1,343 results match your criteria Elastosis Perforans Serpiginosum


Pushing and loss of elastic fibers are highly specific for melanoma and rare in melanocytic nevi.

Arch Dermatol Res 2018 Dec 13. Epub 2018 Dec 13.

Dermatology Department, Inselspital Bern University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.

The histopathological differentiation of melanocytic nevi from malignant melanoma (MM) is based on well-known criteria, and is straightforward in the vast majority of cases. However, there are few cases of melanocytic lesions (ML), the diagnosis of which is very challenging or even impossible. Here we have studied several morphological characteristics with particular focus on elastic fibers (EF) to identify features, helpful for the distinction between nevi and MM. Read More

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December 2018
1 Read

In vivo multiphoton microscopy imaging of melasma.

Pigment Cell Melanoma Res 2018 Dec 1. Epub 2018 Dec 1.

Unilever R&D, 40 Merritt Blvd, Trumbull, CT, 06611.

Melasma is a skin disorder characterized by hyperpigmented patches due to increased melanin production and deposition. In this pilot study we evaluate the potential of multiphoton microscopy (MPM) to characterize non-invasively the melanin content, location, and distribution in melasma and assess the elastosis severity. We employed a clinical MPM tomograph to image in-vivo morphological features in melasma lesions and adjacent normal skin in 12 patients. Read More

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December 2018

Histopathological comparison of lesional and perilesional skin in melasma: A cross-sectional analysis.

Indian J Dermatol Venereol Leprol 2018 Dec 5. Epub 2018 Dec 5.

Consultant Dermatologist and Epidemiologist, Mumbai, Maharashtra, India.

Background: Melasma is a common acquired hyperpigmentary disorder of the sun exposed skin, especially the face. The pathogenesis is unclear but interplay between genetic factors, hormones and ultraviolet radiation is important. We have evaluated the histological characteristics of melasma and compared the findings with adjacent normal skin. Read More

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December 2018
3 Reads

Platelet-rich Plasma for Skin Rejuvenation and Treatment of Actinic Elastosis in the Lower Eyelid Area.

Cureus 2018 Jul 18;10(7):e2999. Epub 2018 Jul 18.

Plastic Surgery, Waldkrankenhaus Bonn, Bonn, DEU.

Background Treatment of the lower eyelid region to rejuvenate the skin or treat actinic elastosis often proves difficult. Established treatment options, such as hyaluronic acid injections, botulinum toxin injections, microneedling, skin resurfacing (microdermabrasion, chemical peel (exfoliation), laser treatment), as well as blepharoplasties and autologous fat transfers, can be associated with significant risks and increased patient burden. Furthermore, they may not be effective for treating the signs of skin aging or actinic elastosis, including dark rings under the eyes, a lack of volume and cutis laxa. Read More

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July 2018
5 Reads

A case of unilateral inflamed plaques with comedones of the face.

Dermatol Pract Concept 2018 Oct 31;8(4):292-294. Epub 2018 Oct 31.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.

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October 2018
3 Reads

Melasma: Updates and Perspectives.

Exp Dermatol 2018 Nov 13. Epub 2018 Nov 13.

Seoul National University, College of Medicine, Seoul National University Bundang Hospital, Gyeonggi, Korea.

Management of melasma is highly challenging due to inconsistent treatment results and frequent relapses. However, recent studies revealed that melasma may not only be a disease of melanocytes, but also a photoaging skin disorder. Herein, we attempt to validate that melasma is indeed a photoaging disorder by presenting the histopathologic findings of melasma: solar elastosis, altered basement membrane, increased vascularization, and increased mast cell count. Read More

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November 2018
1 Read

Hybrid palliation as a bridge to biventricular repair in critical aortic stenosis with coarctation.

Ann Thorac Surg 2018 Nov 8. Epub 2018 Nov 8.

Division of Congenital Heart Surgery, Department of Surgery, Medical College of Wisconsin; Herma Heart Institute, Children's Hospital of Wisconsin.

Optimal management- balloon dilation versus surgical valvotomy- of neonatal critical aortic stenosis (AS) remains controversial. We describe a term neonate with critical AS and coarctation, severe left ventricular (LV) dysfunction with endocardial fibro-elastosis palliated with surgical valvotomy and hybrid as a bridge to early biventricular repair. Initial repair consisted of commissurotomy to create bicuspid morphology with placement of bilateral pulmonary artery bands and maintenance of ductal patency with prostaglandin. Read More

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November 2018
6 Reads

Lesions Mimicking Melanoma at Dermoscopy Confirmed Basal Cell Carcinoma: Evaluation with Reflectance Confocal Microscopy.

Dermatology 2019 7;235(1):35-44. Epub 2018 Nov 7.

Dermatology Unit, Department of Surgical, Medical, Dental and Morphological Sciences with Interest Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena,

Background: Atypical basal cell carcinoma (BCC), characterized by equivocal dermoscopic features typical of malignant melanoma (MM), can be difficult to diagnose. Reflectance confocal microscopy (RCM) enables in vivo imaging at nearly histological resolution.

Objectives: To evaluate with RCM atypical melanocytic lesions identified in dermoscopy, according to common RCM criteria for the differential diagnosis of BCC, and to identify representative RCM parameters for superficial (sBCCs) and nonsuperficial (nsBCCs) basal cell carcinomas (BCCs). Read More

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November 2018
5 Reads
1.680 Impact Factor

Dermal Lesions and Skin Cancer in Patients with Inflammatory Bowel Disease Receiving Immunosuppressive Therapy

Asian Pac J Cancer Prev 2018 Oct 26;19(10):2845-2851. Epub 2018 Oct 26.

Department of Cardiology, University Hospital of Ioannina, Greece. Email:

Background: Anti-TNFa medications represent the first effective biologic therapy for IBD that has largely revolutionized treatment. The aim of this study was to quantify the risk of MM and other skin cancers among patients from Northern Greece area with IBD who take immunosuppressive or biologic anti-TNF medications. Methods: The current study was conducted during a 3-year period (2014-2016). Read More

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October 2018
5 Reads

Melanoma coexisting with solar elastosis: a potential pitfall in the differential diagnosis between nevus and melanoma.

Hum Pathol 2018 Oct 22. Epub 2018 Oct 22.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Melanomas, like non-melanoma skin cancers, are known to be causally related to sun exposure. It is therefore not surprising to see benign nevi and melanomas in a background of solar damage, which at times may complicate their distinction. Due to their long-standing nature, nevi often occur before the development of solar elastosis, and as such, are intimately associated with the solar elastosis. Read More

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October 2018
1 Read
2.770 Impact Factor

Claudin-1 expression decreases with increasing pathological grade in actinic keratosis and may be a marker of high-risk actinic keratosis.

Clin Exp Dermatol 2018 Oct 12. Epub 2018 Oct 12.

Department of Dermatology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.

Background: Actinic keratosis (AK) is a common sun-induced skin disorder that can progress to invasive squamous cell carcinoma. However, there is still no reliable method to predict high-risk AK.

Aim: To identify markers that reflect the biological behaviour of AK and to understand the pathogenesis of AK. Read More

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October 2018
1 Read

[Multifocal chalazodermic amyloidosis: The concept of immunoglobulinemic elastopathy].

Ann Dermatol Venereol 2018 Dec 9;145(12):777-784. Epub 2018 Oct 9.

Clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1 place de l'hôpital, 67091, Strasbourg, France.

Introduction: Impairment of dermal elastic tissue occurs in different entities associated with immunoglobulins or immunoglobulin-derived protein-secreting clonal plasma cell proliferations, such as amyloid elastosis, anetodermic nodular amyloidosis or monoclonal gammopathy-associated cutis laxa. We report a case of cutaneous immunoglobulinemic amyloidosis revealed by a unique chalazodermic presentation and we review elastic tissue impairment in patients with monoclonal gammopathies.

Observation: A 67-year-old woman consulted for non-infiltrated anetodermic lesions on the upper left quadrant of her abdomen present for ten years. Read More

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December 2018
6 Reads

Dermatological aspects of the S2k guidelines on Down syndrome in childhood and adolescence.

J Dtsch Dermatol Ges 2018 Oct;16(10):1289-1295

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetology, Saarland University Medical Center, Homburg, Germany.

With an incidence of 1 in 700 births, Down syndrome (DS) is not an uncommon condition. It is associated with various disorders of different organ systems. Serious disorders include cardiac defects and leukemia. Read More

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October 2018
3 Reads

Dermatologische Aspekte aus der S2k-Leitlinie zum Down-Syndrom im Kindes- und Jugendalter.

J Dtsch Dermatol Ges 2018 Oct;16(10):1289-1296

Universität des Saarlandes, Kliniken für Kinder- und Jugendmedizin, Sektion Pädiatrische Endokrinologie und Diabetologie, Homburg.

Das Down-Syndrom (DS) ist mit einer Inzidenz von 1 : 700 aller Geburten nicht selten und mit diversen Erkrankungen unterschiedlicher Organsysteme assoziiert. Zu den schwerwiegenden Erkrankungen zählen Herzfehler und Leukämie. Letztere zeigt sich im Neugeborenenalter und geht nicht immer in eine klassische myeloische Leukämie über (transiente myeloproliferative Erkrankung). Read More

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October 2018
3 Reads

Collagenous and elastotic marginal plaques of the hand: A potential clue to the diagnosis of alkaptonuria.

J Cutan Pathol 2018 Oct 7. Epub 2018 Oct 7.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

Collagenous and elastotic marginal plaques of the hand (CEMPH) is a rare, chronic keratoderma characterized by hyperkeratotic linear plaques located along the radial and ulnar aspects of the hands bilaterally. As an isolated finding, CEMPH occurs secondarily to chronic trauma and photodamage. Herein, CEMPH is described as a manifestation of alkaptonuria (AKU). Read More

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October 2018
2 Reads

Keratotic papules in an annular arrangement.

JAAD Case Rep 2018 Oct 29;4(9):851-853. Epub 2018 Sep 29.

University of Texas Health at San Antonio, San Antonio, Texas.

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October 2018
3 Reads

The role of TERT promoter mutations in differentiating recurrent nevi from recurrent melanomas: a retrospective, case-control study.

J Am Acad Dermatol 2018 Oct 1. Epub 2018 Oct 1.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:

Background: Repigmentation at previous biopsy sites pose a significant diagnostic dilemma given clinical and histologic similarities between recurrent nevi and locally recurrent melanoma. While common in melanoma, the role of TERT promoter mutations (TPMs) in recurrent nevi is unknown.

Objective: We investigated the role of TPMs in recurrent nevi and whether the presence of hotspot TPM distinguishes recurrent nevi from locally recurrent melanoma. Read More

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October 2018
3 Reads

Intratunical Injection of Stromal vascular fraction prevents Fibrosis in a Rat Model of Peyronie's Disease.

BJU Int 2018 Sep 29. Epub 2018 Sep 29.

Laboratory for Experimental Urology, Organ systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium.

Objective: Previous studies have shown that the injection of adipose tissue-derived stem cells (ADSCs) into the tunica albuginea (TA) during the active phase of the Peyronie's disease (PD) prevents the development of fibrosis and elastosis in the TA and corpus cavernosum The aim of this study was to investigate whether local injection of autologous adipose stromal vascular fraction (SVF) can prevent the development of fibrosis and elastosis in the TA using a rat model of acute phase of the Peyronie's disease (PD) METHODS: A total of 24 male 12-wk-old Sprague-Dawley rats were divided in three equal groups: sham, PD without treatment (TGFB) and PD treated with SVF (SVF) 1 day after disease induction. Sham rats underwent 2 injections of vehicle into the TA one day apart. TGFB rats underwent TGF- β1 injection and injection of vehicle one day later. Read More

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September 2018
7 Reads

Resurfacing with Ablation of Periorbital Skin Technique: Indications, Efficacy, Safety, and 3D Assessment from a Pilot Study.

Photomed Laser Surg 2018 Oct 20;36(10):541-547. Epub 2018 Sep 20.

8 Istituto di diagnosi e terapie dermatologiche ed estetiche (ISDET) , Bari, Italy .

Objectives And Background: Nowadays, several approaches for skin rejuvenation of the lower eyelid are available. We present a new technique of resurfacing with ablation of periorbital skin (RAP) performed in a single session.

Methods: This is a retrospective study involving 20 patients showing skin elastosis with or without evidence of the nasojugal fold and atrophic and dyschromic skin or needing a combined approach of transconjuntival lower blepharoplasty for fat bag removal. Read More

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October 2018
5 Reads
1.580 Impact Factor

Airway-Centered Pleuroparenchymal Fibroelastosis Associated with Non-Necrotizing Granulomas: A Rare New Entity.

Pathobiology 2018 17;85(5-6):276-279. Epub 2018 Sep 17.

Azienda USL Romagna, Department of Thoracic Diseases, Ospedale GB Morgagni, Forlì, Italy.

Pleuroparenchymal fibroelastosis is a rare form of upper-lobe-dominant progressive pulmonary fibrosis characterized histologically by visceral pleural thickening with collagenous fibrosis, subpleural elastosis, and intra-alveolar collagenous fibrosis. It was first described 25 years ago by Amitani et al. This report firstly describes a new variant or rare phenotype of PPFE with airway involvement, minimal pleuroparenchymal connections, and non-necrotizing granulomas. Read More

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September 2018
1 Read

Elastin molecular aging promotes MDA-MB-231 breast cancer cell invasiveness.

FEBS Open Bio 2018 Sep 2;8(9):1395-1404. Epub 2018 Aug 2.

UMR CNRS/URCA 7369 SFR CAP Santé Faculty of Sciences University of Reims Champagne-Ardenne France.

Elastin is a long-lived extracellular matrix protein responsible for the structural integrity and function of tissues. Breast cancer elastosis is a complex phenomenon resulting in both the deposition of elastotic masses and the local production of elastin fragments. In invasive human breast cancers, an increase in elastosis is correlated with severity of the disease and age of the patient. Read More

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September 2018

A risk model for the prediction of skin tears in aged care residents: A prospective cohort study.

Int Wound J 2018 Sep 2. Epub 2018 Sep 2.

School of Public Health, Curtin University, Perth, Western Australia, Australia.

The objective of this study was to construct a predictive model to identify aged care residents at risk of future skin tears. Extensive data about individual characteristics, skin characteristics, and skin properties were gathered from 173 participants at baseline and at 6 months. A predictive model, developed using multivariable logistic regression, identified five variables that significantly predicted the risk of skin tear at 6 months. Read More

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September 2018
7 Reads

Elastosis perforans serpiginosa: causes and associated disorders.

Eur J Dermatol 2018 Aug;28(4):476-481

Department of Surgical, Microsurgical and Medical Sciences, Dermatology, University of Sassari, Italy.

Background: Elastosis perforans serpiginosa (EPS) is an uncommon cutaneous disorder classified under perforating diseases (PD); a group of dermatoses with transepidermal extrusion of collagen or elastic tissue. Three EPS subtypes have been reported that differ according to aetiology, associated diseases, and histopathological features. Herein, we report a systematic review of the literature, as well as a case of a 41-year-old woman with Wilson disease treated with penicillamine (PCM), who developed EPS after 11 years of drug intake. Read More

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August 2018
1 Read

Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing.

Nutr Res 2018 Sep 9;57:97-108. Epub 2018 Jun 9.

Research and Development Department, MINERVA Research Labs, 1-6 Yarmouth Place, London, W1J 7BU, UK. Electronic address:

Aging is a multifactorial and natural process that causes physiological changes in organs, tissues and cells over time. In the skin and cartilage, aging leads to a decrease in the synthesis and changes in the arrangement of proteoglycans and collagen, in addition to the loss of glycosaminoglycans, which are responsible for the integrity and health of these tissues. We hypothesized that daily oral supplementation with a liquid nutraceutical containing hydrolyzed fish collagen, vitamins, antioxidants and other active ingredients could improve skin texture and elasticity, and in addition have a protective effect on joint health. Read More

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September 2018
9 Reads

Sequential facial skin rejuvenation with intense pulsed light and non-ablative fractionated laser resurfacing in fitzpatrick skin type II-IV patients: A prospective multicenter analysis.

Lasers Surg Med 2018 Aug 8. Epub 2018 Aug 8.

Dermatological Practice-Laser Center, Konz, Germany.

Background: While skin aging is triggered by multiple factors and typically presents with multiple manifestations, conventional treatment regimens deploy a single treatment modality. Typical approaches exploit ablative techniques, which involve considerable patient discomfort and downtime and can induce adverse events. Non-ablative fractionated laser (NAFL) resurfacing promotes neocollagenesis, with significantly fewer complications and discomfort. Read More

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August 2018
10 Reads

Acquired elastotic hemangioma, a little-known entity: report of a case with 15 years of evolution.

An Bras Dermatol 2018 Jul-Aug;93(4):559-561

Dermatology Service, Hospital do Servidor Público Estadual de São Paulo, São Paulo (SP), Brazil.

Acquired elastotic hemangioma is a hemangioma variant first described in 2002. It is characterized by being a benign, solitary, slow-growing lesion, that appears in adulthood and is associated with solar exposure. It is a rare hemangioma variant with few cases reported in the literature. Read More

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September 2018
1 Read

Atrophic and Annular Scarring Alopecia of the Scalp as a Finding in Underlying Systemic Sarcoidosis.

Acta Dermatovenerol Croat 2017 Dec;25(4):298-299

Dario Didona, MD, Prima Divisione Dermatologica , Istituto Dermopatico dell'Immacolata-IRCCS, Via dei Mont di Creta 104 , 00167 Rome, Italy;

Cutaneous sarcoidosis is not an uncommon disorder, and the skin can be the sole manifestation in about 10% of patients. However, when the involved anatomical area of the cutaneous sarcoidosis is the scalp and it presents as a scarring alopecia, there is an increased risk of a systemic disease (1,2). A 79-year-old Caucasian male patient presented to our Institute with annular and painless plaques of the scalp, with variable diameter, showing a reddish and yellowish color (Figure 1, a). Read More

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December 2017
11 Reads

Understanding Solar Skin Elastosis-Cause and Treatment.

J Cosmet Sci 2018 May/Jun;69(3):175-185

BASF Beauty Care Solutions, Lyon 69007, France (S.P., N.B., C.N., V.D., V.A.).

Photoageing, also called actinic ageing, is the main cause of prematurely aged skin. Our expertise in elastic fibers has led us to discover a process triggered in response to ultraviolet (UV) light and which upsets the balance of elastin fibers: there is too much elastin and insufficient lysyl oxidase (LOXL1) enzyme to form functional elastic fibers. This imbalance then leads to an accumulation of nonfunctional elastin, which forms aggregates. Read More

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September 2018
13 Reads

Nevus-Associated Melanoma: Patient Phenotype and Potential Biological Implications.

J Invest Dermatol 2018 Aug;138(8):1696-1698

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Italy; Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy.

Pandeya et al. report that nevus-associated melanoma is associated with a specific phenotype, namely, young age, high number of nevi, non-brown eye color and slight dermal elastosis. Potential implications regarding differences between nevus-associated melanomas and de novo melanomas are discussed. Read More

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August 2018
2 Reads

Linearized solar elastosis of the legs: A novel presentation and review of the literature.

J Cutan Pathol 2018 Nov 15;45(11):855-857. Epub 2018 Aug 15.

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.

There exists a spectrum of solar elastotic variants based on the clinical and histopathologic findings. We present here a peculiar case of solar elastosis that is unusual in its anatomic location, relative lack of background actinic damage, and pattern of linearization. Its presentation suggests that other factors in addition to ultraviolet radiation may play a role in the pathogenesis of solar elastosis. Read More

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November 2018
5 Reads

Reflectance confocal microscopy features of melanomas on the body and non-glabrous chronically sun-damaged skin.

J Cutan Pathol 2018 Oct 31;45(10):754-759. Epub 2018 Jul 31.

Sheba Medical Center and Sackler Faculty of Medicine, Medical Screening Institute, Tel Aviv University, Tel Aviv, Israel.

Background: Melanoma remains a challenge to diagnose, especially when appearing on the background of chronically sun-damaged skin (CSDS). Our goal was to identify and quantify the reflectance confocal microscopy (RCM) features of melanoma on non-facial CSDS.

Methods: Included lesions were biopsy-proven melanomas, from anatomic sites other than the face, neck, scalp and acral skin, with histopathologic finding of solar elastosis in the underlying dermis. Read More

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October 2018
17 Reads

Physical properties of the photodamaged human skin dermis: Rougher collagen surface and stiffer/harder mechanical properties.

Exp Dermatol 2018 Jun 29. Epub 2018 Jun 29.

Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan.

Fragmentation of collagen fibrils and aberrant elastic material (solar elastosis) in the dermal extracellular matrix (ECM) is among the most prominent features of photodamaged human skin. These alterations impair the structural integrity and create a dermal microenvironment prone to skin disorders. The objective of this study was to determine the physical properties (surface roughness, stiffness and hardness) of the dermal ECM in photodamaged and subject-matched sun-protected human skin. Read More

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June 2018
3 Reads

Dual wavelength treatment protocol with a picosecond laser for the reduction of facial wrinkles.

Authors:
Michael H Gold

J Cosmet Laser Ther 2018 Jun 8:1-5. Epub 2018 Jun 8.

a Tennessee Clinical Research Center, Gold Skin Care Center , Nashville , TN, USA.

Introduction: The potential of a dual wavelength picosecond laser, as a new modality for treating photoaged skin, was investigated in this clinical study.

Material And Methods: Subjects with bilateral mild-to-moderate facial wrinkling received four picosecond laser treatments, at 3-8 weeks apart, with a double-pass of both 532-nm and 1064-nm split-beam handpieces. Blinded evaluation of clinical photography, by two independent physicians, using the Fitzpatrick Elastosis Scale, was performed at 12 weeks after the fourth treatment. Read More

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June 2018
1 Read

Extracellular matrix and fibroblast injection produces pterygium-like lesion in rabbits.

Biol Res 2018 Jun 5;51(1):15. Epub 2018 Jun 5.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, 64710, Monterrey, NL, Mexico.

Background: Translational research to develop pharmaceutical and surgical treatments for pterygium requires a reliable and easy to produce animal model. Extracellular matrix and fibroblast are important components of pterygium. The aim of this study was to analyze the effect of the subconjunctival injection of fibroblast cells (NIH3T3 cell line) and exogenous extracellular matrix in rabbits in producing a pterygium-like lesion. Read More

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June 2018
12 Reads

Case of late-onset focal dermal elastosis.

J Dermatol 2018 Dec 31;45(12):e339-e340. Epub 2018 May 31.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

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December 2018
1 Read

Acquired Brachial Cutaneous Dyschromatosis in a Middle Aged Male.

Ann Dermatol 2018 Jun 23;30(3):342-344. Epub 2018 Apr 23.

Department of Dermatology, Ewha Womans University School of Medicine, Seoul, Korea.

Acquired brachial cutaneous dyschromatosis (ABCD) is an acquired disorder of pigmentary change that presents as chronic, asymptomatic, geographic-shaped, gray-brown patches, consisting of mixed hyper and hypopigmented macules on the dorsal aspect of the forearms. We report a case of a 40-year-old male who presented with asymptomatic, multiple brown-colored macules on the outer aspects of both arms. He had no history of hypertension and had never taken angiotensin converting enzyme inhibitors. Read More

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June 2018
13 Reads

Histopathological Parameters in Pterygia and Significant Clinical Correlations.

J Ophthalmic Vis Res 2018 Apr-Jun;13(2):110-118

Department of Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Purpose: To evaluate the clinical and histopathological parameters of pterygium to determine significant correlations between parameters that can affect management strategies.

Methods: A total of 47 pterygia were clinically examined and excised for histopathological evaluation of epithelial and stromal changes. Some samples were immunostained with P53 (a protein of 53 kilodalton used as dysplastic epithelial marker), CD20 (CD/cluster of differentiation, are group of surface receptors providing targets for cellular immunophenotyping, CD20 as a B lymphocyte marker), CD 3 (as T lymphocyte marker) or vascular endothelial growth factor (VEGF/as vascular marker). Read More

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May 2018
3 Reads

Perforating Calcific Elastosis: Revisiting a Rare Entity.

Indian J Dermatol 2018 Mar-Apr;63(2):186-188

Department of Dermatology, ESI-PGIMSR and ESIC Medical College, Kolkata, West Bengal, India. E-mail:

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Correlations between histopathologic and dermoscopic findings in Korean actinic keratosis.

Microsc Res Tech 2018 Apr 20. Epub 2018 Apr 20.

Department of Dermatology, Korea University College of Medicine, Seoul, Korea.

Skin biopsy for AK diagnosis is usually performed on only a limited part of the whole lesion. Therefore, a clinical diagnosis is important. According to a study, there is no significant correlation between histopathological and clinical classification system. Read More

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April 2018
5 Reads

Image Gallery: Linear focal elastosis mimicking striae distensae.

Br J Dermatol 2018 Apr;178(4):e278

Department of Dermatology and Allergy, Technical University of Munich, Biedersteiner Straße 29, 80802, Munich, Germany.

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April 2018
1 Read

Nail dryer devices: a measured spectral irradiance and labelling review.

Photochem Photobiol Sci 2018 May;17(5):592-598

Electrical Safety Area of DEKRA Testing and Certification, S.A.U., Málaga, Spain.

The popularity of nail beauty has increased during the last few years in Spain, as well as in other countries. Nowadays there are a large number of nail dryer devices in the market with ultraviolet (UV) fluorescent lamps, light emitting diodes (LED) or a combination of both. The different spectral emissions of each individual nail dryer device require particular nail polishes, which are polymerized by specific wavelengths and a controlled exposure time to achieve the desired results. Read More

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May 2018
16 Reads

Photodynamic therapy for aesthetic-cosmetic indications.

G Ital Dermatol Venereol 2018 Dec 29;153(6):817-826. Epub 2018 Mar 29.

Cologne Dermatology Center, Cologne, Germany -

Photodynamic therapy (PDT) is a well-established, non-invasive treatment for a variety of dermatologic disorders, including actinic keratosis. Furthermore, PDT results in marked improvements in the signs of skin aging, although currently there are no standardized guidelines for PDT in skin rejuvenation. Two types of PDT are available: conventional-PDT (c-PDT) and the newly introduced daylight-PDT (DL-PDT). Read More

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December 2018
2 Reads

Telomerase reverse transcriptase promoter mutations and solar elastosis in cutaneous melanoma.

Melanoma Res 2018 Oct;28(5):398-409

Institute of Pathology, Aarhus University Hospital, Aarhus C, Denmark.

The aims of this study were to assess the prognostic potential of solar elastosis grading and telomerase reverse transcriptase (TERT) promoter mutations (TERTp) in melanoma and to evaluate whether an association between solar elastosis and TERTp exists. Solar elastosis in the dermis was evaluated in hematoxylin and eosin-stained whole slides from 486 malignant melanomas. Pyrosequencing was used to detect TERTp in 189 samples. Read More

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October 2018
3 Reads

Pleuroparenchymal fibroelastosis presenting with pneumothorax.

SAGE Open Med Case Rep 2018 8;6:2050313X18762853. Epub 2018 Mar 8.

Division of Molecular Pathology, Pathology and Laboratory Medicine Department, Taipei Veterans General Hospital, Taipei, Taiwan.

A 47-year-old woman presented with spontaneous right side pneumothorax. Image studies showed consolidations and reticular opacities involving the pleural and subpleural regions of bilateral lungs. Wedge biopsy specimens of right upper, middle and lower lobes showed fibrosis of the visceral pleura and subpleural area in all three lobes, more significant in the upper lobe. Read More

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Factors Related to Nevus-Associated Cutaneous Melanoma: A Case-Case Study.

J Invest Dermatol 2018 Aug 7;138(8):1816-1824. Epub 2018 Mar 7.

Population Health Department, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. Electronic address:

A proportion of cutaneous melanomas display neval remnants on histologic examination. Converging lines of epidemiologic and molecular evidence suggest that melanomas arising from nevus precursors differ from melanomas arising de novo. In a large, population-based study comprising 636 cutaneous melanomas subjected to dermatopathology review, we explored the molecular, host, and environmental factors associated with the presence of neval remnants. Read More

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August 2018
6 Reads

Acquired Elastotic Hemangioma: Case Series and Comprehensive Literature Review.

Cureus 2017 Dec 28;9(12):e1994. Epub 2017 Dec 28.

Department of Dermatology, University of California, San Diego.

Background Acquired elastotic hemangioma is a benign vascular proliferation that typically presents as an asymptomatic red plaque on a sun-exposed site of an adult. Material and Methods The PubMed database was used to search the following words: acquired, angioma, arm, basal, carcinoma, cell, elastosis, elastotic, exposed, forearm, hemangioma, solar, sun, and vascular. The relevant papers and reference cited generated by the search were reviewed. Read More

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December 2017

A single-center clinical trial to evaluate the efficacy of a tripeptide/hexapeptide antiaging regimen.

J Cosmet Dermatol 2018 Mar 4. Epub 2018 Mar 4.

Compass Dermatopathology, San Diego, CA, USA.

Introduction: An antiaging regimen that aids in clearing the matrix of waste products and stimulating neocollagenesis and neoelastogenesis was tested among a group of subjects over the course of 12 weeks to assess its efficacy in women with mild to moderate wrinkles and skin sagging on the face.

Materials And Methods: The efficacy of the product regimen was tested in 22 subjects using investigator clinical grading measurements, raking light imaging, 3D imaging, biopsies, and self-assessment questionnaires at baseline and weeks 4, 8, and 12.

Results: Clinical grading indicated that use of the antiaging regimen for 12 weeks produced a statistically significant improvement in scores for all evaluated parameters; the raking light image analysis demonstrated a statistically significant improvement in values for length, width, and area of wrinkles when compared with baseline values as did 3D imaging. Read More

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March 2018
4 Reads
1.000 Impact Factor

Focal linear elastosis in a patient with joint hypermobility syndrome.

Dermatol Online J 2018 Jan 15;24(1). Epub 2018 Jan 15.

Walter Reed National Military Medical Center, Bethesda, Maryland.

Focal linear elastosis (FLE) is a benign skin findingcharacterized by hypertrophic linear plaques withabnormal elastic fibers on histology. We present aunique case in which focal linear elastosis occurredin the setting of joint hypermobility syndrome(JHS). Our patient, a 20-year-old man with a medicalhistory significant for symptoms consistent with JHS,had been followed by the rheumatology clinic formany months. Read More

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January 2018
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Mechanisms of Glaucoma in Exfoliation Syndrome.

Authors:
Mineo Ozaki

J Glaucoma 2018 Jul;27 Suppl 1:S83-S86

Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Ozaki Eye Hospital, Hyuga, Miyazaki, Japan.

The most important characteristic of exfoliation syndrome (XFS) is that it involves a greater risk of developing glaucoma. In comparison with other forms of open-angle glaucoma, exfoliation glaucoma is more resistant to medical therapy and progresses faster. Possible pathologic mechanisms of glaucoma development in XFS comprise: (1) elevated intraocular pressure (IOP) caused by functional impairment of aqueous humor outflow due to deposition of exfoliation material in the trabecular meshwork and trabecular cell dysfunction, (2) XFS-associated connective tissue elastosis leading to structural and functional alterations of the lamina cribrosa which increases the vulnerability toward elevated IOP and development of glaucomatous optic neuropathy, (3) elevated IOP due to closure of the anterior chamber angle accompanied by forward displacement of the crystalline lens due to zonular weakness, (4) presumable primary functional impairment of retinal ganglion cells. Read More

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