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Eur J Paediatr Neurol 2019 Mar;23(2):232

Department of Clinical and Experimental Medicine, University of Messina, Via Bivona, Messina, Italy. Electronic address:

Tex Med 2019 Feb 1;115(2):32-33. Epub 2019 Feb 1.

In a split victory, TMA once again prevailed in November 2018 when the Third Court of Appeals upheld a trial court's decision that chiropractors don't have the authority to perform vestibular-ocular-nystagmus testing (VONT). However, a recent change to state law caused the appeals court to find in the Texas Board of Chiropractic Examiners' favor on the use of the word "diagnosis" in the board's administrative rules - meaning chiropractors can diagnose, but only within their scope of practice. Read More

Arq Neuropsiquiatr 2019 Jan;77(1):25-32

Universidade Federal de Santa Maria, Departamento de Fonoaudiologia, Santa Maria, RS, Brasil.

Objective: Changes in postural balance and visual complaints are frequent consequences of stroke. We aimed to investigate the symptoms and the vestibular and oculomotor functions of patients with dizziness post ischemic and hemorrhagic stroke and compare the results among them.

Methods: Fifty patients with dizziness after stroke were evaluated through a clinical anamnesis and computerized vector electronystagmography: calibration of ocular movements, spontaneous nystagmus, semi-spontaneous nystagmus, pendular tracking, optokinetic nystagmus, rotary chair testing, and the caloric test. Read More

Am J Transl Res 2018 15;10(11):3650-3663. Epub 2018 Nov 15.

Shanghai University of TCM Shanghai 201203, China.

The aim of this study was to investigate the protective effects of vincamine in endolymphatic hydrops (ELH). After ELH guinea pigs treated by vincamine, the concentration of VAP in plasma, and the levels of cAMP, MDA, SOD, GSH-Px in right cochlea were measured using spectrophotometric method. The V2R, NMDAR1, p-NMDAR1, AQP2, p-AQP2, caspase3/9 and c-caspase3/9 expressions in right cochlea were detected using western blot analysis. Read More

Eur J Paediatr Neurol 2019 Mar 18;23(2):262-269. Epub 2018 Dec 18.

Rett Expertise Center - Governor Kremers Center, Maastricht University Medical Center, Maastricht, the Netherlands; Division of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, Netherlands; Faculty of Physics, Tomsk State University, Tomsk, Russia. Electronic address:

Background: Rett syndrome (RTT) is a neurological disorder characterized by a broad spectrum of symptoms. Communication is a major area of difficulty. Use of eye tracking technology offers a potentially effective method of communication when underpinned by intact oculomotor function. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;53(12):888-892

Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Center Hospital, Otorhinolaryngology Institute of Tianjin, Tianjin 300192, China.

To analyze the characteristics of nystagmus of horizontal semicircular canal cupulolithiasis(HSC-Cup) in Roll test and Dix-Hallpike test. Between December 2016 and December 2017, a total of 164 patients with BPPV from Tianjin First Center Hospital, 124 HSC-Can BPPV and 40 HSC-Cup BPPV, were involved.The induced nystagmus in Roll test and Dix-Hallpike test were recorded by video-nystagmograph(VNG), whose direction and intensity characteristics were compared in various BPPV. Read More

Nat Commun 2018 12 18;9(1):5374. Epub 2018 Dec 18.

Key Laboratory for Biomedical Engineering of Ministry of Education, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, College of Biomedical Engineering and Instrument Sciences, Zhejiang University, 310027, Hangzhou, China.

The sensory and motor systems jointly contribute to complex behaviors, but whether motor systems are involved in high-order perceptual tasks such as speech and auditory comprehension remain debated. Here, we show that ocular muscle activity is synchronized to mentally constructed sentences during speech listening, in the absence of any sentence-related visual or prosodic cue. Ocular tracking of sentences is observed in the vertical electrooculogram (EOG), whether the eyes are open or closed, and in eye blinks measured by eyetracking. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1491-1494

Department of Otolaryngology, Kuang Tien General Hospital, Taichung, Taiwan.

To observe the characteristics of positional nystagmus and clinical profile of patients with positive positional test, and to explore its possible pathogenesis. One hundred and twenty-one patients with positive positional test in the vestibular function examination were enrolled in the Peking University International Hospital from January to June in 2017. According to the 2017 BPPV guidelines, patients with test positive positional nystagmus were divided into two groups: definite BPPV and the controversial syndrome. Read More

Pediatr Neurol 2018 Nov 30;88:48-58. Epub 2018 Aug 30.

Rett Expertise Centre Netherlands - GKC, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: Individuals with Rett syndrome (RTT) are notoriously reliant on the use of eye gaze as a primary means of communication. Underlying an ability to communicate successfully via eye gaze is a complex matrix of requirements, with an intact oculomotor system being just one element. To date, the underlying neural and motor pathways associated with eye gaze are relatively under-researched in RTT. Read More

Indian J Otolaryngol Head Neck Surg 2018 Sep 13;70(3):428-433. Epub 2018 Jul 13.

2Department of ENT, MGM Medical College and MY Hospital, Indore, M.P. India.

Elderly population is frequently affected by vertigo which affects their mobility and makes them vulnerable to fall and other morbidities. Often these patient visit neurologist and are often subjected to CT scan, MRI brain etc. to rule out a central cause of vertigo; whereas majority of these patients suffer from vestibular cause of vertigo. Read More

J Laryngol Otol 2018 Sep 28;132(9):771-774. Epub 2018 Aug 28.

Department of Otolaryngology - Head and Neck Surgery,Christchurch Hospital,University of Canterbury and University of Otago,Christchurch,New Zealand.

Background: The cause of Ménière's disease remains enigmatic after 156 years. Schuknecht's rupture and potassium intoxication theory of attacks was based on histological studies.

Objectives: This paper aimed to: present the most contemporary evidence indicating that ruptures do not usually occur, and discuss the possibility that detached saccular otoconia are the main cause of Ménière's disease; and to establish an unequivocal definition of the age of Ménière's disease onset. Read More

Eur J Rheumatol 2018 Sep 22;5(3):201-202. Epub 2018 Jun 22.

Department of Neurology, University Healthcare Complex of Salamanca, Salamanca, Spain.

Treatment with anti-tumor necrosis factor alpha (anti-TNF α) drugs may lead to demyelinating polyneuropathies. Here, we present the case of a patient with rheumatic disease who developed sensory polyneuropathy probably related to anti-TNF α drugs. The patient was diagnosed with undifferentiated arthritis during treatment with weekly injection of golimumab. Read More

Pak J Med Sci 2018 May-Jun;34(3):558-563

Hakan Coskun, Uludag University Medical School, Department of Otolaryngology, Bursa, Turkey.

Objective: Benign paroxysmal positional vertigo (BPPV) is the most common peripheral cause of vertigo. It can be defined as transient vertigo induced by rapid change in head position, associated with a characteristic paroxysmal positional nystagmus. Posterior canal benign paroxysmal positional vertigo is the most frequent form of BPPV. Read More

Front Neurol 2018 11;9:396. Epub 2018 Jun 11.

Department of Otorhinolaryngology, Clinica Universidad de Navarra, Madrid, Spain.

Patients with inner ear damage associated with bilateral vestibular impairment often ask "how much damage do I have." Although there are presently three clinical methods of measuring semicircular canal vestibular function; electronystagmography (ENG or VENG), rotatory chair and video head-impulse (VHIT) testing; none of these methods provides a method of measuring total vestibular output. Theory suggests that the slow cumulative eye position can be derived from the rotatory chair test by multiplying the high frequency gain by the time constant, or the "Gain product. Read More

Otol Neurotol 2018 Jul;39(6):e468-e474

Department of Otolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.

Objective: To describe the vestibular function in patients with superficial siderosis of the central nervous system (SSCN).

Study Design: Retrospective analysis.

Setting: Tertiary referral center. Read More

J Diabetes Complications 2018 Jun 5;32(6):575-579. Epub 2018 Apr 5.

Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

Aims: The study was to investigate the hearing function in subjects with non-diabetic nephropathy and diabetic nephropathy and analyze related clinical indexes of hearing impairment.

Methods: We assessed the hearing function of 30 diabetics (DM group), 30 patients with early diabetic nephropathy (DN group) and 30 healthy subjects (NC group) using pure-tone audiometry, otoacoustic emissions, electronystagmography, caloric test and cervical vestibular evoked myogenic potential (VEMP).

Results: Pure-tone audiogram demonstrated a deficit at frequencies with elevated threshold in both DM and DN group (p < 0. Read More

Otolaryngol Pol 2018 Apr;72(2):45-49

Department of Otolaryngology and Laryngological Oncology 2nd Chair of Otolaryngology, Medical University of Lodz; Department and Chair Head: prof. J. Olszewski MD, PhD; Lodz, Poland.

Introduction: The aim of the study was to evaluate concurrent recording of ENG and VNG measurements in selected diagnostic tests in healthy subjects so as to explore potential sensitivity and applicability of this kind of testing in the diagnostics of vertigo.

Material And Methods: The study was carried out in 50 healthy subjects including 24 women and 26 men aged 20-22 (mean age of 20.5 years) reporting no otorhinolaryngological organ-related complaints and no history of any balance disorders or vertigo. Read More

Int J Pediatr Otorhinolaryngol 2018 Jun 19;109:13-16. Epub 2018 Mar 19.

Department and Clinic of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Poland.

Background: Otitis media with effusion (OME) is one of the most common clinical conditions in childhood. Fluid accumulation in the middle ear may impact inner ear.

Objectives: The purpose of this random sample cohort study was to investigate whether the past history of middle ear effusion has a long-term negative impact on the vestibular system in children. Read More

Ear Nose Throat J 2018 Jan-Feb;97(1-2):16-23

Otoneurology Unit, Lin Medical Center, Rotschild Ave. 35, Haifa 3515209, Israel.

We conducted a study to compare how well the head impulse test (HIT), without and with eye-movement recordings, would predict videonystagmographic (VNG) caloric test lateralization when performed by a resident and an experienced otoneurologist. This prospective, open-label, blinded study was conducted in an ambulatory tertiary care referral center. Our study population was made up of 60 patients-29 men and 31 women, aged 20 to 82 years (mean: 56. Read More

Praxis (Bern 1994) 2018 Jan;107(2):87-93

1 Klinik für Neurologie, Kantonsspital St. Gallen.

Indian J Otolaryngol Head Neck Surg 2017 Dec 4;69(4):563-567. Epub 2017 Feb 4.

Department of ENT and Head-Neck Surgery, Hinduja Sindhi Hospital, Bengaluru, Karnataka 560027 India.

Migraine related vertigo (MRV) is largely accepted in the vestibular community and probably represents the second most common cause of vertigo after benign positional vertigo by far exceeding Meniere's disease. The data on vestibular migraine management is still relatively poor, despite its enormous importance in daily practice. A 55-year old male presented with history of giddiness, imbalance, sweating and sensation of nausea with severe pulsating headache of one day duration. Read More

Curr Opin Neurol 2018 Feb;31(1):111-116

Division of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Purpose Of Review: In the last decades, researchers suggested that clinical assessment of labyrinthine function in detail became easy thanks to video head impulse tests (VHITs), vestibular evoked myogenic potential test (VEMP) and video-oculography (VOG). It has been argued that they can replace electronystagmography, the caloric and rotatory chair tests. This review addresses the latest evaluations of these tests and the opportunities they offer, but also the limitations in clinical practice. Read More

Am J Otolaryngol 2018 Mar - Apr;39(2):180-183. Epub 2017 Nov 14.

Saint Louis University School of Medicine, Department of Otolaryngology - Head and Neck Surgery, 3635 Vista Ave., 6FDT, St. Louis, MO 63110, USA. Electronic address:

Purpose: Vestibular migraine is a common cause of dizziness that lacks a known objective test. This study examined total eye speed on caloric testing as a diagnostic marker for vestibular migraine.

Materials And Methods: Retrospective chart review of patients seen in a tertiary otologic practice between 2004 and 2016 who had undergone caloric testing with water irrigation and had a diagnosis of vestibular migraine (n=34). Read More

Auris Nasus Larynx 2018 Aug 28;45(4):866-870. Epub 2017 Oct 28.

Department of Otolaryngology - Head and Neck Surgery, Kyoto Prefectural University of Medicine, Japan.

Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) is a novel ataxic disorder consisting of the triad of cerebellar impairment, bilateral vestibular hypofunction, and a somatosensory deficit. We report the first Japanese case of CANVAS. The patient is a 68-year-old Japanese male. Read More

ORL J Otorhinolaryngol Relat Spec 2017 6;79(5):274-281. Epub 2017 Oct 6.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan, ROC.

Objective: This study reviewed our experience in treating sudden deafness in antepartum (pregnant) and postpartum women during the past 2 decades.

Methods: From 1997 to 2016, we have recorded sudden deafness in 16 antepartum (mean age, 32 years) and 3 postpartum (mean age, 31 years) women. Sudden deafness occurred during the 1st, 2nd, and 3rd trimesters in 5, 4, and 7 antepartum women, respectively. Read More

Intern Med 2017 Oct 15;56(20):2773-2778. Epub 2017 Sep 15.

Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Japan.

Glutamate receptor δ2 (GluRδ2) is expressed in the neuronal postsynaptic densities at the junctions between the Purkinje cells and the parallel fibers. Recent reports have described patients with opsoclonus who possess anti-GluRδ2 antibodies. We report the case of a 53-year-old man with opsoclonus whose cerebrospinal fluid was positive for anti-GluRδ2 antibodies. Read More

Otol Neurotol 2017 09;38(8):1145-1148

*Department of Head and Neck Surgery †Department of Neurology, University of California Los Angeles, Los Angeles, California.

Background: Bilateral vestibulopathy (BVP) is a debilitating condition characterized by gait ataxia, oscillopsia, and imbalance.

Objective: Case series of patients with migraine-linked vertigo spells and profound BVP. PATIENT 1:: A 69-year-old man presented with a history of recurrent severe vertigo spells lasting up to 3 days in duration associated with prostrating migraine headaches starting at age 60. Read More

Brain Struct Funct 2017 Dec 23;222(9):4163-4185. Epub 2017 Jun 23.

German Center for Vertigo and Balance Disorders, Ludwig-Maximilians-University, Feodor-Lynen-Str.19, 801377, Munich, Germany.

Optokinetic eye movements are crucial for keeping a stable image on the retina during movements of the head. These eye movements can be differentiated into a cortically generated response (optokinetic look nystagmus) and the highly reflexive optokinetic stare nystagmus, which is controlled by circuits in the brainstem and cerebellum. The contributions of these infratentorial networks and their functional connectivity with the cortical eye fields are still poorly understood in humans. Read More

Diving Hyperb Med 2017 Jun;47(2):123-126

Kitajima ENT Clinic, Tokyo, Japan.

A 28-year-old female diver presented with dizziness and difficulty clearing her left ear whilst scuba diving. Her pure-tone audiometry and tympanometry were normal. Testing of Eustachian tube function revealed tubal stenosis. Read More

Am J Transl Res 2017 15;9(5):2119-2131. Epub 2017 May 15.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityChongqing, China.

To explore the brainstem injury associated with supratentorial lesions, we conducted analysis of ICP levels and detected ENG parameters by using the cold caloric reflex test and histopathological examinations of the brainstem. Rat model of intracerebral hemorrhage was well-established in the study of supratentorial lesions of varying severities (n=210). Intracerebral pressure monitoring and electronystagmography of the cold caloric reflex test were simultaneously performed in animals. Read More

Int Tinnitus J 2017 Apr 19;20(2):93-101. Epub 2017 Apr 19.

Department of Otoneurology - Universidade Tuiuti do Parana - Curitiba - PR - Brazil.

Introduction: Spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative diseases that are characterized by the presence of progressive cerebellar ataxia.

Objective: Identify vestibular disorders and demonstrate the importance of labyrinthine examination in the prognosis and therapy for balance in patients with SCAs.

Materials And Methods: The study had a retrospective cross-sectional design and evaluated 57 patients, mean age of 41. Read More

J Am Acad Audiol 2017 Apr;28(4):314-324

Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN.

Background: Accurate measurement of oculomotor function using videonystagmography (VNG) is imperative for diagnosis and management of patients with reported dizziness. The oculomotor evaluation during VNG utilizes video-oculography providing valuable information regarding the central structures and pathways that control eye movements. Artifact may have an effect on the overall validity and reliability of VNG oculomotor tracings and can result from patient and/or recording errors. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Mar;52(3):200-204

Department of Otorhinolaryngology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.

To analyze the relationship between directional preponderance (DP), spontaneous nystagmus(SN) and vestibular disorders, and to investigate the significance of DP in directing peripheral vestibular function in patients with vertigo. This was a retrospective analysis of 394 cases diagnosed with peripheral vestibular disease accompanied by vertigo from March 2012 to June 2014 in the Outpatient Department of the Eye & ENT Hospital of Fudan University. Results of static and dynamic posture equilibrium tests, SN, unilateral weakness(UW), and DP in videonystagmography(VNG) were analyzed and compared. Read More

Ann Otol Rhinol Laryngol 2017 Apr 12;126(4):315-321. Epub 2017 Feb 12.

1 Hadassah-Hebrew University School of Medicine, Jerusalem, Israel.

Objects: Dizziness makes up a diagnostic and treatment challenge. The diagnostic accuracy of the medical history and vestibular physical examination in cases of vestibular symptoms is not clear. The aim of this study is to determine the association between vestibular physical examination, vestibular questionnaires, and electronystagmography (ENG) test in patients with vestibular symptoms. Read More

J Laryngol Otol 2017 Jun 2;131(6):508-513. Epub 2017 Mar 2.

Department of Surgery,Division of Otolaryngology - Head and Neck Surgery,Pennsylvania State University,College of Medicine,Hershey,USA.

Background: Benign paroxysmal positional vertigo and migraine-associated dizziness are common. The prevalence of benign paroxysmal positional vertigo seems to be higher in patients with migraine-associated dizziness than in those without migraine.

Methods: A database of 508 patients seen at the primary author's balance clinic was analysed to determine the prevalence of migraine, as defined by International Headache Society criteria, in patients with benign paroxysmal positional vertigo. Read More

PLoS One 2017 18;12(1):e0170011. Epub 2017 Jan 18.

Department of Otolaryngology, Head and Neck Surgery, Peking University First Hospital, Beijing, China.

Objectives: By analyzing the different phenotypes of two Chinese DFNA9 families with the same mutation located in the intervening region between the LCCL and vWFA domains of cochlin and testing the functional changes in the mutant cochlin, we investigated the different pathogeneses for mutations in LCCL and vWFA domains.

Methods: Targeted next-generation sequencing for deafness-related genes was used to identify the mutation in the proband in family #208. The probands of family #208 and family #32 with the same p. Read More

J Int Adv Otol 2017 Apr 13;13(1):100-104. Epub 2017 Jan 13.

Department of Otorhinolaryngology, Başkent University Alanya Hospital, Antalya, Turkey.

Objective: Idiopathic intracranial hypertension (IIH) can be manifested by audiological and vestibular complaints. The aim of the present study is to determine the audio-vestibular pathologies and their pathophysiologies in this syndrome by performing current audio-vestibular tests.

Materials And Methods: The study was performed prospectively on 40 individuals (20 IIH patients, 20 healthy volunteers). Read More

Workplace Health Saf 2017 Jan 20;65(1):4-8. Epub 2016 Dec 20.

1 California State University, Monterey Bay.

Vertigo is a disorder that affects equilibrium. Symptoms include a loss of balance with nausea and vomiting. Employees diagnosed with vertigo can return to work safely; however, they may need workplace restrictions and accommodation as symptoms may persist for months. Read More

Clin Otolaryngol 2017 Aug 1;42(4):815-823. Epub 2016 Dec 1.

Department of Operating Rooms, Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Currently, all patients presenting with asymmetrical sensorineural hearing loss and/or unilateral audiovestibular dysfunction (i.e. tinnitus, dizziness) undergo MRI, leading to a substantial amount of MRIs with negative findings as the incidence of vestibular schwannoma (VS) in this screening population varies between 1% and 4. Read More

Int J Oral Maxillofac Surg 2017 Mar 14;46(3):309-313. Epub 2016 Nov 14.

Department of Otorhinolaryngology, Baskent University School of Medicine, Ankara, Turkey.

The Le Fort I osteotomy is widely used to correct dentofacial deformities. Benign paroxysmal positional vertigo (BPPV) is a common vestibular end organ disorder characterized by short, often recurrent episodes of vertigo. Head trauma is one of the known causes of BPPV. Read More

Otol Neurotol 2017 01;38(1):110-113

Department of Otolaryngology-Head and Neck Surgery, Tokyo Medical and Dental University, Tokyo, Japan.

Objective: To clarify the direction and characteristics of nystagmus at the onset of a vertiginous attack in Ménière's disease.

Patients: Two patients with Ménière's disease, whose nystagmus at the onset of a vertiginous attack was recorded using electronystagmography.

Interventions: Diagnostic. Read More

J Laryngol Otol 2016 Nov 17;130(11):1033-1038. Epub 2016 Oct 17.

Department of Otolaryngology and Head - Neck Surgery,All India Institute of Medical Sciences,New Delhi,India.

Background: Laboratory experiments indicate that changes in retinal image size result in adaptive recalibration or suppression of the vestibulo-ocular reflex. Myopia correction with spectacles or contact lenses also leads to retinal image size changes, and may bring about similar vestibulo-ocular reflex alterations.

Methods: A hypothesis-generating preliminary investigation was conducted. Read More

J Int Adv Otol 2016 Aug;12(2):161-165

Department of Otorhinolaryngology, Yunus Emre State Hospital, Eskişehir, Turkey.

Objective: The aim of this study was to evaluate the vestibular system of children with unilateral sensorineural hearing loss (USNHL), investigate the etiological factors of USNHL and analyze whether a genetic predisposition exists.

Materials And Methods: Thirty-three children aged less than 18 years with USNHL, who visited the ear, nose, and throat (ENT) department between January 2004 and December 2012, were included in this study. Cases with conductive hearing loss were excluded from the study. Read More

Laryngoscope 2017 07 26;127(7):1698-1700. Epub 2016 Sep 26.

Department of Otolaryngology/Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.

Vertical nystagmus without a torsional component is generally considered a finding indicative of central nervous system pathology. We report two cases of purely upbeat nystagmus elicited with mastoid vibration after bilateral superior canal plugging, to highlight the vestibular pathophysiology involved in this unusual peripheral cause for upbeat nystagmus. Laryngoscope, 127:1698-1700, 2017. Read More

Handb Clin Neurol 2016 ;137:119-31

Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, USA.

The test of caloric thermal irrigations is one of the first tests for sensitivity of the peripheral vestibular systems dating to the late 1800s. This chapter reviews the various protocols that have been developed over the years using thermal irrigations to the external auditory canals. The discussion covers the interpretations of the protocols and makes recommendations for those protocols that have the best performance and at the same time are practical to perform. Read More

Otol Neurotol 2016 10;37(9):1457-61

*Drexel University College of Medicine†Department of Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.

Objective: To examine the relationship between white matter changes (WMCs) and abnormal balance test results on computerized dynamic posturography (CDP) and electronystagmography (ENG). Also, to compare the utility of CDP with ENG for this purpose.

Study Design: Retrospective case review. Read More

Acta Otolaryngol 2017 Jan 24;137(1):58-62. Epub 2016 Aug 24.

b Department of Otolaryngology , National Taiwan University Hospital , Taipei , Taiwan.

Conclusion: Like NAC ameliorates hearing loss from acoustic trauma in the inner ear, NAC may also rescue hearing loss from sudden deafness confined to the inner ear.

Objective: This study assesses the effect of N-acetyl-L-cysteine (NAC) as a single therapy for sudden deafness.

Methods: Thirty-five sudden deafness patients with neither systemic disorders nor central signs in electronystagmography were treated with NAC alone and assigned to Group A. Read More

Otol Neurotol 2016 09;37(8):1117-21

*Department of Otorhinolaryngology and Head and Neck Surgery, Federal University of São Paulo, São Paulo †Human Molecular Genetics Laboratory, State University of Campinas, Campinas, Brazil.

Objectives: Ménière's disease (MD) is a complex disease of unknown etiology characterized by a symptomatic tetrad of vertigo, hearing loss, tinnitus, and aural fullness. In addition to factors related to homeostasis of the inner ear, genetic factors have been implicated in its pathophysiology, including genes related to the transport of water and ionic composition maintenance of the endolymph, such as the aquaporin genes AQP2 and AQP3, and the potassium channel gene KCNE1. The aim of this study was to identify polymorphisms of these genes and determine their association with clinical characteristics of patients with MD. Read More

Front Neurol 2016 13;7:101. Epub 2016 Jul 13.

Neuro-otology Department, National Hospital for Neurology and Neurosurgery, London, England; Ear Institute, UCL, London, UK.

Introduction: Evidence is emerging for a significant clinical and neuroanatomical relationship between balance and anxiety. Research has suggested a potentially priming effect with anxiety symptoms predicting a worsening of balance function in patients with underlying balance dysfunction. We propose to show that a vestibular stimulus is responsible for an increase in state anxiety, and there is a relationship between increased state anxiety and worsening balance function. Read More

Vestn Otorinolaringol 2016 ;81(3):12-16

Russian University of People's Friendship, Moscow, Russia, 117198.

The authors consider the specific features of the vestibular function in the patients with sensorineural hearing loss of vascular genesis. The study included 60 patients at the age from 28 to 75 years presenting with sensorineural impairment of hearing of vascular genesis. All of them were examined with the use of the extended otoneurological method. Read More