103,567 results match your criteria Electrophysiology


Visual outcome of carotid endarterectomy in patients with carotid artery stenosis.

Ann Vasc Surg 2019 Feb 12. Epub 2019 Feb 12.

Department of Vascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. Electronic address:

Purpose: Carotid endarterectomy (CEA) is deemed to restore the blood flow of the carotid and ophthalmic arteries in patients with carotid artery stenosis. However, specific changes in visual function before and after CEA are not well understood; hence, this observational study aimed to investigate the functional and structural changes in vision after CEA in those patients.

Methods: Patients with severe carotid artery stenosis (>70% with standard carotid duplex scanning or arteriography) scheduled to undergo CEA were consecutively recruited for the study between September 2015 and July 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2018.12.069DOI Listing
February 2019

Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?

Neuropharmacology 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, 70211, Finland; Laboratory of Neurobiology, Kazan Federal University, Kazan, 420008, Russia. Electronic address:

Background: Recent discovery of mechanosensitive Piezo receptors in trigeminal ganglia suggested the novel molecular candidate for generation of migraine pain. However, the contribution of Piezo channels in migraine pathology was not tested yet. Therefore, in this study, we explored a potential involvement of Piezo channels in peripheral trigeminal nociception implicated in generation of migraine pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2019.02.015DOI Listing
February 2019

Alkylphenol inverse agonists of HCN1 gating: H-bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency.

Biochem Pharmacol 2019 Feb 12. Epub 2019 Feb 12.

Weill Cornell Medicine, New York, NY, United States.

Background And Purpose: In models of neuropathic pain, inhibition of HCN1 is anti-hyperalgesic. 2,6-di-iso-propyl phenol (propofol) and its non-anesthetic congener, 2,6-di-tert-butyl phenol, inhibit HCN1 channels by stabilizing closed state(s).

Experimental: approach Using in vitro electrophysiology and kinetic modeling, we systematically explore the contribution of ligand architecture to alkylphenol-channel coupling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2019.02.013DOI Listing
February 2019

Effects of Dapagliflozin vs. Vildagliptin on Cardiometabolic Parameters in Diabetic Patients with Coronary Artery Disease: A Randomised Study.

Br J Clin Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Aims: SGLT2 inhibitors have been shown to reduce cardiovascular (CV) events and heart failure (HF) in type 2 diabetic (T2D) patients with high CV risk. DPP-4 inhibitors showed neutral effects and may increase risk of HF. We aimed to compare cardiometabolic effects of dapagliflozin and vildagliptin in T2D patients with coronary artery disease (CAD). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/bcp.13903
Publisher Site
http://dx.doi.org/10.1111/bcp.13903DOI Listing
February 2019
1 Read

[Premature ventricular contractions and tachycardia in a structurally normal heart : Idiopathic PVC and VT].

Herzschrittmacherther Elektrophysiol 2019 Feb 14. Epub 2019 Feb 14.

Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität München (LMU München), München, Deutschland.

Premature ventricular contractions (PVC) are a common, often incidental and mostly benign finding. Treatment is indicated in frequent and symptomatic PVC or in cases of worsening of left ventricular function. Idiopathic ventricular tachycardia (VT) is mostly found in patients with a structurally healthy heart. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00399-019-0607-1DOI Listing
February 2019

Pooled Analysis of Risk Stratification of Spontaneous Type 1 Brugada ECG: Focus on the Influence of Gender and EPS.

Front Physiol 2018 31;9:1951. Epub 2019 Jan 31.

Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China.

Risk stratification of patients with Brugada syndrome (BrS) is vital for accurate prognosis and therapeutic decisions. Spontaneous Type 1 ST segment elevation is generally considered to be an independent risk factor for arrhythmic events. Other risk factors include gender, syncope, sudden cardiac arrest (SCA), and positive electrophysiological study (EPS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2018.01951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365464PMC
January 2019

The Year in Electrophysiology: Selected Highlights From 2018.

J Cardiothorac Vasc Anesth 2019 Jan 22. Epub 2019 Jan 22.

Department of Anesthesiology, The Ohio State University Medical Center, Columbus, OH.

This article is the first in an annual series for the Journal of Cardiothoracic and Vascular Anesthesia. The authors thank the editor-in-chief, Dr. Kaplan, the associate editor-in-chief, Dr. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.jvca.2019.01.049DOI Listing
January 2019

Lipid Headgroup Charge and Acyl Chain Composition Modulate Closure of Bacterial β-Barrel Channels.

Int J Mol Sci 2019 Feb 5;20(3). Epub 2019 Feb 5.

Section on Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

The outer membrane of Gram-negative bacteria contains β-barrel proteins that form high-conducting ion channels providing a path for hydrophilic molecules, including antibiotics. Traditionally, these proteins have been considered to exist only in an open state so that regulation of outer membrane permeability was accomplished via protein expression. However, electrophysiological recordings show that β-barrel channels respond to transmembrane voltages by characteristically switching from a high-conducting, open state, to a so-called 'closed' state, with reduced permeability and possibly exclusion of large metabolites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20030674DOI Listing
February 2019

Differentiation of Fasciculoventricular Fibers from Anteroseptal Accessory Pathways Using the Surface Electrocardiogram.

Heart Rhythm 2019 Feb 11. Epub 2019 Feb 11.

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts. Electronic address:

Background: Fasciculoventricular fibers (FVFs) are responsible for 1-5% of cases of asymptomatic pre-excitation on surface electrocardiogram (ECG). Unlike ventricular pre-excitation seen in Wolff-Parkinson-White (WPW) syndrome, FVFs are not associated with sudden cardiac death from pre-excited atrial fibrillation.

Objective: To identify surface ECG variables that differentiate FVFs from true WPW syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2019.02.011DOI Listing
February 2019

Effect of lentiviral vector-mediated overexpression of hypoxia-inducible factor 1 alpha delivered by pluronic F-127 hydrogel on brachial plexus avulsion in rats.

Neural Regen Res 2019 Jun;14(6):1069-1078

Institute of Stem Cells and Regenerative Medicine, Department of Physiology, Guangdong Medical University, Dongguan, Guangdong Province, China.

Brachial plexus avulsion often results in massive motor neuron death and severe functional deficits of target muscles. However, no satisfactory treatment is currently available. Hypoxia-inducible factor 1α is a critical molecule targeting several genes associated with ischemia-hypoxia damage and angiogenesis. Read More

View Article

Download full-text PDF

Source
http://www.nrronline.org/text.asp?2019/14/6/1069/250629
Publisher Site
http://dx.doi.org/10.4103/1673-5374.250629DOI Listing
June 2019
1 Read

Conflict Adaptation in 5-Year-Old Preschool Children: Evidence From Emotional Contexts.

Front Hum Neurosci 2019 29;13:14. Epub 2019 Jan 29.

CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

This research investigated the individual behavioral and electrophysiological differences during emotional conflict adaptation processes in preschool children. Thirty children (16 girls, mean age 5.44 ± 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnhum.2019.00014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361790PMC
January 2019

Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming.

Front Mol Neurosci 2018 19;11:323. Epub 2018 Sep 19.

INSERM U1016, Institut Cochin, Paris, France.

Despite progress, our understanding of psychiatric and neurological illnesses remains poor, at least in part due to the inability to access neurons directly from patients. Currently, there are models available but significant work remains, including the search for a less invasive, inexpensive and rapid method to obtain neuronal-like cells with the capacity to deliver reproducible results. Here, we present a new protocol to transdifferentiate human circulating monocytes into neuronal-like cells in 20 days and without the need for viral insertion or reprograming. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2018.00323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156467PMC
September 2018

MRI for patients with cardiac implantable electronic devices: simplifying complexity with a 'one-stop' service model.

BMJ Qual Saf 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiac Imaging, Barts Heart Centre, Barts Health NHS Trust, London, UK.

Background: Patients with cardiac pacemakers and defibrillators are disadvantaged because of poor access to MRI scans, leading to late and misdiagnosis particularly for cancer and neurological disease. New technology allied to tested protocols now allows safe MRI scanning of such patients; however, logistical barriers persist.

Aim: To deliver a streamlined sustainable service that provides timely MRI scans to patients with cardiac implantable electronic devices (CIEDs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjqs-2018-009079DOI Listing
February 2019

Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.

Proc Natl Acad Sci U S A 2019 Feb 13. Epub 2019 Feb 13.

Geriatric Research Educational and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15240;

Ubiquitin C-terminal hydrolase L1 (UCHL1) is a unique brain-specific deubiquitinating enzyme. Mutations in and aberrant function of UCHL1 have been linked to many neurological disorders. UCHL1 activity protects neurons from hypoxic injury, and binding of stroke-induced reactive lipid species to the cysteine 152 (C152) of UCHL1 unfolds the protein and disrupts its function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1821282116DOI Listing
February 2019

Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials.

Eur Heart J Acute Cardiovasc Care 2019 Feb 14:2048872619830609. Epub 2019 Feb 14.

3 Department of Cardiology, Radboud University Medical Center, The Netherlands.

Background:: Conflicting evidence is available on the efficacy and safety of early intravenous beta-blockers before primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. We performed a patient-pooled meta-analysis of trials comparing early intravenous beta-blockers with placebo or routine care in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention.

Aim:: The aim of this study was to evaluate the clinical and safety outcomes of intravenous beta-blockers in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2048872619830609DOI Listing
February 2019

Clinical Management of High and Very High Risk Patients with Hyperlipidaemia in Central and Eastern Europe: An Observational Study.

Adv Ther 2019 Feb 13. Epub 2019 Feb 13.

Amgen Bulgaria EOOD, Sofia, Bulgaria.

Introduction: A retrospective/prospective observational study was conducted to explore the current management of hyperlipidaemia in high-risk (HR) and very high risk (VHR) patients in central/eastern Europe and Israel.

Methods: The study enrolled adult patients who were receiving lipid-lowering therapy and attending a specialist (cardiologist/diabetologist/lipidologist) or internist for a routine visit at 57 sites (including academic/specialist/internal medicine centres) across Bulgaria, Croatia, Czech Republic, Israel, Poland, Romania and Slovakia. Data were collected from medical records, for the 12 months before enrolment, with/without ≤ 6 months' additional prospective follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12325-019-0879-1DOI Listing
February 2019

Regional differences in patient characteristics and outcomes during uninterrupted anticoagulation with dabigatran versus warfarin in catheter ablation of atrial fibrillation: the RE-CIRCUIT study.

J Interv Card Electrophysiol 2019 Feb 13. Epub 2019 Feb 13.

Cardiac Electrophysiology and Arrhythmia Service, University of California, San Francisco, CA, USA.

Purpose: To describe regional differences in patient characteristics, ablation procedures, and bleeding events in the RE-CIRCUIT study. RE-CIRCUIT was a prospective, multicenter study that captured data from different regions, providing an opportunity to understand the practices followed in various regions. The incidence of major bleeding events (MBEs) was significantly lower with uninterrupted dabigatran versus uninterrupted warfarin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10840-019-00518-xDOI Listing
February 2019
1 Read

There is no tailored approach for antibiotic prophylaxis after device implantation.

Authors:
Majid Haghjoo

Pacing Clin Electrophysiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiac Electrophysiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pace.13628DOI Listing
February 2019

Mechano-electric abnormality of "myocardial-valvular syndrome": More than a leaflet prolapse.

Authors:
Ugur Canpolat

Pacing Clin Electrophysiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiology, Arrhythmia and Electrophysiology Unit, Hacettepe University, Ankara, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pace.13631DOI Listing
February 2019

Tailored antibiotic prophylaxis in patients undergoing CIED implantation: One size does not fit all principle.

Authors:
Ugur Canpolat

Pacing Clin Electrophysiol 2019 Feb 13. Epub 2019 Feb 13.

Hacettepe University, Department of Cardiology, Arrhythmia and Electrophysiology Unit, Ankara, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pace.13624DOI Listing
February 2019

Declaration of the known facts in myopathy: Pacing in order to capture future occurrence of PVC-induced myopathy?

Authors:
Ugur Canpolat

Pacing Clin Electrophysiol 2019 Feb 13. Epub 2019 Feb 13.

Hacettepe University, Department of Cardiology, Arrhythmia and Electrophysiology Unit, Ankara, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pace.13623DOI Listing
February 2019

Prelimbic Cortical Neurons Track Preferred Reward Value and Reflect Impulsive Choice During Delay Discounting Behavior.

J Neurosci 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychology and Neuroscience, The University of North Carolina, Chapel Hill, NC 27599

In delay discounting, individuals discount the value of a reward based on the delay to its receipt. The prelimbic cortex (PrL) is heavily interconnected with several brain regions implicated in delay discounting, but the specific contributions of the PrL to delay discounting are unknown. Here, we used multineuron electrophysiological recording methods in Long Evans male (n=10) and female (n=9) rats to characterize the firing dynamics of PrL neurons during discrete cue and lever press events in a delay discounting task. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2532-18.2019DOI Listing
February 2019

Epinephrine Administered for Anaphylaxis Unmasking a Type 1 Brugada Pattern on Electrocardiogram.

J Emerg Med 2019 Feb 9. Epub 2019 Feb 9.

Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan.

Background: Brugada pattern on electrocardiography (ECG) can manifest as type 1 (coved pattern) and type 2 (saddleback pattern). Brugada syndrome represents an ECG with Brugada pattern in a patient with symptoms or clinical factors, including syncope, cardiac arrest, ventricular dysrhythmias, and family history. Brugada syndrome is caused by a genetic channelopathy, but the Brugada pattern may be drug-induced. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jemermed.2018.12.045DOI Listing
February 2019

The role of personalized atrial modeling in understanding atrial fibrillation mechanisms and improving treatment.

Int J Cardiol 2019 Jan 31. Epub 2019 Jan 31.

Department of Biomedical Engineering and the Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

Atrial fibrillation is the most common arrhythmia in humans and is associated with high morbidity, mortality and health-related expenses. Computational approaches have been increasingly utilized in atrial electrophysiology. In this review we summarize the recent advancements in atrial fibrillation modeling at the organ scale. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2019.01.096DOI Listing
January 2019

An unusual presentation of late-onset Alexander's disease with slow orthostatic tremor and a novel GFAP variant.

Neurocase 2019 Feb 12:1-3. Epub 2019 Feb 12.

a Department of Neurology , Mayo Clinic , Rochester , MN , USA.

Alexander disease (AxD) is a leukodystrophy, described in infantile, juvenile and adult onset forms, due to mutations in the glial fibrillary acid protein (GFAP) gene. Adult-onset AxD (AOAD) has a range of clinical and radiographic phenotypes with the oldest reported onset in the seventh decade.We report a case of AOAD, with onset in the eighth decade, presenting with slow variant orthostatic tremor, which has not been previously described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13554794.2019.1580749DOI Listing
February 2019

Proteomic analysis reveals temporal changes in protein expression in human induced pluripotent stem cell-derived cardiomyocytes in vitro.

Stem Cells Dev 2019 Feb 13. Epub 2019 Feb 13.

Imperial College, NHLI , Dovehouse St , London, United Kingdom of Great Britain and Northern Ireland , SW3 6LY ;

Human induced pluripotent stem cell-derived cardiomyocytes hold great promise for regenerative medicine and in vitro screening. Despite displaying key cardiomyocyte phenotypic characteristics, they more closely resemble foetal/neonatal cardiomyocytes and further characterisation is necessary. Combining the use of tandem mass tags to label cell lysates, followed by multiplexing, we have determined the effects of short term (30 day) in vitro culture on human induced pluripotent stem cell derived cardiomyocyte protein expression. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/scd.2018.0210
Publisher Site
http://dx.doi.org/10.1089/scd.2018.0210DOI Listing
February 2019
3 Reads

His Bundle Pacing Themed Issue.

Authors:
Paul J Wang

Circ Arrhythm Electrophysiol 2019 Feb;12(2):e007209

Editor-in-Chief, Circulation: Arrhythmia and Electrophysiology.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.119.007209DOI Listing
February 2019

Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart.

Europace 2019 Feb 8. Epub 2019 Feb 8.

Institute of Cardiovascular Science, University College London, London, UK.

Aims: Action potential duration (APD) alternans is an established precursor or arrhythmia and sudden cardiac death. Important differences in fundamental electrophysiological properties relevant to arrhythmia exist between experimental models and the diseased in vivo human heart. To investigate mechanisms of APD alternans using a novel approach combining intact heart and cellular cardiac electrophysiology in human in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/europace/euz007DOI Listing
February 2019
1 Read

In-Vivo Ratiometric Optical Mapping Enables High-Resolution Cardiac Electrophysiology in Pig Models.

Cardiovasc Res 2019 Feb 7. Epub 2019 Feb 7.

Spanish National Cardiovascular Research Center, Carlos III (CNIC), Madrid, Spain.

Aims: Cardiac optical mapping is the gold standard for measuring complex electrophysiology in ex-vivo heart preparations. However, new methods for optical mapping in-vivo have been elusive. We aimed at developing and validating an experimental method for performing in-vivo cardiac optical mapping in pig models. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/cardiovascres/advance-article/doi/1
Publisher Site
http://dx.doi.org/10.1093/cvr/cvz039DOI Listing
February 2019
1 Read

Probabilistic Encoding Models for Multivariate Neural Data.

Front Neural Circuits 2019 28;13. Epub 2019 Jan 28.

Queensland Brain Institute and School of Mathematics and Physics, The University of Queensland, Brisbane, QLD, Australia.

A key problem in systems neuroscience is to characterize how populations of neurons encode information in their patterns of activity. An understanding of the encoding process is essential both for gaining insight into the origins of perception and for the development of brain-computer interfaces. However, this characterization is complicated by the highly variable nature of neural responses, and thus usually requires probabilistic methods for analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fncir.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360288PMC
January 2019

α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling.

Front Neurosci 2019 28;13:28. Epub 2019 Jan 28.

School of Life Sciences, Liaocheng University, Liaocheng, China.

α-synuclein (α-Syn) is a presynaptic enriched protein involved in the pathogenesis of Parkinson's disease. However, the physiological roles of α-Syn remain poorly understood. Recent studies have indicated a critical role of α-Syn in the sensing and generation of membrane curvature during vesicular exocytosis and endocytosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2019.00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360911PMC
January 2019
1 Read

Melanocortin type 4 receptor-mediated inhibition of A-type K current enhances sensory neuronal excitability and mechanical pain sensitivity in rats.

J Biol Chem 2019 Feb 11. Epub 2019 Feb 11.

Soochow University, China.

Alpha-melanocyte-stimulating hormone (α-MSH) has been shown to be involved in nociception, but the underlying molecular mechanisms remain largely unknown. In this study, we report that α-MSH suppresses the transient outward A-type K current () in trigeminal ganglion (TG) neurons and thereby modulates neuronal excitability and peripheral pain sensitivity in rats. Exposing small-diameter TG neurons to α-MSH concentration-dependently decreased This α-MSH-induced decrease was depended on the melanocortin type 4 receptor (MC4R) and associated with a hyperpolarizing shift in the voltage dependence of A-type K channel inactivation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA118.006894DOI Listing
February 2019
4.573 Impact Factor

Year in Review in Cardiac Electrophysiology.

Circ Arrhythm Electrophysiol 2019 Feb;12(2):e007142

Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, MN (M.M., S.K.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.118.007142DOI Listing
February 2019
1 Read

Impaired cognitive flexibility following NMDAR-GluN2B deletion is associated with altered orbitofrontal-striatal function.

Neuroscience 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurosciences, University of New, Mexico, School of Medicine, Albuquerque, NM; New, Mexico, Alcohol Research Center, UNM Health Sciences Center, Albuquerque, NM. Electronic address:

A common feature across neuropsychiatric disorders is inability to discontinue an action or thought once it has become detrimental. Reversal learning, a hallmark of executive control, requires plasticity within cortical, striatal and limbic circuits and is highly sensitive to disruption of N-methyl--aspartate receptor (NMDAR) function. In particular, selective deletion or antagonism of GluN2B containing NMDARs in cortical regions including the orbitofrontal cortex (OFC), promotes maladaptive perseveration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2019.01.066DOI Listing
February 2019
1 Read

Correlation Structure in Micro-ECoG Recordings is Described by Spatially Coherent Components.

PLoS Comput Biol 2019 Feb 11;15(2):e1006769. Epub 2019 Feb 11.

Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, United States of America.

Electrocorticography (ECoG) is becoming more prevalent due to improvements in fabrication and recording technology as well as its ease of implantation compared to intracortical electrophysiology, larger cortical coverage, and potential advantages for use in long term chronic implantation. Given the flexibility in the design of ECoG grids, which is only increasing, it remains an open question what geometry of the electrodes is optimal for an application. Conductive polymer, PEDOT:PSS, coated microelectrodes have an advantage that they can be made very small without losing low impedance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1006769DOI Listing
February 2019

Automated microfluidic cell culture of stem cell derived dopaminergic neurons.

Sci Rep 2019 Feb 11;9(1):1796. Epub 2019 Feb 11.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 avenue des Hauts-Fourneaux, L-4362, Esch-sur-Alzette, Luxembourg.

Parkinson's disease is a slowly progressive neurodegenerative disease characterised by dysfunction and death of selectively vulnerable midbrain dopaminergic neurons and the development of human in vitro cellular models of the disease is a major challenge in Parkinson's disease research. We constructed an automated cell culture platform optimised for long-term maintenance and monitoring of different cells in three dimensional microfluidic cell culture devices. The system can be flexibly adapted to various experimental protocols and features time-lapse imaging microscopy for quality control and electrophysiology monitoring to assess cellular activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-34828-3DOI Listing
February 2019
1 Read

Electroanatomic mapping-guided catheter ablation of atrial tachycardia in children with limited/zero fluoroscopy.

Pacing Clin Electrophysiol 2019 Feb 10. Epub 2019 Feb 10.

Department of Pediatric Cardiology/Electrophysiology, Istanbul Medipol University Hospital, Istanbul, Turkey.

Introduction: Atrial tachycardia (AT) is an uncommon cause of supraventricular tachycardia in children and it is often resistant to medical therapy. Catheter ablation can be curative in children with AT. However, experience of ablation of pediatric AT is still very limited. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pace.13619
Publisher Site
http://dx.doi.org/10.1111/pace.13619DOI Listing
February 2019
2 Reads

Spontaneously alternating narrow-wide-narrow QRS complex tachycardias: What is the mechanism?

Pacing Clin Electrophysiol 2019 Feb 10. Epub 2019 Feb 10.

Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pace.13620DOI Listing
February 2019

Is epicardial fat tissue associated with atrial fibrillation recurrence after ablation? A systematic review and meta-analysis.

Int J Cardiol Heart Vasc 2019 Mar 26;22:132-138. Epub 2019 Jan 26.

Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.

Introduction: Although an undoubted association between epicardial fat tissue (EFT) and atrial fibrillation (AF) has been recently approved, the association between EFT and post-ablation AF recurrence is not evident yet. This study aimed to assess the association between EFT and AF recurrence after ablation.

Methods: The present study was a systematic review and meta-analysis using related literature available in electronic databases until July 2018 via "atrial fibrillation" and "epicardial fat" as the main keywords. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcha.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356021PMC
March 2019
1 Read

Muscular Ultrasound, Syndecan-1 and Procalcitonin Serum Levels to Assess Intensive Care Unit-Acquired Weakness.

Can J Neurol Sci 2019 Feb 11:1-9. Epub 2019 Feb 11.

Department of Anaesthesiology and Intensive Care Medicine,University Medical,Center Rostock, Rostock,Germany.

Background: Intensive care unit-acquired weakness (ICU-AW) is associated with poorer outcome of critically ill patients. Microcirculatory changes and altered vascular permeability of skeletal muscles might contribute to the pathogenesis of ICU-AW. Muscular ultrasound (MUS) displays increased muscle echogenicity, although its pathogenesis is uncertain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/cjn.2018.390DOI Listing
February 2019

Permanent damage of the sciatic nerve in an 8-year-old girl with newly diagnosed type 1 diabetes.

Paediatr Int Child Health 2019 Feb 11:1-3. Epub 2019 Feb 11.

a 4th Department of Pediatrics, School of Medicine, Faculty of Health Sciences , Aristotle University of Thessaloniki, Papageorgiou General Hospital , Thessaloniki , Greece.

Neuropathy, a complication of type 1 diabetes (T1D), is a heterogeneous group, and chronic polyneuropathy is the most common form in adults. Αn 8-year-old girl admitted with severe diabetic ketoacidosis was diagnosed with T1D. She was managed with intravenous fluids and insulin and was subsequently commenced on multiple daily subcutaneous injections of insulin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/20469047.2019.1575536DOI Listing
February 2019
1 Read

Direct Visualization of the His Bundle Pacing Lead Placement by 3-Dimensional Electroanatomic Mapping.

Circ Arrhythm Electrophysiol 2019 Feb;12(2):e006801

Department of Medicine, Division of Cardiology, Section of Electrophysiology, St. Elizabeth's Medical Center, Boston, MA (M.V.O., I.K. M.M., A.E., A.H., J.A., J.V.W.).

Background: His bundle pacing (HBP) remains technically challenging and is currently guided by electrograms and 2-dimensional fluoroscopy. Our objective was to describe a new technique for HBP directly guided by electroanatomic mapping (EAM).

Methods: Twenty-eight patients were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.118.006801DOI Listing
February 2019
1 Read

Women in Cardiology in Australia-Are We Making Any Progress?

Heart Lung Circ 2019 Jan 24. Epub 2019 Jan 24.

Department of Cardiology, Northern, Melbourne, Victoria, Australia.

Women remain largely under-represented in cardiology worldwide, despite gender parity among medical graduates. This is particularly notable in procedural subspecialties such as interventional cardiology and electrophysiology and is consistent at all levels of training. Cardiology continues to have the lowest proportion of females of all adult medicine specialties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hlc.2018.12.010DOI Listing
January 2019

Effective chair training methods for neuroscience research involving rhesus macaques (Macaca mulatta).

J Neurosci Methods 2019 Feb 6. Epub 2019 Feb 6.

Department of Experimental Psychology, University of Oxford, Oxford, OX1 3SR, United Kingdom. Electronic address:

Background: Neuroscience research using macaques remains fundamental in our endeavours to understand how the human brain functions. Applying the refinement principle of the 3Rs is essential to optimise the monkeys' welfare and still produces high quality science.

New Method: Here we document refinements in our training methods for acclimation to transport devices (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneumeth.2019.02.001DOI Listing
February 2019

Mid-ventricular obstructive hypertrophic cardiomyopathy with apical aneurysm: An important subtype of arrhythmogenic cardiomyopathy.

Ann Noninvasive Electrocardiol 2019 Feb 9:e12638. Epub 2019 Feb 9.

Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/anec.12638DOI Listing
February 2019
1 Read

The impact of dihydropyridine derivatives on the cerebral blood flow response to somatosensory stimulation and spreading depolarization.

Br J Pharmacol 2019 Feb 9. Epub 2019 Feb 9.

Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged; Koranyi fasor 9, H-6721, Szeged, Hungary.

Background And Purpose: A new class of heat shock protein co-inducer dihydropyridine derivatives devoid of calcium channel antagonist and vasodilator effects have been recently developed with the purpose to target neurodegeneration selectively. Here we set out to evaluate the action of one of these novel compounds LA1011 on neurovascular coupling in the ischemic rat cerebral cortex. As a reference, we applied nimodipine, a well-known calcium channel antagonist, vasodilator dihydropyridine compound. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.14611DOI Listing
February 2019

Strengthened inputs from secondary motor cortex to striatum in a mouse model of compulsive behavior.

J Neurosci 2019 Feb 8. Epub 2019 Feb 8.

Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA

Hyperactivity in striatum is associated with compulsive behaviors in Obsessive-Compulsive Disorder (OCD) and related illnesses, but it is unclear if this hyperactivity is due to intrinsic striatal dysfunction or abnormalities in corticostriatal inputs. Understanding the cellular and circuit properties underlying striatal hyperactivity could help inform the optimization of targeted stimulation treatments for compulsive behavior disorders. To investigate the cellular and synaptic abnormalities that may underlie corticostriatal dysfunction relevant to OCD, we utilized the Sapap3 knockout (Sapap3-KO) mouse model of compulsive behaviors, which also exhibits hyperactivity in central striatum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.1728-18.2018DOI Listing
February 2019
2 Reads

Chronic Stress Causes Projection-Specific Adaptation of Amygdala Neurons via Small-Conductance Calcium-Activated Potassium Channel Downregulation.

Biol Psychiatry 2018 Dec 20. Epub 2018 Dec 20.

Laboratory of Fear and Anxiety Disorders, Institutes of Life Science, Nanchang University, Nanchang, China; Department of Neurology, Second Affiliated Hospital, Nanchang University, Nanchang, China. Electronic address:

Background: The role of the amygdala in mediating stress coping has been long appreciated. However, basolateral amygdala (BLA) projection neurons (PNs) are organized into discrete output circuits, and it remains unclear whether stress differentially impacts these circuits.

Methods: Mice were exposed to acute restraint stress or chronic restraint stress (CRS), and c-fos expression was measured as a proxy for neuronal activation in Retrobead retrogradely labeled dorsomedial prefrontal cortex-targeting PNs (BLA→dmPFC) and non-dmPFC-targeting PNs (BLA↛dmPFC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopsych.2018.12.010DOI Listing
December 2018
1 Read

The sympathetic nervous system and arrhythmogenic right ventricular cardiomyopathy: Further evidence of a strong tie.

Heart Rhythm 2019 Feb 5. Epub 2019 Feb 5.

Department of Molecular Medicine, Section of Cardiology, University of Pavia, Pavia, Italy; Cardiac Intensive Care Unit, Arrhythmia and Electrophysiology and Experimental Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2019.02.004DOI Listing
February 2019
1 Read

The association of CHA2DS2-VASc score and carotid plaque in patients with non-valvular atrial fibrillation.

PLoS One 2019 8;14(2):e0210945. Epub 2019 Feb 8.

Department of Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.

Objective: The aim of this study was to assess the association between CHA2DS2-VASc score and carotid plaques in patients with non-valvular atrial fibrillation (NVAF).

Methods: We conducted a retrospective study including 3,435 NVAF patients who underwent carotid ultrasound examinations from January 2015 to December 2017.We collected the clinical data on the medical records system. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210945PLOS
February 2019
1 Read
3.234 Impact Factor