14,840 results match your criteria Electroconvulsive Therapy


Better, Faster, Safer: Exploring Biomarkers of Response to Transform Electroconvulsive Therapy.

Biol Psychiatry 2019 Mar;85(6):439-440

National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.01.009DOI Listing

Pediatric anti-NMDA receptor encephalitis with catatonia: treatment with electroconvulsive therapy.

Pediatr Rheumatol Online J 2019 Feb 18;17(1). Epub 2019 Feb 18.

Section of Pediatric Rheumatology, Department of Pediatrics, University of Chicago Medical Center, 5841 S. Maryland Avenue, MC 5044, Chicago, 60637, IL, USA.

Background: Anti-NMDA receptor encephalitis, an autoimmune disease associated with antibodies against N-methyl-D-aspartate (NMDA) receptors, is being diagnosed more frequently, especially in children and young adults. Acute neurological and psychiatric manifestations are the common presenting symptoms. Diagnosing anti-NMDA receptor encephalitis is often challenging given the wide range of clinical presentation, and may be further complicated by its overlap of symptoms, brain MRI changes, and CSF findings with other entities affecting the brain. Read More

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http://dx.doi.org/10.1186/s12969-019-0310-0DOI Listing
February 2019

Electroconvulsive Therapy Modulates Resting-State EEG Oscillatory Pattern and Phase Synchronization in Nodes of the Default Mode Network in Patients With Depressive Disorder.

Front Hum Neurosci 2019 1;13. Epub 2019 Feb 1.

Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan.

: Electroconvulsive therapy (ECT) has antidepressant effects, but it also has possible cognitive side effects. The effects of ECT on neuronal oscillatory pattern and phase synchronization, and the relationship between clinical response or cognitive change and electroencephalogram (EEG) measurements remain elusive. : Individuals with unipolar depressive disorder receiving bilateral ECT were recruited. Read More

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http://dx.doi.org/10.3389/fnhum.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367251PMC
February 2019

Accelerated transcranial magnetic stimulation for the treatment of Patients with depression: A review.

Authors:
Fady Rachid

Asian J Psychiatr 2019 Feb 8;40:71-75. Epub 2019 Feb 8.

Private Practice, 7, place de la Fusterie, 1204, Geneva, Switzerland. Electronic address:

Major depressive disorder is a highly prevalent and profoundly disabling psychiatric disorder with significant morbidity and mortality and it is very often resistant to antidepressants, electroconvulsive therapy and psychotherapy. Therapeutic alternatives include repetitive transcranial magnetic stimulation which may be an effective choice for treatment-resistant depression but requires prolonged treatments for at least four to six weeks. Shorter exposure to this technique might be more advantageous for certain cases. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.02.003DOI Listing
February 2019

Psychobiological factors of resilience and depression in late life.

Transl Psychiatry 2019 Feb 14;9(1):88. Epub 2019 Feb 14.

Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA.

In contrast to traditional perspectives of resilience as a stable, trait-like characteristic, resilience is now recognized as a multidimentional, dynamic capacity influenced by life-long interactions between internal and environmental resources. We review psychosocial and neurobiological factors associated with resilience to late-life depression (LLD). Recent research has identified both psychosocial characteristics associated with elevated LLD risk (e. Read More

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http://www.nature.com/articles/s41398-019-0424-7
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http://dx.doi.org/10.1038/s41398-019-0424-7DOI Listing
February 2019
1 Read

Celebrating the 80th anniversary of electroconvulsive therapy.

Braz J Psychiatry 2019 Jan-Mar;41(1):7-8

Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, UTHealth, Houston, TX, USA.

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http://dx.doi.org/10.1590/1516-4446-2018-4102DOI Listing
February 2019
1.638 Impact Factor

Lowering the seizure threshold in electroconvulsive therapy using transcranial magnetic stimulation: A case report.

Brain Stimul 2019 Jan 24. Epub 2019 Jan 24.

Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czechia.

We demonstrate the feasibility of lowering the seizure threshold using a combined approach of electroconvulsive therapy and transcranial magnetic stimulation. High-frequency transcranial magnetic stimulation of the supplementary motor area shortly before each electroconvulsive treatment session resulted in a reduction of the seizure threshold by half in a male patient with a severe psychotic depressive episode of bipolar affective disorder. Read More

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http://dx.doi.org/10.1016/j.brs.2019.01.012DOI Listing
January 2019
1 Read

Electroconvulsive therapy in conjunction with concurrent radiation treatment for laryngeal cancer.

Psychooncology 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1002/pon.5022DOI Listing
February 2019
1 Read

[Neuronal effects and biomarkers of antidepressant treatments : Current review from the perspective of neuroimaging].

Nervenarzt 2019 Feb 7. Epub 2019 Feb 7.

Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Münster, Universität Münster, Albert-Schweitzer-Campus 1, Geb. A9, 48149, Münster, Deutschland.

Depression is one of the most frequent and disabling mental disorders worldwide and is accompanied by a severe impairment in the quality of life. There are numerous imaging studies showing differences in the volume of gray and white brain matter and function between patients suffering from depression and healthy controls. Neuroimaging studies show that pharmacotherapy and electroconvulsive therapy are accompanied by an increase of hippocampal gray matter volume while as a result of psychotherapy activity changes in the anterior cingulate cortex (ACC) have repeatedly been reported. Read More

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http://dx.doi.org/10.1007/s00115-019-0675-9DOI Listing
February 2019
1 Read

Prescribing practices of Indian psychiatrists in the treatment of bipolar disorder.

Aust N Z J Psychiatry 2019 Feb 7:4867419826718. Epub 2019 Feb 7.

6 Medical Affairs, GlaxoSmithKline Pharmaceuticals Ltd, Mumbai, India.

Objective:: The treatment of bipolar disorder is challenging because of its clinical complexity and availability of multiple treatment options, none of which are ideal mood stabilizers. This survey studies prescription practices of psychiatrists in India and their adherence to guidelines.

Method:: In total, 500 psychiatrists randomly selected from the Indian Psychiatric Society membership directory were administered a face-to-face 22-item questionnaire pertaining to the management of bipolar disorder. Read More

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http://dx.doi.org/10.1177/0004867419826718DOI Listing
February 2019
2 Reads
3.407 Impact Factor

Electroconvulsive Therapy After Flow Diversion Stenting of Intracranial Aneurysm.

J ECT 2019 Feb 1. Epub 2019 Feb 1.

Department of Surgery (Neurosurgery) Dalhousie University Halifax, Nova Scotia, Canada Department of Psychiatry Dalhousie University Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1097/YCT.0000000000000576DOI Listing
February 2019

Safety of Electroconvulsive Therapy in 2 Very Young Pediatric Patients With Catatonia Related to Anti-N-methyl-D-aspartate Receptor Encephalitis.

J ECT 2019 Feb 1. Epub 2019 Feb 1.

Department of Psychiatry University of Illinois at Chicago Chicago, Department of Psychiatry and Behavioral Neuroscience The University of Chicago Chicago, IL.

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http://dx.doi.org/10.1097/YCT.0000000000000575DOI Listing
February 2019
1 Read

How Much Do Benzodiazepines Matter for Electroconvulsive Therapy in Patients With Major Depression?

J ECT 2019 Feb 1. Epub 2019 Feb 1.

Background: Electroconvulsive therapy (ECT) is one of the most effective treatments for major depressive disorder (MDD), especially in cases of treatment-resistant MDD. Because of their pharmacological profiles, benzodiazepines (BZDs) are suspected to decrease the efficacy of ECT. This study investigated the effect of BZDs on ECT-induced clinical outcomes and ECT course parameters in patients with MDD. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000574DOI Listing
February 2019

Subarachnoid Hemorrhage in the Setting of Electroconvulsive Therapy in a Patient With an Unsecured Cerebral Aneurysm: A Case Report and Review of the Literature.

J ECT 2019 Feb 1. Epub 2019 Feb 1.

From the Department of Neurology, Johns Hopkins Hospital, Baltimore, MD.

Objectives: The aim of the study was to report a case of a patient who experienced a fatal aneurysmal subarachnoid hemorrhage during the course of electroconvulsive therapy (ECT).

Methods: This is a case report and review of the literature.

Results: Electroconvulsive therapy is widely viewed as a safe and effective treatment for major depressive disorder; however, there remains some uncertainty regarding the safety of ECT in patients with cerebral aneurysms. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000573DOI Listing
February 2019
1 Read

Electroconvulsive Therapy in Incapable Patients Refusing Treatment: Prevalence, Effectiveness, and Associated Factors.

J ECT 2019 Feb 1. Epub 2019 Feb 1.

Academy for Ethics in Medicine, Göttingen, Germany.

Objectives: Severe psychiatric disorders may be accompanied by life-threatening conditions, lack of insight, and treatment refusal. Involuntary treatment may be indicated in patients who lack capacity to consent and refuse treatment. In this context, there is a lack of systematic data regarding the use of electroconvulsive therapy (ECT) in Germany. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000572DOI Listing
February 2019
2 Reads

Fenfluramine, a serotonin-releasing drug, prevents seizure-induced respiratory arrest and is anticonvulsant in the DBA/1 mouse model of SUDEP.

Epilepsia 2019 Feb 4. Epub 2019 Feb 4.

Departments of Pharmacology and Neurology, Southern Illinois University School of Medicine, Springfield, Illinois.

Objective: Prevention of sudden unexpected death in epilepsy (SUDEP) is a critical goal for epilepsy therapy. The DBA/1 mouse model of SUDEP exhibits an elevated susceptibility to seizure-induced death in response to electroconvulsive shock, hyperthermia, convulsant drug, and acoustic stimulation. The serotonin hypothesis of SUDEP is based on findings that treatments which modify serotonergic function significantly alter susceptibility to seizure-induced sudden death in several epilepsy models, including DBA/1 mice. Read More

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http://dx.doi.org/10.1111/epi.14658DOI Listing
February 2019
2 Reads

Reduced serum and cerebrospinal fluid levels of autotaxin in major depressive disorder.

Int J Neuropsychopharmacol 2019 Feb 2. Epub 2019 Feb 2.

Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Background: The autotaxin (ATX)/lysophosphatidic acid (LPA) axis is involved in diverse biological processes including neurodevelopment, inflammation, and immunological functioning. The LPA1 receptor has been implicated in the pathophysiology of major depressive disorder (MDD) and in the mechanism of action of antidepressants. However, it is unclear whether central or peripheral ATX levels are altered in patients with MDD. Read More

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http://dx.doi.org/10.1093/ijnp/pyz005DOI Listing
February 2019

Repetitive transcranial magnetic stimulation for depression - Authors' reply.

Lancet 2019 02;393(10170):403-404

Department of Psychiatry and Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; MRI-Guided rTMS Clinic and Krembil Research Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1016/S0140-6736(18)32837-XDOI Listing
February 2019
6 Reads

Mixed States: Modelling and Management.

CNS Drugs 2019 Feb 2. Epub 2019 Feb 2.

Discipline of Psychiatry, Northern Clinical School, University of Sydney, Sydney, NSW, 2000, Australia.

Our current conceptualisation of mixed states, defined as co-occurring manic and depressive symptoms, is unlikely to advance our knowledge or inform clinical practice. Episodes of mixed states can no longer be coded in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), and the 'mixed features specifier' fails to capture the most common mixed state presentations. This reflects a lack of understanding of both the importance of mixed states and their underlying pathophysiology. Read More

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http://dx.doi.org/10.1007/s40263-019-00609-3DOI Listing
February 2019
1 Read

Geographical access to electroconvulsive therapy services in Texas.

J Affect Disord 2019 02 12;245:1135-1138. Epub 2018 Dec 12.

Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center McGovern Medical School, Houston, Tx, United States. Electronic address:

Aims: Electroconvulsive Therapy (ECT) is a well-established and effective treatment in mood disorders but the use of ECT in Texas is much lower than the general average among the United States. Our goal is to explore the geographical accessibility of Electroconvulsive Services in Texas.

Methods: 22 ECT Centers in Texas listed in State's 2016 annual ECT report were enrolled and georeferenced. Read More

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http://dx.doi.org/10.1016/j.jad.2018.12.013DOI Listing
February 2019
3.383 Impact Factor

Schizoaffective disorder: A review.

Ann Clin Psychiatry 2019 Feb;31(1):47-53

University of Iowa Carver College of Medicine, Iowa City, IA 52242. E-MAIL:

Background: Schizoaffective disorder (SAD) is a chronic, potentially disabling psychotic disorder common in clinical settings. SAD often has been used as a diagnosis for individuals having an admixture of mood and psychotic symptoms whose diagnosis is uncertain. Its hallmark is the presence of symptoms of a major mood episode (either a depressive or manic episode) concurrent with symptoms characteristic of schizophrenia, such as delusions, hallucinations, or disorganized speech. Read More

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February 2019
2 Reads

Clozapine augmentation strategies - a systematic meta-review of available evidence. Treatment options for clozapine resistance.

J Psychopharmacol 2019 Jan 30:269881118822171. Epub 2019 Jan 30.

1 Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Germany.

Background:: Treatment options for clozapine resistance are diverse whereas, in contrast, the evidence for augmentation or combination strategies is sparse.

Aims:: We aimed to extract levels of evidence from available data and extrapolate recommendations for clinical practice.

Methods:: We conducted a systematic literature search in the PubMed/MEDLINE database and in the Cochrane database. Read More

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http://dx.doi.org/10.1177/0269881118822171DOI Listing
January 2019

Attitudes Toward Electroconvulsive Therapy Among Involuntary and Voluntary Patients.

J ECT 2019 Jan 28. Epub 2019 Jan 28.

Objective: We aimed to examine attitudes toward electroconvulsive therapy (ECT) among involuntary patients, voluntary patients, and their relatives.

Methods: Patients experiencing a major depressive episode and receiving ECT and their relatives were recruited for the survey. Patients and their relatives answered the self-rating questionnaires with a 7-point Likert scale. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000571DOI Listing
January 2019

Changes in Pre- and Post-Electroconvulsive Therapy Serum Myostatin Levels in Patients with Treatment Resistant Depression.

Clin Psychopharmacol Neurosci 2019 Feb;17(1):74-79

Department of Psychiatry, Gülhane Faculty of Medicine, University of Health Sciences, Ankara, Turkey.

Objective: Myostatin is a growth factor which is investigated regarding musculoskeletal system. Albeit its effect on muscle mass is known, it is considered likely having other unknown effects as well, particularly on central nervous system. With this study, it is aimed to find out that what type of effect electroconvulsive therapy (ECT) does on myostatin in patients with treatment resistant depression. Read More

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http://dx.doi.org/10.9758/cpn.2019.17.1.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361038PMC
February 2019

Etomidate improves seizure adequacy during electroconvulsive therapy.

Psychiatry Res 2019 Jan 17;273:350-354. Epub 2019 Jan 17.

Research and Innovation area, Hospital General de Granollers, Granollers, Barcelona, Spain.

The purpose of this study was to assess whether switching propofol to etomidate during an electroconvulsive therapy course improves seizure quality in convulsion-resistant patients. A retrospective study of paired cases included thirty-three patients. Seizure variables for each agent were assessed. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.065DOI Listing
January 2019
2 Reads

A novel approach for assessing neuromodulation using phase-locked information measured with TMS-EEG.

Sci Rep 2019 Jan 23;9(1):428. Epub 2019 Jan 23.

Department of Intelligent Interaction Technology, Graduate School of Systems and Information Engineering, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8573, Japan.

Neuromodulation therapies such as electroconvulsive therapy (ECT) are used to treat several neuropsychiatric disorders, including major depressive disorder (MDD). Recent work has highlighted the use of combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) to evaluate the therapeutic effects of neuromodulation; particularly, the phase locking factor (PLF) and phase locking value (PLV) can reportedly assess neuromodulation-induced functional changes in cortical networks. To examine changes in TMS-induced PLV and PLF before and after ECT, and their relationship with depression severity in patients with MDD, TMS-EEG and the Montgomery-Åsberg Depression Rating Scale (MADRS; depression severity) were implemented before and after ECT in 10 patients with MDD. Read More

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http://dx.doi.org/10.1038/s41598-018-36317-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344580PMC
January 2019
3 Reads

Managing psychotic depression and diagnostic uncertainty in liaison psychiatry.

BMJ Case Rep 2019 Jan 20;12(1). Epub 2019 Jan 20.

Liaison Psychiatry, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

A middle-aged woman presented with a history of symptoms of depression with psychotic features severely affecting her physical health. Neuroimaging of her brain suggested pathological changes out of keeping with her age, leading to further investigations including genetic testing for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis was also considered as a differential diagnosis as an initial serum test for anti-NMDAR autoantibodies was positive. Read More

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http://dx.doi.org/10.1136/bcr-2018-227606DOI Listing
January 2019
1 Read

Variations in Hippocampal White Matter Diffusivity Differentiate Response to Electroconvulsive Therapy in Major Depression.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 Nov 14. Epub 2018 Nov 14.

Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California, Los Angeles, Los Angeles, California; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California. Electronic address:

Background: Electroconvulsive therapy (ECT) is an effective treatment for severe depression and is shown to increase hippocampal volume and modulate hippocampal functional connectivity. Whether variations in hippocampal structural connectivity occur with ECT and relate to clinical response is unknown.

Methods: Patients with major depression (n = 36, 20 women, age 41. Read More

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http://dx.doi.org/10.1016/j.bpsc.2018.11.003DOI Listing
November 2018
2 Reads

Electroconvulsive treatment prevents chronic restraint stress-induced atrophy of the hippocampal formation-A stereological study.

Brain Behav 2019 Feb 18;9(2):e01195. Epub 2019 Jan 18.

Research Laboratory for Stereology and Neuroscience, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.

Introduction: Electroconvulsive therapy (ECT) is one of the most efficient treatments of major depressive disorder (MDD), although the underlying neurobiology remains poorly understood. There is evidence that ECT and MDD exert opposing effects on the hippocampal formation with respect to volume and number of neurons. However, there has been a paucity of quantitative data in experimental models of ECT and MDD. Read More

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http://dx.doi.org/10.1002/brb3.1195DOI Listing
February 2019
1 Read

Tako-Tsubo Cardiomyopathy during a series of Electroconvulsive Therapy (ECT) applications: A case report, systematic literature research and discussion of specific risk factors.

Fortschr Neurol Psychiatr 2018 Nov 17;86(11):699-710. Epub 2019 Jan 17.

Universitätsklinikum Köln, Klinik und Poliklinik für Psychiatrie und Psychotherapie.

Background: Tako-Tsubo Cardiomyopathy (TTC) is an acute, reversible disease of the myocardium. It seems to be caused by an excess of epinephrine, norepinephrine and dopamine. Psychological or physiological stress is considered as a risk factor. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0653-7063
Publisher Site
http://dx.doi.org/10.1055/a-0653-7063DOI Listing
November 2018
5 Reads

[Cognitive deficits associated with electroconvulsive therapy for depression: moderating factors and neuropsychological tests].

Fortschr Neurol Psychiatr 2018 Nov 17;86(11):690-698. Epub 2019 Jan 17.

Klinik und Poliklinik für Psychiatrie und Psychotherapie Heinrich-Heine-Universität, Medizinische Fakultät, Düsseldorf.

Due to the efficacy of electroconvulsive therapy (ECT) in the guideline-based treatment of therapy-resistant depressive episodes and the clinical significance of cognitive impairments, it is necessary to optimize the management of potential side effects. As cognitive side effects of the treatment combined with impairments resulting from the depression may lead to a reduction in the ability to function in social contexts and reduce subjective wellbeing, comprehensive information about and monitoring of potential side effects is essential. In this review we present the clinical relevance and measurement of cognitive side effects that may occur during electroconvulsive therapy. Read More

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http://dx.doi.org/10.1055/a-0758-1387DOI Listing
November 2018
5 Reads

[Determinants of relapse after electroconvulsive therapy in depressed patients].

Fortschr Neurol Psychiatr 2018 Nov 17;86(11):711-717. Epub 2019 Jan 17.

UK Aachen, Klinik für Psychiatrie, Psychotherapie und Psychosomatik.

Background: Maintaining remission after successful acute treatment remains a challenge in the use of electroconvulsive therapy (ECT). For this purpose, the concept of gradually tapered continuation ECT (C-ECT) has been increasingly propagated. The present study is aimed at identifying factors that contribute to relapse after ECT in depressed patients. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0762-0624
Publisher Site
http://dx.doi.org/10.1055/a-0762-0624DOI Listing
November 2018
7 Reads

Effect of different charges of modified electroconvulsive seizure on the cognitive behavior in stressed rats: Effects of GluR1 phosphorylation and CaMKIIα activity.

Exp Ther Med 2019 Jan 28;17(1):748-758. Epub 2018 Nov 28.

Department of Anesthesiology, The Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei 445000, P.R. China.

Electroconvulsive therapy (ECT) is an efficient therapy for major depression and modern ECT requires anesthesia to enhance safety. However, the commonly used anesthetic, propofol, may weaken the treatment efficacy. A recent study confirmed that ketamine rapidly reduced the symptoms of depression in affected patients. Read More

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http://dx.doi.org/10.3892/etm.2018.7022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307485PMC
January 2019
3 Reads

Post-electrocution persistent manic-depressive syndrome: a unique diagnostic syndrome and a red flag against electroconvulsive therapy?

Authors:
S Nahdiya C Syukri

Med J Malaysia 2018 Dec;73(6):441-442

Hospital Teluk Intan, Department of Psychiatry, Perak, Malaysia.

Bipolar mood disorder is an established psychiatric disorder affecting 1% of the population and it is a highly disabling disease. As of today, its aetiology is still a confounding question. This case is interesting as the patient presented with a full-blown mania after suffering from electrical injury. Read More

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December 2018
1 Read

Neuromodulatory treatments for post-traumatic stress disorder (PTSD).

Prog Neuropsychopharmacol Biol Psychiatry 2019 Jan 11;92:148-160. Epub 2019 Jan 11.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA; VA RR&D Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence, RI, USA.

Electroconvulsive therapy has been used successfully in some individuals with posttraumatic stress disorder (PTSD) whose symptoms have not improved with other treatments. But there are only a few reports. Meanwhile, an array of new neuromodulation strategies, including repetitive transcranial magnetic stimulation, transcranial direct current stimulation, vagus nerve stimulation, trigeminal nerve stimulation, and deep brain stimulation have been developed and applied experimentally in the treatment of other psychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.01.004DOI Listing
January 2019
7 Reads

[Electroconvulsion therapy for persistent depression in the Netherlands; very low application rate].

Tijdschr Psychiatr 2019 ;61(1):16-21

Background: Of all depressive disorders, 20% has a persistent course. For persistent depressive patients, electroconvulsive therapy (ect) is recommended for this patient population, since it is the most potent treatment for depression. The Dutch depression guideline advises the use of ect for persistent depressive disorder at approximately 12 months after inadequate efficacy of psychotherapy and/or pharmacological treatment. Read More

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January 2019
1 Read

TrkB neurotrophin receptor at the core of antidepressant effects, but how?

Authors:
Tomi Rantamäki

Cell Tissue Res 2019 Jan 12. Epub 2019 Jan 12.

Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

The role of brain-derived neurotrophic factor (BDNF) and its receptor TrkB has been studied in the context of mood disorders and their treatments for a couple of decades. Pharmacologically diverse antidepressant drugs increase the synthesis of BDNF in the cortex (and some subcortical structures) and this effect accounts for their ability to facilitate neurotrophic processes eventually leading into heightened plasticity within the cortex. Induction of BDNF-TrkB signaling has also been associated with the mechanism of action of ketamine and more recently with some other anesthetics, even with ones not thought to possess antidepressant potential. Read More

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http://dx.doi.org/10.1007/s00441-018-02985-6DOI Listing
January 2019

The effect of electroconvulsive therapy on cerebral monoamine oxidase A expression in treatment-resistant depression investigated using positron emission tomography.

Brain Stimul 2019 Jan 2. Epub 2019 Jan 2.

Neuroimaging Labs (NIL) PET, MRI, EEG, TMS and Chemical Lab, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria. Electronic address:

Background: Electroconvulsive therapy (ECT) constitutes one of the most effective antidepressant treatment strategies in major depression (MDD). Despite its common use and uncontested efficacy, its mechanism of action is still insufficiently understood. Previously, we showed that ECT is accompanied by a global decrease of serotonin-1A receptors in MDD; however, further studies to investigate the involvement of the serotonergic system in the mechanism of action of ECT are warranted. Read More

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http://dx.doi.org/10.1016/j.brs.2018.12.976DOI Listing
January 2019
2 Reads

An Overview of Reviews on the Safety of Electroconvulsive Therapy Administered During Pregnancy.

J Psychiatr Pract 2019 Jan;25(1):2-6

COSHAL, JONES, COVERDALE, AND LIVINGSTON: Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX.

Objective: To inform obstetricians and psychiatrists about the safety of electroconvulsive therapy (ECT) administration during pregnancy and to reconcile conflicting recommendations concerning this treatment.

Methods: A systematically conducted overview was undertaken on the safety of ECT during pregnancy. The Cochrane Library, MEDLINE/PubMed, PsycINFO, and Ovid were independently searched by 2 of the authors from January 2015 to March 2017 using the following search terms: electroconvulsive therapy, ECT, and electroshock combined with pregnancy and reviews. Read More

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http://dx.doi.org/10.1097/PRA.0000000000000359DOI Listing
January 2019

Choosing the Primary Outcome in Electroconvulsive Therapy Trials and the Art of Asking When, Besides What.

J ECT 2019 Jan 9. Epub 2019 Jan 9.

From the Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India.

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http://dx.doi.org/10.1097/YCT.0000000000000567DOI Listing
January 2019

An Adult With Obsessive-Compulsive-Related Disorders and Tics Post-Carbon Monoxide Poisoning Who Responded Ultimately to Electroconvulsive Therapy.

Authors:
Ahmed Naguy

J ECT 2019 Jan 9. Epub 2019 Jan 9.

Child/Adolescent Psychiatrist Al-Manara CAP Centre Kuwait Centre for Mental Health Kuwait City, Kuwait

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http://dx.doi.org/10.1097/YCT.0000000000000564DOI Listing
January 2019
1 Read
1.387 Impact Factor

Electroconvulsive Therapy-Related Tardive Seizure.

J ECT 2019 Jan 9. Epub 2019 Jan 9.

Department of Psychiatry HCMC-Regions Psychiatry Training Program St Paul, MN Department of Psychiatry University of Minnesota and Regions Hospital Minneapolis-St Paul, MN Department of Psychiatry University of Louisville School of Medicine Louisville, KY.

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http://dx.doi.org/10.1097/YCT.0000000000000565DOI Listing
January 2019

Electroconvulsive therapy: 80 years old and still going strong.

World J Psychiatry 2019 Jan 4;9(1):1-6. Epub 2019 Jan 4.

University of Notre Dame, Fremantle, WA 6009, Australia.

Electroconvulsive therapy (ECT), which is among the oldest and most controversial treatments in the field of psychiatry, has its 80 birthday this year. In this brief historical overview, the discovery of the therapeutic effects of convulsive therapy by Laszló Meduna, and the circumstances that motivated Ugo Cerletti and Lucio Bini to use electricity as a means of seizure induction are described. Meduna's original theory about the antagonism between epilepsy and schizophrenia has been replaced by hypotheses on the mechanism of action of ECT. Read More

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http://dx.doi.org/10.5498/wjp.v9.i1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323557PMC
January 2019

Neuroimaging Biomarkers at Baseline Predict Electroconvulsive Therapy Overall Clinical Response in Depression: A Systematic Review.

J ECT 2019 Jan 8. Epub 2019 Jan 8.

Service de Psychiatrie et Psychologie Médicale, CHU Toulouse, ToNIC Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France.

Objective: Major depressive disorder is a frequent and disabling disease and can be treated with antidepressant drugs. When faced with severe or resistant major depressive disorder, however, psychiatrists may resort to electroconvulsive therapy (ECT). Although very effective, the response falls short of 100%. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000570DOI Listing
January 2019
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A Retrospective Study of Cognitive Improvement Following Electroconvulsive Therapy in Schizophrenia Inpatients.

J ECT 2019 Jan 8. Epub 2019 Jan 8.

Department of General Psychiatry, Institute of Mental Health, Singapore.

Objectives: Findings on the cognitive effect of electroconvulsive therapy (ECT) in individuals with schizophrenia have brought mixed results, with few recent studies beginning to report cognitive improvements after treatment. Cognitive change in inpatients with schizophrenia who were referred for an acute course of ECT was examined in the current study. Furthermore, the study aimed to determine the profile of patients who experience cognitive improvement and the potential use of a brief cognitive battery to detect this positive cognitive change, if any. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000569DOI Listing
January 2019
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Porphyria Misdiagnosed as Schizophrenia Nonresponsive to Electroconvulsive Therapy.

J ECT 2019 Jan 8. Epub 2019 Jan 8.

Adult Psychiatry C Service, Unit of ECT, Hospital de Magalhães Lemos, Oporto, Portugal,

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http://dx.doi.org/10.1097/YCT.0000000000000563DOI Listing
January 2019

Acute-Onset Atrial Fibrillation Following an Electrically Induced Generalized Convulsion in a Patient Treated With Clozapine and Electroconvulsive Therapy.

J ECT 2019 Jan 8. Epub 2019 Jan 8.

Department of Psychiatry and Mental Health Centro Hospitalar de Lisboa OcidentalLisbon, Portugal Department of Psychiatry and Mental Health Centro Hospitalar de Lisboa Ocidental Champalimaud Research & Clinical Centre Champalimaud Centre for the Unknown. NOVA Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa Lisbon, Portugal

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http://dx.doi.org/10.1097/YCT.0000000000000558DOI Listing
January 2019
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Should we stop using electroconvulsive therapy?

BMJ 2019 Jan 9;364:k5233. Epub 2019 Jan 9.

Department of Psychiatry, Trinity College Dublin, St Patrick's University Hospital, Dublin, Ireland

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http://dx.doi.org/10.1136/bmj.k5233DOI Listing
January 2019

Acute and long-term effects of electroconvulsive therapy on human dentate gyrus.

Neuropsychopharmacology 2019 Jan 8. Epub 2019 Jan 8.

Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, although the underlying mechanisms remain unclear. Animal studies have consistently shown that electroconvulsive stimulation induces neuroplastic changes in the dentate gyrus. To date, few studies have investigated the effect of ECT on human hippocampal subfields. Read More

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http://www.nature.com/articles/s41386-019-0312-0
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http://dx.doi.org/10.1038/s41386-019-0312-0DOI Listing
January 2019
4 Reads
7.048 Impact Factor