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Public Health 2020 May 28;183:112-117. Epub 2020 May 28.

University of Education, Department of Health Administration, P. O. Box 25, Winneba, Ghana. Electronic address:

Objectives: Despite liberal abortion laws, unsafe abortions remain a public health challenge in Ghana. This study examines implications of financial cost of abortion in assessing safer services for young people in Ghana.

Study Design: This is a retrospective cross-sectional mixed-method study. Read More

Eur J Contracept Reprod Health Care 2020 May 28:1-5. Epub 2020 May 28.

Obstetrics Service, Department of Women and Reproductive Medicine, Centro Hospitalar Universitário do Porto, EPE, Centro Materno Infantil do Norte, Oporto, Portugal.

In Portugal, a country with strong Catholic roots, elective termination of pregnancy at women's request is still stigmatised, especially if it is a repeat abortion. The objectives of this study were to determine the incidence of repeat abortion, taking into account the contraceptive method chosen after the index abortion event, and characterise the risk factors for repeat abortion. This was a retrospective cohort study of 988 women who requested termination of pregnancy during 2015 in a Portuguese tertiary care public hospital. Read More

Obstet Gynecol 2020 Jun;135(6):1296-1305

Department of Family and Community Medicine, University of California, San Francisco, San Francisco; Advancing New Standards in Reproductive Health (ANSIRH) and the Bixby Center for Global Reproductive Health, Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California, San Francisco; and the University of California, Berkeley, School of Public Health.

Objective: To evaluate the prevalence and features of policies regulating abortion in U.S. teaching hospitals. Read More

BMC Med Genomics 2020 May 13;13(1):68. Epub 2020 May 13.

Departments of Neurosciences and Pediatrics, Rady Children's Institute for Genomic Medicine, Howard Hughes Medical Institute, University of California San Diego, La Jolla, CA, 92093, USA.

Background: The causes for thousands of individually rare recessive diseases have been discovered since the adoption of next generation sequencing (NGS). Following the molecular diagnosis in older children in a family, parents could use this information to opt for fetal genotyping in subsequent pregnancies, which could inform decisions about elective termination of pregnancy. The use of NGS diagnostic sequencing in families has not been demonstrated to yield benefit in subsequent pregnancies to reduce recurrence. Read More

Cell Commun Signal 2020 May 12;18(1):73. Epub 2020 May 12.

Department of Gynecology of Integrated Traditional Chinese and Western Medicine, Hospital of Obstetrics and Gynecology, Fudan University, Shen Yang Road 128, Shanghai, 200090, People's Republic of China.

Background: The crosstalk between trophoblast cells and decidual NK cells plays an important role in the establishment and maintenance of normal pregnancy. Recent studies reported that autophagy can induce immune tolerance at the maternal fetal interface, while the mechanism remains unclear.

Methods: Autophagy levels in the villi of normal and recurrent spontaneous abortion (RSA) patients were detected by transmission electron microscopy. Read More

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 May;37(5):547-550

Department of Gynecology and Obstetrics, Shengjing Hospital Affiliated to China Medical University, Key Laboratory of Maternal Fetal Medicine of Liaoning Province, Shenyang, Liaoning 110004, China.

Objective: To analyze the clinical features and pathogenesis of a fetus with holoprosencephaly.

Methods: The findings of prenatal ultrasonography was reviewed. Following elective abortion, whole exome sequencing (WES) was carried out to identify potential pathogenic variant. Read More

Hum Reprod 2020 Apr;35(4):751-758

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Pharmakovigilanz- und Beratungszentrum für Embryonaltoxikologie, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany.

Study Question: Is the failure of the selective progesterone receptor modulator ulipristal acetate (UPA) as emergency contraception (EC; 30 mg, single) or inadvertent exposure for myoma treatment (5 mg/d) in pregnancy associated with a higher risk of birth defects, spontaneous abortion (SAB) or elective termination of pregnancy (ETOP)?

Summary Answer: We did not find an increased risk for birth defects, SABs or ETOPs after UPA exposure during implantation and early embryogenesis.

What Is Known Already: Pregnancy outcome data after exposure to UPA are very limited. In cases of EC failure or unplanned pregnancy during myoma treatment, women need well-grounded risk assessment to minimize anxiety and prevent unjustified termination of pregnancy. Read More

N Engl J Med 2020 May 9;382(19):e47. Epub 2020 Apr 9.

From Harvard Medical School (M.J.B., D.B.) and the Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital (D.B.) - both in Boston; and the Departments of Medical Social Sciences, Medical Education, and Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago (K.L.W.).

Facts Views Vis Obgyn 2019 Sep;11(3):217-222

Department of Obstetrics, Gynecology and Reproductive Sciences. University of Miami. Miller School of Medicine. Miami FL. USA.

Background: Retained products of conception (RPOC) are defined as the presence of tissue inside the uterine cavity after delivery or termination of a pregnancy. Operative hysteroscopy is associated with increased surgical success and decreased postoperative formation of intrauterine adhesions. The aim of this study is to report our experience in hysteroscopic management of RPOC. Read More

Eur J Med Genet 2020 May 20;63(5):103852. Epub 2020 Jan 20.

New York University Langone Fertility Center, 660 First Ave, 5th Floor, New York, NY, 10016, USA.

We investigated clinical error rates with single thawed euploid embryo transfer (STEET) diagnosed by next generation sequencing (NGS) and array comparative genomic hybridization (aCGH). A total of 1997 STEET cycles after IVF with preimplantation genetic testing for aneuploidy (PGT-A) from 2010 to 2017 were identified; 1151 STEET cycles utilized NGS, and 846 STEET cycles utilized aCGH. Any abortions, spontaneous or elective, in which products of conception (POCs) were collected were reviewed. Read More

Aust N Z J Obstet Gynaecol 2020 Jan 8. Epub 2020 Jan 8.

College of Medicine and public Health, Flinders University, Darwin, Northern Territory, Australia.

Background: Women face challenges when accessing abortion, including varied legislation and reduced access to services in rural and remote settings. There are limited clinical guidelines in Australia and little information regarding the patient journey, particularly the timeframe between referral to abortion procedure. Legislation reform in the Northern Territory (NT) legalised early medical abortion (EMA) in primary health care, providing an opportunity to review service provision of elective surgical abortion prior to and after these changes. Read More

BMJ Case Rep 2019 Dec 31;12(12). Epub 2019 Dec 31.

Emergency Department, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.

Takotsubo's syndrome is a rare acute reversible heart failure, where the pathophysiology is not fully understood. It is being increasingly diagnosed in varied clinical contexts, which can result in atypical presentations in the context of surgical or anaesthetic stress. We discuss the case of a 22-year-old woman who developed cardiogenic shock and impaired left ventricular function after an elective gynaecological procedure. Read More

Reproduction 2019 Dec 1. Epub 2019 Dec 1.

Y Lin, The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Institute of Embryo-Fetal Original Adult Disease, Shanghai, China.

Abnormal growth and migration of trophoblast cells is one of the main causes of spontaneous abortion. Eukaryotic translation initiation factor 5A (eIF5A) plays an important role in trophoblast cell growth and migration; however, its underlying mechanism remains largely unknown. Here, we firstly confirmed that eIF5A knockdown reduced human chorionic trophoblast HTR8 cells viability, proliferation, and migration. Read More

Hum Vaccin Immunother 2019 Dec 12:1-12. Epub 2019 Dec 12.

GSK, Wavre, Belgium.

This manuscript discloses end-of-study safety data of a community-randomized controlled trial in Finland (NCT00534638), assessing the effectiveness of two vaccination strategies (gender-neutral versus females only) using the AS04-adjuvanted human papillomavirus (HPV)-16/18 (AS04-HPV-16/18) vaccine. The total vaccination cohort included 32,175 adolescents aged 12-15 y at vaccination of whom 14,837 received the AS04-HPV-16/18 vaccine and 17,338 received the hepatitis-B virus vaccine (control). Spontaneous reporting of serious adverse events (SAEs) combined with surveillance using nation-wide health registries showed an acceptable safety profile of the AS04-HPV-16/18 vaccine. Read More

Open Forum Infect Dis 2019 Dec 4;6(12):ofz486. Epub 2019 Dec 4.

GSK, Wavre, Belgium.

Objective: Data on human papillomavirus (HPV) prevalence around pregnancy were inconsistent. We assessed HPV prevalence before and after pregnancy, HPV incidence after pregnancy, and risk factors for HPV infection.

Method: Data from 15 754 women in control arms of 5 AS04-HPV-16/18 vaccine efficacy trials were analyzed, including 3001 women with at least 1 pregnancy. Read More

Stat Med 2020 Feb 1;39(4):481-493. Epub 2019 Dec 1.

Institute of Statistics, Ulm University, Ulm, Germany.

Both delayed study entry (left-truncation) and competing risks are common phenomena in observational time-to-event studies. For example, in studies conducted by Teratology Information Services (TIS) on adverse drug reactions during pregnancy, the natural time scale is gestational age, but women enter the study after time origin and upon contact with the service. Competing risks are present, because an elective termination may be precluded by a spontaneous abortion. Read More

Theor Med Bioeth 2019 Dec;40(6):565-581

Albert Gnaegi Center for Health Care Ethics, Saint Louis University, 3545 Lafayette Ave., Salus 527, Saint Louis, MO, 63104, USA.

Recently, debate over whether health care providers should have a protected right to conscientiously refuse to offer legal health care services-such as abortion, elective sterilization, aid in dying, or treatments for transgender patients-has grown exponentially. I advance a modified compromise view that bases respect for claims of conscientious refusal to provide specific health care services on a publicly defensible rationale. This view requires health care providers who refuse such services to disclose their availability by other providers, as well as to arrange for referrals or facilitate transfers of care. Read More

J Obstet Gynaecol Can 2020 May 12;42(5):637-639. Epub 2019 Nov 12.

Department of Obstetrics & Gynaecology, University of British Columbia, Vancouver BC.

Background: This report describes an unusual case of a retained hygroscopic osmotic dilator following second trimester dilation and evacuation.

Case: A 24-year-old woman presented for elective pregnancy termination at 16 weeks gestational age. A cervical osmotic dilator could not be retrieved and fractured on attempted removal. Read More

BMC Pregnancy Childbirth 2019 Oct 25;19(1):382. Epub 2019 Oct 25.

Department of General Surgery, Medical University of Graz, Auenbruggerplatz 29, A-8036, Graz, Austria.

Background: Diagnosis and management of non-obstetric abdominal pathologies during pregnancy are clinically challenging for both obstetricians and general surgeons. Our aim was to evaluate the outcome of pregnant patients who had undergone non-obstetric abdominal surgery.

Methods: We retrospectively reviewed 76 pregnant patients who had required surgery for non-obstetric abdominal pathologies during pregnancy at our department from January 2005 to December 2015. Read More

Fam Med 2019 Oct;51(9):750-755

Department of Family Medicine, University of Washington, Seattle, WA.

Background And Objectives: The role of training in the declining rate of family physicians' provision of women's reproductive health care is unclear. No requirements for abortion training exist, and curricula vary widely. This study assessed the impact of program-level abortion training availability on graduates' feelings of training adequacy and their postgraduate practice in reproductive health. Read More

J Glob Oncol 2019 09;5:1-11

Basaveshwara Engineering College, Bagalkot, India.

Purpose: The aim of the current work was to report the effect of imatinib on pregnancy in patients with chronic myeloid leukemia (CML).

Methods: Data were collected between January 1998 and December 2014. One hundred four patients met inclusion criteria, and we report the results of 104 pregnancies-conceived by the participant or partner-while being on imatinib therapy for CML. Read More

Am J Obstet Gynecol 2020 03 14;222(3):273.e1-273.e9. Epub 2019 Sep 14.

Bixby Center for Global Reproductive Health, University of California, San Francisco, San Francisco, CA.

Background: Catholic and other faith-based hospitals often restrict family planning service provision based on institutional doctrine. Approximately 11% of US accredited obstetrics and gynecology residency programs occur at such hospitals, creating a challenge to educational leaders who must ensure comprehensive family planning training.

Objective: To evaluate and summarize family planning training at obstetrics and gynecology residency programs that are affiliated with Catholic and other faith-based hospitals that restrict reproductive services. Read More

Best Pract Res Clin Obstet Gynaecol 2020 Jan 1;62:63-78. Epub 2019 Aug 1.

Research Division, Faculty of Medicine, National Autonomous University of Mexico, Mexico. Electronic address:

Latin America hosts the most restrictive abortion legislation globally. In 2007, Mexico, the second largest Catholic country in the world, decriminalized elective abortion within the first twelve weeks of pregnancy in the capital: Mexico City (also known as Federal District of Mexico). Following the reform, the Mexico City Ministry of Health (MX-MOH) implemented safe and legal services. Read More

Surg Technol Int 2019 11;35:173-184

Center for Menstrual Disorders, Rochester, New York.

The gynecologist's office was, historically speaking, the original setting for surgical practice. In 1809, Ephraim McDowell performed the first ovariotomy and removed a 22.5-pound tumor from Jane Crawford in his Danville, Kentucky office-decades before the development of anesthesia or the aseptic technique. Read More

Minim Invasive Ther Allied Technol 2019 Aug 21:1-5. Epub 2019 Aug 21.

Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University School of Medicine , Seongnam , Korea.

To assess the effectiveness and safety of non-surgical management for six heterotopic interstitial pregnancies. We retrospectively analyzed the data of six women diagnosed with heterotopic interstitial pregnancies who underwent non-surgical treatment at the CHA Bundang Medical Center between January 2007 and December 2017. Three heterotopic interstitial pregnancies were treated with sono-guided potassium chloride (KCl) injections. Read More

CMAJ 2019 08;191(33):E916-E918

Division of Infectious Diseases (Billick, Gold), Department of Medicine (Gold), University of Toronto, Toronto, Ont.

J Vasc Interv Radiol 2019 Nov 10;30(11):1750-1758. Epub 2019 Aug 10.

Department of Radiology, Beth Israel Deaconess Medical Center, One Deaconess Rd., WCC-3, Boston, MA 02215. Electronic address:

Purpose: To evaluate the technical and clinical success rates and safety of bilateral gelfoam uterine artery embolization (UAE) for symptomatic acquired uterine arteriovenous shunting due to prior obstetric or gynecologic event.

Materials And Methods: This was a retrospective study of consecutive patients of reproductive age who presented with abnormal uterine bleeding after recent gynecologic procedures or obstetric events between January 2013 and February 2018. Bilateral UAE was performed in all patients using gelfoam slurry. Read More

J Dairy Sci 2019 Oct 7;102(10):9236-9240. Epub 2019 Aug 7.

Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus 43210. Electronic address:

Transrectal palpation of the reproductive tract is the most common method for pregnancy determination in cattle and is considered a veterinary skill that new veterinary medicine (DVM) graduates should perform proficiently. However, using privately owned cattle to train students can be difficult because producers may believe that transrectal palpation by inexperienced students increases the risk of pregnancy wastage compared with examination by an experienced clinician. We used a randomized field trial of 1,216 healthy Holstein and Jersey cattle in 2 commercial dairy herds to estimate the effect of veterinary student transrectal palpation on early pregnancy loss. Read More

Med Arch 2019 Apr;73(2):126-130

Department of Obstetrics and Gynecology, Clinical Hospital "Sveti Duh", Zagreb and Croatian Catholic University Zagreb, Croatia.

Introduction: There are many ethical and moral dilemmas regarding the termination of pregnancy(TOP) with severe fetal anomalies.

Aim: Our aim is to present a case of severe fetal hydrocephalus (HCP), spina bifida aperta and, meningomyelocoella (MMC).

Case Report: A gynecologist examined a 23-year-old patient with vital pregnancy of 24/25 week of gestation (WG) with the anomaly of the fetus. Read More

Clin Sci (Lond) 2019 06 20;133(12):1341-1352. Epub 2019 Jun 20.

Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Preeclampsia (PE) is a pregnancy complication, featuring elevated blood pressure and proteinuria, with no appropriate treatment. Activation of the endothelin system has emerged as an important pathway in PE pathophysiology based on experimental PE models where endothelin receptor antagonists (ERAs) prevented or attenuated hypertension and proteinuria. Hence, ERAs have been suggested as potential therapy for PE. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Jul 16;238:157-163. Epub 2019 May 16.

Institution of Clinical Sciences, Department of Obstetrics and Gynaecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

Objective: Cervical ripening resembles an inflammatory process in many aspects, involving invasion of inflammatory cells, collagen breakdown and remodelling of the extracellular matrix. Mast cells produce a variety of inflammatory agents and are attributed a functional role in cervical ripening. The aim of this study was to examine if cervical mast cells are increased in number and stimulated during pregnancy. Read More

Contraception 2019 09 29;100(3):188-192. Epub 2019 May 29.

Institute for Family Health, 2006 Madison Ave, 5th Floor, New York, NY 10035, USA. Electronic address:

Objective: Among family physicians who graduated from residencies with abortion training, we explore the association between intention to provide abortion at the end of residency and abortion provision 5 years postresidency.

Study Design: We invited 2009-2012 graduates from US family medicine residency programs with a required opt-out abortion training rotation or elective abortion training opportunities, and who had completed a baseline end-of-residency survey (N=477) to take our follow-up survey 5 years postresidency (2014-2017). We used logistic regression to examine the association between intention to provide abortion postresidency and abortion provision 5 years later. Read More

Mult Scler 2019 May 30:1352458519851245. Epub 2019 May 30.

The Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark/Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Background: A diagnosis of multiple sclerosis (MS) may impact the choice of parenthood.

Objective: To investigate the number of live births, abortions and ectopic pregnancies among persons with MS.

Methods: From the Danish Multiple Sclerosis Registry, we extracted data from all persons diagnosed with MS from 1960 to 1996 and matched each MS person with four reference persons. Read More

Pediatr Dev Pathol 2019 Oct 24;22(5):456-460. Epub 2019 May 24.

Department of Pathology, SUNY Downstate Medical Center, Brooklyn, New York.

Introduction: P-glycoprotein the highly conserved mammalian adenosine triphosphate-binding cassette transmembrane multidrug protein transporter is involved in peri-implantation events and fetal placental development. Greater expression in early versus late pregnancy and localization in both syncytio- and cytotrophoblast indicate that P-glycoprotein transports substances across the uterine epithelium during early pregnancy and protects the conceptus from toxic substances during implantation and early embryogenesis. We hypothesized that P-glycoprotein is involved in the physiologic maintenance of early pregnancy and that P-glycoprotein dysregulation may be involved in early pregnancy pathologies. Read More

Acta Obstet Gynecol Scand 2019 10 22;98(10):1274-1281. Epub 2019 Jun 22.

The Center of Reproductive Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, China.

Introduction: Many studies have shown that multifetal reduction of high-order multiple pregnancies results in improved pregnancy outcomes. However, whether conducting elective fetal reduction from dichorionic twins after in vitro fertilization (IVF) is worthwhile remains controversial. This study aimed to determine whether elective fetal reduction of dichorionic twins after IVF and embryo transfer (IVF-ET) is associated with increased take-home baby rate. Read More

Am J Obstet Gynecol 2019 08 18;221(2):156.e1-156.e6. Epub 2019 Jun 18.

Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, CA; Kenneth J. Ryan Residency Training Program, University of California, San Francisco, San Francisco, CA; University of California, San Francisco Fellowship in Family Planning, San Francisco, CA.

Background: Only 64% of obstetrics and gynecology program directors report routine, scheduled training in abortion, despite the Accreditation Council for Graduate Medical Education's requirements for routine training. Most report that exposure to training is limited to specific clinical circumstances.

Objective: We sought to describe residency program directors' perspectives of support for and resistance to abortion training in residency training programs in the United States. Read More

J Gynecol Obstet Hum Reprod 2019 Oct 20;48(8):643-647. Epub 2019 Apr 20.

Département de Gynécologie, Obstétrique et Médecine de la Reproduction, CHU de Rennes, Hôpital sud, 16 Bd de Bulgarie, BP 90347, F-35 203, Rennes Cedex 2, France; Faculté de Médecine, Université de Rennes 1, 2 Avenue du Professeur Léon Bernard, 35000, Rennes, France. Electronic address:

Aim: To investigate the demographic, social, familial environmental and medical characteristics of women under 18 years having recourse to elective abortion (EA).

Methods: cross-sectional observational study from 01/02/2015 to 01/02/2016.

Results: 2626 EA were performed during study period and 210 (8%) minor women were identified. Read More

Am J Obstet Gynecol 2019 09 14;221(3):253.e1-253.e8. Epub 2019 Apr 14.

Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY.

Background: As compared with singleton gestations, twin pregnancies are associated with a significantly higher risk of preterm birth and maternal complications as well as fetal and neonatal morbidity and mortality. Multifetal pregnancy reduction is a technique developed in the 1980s to reduce the fetal number in higher-order multiple pregnancies to reduce the risk of adverse pregnancy outcomes, most importantly preterm birth.

Objective: The objective of the study was to compare pregnancy outcomes and loss rates in elective twin pregnancy reduction to ongoing twin gestations in a large contemporary cohort. Read More

Mult Scler 2019 Apr 10:1352458519843055. Epub 2019 Apr 10.

Department of Pediatrics, Rady Children's Hospital and University of California San Diego, La Jolla, CA, USA.

Background: Teriflunomide is contraindicated in pregnancy. Some pregnancies have occurred despite guidance to use effective contraception.

Objectives: To report outcomes of pregnancies occurring in teriflunomide clinical trials and the post-marketing setting. Read More

Fetal Pediatr Pathol 2019 Oct 7;38(5):376-386. Epub 2019 Apr 7.

Department of Obstetrics and Gynecology, Division of Perinatology, Hacettepe University Faculty of Medicine , Ankara , Turkey.

To evaluate the impact of type-1 diabetes mellitus (DM) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms on impaired placentation leading to early pregnancy loss. Miscarriage materials were obtained from eight pregnant women with type-1 DM without MTHFR polymorphism, eight with MTHFR polymorphisms without type-1 DM, and eight controls with neither DM nor MTHFR polymorphisms. Insulin-like growth factor-1 (IGF-1), leukemia inhibitory factor (LIF), and Beclin-1 expression were assessed to evaluate placentation. Read More

Reprod Fertil Dev 2019 May;31(6):1116-1126

Department of Obstetrics and Gynaecology, Affiliated Hospital of the Chinese People's Armed Police Force Logistics College, Tianjin 300162, China; and Tianjin Key Laboratory of Cardiovascular Remodelling and Target Organ Injury, Pingjin Hospital Heart Centre, Tianjin 300162, China; and Corresponding authors. Emails:

Activation of extracellular signal-regulated kinase (ERK) signalling, alteration of the uterine microenvironment and a reduction in human chorionic gonadotrophin production have been linked with fetal trisomy 16-induced early embryonic death (EED). However, the detailed biological mechanism of EED remains unclear. Using quantitative proteomics we successfully screened differentially expressed proteins in the villous tissues from patients with EED and fetal trisomy 16 (EEDT16), patients with EED but normal fetal chromosomes (EEDNC) and patients undergoing elective abortion with normal fetal chromosomes (EANC) as the reference group. Read More

Ultrasound Obstet Gynecol 2019 Dec 4;54(6):780-785. Epub 2019 Nov 4.

Department of Pediatrics, Division of Pediatric Cardiology, Columbia University Medical Center, New York-Presbyterian Hospital, New York, NY, USA.

Objectives: To describe fetal echocardiographic findings associated with lower urinary tract obstruction (LUTO) and to compare anatomic and hemodynamic measurements between fetuses with LUTO and gestational age (GA)-matched controls, with an emphasis on quantitative indices of diastolic function and cardiac output.

Methods: This was a retrospective cohort study of fetuses diagnosed with severe LUTO with giant bladder, which underwent at least one fetal echocardiogram at our center between January 2005 and June 2018. Fetuses with major congenital heart disease were excluded. Read More

Fetal Pediatr Pathol 2019 Jun 19;38(3):215-225. Epub 2019 Mar 19.

b Pathology & Laboratory Medicine , Rutgers-New Jersey Medical School , Newark , NJ , USA.

Objectives: Morbid adherence is a risk factor for retained placenta (RP). We encountered three cases of placenta increta presenting clinically as delayed postpartum hemorrhage.

Methods: This was a retrospective study of three cases of placenta increta presenting as RP. Read More

Lancet 2019 03 28;393(10178):1310-1318. Epub 2019 Feb 28.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China; The Key Laboratory of Reproductive Endocrinology of Ministry of Education, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China; Center for Reproductive Medicine, Ren Ji Hospital, Shanghai, China; School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Assisted Reproduction and Reproductive Genetics, Shanghai, China. Electronic address:

Background: Elective single embryo transfer (eSET) has been increasingly advocated, but concerns about the lower pregnancy rate after reducing the number of embryos transferred have encouraged transfer of multiple embryos. Extended embryo culture combined with electively freezing all embryos and undertaking a deferred frozen embryo transfer might increase pregnancy rate after eSET. We aimed to establish whether elective frozen single blastocyst transfer improved singleton livebirth rate compared with fresh single blastocyst transfer. Read More

Scand J Prim Health Care 2019 Mar 1;37(1):30-40. Epub 2019 Mar 1.

b PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy , University of Oslo , Oslo , Norway.

Objective: Hyperemesis gravidarum (HG) affects 0.3-3% of pregnant women and is a leading cause of hospitalization in early pregnancy. The aim of the study was to investigate women's treatment and management of HG, as well as the consequences of HG on women's daily life. Read More

Vaccine 2019 03 23;37(13):1792-1798. Epub 2019 Feb 23.

AP-HP, Cochin Hospital, Maison de Solenn, Paris, France; CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, 94805 Villejuif, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address:

Objective: Vaccination coverage against HPV in France is among the lowest in the industrialized world, although the public authorities have recently become aware of this issue. Few studies have looked at teenaged girls' representations of this vaccination, even though they are the most concerned by it. This qualitative study explored the experiences and representations of HPV vaccination by adolescent girls seeing doctors at least occasionally. Read More

J Emerg Med 2019 Mar 23;56(3):327-331. Epub 2019 Jan 23.

Department of Emergency Medicine, Medical University of South Carolina, Charleston, South Carolina.

Background: Vaginal bleeding is a common presenting complaint in the emergency department (ED); life-threatening hemorrhage is rare. Uterine artery pseudoaneurysm (UAP) is an uncommon but potentially life-threatening cause of vaginal bleeding that is most likely to present primarily to EDs, given its delayed postpartum or postoperative presentation.

Case Report: A 25-year-old female gravida two, para one, who was 19 days post dilation and evacuation for an elective termination of a pregnancy at 20 weeks, presented to the ED with profuse vaginal bleeding. Read More

Riv Psichiatr 2018 Nov-Dec;53(6):324-330

Faculty of Medicine and Psychology, Sapienza University of Rome, Italy.

Objective: The aim of this work was to identify risk predictors of a negative psychological outcome among personal, situational and systemic characteristics of women who choose to interrupt a pregnancy by elective (e.g., not feeling ready for giving birth) or therapeutic means (e. Read More

Case Rep Obstet Gynecol 2018 5;2018:9362962. Epub 2018 Dec 5.

Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Lincoln Medical and Mental Health Center, 234 East 149th Street, Bronx, New York 10451, USA.

Background: Throughout the world, intrauterine contraceptive devices (IUDs) are a frequently used, reversible, popular contraceptive method. They are usually placed without major complications. Uterine perforation is a rarely observed complication. Read More