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Rinsho Shinkeigaku 2020 May 18;60(5):346-350. Epub 2020 Apr 18.

Department of Neurology, Dokkyo Medical University.

A 68-year-old woman was referred to our hospital for progressive dizziness, gait disturbances and weight loss for 18 months. The patient was alert and showed dysphagia and a marked tendency to fall backward. Electronystagmography showed bilateral vestibular dysfunction and audiometry showed right sensorineural hearing disturbance. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;34(2):186-189

Vertical nystagmus is a vertical nystagmus caused by structural abnormalities and/or dysfunction of the central vestibular system and observed in situ in the center of the eyeball. There are two kinds of nystagmus （UBN） and downbeat nystagmus （DBN） according to the direction of nystagmus. The diagnosis of UBN is mainly made by naked eye or electronystagmography/viewer. Read More

Front Neurol 2019 10;10:1341. Epub 2020 Jan 10.

Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Antwerp, Belgium.

Radiologic abnormalities on computed tomography (CT), including narrowing or sclerosis of the semicircular canals (SCCs), and T2-weighted magnetic resonance imaging (MRI), including signal loss in the SCC, have been reported as potential biomarkers in patients with P51S mutations in the gene (i.e., DFNA9). Read More

Endocrine 2020 Mar 4;67(3):659-664. Epub 2020 Jan 4.

Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, 49060-100, Brazil.

Purpose: Body balance involves the vestibular, visual, and proprioceptive systems. IGF-I is a GH-dependent key factor in the development and postnatal differentiation of the inner ear in mice and men, but its role in the vestibular function in adult humans is unknown. We have previously described a cohort of individuals with severe isolated GH deficiency (IGHD) caused by a mutation in the GHRH receptor (GHRHR) gene. Read More

Strabismus 2020 03 31;28(1):3-6. Epub 2019 Dec 31.

Children's Eye Disease and Ocular Motility Institute of Purui Jina, Shandong Purui Liangkang Eye Hospital, Jinan, Shandong Province, P. R. China.

: To establish a relation between pendular low amplitude high frequency (PLAHF) components and congenital retinal disorders.: Patients who showed PLAHF components in their eye-movement recording between January 2016 to January 2019 were included. Best corrected visual acuity (BCVA), refraction, strabismus assessment, fundus photograph, spectral domain-optical coherence tomography (SD-OCT), full-field electroretinography (f-ERG), clinical ophthalmological examination, and gene tests were used to determine their clinical conditions, especially their retina conditions in all patients. Read More

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Dec 3. Epub 2019 Dec 3.

Department of Neurology, 2 nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.

Aims: Preoperative chemical vestibular ablation can reduce vestibular symptoms in patients who have gone through vestibular schwannoma resection. The goal of this study was to determine whether chemical vestibular prehabituation influences the patients' post-operative perception of visual stimulation, mental status and quality of life. We also tried to find out whether increases of optokinetic nystagmus, measured by routine electronystagmography, correlate with subjective symptoms. Read More

Indian J Otolaryngol Head Neck Surg 2019 Dec 18;71(4):453-463. Epub 2019 Feb 18.

Present Address: Department of Otorhinolaryngology, Nepalgunj Medical College, Nepalgunj, Nepal.

The central pathologies present with perverted auditory perception and compromised postural control. Considering the existing controversy this study involves assessments of 100 cases of post fossa tumefactions in which a detailed clinical and neuro-otological (pure tone audiometry, electronystagmography, brainstem evoked response audiometry) profile is compared with their imaging patterns. The CP angle schwannomas (N = 26) presented with abnormal speech tests (N = 18), abnormal auditory adaptation (N = 7) and ABR with pathologically increased latency of wave V (N = 32), poor formation of wave I (N = 31) along with abnormal inter-wave interval (N = 32). Read More

J Vestib Res 2019;29(6):309-314

Santa Casa de Sao Paulo School of Medical Sciences, CEP 01221-010 São Paulo, SP, Brasil.

Objective: To measure the time required in patients with tympanic perforation to reverse paradoxical stimulation (reverse pseudo-nystagmus) and to create a physical model of the process.

Method: An analytical, observational, cross-sectional study with vestibular evaluation (electronystagmography) of 52 individuals with tympanic membrane perforation without otorrhea or concomitant disease. Increased duration of caloric stimulation in the presence of paradoxical stimulation (reverse pseudo-nystagmus) reverses nystagmic responses. Read More

Comput Biol Med 2019 11 17;114:103448. Epub 2019 Sep 17.

Norfolk & Norwich University Hospitals NHS Foundation Trust, Norwich, NR4 7UY, United Kingdom.

Symptoms of dizziness or imbalance are frequently reported by people over 65. Dizziness is usually episodic and can have many causes, making diagnosis problematic. When it is due to inner-ear malfunctions, it is usually accompanied by abnormal eye-movements called nystagmus. Read More

Otolaryngol Head Neck Surg 2019 12 1;161(6):1027-1030. Epub 2019 Oct 1.

Department of Otolaryngology-Head and Neck Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Objective: Unilateral vestibular weakness has considerable potential etiologies. One source is a vestibular schwannoma. This article evaluates, in the absence of other symptoms and signs, if unilateral vestibular weakness is an analogue to asymmetric sensorineural hearing loss and serves as an indication for lateral skull base imaging. Read More

Eur Arch Otorhinolaryngol 2019 Dec 7;276(12):3513-3517. Epub 2019 Sep 7.

Hadassah Hebrew-University School of Medicine, Jerusalem, Israel.

Objective: Vertigo is a complex symptom which imposes diagnostic and treatment challenges. Laboratory evaluation of vertigo includes video-nystagmography (VNG) and computerized dynamic posturography (CDP) for the evaluation of different aspects of this complaint. There are vague indications for each test and potential disagreements between them. Read More

J Laryngol Otol 2019 Jul 14;133(7):554-559. Epub 2019 Jun 14.

Hearing and Balance Center, Our Lady of the Lake Regional Medical Center, Baton Rouge, USA.

Objective: To determine whether central findings from vestibular tests predict abnormal findings on magnetic resonance imaging.

Method: This study was a retrospective case series at a tertiary referral centre. The main outcome measure of this diagnostic intervention study was the positive predictive value of central vestibular findings in relation to magnetic resonance imaging abnormalities. Read More

Acta Otolaryngol 2019 Jul 20;139(7):581-587. Epub 2019 May 20.

a Department of Otolaryngology , Tokyo Medical and Dental University , Tokyo , Japan.

The thickness of Listing's plane accurately reflects gravitational recognition, constructed through the integration of visual, vestibular, and proprioceptive sensory input in the neural integrator of the central nervous system. Spinocerebellar degeneration (SCD) is a progressive degenerative disease mainly involving the cerebellum and brainstem that leads to destabilize the gravitational recognition, and may thicken thickening of Listing's plane. The aim of this study is to evaluate the gravitational recognition in response to positional change in patients with SCD, using the thickness of Listing's plane as a parameter. Read More

Iran J Otorhinolaryngol 2019 Mar;31(103):103-107

Markazi Vestibular Assessment and Rehabilitation Center, Mashhad, Iran.

Introduction: Vestibular abnormalities are common problems in the whole world, which can lead to bilateral vestibular dysfunction (BVD). That results in symptoms, such as vertigo, unsteadiness, falling, oscillopsia, and lower quality of life. The Objective of this study was to determine BVD in adults and elderlies with vertigo and unsteadiness. Read More

Adv Otorhinolaryngol 2019 15;82:32-38. Epub 2019 Jan 15.

Videonystagmography (VNG) and posturography are two vestibular assessment techniques that are still in use today. VNG: VNG allows clinicians to observe and record eye movements in real-time. Compared with electronystagmography (ENG), VNG tracings are more detailed and can capture subtle clinical findings. Read More

Acta Otorhinolaryngol Ital 2019 Feb;39(1):46-52

Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Postgraduate Medical School.

Eur J Paediatr Neurol 2019 03;23(2):232

Department of Clinical and Experimental Medicine, University of Messina, Via Bivona, Messina, Italy. Electronic address:

Tex Med 2019 Feb 1;115(2):32-33. Epub 2019 Feb 1.

In a split victory, TMA once again prevailed in November 2018 when the Third Court of Appeals upheld a trial court's decision that chiropractors don't have the authority to perform vestibular-ocular-nystagmus testing (VONT). However, a recent change to state law caused the appeals court to find in the Texas Board of Chiropractic Examiners' favor on the use of the word "diagnosis" in the board's administrative rules - meaning chiropractors can diagnose, but only within their scope of practice. Read More

Arq Neuropsiquiatr 2019 01;77(1):25-32

Universidade Federal de Santa Maria, Departamento de Fonoaudiologia, Santa Maria, RS, Brasil.

Objective: Changes in postural balance and visual complaints are frequent consequences of stroke. We aimed to investigate the symptoms and the vestibular and oculomotor functions of patients with dizziness post ischemic and hemorrhagic stroke and compare the results among them.

Methods: Fifty patients with dizziness after stroke were evaluated through a clinical anamnesis and computerized vector electronystagmography: calibration of ocular movements, spontaneous nystagmus, semi-spontaneous nystagmus, pendular tracking, optokinetic nystagmus, rotary chair testing, and the caloric test. Read More

Am J Transl Res 2018 15;10(11):3650-3663. Epub 2018 Nov 15.

Shanghai University of TCM Shanghai 201203, China.

The aim of this study was to investigate the protective effects of vincamine in endolymphatic hydrops (ELH). After ELH guinea pigs treated by vincamine, the concentration of VAP in plasma, and the levels of cAMP, MDA, SOD, GSH-Px in right cochlea were measured using spectrophotometric method. The V2R, NMDAR1, p-NMDAR1, AQP2, p-AQP2, caspase3/9 and c-caspase3/9 expressions in right cochlea were detected using western blot analysis. Read More

Eur J Paediatr Neurol 2019 Mar 18;23(2):262-269. Epub 2018 Dec 18.

Rett Expertise Center - Governor Kremers Center, Maastricht University Medical Center, Maastricht, the Netherlands; Division of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, Netherlands; Faculty of Physics, Tomsk State University, Tomsk, Russia. Electronic address:

Background: Rett syndrome (RTT) is a neurological disorder characterized by a broad spectrum of symptoms. Communication is a major area of difficulty. Use of eye tracking technology offers a potentially effective method of communication when underpinned by intact oculomotor function. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;53(12):888-892

Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Center Hospital, Otorhinolaryngology Institute of Tianjin, Tianjin 300192, China.

To analyze the characteristics of nystagmus of horizontal semicircular canal cupulolithiasis(HSC-Cup) in Roll test and Dix-Hallpike test. Between December 2016 and December 2017, a total of 164 patients with BPPV from Tianjin First Center Hospital, 124 HSC-Can BPPV and 40 HSC-Cup BPPV, were involved.The induced nystagmus in Roll test and Dix-Hallpike test were recorded by video-nystagmograph(VNG), whose direction and intensity characteristics were compared in various BPPV. Read More

Auris Nasus Larynx 2019 Aug 17;46(4):636-640. Epub 2018 Dec 17.

Department of Otolaryngology, Toho University Sakura Medical Center, 564-1 Shimo-shizu, Sakura City, Chiba 285-0841, Japan.

Aim: To report the effect of oval and round window reinforcement surgery performed in two patients with the Tullio phenomenon. Case 1: A male with bilateral superior canal dehiscence syndrome. Downbeat nystagmus with leftward horizontal eye movement was recorded in an electronystagmogram using a pure-tone sound of 110dB at 2000 or 4000Hz in the right ear. Read More

Nat Commun 2018 12 18;9(1):5374. Epub 2018 Dec 18.

Key Laboratory for Biomedical Engineering of Ministry of Education, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, College of Biomedical Engineering and Instrument Sciences, Zhejiang University, 310027, Hangzhou, China.

The sensory and motor systems jointly contribute to complex behaviors, but whether motor systems are involved in high-order perceptual tasks such as speech and auditory comprehension remain debated. Here, we show that ocular muscle activity is synchronized to mentally constructed sentences during speech listening, in the absence of any sentence-related visual or prosodic cue. Ocular tracking of sentences is observed in the vertical electrooculogram (EOG), whether the eyes are open or closed, and in eye blinks measured by eyetracking. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1491-1494

Department of Otolaryngology, Kuang Tien General Hospital, Taichung, Taiwan.

To observe the characteristics of positional nystagmus and clinical profile of patients with positive positional test, and to explore its possible pathogenesis. One hundred and twenty-one patients with positive positional test in the vestibular function examination were enrolled in the Peking University International Hospital from January to June in 2017. According to the 2017 BPPV guidelines, patients with test positive positional nystagmus were divided into two groups: definite BPPV and the controversial syndrome. Read More

Pediatr Neurol 2018 11 30;88:48-58. Epub 2018 Aug 30.

Rett Expertise Centre Netherlands - GKC, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: Individuals with Rett syndrome (RTT) are notoriously reliant on the use of eye gaze as a primary means of communication. Underlying an ability to communicate successfully via eye gaze is a complex matrix of requirements, with an intact oculomotor system being just one element. To date, the underlying neural and motor pathways associated with eye gaze are relatively under-researched in RTT. Read More

J Binocul Vis Ocul Motil 2018 Oct-Dec;68(4):122-133. Epub 2018 Oct 17.

a Daroff-Dell'Osso Ocular Motility Laboratory, Louis Stokes Cleveland Department of Veterans Affairs Medical Center and Department of Neurology, CASE Medical School, Cleveland, Ohio.

Introduction And Purpose: To demonstrate the utility of using eye-movement data to reveal the diagnostic characteristics of infantile nystagmus syndrome (INS), determine treatment, and both estimate and document therapeutic improvements in three patients with well-developed foveation periods, fairly broad, lateral gaze "nulls," head turns, strabismus, and complex, multiplanar nystagmus.

Patients And Methods: Infrared reflection, magnetic search coil, and high-speed digital video systems were used to record the eye movements of INS patients, pre- and post-Kestenbaum null-point correction surgery (horizontal or vertical). Data were analyzed and estimations made, using the eXpanded Nystagmus Acuity Function (NAFX) that is part of the OMtools toolbox for MATLAB. Read More

Indian J Otolaryngol Head Neck Surg 2018 Sep 13;70(3):428-433. Epub 2018 Jul 13.

2Department of ENT, MGM Medical College and MY Hospital, Indore, M.P. India.

Elderly population is frequently affected by vertigo which affects their mobility and makes them vulnerable to fall and other morbidities. Often these patient visit neurologist and are often subjected to CT scan, MRI brain etc. to rule out a central cause of vertigo; whereas majority of these patients suffer from vestibular cause of vertigo. Read More

J Laryngol Otol 2018 Sep 28;132(9):771-774. Epub 2018 Aug 28.

Department of Otolaryngology - Head and Neck Surgery,Christchurch Hospital,University of Canterbury and University of Otago,Christchurch,New Zealand.

Background: The cause of Ménière's disease remains enigmatic after 156 years. Schuknecht's rupture and potassium intoxication theory of attacks was based on histological studies.

Objectives: This paper aimed to: present the most contemporary evidence indicating that ruptures do not usually occur, and discuss the possibility that detached saccular otoconia are the main cause of Ménière's disease; and to establish an unequivocal definition of the age of Ménière's disease onset. Read More

Eur J Rheumatol 2018 Sep 22;5(3):201-202. Epub 2018 Jun 22.

Department of Neurology, University Healthcare Complex of Salamanca, Salamanca, Spain.

Treatment with anti-tumor necrosis factor alpha (anti-TNF α) drugs may lead to demyelinating polyneuropathies. Here, we present the case of a patient with rheumatic disease who developed sensory polyneuropathy probably related to anti-TNF α drugs. The patient was diagnosed with undifferentiated arthritis during treatment with weekly injection of golimumab. Read More

Pak J Med Sci 2018 May-Jun;34(3):558-563

Hakan Coskun, Uludag University Medical School, Department of Otolaryngology, Bursa, Turkey.

Objective: Benign paroxysmal positional vertigo (BPPV) is the most common peripheral cause of vertigo. It can be defined as transient vertigo induced by rapid change in head position, associated with a characteristic paroxysmal positional nystagmus. Posterior canal benign paroxysmal positional vertigo is the most frequent form of BPPV. Read More

Front Neurol 2018 11;9:396. Epub 2018 Jun 11.

Department of Otorhinolaryngology, Clinica Universidad de Navarra, Madrid, Spain.

Patients with inner ear damage associated with bilateral vestibular impairment often ask "how much damage do I have." Although there are presently three clinical methods of measuring semicircular canal vestibular function; electronystagmography (ENG or VENG), rotatory chair and video head-impulse (VHIT) testing; none of these methods provides a method of measuring total vestibular output. Theory suggests that the slow cumulative eye position can be derived from the rotatory chair test by multiplying the high frequency gain by the time constant, or the "Gain product. Read More

J Neuroophthalmol 2018 12;38(4):479-482

Departments of Neurology (TB, ND, WD, J-RR, JCR), Rehabilitation Medicine (J-RR) and Ophthalmology (JCR), New York University School of Medicine, New York, New York; and Department of Electrical and Computer Engineering (WD), New York University Tandon School of Engineering, New York, New York.

Otol Neurotol 2018 07;39(6):e468-e474

Department of Otolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.

Objective: To describe the vestibular function in patients with superficial siderosis of the central nervous system (SSCN).

Study Design: Retrospective analysis.

Setting: Tertiary referral center. Read More

J Diabetes Complications 2018 06 5;32(6):575-579. Epub 2018 Apr 5.

Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

Aims: The study was to investigate the hearing function in subjects with non-diabetic nephropathy and diabetic nephropathy and analyze related clinical indexes of hearing impairment.

Methods: We assessed the hearing function of 30 diabetics (DM group), 30 patients with early diabetic nephropathy (DN group) and 30 healthy subjects (NC group) using pure-tone audiometry, otoacoustic emissions, electronystagmography, caloric test and cervical vestibular evoked myogenic potential (VEMP).

Results: Pure-tone audiogram demonstrated a deficit at frequencies with elevated threshold in both DM and DN group (p < 0. Read More

Otolaryngol Pol 2018 Apr;72(2):45-49

Department of Otolaryngology and Laryngological Oncology 2nd Chair of Otolaryngology, Medical University of Lodz; Department and Chair Head: prof. J. Olszewski MD, PhD; Lodz, Poland.

Introduction: The aim of the study was to evaluate concurrent recording of ENG and VNG measurements in selected diagnostic tests in healthy subjects so as to explore potential sensitivity and applicability of this kind of testing in the diagnostics of vertigo.

Material And Methods: The study was carried out in 50 healthy subjects including 24 women and 26 men aged 20-22 (mean age of 20.5 years) reporting no otorhinolaryngological organ-related complaints and no history of any balance disorders or vertigo. Read More

Int J Pediatr Otorhinolaryngol 2018 Jun 19;109:13-16. Epub 2018 Mar 19.

Department and Clinic of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Poland.

Background: Otitis media with effusion (OME) is one of the most common clinical conditions in childhood. Fluid accumulation in the middle ear may impact inner ear.

Objectives: The purpose of this random sample cohort study was to investigate whether the past history of middle ear effusion has a long-term negative impact on the vestibular system in children. Read More

Ear Nose Throat J 2018 Jan-Feb;97(1-2):16-23

Otoneurology Unit, Lin Medical Center, Rotschild Ave. 35, Haifa 3515209, Israel.

We conducted a study to compare how well the head impulse test (HIT), without and with eye-movement recordings, would predict videonystagmographic (VNG) caloric test lateralization when performed by a resident and an experienced otoneurologist. This prospective, open-label, blinded study was conducted in an ambulatory tertiary care referral center. Our study population was made up of 60 patients-29 men and 31 women, aged 20 to 82 years (mean: 56. Read More

Praxis (Bern 1994) 2018 Jan;107(2):87-93

1 Klinik für Neurologie, Kantonsspital St. Gallen.

Indian J Otolaryngol Head Neck Surg 2017 Dec 4;69(4):563-567. Epub 2017 Feb 4.

Department of ENT and Head-Neck Surgery, Hinduja Sindhi Hospital, Bengaluru, Karnataka 560027 India.

Migraine related vertigo (MRV) is largely accepted in the vestibular community and probably represents the second most common cause of vertigo after benign positional vertigo by far exceeding Meniere's disease. The data on vestibular migraine management is still relatively poor, despite its enormous importance in daily practice. A 55-year old male presented with history of giddiness, imbalance, sweating and sensation of nausea with severe pulsating headache of one day duration. Read More

Curr Opin Neurol 2018 Feb;31(1):111-116

Division of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Purpose Of Review: In the last decades, researchers suggested that clinical assessment of labyrinthine function in detail became easy thanks to video head impulse tests (VHITs), vestibular evoked myogenic potential test (VEMP) and video-oculography (VOG). It has been argued that they can replace electronystagmography, the caloric and rotatory chair tests. This review addresses the latest evaluations of these tests and the opportunities they offer, but also the limitations in clinical practice. Read More

Am J Otolaryngol 2018 Mar - Apr;39(2):180-183. Epub 2017 Nov 14.

Saint Louis University School of Medicine, Department of Otolaryngology - Head and Neck Surgery, 3635 Vista Ave., 6FDT, St. Louis, MO 63110, USA. Electronic address:

Purpose: Vestibular migraine is a common cause of dizziness that lacks a known objective test. This study examined total eye speed on caloric testing as a diagnostic marker for vestibular migraine.

Materials And Methods: Retrospective chart review of patients seen in a tertiary otologic practice between 2004 and 2016 who had undergone caloric testing with water irrigation and had a diagnosis of vestibular migraine (n=34). Read More

J Neuroophthalmol 2018 Mar;38(1):65-69

Department of Neurosurgery (PY-MW, ST, AC-HC, YC, H-TW, K-YC), Kwong Wah Hospital, Hong Kong, China; and School of Optometry (AM-YC), The Polytechnic University of Hong Kong, Hong Kong, China.

Seesaw nystagmus is characterized by cyclic eye movements with a conjugate torsional component and a dissociated vertical component. In the first half of the cycle, one eye elevates and intorts, whereas the other eye depresses and extorts. The pattern is reversed in the remaining half of the cycle. Read More

Auris Nasus Larynx 2018 Aug 28;45(4):866-870. Epub 2017 Oct 28.

Department of Otolaryngology - Head and Neck Surgery, Kyoto Prefectural University of Medicine, Japan.

Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) is a novel ataxic disorder consisting of the triad of cerebellar impairment, bilateral vestibular hypofunction, and a somatosensory deficit. We report the first Japanese case of CANVAS. The patient is a 68-year-old Japanese male. Read More

ORL J Otorhinolaryngol Relat Spec 2017 6;79(5):274-281. Epub 2017 Oct 6.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan, ROC.

Objective: This study reviewed our experience in treating sudden deafness in antepartum (pregnant) and postpartum women during the past 2 decades.

Methods: From 1997 to 2016, we have recorded sudden deafness in 16 antepartum (mean age, 32 years) and 3 postpartum (mean age, 31 years) women. Sudden deafness occurred during the 1st, 2nd, and 3rd trimesters in 5, 4, and 7 antepartum women, respectively. Read More

MMW Fortschr Med 2017 Sep;159(15):50-58

Klinik für Hals-Nasen-Ohrenheilkunde, Deutsches Schwindel- und Gleichgewichtszentrum, Ludwig-Maximilians-Universität München, Marchioninistr. 15, D-81377, München, Deutschland.

Intern Med 2017 Oct 15;56(20):2773-2778. Epub 2017 Sep 15.

Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Japan.

Glutamate receptor δ2 (GluRδ2) is expressed in the neuronal postsynaptic densities at the junctions between the Purkinje cells and the parallel fibers. Recent reports have described patients with opsoclonus who possess anti-GluRδ2 antibodies. We report the case of a 53-year-old man with opsoclonus whose cerebrospinal fluid was positive for anti-GluRδ2 antibodies. Read More

Otol Neurotol 2017 09;38(8):1145-1148

*Department of Head and Neck Surgery †Department of Neurology, University of California Los Angeles, Los Angeles, California.

Background: Bilateral vestibulopathy (BVP) is a debilitating condition characterized by gait ataxia, oscillopsia, and imbalance.

Objective: Case series of patients with migraine-linked vertigo spells and profound BVP. PATIENT 1:: A 69-year-old man presented with a history of recurrent severe vertigo spells lasting up to 3 days in duration associated with prostrating migraine headaches starting at age 60. Read More

Brain Struct Funct 2017 Dec 23;222(9):4163-4185. Epub 2017 Jun 23.

German Center for Vertigo and Balance Disorders, Ludwig-Maximilians-University, Feodor-Lynen-Str.19, 801377, Munich, Germany.

Optokinetic eye movements are crucial for keeping a stable image on the retina during movements of the head. These eye movements can be differentiated into a cortically generated response (optokinetic look nystagmus) and the highly reflexive optokinetic stare nystagmus, which is controlled by circuits in the brainstem and cerebellum. The contributions of these infratentorial networks and their functional connectivity with the cortical eye fields are still poorly understood in humans. Read More