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Heart Rhythm 2020 Jun 30. Epub 2020 Jun 30.

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Pacific Rim Electrophysiology Research Institute, Bumrungrad Hospital, Bangkok, Thailand.

Background: Mutations in SCN5A are rarely found in Thai patients with Brugada syndrome (BrS). Recent evidence suggested that common genetic variation may underlie BrS in a complex inheritance model.

Objective: To find common and rare/low frequency genetic variants predisposing to BrS in Thailand. Read More

J Cardiovasc Electrophysiol 2020 Jul 3. Epub 2020 Jul 3.

Northwell Health, Division of Electrophysiology, Manhasset, New York, USA.

Background: Idiopathic ventricular arrhythmias (IVA) from the left ventricular (LV) summit may be successfully ablated from the distal great cardiac vein (dGCV). Using a 12-lead electrocardiogram (ECG) to localize IVAs that can be ablated from the dGCV is valuable for ablation planning.

Objective: To determine if a "w" wave, a notch in the q wave in lead I, and other ECG features can identify IVAs that can be successfully ablated from the dGCV. Read More

Pflugers Arch 2020 Jul 2. Epub 2020 Jul 2.

, Almere, Netherlands.

Europace 2020 Jul 2. Epub 2020 Jul 2.

Department of Electrophysiology, Heart Center-University of Leipzig, Strümpellstr. 39, 04289 Leipzig, Germany.

Eur Heart J Case Rep 2020 Jun 26;4(3):1-5. Epub 2020 Mar 26.

Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Georgstr. 11, 32545 Bad Oeynhausen, Germany.

Background: Cardiac tamponade is one of the most serious complications when performing cardiac interventions. Although most of the patients can be treated effectively using pericardiocentesis, urgent surgery can be necessary in case of continuous bleeding and patients' haemodynamic impairment.

Case Summary: With this unique clinical case report we describe an acute endovascular occlusion of a cardiac perforation utilizing the inflated 28 mm cryoballon at the transseptal puncture site close to the superior part of the coronary sinus ostium in a patient with persistent left superior vena cava (PLSVC) and severe post-procedural tamponade. Read More

Diabetes Res Clin Pract 2020 Jun 29:108289. Epub 2020 Jun 29.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai 200233, China. Electronic address:

Aims: Continuous glucose monitoring (CGM)-derived time-in-range (TIR) of 3.9-10 mmol/L is associated with diabetic retinopathy in type 2 diabetes (T2DM), but its relationship to peripheral nerve function has not been previously investigated. To explore the association between the TIR and nerve conduction study parameters in patients with T2DM, we performed a cross-sectional analysis. Read More

Age Ageing 2020 Jul 2. Epub 2020 Jul 2.

Cardiology Department, Maastricht University Medical Centre, Maastricht 6229 HX, The Netherlands.

Background: Haloperidol at high dosage is associated with QTc prolongation and polymorphic ventricular arrhythmia but the effects of low-dose haloperidol remain unknown.

Objective: To evaluate the effects of low-dose haloperidol on QTc-duration in frail hospitalized elderly patients with delirium.

Methods: A prospective observational study including hospitalized patients aged ≥70 years with Groningen Frailty Index-score > 3. Read More

J Cell Mol Med 2020 Jul 1. Epub 2020 Jul 1.

Drug Discovery Research Center, Southwest Medical University, Luzhou, China.

Glycation of extracellular matrix proteins has been demonstrated to contribute to the pathogenesis of vascular complications. However, no previous report has shown the role of glycated fibronectin (FN) in vascular endothelial growth factor (VEGF)-induced angiogenesis. Thus, this study aimed to investigate the effects of glycated FN on VEGF signalling and to clarify the molecular mechanisms involved. Read More

Int J Cardiovasc Imaging 2020 Jul 1. Epub 2020 Jul 1.

Department of Cardiovascular Imaging, Fundación Cardioinfantil, Calle 163a #13B-60, 110131, Bogotá, Colombia.

Chagas' disease (CD), caused by the parasite Trypanosoma cruzi, is the leading cause of cardiac disability from infectious diseases in Central and South America. The disease progresses through an extended, asymptomatic form characterized by latency without clinical manifestations into a symptomatic form with cardiac and gastro-intestinal manifestations. In the terminal phase, chronic Chagas' myocarditis results in extensive myocardial fibrosis, chamber enlargement with aneurysms and ventricular tachycardia (VT). Read More

Front Pediatr 2020 16;8:313. Epub 2020 Jun 16.

University Children's Hospital Regensburg (KUNO), University of Regensburg, Regensburg, Germany.

We report on a 12-month-old girl with an ectopic atrial tachycardia successfully treated with the combination of a beta blocking agent and Ivabradine that acts on cardiac pacemaker cells by selectively inhibiting the I channel. Standard therapy had failed to control the tachycardia before. No side effects attributable to Ivabradine were noticed. Read More

Front Cell Neurosci 2020 16;14:164. Epub 2020 Jun 16.

Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden.

The maintenance of the excitability of neurons and circuits is a fundamental process for healthy brain functions. One of the main homeostatic mechanisms responsible for such regulation is synaptic scaling. While this type of plasticity is well-characterized through a robust body of literature, there are no systematic evaluations of the methodological and reporting features from these studies. Read More

Acta Pharmacol Sin 2020 Jul 1. Epub 2020 Jul 1.

Cardiac Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China.

Eleutheroside B (EB) is the main active constituent derived from the Chinese herb Acanthopanax senticosus (AS) that has been reported to possess cardioprotective effects. In this study we investigated the effects of EB on cardiac electrophysiology and its suppression on atrial fibrillation (AF). Whole-cell recording was conducted in isolated rabbit atrial myocytes. Read More

J Biol Chem 2020 Jul 1. Epub 2020 Jul 1.

Medicinal Chemistry and Molecular Pharmacology, Purdue University, United States.

Nav1.6 is the primary voltage-gated sodium channel isoform expressed in mature axon initial segments and nodes, making it critical for initiation and propagation of neuronal impulses. Thus, Nav1. Read More

J Neurosci 2020 Jul 2. Epub 2020 Jul 2.

Institute of Physiology CAS, Videnska 1083, 142 20 Prague 4, Czech Republic

N-methyl-D-aspartate receptor (NMDAR) hypofunction has been implicated in several neurodevelopmental disorders. NMDAR function can be augmented by positive allosteric modulators, including endogenous compounds, such as cholesterol and neurosteroid pregnenolone sulfate (PES). Here we report that PES accesses the receptor via the membrane and its binding site is different from that of cholesterol. Read More

Cardiology 2020 Jul 1:1-12. Epub 2020 Jul 1.

Department of Cardiology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey.

Supraventricular tachycardias (SVTs) are common arrhythmic conditions in clinical practice. Increased knowledge and experience on SVTs and some unclear situations in clinical practice led the European Society of Cardiology (ESC) team to write a new guideline. In this review, we touch upon the important points in the new ESC 2019 SVT guidelines and present changing approaches and suggestions. Read More

Neurosurg Focus 2020 Jul;49(1):E6

1Department of Neurologic Surgery.

The development of closed-loop deep brain stimulation (DBS) systems represents a significant opportunity for innovation in the clinical application of neurostimulation therapies. Despite the highly dynamic nature of neurological diseases, open-loop DBS applications are incapable of modifying parameters in real time to react to fluctuations in disease states. Thus, current practice for the designation of stimulation parameters, such as duration, amplitude, and pulse frequency, is an algorithmic process. Read More

Neurosurg Focus 2020 Jul;49(1):E5

2Neurology.

Objective: Intracranial human brain recordings typically utilize recording systems that do not distinguish individual neuron action potentials. In such cases, individual neurons are not identified by location within functional circuits. In this paper, verified localization of singly recorded hippocampal neurons within the CA3 and CA1 cell fields is demonstrated. Read More

Neurosurg Focus 2020 Jul;49(1):E4

Departments of1Neurological Surgery and.

Objective: Motor brain-computer interface (BCI) represents a new frontier in neurological surgery that could provide significant benefits for patients living with motor deficits. Both the primary motor cortex and posterior parietal cortex have successfully been used as a neural source for human motor BCI, leading to interest in exploring other brain areas involved in motor control. The amygdala is one area that has been shown to have functional connectivity to the motor system; however, its role in movement execution is not well studied. Read More

Cell Rep 2020 Jun;31(13):107833

Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address:

Glucagon-like peptide-1 (GLP-1) from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine cells are under development, with the aim to mimic endocrine effects of gastric bypass surgery, but they are difficult to develop without human L-cell models. Human ileal organoids, engineered by CRISPR-Cas9, express the fluorescent protein Venus in the proglucagon locus, enabling maintenance of live, identifiable human L-cells in culture. Read More

Elife 2020 Jul 1;9. Epub 2020 Jul 1.

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.

We identify a set of common phenotypic modifiers that interact with five independent autism gene orthologs (, , , , ) causing a common failure of presynaptic homeostatic plasticity (PHP) in . Heterozygous null mutations in each autism gene are demonstrated to have normal baseline neurotransmission and PHP. However, PHP is sensitized and rendered prone to failure. Read More

Future Cardiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Cardiology, cNEP, Cardiac Neuro- & Electrophysiology Research Group, University Heart & Vascular Center Hamburg, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

Ultra-high-density mapping (HDM) is increasingly used for guidance of catheter ablation in cardiac arrhythmias. While initial results are promising, a systematic evaluation of long-term outcome has not been performed so far. A systematic review and meta-analysis was conducted on studies investigating long-term outcome after Rhythmia HDM-guided atrial fibrillation (AF) or atrial tachycardia catheter ablation. Read More

J Cardiovasc Electrophysiol 2020 Jul 1. Epub 2020 Jul 1.

Heart and Vascular Institute, Division of Cardiac Electrophysiology, St Elizabeth Healthcare, Edgewood, KY.

Cardiac resynchronization therapy (CRT) is associated with improvement in quality of life, hospitalization rates and mortality in patients with left ventricular dysfunction and evidence of RV-LV desynchrony. Implant failure rates and patient outcomes have improved with the advent of quadripolar leads, yet alternatives to traditional coronary sinus (CS) LV lead placement is sought for in a subset of advanced heart failure patients with difficult CS anatomy, phrenic nerve stimulation or in non-responders. Endocardial Left ventricular pacing (EnLVP) in chronically anticoagulated patients has been reported as an alternative using different approaches, techniques and tools with acceptable short and long term adverse events. Read More

J Cardiovasc Electrophysiol 2020 Jun 30. Epub 2020 Jun 30.

Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

We present a case of a 67-year-old female with a previous history of a pulmonary vein isolation for paroxysmal atrial fibrillation who presented with supraventricular bigeminy with a constant coupling interval. The supraventricular bigeminy originated from the anterior mitral annulus with initial mapping suggestive of a focal mechanism. However detailed mapping using an ultra-high resolution mapping system (with manual shifting of the annotation window) revealed very low amplitude potentials connecting the previous sinus beat with continuous activation along the mitral annulus. Read More

Indian J Pediatr 2020 Jul 1. Epub 2020 Jul 1.

Pediatric Electrophysiology and Inherited Cardiac Conditions, Department of Pediatrics, Royal Brompton Hospital & Harefield Hospital, London, UK.

J Neurol 2020 Jun 30. Epub 2020 Jun 30.

Professor Emeritus of Neurology, Service of Neurology, University Hospital "Marqués de Valdecilla (IDIVAL)", "Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)", University of Cantabria, Santander, Spain.

The aim of this review was to analyse the pathophysiology of axonal degeneration in Guillain-Barré syndrome (GBS) with emphasis on early stages (≤ 10 days after onset). An overview of experimental autoimmune neuritis (EAN) models is provided. Originally GBS and acute inflammatory demyelinating polyneuropathy were equated, presence of axonal degeneration being attributed to a "bystander" effect. Read More

Acta Myol 2020 Mar 1;39(1):32-35. Epub 2020 Mar 1.

Department of Cardiac Electrophysiology and Pacing, Istituto Clinico Sant'Ambrogio, Milan, Italy.

A significant number of sudden death (SD) is observed in myotonic dystrophy (DM1) despite pacemaker implantation and some consider the ICD to be the preferential device in patients with conduction disease. According to the latest guidelines, prophylactic ICD implantation in patients with neuromuscular disorder should follow the same recommendations of non-ischemic dilated cardiomyopathy, being reasonable when pacing is needed. We here report a case of DM1 patient who underwent ICD implantation even in the absence of conduction disturbances on ECG and ventricular dysfunction/fibrosis at cardiac magnetic resonance. Read More

Mol Psychiatry 2020 Jul 1. Epub 2020 Jul 1.

The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Many neurodevelopmental disorders are characterized by impaired functional synaptic plasticity and abnormal dendritic spine morphology, but little is known about how these are related. Previous work in the Fmr1 mouse model of fragile X (FX) suggests that increased constitutive dendritic protein synthesis yields exaggerated mGluR5-dependent long-term synaptic depression (LTD) in area CA1 of the hippocampus, but an effect on spine structural plasticity remains to be determined. In the current study, we used simultaneous electrophysiology and time-lapse two photon imaging to examine how spines change their structure during LTD induced by activation of mGluRs or NMDA receptors (NMDARs), and how this plasticity is altered in Fmr1 mice. Read More

Mol Pharmacol 2020 Jun 29. Epub 2020 Jun 29.

University of Buffalo, SUNY

Ketamine, a dissociative anesthetic, is experiencing a clinical resurgence as fast-acting antidepressant. In the central nervous system, ketamine acts primarily by blocking NMDA receptor currents. Although it is generally safe in clinical setting, it can be addictive and several of its derivatives are investigated as preferable alternatives. Read More

Br J Ophthalmol 2020 Jun 30. Epub 2020 Jun 30.

Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.

Purpose: To examine the added predictive value of microperimetric sensitivity and low luminance deficit (LLD; difference between photopic and low luminance visual acuity (VA)) to information from colour fundus photography (CFP) for progression to late age-related macular degeneration (AMD) in individuals with bilateral large drusen.

Methods: 140 participants with bilateral large drusen underwent baseline microperimetry testing, VA measurements and CFP. They were then reviewed at 6-monthly intervals to 36 months, to determine late AMD progression. Read More

J Neurosci 2020 Jun 30. Epub 2020 Jun 30.

Department of Anatomy, Howard University College of Medicine, Washington, DC 20059

Delineation of functional synaptic connections is fundamental to understanding sensory processing. Olfactory signals are synaptically processed initially in the olfactory bulb (OB) where neural circuits are formed among inhibitory interneurons and the output neurons mitral (MCs) and tufted cells (TCs). TCs function in parallel with but differently from MCs and are further classified into multiple subpopulations based on their anatomical and functional heterogeneities. Read More

Biopolymers 2020 Jun 30:e23383. Epub 2020 Jun 30.

Polymer Engineering Laboratory, School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India.

Amyloids are a group of proteins that are capable of forming aggregated amyloid fibrils, which is responsible for many neurodegenerative diseases including Alzheimer's disease (AD). In our previous study, synthesis and characterization of star-shaped poly(D,L-lactide)-b-gelatin (ss-pLG) have been reported. In the present work, we have extended our work to study ss-pLG against protein aggregation. Read More

Chin Med J (Engl) 2020 Jun 26. Epub 2020 Jun 26.

Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Background: The association between free triiodothyronine (FT3) and long-term prognosis in dilated cardiomyopathy (DCM) patients has not been evaluated. The purpose of this study was to determine whether the level of FT3 could provide prognostic value in patients with DCM.

Methods: Data of consecutive patients diagnosed with DCM were collected from October 2009 to December 2014. Read More

Heart Rhythm 2020 Jun 27. Epub 2020 Jun 27.

King's College London, Westminster Bridge Road, SE1 7EH, London, UK.

Background: His bundle pacing (HBP) and left bundle pacing (LBP) are emerging as novel delivery methods for cardiac resynchronisation therapy (CRT) in heart failure patients with left bundle branch block (LBBB). HBP and LBP have never been compared to biventricular endocardial (BiV-endo) pacing. Furthermore, there are indications of negative effects of LBP on right ventricular (RV) activation times (ATs), but these effects have not been quantified. Read More

Heart Rhythm 2020 Jun 27. Epub 2020 Jun 27.

Helmsley Electrophysiology Center, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

Background: Because device-related thrombus (DRT) portends a poor prognosis after left atrial appendage closure with the Watchman device, surveillance transesophageal echocardiograms (TEEs) are recommended at 45 days and 1 year. However, oral anticoagulants are just stopped at 45 days, rendering this early TEE unlikely to detect DRT. Indeed, DRT is most likely to occur after instituting aspirin monotherapy. Read More

J Physiol 2020 Jun 30. Epub 2020 Jun 30.

Faculty of Medicine, Department of Systems Neuroscience, Ruhr University Bochum, Bochum, Germany.

Key Points: Thalamic activity is regulated by corticothalamic feedback from layers 5B and 6. To selectively study the importance of the layer 6 corticothalamic (L6 CT) projection a transgenic mouse line was used in which layer 6 cells projecting to posterior medial thalamus (POm) were targeted for expression of channelrhodopsin-2. Repetitive optogenetic stimulation of this sub-type of L6 cells caused a rapid adaptation in POm spiking output, but had little effect on the spiking activity in the other cortical layers. Read More

J Cardiovasc Pharmacol Ther 2020 Jun 30:1074248420935263. Epub 2020 Jun 30.

Division of Cardiology, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli," Monaldi Hospital, Naples, Italy.

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is frequently present in patients with mitral regurgitation (MR). Currently, there is a lack of real-world evidence specifically addressing the clinical performance of direct oral anticoagulants (DOACs) in patients with AF and concomitant MR. Therefore, the aim of the present study was to assess the efficacy and safety profile of DOACs therapy in patients with AF and MR. Read More

J Cardiovasc Electrophysiol 2020 Jun 30. Epub 2020 Jun 30.

Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, TX, USA.

A 72-year-old woman with a history of paroxysmal atrial fibrillation (AF) and sinus node dysfunction is seen in clinic for routine follow-up. She had undergone radiofrequency ablation for AF and a dual chamber pacemaker implant (Medtronic Advisa DR MRI with 5076 active fixation leads; Medtronic, Minneapolis, MN, United States) five years prior. This article is protected by copyright. Read More

Mol Cell Biochem 2020 Jun 29. Epub 2020 Jun 29.

The Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 211166, China.

Endothelial-to-mesenchymal transition (EndMT) has been reported as a key factor in myocardial fibrosis. Acetylcholine (ACh), a neurotransmitter of the vagus nerve, has been confirmed to exert cardio-protective properties with unclear mechanisms. In this study, the specific markers of cell injury, EndMT, inflammation, and autophagy were measured. Read More

J Interv Card Electrophysiol 2020 Jun 30. Epub 2020 Jun 30.

Division of Cardiac Electrophysiology, Department of Cardiology, Northwell Health- Lenox Hill Heart and Lung, 100 East 77th Street, 2 Lachman, New York, NY, 10075, USA.

Background: Effective pulmonary vein isolation (PVI) with cryoablation depends on adequate occlusion of pulmonary veins (PV) by the cryoballoon and is therefore likely to be affected by PV and left atrial (LA) anatomical characteristics and variants. Thus, the objective of this study was to investigate the effect of LA and PV anatomy, evaluated by computed tomography (CT), on acute and long-term outcomes of cryoablation for atrial fibrillation (AF).

Methods: Fifty-eight patients (64. Read More

J Chem Ecol 2020 Jun 29. Epub 2020 Jun 29.

New Zealand Forest Research (Scion), 10 Kyle Street, Riccarton, Christchurch, New Zealand.

Portable electroantennograms (pEAG) can further our understanding of odor plume dynamics and complement laboratory-based electroantennogram tools. pEAG's can help to address important questions such as the influence of plume structure on insect behavior, the active space of semiochemical-baited traps, and the impact of biotic and abiotic factors on this active space. Challenges associated with pEAGs include their miniaturization and sensitivity, confounding environmental odors, and processing of data. Read More

J Neurosci 2020 Jun 29. Epub 2020 Jun 29.

Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Dr. NW, Calgary, AB T2N 4N1, Canada

The orbitofrontal cortex (OFC) plays a critical role in evaluating outcomes in a changing environment. Administering opioids to the OFC can alter the hedonic reaction to food rewards and increase their consumption in a subregion specific manner. However, it is unknown how mu-opioid signalling influences synaptic transmission in the OFC. Read More

Am J Cardiol 2020 May 23. Epub 2020 May 23.

Lenon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York city, New York. Electronic address:

Occult atrial fibrillation (AF) can be the underlying cause for cryptogenic stroke (CS). Implantable loop recorders (ILRs) have become an important tool for long-term arrhythmia monitoring in CS patients. Office-based ILR implantation by nonelectrophysiologist physicians is increasingly common. Read More

Am Heart J 2020 Apr 20;226:161-173. Epub 2020 Apr 20.

Adult and Child Consortium for Outcomes Research and Delivery Science, Aurora, CO; VA Eastern Colorado Geriatric Research Education and Clinical Center, Denver, CO; Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO.

Shared decision making (SDM) facilitates delivery of medical therapies that are in alignment with patients' goals and values. Medicare national coverage decision for several interventions now includes SDM mandates, but few have been evaluated in nationwide studies. Based upon a detailed needs assessment with diverse stakeholders, we developed pamphlet and video patient decision aids (PtDAs) for implantable cardioverter/defibrillator (ICD) implantation, ICD replacement, and cardiac resynchronization therapy with defibrillation to help patients contemplate, forecast, and deliberate their options. Read More

Heart Rhythm 2020 Jun 26. Epub 2020 Jun 26.

Section of Cardiac Electrophysiology, Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Heart Rhythm 2020 Jun 26. Epub 2020 Jun 26.

Department of Arrhythmology and Cardiac Electrophysiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background: Interest has grown in recent years for bipolar radiofrequency ablation (B-RFA). However, indications and outcome in patients with ventricular tachycardia (VT) are still to be defined.

Objective: To describe patient selection, safety and effectiveness of B-RFA, in a pilot cohort study of patients with nonischemic dilated cardiomyopathy (NIDCM) and drug-refractory VT. Read More

Neuroscience 2020 Jun 26. Epub 2020 Jun 26.

Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, 75390-9077, United States; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX, 75390-9077, United States. Electronic address:

Histaminergic neurons of the tuberomammillary nucleus (TMN) are important regulators of behavioral and homeostatic processes. Previous work suggested that histaminergic neurons exhibit a characteristic electrophysiological signature, allowing for their identification in brain slice preparations. However, these previous investigations focused on neurons in the ventral subregion of the TMN of rats. Read More

Biochim Biophys Acta Mol Cell Res 2020 Jun 26:118786. Epub 2020 Jun 26.

Department of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX, USA; Center for Addiction Research, The University of Texas Medical Branch, Galveston, TX, USA. Electronic address:

Background: Protein interactions between voltage-gated sodium (Nav) channels and accessory proteins play an essential role in neuronal firing and plasticity. However, a surprisingly limited number of kinases have been identified as regulators of these molecular complexes. We hypothesized that numerous as-of-yet unidentified kinases indirectly regulate the Nav channel via modulation of the intracellular fibroblast growth factor 14 (FGF14), an accessory protein with numerous unexplored phosphomotifs and required for channel function in neurons. Read More

Exp Neurol 2020 Jun 27;332:113391. Epub 2020 Jun 27.

Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

Volume-regulated anion channels (VRACs) are critically involved in regulating cell volume, and leucine-rich repeat-containing protein 8A (LRRC8A, SWELL1) is an obligatory subunit of VRACs. Cell swelling occurs early after brain ischemia, but it is unclear whether neuronal LRRC8a contributes to ischemia-induced glutamate release and brain injury. We found that Lrrc8a conditional knockout (Lrrc8a-cKO) mice produced by crossing Nestin with Lrrc8a mice died 7-8 weeks of age, indicating an essential role of neuronal LRRC8A for survival. Read More

JAMA Intern Med 2020 Jun 29. Epub 2020 Jun 29.

Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco.

J Innov Card Rhythm Manag 2020 Jun 15;11(6):4126-4127. Epub 2020 Jun 15.

Cardiovascular Division, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN, USA.