115,832 results match your criteria Electrophysiology


Characterizing unexpected interactions of a glutamine transporter inhibitor with members of the SLC1A transporter family.

J Biol Chem 2022 Jun 22:102178. Epub 2022 Jun 22.

School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, NSW, Australia. Electronic address:

The Solute Carrier 1A (SLC1A) family comprises a group of membrane proteins that act as dual-function amino acid transporters and chloride channels and includes the alanine serine cysteine transporters (ASCTs) as well as the excitatory amino acid transporters (EAATs). ASCT2 is regarded as a promising target for cancer therapy, as it can transport glutamine and other neutral amino acids into cells and is upregulated in a range of solid tumors. The compound L-γ-glutamyl-p-nitroanilide (GPNA) is widely used in studies probing the role of ASCT2 in cancer biology; however, the mechanism by which GPNA inhibits ASCT2 is not entirely clear. Read More

View Article and Full-Text PDF

Resuming Training in High-Level Athletes After Mild COVID-19 Infection: A Multicenter Prospective Study (ASCCOVID-19).

Sports Med Open 2022 Jun 25;8(1):83. Epub 2022 Jun 25.

Laboratory of Immunology and Immunogenetics, CHU Bordeaux, 33000, Bordeaux, France.

Background: There is a paucity of data on cardiovascular sequelae of asymptomatic/mildly symptomatic SARS-Cov-2 infections (COVID).

Objectives: The aim of this prospective study was to characterize the cardiovascular sequelae of asymptomatic/mildly symptomatic COVID-19 among high/elite-level athletes.

Methods: 950 athletes (779 professional French National Rugby League (F-NRL) players; 171 student athletes) were included. Read More

View Article and Full-Text PDF

Radiographic predictors of failure of simple manual traction of transvenous implantable cardioverter-defibrillator leads: a single-center experience.

J Interv Card Electrophysiol 2022 Jun 25. Epub 2022 Jun 25.

Arrhythmia, Electrophysiology, Pacemaker Research and Management Center, Department of Cardiology, Kocaeli University Medical Faculty, Umuttepe Yerleskesi, İzmit, 41380, Kocaeli, Turkey.

Background: Extraction of the implantable cardioverter-defibrillator (ICD) leads could be a difficult procedure due to fibrous tissue around the lead and anatomical variations. In this report, we present our experience in the radiographic predictors of failure of simple manual traction (SMT) in patients with dual-coil ICD requiring lead extraction (LE).

Methods: Between January 2017 and February 2021, 103 leads were removed in 65 consecutive patients; 65 (63. Read More

View Article and Full-Text PDF

Bicyclol Attenuates Obesity-Induced Cardiomyopathy via Inhibiting NF-κB and MAPK Signaling Pathways.

Cardiovasc Drugs Ther 2022 Jun 24. Epub 2022 Jun 24.

Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325035, Wenzhou, China.

Purpose: Schisandra is a well-known traditional Chinese medicine in East Asia. As a traditional Chinese medicine derivative with Schisandra chinensis as raw material, bicyclol is well known for its significant anti-inflammatory effect. Chronic inflammation plays a significant part in obesity-induced cardiomyopathy. Read More

View Article and Full-Text PDF

Corrigendum to "Corticomuscular Coherence Dependence on Body Side and Visual Feedback" [Neuroscience 490 (2022) 144-154].

Neuroscience 2022 Jun 21. Epub 2022 Jun 21.

Laboratory of Electrophysiology for Translational NeuroScience, Institute of Cognitive Sciences and Technologies - Consiglio Nazionale delle Ricerche, Rome, Italy. Electronic address:

View Article and Full-Text PDF

Nanocurcumin substantially alleviates noise stress-induced anxiety-like behavior: the roles of tight junctions and NMDA receptors in the hippocampus.

Behav Brain Res 2022 Jun 21:113975. Epub 2022 Jun 21.

Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, I. R. Iran; Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, I. R. Iran. Electronic address:

Environmental noise stress affects non-auditory brain regions such as the hippocampus; an area of the brain implicated in cognition and emotion. Recent experimental data indicate that dysfunction of the blood-brain barrier (BBB) and overexpression of NMDA receptors may cause anxiety. In this experiment, we evaluated the effect of nanocurcumin on anxiety-like behavior and the expression of tight junctions and NMDA receptor subunits in the hippocampus of rats exposed to traffic noise. Read More

View Article and Full-Text PDF

OLHA (N-oleoylhistamine) modulates activity of mouse brain histaminergic neurons.

Neuropharmacology 2022 Jun 21:109167. Epub 2022 Jun 21.

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.

Histaminergic (HA) neurons are located in the tuberomamillary nucleus (TMN) of the posterior hypothalamus, from where they project throughout the whole brain to control wakefulness. We examined the effects of N-oleoylhistamine (OLHA), a non-enzymatic condensation product of oleic acid (OLA) and histamine, on activity of mouse HA neurons in brain slices. OLHA bidirectionally modulated the firing of HA neurons. Read More

View Article and Full-Text PDF

Altered heart cytokine profile and action potential modulation in cardiomyocytes from Mas-deficient mice.

Biochem Biophys Res Commun 2022 Jun 13;619:90-96. Epub 2022 Jun 13.

Department of Morphology, Federal University of Minas Gerais, Minas Gerais, Brazil. Electronic address:

The renin-angiotensin system (RAS) is a key hormonal system. In recent years, the functional analysis of the novel axis of the RAS (ACE2/Ang-(1-7)/Mas receptor) revealed that its activation can become protective against several pathologies, including cardiovascular diseases. Mas knockout mice (Mas-KO) represent an important tool for new investigations. Read More

View Article and Full-Text PDF

Re-evaluating methods reporting practices to improve reproducibility: an analysis of methodological rigor for the Langendorff whole-heart technique.

Am J Physiol Heart Circ Physiol 2022 Jun 24. Epub 2022 Jun 24.

Virginia Tech Carilion School of Medicine. Roanoke, Virginia.

In recent decades, the scientific community has seen an increased interest in rigor and reproducibility. In 2017, concerns of methodological thoroughness and reporting practices were implicated as significant barriers to reproducibility within the preclinical cardiovascular literature, particularly in studies employing animal research. The Langendorff, whole-heart technique has proven to be an invaluable research tool, being modified in a myriad of ways to probe questions across the spectrum of physio- and pathophysiologic function of the heart. Read More

View Article and Full-Text PDF

All That Glitters Is Not Scar.

Circ Arrhythm Electrophysiol 2022 Jun 24:101161CIRCEP122011173. Epub 2022 Jun 24.

Division of Cardiovascular Medicine, Section of Cardiac Electrophysiology, Hospital of the University of Pennsylvania, Philadelphia, PA.

View Article and Full-Text PDF

Temperature-controlled high-power short-duration ablation with 90 W for 4 s: outcome, safety, biophysical characteristics and cranial MRI findings in patients undergoing pulmonary vein isolation.

J Interv Card Electrophysiol 2022 Jun 24. Epub 2022 Jun 24.

Department of Electrophysiology, German Heart Center Munich, Technische Universitaet Munich, Lazarettstr. 36, 80636, Munich, Germany.

Background: High-power short-duration (HPSD) radiofrequency ablation (RFA) is highly efficient and safe while reducing procedure and RF time in pulmonary vein isolation (PVI). The QDot™ catheter is a novel contact force ablation catheter that allows automated flow and power adjustments depending on the local tissue temperature to maintain a target temperature during 90 W/4 s lesions. We analysed intraprocedural data and periprocedural safety using the QDot-catheter in patients undergoing PVI for paroxysmal atrial fibrillation (PAF). Read More

View Article and Full-Text PDF

Methods and metrics for EEG/ERP assessment of emotion and cognition in young children.

Dev Psychobiol 2022 Sep;64(6):e22284

Department of Psychological and Brain Sciences, Texas A&M University, College Station, Texas, USA.

View Article and Full-Text PDF
September 2022

Mechanistic vs. empirical ablation of atria during repeat ablation for atrial arrhythmias despite effective pulmonary vein isolation.

Authors:
Ugur Canpolat

J Cardiovasc Electrophysiol 2022 Jun 24. Epub 2022 Jun 24.

Hacettepe University Faculty of Medicine, Department of Cardiology, Arrhythmia and Electrophysiology Unit, Ankara, Turkey.

In this issue of the journal, Sciacca et al. (Ref) reported their single center experience in a small non-randomized observational study about the catheter ablation approach and outcomes in 74 patients with atrial arrhythmia reccurence [atrial fibrillation (AF) (36.5%) and atrial tachycardia (AT) (63. Read More

View Article and Full-Text PDF

Anti-lung cancer effect of paclitaxel solid lipid nanoparticles delivery system with curcumin as co-loading partner in vitro and in vivo.

Drug Deliv 2022 Dec;29(1):1878-1891

Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, P. R. China.

The main aim of this study was to improve the therapeutic potential of a paclitaxel (PTX) and curcumin (CU) combination regimen using solid lipid nanoparticles (SLNs). PTX and CU were successfully co-encapsulated at a predetermined ratio in SLNs (PC-SLNs) with high encapsulation efficiency (CU: 97.6%, PTX: 95. Read More

View Article and Full-Text PDF
December 2022

Impact of cardiac resynchronization therapy optimization inside a heart failure programme: a real-world experience.

ESC Heart Fail 2022 Jun 24. Epub 2022 Jun 24.

Department of Cardiology, FHU SENEC, AP-HP, University Hospital Henri Mondor, Créteil, France.

Aims: This study sought to describe and evaluate the impact of a routine in-hospital cardiac resynchronization therapy (CRT) programme, including comprehensive heart failure (HF) evaluation and systematic echo-guided CRT optimization.

Methods And Results: CRT implanted patients were referred for optimization programme at 3 to 12 months from implantation. The program included clinical and biological status, standardized screening for potential cause of CRT non-response and systematic echo-guided atrioventricular and interventricular delays (AVd and VVd) optimization. Read More

View Article and Full-Text PDF

Evaluating the use of a mobile device for detection of atrial fibrillation in primary care.

Br J Cardiol 2021 27;28(1). Epub 2021 Jan 27.

NIHR Clinical Lecturer Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, LE5 4PW.

A trial fibrillation (AF) increases cardio-embolic stroke risk, yet AF diagnosis and subsequent prophylactic anticoagulant prescription rates are suboptimal globally. This project aimed to increase AF diagnosis and subsequent anticoagulation prescription rates in East Midlands Clinical Commissioning Groups (CCGs). This service improvement evaluation of the East Midlands AF Advance programme investigated the implementation of mobile AF detection devices (Kardia, AliveCor) into primary-care practices within East Midlands CCGs, along with audit tools and clinician upskilling workshops designed to increase AF diagnosis and anticoagulation prescription rates. Read More

View Article and Full-Text PDF
January 2021

Comm ex Lamm (Araliaceae) leaves extract inhibits IKs not IKr potassium currents: Potential implications for anti-arrhythmic therapy.

J Tradit Complement Med 2022 Jul 16;12(4):330-334. Epub 2021 Sep 16.

Laboratoire de Signalisation et Transport Ionique Membranaire, Pole Biosanté, Université de Poitiers, BP 86000, Poitiers, France.

Background And Aim: Comm ex Lamm (Araliaceae) is one of these plants sufficiently exploited in traditional African medicine for its hypotensive effect. However, the pharmacological effects of those plants on cardiac functions are not well known. The potassium currents IKs and IKr, responsible for the repolarization of cardiac cell action potential, strongly influence the human cardiac rhythm. Read More

View Article and Full-Text PDF

Impact of COVID-19 on primary percutaneous coronary intervention centres in the UK: a survey.

Br J Cardiol 2020 11;27(2):17. Epub 2020 Jun 11.

Professor of Cardiovascular Medicine School of Medicine and Dentistry, University of Central Lancashire, Preston, PR1 2HE.

During the coronavirus disease (COVID-19) pandemic, the British Cardiovascular Society/British Cardiovascular Intervention Society and the British Heart Rhythm Society recommended to postpone non-urgent elective work and that primary percutaneous coronary intervention (PCI) should remain the treatment of choice for patients with ST-segment elevation myocardial infarction (STEMI). We sought to determine the impact of COVID-19 on the primary PCI service within the United Kingdom (UK). A survey of 43 UK primary PCI centres was performed and a significant reduction in the number of cath labs open was found (pre-COVID 3. Read More

View Article and Full-Text PDF

Repetitive mild traumatic brain injury induces persistent alterations in spontaneous synaptic activity of hippocampal CA1 pyramidal neurons.

IBRO Neurosci Rep 2022 Jun 9;12:157-162. Epub 2022 Feb 9.

Uniformed Services University of the Health Sciences, Edward Hebert School of Medicine, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA.

Mild traumatic brain injury (mTBI) or concussion is the most common form of TBI which frequently results in persistent cognitive impairments and memory deficits in affected individuals [1]. Although most studies have investigated the role of hippocampal synaptic dysfunction in earlier time points following a single injury, the long-lasting effects of mTBI on hippocampal synaptic transmission following multiple brain concussions have not been well-elucidated. Using a repetitive closed head injury (3XCHI) mouse model of mTBI, we examined the alteration of spontaneous synaptic transmission onto hippocampal CA1 pyramidal neurons by recording spontaneous excitatory AMPA receptor (AMPAR)- and inhibitory GABAR-mediated postsynaptic currents (sEPSCs and sIPSCs, respectively) in adult male mice 2-weeks following the injury. Read More

View Article and Full-Text PDF

Deep Learning Analysis of Polish Electronic Health Records for Diagnosis Prediction in Patients with Cardiovascular Diseases.

J Pers Med 2022 May 25;12(6). Epub 2022 May 25.

Department of Cardiology and Structural Heart Diseases, School of Medicine in Katowice, Medical University of Silesia, 40-055 Katowice, Poland.

Electronic health records naturally contain most of the medical information in the form of doctor's notes as unstructured or semi-structured texts. Current deep learning text analysis approaches allow researchers to reveal the inner semantics of text information and even identify hidden consequences that can offer extra decision support to doctors. In the presented article, we offer a new automated analysis of Polish summary texts of patient hospitalizations. Read More

View Article and Full-Text PDF

Combining Cortical Voltage Imaging and Hippocampal Electrophysiology for Investigating Global, Multi-Timescale Activity Interactions in the Brain.

Int J Mol Sci 2022 Jun 19;23(12). Epub 2022 Jun 19.

Donders Institute for Brain Cognition and Behaviour, Radboud University, 6525AJ Nijmegen, The Netherlands.

A new generation of optogenetic tools for analyzing neural activity has been contributing to the elucidation of classical open questions in neuroscience. Specifically, voltage imaging technologies using enhanced genetically encoded voltage indicators have been increasingly used to observe the dynamics of large circuits at the mesoscale. Here, we describe how to combine cortical wide-field voltage imaging with hippocampal electrophysiology in awake, behaving mice. Read More

View Article and Full-Text PDF

Dietary Long-Chain n-3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice.

Int J Mol Sci 2022 Jun 14;23(12). Epub 2022 Jun 14.

Laboratoire NutriNeuro, UMR INRAE 1286, Bordeaux INP, Université de Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France.

Long-chain (LC) n-3 polyunsaturated fatty acids (PUFAs) have drawn attention in the field of neuropsychiatric disorders, in particular depression. However, whether dietary supplementation with LC n-3 PUFA protects from the development of mood disorders is still a matter of debate. In the present study, we studied the effect of a two-month exposure to isocaloric diets containing n-3 PUFAs in the form of relatively short-chain (SC) (6% of rapeseed oil, enriched in α-linolenic acid (ALA)) or LC (6% of tuna oil, enriched in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) PUFAs on behavior and synaptic plasticity of mice submitted or not to a chronic social defeat stress (CSDS), previously reported to alter emotional and social behavior, as well as synaptic plasticity in the nucleus accumbens (NAc). Read More

View Article and Full-Text PDF

Binge-like Prenatal Ethanol Exposure Causes Impaired Cellular Differentiation in the Embryonic Forebrain and Synaptic and Behavioral Defects in Adult Mice.

Brain Sci 2022 Jun 17;12(6). Epub 2022 Jun 17.

Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.

An embryo's in-utero exposure to ethanol due to a mother's alcohol drinking results in a range of deficits in the child that are collectively termed fetal alcohol spectrum disorders (FASDs). Prenatal ethanol exposure is one of the leading causes of preventable intellectual disability. Its neurobehavioral underpinnings warrant systematic research. Read More

View Article and Full-Text PDF

Synaptic Dysfunction by Mutations in : Influence of Triheteromeric NMDA Receptors on Gain-of-Function and Loss-of-Function Mutant Classification.

Brain Sci 2022 Jun 15;12(6). Epub 2022 Jun 15.

Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.

mutations are rare but often associated with patients having severe neurodevelopmental disorders with varying range of symptoms such as intellectual disability, developmental delay and epilepsy. Patient symptoms likely arise from mutations disturbing the role that the encoded NMDA receptor subunit, GluN2B, plays at neuronal connections in the developing nervous system. In this study, we investigated the cell-autonomous effects of putative gain- (GoF) and loss-of-function (LoF) missense mutations on excitatory synapses onto CA1 pyramidal neurons in organotypic hippocampal slices. Read More

View Article and Full-Text PDF

A Brief Introduction to Magnetoencephalography (MEG) and Its Clinical Applications.

Brain Sci 2022 Jun 15;12(6). Epub 2022 Jun 15.

Cognitive Neuroimaging Centre, Nanyang Technological University, Singapore 636921, Singapore.

Magnetoencephalography (MEG) plays a pivotal role in the diagnosis of brain disorders. In this review, we have investigated potential MEG applications for analysing brain disorders. The signal-to-noise ratio (SNR = 2. Read More

View Article and Full-Text PDF

ALARA in Pediatric Electrophysiology Laboratory.

Authors:
Harinder R Singh

Children (Basel) 2022 Jun 10;9(6). Epub 2022 Jun 10.

Baylor College of Medicine, Children's Hospital of San Antonio, San Antonio, TX 78207, USA.

The effects of radiation on patients and the providers are dose-dependent and cumulative. Pediatric patients are not only more sensitive to radiation but also may undergo more procedures and diagnostic tests throughout their lifetime. As providers, the endeavor is to cause no harm and it behooves us to either eliminate or minimize the radiation exposure to patients without affecting the efficacy and outcomes of the diagnostic or therapeutic modalities. Read More

View Article and Full-Text PDF

Incidence and Outcomes of Patients With Watchman FLX "Fluttering".

JACC Clin Electrophysiol 2022 Jun 27;8(6):822-823. Epub 2022 Apr 27.

Helsmley Electrophysiology Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Cardiology, Homolka Hospital, Prague, Czech Republic. Electronic address:

View Article and Full-Text PDF

Coagulation Response and Prothrombotic Effect of Uninterrupted Oral Anticoagulant Administration After Catheter Ablation for VT.

JACC Clin Electrophysiol 2022 Jun 27;8(6):735-748. Epub 2022 Apr 27.

Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Catheter ablation for ventricular tachycardia (VT) is associated with perioperative thromboembolic risk. However, the strategy for postprocedural management remains unknown.

Objectives: The aim of this study was to evaluate the prothrombotic response after VT ablation in various coagulation biomarkers in patients with and without the administration of oral anticoagulation (OAC). Read More

View Article and Full-Text PDF

Pulsed Field Ablation of Left Ventricular Myocardium in a Swine Infarct Model.

JACC Clin Electrophysiol 2022 Jun 28;8(6):722-731. Epub 2022 Apr 28.

Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California-San Francisco, San Francisco, California, USA. Electronic address:

Background: Pulsed field ablation (PFA) leads to cell death by irreversible electroporation. There are limited data about PFA lesion characteristics in the ventricle, particularly in the presence of myocardial scar.

Objectives: This study sought to evaluate the lesion characteristics of PFA and radiofrequency energy (RFA) in healthy and infarcted left ventricular (LV) myocardium in swine. Read More

View Article and Full-Text PDF

Rediscovering Repolarization: Timing Is Everything.

Authors:
Pier D Lambiase

JACC Clin Electrophysiol 2022 Jun;8(6):719-721

University College London Institute of Cardiovascular Science, Barts Heart Centre, London, United Kingdom. Electronic address:

View Article and Full-Text PDF