Circ Arrhythm Electrophysiol 2022 Mar 3;15(3):e010630. Epub 2022 Mar 3.
Department of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).
Background: Right ventricular outflow tract (RVOT) is a common source of ventricular tachycardia, which often requires ablation. However, the mechanisms underlying the RVOT's unique arrhythmia susceptibility remain poorly understood due to lack of detailed electrophysiological and molecular studies of the human RVOT.
Methods: We conducted optical mapping studies in 16 nondiseased donor human RVOT preparations subjected to pharmacologically induced adrenergic and cholinergic stimulation to evaluate susceptibility to arrhythmias and characterize arrhythmia dynamics. Read More