14,923 results match your criteria Electroconvulsive Therapy


First known case of catatonia due to cyclosporine A-related neurotoxicity in a pediatric patient with steroid-resistant nephrotic syndrome.

BMC Psychiatry 2019 Apr 24;19(1):123. Epub 2019 Apr 24.

Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.

Background: Catatonia is a neuropsychiatric syndrome characterized by diverse psychomotor abnormalities, including motor dysregulation and behavioral and affective disturbances. Once thought to occur primarily in the context of schizophrenia, recent data suggest most cases of catatonia develop in individuals with depressive or bipolar disorders. Moreover, catatonia may ensue in general medical and neurological conditions, as well as due to a variety of pharmaceuticals, drugs of abuse, and toxic agents. Read More

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http://dx.doi.org/10.1186/s12888-019-2107-6DOI Listing

Influence of electroconvulsive therapy on white matter structure in a diffusion tensor imaging study.

Psychol Med 2019 Apr 23:1-8. Epub 2019 Apr 23.

Department of Psychiatry,University of Muenster,Germany.

Background: Electroconvulsive therapy (ECT) is a fast-acting intervention for major depressive disorder. Previous studies indicated neurotrophic effects following ECT that might contribute to changes in white matter brain structure. We investigated the influence of ECT in a non-randomized prospective study focusing on white matter changes over time. Read More

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http://dx.doi.org/10.1017/S0033291719000758DOI Listing

Electroconvulsive therapy "corrects" the neural architecture of visuospatial memory: Implications for typical cognitive-affective functioning.

Neuroimage Clin 2019 Apr 5;23:101816. Epub 2019 Apr 5.

Rotman Research Institute, University of Toronto, Canada. Electronic address:

Although electroconvulsive therapy (ECT) is a widely used and effective treatment for refractory depression, the neural underpinnings of its therapeutic effects remain poorly understood. To address this issue, here, we focused on a core cognitive deficit associated with depression, which tends to be reliably ameliorated through ECT, specifically, the ability to learn visuospatial information. Thus, we pursued three goals. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468194PMC
April 2019
1 Read

Caregivers' Attitude and Perspective on Coercion and Restraint Practices on Psychiatric Inpatients from South India.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):261-266

Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.

Background: Coercion and restraint practices in psychiatric care are common phenomena and often controversial and debatable ethical issue. Caregivers' attitude and perspective on coercion and restraint practices on psychiatric inpatients have received relatively less research attention till date.

Aims: Caregivers' attitude and perspective on coercion and restraint practices on psychiatric inpatients. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_302_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454949PMC

Acute and subsequent continuation electroconvulsive therapy elevates serum BDNF levels in patients with major depression.

Brain Stimul 2019 Feb 26. Epub 2019 Feb 26.

Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria. Electronic address:

Introduction: The induction of brain-derived neurotrophic factor (BDNF) release and subsequent restoration of neuroplastic homeostasis may underlie the effects of electroconvulsive therapy (ECT).

Objectives: We aimed to assess serum and plasma BDNF levels during the course of acute ECT, as well as before and after subsequent continuation ECT, in patients with depression.

Methods: We included 24 patients with major depressive disorder (mean age ± SD: 54. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.015DOI Listing
February 2019
1 Read

BDNF Genotype and Baseline Serum Levels in Relation to Electroconvulsive Therapy Effectiveness in Treatment-Resistant Depressed Patients.

J ECT 2019 Feb 26. Epub 2019 Feb 26.

Psychiatric Hospital "Villa Santa Chiara," Verona.

Objectives: Electroconvulsive therapy (ECT) represents one of the most effective therapies for treatment-resistant depression (TRD). The brain-derived neurotrophic factor (BDNF) is a neurotrophin implicated in major depressive disorder and in the effects of different therapeutic approaches, including ECT. Both BDNF peripheral levels and Val66Met polymorphism have been suggested as biomarkers of treatment effectiveness. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000583DOI Listing
February 2019
3 Reads

The anaesthetic-ECT time interval with thiopentone-Impact on seizure quality.

J Affect Disord 2019 Apr 9;252:135-140. Epub 2019 Apr 9.

School of Psychiatry, University of New South Wales (UNSW), Hospital Road, Randwick, New South Wales 2031, Australia; Black Dog Institute, Hospital Road, Randwick, New South Wales2031, Australia; The Wesley Hospital, 7 Blake St, Kogarah, New South Wales 2217, Australia; St. George Hospital, Gray St, Kogarah, New South Wales 2217, Australia.

Background: The time between anaesthetic induction and ECT stimulus administration has been hypothesised to significantly impact ictal EEG quality. In this study, our aim was to examine the effect of the time interval between anaesthetic induction and the ECT stimulus for ictal seizure quality in ECT sessions utilising thiopentone anaesthesia.

Methods: 413 EEG traces from 42 patients, collected retrospectively, were manually rated using a quantitative-qualitative structured rating scale (indices including seizure amplitude, regularity, post-ictal suppression and general seizure quality). Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.027DOI Listing
April 2019
1 Read

Is stigma preventing knowledge translation and utilization of electroconvulsive therapy for depression?

Acta Psychiatr Scand 2019 Apr 13. Epub 2019 Apr 13.

Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.

We welcome the recent publication of Dr. Munkholm's insightful letter to the editor outlining his concerns of our meta-analysis comparing the effectiveness of electroconvulsive therapy (ECT) in unipolar major depression (MDD) and bipolar major depression (BD). Despite its established efficacy and safety profile, the use of ECT remains a highly controversial and stigmatized practice - even among psychiatrists. Read More

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http://dx.doi.org/10.1111/acps.13035DOI Listing
April 2019
1 Read

The kynurenine pathway: a finger in every pie.

Authors:
Jonathan Savitz

Mol Psychiatry 2019 Apr 12. Epub 2019 Apr 12.

Laureate Institute for Brain Research, Tulsa, OK, USA.

The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially increased during an immune response, the KP is a key regulator of the immune system. Perhaps more importantly in the context of psychiatry, many kynurenines are neuroactive, modulating neuroplasticity and/or exerting neurotoxic effects in part through their effects on NMDA receptor signaling and glutamatergic neurotransmission. Read More

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http://www.nature.com/articles/s41380-019-0414-4
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http://dx.doi.org/10.1038/s41380-019-0414-4DOI Listing
April 2019
14 Reads

Association between the novel seizure quality index for the outcome prediction in electroconvulsive therapy and brain-derived neurotrophic factor serum levels.

Neurosci Lett 2019 Apr 9;704:164-168. Epub 2019 Apr 9.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

The novel Seizure Quality Index (SQI) could predict the risk of non-response and non-remission as early as after the second electroconvulsive therapy (ECT) session based the extent of several ictal parameters of the seizure in patients with depression. The association between those indices with the peripheral serum levels of brain-derived neurotrophic factor (BDNF) was evaluated in this study. It was proposed that seizure quality reflected by the SQI will be positively correlated with the levels of serum BDNF after ECT in patients with depression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940193025
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http://dx.doi.org/10.1016/j.neulet.2019.04.023DOI Listing
April 2019
7 Reads

Right Unilateral Ultrabrief Electroconvulsive Therapy in the Maintenance Treatment of Schizophrenia.

J ECT 2019 Apr 8. Epub 2019 Apr 8.

Adult Mental Health Rehabilitation Unit NorthWestern Mental Health Melbourne Health Western Hospital Sunshine St Albans, Victoria Australia Melbourne Neuropsychiatry Centre Department of Psychiatry Western Centre for Health and Education University of Melbourne and Melbourne Health St Albans, Victoria Australia Adult Mental Health Rehabilitation Unit NorthWestern Mental Health Melbourne Health Western Hospital Sunshine St Albans, Victoria Australia Department of psychiatry The University of Melbourne Melbourne, Australia Adult Mental Health Rehabilitation Unit NorthWestern Mental Health Melbourne Health Western Hospital Sunshine St Albans, Victoria Australia Melbourne Neuropsychiatry Centre Department of Psychiatry Western Centre for Health and Education University of Melbourne and Melbourne Health St Albans, Victoria Australia Florey Institute for Neuroscience and Mental Health Parkville Victoria Australia.

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http://dx.doi.org/10.1097/YCT.0000000000000594DOI Listing

Electroconvulsive Therapy in Recurrent Oligodendroglioma After Resection.

J ECT 2019 Apr 8. Epub 2019 Apr 8.

Geisel School of Medicine at Dartmouth College Hanover, NH National Center for Posttraumatic Stress Disorder US Department of Veteran Affairs White River Junction, VT Department of Surgery Dartmouth-Hitchcock Medical Center Lebanon, NH Department of Psychiatry Dartmouth-Hitchcock Medical Center Lebanon, NH Geisel School of Medicine at Dartmouth College Hanover, NH Department of Psychiatry Dartmouth-Hitchcock Medical Center Lebanon, NH

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http://dx.doi.org/10.1097/YCT.0000000000000593DOI Listing
April 2019
1 Read

Continuation Electroconvulsive Therapy for Patients With Clozapine-Resistant Schizophrenia: A Pilot Study.

J ECT 2019 Apr 9. Epub 2019 Apr 9.

From the Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, Glen Oaks; and The Feinstein Institute for Medical Research, Manhasset, NY.

Objectives: The risk of relapse after a successful acute course of treatment is a clinical challenge in electroconvulsive therapy (ECT) practice, particularly in patients with a history of marked resistance to previous treatments. Research suggests that a gradual decrease of ECT or its long-term continuation might be the best strategy. Notwithstanding, current studies do not address the role of continuation ECT in the truly refractory cases, that is, the clozapine-resistant patients. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000588DOI Listing

Oral Protection in Electroconvulsive Therapy: Modified Technique Using 2 Bite Blocks.

J ECT 2019 Apr 9. Epub 2019 Apr 9.

New York Community Hospital, Brooklyn, NY.

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http://dx.doi.org/10.1097/YCT.0000000000000585DOI Listing

Royal Australian and New Zealand College of Psychiatrists professional practice guidelines for the administration of electroconvulsive therapy.

Aust N Z J Psychiatry 2019 Apr 10:4867419839139. Epub 2019 Apr 10.

10 School of Psychiatry, UNSW Sydney, Sydney, NSW, Australia.

Objectives: To provide guidance for the optimal administration of electroconvulsive therapy, in particular maintaining the high efficacy of electroconvulsive therapy while minimising cognitive side-effects, based on scientific evidence and supplemented by expert clinical consensus.

Methods: Articles and information were sourced from existing guidelines and the published literature. Information was revised and discussed by members of the working group of the Royal Australian and New Zealand College of Psychiatrists' Section for Electroconvulsive Therapy and Neurostimulation, and findings were then formulated into consensus-based recommendations and guidance. Read More

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http://dx.doi.org/10.1177/0004867419839139DOI Listing

Brain Stimulation in Obsessive-Compulsive Disorder (OCD): A Systematic Review.

Curr Neuropharmacol 2019 04 9. Epub 2019 Apr 9.

Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University; "Sant'Andrea" University Hospital, Rome. Italy.

Background: Obsessive-compulsive disorder (OCD) is highly prevalent, severe, chronic, and disabling. There is need for alternative strategies for treatment-resistant OCD.

Objective: This review aims to assess the effect of brain stimulation techniques in OCD. Read More

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http://dx.doi.org/10.2174/1570159X17666190409142555DOI Listing
April 2019
1 Read

Network neurobiology of electroconvulsive therapy in patients with depression.

Psychiatry Res Neuroimaging 2019 May 20;287:31-40. Epub 2019 Mar 20.

Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore 560029, India; Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore 560029, India. Electronic address:

Graph theory, a popular analytic tool for resting state fMRI (rsfMRI) has provided important insights in the neurobiology of depression. We aimed to analyze the changes in the network measures of segregation and integration associated with the administration of ECT in patients with depression and to correlate with both clinical response and cognitive deficits. Changes in normalised clustering coefficient (γ), path length (λ) and small-world (σ) index were explored in 17 patients with depressive episode before 1st and after 6th brief-pulse bifrontal ECT (BFECT) sessions. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.03.008DOI Listing
May 2019
3 Reads

Maintenance electroconvulsive therapy in schizophrenia.

Psychiatr Danub 2019 Mar;31(1):62-68

Psychiatric Hospital, Havlickuv Brod, Czech Republic.

Background: The aim of our retrospective naturalistic observational study was to describe the use of maintenance electroconvulsive therapy (M-ECT) in chronic pharmacoresistant schizophrenia.

Subjects And Methods: We delineated 19 cases of chronic pharmacoresistant schizophrenia (females N=12) recently treated with maintenance electroconvulsive therapy at the Havlickuv Brod Psychiatric Hospital in the Czech Republic. Demographic, clinical and treatment variables were recorded. Read More

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http://dx.doi.org/10.24869/psyd.2019.62DOI Listing
March 2019
4 Reads

"To suit the occasion, I wore my schizophrenic fancy dress" - the life of Janet Frame.

Australas Psychiatry 2019 Apr 4:1039856219839489. Epub 2019 Apr 4.

Professor, Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, and; Ramsay Health Care (SA) Mental Health Services, Adelaide, SA, and; Northern Adelaide Local Health Network, Adelaide, SA, Australia.

Objective:: Janet Frame (1924-2004) was one of New Zealand's most celebrated authors. Much of her work stems from her experiences as a psychiatric patient. She was hospitalised for about eight years with a diagnosis of schizophrenia. Read More

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http://journals.sagepub.com/doi/10.1177/1039856219839489
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http://dx.doi.org/10.1177/1039856219839489DOI Listing
April 2019
4 Reads

Prognosis and improved outcomes in major depression: a review.

Transl Psychiatry 2019 Apr 3;9(1):127. Epub 2019 Apr 3.

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Treatment outcomes for major depressive disorder (MDD) need to be improved. Presently, no clinically relevant tools have been established for stratifying subgroups or predicting outcomes. This literature review sought to investigate factors closely linked to outcome and summarize existing and novel strategies for improvement. Read More

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http://dx.doi.org/10.1038/s41398-019-0460-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447556PMC
April 2019
6 Reads

Effectiveness of Kangaroo Care for a Patient with Postpartum Depression and Comorbid Mother-Infant Bonding Disorder.

Case Rep Psychiatry 2019 25;2019:9157214. Epub 2019 Feb 25.

Department of Neuropsychiatry, Toho University School of Medicine, 6-11-1 Omori-nishi, Ota-ku, Tokyo 143-8541, Japan.

The presently reported patient was a 37-year-old married primipara with peripartum depression comorbid with bonding disorder. Care anxiety and a lack of affection towards her baby first appeared at around the time of delivery, and the patient developed major depression at one month after the birth of her healthy baby. At first, standard treatment for major depression including the use of antidepressants, electroconvulsive therapy, and supportive psychotherapy were provided. Read More

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http://dx.doi.org/10.1155/2019/9157214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413388PMC
February 2019

Decreased Abundance after Electroconvulsive Therapy in the Gut Microbiota of a Patient with Schizophrenia.

Case Rep Psychiatry 2019 25;2019:4576842. Epub 2019 Feb 25.

Department of Psychiatry, Shimane University of Medicine, 89-1 Enyacho, Izumo 6938501, Japan.

Relationships between gut microbiota and various disease pathogeneses have been investigated, but those between the pathogeneses of mental illnesses, including schizophrenia, and gut microbiota have only recently attracted attention. We observed a change in the gut microbiota of a patient with schizophrenia after administering electroconvulsive therapy (ECT). A 59-year-old woman was diagnosed with schizophrenia at 17 years of age and has been taking antipsychotic drugs since the diagnosis. Read More

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http://dx.doi.org/10.1155/2019/4576842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413405PMC
February 2019
1 Read

Seizures Causing Simultaneous Bilateral Neck of Femur Fractures.

Case Rep Orthop 2019 27;2019:4570578. Epub 2019 Feb 27.

HOD Orthopaedics Northdale Hospital, Pietermaritzburg, South Africa.

Neck of femur fractures are a ubiquitous injury seen by orthopaedic surgeons. In the elderly, these fractures usually occur after a low energy fall, and are invariably unilateral injuries. Bilateral neck of femur fractures have been reported in patients with metabolic bone disease, after electroconvulsive therapy, and in association with stress fractures. Read More

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http://dx.doi.org/10.1155/2019/4570578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415288PMC
February 2019
3 Reads

Peripapillary retinal nerve fiber layer and ganglion cell complex degeneration in Egyptian patients with bipolar disorder.

Eye (Lond) 2019 Mar 29. Epub 2019 Mar 29.

Psychiatry Department, Faculty of Medicine, Cairo University, Giza, Egypt.

Purpose: To determine if changes in OCT parameters including peripapillary RNFL thickness and GCC thickness in Egyptian patients with bipolar disorder exist, and to correlate them with disease severity and clinical characteristics.

Methods: A case-control study conducted on 40 patients with bipolar disorder were compared to 40 matched healthy controls. Both patients and controls were subjected to ophthalmic examination including: BCVA, slit-lamp examination, fundus examination, and OCT imaging. Read More

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http://dx.doi.org/10.1038/s41433-019-0403-5DOI Listing
March 2019
1 Read

Electroconvulsive therapy response in late-life depression unaffected by age-related brain changes.

J Affect Disord 2019 Mar 20;251:114-120. Epub 2019 Mar 20.

KU Leuven, University Psychiatric Center KU Leuven, Department of Old Age Psychiatry, Herestraat 49, 3000 Leuven / Leuvensesteenweg 517, 3070 Kortenberg, Belgium.

Background: Gray matter volume decrease, white matter vascular pathology and amyloid accumulation are age-related brain changes that have been related to the pathogenesis of late life depression (LLD). Furthermore, lower hippocampal volume and more white matter hyperintensities (WMH) may contribute to poor response to electroconvulsive therapy (ECT) in severely depressed older adults. We hypothesized that the accumulation of age-related brain changes negatively affects outcome following ECT in LLD. Read More

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http://dx.doi.org/10.1016/j.jad.2019.03.055DOI Listing

Acute electroconvulsive therapy in the elderly with schizophrenia and schizoaffective disorder: a literature review.

Australas Psychiatry 2019 Mar 28:1039856219839470. Epub 2019 Mar 28.

Senior staff specialist psychogeriatrician; Sydney Local Health District, Concord Centre for Mental Health, Concord, NSW, Australia.

Objectives:: This study reviewed the evidence regarding the efficacy of acute electroconvulsive therapy for primary psychotic conditions in the elderly.

Methods:: A literature search was performed using the Medline, Embase and Cochrane databases.

Results:: Acute electroconvulsive therapy resulted in an improvement of psychotic symptoms in almost all elderly patients, a large proportion of whom had treatment-resistant conditions. Read More

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http://dx.doi.org/10.1177/1039856219839470DOI Listing
March 2019
4 Reads

Comparative efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults: systematic review and network meta-analysis.

BMJ 2019 03 27;364:l1079. Epub 2019 Mar 27.

South London and Maudsley Foundation NHS Trust, London, UK.

Objective: To estimate the comparative clinical efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults.

Design: Systematic review with pairwise and network meta-analysis.

Data Sources: Electronic search of Embase, PubMed/Medline, and PsycINFO up to 8 May 2018, supplemented by manual searches of bibliographies of several reviews (published between 2009 and 2018) and included trials. Read More

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http://dx.doi.org/10.1136/bmj.l1079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435996PMC
March 2019
6 Reads

Rates and Patient Characteristics of Electroconvulsive Therapy in China and Comparisons With the United States.

J ECT 2019 Mar 25. Epub 2019 Mar 25.

Department of Psychiatry, Yale School of Medicine, New Haven, CT.

Objective: Recent studies have expressed concern about the infrequent and declining use of electroconvulsive therapy (ECT) in the United States. However, it is not known whether the US experience reflects changing global practice or one that varies between countries. This observational study examined use of ECT in the largest psychiatric hospital in China's third largest city over a 4-year period, 2014 to 2017. Read More

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http://Insights.ovid.com/crossref?an=00124509-900000000-9915
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http://dx.doi.org/10.1097/YCT.0000000000000589DOI Listing
March 2019
4 Reads

Electroconvulsive Therapy Practice in the Kingdom of Denmark: A Nationwide Register- and Questionnaire-Based Study.

J ECT 2019 Mar 25. Epub 2019 Mar 25.

Department of Affective Disorders, Aarhus University Hospital, Aarhus.

Objectives: The aim of this study was to survey and describe the contemporary practice of electroconvulsive therapy (ECT) in the Kingdom of Denmark (Denmark, Greenland, and the Faroe Islands).

Methods: Data regarding number of ECTs and number of patients with different diagnoses treated with ECT were retrieved from the Danish National Patient Registry. In addition, a 45-item questionnaire was sent to all psychiatric departments practicing ECT in Denmark (n = 26), Greenland (n = 1), and the Faroe Islands (n = 1). Read More

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http://dx.doi.org/10.1097/YCT.0000000000000586DOI Listing

Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression.

Sci Rep 2019 Mar 25;9(1):5071. Epub 2019 Mar 25.

Division of Experimental Therapeutics, Department of Psychiatry, New York State Psychiatric Institute/Columbia University Medical Center, New York, NY, USA.

There is increasing focus on use of resting-state functional connectivity (RSFC) analyses to subtype depression and to predict treatment response. To date, identification of RSFC patterns associated with response to electroconvulsive therapy (ECT) remain limited, and focused on interactions between dorsal prefrontal and regions of the limbic or default-mode networks. Deficits in visual processing are reported in depression, however, RSFC with or within the visual network have not been explored in recent models of depression. Read More

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http://dx.doi.org/10.1038/s41598-019-41175-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433903PMC
March 2019
3 Reads

Electroconvulsive Therapy for Anticholinergic and Benzodiazepine Nonresponsive Tardive Oculogyric Crisis: A Case Report.

Am J Ther 2019 Mar 7. Epub 2019 Mar 7.

Department of Psychiatry, Beitou Branch, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.

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http://dx.doi.org/10.1097/MJT.0000000000000971DOI Listing
March 2019
4 Reads

The Impact of Whole Brain Global Functional Connectivity Density Following MECT in Major Depression: A Follow-Up Study.

Front Psychiatry 2019 1;10. Epub 2019 Mar 1.

Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

To explore the alteration of global functional connectivity density (gFCD) in depressive patients after modified electroconvulsive therapy (MECT) and analyze the relationship between gFCD and clinical outcome. Thirty-seven subjects were evaluated based on the diagnostic criteria of the International Classification of Diseases-10 (ICD-10), consisting of a depressive group (24 patients after follow-ups) and a healthy control group with 13 normal individuals. All participants received Hamilton Depression Scale (HAMD) scores and resting-state functional magnetic resonance imaging scans. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413803PMC

Electroconvulsive therapy for trichotillomania in a bipolar patient.

Bull Menninger Clin 2019 ;83(1):97-104

Brain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences (MICCN) and School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.

A recent review on the use of electroconvulsive therapy (ECT) in obsessive-compulsive-related disorders (OCRDs) identified reports of trichotillomania (TTM) in only three patients, but it did not describe the specific effect of ECT on hair-pulling behaviors. The authors present a case report of Mrs. A, a 77-year-old widowed housewife with a lifelong history of episodic TTM and bipolar disorder who was effectively treated with ECT. Read More

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http://dx.doi.org/10.1521/bumc.2019.83.1.97DOI Listing
January 2019
1 Read

Electroconvulsive therapy for treatment-resistant schizophrenia.

Cochrane Database Syst Rev 2019 03 19;3:CD011847. Epub 2019 Mar 19.

General Adult Psychiatry, Nottinghamshire Healthcare NHS Trust, Bassetlaw Hospital, Worksop, South Yorkshire, UK, S81 0BD.

Background: Electroconvulsive therapy (ECT) involves the induction of a seizure by the administration of an electrical stimulus via electrodes usually placed bilaterally on the scalp and was introduced as a treatment for schizophrenia in 1938. However, ECT is a controversial treatment with concerns about long-term side effects such a memory loss. Therefore, it is important to determine its clinical efficacy and safety for people with schizophrenia who are not responding to their treatment. Read More

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http://dx.doi.org/10.1002/14651858.CD011847.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424225PMC
March 2019
1 Read

Electroconvulsive stimulation differentially affects [C]MDL100,907 binding to cortical and subcortical 5HT receptors in porcine brain.

J Psychopharmacol 2019 Mar 19:269881119836212. Epub 2019 Mar 19.

7 Department of Medicine/Neurology, University of British Columbia, Vancouver, BC, Canada.

Background:: Electroconvulsive therapy is an effective therapy of depression. We hypothesized that the beneficial effects are mediated partly by decreased serotonin receptor availability in the cortex.

Aims:: We used positron emission tomography with the serotonin 5HT receptor radioligand [C]MDL100,907 to determine serotonin receptor availability in response to electroconvulsive stimulation (ECS). Read More

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http://dx.doi.org/10.1177/0269881119836212DOI Listing
March 2019
2 Reads

Electroconvulsive therapy against the natural will: Some concerns.

Eur Psychiatry 2019 05 15;58:87-88. Epub 2019 Mar 15.

Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Mecicine, RWTH Aachen, Germany.

In recent years, the scientific interest in "Electroconvulsive therapy (ECT) against the patient's natural" will has grown. Several publications have reported mostly positive outcomes in cases, where ECT has been implemented against the patient's natural will. The author's findings primarily indicate the effectiveness of ECT in non-consenting patients, which confirms earlier findings. Read More

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http://dx.doi.org/10.1016/j.eurpsy.2019.03.002DOI Listing

Effect of Donepezil on Cognitive Deficits Associated With Electroconvulsive Therapy: A Randomized Triple-blind Clinical Trial.

Clin Neuropharmacol 2019 Mar/Apr;42(2):27-31

Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Objectives: Despite the effectiveness of electroconvulsive therapy (ECT) in a wide range of psychiatric disorders, the role of memory-enhancing agents in post-ECT cognitive disturbances has remained controversial. In this study, we aimed to assess the effect of donepezil on improving the cognitive performance of patients undergoing ECT.

Methods: In a psychiatry hospital, patients who were admitted for ECT underwent a triple-blind randomized controlled trial. Read More

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http://dx.doi.org/10.1097/WNF.0000000000000323DOI Listing
March 2019
1 Read

Vagus Nerve Stimulation as a Treatment for Catatonia: A Hypothesis.

Authors:
David Zilles

Front Psychiatry 2019 27;10:86. Epub 2019 Feb 27.

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.

Catatonia is a syndrome comprising psychomotor, behavioral, and autonomous symptoms which may occur in the context of severe schizophrenic, affective, and other mental disorders or medical conditions. Treatment options include high dose benzodiazepines (lorazepam) and electroconvulsive therapy (ECT) with some evidence for the effectiveness of glutamate antagonists. However, due to a lack of randomized controlled studies in this severely ill population, evidence base is weak. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402369PMC
February 2019
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Prolonged Post-Electroconvulsive Therapy Delirium Controlled With Donepezil.

J ECT 2019 Mar 13. Epub 2019 Mar 13.

Department of Neuropsychiatry Keio University School of Medicine and Center for Psychiatry and Behavioral Science Komagino Hospital Tokyo, Japan Department of Neuropsychiatry Keio University School of Medicine Tokyo, Japan

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http://dx.doi.org/10.1097/YCT.0000000000000590DOI Listing
March 2019
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Commentary on Braga et al: The Potential of Large Simple Trials to Determine the Real-World Effectiveness of Combined Electroconvulsive Therapy and Antipsychotics in Treating Patients With Treatment-Resistant Schizophrenia.

J ECT 2019 Mar 13. Epub 2019 Mar 13.

Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, Augusta, GA.

This commentary reflects upon the study of Braga et al of open-label continuation electroconvulsive therapy (ECT) plus clozapine in treatment-resistant schizophrenia (TRS), as reported in this issue of The Journal of ECT. The evidence base for ECT in TRS is scant, and the study of Braga et al is a step forward. However, their report raises other important questions including (1) what is the proper frequency of continuation ECT in TRS, and (2) should TRS patients, even TRS patients who have failed clozapine, receive acute ECT + clozapine, or is ECT + conventional antipsychotics sufficient? In this commentary, we examine these questions and outline a future research strategy for TRS that includes large simple trials. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000584DOI Listing
March 2019
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Is There a Change in Electroconvulsive Therapy Practice Following the New Mental Health Act 2014 in Victoria?: A Study at a Metropolitan Mental Health Service.

J ECT 2019 Mar 13. Epub 2019 Mar 13.

Clinical Services, North West Area Mental Health Service, Coburg.

Objectives: The main objective of our study was to examine whether there has been any change to electroconvulsive therapy (ECT) practice since the new Mental Health Act 2014 (MHA) in a public metropolitan mental health service in Victoria.

Methods: This retrospective study examined any change in ECT rate following the new MHA. We compared sociodemographic, clinical, and ECT-related variables for patients treated before (July 1, 2013, and June 30, 2014) and after (1st July 2014 and the 30th June 2015) the new MHA. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000581DOI Listing
March 2019
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1.387 Impact Factor

Commentary on Schotte et al. "Development of temporal lobe epilepsy during maintenance electroconvulsive therapy: A case of human kindling?"

Epilepsia Open 2019 Mar 25;4(1):206-209. Epub 2019 Jan 25.

Saul R. Korey Department of Neurology Isabelle Rapin Division of Child Neurology Dominick P. Purpura Department of Neuroscience Laboratory of Developmental Epilepsy Albert Einstein College of Medicine Einstein/Montefiore Epilepsy Center Montefiore Medical Center Bronx New York.

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http://dx.doi.org/10.1002/epi4.12296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398154PMC
March 2019
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Development of temporal lobe epilepsy during maintenance electroconvulsive therapy: A case of human kindling?

Epilepsia Open 2019 Mar 15;4(1):200-205. Epub 2019 Jan 15.

Department of Neurology University Hospitals Leuven Leuven Belgium.

We describe a patient with new-onset temporal lobe epilepsy during prolonged maintenance electroconvulsive therapy. We suggest a possible causal relationship with maintenance electroconvulsive therapy through electrical kindling of the temporal lobe. Read More

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http://dx.doi.org/10.1002/epi4.12294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398093PMC
March 2019
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Volume increase in the dentate gyrus after electroconvulsive therapy in depressed patients as measured with 7T.

Mol Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

University Groningen, University Medical Center Groningen, Department of Biomedical Sciences of Cells and Systems, Groningen, The Netherlands.

Electroconvulsive therapy (ECT) is the most effective treatment for depression, yet its working mechanism remains unclear. In the animal analog of ECT, neurogenesis in the dentate gyrus (DG) of the hippocampus is observed. In humans, volume increase of the hippocampus has been reported, but accurately measuring the volume of subfields is limited with common MRI protocols. Read More

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http://dx.doi.org/10.1038/s41380-019-0392-6DOI Listing
March 2019
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Subjective memory complaints after electroconvulsive therapy: systematic review.

BJPsych Bull 2019 Apr;43(2):73-80

Consultant,Devon Partnership NHS Trust,Exeter,UK.

Aims and methodFew studies have looked at subjective memory impairment from electroconvulsive therapy (ECT) after treatment completion. We aimed to systematically review all available evidence for subjective post-treatment effects. RESULTS: We included 16 studies in this review. Read More

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http://dx.doi.org/10.1192/bjb.2018.45DOI Listing

83 Catatonia in a 17-year-old Male Patient with Bipolar Disorder, a Case Study.

Authors:
Sultana Jahan

CNS Spectr 2019 Feb;24(1):217

Study Objective(s)Catatonia is not only present in adults; children & adolescents can suffer from catatonia but are often misdiagnosed. A study by Ghaziuddin, Dhossche and Marcotte (2012) found that 18 of the 101 child and adolescent patients had symptoms of catatonia, but only 2 actually had been given a diagnosis by their providers.

Method: 17-year-old male who was recently discharged from the inpatient psychiatric unit with the diagnosis of Major Depressive Disorder. Read More

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http://dx.doi.org/10.1017/S1092852919000622DOI Listing
February 2019
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Administration of Sub-anesthetic Dose of Ketamine and Electroconvulsive Treatment on Alternate Week Days in Patients with Treatment Resistant Depression: A Double Blind Placebo Controlled Trial.

Psychopharmacol Bull 2019 Feb;49(1):8-16

Altinay, MD, Karne, BS, Anand, MD, Center for Behavioral Health, Cleveland Clinic, Cleveland, ohio.

Introduction And Background: Patients with depression who fail to respond to at least two antidepressants in their current episode are considered to have Treatment Resistant Depression (TRD). ECT is an effective treatment of TRD but cognitive side effects limit its use. Ketamine elicits a rapid antidepressant response in sub-anesthetic repeated doses. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386425PMC
February 2019
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Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats.

Acta Neuropsychiatr 2019 Mar 11:1-29. Epub 2019 Mar 11.

Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen and Institute of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences,University of Copenhagen,Denmark.

Objective: Oxidative stress has been suggested to increase after electroconvulsive therapy (ECT); a treatment which continues to be the most effective for severe depression. Oxidative stress could potentially be mechanistically involved in both the therapeutic effects and side-effects of ECT.

Methods: We measured sensitive markers of systemic and CNS oxidative stress on DNA and RNA (urinary 8-oxodG/8-oxoGuo, cerebrospinal fluid 8-oxoGuo, and brain oxoguanine glycosylase mRNA expression) in male rats subjected to electroconvulsive stimulations (ECS); an animal model of ECT. Read More

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http://dx.doi.org/10.1017/neu.2019.7DOI Listing
March 2019
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