16,080 results match your criteria Elder Abuse


The influence of bed-sharing on infant physiology, breastfeeding and behaviour: A systematic review.

Sleep Med Rev 2018 Nov 16;43:106-117. Epub 2018 Nov 16.

Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, New Zealand. Electronic address:

This review aimed to better understand the underlying physiology of the risks and benefits of bed-sharing. Eight databases were searched using terms relating to adult-infant/baby, bed-sharing/co-sleeping combined with outcome terms for physiology, sleep, cardiovascular, respiratory, temperature and behaviour. Of 836 papers identified, 59 papers representing 48 cohorts met inclusion criteria. Read More

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November 2018
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'There is no point giving cash to women who don't spend it the way they are told to spend it' - Exploring women's agency over cash in a combined participatory women's groups and cash transfer programme to improve low birthweight in rural Nepal.

Soc Sci Med 2018 Dec 6;221:9-18. Epub 2018 Dec 6.

Institute for Global Health, University College London, 30 Guilford Street, WC1N 1EH, United Kingdom. Electronic address:

Cash transfer programmes form an integral part of nutrition, health, and social protection policies worldwide, but the mechanisms through which they achieve their health and nutritional impacts are incompletely understood. We present results from a process evaluation of a combined participatory women's groups and cash transfer programme to improve low birth weight in rural Nepal. We explored the ways in which context, implementation, and mechanism of the intervention affected beneficiary women's agency over cash transfers. Read More

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December 2018
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Influence of comorbidity on therapeutic decision making and impact on outcomes in patients with head and neck squamous cell cancers: Results from a prospective cohort study.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.

Background: High prevalence of comorbidity in head and neck squamous cell carcinoma (HNSCC) often lead to suboptimal treatment. The presence study aims to evaluate the presence of comorbidity, its impact on therapeutic decision making, treatment compliance, and overall survival in HNSCC.

Methods: Five hundred eighteen patients with nonmetastatic HNSCC, elder than 18 years of age, without any prior history of cancer or anticancer treatment in the last 5 years were evaluated using Adult Comorbidity Evaluation 27 (ACE 27) index. Read More

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December 2018

NRAS Q61R and BRAF G466A Mutations in Atypical Melanocytic Lesions Newly Arising in Advanced Melanoma Patients Treated with Vemurafenib.

J Cutan Pathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Background: BRAF inhibition has improved overall survival in patients with BRAF mutant melanoma but this is associated with a range of known and predictable cutaneous side effects, including squamous cell carcinomas associated with RAS mutations.

Methods: We identified three severely dysplastic nevi, one atypical intraepidermal melanocytic proliferation, and four melanoma in situ lesions, newly arising in four patients undergoing treatment with vemurafenib. To characterize mutations in these atypical melanocytic lesions, we used a custom iPlex panel detecting 74 mutations in 13 genes known to play a role in melanoma pathogenesis. Read More

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December 2018

Urinary disturbance in elder patients -Characteristic and problems based on the sex-.

Nihon Rinsho 2017 Apr;75(4):553-557

In the elderly person, various urinary symptoms are developed regardless of man and woman by a physical change with the aging. In elder men, we often recognize the progress of the urinary disturbance with the progress of benign prostatic hyperplasia (BPH). Based on the recent increase of prostate cancer patients, the number of elder patients treated with radi- cal prostatectomy or radiotherapy for prostate is increasing. Read More

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HPLC Fingerprint Combined with Quantitation of Phenolic Compounds and Chemometrics as an Efficient Strategy for Quality Consistency Evaluation of Sambucus nigra Berries.

Nat Prod Commun 2016 Oct;11(10):1449-1454

Sambucus nigra L. berries have been traditionally used as culinary and medicinal ingredients. To ensure the highest quality of elderberry plant products for consumers, the objective of this study was to develop a HPLC fingerprint procedure for quality consistency evaluation of S. Read More

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October 2016

[Cochlear implant for elder patients over 75 years old].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1477-1479

Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100032, China.

To evaluate the operation safety, hearing as well as speech results of cochlear implantation that were applied in patients over 75 years old. A series of patients who were diagnosed as severe to profound sensorineural hearing loss and received cochlear implantation were admitted. The clinical data and rehabilitation effects of the patients who were over 75 years old were summarized. Read More

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October 2018

Pseudorapidity Dependence of Particle Production and Elliptic Flow in Asymmetric Nuclear Collisions of p+Al, p+Au, d+Au, and ^{3}He+Au at sqrt[s_{NN}]=200  GeV.

Authors:
A Adare C Aidala N N Ajitanand Y Akiba M Alfred V Andrieux K Aoki N Apadula H Asano C Ayuso B Azmoun V Babintsev M Bai N S Bandara B Bannier K N Barish S Bathe A Bazilevsky M Beaumier S Beckman R Belmont A Berdnikov Y Berdnikov D S Blau M Boer J S Bok K Boyle M L Brooks J Bryslawskyj V Bumazhnov C Butler S Campbell V Canoa Roman R Cervantes C-H Chen C Y Chi M Chiu I J Choi J B Choi T Chujo Z Citron M Connors N Cronin M Csanád T Csörgő T W Danley A Datta M S Daugherity G David K DeBlasio K Dehmelt A Denisov A Deshpande E J Desmond A Dion P B Diss D Dixit J H Do A Drees K A Drees M Dumancic J M Durham A Durum T Elder A Enokizono H En'yo S Esumi B Fadem W Fan N Feege D E Fields M Finger M Finger S L Fokin J E Frantz A Franz A D Frawley Y Fukuda C Gal P Gallus P Garg H Ge F Giordano A Glenn Y Goto N Grau S V Greene M Grosse Perdekamp T Gunji H Guragain T Hachiya J S Haggerty K I Hahn H Hamagaki H F Hamilton S Y Han J Hanks S Hasegawa T O S Haseler K Hashimoto X He T K Hemmick J C Hill K Hill A Hodges R S Hollis K Homma B Hong T Hoshino N Hotvedt J Huang S Huang K Imai J Imrek M Inaba A Iordanova D Isenhower Y Ito D Ivanishchev B V Jacak M Jezghani Z Ji J Jia X Jiang B M Johnson V Jorjadze D Jouan D S Jumper S Kanda J H Kang D Kapukchyan S Karthas D Kawall A V Kazantsev J A Key V Khachatryan A Khanzadeev C Kim D J Kim E-J Kim G W Kim M Kim M H Kim B Kimelman D Kincses E Kistenev R Kitamura J Klatsky D Kleinjan P Kline T Koblesky B Komkov D Kotov S Kudo B Kurgyis K Kurita M Kurosawa Y Kwon R Lacey J G Lajoie E O Lallow A Lebedev S Lee S H Lee M J Leitch Y H Leung N A Lewis X Li X Li S H Lim L D Liu M X Liu V-R Loggins S Lökös K Lovasz D Lynch T Majoros Y I Makdisi M Makek M Malaev A Manion V I Manko E Mannel H Masuda M McCumber P L McGaughey D McGlinchey C McKinney A Meles M Mendoza W J Metzger A C Mignerey D E Mihalik A Milov D K Mishra J T Mitchell I Mitrankov G Mitsuka S Miyasaka S Mizuno A K Mohanty P Montuenga T Moon D P Morrison S I Morrow T V Moukhanova T Murakami J Murata A Mwai K Nagai K Nagashima T Nagashima J L Nagle M I Nagy I Nakagawa H Nakagomi K Nakano C Nattrass P K Netrakanti T Niida S Nishimura R Nishitani R Nouicer T Novák N Novitzky R Novotny A S Nyanin E O'Brien C A Ogilvie J D Orjuela Koop J D Osborn A Oskarsson G J Ottino K Ozawa R Pak V Pantuev V Papavassiliou J S Park S Park S F Pate M Patel J-C Peng W Peng D V Perepelitsa G D N Perera D Yu Peressounko C E PerezLara J Perry R Petti M Phipps C Pinkenburg R Pinson R P Pisani A Pun M L Purschke P V Radzevich J Rak B J Ramson I Ravinovich K F Read D Reynolds V Riabov Y Riabov D Richford T Rinn S D Rolnick M Rosati Z Rowan J G Rubin J Runchey A S Safonov B Sahlmueller N Saito T Sakaguchi H Sako V Samsonov M Sarsour K Sato S Sato B Schaefer B K Schmoll K Sedgwick R Seidl A Sen R Seto P Sett A Sexton D Sharma I Shein T-A Shibata K Shigaki M Shimomura T Shioya P Shukla A Sickles C L Silva D Silvermyr B K Singh C P Singh V Singh M J Skoby M Slunečka K L Smith M Snowball R A Soltz W E Sondheim S P Sorensen I V Sourikova P W Stankus M Stepanov S P Stoll T Sugitate A Sukhanov T Sumita J Sun Z Sun S Suzuki S Syed J Sziklai A Takeda A Taketani K Tanida M J Tannenbaum S Tarafdar A Taranenko G Tarnai R Tieulent A Timilsina T Todoroki M Tomášek C L Towell R Towell R S Towell I Tserruya Y Ueda B Ujvari H W van Hecke S Vazquez-Carson J Velkovska M Virius V Vrba N Vukman X R Wang Z Wang Y Watanabe Y S Watanabe F Wei A S White C P Wong C L Woody M Wysocki B Xia C Xu Q Xu L Xue S Yalcin Y L Yamaguchi H Yamamoto A Yanovich P Yin J H Yoo I Yoon H Yu I E Yushmanov W A Zajc A Zelenski S Zharko S Zhou L Zou

Phys Rev Lett 2018 Nov;121(22):222301

University of California-Riverside, Riverside, California 92521, USA.

Asymmetric nuclear collisions of p+Al, p+Au, d+Au, and ^{3}He+Au at sqrt[s_{NN}]=200  GeV provide an excellent laboratory for understanding particle production, as well as exploring interactions among these particles after their initial creation in the collision. We present measurements of charged hadron production dN_{ch}/dη in all such collision systems over a broad pseudorapidity range and as a function of collision multiplicity. A simple wounded quark model is remarkably successful at describing the full data set. Read More

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November 2018

Family caregivers of elderly with dementia Relationship between religiosity, resilience, quality of life and burden.

Dement Neuropsychol 2018 Oct-Dec;12(4):408-414

Professor of the School of Psychology, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil.

There are gaps in knowledge regarding how the family caregiver deals with the burden of caring for elderly people with dementia.

Objective: To evaluate the family caregivers' perception of quality of life (QoL), burden, resilience and religiosity and relate them with cognitive aspects and occurrence of neuropsychiatric symptoms of elderly with dementia.

Methods: Data from the QoL-AD scale, caregivers' version, burden interview, resilience scale, Beck depression inventory and PDUREL of 50 family caregivers were correlated with disability assessment for dementia, neuropsychiatric inventory and clinical aspects of 50 elderly with dementia. Read More

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December 2018
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Common mental disorder among family carers of demented older people in Brazil.

Dement Neuropsychol 2018 Oct-Dec;12(4):402-407

MD,PhD, Department of Internal Medicine, São Paulo State University (UNESP), Botucatu Medical School, Botucatu, SP, Brazil.

Objective: Population aging is a global phenomenon associated with a rising prevalence of chronic degenerative diseases such as dementia. Dementia poses a challenge not only for patients but also their family caregivers who, in exercising this role, are at higher risk of mental illness. The present study investigated the prevalence of common mental disorders (CMD) in family caregivers of demented elderly seen at a geriatric outpatient clinic of a Brazilian teaching hospital. Read More

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December 2018

Diabetic and Elder Patients Experience Superior Cardiovascular Benefits After Gastric Bypass Induced Weight Loss.

Front Endocrinol (Lausanne) 2018 28;9:718. Epub 2018 Nov 28.

Endocrine, Cardiovascular and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine, University of Porto, Porto, Portugal.

Obesity and obesity related co-morbidities are well-recognized risks for cardiovascular (CV) disease and mortality. Weight loss improves CV risk factors and the efficacy of bariatric surgery in decreasing CV mortality is now well-established. Our aim was to assess CV risk progression and occurrence of CV events in a cohort of patients that underwent Roux-en-Y gastric bypass (RYGB) for obesity treatment in a single academic public center. Read More

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November 2018

Paying your respects: Transgender women and detransitioning after death.

Death Stud 2018 Dec 12:1-7. Epub 2018 Dec 12.

a Department of History , Susquehanna University , Selinsgrove , Pennsylvania , USA.

This paper asks how do the deaths and the postmortem detransitioning (the verbal, visual, and material rejection of a person's gender identity) of transgender women impact trans activism? After analyzing the case studies of Jennifer Gable and Leelah Alcorn, I outline how the contentious memorialization of transgender women and the disenfranchized grief of survivors influence trans activism. I conclude that activism is characterized by respecting the wishes of the deceased, by preventing the violence which transgender women experience, by advocating for trans elder care, by educating about end-of-life issues, and by lobbying for laws that protect transgender men and women after death. Read More

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December 2018

Development and assessment of the content validity of the professional good practices scale in nursing homes.

Int Psychogeriatr 2018 Dec 7:1-5. Epub 2018 Dec 7.

Department of Psychology and Pedagogy, School of Medicine, Universidad San Pablo-CEU,CEU Universities,Madrid,Spain.

ABSTRACTRecent approaches in the care of older people have led to a greater emphasis on good practices to prevent elder abuse. The instruments assessing good practices are very limited, and those focused on elder abuse have rarely considered subtle forms, especially in institutional settings. The aim of this study was to develop and assess the content validity of a good practices scale for professionals working in nursing homes. Read More

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December 2018

Squamous cell carcinoma of the tongue in patients older than 45 years.

Braz Oral Res 2018 Dec 6;32:e123. Epub 2018 Dec 6.

Hospital General de México "Eduardo Liceaga", Department of Pathology, México City, México.

This study aims to evaluate the clinicopathological features, TNM status, AJCC staging and behavior of squamous cell carcinoma of the tongue (SCCT) in patients older than 45 years. The files of the Department of Pathology of the Hospital General de México were reviewed and all cases of SCCT in patients older than 45 years were selected. Clinicopathological features, treatment, follow-up, microscopic diagnosis, and IJCC and TNM staging were retrieved. Read More

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December 2018

Characterization of Campylobacter jejuni, Campylobacter upsaliensis, and a novel Campylobacter sp. in a captive non-human primate zoological collection.

J Med Primatol 2018 Dec 9. Epub 2018 Dec 9.

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Background: The aim of this study was to longitudinally investigate the prevalence and characterization of Campylobacter spp. from non-human primates primate (NHP) with a history of endemic diarrhea housed at Como Park Zoo.

Methods: Fecal samples from 33 symptom-free NHP belonging to eight different species were collected weekly for 9 weeks. Read More

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December 2018
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Association of Informal Caregiver Distress with Health Outcomes of Community-Dwelling Dementia Care Recipients: A Systematic Review.

J Am Geriatr Soc 2018 Dec 10. Epub 2018 Dec 10.

Division of Geriatric Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Background: Most dementia care occurs in the community with support from informal caregivers who are often distressed. Dementia caregiver distress is known to be hazardous to the caregiver's health, but the impact on the dementia care recipient is not well known.

Methods: We searched the Medline, Embase, PsycINFO, CINAHL, and Cochrane databases from inception until June 2017 for studies investigating the association of informal caregiver distress with health outcomes of community-dwelling dementia care recipients. Read More

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December 2018

Prevalence and Predictors of Abuse in Elderly Patients with Depression at a Tertiary Care Centre in Saurashtra, India.

Indian J Psychol Med 2018 Nov-Dec;40(6):528-533

Department of Psychiatry, M. P. Shah Government Medical College, Jamnagar, Gujarat, India.

Context: Elder abuse has devastating consequences such as poor quality of life, psychological distress and loss of property and security. Abuse of elderly patients with depression has not been adequately researched in India.

Aims: To explore the prevalence and predictors of abuse and its relation to various sociodemographic variables in elderly patients with depression. Read More

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December 2018

Mental Health Implications of Elder Abuse and Domestic Violence.

Indian J Psychol Med 2018 Nov-Dec;40(6):507-508

Department of Psychiatry, Government Medical College, Kozhikode, Kerala, India.

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December 2018

Microwave plasmonic mixer in a transparent fibre-wireless link.

Nat Photonics 2018 Dec 29;12(12):749-753. Epub 2018 Oct 29.

ETH Zurich, Institute of Electromagnetic Fields (IEF), 8092 Zurich, Switzerland.

To cope with the high bandwidth requirements of wireless applications1, carrier frequencies are shifting towards the millimetre-wave and terahertz bands2-5. Conversely, data is normally transported to remote wireless antennas by optical fibres. Therefore, full transparency and flexibility to switch between optical and wireless domains would be desirable6,7. Read More

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December 2018
2 Reads

Valve sparing aortic root replacement in elderly patients with annulo-aortic ectasia.

Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiovascular Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address:

Background: Reporting early and midterm outcomes of elderly patients who underwent valve-sparing aortic root replacement (VSRR) compared to younger patients and those with Bentall procedure.

Methods: From October 1999 to October 2017, 73 patients aged ≥65 years who underwent VSRR procedure was assigned as group S. Two hundred thirty-two VSSR patients who were between 15 and 64 years old were assigned as group Y. Read More

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December 2018

A trans-ethnic Mendelian randomization study identifies causality of obesity on risk of psoriasis.

J Invest Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita 565-0871, Japan. Electronic address:

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December 2018
7.216 Impact Factor

Neutrophil Extracellular Traps Induce Human Th17 Cells: Effect of Psoriasis-Associated TRAF3IP2 Genotype.

J Invest Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Dermatology, University of Michigan, Ann Arbor, MI, United States; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, United States. Electronic address:

Psoriasis lesions are rich in IL-17-producing T-cells as well as neutrophils, which release webs of DNA-protein complexes known as neutrophil extracellular traps (NETs). Because we and others have observed increased NETosis in psoriatic lesions, we hypothesized that NETs contribute to increased Th17 cells in psoriasis. After stimulating peripheral blood mononuclear cells (PBMCs) with anti-CD3/CD28 beads for 7 days, we found significantly higher percentages of CD3+CD4+IL-17+ (Th17) cells in the presence vs. Read More

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December 2018
7.216 Impact Factor

Effect of a short multicomponent exercise intervention focused on muscle power in frail and pre frail elderly: A pilot trial.

Exp Gerontol 2018 Dec 4;115:114-121. Epub 2018 Dec 4.

CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain; Hospital Virgen del Valle, Complejo Hospitalario de Toledo, Toledo, Spain. Electronic address:

Objectives: The aim was to establish whether a short supervised facility-based exercise program improved frailty, physical function and performance in comparison with usual care treatment.

Methods: This was a quasi-experimental, non-randomized controlled intervention study in frail (2.75 ± 1. Read More

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December 2018

Incorporating indigenous knowledge in health services: a consumer partnership framework.

Public Health 2018 Oct 24. Epub 2018 Oct 24.

Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia; Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia; Top-End Renal Service, Darwin, NT, Australia. Electronic address:

Objectives: Healthcare policy and planning should be informed by a partnership between healthcare services and healthcare users. This is critical for people who access care frequently such as indigenous Australians who have a high burden of chronic kidney disease. This study aimed to explore the most appropriate ways of enhancing services by incorporating renal patients' expectations and satisfaction of care in Australia's Northern Territory. Read More

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October 2018
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Profiling the N-glycan composition of IgG with Lectins and Capillary Nanogel Electrophoresis.

Anal Chem 2018 Dec 9. Epub 2018 Dec 9.

Glycosylated human IgG contains fucosylated biantennary N-glycans with different modifications including N-acetylglucosamine that bisects the mannose core. Although only a limited number of IgG N-glycan structures are possible, human IgG N-glycans are predominantly biantennary and fucosylated and contained varying levels of α2-6 linked sialic acid, galactose, and bisected N-acetylglucosamine. Monitoring the relative abundance of bisecting N-acetylglucosamine is relevant to physiological processes. Read More

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December 2018

[2018 ESC/ESH Guidelines for the Management of Arterial Hypertension: What's New with Regard to Our Older People?]

Dtsch Med Wochenschr 2018 Dec 3;143(24):1745-1748. Epub 2018 Dec 3.

Klinik für Allgemeine Innere Medizin und Geriatrie, Angiologie, Diabetologie, Endokrinologie, Nephrologie, Krankenhaus Barmherzige Brüder Regensburg.

In the "2018 ESC/ESH Guidelines for the management of arterial hypertension" there are new blood pressure (BP) recommendations with regard to older patients based on randomized controlled trials and well-conducted meta-analyses performed during the last years.It is recommended to base the diagnosis of hypertension on repeated office BP measurements under standardized conditions and in older people in out-of-office BP measurement with ABPM and/or HBPM if logistically and economically feasible. Furthermore lying and standing BP measurements should also be considered in subsequent visits in older people to exclude orthostatic hypotension. Read More

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December 2018

In-hospital outcomes of transcatheter mitral valve repair with Mitraclip in patients with pulmonary hypertension: Insights from the National Inpatient Sample.

Catheter Cardiovasc Interv 2018 Dec 2. Epub 2018 Dec 2.

Department of Cardiovascular Medicine, Wayne State University/Detroit Medical Center, Detroit, Michigan.

Background: Periprocedural outcomes of transcatheter mitral valve repair (TMVR) with Mitraclip in patients with pulmonary hypertension (PH) are not well studied.

Methods: Patients who underwent TMVR with Mitraclip between 2011 and 2015 were identified using the National Inpatient Sample (NIS). All missing variables were excluded from the analysis and therefore, complete case analysis was performed. Read More

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December 2018
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The safety and efficacy of percutaneous vertebroplasty for patients over 90 years old.

Jpn J Radiol 2018 Dec 1. Epub 2018 Dec 1.

Department of Radiology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Objective: To retrospectively analyze the safety and efficacy of percutaneous vertebroplasty (PVP) for patients aged 90 or over.

Materials And Methods: We analyzed 130 consecutive patients with osteoporotic vertebral fractures who underwent a first-time PVP between May 2015 and September 2017 at our institution. We divided them into the elder patient group aged 90 years or over (n = 21) and the younger patient group under 90 years (n = 109). Read More

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December 2018
1 Read

Comparison of group motivational interviewing and multimedia education on elderly lifestyle.

J Educ Health Promot 2018 29;7:133. Epub 2018 Oct 29.

Department of Nursing, Health Research Center of Pregnancy, Zahedan University of Medical Sciences, Zahedan, Iran.

Background: Many of the problems caused by aging can be delayed and the health of the elderly maintained by improving and applying a healthy lifestyle during old age. Therefore, the researcher has designed and implemented a study aimed "compare the impact of group motivational interviews with multimedia education on improving lifestyle in the elderly."

Methods: This study is triple blind before and after clinical trial was performed on three groups of thirty ( = 90) of the elderly with mean age 63. Read More

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October 2018

International Board Members of the American Journal of Ophthalmology.

Am J Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Medical University of Gdańsk, Poland.

This year marks the 100th anniversary of the "modern" American Journal of Ophthalmology (AJO). International influence was present since the beginnings of the journal, and AJO had several foreign editorial board members and collaborators. Within the article we present sketches of the deceased international board members of the AJO, particularly of Sir Stewart Duke-Elder, Pierre Amalric, Joaquin Barraquer and Yasuo Tano. Read More

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November 2018
1 Read

Tracking the dynamic functional connectivity structure of the human brain across the adult lifespan.

Hum Brain Mapp 2018 Dec 4. Epub 2018 Dec 4.

Key Laboratory of Cognition and Personality (Ministry of Education), Chongqing, China.

The transition from early adulthood to the elder is marked by functional and structural brain transformations. Many previous studies examined the correlation between the functional connectivity (FC) and aging using resting-state fMRI. Results showed that the changes in FC are linked to aging as well as the cognitive ability changes. Read More

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December 2018
3 Reads

[Percutaneous transforaminal endoscopic discectomy via lateral position assisted with local anesthesia for lumbar disc herniation in elder with systemic diseases].

Zhongguo Gu Shang 2018 Nov;31(11):1065-1068

Department of Spinal Surgery, Mingzhou Hospital of Zhejiang University, Ningbo 315100, Zhejiang, China;

Objective: To explore the clinical effect of percutaneous transforaminal endoscopic discectomy via lateral position assisted with local anesthesia for lumbar disc herniation in elder with systemic diseases.

Methods: The clinical data of 44 elder patients with lumbar disc herniation and systemic diseases treated from June 2013 to June 2017 were retrospectively analyzed. Including 26 males and 18 females, aged 70 to 86 years old with an average of(77. Read More

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November 2018

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Authors:

BJS Open 2018 Dec 27;2(6):400-410. Epub 2018 Jul 27.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery.

Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. Read More

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December 2018
7 Reads

A mouse model for the study of transplanted bone marrow mesenchymal stem cell survival and proliferation in lumbar spinal fusion.

Eur Spine J 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, The Johns Hopkins University School of Medicine, 1550 Orleans St, Rm 2M-51, Baltimore, MD, 21287, USA.

Purpose: Bone marrow aspirate has been successfully used alongside a variety of grafting materials to clinically augment spinal fusion. However, little is known about the fate of these transplanted cells. Herein, we develop a novel murine model for the in vivo monitoring of implanted bone marrow cells (BMCs) following spinal fusion. Read More

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December 2018

Metabolic syndrome and cardiometabolic risk factors among indigenous Malaysians.

Public Health 2018 Nov 30. Epub 2018 Nov 30.

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Sunway City, Selangor, Malaysia. Electronic address:

Objectives: This study was undertaken to investigate the occurrence of metabolic syndrome (MetS) and cardiovascular disease (CVD) risk in Orang Asli (OA), the indigenous people of Peninsular Malaysia. OA consist of Negrito, Proto-Malay, and Senoi groups who collectively comprise only 0.76% of the population of Peninsular Malaysia. Read More

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November 2018

Cortical covariance networks in ageing: Cross-sectional data from the Irish Longitudinal Study on Ageing (TILDA).

Neuropsychologia 2018 Nov 27. Epub 2018 Nov 27.

St. James' Hospital, Dublin 8, Ireland; Centre for Advanced Medical Imaging (CAMI), St. James' Hospital, Dublin 8, Ireland.

Ageing is associated with widespread alterations to the brain's anatomy and to attendant cortical networks. Yet, few studies to date have indexed anatomical covariance network differences within the age distribution of older adulthood, despite known phenotypic variation. Here, we explored cortical anatomical covariance networks in middle and older age cross-sectionally, using a large sample of community-dwelling older adults from the Irish Longitudinal Study on Ageing (TILDA). Read More

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November 2018

Comparison of 12-hour and 24-hour oximetry recordings in preterm infants.

J Paediatr Child Health 2018 Nov 30. Epub 2018 Nov 30.

Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.

Aim: To compare the overnight 12-hour oximetry component of 24-hour oximetry recordings with the complete 24-h recording in terms of cardiorespiratory status data in preterm infants.

Methods: Preterm infants from the Wellington neonatal intensive care unit underwent a 24-h pulse oximetry recording immediately prior to discharge home. Each recording was edited to resemble a 12-h overnight recording and compared to the full 24-h recording. Read More

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November 2018

Postpartum anticoagulation in women with mechanical heart valves.

Int J Womens Health 2018 25;10:663-670. Epub 2018 Oct 25.

Department of Obstetrics, Gynecology and Reproductive Sciences, Section of Maternal-Fetal Medicine, Yale University School of Medicine, New Haven, CT, USA,

Background: Women with mechanical heart valves (MHV) requiring anticoagulation (AC) are at high risk for hemorrhagic complications. Despite guidelines to manage antenatal and peripartum AC, there are few evidence-based recommendations to guide the initiation of postpartum AC. We reviewed our institutional experience of pregnant women with MHV to lay the groundwork for recommendations of immediate postpartum AC therapy. Read More

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October 2018
5 Reads

Use of Sialic Acid as a Complementary Method in the Cytological Diagnosis: Preliminary Study.

J Cytol 2018 Oct-Dec;35(4):242-246

Department of Clinical Biochemistry, Laboratory of Cytology, INFIBIOC, University of Buenos Aires, Buenos Aires, Argentina.

Introduction: Cellular morphology does not allow, in many cases, to safely establish a diagnosis of malignancy or benignity. Sialic acid is found in the membranes of well-differentiated mature cells, normally located in the alpha-2,3 position. During tumor progression, changes occur in glycosylation of proteins and lipids, including alterations in the sialylation patterns of tumor cells. Read More

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December 2018

Alström Syndrome Presenting as Isolated Dilated Cardiomyopathy.

Indian J Pediatr 2018 Nov 28. Epub 2018 Nov 28.

Department of Medical Genetics, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Cardiomyopathy is an etiologically heterogeneous condition, and non-syndromic as well as syndromic genetic causes are identified in a significant proportion of cases without a known acquired cause. The present report describes a 2-mo-old boy who presented initially with a referral diagnosis of isolated dilated cardiomyopathy, without any associated dysmorphism or malformations, and with history of similar cardiac disease and early infantile death in an elder male sibling. Next generation sequencing (NGS) based multigene panel testing of the cardiomyopathy-associated genes was done which revealed the diagnosis of Alström syndrome, based on which appropriate management and surveillance could be planned for the child and accurate genetic counseling could be provided to the parents. Read More

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November 2018
1 Read

Aging-related changes of EEG synchronization during a visual working memory task.

Cogn Neurodyn 2018 Dec 8;12(6):561-568. Epub 2018 Sep 8.

1The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 Shaanxi Province People's Republic of China.

Differences of EEG synchronization between normal old and young people during a working memory (WM) task were investigated. The synchronization likelihood (SL) is a novel method to assessed synchronization in multivariate time series for non-stationary systems. To evaluate this method to study the mechanisms of WM, we calculated the SL values in brain electrical activity for both resting state and task state. Read More

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December 2018
4 Reads

Age of Migration and the Incidence of Cognitive Impairment: A Cohort Study of Elder Mexican-Americans.

Innov Aging 2017 Nov 2;1(3):igx037. Epub 2018 Feb 2.

University of Texas Medical Branch, Sealy Center on Aging, Galveston.

Background And Objectives: To explore nativity and age of migration differentials in the incidence of cognitive impairment among older Mexican-Americans.

Research Design And Methods: We employ maximum-likelihood discrete time hazard models to estimate risk ratios of cognitive impairment in a sample of 2,708 Mexican-Americans 65 and older who were cognitively healthy at baseline over a follow-up period of up to 20 years.

Results: Late-life immigrant women have a 46% higher risk of cognitive impairment compared to U. Read More

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November 2017
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Innovative Models for High-Risk Patients Use Care Coordination and Palliative Supports to Reduce End-of-life Utilization and Spending.

Innov Aging 2017 Sep 20;1(2):igx021. Epub 2017 Nov 20.

NORC at the University of Chicago, Health Care Department, Bethesda, Maryland.

Background And Objectives: Care coordination and palliative care supports are associated with reduced anxiety, fewer hospital admissions, and improved quality of life for patients and their families. Early palliative care can result in savings in the end-of-life period, but there is limited evidence that larger-scale models can improve both utilization and the cost of care. Three models that received Health Care Innovation Awards from the Centers for Medicare & Medicaid Services aimed to improve quality of care and reduce cost through the use of innovative care coordination models. Read More

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September 2017
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Two male siblings with a novel mutation presenting with different findings of IPEX syndrome.

JMM Case Rep 2018 Oct 15;5(10):e005167. Epub 2018 Oct 15.

Department of Pediatric Immunology, Ege University Faculty of Medicine, Izmir, Turkey.

Introduction: LPS-responsive beige-like anchor (LRBA) protein deficiency is a disease of immune dysregulation with autoimmunity affecting various systems.

Case Presentation: Two male siblings with a novel mutation had different primary findings at admission: the younger sibling had chronic early-onset diarrhoea and the elder one had autoimmune haemolytic anaemia. During long-term follow-up for IPEX phenotype, both developed hypogammaglobulinaemia, enteropathy and lung involvement. Read More

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October 2018
3 Reads

[Accidental intoxication by outdoor and garden plants : Data from two German poison centres].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2018 Nov 26. Epub 2018 Nov 26.

Abteilung Exposition, Bundesinstitut für Risikobewertung, Berlin, Deutschland.

Background And Objectives: Accidental exposure of children to plants occurs often and results in numerous calls to poison centres. The aim of this study was to identify outdoor plants that led to moderate or severe poisoning after accidental exposure and to identify patterns of paediatric plant exposures.

Materials And Methods: Human exposure data on accidental exposures provided by two German poison centres were retrospectively evaluated regarding the number and the routes of exposure. Read More

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November 2018
2 Reads

Association between liver enzymes and bone mineral density in Koreans: a cross-sectional study.

BMC Musculoskelet Disord 2018 Nov 24;19(1):410. Epub 2018 Nov 24.

Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, 538 Gangnam-daero, Gangnam-gu, Seoul, Republic of Korea.

Background: Osteoporosis is a major health concern for both men and women, and associated fractures incur substantial economic burden. While there are a multitude of studies on bone mineral density (BMD) and liver diseases, not many studies have assessed the association between liver enzyme levels and BMD in homogeneous populations.

Methods: The current study investigated the association between serum liver enzyme levels and BMD at various sites in Koreans. Read More

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November 2018
4 Reads

P38 Mitogen-activated Protein Kinase and Parkinson's Disease.

Transl Neurosci 2018 12;9:147-153. Epub 2018 Nov 12.

School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.

Parkinson's disease, the second major neurodegenerative disease, has created a great impact on the elder people. Although the mechanisms underlying Parkinson's disease are not fully understood, considerable evidence suggests that neuro-inflammation, oxidative stress, mitochondrial dysfunction, cell proliferation, differentiation and apoptosis are involved in the disease. p38MAPK, an important member of the mitogen-activated protein family, controls several important functions in the cell, suggesting a potential pathogenic role in PD. Read More

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November 2018
4 Reads

Antibacterial, antifungal and enzyme inhibitory effects of selected plants from Turkey.

Pak J Pharm Sci 2018 11 26. Epub 2018 Nov 26.

Faculty of Vocational Education, Department of Biology, Hacettepe University, Ankara, Turkey.

In this study, antibacterial, antifungal, antihyaluronidase, anticollagenase and antielastase activity of Hypericum bithynicum, Malva neglecta, Morus alba, Rubus discolor, Sambucus ebulus and Smilax excelsa were investigated. Methanol extracts of M. neglecta and R. Read More

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November 2018
4 Reads

Sambucus ebulus extract stimulates cellular responses in cutaneous leishmaniasis.

Parasite Immunol 2018 Nov 25:e12605. Epub 2018 Nov 25.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

This is the first study aiming to determine the therapeutic effects of the S. ebulus aquatic extract as an antileishmanial herbal drug and evaluate the immune responses in L. major infected BALB/c mice. Read More

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November 2018
1 Read

Does the Evidence Support Adolescent Varicocelectomy?

Authors:
Jack Elder

Eur Urol 2018 Nov 21. Epub 2018 Nov 21.

Division of Pediatric Urology, Urology Department, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

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November 2018