15,487 results match your criteria Electroconvulsive Therapy


Electroconvulsive Therapy Pulse Amplitude and Clinical Outcomes.

Am J Geriatr Psychiatry 2020 Jun 17. Epub 2020 Jun 17.

Division of Psychology, Department of Psychiatry (SMM), UT Southwestern Medical Center, Dallas, TX; Division of Brain Stimulation and Neurophysiology (SMM), Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC.

Introduction: Electroconvulsive therapy (ECT) pulse amplitude, which determines the induced electric field magnitude in the brain, is currently set at 800-900 milliamperes (mA) on modern ECT devices without any clinical or scientific rationale. The present study assessed differences in depression and cognitive outcomes for three different pulse amplitudes during an acute ECT series. We hypothesized that the lower amplitudes would maintain the antidepressant efficacy of the standard treatment and reduce the risk of neurocognitive impairment. Read More

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http://dx.doi.org/10.1016/j.jagp.2020.06.008DOI Listing

The innate immune system and neurogenesis as modulating mechanisms of electroconvulsive therapy in pre-clinical studies.

J Psychopharmacol 2020 Jul 10:269881120936538. Epub 2020 Jul 10.

Department of Psychological Medicine, King's College London, London, UK.

Background: Electroconvulsive therapy (ECT) is a powerful and fast-acting anti-depressant strategy, often used in treatment-resistant patients. In turn, patients with treatment-resistant depression often present an increased inflammatory response. The impact of ECT on several pathophysiological mechanisms of depression has been investigated, with a focus which has largely been on cellular and synaptic plasticity. Read More

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http://dx.doi.org/10.1177/0269881120936538DOI Listing

Pentadic Cartography: Mapping Postpartum Psychosis Narratives.

Qual Health Res 2020 Jul 10:1049732320938357. Epub 2020 Jul 10.

University of Connecticut, Storrs, Connecticut, USA.

Writing online narratives of postpartum psychosis allows both self-analysis and catharsis and can also be viewed as a type of sociopolitical expression. Eight narratives posted on the Action on Postpartum Psychosis website were analyzed using Burke's narrative analysis. This method focuses on a pentad of key elements of story: scene, act, purpose, agent, and agency. Read More

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http://dx.doi.org/10.1177/1049732320938357DOI Listing

Depression, mitochondrial bioenergetics, and electroconvulsive therapy: a new approach towards personalized medicine in psychiatric treatment - a short review and current perspective.

Transl Psychiatry 2020 Jul 9;10(1):226. Epub 2020 Jul 9.

Clinic for Psychiatry and Psychotherapy III, Ulm University Clinic, Ulm, Baden-Wuerttemberg, Germany.

Major depressive disorder (MDD) is a globally occurring phenomenon and developed into a severe socio-economic challenge. Despite decades of research, the underlying pathophysiological processes of MDD remain incompletely resolved. Like other mental disorders, MDD is hypothesized to mainly affect the central nervous system (CNS). Read More

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http://dx.doi.org/10.1038/s41398-020-00901-7DOI Listing

[Importance of electroconvulsive therapy (ECT) in forensic psychiatry].

Nervenarzt 2020 Jul 8. Epub 2020 Jul 8.

Klinik für Psychiatrie und Psychotherapie, Universitätsmedizin Göttingen, Von-Siebold-Straße 5, 37075, Göttingen, Deutschland.

Background And Objective: Electroconvulsive therapy (ECT) is recommended in guidelines for the treatment of severe affective and psychotic disorders that also can be found in patients in forensic psychiatric commitment; however, there are no systematically collected data concerning the use of ECT in forensic psychiatry. The aim of this study was to investigate the current state and estimated need for ECT in forensic psychiatry in Germany.

Material And Methods: A questionnaire was designed consisting of questions about the current practice and estimated need for ECT in this population. Read More

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http://dx.doi.org/10.1007/s00115-020-00947-4DOI Listing

DNA Methylation of the t-PA Gene Differs Between Various Immune Cell Subtypes Isolated From Depressed Patients Receiving Electroconvulsive Therapy.

Front Psychiatry 2020 19;11:571. Epub 2020 Jun 19.

Center for Systems Neuroscience, Hannover Graduate School for Veterinary Pathobiology, Neuroinfectiology, and Translational Medicine (HGNI), Hannover, Germany.

Background: Major depressive disorder (MDD) represents a tremendous health threat to the world's population. Electroconvulsive therapy (ECT) is the most effective treatment option for refractory MDD patients. Ample evidence suggests brain-derived neurotrophic factor (BDNF) to play a crucial role in ECT's mode of action. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319092PMC

Electroconvulsive Therapy and Triaging during Reduced Access & the COVID-19 Pandemic: A Personal Perspective.

Authors:
Michael L Demas

J ECT 2020 Jul 1. Epub 2020 Jul 1.

Associate Clinical Professor of Psychiatry, University of Alberta.

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http://dx.doi.org/10.1097/YCT.0000000000000713DOI Listing

Psychotic depression in hospitalized patients: Longitudinal outcomes of psychotic vs. nonpsychotic depression among inpatients: The role of depressive symptoms on clinical severity.

J Psychiatr Res 2020 Jun 2;129:73-79. Epub 2020 Jun 2.

Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil; Innovations and Interventions for Quality of Life Research Group, Brazil; Clinical Research Center of Hospital de Clínicas de Porto Alegre, Brazil; Experimental Research Center of Hospital de Clínicas de Porto Alegre, Brazil.

Even though psychotic depression is related to worse outcomes than nonpsychotic depression, there is increasing evidence that this greater severity is not solely explained by the depressive symptoms. We evaluated the socio-demographic and clinical characteristics, as well as the differences in clinical outcomes of psychiatric hospitalization between psychotic and non-psychotic depression. Two-hundred-eighty-eight depressive inpatients were assessed within 72 h after hospitalization and 24 h before discharge. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2020.06.002DOI Listing

Patient-level Characteristics and Inequitable Access to Inpatient Electroconvulsive Therapy for Depression: A Population-based Cross-sectional Study: Caractéristiques au niveau du patient et accès inéquitable à la thérapie électroconvulsive pour patients hospitalisés.

Can J Psychiatry 2020 Jul 2:706743720935647. Epub 2020 Jul 2.

Department of Psychiatry, University of Toronto, Ontario, Canada.

Objective: A variety of patient characteristics drive the use of electroconvulsive therapy (ECT) in depression. However, the extent to which each characteristic influences the receipt of ECT, and whether they are appropriate, is unknown. The aim of this study is to identify patient-level characteristics associated with receiving inpatient ECT for depression. Read More

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http://dx.doi.org/10.1177/0706743720935647DOI Listing

Frequency and Duration of Course of ECT Sessions: An Appraisal of Recent Evidence.

Indian J Psychol Med 2020 May-Jun;42(3):207-218. Epub 2020 Apr 25.

Consultant Psychiatrist, Bradgate Mental Health Unit, Leicester, England, UK.

Aims And Method: This paper aims to review the recent literature regarding factors influencing the frequency and number of sessions during a course of electroconvulsive therapy (ECT) for different psychiatric disorders. We systematically reviewed English-language papers of clinical trials of ECT published since the year 2000 in terms of frequency and number of sessions of ECT.

Results: None of the 30 studies meeting our inclusion criteria were specifically designed to study frequency or number of sessions of ECT. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_410_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320735PMC

Habenula deep brain stimulation for intractable schizophrenia: a pilot study.

Neurosurg Focus 2020 Jul;49(1):E9

1Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine.

Schizophrenia is a psychiatric disorder associated with significant morbidity and mortality. Although antipsychotic medications and electroconvulsive therapy can be used to manage the clinical symptoms of schizophrenia, a substantial portion (10%-30%) of patients do not clinically respond to these treatments or cannot tolerate the side effects. Recently, deep brain stimulation (DBS) has emerged as a promising safe and effective therapeutic intervention for various psychiatric disorders. Read More

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http://dx.doi.org/10.3171/2020.4.FOCUS20174DOI Listing
July 2020
2.105 Impact Factor

[Statistical versus clinical equivalence; the effectiveness of non-invasive neurostimulation in depression].

Authors:
S M van Belkum

Ned Tijdschr Geneeskd 2020 Jun 11;164. Epub 2020 Jun 11.

Rijksuniversiteit Groningen, UMCG, afd. Psychiatrie, Groningen.

There is increasing interest in the use of non-invasive neurostimulation in the treatment of depressive disorder. A recent meta-analysis compared different forms of neurostimulation, and concluded that the effectiveness of different forms of this therapy, for example repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS), was similar to electroconvulsive therapy (ECT). In this comment we discuss these different techniques; we also stress that an unfair comparison has been made between the different forms of neurostimulation. Read More

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Treatment-Resistant Depression With Catatonia Presenting as a Feature of Creutzfeldt-Jakob's Disease.

Cureus 2020 May 26;12(5):e8300. Epub 2020 May 26.

Internal Medicine, Coliseum Medical Centers, Macon, USA.

A high-functioning middle-aged successful businessman developed a rapid decline in his cognitive, behavioral, and motor abilities within one year. He was initially diagnosed with dementia by a neurologist and was then diagnosed with pseudo-dementia secondary to major depressive disorder with catatonia by a psychiatrist who initiated treatment with Ativan. He was referred to our psychiatric facility for an evaluation to undergo electroconvulsive therapy (ECT) as a potential treatment for medically refractory depression complicated with catatonia and pseudo-dementia. Read More

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http://dx.doi.org/10.7759/cureus.8300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317138PMC

rTMS and tDCS for the treatment of catatonia: A systematic review.

Schizophr Res 2020 Jun 26. Epub 2020 Jun 26.

Department of Psychiatry and Psychotherapy, University Hospital Munich, Nußbaumstraße 7, 80336 München, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics of the University Augsburg, Bezirkskrankenhaus Augsburg, University of Augsburg, Medical Faculty, Augsburg, Germany.

Background: Catatonia is a potentially life threatening syndrome in various psychiatric disorders. As first line treatment, benzodiazepines and electroconvulsive therapy (ECT) are recommended. In some cases, benzodiazepines are ineffective and ECT is not available or contraindicated. Read More

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http://dx.doi.org/10.1016/j.schres.2020.05.028DOI Listing

Effects of ketamine in electroconvulsive therapy for major depressive disorder: meta-analysis of randomised controlled trials.

Gen Psychiatr 2020 16;33(3):e100117. Epub 2020 Jun 16.

Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: The use of ketamine in electroconvulsive therapy (ECT) has been examined in the treatment of major depressive disorder (MDD); however, there has been no systematic review and meta-analysis of related randomised controlled trials (RCTs).

Aim: To examine the efficacy and safety of ketamine augmentation of ECT in MDD treatment.

Methods: Two reviewers searched Chinese (China National Knowledge Infrastructure and Wanfang) and English (PubMed, PsycINFO, Embase and Cochrane Library) databases from their inception to 23 July 2019. Read More

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http://dx.doi.org/10.1136/gpsych-2019-100117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299006PMC

Prescribing for moderate or severe unipolar depression in patients under the long-term care of UK adult mental health services.

Ther Adv Psychopharmacol 2020 15;10:2045125320930492. Epub 2020 Jun 15.

Division of Psychiatry, Imperial College London, London, UK.

Background: A quality improvement programme addressing prescribing practice for depression was initiated by the Prescribing Observatory for Mental Health.

Methods: A baseline clinical audit against evidence-based practice standards was conducted in UK adult mental health services.

Results: A total of 55 mental health services submitted data for 2082 patients, under the care of a community psychiatric team (CMHT) for at least a year, with a diagnosis of moderate or severe unipolar depression, 54% of whom had a comorbid psychiatric diagnosis. Read More

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http://dx.doi.org/10.1177/2045125320930492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297128PMC

When should we image our patients? Appropriate use of imaging in inpatient psychiatry.

Australas Psychiatry 2020 Jun 25:1039856220934313. Epub 2020 Jun 25.

Monash University, Australia.

Objective: Injudicious use of medical imaging may be associated with harm to patients and increased downstream healthcare costs. Guidance on the use of imaging in common psychiatric inpatient scenarios is inconsistent or absent. This paper explores three common clinical scenarios facing adult psychiatrists and provides guidance about the appropriate use of imaging. Read More

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http://dx.doi.org/10.1177/1039856220934313DOI Listing

The benefits and costs of changing treatment technique in electroconvulsive therapy due to insufficient improvement of a major depressive episode.

Brain Stimul 2020 Jun 22;13(5):1284-1295. Epub 2020 Jun 22.

Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, Augusta, GA, USA.

Background: Electroconvulsive therapy (ECT) technique is often changed after insufficient improvement, yet there has been little research on switching strategies.

Objective: To document clinical outcome in ECT nonresponders who were received a second course using high dose, brief pulse, bifrontotemporal (HD BP BL) ECT, and compare relapse rates and cognitive effects relative to patients who received only one ECT course and as a function of the type of ECT first received.

Methods: Patients were classified as receiving Weak, Strong, or HD BP BL ECT during three randomized trials at Columbia University. Read More

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http://dx.doi.org/10.1016/j.brs.2020.06.016DOI Listing

Lack of antidepressant effects of burst-suppressing isoflurane anesthesia in adult male Wistar outbred rats subjected to chronic mild stress.

PLoS One 2020 24;15(6):e0235046. Epub 2020 Jun 24.

Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Laboratory of Neurotherapeutics, Drug Research Program, University of Helsinki, Helsinki, Finland.

Post-ictal emergence of slow wave EEG (electroencephalogram) activity and burst-suppression has been associated with the therapeutic effects of the electroconvulsive therapy (ECT), indicating that mere "cerebral silence" may elicit antidepressant actions. Indeed, brief exposures to burst-suppressing anesthesia has been reported to elicit antidepressant effects in a subset of patients, and produce behavioral and molecular alterations, such as increased expression of brain-derived neurotrophic factor (BDNF), connected with antidepressant responses in rodents. Here, we have further tested the cerebral silence hypothesis by determining whether repeated exposures to isoflurane anesthesia reduce depressive-like symptoms or influence BDNF expression in male Wistar outbred rats (Crl:WI(Han)) subjected to chronic mild stress (CMS), a model which is responsive to repeated electroconvulsive shocks (ECS, a model of ECT). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235046PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313995PMC

Electroconvulsive therapy practice during the COVID-19 pandemic.

Clinics (Sao Paulo) 2020 06 22;75:e2056. Epub 2020 Jun 22.

Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

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http://dx.doi.org/10.6061/clinics/2020/e2056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297524PMC

Rapid efficacy of aripiprazole in the treatment of catatonic depression/catatonia with consideration of the drug's unique receptor profile: a case report.

Fortschr Neurol Psychiatr 2020 Jun 23. Epub 2020 Jun 23.

Krankenhaus für Psychiatrie Psychotherapie und Psychosomatische Medizin Schloss Werneck.

Catatonia is a widespread problem in psychiatric hospitals as approximately 10% of patients present with catatonic symptoms upon admission. Catatonia carries the risk of severe, even fatal complications. The first line treatment is usually electroconvulsive therapy (ECT) or benzodiazepines, but ECT may not be readily available and benzodiazepines may not always be effective. Read More

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http://dx.doi.org/10.1055/a-1183-3887DOI Listing

Troponin time courses after electroconvulsive therapy and physical stress may differ from incidents causing structural myocardial deficits.

Brain Stimul 2020 Jun 19;13(5):1282-1283. Epub 2020 Jun 19.

Department of Psychiatry, Psychotherapy and Psychosomatic, Medical Faculty, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1016/j.brs.2020.06.014DOI Listing

Images in Clinical Electroconvulsive Therapy: Portable 1-Channel Electroencephalogram Device as Adjunctive Seizure Monitoring.

J ECT 2020 Jun 12. Epub 2020 Jun 12.

ECT Service, Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil.

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http://dx.doi.org/10.1097/YCT.0000000000000698DOI Listing

Resource Document for Electroconvulsive Therapy in Adult Correctional Settings.

J ECT 2020 Jun 12. Epub 2020 Jun 12.

From the University of North Carolina School of Medicine, Chapel Hill, NC.

Electroconvulsive therapy (ECT) has been used for decades for the treatment of mental illness. Despite its proven efficacy, ECT is rarely offered to individuals with psychiatric disorders who are incarcerated in jails and prisons. There are currently 2. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000694DOI Listing

Efficacious Use of Electroconvulsive Therapy in the Setting of Previous Retinal Detachment.

J ECT 2020 Jun 12. Epub 2020 Jun 12.

Weill Cornell Medical College New York, NY Weill Cornell Medicine Department of Psychiatry New York-Presbyterian Westchester Behavioral Health Center White Plains, NY

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http://dx.doi.org/10.1097/YCT.0000000000000691DOI Listing
June 2020
1.387 Impact Factor

Recurrence After Stopping Maintenance Electroconvulsive Therapy: A Retrospective Case Series.

J ECT 2020 Jun 12. Epub 2020 Jun 12.

From the Addictology and Liaison Psychiatry Department, University Hospital of Nantes.

Objectives: Relapses and recurrence remain the greatest risks posed by patients with severe mood disorders after discontinuation of electroconvulsive therapy (ECT). To date, despite a wide range of literature on ECT, little is known about the rate of recurrence of depression after maintenance ECT (mECT) discontinuation specifically. This study sought to address this lacuna, confronting literature data to the results of a retrospective case study. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000693DOI Listing

Modified Anesthesia Protocol for Electroconvulsive Therapy Permits Reduction in Aerosol-Generating Bag-Mask Ventilation during the COVID-19 Pandemic.

Psychother Psychosom 2020 Jun 18:1-6. Epub 2020 Jun 18.

Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.

Introduction: Electroconvulsive therapy (ECT) is a critical procedure in psychiatric treatment, but as typically delivered involves the use of bag-mask ventilation (BMV), which during the COVID-19 pandemic exposes patients and treatment staff to potentially infectious aerosols.

Objective: To demonstrate the utility of a modified anesthesia protocol for ECT utilizing preoxygenation by facemask and withholding the use of BMV for only those patients who desaturate during the apneic period.

Methods: This chart review study analyzes patients who were treated with ECT using both the traditional and modified anesthesia protocols. Read More

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http://dx.doi.org/10.1159/000509113DOI Listing

ECT non-remitters: prognosis and treatment after 12 unilateral electroconvulsive therapy sessions for major depression.

J Affect Disord 2020 Jul 29;272:501-507. Epub 2020 Apr 29.

Parnassia Psychiatric Institute, The Hague, The Netherlands. Electronic address:

Background: Depressive disorder causes significant suffering in patients and caregivers worldwide. Electroconvulsive therapy (ECT) is a highly effective antidepressant treatment, but little is known about the prognosis and treatment of patients who do not achieve remission with ECT. We investigated prognosis and treatment of patients with major depression who did not achieve remission after 12 unilateral electroconvulsive therapy sessions. Read More

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http://dx.doi.org/10.1016/j.jad.2020.03.134DOI Listing

Psychotic depressive subtype and white mater hyperintensities do not predict cognitive side effects in ECT: A systematic review of pretreatment predictors.

J Affect Disord 2020 Jul 4;272:340-347. Epub 2020 May 4.

Parnassia PG, The Hague, The Netherlands; Department of Psychology, Brain & Cognition, University of Amsterdam, Amsterdam, The Netherlands.; Department of Medical Psychology, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Background: Most studies regarding cognitive side-effects following ECT for treating depression report transient forms of cognitive disturbances. However, a growing number of studies also report considerable differences among individual patients.

Objective: The aim of this systematic review was to identify pretreatment patient characteristics for predicting the risk of developing cognitive side-effects following ECT. Read More

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http://dx.doi.org/10.1016/j.jad.2020.03.181DOI Listing

The effect of ketamine versus thiopental sodium on hemodynamic profile and seizure duration during electroconvulsive therapy in patients with major depressive disorder: A randomized cross-over clinical trial.

Med J Islam Repub Iran 2020 25;34:11. Epub 2020 Feb 25.

Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran.

Electroconvulsive therapy (ECT) is an effective treatment in major depressive disorder (MDD). Earlier studies suggest that ketamine has antidepressive effects and prolongs seizure duration in favor of therapeutic efficacy of ECT. A great concern with the use of ketamine is its possible adverse hemodynamic effects during ECT. Read More

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http://dx.doi.org/10.34171/mjiri.34.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293804PMC
February 2020

[The introduction of antipsychotics in the neurological psychiatric hospital of the University of Leipzig and their effects on other forms of therapy, the length of stay and transferrals].

Nervenarzt 2020 Jun 15. Epub 2020 Jun 15.

Forschungsstelle für die Geschichte der Psychiatrie, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Medizinische Fakultät der Universität Leipzig, Semmelweisstr. 10, 04103, Leipzig, Deutschland.

Aim: The impacts of the introduction of antipsychotics on psychiatric care in a clinic were investigated for the first time, specifically in the Neurological and Psychiatric Clinic of the University of Leipzig from 1946 to 1965.

Research Questions: When and which antipsychotics were first used, to what extent and how did this affect the use of traditional forms of therapy?

Material And Methods: According to psychopathological criteria, 306 cases were selected from the database of patient records from the hospital archive and systematically reviewed with respect to the research question.

Results: The use of antipsychotics began in 1953 and subsequently with increasing frequency and duration. Read More

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http://dx.doi.org/10.1007/s00115-020-00931-yDOI Listing

ECT augmentation of antipsychotics in severely ill schizophrenia: a naturalistic, observational study.

Int J Psychiatry Clin Pract 2020 Jun 15:1-6. Epub 2020 Jun 15.

Psychology Department, Halic University, Istanbul, Turkey.

There is positive evidence to support the role of electroconvulsive therapy (ECT) in the treatment of schizophrenia; however, it is unclear to what extent this growing evidence reflects the actual situation in clinical practice. The aim of this study was to explore the efficacy of ECT augmentation to antipsychotics in individuals with schizophrenia in a naturalistic-observational environment. Eighty-one patients diagnosed with schizophrenia, hospitalised due to acute psychotic exacerbation were included in the study. Read More

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http://dx.doi.org/10.1080/13651501.2020.1777313DOI Listing

Definitive treatment options for pediatric catatonia should include electroconvulsive therapy.

Eur Child Adolesc Psychiatry 2020 Jun 13. Epub 2020 Jun 13.

Department of Child and Adolescent Psychiatry, University Hospital Motol, Prague, Czech Republic.

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http://dx.doi.org/10.1007/s00787-020-01576-7DOI Listing

Neuroanatomical Features That Predict Response to Electroconvulsive Therapy Combined With Antipsychotics in Schizophrenia: A Magnetic Resonance Imaging Study Using Radiomics Strategy.

Front Psychiatry 2020 21;11:456. Epub 2020 May 21.

Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Objective: Neuroimaging-based brain signatures may be informative in identifying patients with psychosis who will respond to antipsychotics. However, signatures that inform the electroconvulsive therapy (ECT) health care professional about the response likelihood remain unclear in psychosis with radiomics strategy. This study investigated whether brain structure-based signature in the prediction of ECT response in a sample of schizophrenia patients using radiomics approach. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253706PMC

An Observational Retrospective Study Investigating Changes in Seizure Adequacy Parameters of Electroconvulsive Therapy and Their Relationships to Clinical Outcome in Schizophrenia and Schizoaffective Disorder.

Clin EEG Neurosci 2020 Jun 11:1550059420932076. Epub 2020 Jun 11.

Department of Psychiatry, Erenköy Mental Health and Neurology Training & Research Hospital, Istanbul, Turkey.

The aim of the current study was to investigate a possible relationship between electroconvulsive therapy (ECT) seizure adequacy parameters and clinical outcome as well as differences between ECT responders and nonresponders in terms of ECT seizure parameters in patients diagnosed with schizophrenia and schizoaffective disorder. First and last ECT records data, sociodemographic variables, and baseline and post ECT Positive and Negative Syndrome Scale scores were obtained. Maximum sustained power was higher in last ECT in favor of responders while peak heart rate was higher in ECT nonresponders than responders in first ECT. Read More

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http://dx.doi.org/10.1177/1550059420932076DOI Listing

Electroconvulsive Therapy in Super Refractory Status Epilepticus: Case Series with a Defined Protocol.

Int J Environ Res Public Health 2020 Jun 5;17(11). Epub 2020 Jun 5.

SjællandsUniversitets Hospital, 4000 Roskilde, Denmark.

Super-refractory status epilepticus (SRSE) represents a neurological emergency that is characterized by a lack of response to the third line of antiepileptic treatment, including intravenous general anesthetics. It is a medical challenge with high morbidity and mortality. Electroconvulsive therapy (ECT) has been recommended as a nonpharmacologic option of treatment after other alternatives are unsuccessful. Read More

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http://dx.doi.org/10.3390/ijerph17114023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312395PMC

Prolactin changes during electroconvulsive therapy: A systematic review and meta-analysis.

J Psychiatr Res 2020 May 29;128:25-32. Epub 2020 May 29.

The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, NY, USA; Hofstra Northwell School of Medicine, Hempstead, New York and the Feinstein Institute for Medical Research, Manhasset, NY, USA.

Background: Early studies reported a prolactin surge during electroconvulsive therapy (ECT). The aim of this study is to review and meta-analyze data on ECT-related prolactin changes.

Method: A systematic review and meta-analysis was conducted for trials investigating prolactin changes in ECT-treated patients using standard mean differences (SMD, 95% confidence intervals). Read More

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http://dx.doi.org/10.1016/j.jpsychires.2020.05.024DOI Listing

Electroconvulsive therapy for severe depression, psychosis and chorea in a patient with Huntington's disease: case report and review of the literature.

BJPsych Bull 2020 Jun 9:1-8. Epub 2020 Jun 9.

South West Yorkshire Partnership NHS Foundation Trust, Wakefield, UK.

Aims And Method: The psychiatric manifestations of Huntington's disease are myriad and difficult to control. The use of electroconvulsive therapy (ECT) is not commonly considered for this condition. We describe a patient with severe depression, psychomotor retardation, delusions and weight loss who responded to ECT with good control of her symptoms. Read More

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http://dx.doi.org/10.1192/bjb.2020.51DOI Listing

Effectiveness and Safety of Intravenous Ketamine for Severely Depressed Patients Unable to Receive Electroconvulsive Therapy Due to Medical Risks.

Prim Care Companion CNS Disord 2020 Jun 4;22(3). Epub 2020 Jun 4.

Behavioral Health Services, Queen's Medical Center, Honolulu, Hawaii, USA.

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http://dx.doi.org/10.4088/PCC.19l02535DOI Listing

Malignant Catatonia as the Presenting Manifestation of Systemic Lupus Erythematosus.

Bull Hosp Jt Dis (2013) 2020 Jun;78(2):146-152

Malignant catatonia represents a potentially life-threatening presentation of catatonia that typically includes fever, autonomic instability, and cardiovascular collapse. Failure to respond to benzodiazepines, particularly with an increase in catatonic signs, should raise suspicion for the presence of malignant catatonia. Here, we report the first case of malignant catatonia as the initial manifestation of systemic lupus erythematosus (SLE) presenting in a 15-year-old girl who developed progressive catatonia that was resistant to immunosuppressive therapy with pulse corticosteroids, intravenous immunoglobulin (IVIg), and cyclophosphamide and required electroconvulsive therapy for clinical improvement. Read More

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Traditional Atriopulmonary Connection Fontan with Excellent Outcome for 32 Years.

Thorac Cardiovasc Surg Rep 2020 Jan 3;9(1):e18-e20. Epub 2020 Jun 3.

Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, Shenyang, Peoples' Republic of China.

Although the traditional right atrial-pulmonary artery (RA-PA) Fontan has been replaced by the total cavopulmonary connection, some RA-PA Fontan patients still have good outcome. We report a 37-year-old male who underwent traditional Fontan 32 years ago with the diagnosis of L-transposition of great arteries, subvalvular pulmonary stenosis and cardiac dextroversion. Among the recent CTA, electroconvulsive therapy, catheterization and angiography, pulsatile PA, uniform pulmonary blood, normal PA pressure and resistance were observed in this patient. Read More

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http://dx.doi.org/10.1055/s-0040-1708528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269721PMC
January 2020

[Recommendations for a gradual and controlled resumption of electroconvulsive therapy in France during the period of lifting of the containment and of the COVID-19 pandemic linked to SARS-CoV-2].

Encephale 2020 Jun 4;46(3S):S119-S122. Epub 2020 Jun 4.

French Society for Biological Psychiatry and Neuropsychopharmacology, STEP Section (Stimulation transcrânienne en psychiatrie), Saint-Germain-en-Laye, France; CHU Nantes, Department of Addictology and Psychiatry, Nantes, France; Inserm-U1246 SPHERE University of Nantes and University of Tours, Nantes, France.

The COVID-19 pandemic has had major consequences for the organization of care. In France and around the world, centers practicing electroconvulsive therapy (ECT) have seen their activity decrease, or even stop for many reasons. In this context, maintaining or resuming this essential therapeutic activity for many patients suffering from psychiatric disorders requires material, human and logistical adaptations that should be supervised. Read More

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http://dx.doi.org/10.1016/j.encep.2020.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271849PMC

[Innovative therapeutic approaches in psychiatry : neuromodulation. For whom, why and how ?]

Rev Med Liege 2020 May;75(5-6):426-431

Service de Neurochirurgie, CHU Liège, Belgique.

Recent technological advances have seen the resumption or the advent of new approaches in the field of psychiatry such as electroconvulsive therapy, repeated transcranial magnetic stimulation, transcranial direct current electrical stimulation or even deep brain stimulation. These new approaches offer a window into the understanding of the neurobiological mechanisms linked to mental illnesses. This review summarizes current knowledges in the field and the future directions for the treatment of depression or obsessive-compulsive disorder. Read More

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Association of treatment facets, severity of manic symptoms, psychomotor disturbances and psychotic features with response to electroconvulsive therapy in bipolar depression.

World J Biol Psychiatry 2020 Jun 3:1-9. Epub 2020 Jun 3.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Clinically useful predictors of response to electroconvulsive therapy (ECT) are warranted, especially in the case of bipolar depression. The aim of this study was to explore the associations between response and its known and putative correlates. Six hundred seventy bipolar depressive patients treated with ECT were included in the study. Read More

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http://dx.doi.org/10.1080/15622975.2020.1770860DOI Listing

A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol.

BMC Psychiatry 2020 Jun 2;20(1):268. Epub 2020 Jun 2.

The Royal's Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, ON, K1Z 7K4, Canada.

Background: Recent evidence underscores the utility of rapid-acting antidepressant interventions, such as ketamine, in alleviating symptoms of major depressive episodes (MDE). However, to date, there have been limited head-to-head comparisons of intravenous (IV) ketamine infusions with other antidepressant treatment strategies in large randomized trials. This study protocol describes an ongoing multi-centre, prospective, randomized, crossover, non-inferiority trial comparing acute treatment of individuals meeting diagnostic criteria for a major depressive episode (MDE) with ketamine and electroconvulsive therapy (ECT) on efficacy, speed of therapeutic effects, side effects, and health care resource utilization. Read More

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http://dx.doi.org/10.1186/s12888-020-02672-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265624PMC

General Anesthesia Recommendations for Electroconvulsive Therapy During the Coronavirus Disease 2019 Pandemic.

J ECT 2020 Jun 12. Epub 2020 Jun 12.

Department of Anesthesiology, Weill Cornell Medicine/New York-Presbyterian.

Background: Coronavirus disease 2019 is an infectious viral disease first identified in December 2019 in Wuhan, China, and very rapidly spread globally resulting in a pandemic. Common symptoms include fever, cough, and shortness of breath. Although the majority of patients recover, there are still a significant number of patients who progress to respiratory failure, multiorgan failure, and death. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299092PMC

Inflammation and depression treatment response to electroconvulsive therapy: Sex-specific role of interleukin-8.

Brain Behav Immun 2020 May 29. Epub 2020 May 29.

Cousins Center for Psychoneuroimmunology, United States; Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, United States.

Females suffer from depression at twice the rate of males and have differential neural and emotional responses to inflammation. However, sex-specific evaluation of relationships between inflammation and response to depression treatments are lacking. Some data suggest that interleukin(IL)-8 predicts treatment response to antidepressants and has a relationship with depressive symptom severity. Read More

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http://dx.doi.org/10.1016/j.bbi.2020.05.069DOI Listing

Naturalistic follow-up in bipolar patients after successful electroconvulsive therapy.

J Affect Disord 2020 Jun 11;271:152-159. Epub 2020 Apr 11.

Psychiatry Unit 2, Azienda Ospedaliero-Universitaria Pisana, Italy; Department of Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address:

Background: Electroconvulsive therapy (ECT) is an effective treatment for acute depression, mania and mixed states. We evaluated the long-term outcome of patients with bipolar depression or mixed state, responsive to ECT.

Methods: this observational follow-up study was conducted in 70 patients with Bipolar Disorder: 36 patients met DSM-IV-TR criteria for a major depressive episode (MDE) and 34 for a mixed episode (MXE). Read More

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http://dx.doi.org/10.1016/j.jad.2020.03.079DOI Listing