Search Our Scientific Publications & Authors

Biol Trace Elem Res 2021 Jun 24. Epub 2021 Jun 24.

School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission, Xi'an, Shaanxi, China.

In this study, we aimed to explore the effectiveness of selenium on the chondrocyte glycoprotein glycosylation which plays important roles in the pathogenesis of Kashin-Beck disease (KBD). Cartilage samples were collected from KBD patients after total knee replacement surgery. Chondrocytes were cultured with sodium selenium. Read More

Int J Stroke 2020 Nov 25:1747493020974282. Epub 2020 Nov 25.

Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.

Background: Hospital-based studies have reported variable associations between outcome after spontaneous intracerebral hemorrhage and peri-hematomal edema volume.

Aims: In a community-based study, we aimed to investigate the existence, strength, direction, and independence of associations between intracerebral hemorrhage and peri-hematomal edema volumes on diagnostic brain CT and one-year functional outcome and long-term survival.

Methods: We identified all adults, resident in Lothian, diagnosed with first-ever, symptomatic spontaneous intracerebral hemorrhage between June 2010 and May 2013 in a community-based, prospective inception cohort study. Read More

Neuroscientist 2021 Jun 23:10738584211026527. Epub 2021 Jun 23.

Division of Neurology, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Pliny the Elder was a prolific Roman author, naturalist, and military leader. Yet, his impact on modern-day neuroscience, psychiatry, and neurology has been little explored. Here, we aimed to trace the origins of our current understanding of the brain in ancient Rome through Pliny and his work, . Read More

Br J Haematol 2021 Jun 22. Epub 2021 Jun 22.

National Coagulation Centre, St. James's Hospital, Dublin, Ireland.

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a novel entity that emerged in March 2021 following reports of unusual thrombosis after ChAdOx1 nCoV-19, (AstraZeneca) vaccination. Following the recognition of this syndrome, multiple consensus guidelines have been released to risk stratify patients presenting with possible symptoms after ChAdOx1 nCoV-19 vaccination. All guidelines rapidly identify VITT in patients with the complete triad of thrombocytopenia, thrombosis and elevated D-dimers after ChAdOx1 nCoV-19 vaccination. Read More

BMC Health Serv Res 2021 Jun 21;21(1):591. Epub 2021 Jun 21.

Department of Management Engineering, Politecnico di Milano, Milan, Italy.

Background: Family caregivers are key actors in the ageing society. They are mediators between practitioners and patients and usually provide also essential daily services for the elders. However, till now, few services have been deployed to help caregivers in their care tasks as in improving their mental health which can experience sever burden due to caregiving duties. Read More

J Gerontol A Biol Sci Med Sci 2021 Jun 21. Epub 2021 Jun 21.

GENUD (Growth, Exercise, NUtrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain.

Background: Physical fitness and body composition are important health indicators, nevertheless their combined pattern inter-relationships and their association with mortality are poorly investigated.

Methods: This longitudinal study is part of the Spanish EXERNET-Elder project. Person-months follow-up were calculated from the interview date, performed between June 2008 and November 2009, until date of death or censoring on March 2018 (whichever came first). Read More

J Elder Abuse Negl 2021 Jun 20;33(3):230-247. Epub 2021 Jun 20.

Department of Family and Consumer University of Utah, Salt Lake City, United States.

The relationship between aging and consumer fraud victimization is mixed in the literature. Most studies based on survey data have found older consumers less likely to be fraud victims, while a few studies have found older consumers more likely to be victimized, especially with certain fraud types. We developed a two-stage conceptual framework to differentiate fraud exposure from fraud victimization once exposed. Read More

Oral Dis 2021 Jun 19. Epub 2021 Jun 19.

Ege University, Faculty of Dentistry, Department of Periodontology, Turkey.

Ayşe Mayda born in İzmir (then known Smyrna) in September 1916, the elder daughter of a well to do family has been a leading figure and a true role model for Turkish women. She was only 18 years old, when having a surname became an obligation by law, and she chose Mayda as it was easy to pronounce and to recall both by Turkish and English speakers. She continues to be a living legend at the age of 105 years. Read More

J Health Psychol 2021 Jun 18:13591053211024726. Epub 2021 Jun 18.

Brown University, Providence, RI, USA.

Does an individual's risk profile predict their social distancing and mask wearing in the U.S. during the COVID-19 pandemic? Common sense and some health behavior theories suggest that as a perceived threat increases, an individual should be more likely to take preventive measures. Read More

Development 2021 Jun 18;148(12). Epub 2021 Jun 18.

Gladstone Institutes, San Francisco, CA 94158, USA.

Axial elongation of the neural tube is crucial during mammalian embryogenesis for anterior-posterior body axis establishment and subsequent spinal cord development, but these processes cannot be interrogated directly in humans as they occur post-implantation. Here, we report an organoid model of neural tube extension derived from human pluripotent stem cell (hPSC) aggregates that have been caudalized with Wnt agonism, enabling them to recapitulate aspects of the morphological and temporal gene expression patterns of neural tube development. Elongating organoids consist largely of neuroepithelial compartments and contain TBXT+SOX2+ neuro-mesodermal progenitors in addition to PAX6+NES+ neural progenitors. Read More

Commun Biol 2021 Jun 17;4(1):651. Epub 2021 Jun 17.

Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

Assessment of the endometrium often necessitates a biopsy, which currently involves an invasive, transcervical procedure. Here, we present an alternative technique based on deriving organoids from menstrual flow. We demonstrate that organoids can be derived from gland fragments recovered from menstrual flow. Read More

Nat Commun 2021 06 17;12(1):3679. Epub 2021 Jun 17.

Department of Physiology, Development and Neuroscience, Mammalian Embryo and Stem Cell Group, University of Cambridge, Cambridge, UK.

Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events underpinning this process are established in mice, they remain unknown in humans. Here we characterise key events of human embryo morphogenesis, in the period between implantation and gastrulation, using single-cell analyses and functional studies. Read More

Res Theory Nurs Pract 2021 Jun 17. Epub 2021 Jun 17.

Department of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.

Background And Purpose: Elder abuse, neglect, and exploitation are under-detected and under-reported. The purpose of this qualitative study was to describe out-ofhospital emergency care providers' experiences of identifying elder abuse.

Methods: Individual theme interviews were conducted with nine prehospital emergency care providers and three community paramedics in spring 2019. Read More

Environ Int 2021 Jun 15;155:106703. Epub 2021 Jun 15.

State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021, China. Electronic address:

The mammal gut is a rich reservoir of antibiotic resistance genes (ARGs), and the relationship between bacterial communities and ARGs has been widely studied. Despite ecological significance of microeukaryotes (fungi and protists), our understanding of their roles in the mammal gut microbiome and antibiotic resistome is still limited. Here, we used amplicon sequencing, metagenomic sequencing and high-throughput quantitative PCR to examine microbiomes and antibiotic resistomes of 41 giant panda fecal samples from individuals with different genders, ages, sampling sites and diet. Read More

J Ayub Med Coll Abbottabad 2021 Apr-Jun;33(2):217-221

Department of Urology and Kidney Transplant, Shifa International Hospital Islamabad, Pakistan.

Background: Urolithiasis is a prevailing ailment affecting all age groups across global population. In modern innovative industry endoscopic instruments alterations and miniaturization has simplified the interventional strategy for undertaking these procedures for renal stones. However, there has been paucity of studies regarding outcomes of Percutaneous Nephrolithotomy (PCNL) in elder age group. Read More

Gerodontology 2021 Jun 17. Epub 2021 Jun 17.

Department of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

Objective: This article describes a rare case of oral diverticulum.

Background: Diverticulum represents a sac-like protrusion of the gastrointestinal tract, commonly arising in the colon wall of elder individuals. Zenker's diverticulum can also occur in the pharyngeal mucosa. Read More

Indian J Public Health 2021 Apr-Jun;65(2):203-205

Assistant Professor, Department of Community Medicine, Indira Gandhi Medical College and Research Institute, Puducherry, India.

Road crash fatalities form leading cause of deaths in India. Streamlining road crash data systems are essential for building robust prevention strategies. This study explores epidemiological profile of fatal road crashes in a south Indian urban setting. Read More

J Elder Abuse Negl 2021 Jun 16;33(3):181-205. Epub 2021 Jun 16.

Psychology Department, Brock University, St. Catharines, Canada.

The present study assessed how accurate adults are at detecting fraudulent e-mail activity. A total of 100 younger (18-26 years) and 96 older adults (60-90 years) categorized a series of e-mails as legitimate or fraudulent phishing schemes and self-reported their fraud experiences. Younger and older adults did not differ in accuracy rates when categorizing the e-mails (72%), but older adults used a "high-suspicion" strategy where they were more likely to mislabel a legitimate e-mail as fraudulent compared to younger adults. Read More

Res Aging 2021 Jun 17:1640275211020795. Epub 2021 Jun 17.

Department of Gerontology and Gerontology Institute, John W. McCormack Graduate School of Policy & Global Studies, University of Massachusetts Boston, MA, USA.

The Affordable Care Act included the opportunity for states to increase spending on Medicaid home and community-based services (HCBS) for older adults and persons with disabilities through the Balancing Incentive Program (BIP). This study utilized comparative case studies to identify the factors that facilitated or impeded states' implementation of BIP. Findings indicate factors that facilitated the implementation of BIP were communication with the federal government and its contractor, merging BIP with existing HCBS programs, and enhanced federal revenue. Read More

Clin Nutr 2021 Apr 22;40(6):3852-3858. Epub 2021 Apr 22.

Department of Clinical Nutrition, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgen Str.5, 02781, Warsaw, Poland. Electronic address:

Background & Aims: Vitamin D impairs tumour-related transformation and supports the anticancer function of the immune system. Currently, there are no guidelines on vitamin D supplementation devoted solely to cancer patients. The primary objective of the study was to evaluate the frequency of vitamin D deficiency in Caucasian cancer patients and to characterize the clinical factors that predispose individuals to decreased vitamin D concentration. Read More

PLoS One 2021 15;16(6):e0252271. Epub 2021 Jun 15.

Division of Allergy and Immunology, General Hospital of the Medicine School of University of São Paulo, São Paulo, São Paulo, Brazil.

Coronavirus disease 2019 (CoViD-19), with the fatality rate in elder (60 years old or more) being much higher than young (60 years old or less) patients, was declared a pandemic by the World Health Organization on March 11, 2020. A mathematical model considering young and elder subpopulations under different fatality rates was formulated based on the natural history of CoViD-19 to study the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The model considered susceptible, exposed, asymptomatic, pre-symptomatic, mild CoViD-19, severe CoViD-19, and recovered compartments, besides compartments of isolated individuals and those who were caught by test. Read More

JMIR Aging 2021 Jun 15;4(2):e25671. Epub 2021 Jun 15.

School of Earth, Environment & Society, McMaster University, Hamilton, ON, Canada.

Background: Many informal caregivers of older adults have limited time because of the number of responsibilities that their caregiving role entails. This population often experiences high levels of burden due to the stressful nature of their work and are vulnerable to developing negative psychological health outcomes. Easily accessible and flexible knowledge interventions are needed to alleviate the burden and stress experienced by this group. Read More

Int Psychogeriatr 2021 Jun 15:1-11. Epub 2021 Jun 15.

School of Social Development and Public Policy, Fudan University, Shanghai, China.

Objectives: To explore the prevalence of EM in an older Chinese population and examine the mediating role of three psychosocial variables - psychological vulnerability, housework involvement, and financial independence - in the relationship between physical frailty and EM.

Design: Cross-sectional analysis.

Setting: The data source was the Third Survey on Chinese Women's Social Status (SCSSW), which is a nationwide decennial survey conducted in 2010. Read More

Clin Neurol Neurosurg 2021 Jun 8;207:106753. Epub 2021 Jun 8.

Non-Communicable Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Background: Hispanics are one of the largest and fastest-growing population in the United States. Having been reported as one of the high-risk ethnicities to develop Alzheimer's Disease (AD) makes elder Hispanics one of the significant groups of AD in the country, indicating a need to study the disparities in Hispanics vs. non-Hispanics patients. Read More

Res Nurs Health 2021 Jun 14. Epub 2021 Jun 14.

Department of Psychology, Academia Pedagogiki Specjalnej, University of Warsaw, Warsaw, Poland.

The purpose of this study was to test whether a syndrome model of elder psychopathology derived from collateral ratings, such as from spouses and adult children, in the United States would be generalizable in 11 other societies. Societies represented South America, Asia, and Europe. The Older Adult Behavior Checklist (OABCL) was completed by collateral informants for 6141 60- to 102-year-olds. Read More

J Med Internet Res 2021 Jun 14;23(6):e27076. Epub 2021 Jun 14.

Consumer Engagement and Codesign Research Hub, School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

Background: Breast cancer is the most common cancer among women globally. Recovery from breast cancer treatment can be mentally and physically challenging. SMS text message programs offer a novel way to provide health information and support, but few programs are co-designed with consumer representatives. Read More

JGH Open 2021 Jun 6;5(6):722-724. Epub 2021 May 6.

Division of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo Japan.

Recently, the use of immune checkpoint inhibitors (ICIs) with or without chemotherapeutic agents has been increasing in the treatment for advanced cancer. Here, we report the occurrence of liver failure after the use of pembrolizumab in an 82-year-old woman with metastatic liver disease derived from right advanced renal pelvis, ureteral cancer, and bladder cancer. She was successfully treated with 0. Read More

Front Psychol 2021 26;12:679541. Epub 2021 May 26.

Graduate School of Social Work, University of Denver, Denver, CO, United States.

As a global public health concern, elder abuse negatively affects health, psychosocial wellbeing, and mortality among elders. Research and practice efforts made to explore effective prevention and intervention strategies are growing. Despite the growing number of intervention studies on elder abuse, research synthesis on the empirical literature seems lacking. Read More

J Fam Violence 2021 Apr 5;36(3):389-398. Epub 2020 Mar 5.

The Kempe Center for the Prevention & Treatment of Child Abuse & Neglect, University of Colorado School of Medicine, 12401 E. 17th Ave. Mailstop B-215, Aurora, CO 80045, USA.

The experience of physicians and other health care providers in child abuse pediatrics in the last six decades includes successes and failures, which can offer critical insights to inform the growing field of health care providers focusing on elder abuse clinical practice and research. We identify and describe in detail relevant lessons learned, including balancing an urgent call to action with a need for robust evidence to support clinical conclusions. We discuss solutions to research challenges, including the lack of a uniform gold standard for abuse diagnosis and how to ethically recruit subjects who may have cognitive impairment and also be crime victims. Read More

J Interpers Violence 2021 Jun 12:8862605211022060. Epub 2021 Jun 12.

Riley Children's Hospital, Indianapolis, IN, USA.

Intimate partner violence (IPV) is a global public health issue and occurs in intimate relationships regardless of age or sexual orientation. Several studies, most of them relying on small-scale samples, have explored the prevalence and risk factors of IPV in older adults. Still, none have focused on the demographics and injury patterns in older adult victims. Read More