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    Temperature-dependent conformational dynamics of cytochrome c: Implications in apoptosis.
    J Mol Graph Model 2017 Oct 20;79:140-148. Epub 2017 Oct 20.
    Biomedical Research Lab, Department of Chemistry, VHNSN College (Autonomous), Virudhunagar, 626 001, Tamilnadu, India. Electronic address:
    Heat, electric shock, and burn injuries induce apoptosis by releasing cytochrome c (cyt-c) from mitochondria and by subsequently activating the death protease, caspases-3. During apoptosis, cyt-c undergoes changes in the secondary structure that have been suggested to increase its peroxidase activity. Information about these structural changes will provide better understanding of the apoptotic mechanism. Read More

    Neuromuscular electrical stimulation for the prevention of venous thromboembolism.
    Cochrane Database Syst Rev 2017 Nov 21;11:CD011764. Epub 2017 Nov 21.
    Liverpool Vascular and Endovascular Service, Royal Liverpool University Hospital, Prescot Street, Liverpool, UK, L7 8XP.
    Background: Venous thromboembolism (VTE) is a serious but preventable cause of morbidity and mortality. Neuromuscular electrical stimulation systems (NMES) for the prevention of VTE may be beneficial for patients in whom pharmacological or standard mechanical prophylaxis methods are contraindicated or are regarded as unsafe or impractical. Although findings of experimental studies suggest that NMES reduce venous stasis, the clinical utility and effectiveness of NMES in VTE prevention remain controversial. Read More

    Electro-Mechanical Response of a 3D Nerve Bundle Model to Mechanical Loads Leading to Axonal Injury.
    Int J Numer Method Biomed Eng 2017 Nov 21. Epub 2017 Nov 21.
    National University of Ireland Galway, Galway, Rep. of Ireland.
    Objective: Traumatic brain injuries and damage are major causes of death and disability. We propose a 3D fully coupled electro-mechanical model of a nerve bundle to investigate the electrophysiological impairments due to trauma at the cellular level.

    Methods: The coupling is based on a thermal analogy of the neural electrical activity by using the finite element software Abaqus CAE 6. Read More

    Some autonomic deficits of acute or chronic cervical spinal contusion reversed by interim brainstem stimulation.
    J Neurotrauma 2017 Nov 21. Epub 2017 Nov 21.
    University of Miami, The Miami Project to Cure Paralysis , 1095 NW 14th Terrace , Miami, Florida, United States , 33136 ;
    Prolonged electrical stimulation of the hindbrain's nucleus raphe magnus (NRM) or its major midbrain input region, the periaqueductal gray (PAG), was previously found in rats to promote recovery from sensory-motor and histological deficits of acute thoracic spinal cord injury (SCI). Here, some visceral deficits of acute and chronic midline cervical (C5) contusion are similarly examined. Cranially implanted wireless stimulators delivered intermittent 8 Hz, 30-70 µA cathodal pulse trains to a brainstem microelectrode. Read More

    Setting the pace: insights and advancements gained while preparing for an FES bike race.
    J Neuroeng Rehabil 2017 Nov 17;14(1):118. Epub 2017 Nov 17.
    Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH, 44106, USA.
    The reduction in physical activity following a spinal cord injury often leads to a decline in mental and physical health. Developing an exercise program that is effective and enjoyable is paramount for this population. Although functional electrical stimulation (FES) stationary cycling has been utilized in rehabilitation settings, implementing an overground cycling program for those with spinal cord injuries has greater technical challenges. Read More

    Hyperspectral Image Enhancement and Mixture Deep-Learning Classification of Corneal Epithelium Injuries.
    Sensors (Basel) 2017 Nov 16;17(11). Epub 2017 Nov 16.
    Centre of Excellent Signal and Image Processing, Department of Electronic and Electrical Engineering, University of Strathclyde, Glasgow G1 1XW, UK.
    In our preliminary study, the reflectance signatures obtained from hyperspectral imaging (HSI) of normal and abnormal corneal epithelium tissues of porcine show similar morphology with subtle differences. Here we present image enhancement algorithms that can be used to improve the interpretability of data into clinically relevant information to facilitate diagnostics. A total of 25 corneal epithelium images without the application of eye staining were used. Read More

    EEG dynamical correlates of focal and diffuse causes of coma.
    BMC Neurol 2017 Nov 15;17(1):197. Epub 2017 Nov 15.
    Department of Electrical and Systems Engineering, Washington University in St. Louis, 1 Brookings Dr. Campus Box 1042, St. Louis, MO, 63130, USA.
    Background: Rapidly determining the causes of a depressed level of consciousness (DLOC) including coma is a common clinical challenge. Quantitative analysis of the electroencephalogram (EEG) has the potential to improve DLOC assessment by providing readily deployable, temporally detailed characterization of brain activity in such patients. While used commonly for seizure detection, EEG-based assessment of DLOC etiology is less well-established. Read More

    Adding high-frequency transcutaneous electrical nerve stimulation to the first phase of post anterior cruciate ligament reconstruction rehabilitation does not improve pain and function in young male athletes more than exercise alone: a randomized single-blind clinical trial.
    Disabil Rehabil 2017 Nov 9:1-9. Epub 2017 Nov 9.
    a Neuromusculoskeletal Research center , Iran University of Medical Sciences , Tehran , Iran.
    Purpose: Knee ligamentous trauma and the following pain is one of the most prevalent athletic injuries. Transcutaneous electrical nerve stimulation is one of the conservative approaches in controlling pain which is low cost, noninvasive, and safe with low complications. Our purpose was to study whether transcutaneous electrical nerve stimulation (TENS) could help athletes perform better during the first phase of rehabilitation (0-4 weeks) after anterior cruciate ligament (ACL) reconstruction surgery and until the follow-up. Read More

    Reparative Effects of Poloxamer P188 in Astrocytes Exposed to Controlled Microcavitation.
    Ann Biomed Eng 2017 Nov 6. Epub 2017 Nov 6.
    Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, 60607, USA.
    Blast-induced traumatic brain injury (bTBI) is a neurological dysfunction that can result from a sudden exposure to shockwave and lead to adverse health consequences. Currently, there are no preventive measures that specifically target bTBI. Several hypotheses have been formulated to explain such injuries, including the generation of microcavitation (e. Read More

    Post electrical or lightning injury syndrome: a proposal for an American Psychiatric Association's Diagnostic and Statistical Manual formulation with implications for treatment.
    Neural Regen Res 2017 Sep;12(9):1405-1412
    Lightning Injury Research Program, University of Illinois at Chicago, Chicago, IL, USA.
    In the past, victims of electrical and lightning injuries have been assessed in a manner lacking a systematic formulation, and against ad hoc criteria, particularly in the area of neuropsychological disability. In this manner patients have, for example, only been partially treated, been poorly or incorrectly diagnosed, and have been denied the full benefit of compensation for their injuries. This paper contains a proposal for diagnostic criteria particularly for the neuropsychological aspects of the post injury syndrome. Read More

    Rapid Identification of Cortical Motor Areas in Rodents by High-Frequency Automatic Cortical Stimulation and Novel Motor Threshold Algorithm.
    Front Neurosci 2017 17;11:580. Epub 2017 Oct 17.
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Kanagawa, Japan.
    Cortical stimulation mapping is a valuable tool to test the functional organization of the motor cortex in both basic neurophysiology (e.g., elucidating the process of motor plasticity) and clinical practice (e. Read More

    Early structural changes of the heart after experimental polytrauma and hemorrhagic shock.
    PLoS One 2017 30;12(10):e0187327. Epub 2017 Oct 30.
    Institute of Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, Germany.
    Evidence is emerging that systemic inflammation after trauma drives structural and functional impairment of cardiomyocytes and leads to cardiac dysfunction, thus worsening the outcome of polytrauma patients. This study investigates the structural and molecular changes in heart tissue 4 h after multiple injuries with additional hemorrhagic shock using a clinically relevant rodent model of polytrauma. We determined mediators of systemic inflammation (keratinocyte chemoattractant, macrophage chemotactic protein 1), activated complement component C3a and cardiac troponin I in plasma and assessed histological specimen of the mouse heart via standard histomorphology and immunohistochemistry for cellular and subcellular damage and ongoing apoptosis. Read More

    Optical imaging for the assessment of hepatocyte metabolic state in ischemia and reperfusion injuries.
    Biomed Opt Express 2017 Oct 8;8(10):4419-4426. Epub 2017 Sep 8.
    Biopotonics Lab, Electrical Engineering Department, University of Wisconsin - Milwaukee, 3200 N Cramer St, Milwaukee, WI 53211, USA.
    Deterioration in mitochondrial function leads to hepatic ischemia and reperfusion injury (IRI) in liver surgery and transplantation. 3D optical cryoimaging was used to measure the levels of mitochondrial coenzymes NADH and FAD, and their redox ratio (NADH/FAD) gave a quantitative marker for hepatocyte oxidative stress during IRI. Using a rat model, five groups were compared: control, ischemia for 60 or 90 minutes (Isc60, Isc90), ischemia for 60 or 90 minutes followed by reperfusion of 24 hours (IRI60, IRI90). Read More

    Hand-to-hand coupling and strategies to minimize unintentional energy transfer during laparoscopic surgery.
    J Surg Res 2017 Nov 28;219:103-107. Epub 2017 Jun 28.
    Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado; Department of Surgery, Denver Veterans Affairs Medical Center, Denver, Colorado. Electronic address:
    Background: Energy-based devices are used in nearly every laparoscopic operation. Radiofrequency energy can transfer to nearby instruments via antenna and capacitive coupling without direct contact. Previous studies have described inadvertent energy transfer through bundled cords and nonelectrically active wires. Read More

    Trigeminal Neuralgia Following Lightning Injury.
    J Oral Facial Pain Headache 2017 Fall;31(4):e7-e9
    Lightning and other electrical incidents are responsible for more than 300 injuries and 100 deaths per year in the United States alone. Lightning strikes can cause a wide spectrum of neurologic manifestations affecting any part of the neuraxis through direct strikes, side flashes, touch voltage, connecting leaders, or acoustic shock waves. This article describes the first case of trigeminal neuralgia induced by lightning injury to the trigeminal nerve, thereby adding a new syndrome to the list of possible lightning-mediated neurologic injuries. Read More

    REAC regenerative treatment efficacy in experimental chondral lesions: a pilot study on ovine animal model.
    Clin Interv Aging 2017 14;12:1471-1479. Epub 2017 Sep 14.
    Department of Regenerative Medicine, Rinaldi Fontani Institute, Florence, Italy.
    Radioelectric asymmetric conveyor (REAC) technology is a platform designed to optimize cell polarity. Cell polarity is a universal biological phenomenon that is implicated in cell differentiation, proliferation, morphogenesis, aging, and rejuvenation. In this work, we investigate a timing and administration protocol for tissue optimization regenerative treatment type C, in order to treat aging-related chondral damage or injuries and gain insights into regenerative processes of articular cartilage in humans. Read More

    State-of-the-art robotic devices for ankle rehabilitation: Mechanism and control review.
    Proc Inst Mech Eng H 2017 Oct 1:954411917737584. Epub 2017 Oct 1.
    3 School of Mechanical Engineering, Faculty of Engineering, Computer and Mathematical Sciences, The University of Adelaide, Adelaide, SA, Australia.
    There is an increasing research interest in exploring use of robotic devices for the physical therapy of patients suffering from stroke and spinal cord injuries. Rehabilitation of patients suffering from ankle joint dysfunctions such as drop foot is vital and therefore has called for the development of newer robotic devices. Several robotic orthoses and parallel ankle robots have been developed during the last two decades to augment the conventional ankle physical therapy of patients. Read More

    Fuzzy logic-based mobile computing system for hand rehabilitation after neurological injury.
    Technol Health Care 2017 Oct 13. Epub 2017 Oct 13.
    Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
    Background: Effective neurological rehabilitation requires long term assessment and treatment. The rapid progress of virtual reality-based assistive technologies and tele-rehabilitation has increased the potential for self-rehabilitation of various neurological injuries under clinical supervision.

    Objective: The objective of this study was to develop a fuzzy inference mechanism for a smart mobile computing system designed to support in-home rehabilitation of patients with neurological injury in the hand by providing an objective means of self-assessment. Read More

    New conducted electrical weapons: Finite element modeling of safety margins.
    Conf Proc IEEE Eng Med Biol Soc 2017 Jul;2017:2170-2176
    Introduction-We have previously published on the ventricular fibrillation (VF) risk with TASER(®) X26 conducted electrical weapon (CEW). Our risk model accounted for realistic body mass index distributions, modeled the effects of partial or oblique dart penetration, and used epidemiological CEW statistics. As new CEWs have become available to law enforcement, their cardiac safety profile was not quantified. Read More

    Reduction in Fall Rate in Dementia Managed Care Through Video Incident Review: Pilot Study.
    J Med Internet Res 2017 Oct 17;19(10):e339. Epub 2017 Oct 17.
    Center for Information Technology Research in the Interest of Society and SafelyYou Inc. at SkyDeck (Chief Scientist), Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, United States.
    Background: Falls of individuals with dementia are frequent, dangerous, and costly. Early detection and access to the history of a fall is crucial for efficient care and secondary prevention in cognitively impaired individuals. However, most falls remain unwitnessed events. Read More

    Design of a Wireless Sensor System with the Algorithms of Heart Rate and Agility Index for Athlete Evaluation.
    Sensors (Basel) 2017 Oct 17;17(10). Epub 2017 Oct 17.
    Department of IT Fusion Technology, Graduate School, Chosun University, Gwangju 61452, Korea.
    Athlete evaluation systems can effectively monitor daily training and boost performance to reduce injuries. Conventional heart-rate measurement systems can be easily affected by artifact movement, especially in the case of athletes. Significant noise can be generated owing to high-intensity activities. Read More

    Abstracts and Workshops 7th National Spinal Cord Injury Conference November 9 - 11, 2017 Fallsview Casino Resort Niagara Falls, Ontario, Canada.
    J Spinal Cord Med 2017 Nov;40(6):813-869
    ga Clinical Scientist, Lyndhurst Centre, Toronto Rehabilitation Institute , University Health Network; and Assistant Professor, Department of Physical Therapy, University of Toronto.

    Case report of a high voltage electrical injury and review of the indications for early fasciotomy in limb salvage of an electrically injured limb.
    Ann Burns Fire Disasters 2017 Jun;30(2):150-153
    Department of Plastic and Reconstructive Surgery, Hospital Sungai Buloh, Selangor, Malaysia.
    Electrical injuries make up a relatively small portion of burn injuries. Safety measures in place on domestic electricity supply have reduced the occurrence of high voltage electrical injuries. We present the case of a young man who sustained a high voltage electrical injury on all four limbs. Read More

    Ann Burns Fire Disasters 2017 Jun;30(2):91-94
    Département de Médecine du travail, Médecine légale et Toxicologie, UFR Sciences Médicales, Université de Cocody, Abidjan, Cote d'Ivoire.
    The frequency of work-related electrical injuries has dropped but their characteristics remain unknown in our country. This survey aimed to describe the work-related electrical injuries that occurred in Yaounde during the period 2005-2014. The study was carried out in Yaounde-based central level hospitals from February 1st, 2015 to May 10th, 2015. Read More

    A novel approach for automatic visualization and activation detection of evoked potentials induced by epidural spinal cord stimulation in individuals with spinal cord injury.
    PLoS One 2017 11;12(10):e0185582. Epub 2017 Oct 11.
    Frazier Rehab Institute, Kentucky One Health, Louisville, KY, United States of America.
    Voluntary movements and the standing of spinal cord injured patients have been facilitated using lumbosacral spinal cord epidural stimulation (scES). Identifying the appropriate stimulation parameters (intensity, frequency and anode/cathode assignment) is an arduous task and requires extensive mapping of the spinal cord using evoked potentials. Effective visualization and detection of muscle evoked potentials induced by scES from the recorded electromyography (EMG) signals is critical to identify the optimal configurations and the effects of specific scES parameters on muscle activation. Read More

    Efficacy and factors determining the outcome of dorsal root entry zone lesioning procedure (DREZotomy) in the treatment of intractable pain syndrome.
    Acta Neurochir (Wien) 2017 Dec 9;159(12):2431-2442. Epub 2017 Oct 9.
    Division of Neurosurgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Background: Chronic pain is a disabling condition that adversely affects patient quality of life. The dorsal root entry zone lesioning procedure (DREZotomy) is a modality used to treat intractable pain caused by insults to neural structures. This study aimed to investigate the efficacy of and the factors that determine the outcome of microsurgical DREZotomy (MDT). Read More

    Lower amputation rate after fasciotomy by straight midline incision technique for a 22,900-V electrical injury to the upper extremities.
    Injury 2017 Nov 28;48(11):2590-2596. Epub 2017 Sep 28.
    Department of Orthopaedic Surgery, Hanil General Hospital, Seoul, Korea. Electronic address:
    Purpose: The purpose of this study is to compare the major amputation rate following two different fasciotomy techniques, conventional versus straight midline, in patients with high-voltage arc burn injury by electric currents of 22,900V to the upper extremities.

    Methods: A retrospective analysis of 230 patients (270 burned upper limbs) who underwent fasciotomy after high-voltage electrical injuries between 1996 and 2007 was performed. The patients were divided into two groups according to the fasciotomy method used. Read More

    Groin Flap in Paediatric Age Group to Salvage Hand after Electric Contact Burn: Challenges and Experience.
    J Clin Diagn Res 2017 Aug 1;11(8):PC01-PC03. Epub 2017 Aug 1.
    Resident, Department of Plastic Surgery, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.
    Introduction: Electric contact burn is characterised by multiple wounds produced by entrance and exit of the current. Hand is most commonly involved in the same and children are particularly susceptible to such accidents.

    Aim: To document effectiveness and challenges associated with the use of groin flap as an initial definitive treatment of electric contact burn in paediatric age group. Read More

    Blunt thoracic trauma and cardiac injury in the athlete: contemporary management.
    J Sports Med Phys Fitness 2017 Sep 29. Epub 2017 Sep 29.
    Department of Biomorphology and Functional Imaging, Post-Graduate Medical School on Sports Medicine, Università degli Studi di Messina, Messina, Italy.
    Introduction: Commotion cordis and cardiac injuries are rare events usually following a chest blunt trauma during sports activities.

    Evidence Acquisition And Synthesis: Various aetiologies have been identified to cause electrical (commotion cordis) and/or structural (contusion and further injuries) damage, but high-velocity tools such as baseballs or hockey pucks (also called projectiles) have been chiefly identified. Clinical consequences are challenging, varying from uncomplicated supraventricular arrhythmias to cardiac wall rupture. Read More

    Acta Ortop Bras 2017 Jul-Aug;25(4):147-150
    . Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Department of Biomechanics, Medicine, and Locomotor System Rehabilitation, Curso de Fisioterapia, Ribeirão Preto, SP, Brazil.
    Objective: The aim of this study was to evaluate functional independence and trunk control during maximum-range tasks in individuals with spinal cord injuries, who were divided into sedentary (SSI, n=10) and physically active (PASI, n=10) groups .

    Methods: Anamnesis was conducted and level and type of injury were identified (according to the American Spinal Injury Association protocol, ASIA) and the Functional Independence Measure (FIM) questionnaire was applied. For the forward and lateral reach task, the subjects were instructed to reach as far as possible. Read More

    Acute-Onset Quadriplegia With Recovery After High-Voltage Electrical Injury.
    Ann Plast Surg 2017 Nov;79(5):e33-e36
    From the *Michigan State University College of Human Medicine; †Plastic and Reconstructive Surgery Residency, Grand Rapids Medical Education Partners; and ‡Spectrum Health Regional Burn Center, Grand Rapids, MI.
    Although uncommon, electrical injuries are associated with significant morbidity and mortality. There have been several reports of neurological sequelae secondary to electrical injury; however, the neurophysiology is still not completely understood. These neurological complications pose the greatest risk for permanent disability. Read More

    [Molecular and cellular mechanisms of damage to renal parenchyma in renal warm ischemia].
    Urologiia 2017 Sep(4):79-84
    St. Lukes Clinical Hospital, St. Petersburg, Russia.
    Warm ischemia of the renal parenchyma is a forced feature of laparoscopic partial nephrectomy. It is accompanied by oxygen deprivation of the organ and followed by re-oxygenation, which can cause additional damage to the renal tissue. This damage can result in acute functional and structural disorders of individual parts of the nephron, increasing the risk for a renal dysfunction. Read More

    Utilizing Physiological Principles of Motor Unit Recruitment to Reduce Fatigability of Electrically-Evoked Contractions: A Narrative Review.
    Arch Phys Med Rehabil 2017 Sep 19. Epub 2017 Sep 19.
    Human Neurophysiology Laboratory, Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada. Electronic address:
    Neuromuscular electrical stimulation (NMES) is used to produce contractions to restore movement and reduce secondary complications for individuals experiencing motor impairment. NMES is conventionally delivered through a single pair of electrodes over a muscle belly or nerve trunk using short pulse durations and frequencies between 20 and 40Hz (conventional NMES). Unfortunately, the benefits and widespread use of conventional NMES are limited by contraction fatigability, which is in large part because of the nonphysiological way that contractions are generated. Read More

    Building a resistance to ignition testing device for sunglasses and analysing data: a continuing study for sunglasses standards.
    Biomed Eng Online 2017 Sep 21;16(1):114. Epub 2017 Sep 21.
    Electrical Engineering Department, Engineering School of São Carlos, University of São Paulo, Av. Trabalhador Sãocarlense 400, São Carlos, SP, 13566-590, Brazil.
    Background: Sunglasses popularity skyrocketed since its advent. The ongoing trend led to the creation of standards to protect consumers from injuries and secondary hazards due to spectacles use. In Brazil, the corresponding standard is NBR ISO 12312-1:2015 and since there is no mandatory testing, evaluating sunglasses performance provides an insight into compliance with the standard. Read More

    Electromagnetic Fields for the Regulation of Neural Stem Cells.
    Stem Cells Int 2017 28;2017:9898439. Epub 2017 Aug 28.
    Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
    Localized magnetic fields (MFs) could easily penetrate the scalp, skull, and meninges, thus inducing an electrical current in both the central and peripheral nervous systems, which is primarily used in transcranial magnetic stimulation (TMS) for inducing specific effects on different regions or cells that play roles in various brain activities. Studies of repetitive transcranial magnetic stimulation (rTMS) have led to novel attractive therapeutic approaches. Neural stem cells (NSCs) in adult human brain are able to self-renew and possess multidifferential ability to maintain homeostasis and repair damage after acute central nervous system. Read More

    Bioimpedance technology for detection of thoracic injury.
    Physiol Meas 2017 Oct 31;38(11):2000-2014. Epub 2017 Oct 31.
    Department of Electrical Engineering, Chalmers University of Technology, Gothenburg, Sweden. MedTech West, Sahlgrenska University Hospital, Gothenburg, Sweden. SAFER Vehicle and Traffic Safety Centre at Chalmers, Gothenburg, Sweden. Department of Information Technology, University of Borås, Borås, Sweden.
    Objective: Thoracic trauma is one of the most common and lethal types of injury, causing over a quarter of traumatic deaths. Severe thoracic injuries are often occult and difficult to diagnose in the field. There is a need for a point-of-care diagnostic device for severe thoracic injuries in the prehospital setting. Read More

    The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury.
    PLoS One 2017 19;12(9):e0184888. Epub 2017 Sep 19.
    Dept. of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
    Background: The novel nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone holds promise to be safe and efficient in the treatment of patients with heart failure and/or chronic kidney disease. However, its effects on vascular function remain elusive.

    Purpose: The aim of this study was to determine the functional effect of selective MR antagonism by finerenone in vascular cells in vitro and the effect on vascular remodeling following acute vascular injury in vivo. Read More

    The concept of protective nerve stimulation for ultrasound guided nerve blocks.
    Med Hypotheses 2017 Sep 16;107:72-73. Epub 2017 Aug 16.
    Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Germany.
    Regional plexus and nerve blocks are a common technique in modern anesthesia. Since ultrasound machines are available in many departments, the role of nerve stimulation is highly discussed and different approaches to perform the blocks are taken into account. Common technique for electrical nerve stimulation is searching for a stimulating threshold of 0. Read More

    Increasing bladder capacity by foot stimulation in rats with spinal cord injuries.
    BMC Urol 2017 Sep 15;17(1):85. Epub 2017 Sep 15.
    Department of Urology, China Rehabilitation Research Center, Beijing, 100068, China.
    Background: This study was to explore the possibility that foot stimulation increased bladder capacity(BC) in rats with neurogenic bladder secondary to T10 spinal cord injuries.

    Methods: In 20 awake rats (stimulation group) with T10 spinal cord injuries, 5 repeat cystometrograms (CMGs) were recorded. The 1st and 2nd CMGs were performed without stimulation. Read More

    Atypical Exit Wound in High-Voltage Electrocution.
    Am J Forensic Med Pathol 2017 Dec;38(4):336-338
    From the *Forensic Medicine & Toxicology, JIPMER, Puducherry; and †Forensic Medicine & Toxicology, Government Villupuram Medical College, Villupuram, Tamil Nadu, India.
    Electrocution fatality cases are difficult to investigate. High-voltage electrocution burns resemble burns caused by other sources, especially if the person survives for few days. In that case, circumstantial evidence if correlated with the autopsy findings helps in determining the cause and manner of death. Read More

    Long-Term Performance and User Satisfaction With Implanted Neuroprostheses for Upright Mobility After Paraplegia: 2- to 14-Year Follow-Up.
    Arch Phys Med Rehabil 2017 Sep 9. Epub 2017 Sep 9.
    Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH.
    Objective: To quantify the long-term (>2y) effects of lower extremity (LE) neuroprostheses (NPs) for standing, transfers, stepping, and seated stability after spinal cord injury.

    Design: Single-subject design case series with participants acting as their own concurrent controls, including retrospective data review.

    Setting: Hospital-based clinical biomechanics laboratory with experienced (>20y in the field) research biomedical engineers, a physical therapist, and medical monitoring review. Read More

    Applications of 256-Slice, Spiral Computed Tomography Perfusion Scanning in Limb Salvage After High-Voltage Electrical Injury.
    Disaster Med Public Health Prep 2017 Sep 13:1-8. Epub 2017 Sep 13.
    3Department of Radiology,Shanxi Province Hospital of Traditional Chinese Medicine Hospital,Taiyuan,China.
    Objective: This study aimed to investigate the applications of intelligent 256-slice computed tomography (iCT) perfusion imaging in high-voltage electrical injuries (HVEIs).

    Methods: 256-slice iCT was used to perform perfusion scanning for 48 patients with HVEI to detect the perfusion parameters.

    Results: The blood flow (BF) and peak enhancement intensity (PEI) values of the plane lower than the amputation level of the diseased side (ALD) were smaller than those of the corresponding healthy side (P<0. Read More

    Systematic review: Lost-time injuries in the US mining industry.
    Occup Med (Lond) 2017 Aug;67(6):442-447
    Laurentian University, Sudbury, Ontario, Canada.
    Background: The mining industry is associated with high levels of accidents, injuries and illnesses. Lost-time injuries are useful measures of health and safety in mines, and the effectiveness of its safety programmes.

    Aims: To identify the type of lost-time injuries in the US mining workforce and to examine predictors of these occupational injuries. Read More

    American football and other sports injuries may cause migraine/persistent pain decades later and can be treated successfully with electrical twitch-obtaining intramuscular stimulation (ETOIMS).
    BMJ Innov 2017 Apr 24;3(2):104-114. Epub 2017 Mar 24.
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
    Introduction: Autonomous twitch elicitation at myofascial trigger points from spondylotic radiculopathies-induced denervation supersensitivity can provide favourable pain relief using electrical twitch-obtaining intramuscular stimulation (ETOIMS).

    Aim: To provide objective evidence that ETOIMS is safe and efficacious in migraine and persistent pain management due to decades-old injuries to head and spine from paediatric American football.

    Methods And Materials: An 83-year-old mildly hypertensive patient with 25-year history of refractory migraine and persistent pain self-selected to regularly receive fee-for-service ETOIMS 2/week over 20 months. Read More

    Protocol for Usability Testing and Validation of the ISO Draft International Standard 19223 for Lung Ventilators.
    JMIR Res Protoc 2017 Sep 8;6(9):e166. Epub 2017 Sep 8.
    Department of Systems Design Engineering, University of Waterloo, Waterloo, ON, Canada.
    Background: Clinicians, such as respiratory therapists and physicians, are often required to set up pieces of medical equipment that use inconsistent terminology. Current lung ventilator terminology that is used by different manufacturers contributes to the risk of usage errors, and in turn the risk of ventilator-associated lung injuries and other conditions. Human factors and communication issues are often associated with ventilator-related sentinel events, and inconsistent ventilator terminology compounds these issues. Read More

    Bigger is better: comparison of alternative devices for tension hemopneumothorax and pulseless electrical activity in a yorkshire swine model.
    J Trauma Acute Care Surg 2017 Sep 5. Epub 2017 Sep 5.
    1Department of Surgery, Naval Medical Center Portsmouth, Portsmouth, Virginia 2Combat Trauma Research Group, Naval Medical Center Portsmouth, Portsmouth, Virginia 3Madigan Army Medical Center, Tacoma, Washington 4Navy Trauma Training Center, LAC+USC Medical Center, Los Angeles, California.
    Background: Tension pneumothorax is a cause of potentially preventable death in pre-hospital and battlefield settings and 14g angiocatheter (14G AC) decompression remains the current treatment standard, despite its high incidence of failure. Traumatic pneumothorax is often associated with hemothorax, but 14G AC has no proven efficacy for associated hemothorax. We sought to compare the 14G AC to three alternative devices for treatment of tension hemopneumothorax (t-H/PTX) in a positive pressure ventilation swine model. Read More

    Acute and chronic exposure to high levels of glucose modulates tight junction-associated epithelial barrier function in a renal tubular cell line.
    Life Sci 2017 Nov 5;188:149-157. Epub 2017 Sep 5.
    Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil. Electronic address:
    Aims: Type 2 diabetes mellitus (T2DM) is one of the most prevalent diseases worldwide. Diabetic nephropathy (DN) is a complication of diabetes and the mechanisms underlying onset and progression of this disease are not fully understood. It has been shown that hyperglycemia is an independent factor to predict the development of DN in individuals with T2DM, however, a link between high plasma glucose levels and renal tubular injuries in DN remains unknown. Read More

    Head-Eye Vestibular Motion Therapy Affects the Mental and Physical Health of Severe Chronic Postconcussion Patients.
    Front Neurol 2017 22;8:414. Epub 2017 Aug 22.
    Neurology, Carrick Institute, Cape Canaveral, FL, United States.
    Context: Approximately 1.8-3.6 million annual traumatic brain injuries occur in the United States. Read More

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