, 97403-1254, USA. Electronic address:

Many anthelmintic drugs used to treat parasitic nematode infections target proteins that regulate electrical activity of neurons and muscles: ion channels (ICs) and neurotransmitter receptors (NTRs). Perturbation of IC/NTR function disrupts worm behavior and can lead to paralysis, starvation, immune attack and expulsion. Limitations of current anthelmintics include a limited spectrum of activity across species and the threat of drug resistance, highlighting the need for new drugs for human and veterinary medicine. Read More

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December 2018

Morphological determinators of platelet activation status in patients with atrial fibrillation.

Int J Cardiol 2018 Nov 17. Epub 2018 Nov 17.

Department of Electrophysiology, Heart Center Leipzig, Germany.

Background: Stage of platelet activation is an important modulator of stroke risk associated with atrial fibrillation (AF). However, factors determining such activation status of thrombocytes in patients with AF are still not well studied.

Methods And Results: We enrolled 83 patients (mean age 61 ± 10 years, 61% male, mean CHADS-VASc 2. Read More

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November 2018

Hematological and psychophysiological correlates of anomalous information reception in mediums: A preliminary exploration.

Explore (NY) 2018 Aug 2. Epub 2018 Aug 2.

Windbridge Institute, 1517 N Wilmot Rd #254, Tucson, Arizona, USA.

Context: Modern research with mediums-individuals who regularly experience and report communication from the deceased-includes investigations of mediums' accuracy, psychology, phenomenology, and electrophysiology and the therapeutic potential of mediumship readings for the bereaved. Anecdotal reports imply that chronic medical problems may be a serious concern for mediums.

Objective: The aim of this study was two-fold: (I) to systematically investigate the hematological and psychophysiological correlates of anomalous information reception (AIR, the reporting of accurate and specific information about the deceased in the absence of prior knowledge, feedback, or deceptive means) and (II) to compare the reported health issues of mediums and non-mediums. Read More

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An optimized and automated approach to quantifying channelrhodopsin photocurrent kinetics.

Anal Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01520, USA. Electronic address:

Channelrhodopsins are light-activated ion channels that enable targetable activation or inhibition of excitable cells with light. Ion conductance can generally be described by a four step photocycle, which includes two open and two closed states. While a complete understanding of channelrhodopsin function cannot be understood in the absence of kinetic modeling, model fitting requires manual fitting, which is laborious and technically complicated for non-experts. Read More

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November 2018
2 Reads

Extracellular matrix-based intracortical microelectrodes: Toward a microfabricated neural interface based on natural materials.

Microsyst Nanoeng 2015 29;1(1). Epub 2015 Jun 29.

Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA.

Extracellular matrix (ECM)-based implantable neural electrodes (NEs) were achieved using a microfabrication strategy on natural-substrate-based organic materials. The ECM-based design minimized the introduction of non-natural products into the brain. Further, it rendered the implants sufficiently rigid for penetration into the target brain region and allowed them subsequently to soften to match the elastic modulus of brain tissue upon exposure to physiological conditions, thereby reducing inflammatory strain fields in the tissue. Read More

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Mechanisms of Etomidate-Mediated Decrease of Spontaneous Spike Activity of Mouse Cerebellar Purkinje Cells in vivo.

Pharmacology 2018 Dec 5;103(1-2):82-92. Epub 2018 Dec 5.

Key Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji,

Etomidate is an imidazole, nonbarbiturate hypnotic agent that is increasingly used in procedural sedation. However, the effects of etomidate on the spontaneous activity of cerebellar Purkinje cells (PCs) in living mouse have not been fully understood. In this study, we investigated the effects of etomidate on the spontaneous simple spike (SS) activity of PCs in urethane-anesthetized mice by cell-attached recording and pharmacological methods. Read More

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December 2018
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High frequency neuronal oscillatory abnormalities in the phospholipase C-β1 knockout mouse model of schizophrenia.

Int J Neuropsychopharmacol 2018 Dec 4. Epub 2018 Dec 4.

Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Melbourne Brain Centre, Parkville, Victoria, Australia.

Background: Schizophrenia is a complex neuropsychiatric disorder characterised by psychoses, socioaffective disturbances and cognitive deficits. The phosphodiesterase enzyme phospholipase C-β1 (PLC-β1) has been reported to be reduced in post-mortem tissue of schizophrenia patients. Dysregulation of neuronal oscillations, particularly those in the higher frequency range, such as beta (12-30 Hz) and gamma (30-80 Hz), are also associated with this disorder. Read More

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December 2018
2 Reads

Fluoxetine reverses brain radiation and temozolomide-induced anxiety and spatial learning and memory defect in mice.

J Neurophysiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, China.

Radiation therapy and concomitant temozolomide chemotherapy are commonly used in treatment of brain tumors, but they may also result in behavioral impairments such as anxiety and cognitive deficit. The present study sought to investigate the effect of fluoxetine on the behavioral impairments caused by radiation and temozolomide treatment. C57BL/6J mice were subjected to a single cranial radiation followed by 6-week cyclic temozolomide administration, and then treated with chronic administration of fluoxetine. Read More

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December 2018
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Enhanced visual experience rehabilitates the injured brain in Xenopus tadpoles in an NMDAR-dependent manner.

J Neurophysiol 2018 Dec 5. Epub 2018 Dec 5.

Scripps Research Institute, United States.

Traumatic brain injuries introduce functional and structural circuit deficits that must be repaired for an organism to regain function. We developed an injury model in which Xenopus laevis tadpoles are given a penetrating stab wound that damages the optic tectal circuit and impairs visuomotor behavior. In tadpoles, as in other systems, injury induces neurogenesis. Read More

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December 2018
1 Read

Authors reply.

Turk Kardiyol Dern Ars 2018 Dec;46(8):741

Division of Arrhythmia and Electrophysiology, Department of Cardiology, University of Health Sciences, Yuksek Ihtisas Heart-Education and Research Hospital, Ankara, Turkey.

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December 2018

Feasibility and Utility of Intraoperative Epicardial Scar Characterization During Left Ventricular Assist Device Implantation for Destination Therapy.

J Cardiovasc Electrophysiol 2018 Dec 5. Epub 2018 Dec 5.

Center for Arrhythmia Care, University of Chicago Medicine.

Introduction: Ventricular arrhythmias (VA) after left ventricular assist device (LVAD) placement are associated with increased morbidity and mortality. We sought to assess epicardial voltage characteristics at the time of LVAD implantation and investigate relationships between scar burden and post-implant VA.

Methods And Results: Consecutive patients underwent open-chest epicardial electroanatomic mapping immediately prior to LVAD implantation. Read More

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December 2018

Percutaneous lead extraction and repositioning: An effective and safe therapeutic strategy for early ventricular lead perforation with dislocation both inside and outside the pericardial sac following a cardiac device implantation.

J Cardiovasc Electrophysiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiology, Hippokration General Hospital, 114 Vasilisis Sofias str, Athens, Greece.

Introduction: Cardiac perforation of the right ventricle associated with pacemaker or implantable cardioverter-defibrillator (ICD) leads' implantation is an uncommon, albeit potentially life-threatening, complication. The aim of this study is to further identify the optimal therapeutic strategy especially when lead dislocation has occurred outside the pericardial sac.

Methods And Results: The study population included 10 consecutive patients (6 female, mean age: 66. Read More

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December 2018

Comparative analysis for five fixations of Pauwels-I by the biomechanical finite-element method.

J Invest Surg 2018 Dec 5:1-10. Epub 2018 Dec 5.

a Orthopedics Dept. of 1st Affiliated Hospital , GuangZhou Medical University , GuangDong , China.

Background: Little is known about how biomechanics govern the five fixtures such as DHS, MLS, DHS + LS, LP, and HA are accepted as common therapeutic techniques.

Aims And Objectives: A series of numerical models for a femoral neck fracture of Pauwels-I will be constructed by innovative approach of finite element in order to determine the most optimized option in comparison with biomechanical performance.

Method: Twenty sets of computer tomography scanned femora were imported onto Mimics to extract 3 D models; these specimens were transferred to Geomagic-Studio for a simulative osteotomy and kyrtograph; then, they underwent UG to fit simulative solid models; 5 sorts of fixture were then expressed by Pro-Engineer virtually. Read More

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December 2018

Inappropriate disabling of an ICD noise-detection algorithm in pacemaker-dependent patients.

Pacing Clin Electrophysiol 2018 Dec 4. Epub 2018 Dec 4.

Bordeaux University Hospital (CHU), Cardio-thoracic unit, F-33600 Pessac, France.

SecureSense™ is an ICD algorithm that differentiates lead-related oversensing from VT/VF by continuous comparison between the near field (NF) and the far field (FF) EGM. If lead noise is identified, inappropriate therapy is withheld. Undersensing on the FF channel could result in inappropriate inhibition of life-saving therapy. Read More

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December 2018

Transvenous lead extraction, only once or repeatable?

Pacing Clin Electrophysiol 2018 Dec 4. Epub 2018 Dec 4.

Division of Arrhythmia and Electrophysiology, Department of Cardiology, University of Health Sciences, Yuksek Ihtisas Heart-Education and Research Hospital, Ankara, Turkey.

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December 2018

Optimizing resynchronization pacing in the failing systemic right ventricle.

Pacing Clin Electrophysiol 2018 Dec 4. Epub 2018 Dec 4.

Section of Pediatric Cardiology, The Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI, 48201.

Cardiac resynchronization pacing therapy (CRT) can be a potentially effective modality to delay the need for heart transplantation and improve the clinical status among patients with heart failure. Unfortunately, published guidelines and studies with an over-reliance on ejection fraction (EF) and QRS duration as markers for efficacy are frequently not applicable to the ever-growing number of adults with repaired congenital heart defects (CHD), some with systemic anatomical right ventricles as well as pre-existing pacemakers. In this issue of Pacing and Clinical Electrophysiology, Moore et al introduce a novel pre-selection screening process to optimize paced contractility among patients with repaired CHD and systemic right ventricles. Read More

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December 2018
3 Reads

Digitalis Promotes Ventricular Arrhythmias in Flecainide- and Ranolazine-Pretreated Hearts.

Cardiovasc Toxicol 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiology II - Electrophysiology, University Hospital Münster, Münster, Germany.

A post hoc analysis of the PALLAS trial suggested life-threatening interactions of digitalis and dronedarone. Thus, there is concern about an interplay between digitalis and other drugs that influence cardiac electrophysiology. We therefore investigated the interaction between digitalis and flecainide or ranolazine. Read More

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December 2018

Osteoarthritis pain: What are we learning from animal models?

Best Pract Res Clin Rheumatol 2017 Oct 26;31(5):676-687. Epub 2018 Apr 26.

Department of Medicine, Division of Rheumatology, Rush University Medical Center, 1611 W Harrison Street, Suite 510, Chicago, IL, 60612, United States. Electronic address:

All experimental models of osteoarthritis (OA)-like joint damage are accompanied by behaviors indicative of pain. In experimental knee OA, evoked pain responses to exogenously applied stimuli suggest that animals become sensitized to mechanical stimuli. Neurobiological techniques including electrophysiology and in vivo calcium imaging confirm that joint damage is associated with mechanical stimuli through peripheral sensitization. Read More

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October 2017
1 Read

An electrocardiographic series of flecainide toxicity.

Indian Pacing Electrophysiol J 2018 Nov 28. Epub 2018 Nov 28.

San Antonio Military Medical Center, Electrophysiology Division, Cardiology Section, 3551 Roger Brooke Drive, San Antonio, TX, 78234, USA.

Anti-arrhythmic drugs (AADs) uniquely affect the various electrolyte channels in the heart and can slow conduction, increase refractoriness, and/or decrease automaticity with the goal of preventing tachyarrhythmias. Due to these properties, these same drugs are by nature pro-arrhythmic. Vaughan-Williams classification Ic AADs belong to a class of medications that inhibit sodium channels, leading to decreased conduction velocity of myocytes and Purkinje fibers as well as to decreased automaticity of pacemaker cells. Read More

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November 2018

Atrial Fibrosis by Late Gadolinium Enhancement Magnetic Resonance Imaging and Catheter Ablation of Atrial Fibrillation: 5-Year Follow-Up Data.

J Am Heart Assoc 2018 Dec;7(23):e006313

1 Comprehensive Arrhythmia and Research Management Center Division of Cardiology Cardiovascular Medicine Division Salt Lake City UT.

Background Late gadolinium enhancement magnetic resonance imaging is an effective tool for assessment of atrial fibrosis. The degree of left atrial fibrosis is a good predictor of atrial fibrillation ( AF ) ablation success at 1 year, but the association between left atrial fibrosis and long-term ablation success has not been studied. Methods and Results Late gadolinium enhancement magnetic resonance images of sufficient quality to quantify atrial fibrosis were obtained before the first AF ablation in 308 consecutive patients. Read More

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December 2018
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Surgical left atrial appendage occlusion during cardiac surgery: A systematic review and meta-analysis.

World J Cardiol 2018 Nov;10(11):242-249

Division of Cardiovascular diseases, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, United States.

Aim: To evaluate the safety and efficacy of surgical left atrial appendage occlusion (s-LAAO) during concomitant cardiac surgery.

Methods: We performed a comprehensive literature search through May 31st 2018 for all eligible studies comparing s-LAAO vs no occlusion in patients undergoing cardiac surgery. Clinical outcomes during follow-up included: embolic events, stroke, all-cause mortality, atrial fibrillation (AF), reoperation for bleeding and postoperative complications. Read More

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November 2018
2 Reads

Two distinct profiles of fMRI and neurophysiological activity elicited by acetylcholine in visual cortex.

Proc Natl Acad Sci U S A 2018 Dec 3. Epub 2018 Dec 3.

Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, D-72076 Tübingen, Germany.

Cholinergic neuromodulation is involved in all aspects of sensory processing and is crucial for processes such as attention, learning and memory, etc. However, despite the known roles of acetylcholine (ACh), we still do not how to disentangle ACh contributions from sensory or task-evoked changes in functional magnetic resonance imaging (fMRI). Here, we investigated the effects of local injection of ACh on fMRI and neural signals in the primary visual cortex (V1) of anesthetized macaques by combining pharmaco-based MRI (phMRI) with electrophysiological recordings, using single electrodes and electrode arrays. Read More

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December 2018

Prolonged action potential duration and dynamic transmural action potential duration heterogeneity underlie vulnerability to ventricular tachycardia in patients undergoing ventricular tachycardia ablation.

Europace 2018 Nov 29. Epub 2018 Nov 29.

Department of Cardiac Electrophysiology, The Barts Heart Center, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK.

Aims: Differences of action potential duration (APD) in regions of myocardial scar and their borderzones are poorly defined in the intact human heart. Heterogeneities in APD may play an important role in the generation of ventricular tachycardia (VT) by creating regions of functional block. We aimed to investigate the transmural and planar differences of APD in patients admitted for VT ablation. Read More

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November 2018

Challenges in clinical decision-making on concomitant drug therapies in patients with atrial fibrillation taking oral anticoagulants.

Eur Heart J 2018 Nov 29. Epub 2018 Nov 29.

School of Medicine, University of Belgrade, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia.

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November 2018
2 Reads

Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia-A simulation study.

PLoS Comput Biol 2018 Nov 30;14(11):e1006594. Epub 2018 Nov 30.

Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United States of America.

Cardiac electrical alternans (CEA), manifested as T-wave alternans in ECG, is a clinical biomarker for predicting cardiac arrhythmias and sudden death. However, the mechanism underlying the spontaneous transition from CEA to arrhythmias remains incompletely elucidated. In this study, multiscale rabbit ventricular models were used to study the transition and a potential role of INa in perpetuating such a transition. Read More

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November 2018

Differential responses to spectrally degraded speech within human auditory cortex: An intracranial electrophysiology study.

Hear Res 2018 Nov 22;371:53-65. Epub 2018 Nov 22.

Department of Neurosurgery, The University of Iowa, Iowa City, IA, USA; Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, USA; Pappajohn Biomedical Institute, The University of Iowa, Iowa City, IA, USA.

Understanding cortical processing of spectrally degraded speech in normal-hearing subjects may provide insights into how sound information is processed by cochlear implant (CI) users. This study investigated electrocorticographic (ECoG) responses to noise-vocoded speech and related these responses to behavioral performance in a phonemic identification task. Subjects were neurosurgical patients undergoing chronic invasive monitoring for medically refractory epilepsy. Read More

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November 2018

Atrial Fibrillation and electrophysiology in Transgenic Mice with Cardiac-Restricted Overexpression of FKBP12.

Am J Physiol Heart Circ Physiol 2018 Nov 30. Epub 2018 Nov 30.

Biomedical Engineering, Indiana University Purdue University Indianapolis, United States.

Cardiomyocyte-restricted overexpression of FK506-binding protein 12 transgenic (αMyHC -FKBP12) mice develop spontaneous atrial fibrillation (AF). The aim of the present study is to explore the mechanisms underlying the occurrence of AF in αMyHC-FKBP12 mice. Spontaneous AF was documented by telemetry in vivo and Langendorff-perfused hearts of αMyHC-FKBP12 and littermate control mice in vitro. Read More

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November 2018

The long-term effects of gene therapy in a novel mouse model of human MFRP-associated retinopathy.

Hum Gene Ther 2018 Nov 30. Epub 2018 Nov 30.

Shiley Eye Institute, Ophthalmology, University of California, San Diego, United States ;

Patients harboring homozygous c.498_499insC mutations in MFRP demonstrate hyperopia, microphthalmia, retinitis pigmentosa, retinal pigment epithelial (RPE) atrophy, variable degrees of foveal edema and optic disc drusen. The disease phenotype is variable however, with some patients maintaining good central vision and cone function till late in the disease. Read More

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November 2018

The most optimal procedure: Radiation exposure as low as reasonably achievable, efficient, faster and safer, and use of the latest technologies.

Pacing Clin Electrophysiol 2018 Nov 29. Epub 2018 Nov 29.

Division of Arrhythmia and Electrophysiology, Department of Cardiology, University of Health Sciences, Yuksek Ihtisas Heart-Education and Research Hospital, Ankara, Turkey.

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November 2018

Cellular Electrophysiology of Iron-Overloaded Cardiomyocytes.

Front Physiol 2018 15;9:1615. Epub 2018 Nov 15.

Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Iron, the most abundant transition metal element in the human body, plays an essential role in many physiological processes. However, without a physiologically active excretory pathway, iron is subject to strict homeostatic processes acting upon its absorption, storage, mobilization, and utilization. These intricate controls are perturbed in primary and secondary hemochromatoses, leading to a deposition of excess iron in multiple vital organs including the heart. Read More

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November 2018

Brugada phenocopy associated with left ventricular aneurysm.

J Electrocardiol 2018 Nov - Dec;51(6):963-965. Epub 2018 Aug 23.

Division of Cardiology, Kingston Health Sciences Centre, Queen's University, Kingston, ON, Canada.

Brugada phenocopies (BrP) are clinical entities that are characterized by ECG patterns identical to those of Brugada syndrome, but are the result of various clinical conditions. We describe the case of a 41-year-old male who exhibited BrP due to a left ventricular aneurysm in the context of chronic coronary artery disease. Read More

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Does prematurity unmask disease?

J Electrocardiol 2018 Nov - Dec;51(6):1117-1119. Epub 2018 Oct 9.

Division of Cardiology, University of California, San Francisco, United States of America; Division of Cardiology, Department of Medicine, Zuckerberg San Francisco General Hospital, San Francisco, United States of America.

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October 2018