1,359 results match your criteria Elastosis Perforans Serpiginosum


Clinical purpura and elastosis and their correlation with skin tears in an aged population.

Arch Dermatol Res 2019 Feb 20. Epub 2019 Feb 20.

School of Public Health, Curtin University, Kent St, Bentley, WA, 6102, Australia.

The previous research reported the results of a prospect cohort study that used logistic regression analysis to construct a risk prediction model for skin tears in individuals aged over 65 years. The model identified three baseline individual characteristics (male gender, history of STs, and history of falls) and two baseline skin manifestations (purpura and elastosis) that predicted the risk of dorsal forearm skin tears. This paper outlines the relationships between baseline skin manifestations and the risk of skin tears. Read More

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http://link.springer.com/10.1007/s00403-019-01899-9
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http://dx.doi.org/10.1007/s00403-019-01899-9DOI Listing
February 2019
1 Read

Mutation Status in Primary, Recurrent, and Metastatic Malignant Melanoma and Its Relation to Histopathological Parameters.

Dermatol Pract Concept 2019 Jan 31;9(1):54-62. Epub 2019 Jan 31.

Second Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece.

Background: mutations are a common finding in malignant melanoma (MM). Nevertheless, apart from their significance as a therapeutic target in advanced melanoma, their prognostic value is still debated.

Objective: To assess mutation status in primary, recurrent, or metastatic MM and its correlations with histopathological findings. Read More

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http://dx.doi.org/10.5826/dpc.0901a13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368075PMC
January 2019

D-penicillamine-induced pseudo-pseudoxanthoma elasticum and extensive elastosis perforans serpiginosa with excellent response to acitretin.

Ann Saudi Med 2019 Jan-Feb;39(1):56-60

Dr. Muzamil Amin Chisti, MBC 46 Department of Dermatology,, King Faisal Specialist Hospital and Research Centre,, PO Box 3354, Riyadh 11211, Saudi Arabia, T: +966114424608, ORCID: http:// orcid.org/0000-0002-6877-2715.

D-penicillamine (DPA)-induced pseudo-pseudoxanthoma elasticum (PXE) and elastosis perforans serpiginosa (EPS) has been reported in the past, but most of the treatment modalities used before have a sub.optimal response. We report a case of DPA-induced pseudo-PXE with extensive EPS who had an excellent rapid response to acitretin. Read More

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http://dx.doi.org/10.5144/0256.4947.2019.56DOI Listing
February 2019

Synthesis and structure-activity relationship of elastase inhibiting novel ethylated thiazole-triazole acetamide hybrids: Mechanistic insights through kinetics and computational contemplations.

Bioorg Chem 2019 Jan 28;86:197-209. Epub 2019 Jan 28.

Department of Chemistry, Government College University, Lahore 54000, Pakistan. Electronic address:

Keeping in mind the pharmacological importance of 2-aminothiazole and 1,2,4-triazole heterocyclic moieties, a series of novel ethylated bi-heterocyclic acetamide hybrids, 9a-p, was synthesized in a multi-step protocol. The structures of newly synthesized compounds were characterized by H NMR, C NMR, IR and EI-MS spectral studies. The inhibitory effects of these bi-heterocyclic acetamides (9a-n) were evaluated against elastase and all these molecules were identified as potent inhibitors relative to the standard used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00452068183127
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http://dx.doi.org/10.1016/j.bioorg.2019.01.040DOI Listing
January 2019
3 Reads

Histopathologic variables differentially affect melanoma survival by age at diagnosis.

Pigment Cell Melanoma Res 2019 Jan 31. Epub 2019 Jan 31.

School of Medicine, University of New Mexico, Albuquerque, New Mexico.

We evaluated clinical, phenotypic, behavioral, and histopathologic variables in relationship to melanoma-specific survival by age at diagnosis among 650 population-based melanoma patients in Connecticut, with 20 years of follow-up. Only one variable, skin awareness, was significantly associated with melanoma mortality in both groups. The variables that differed between the age-groups were anatomic site, Breslow thickness, histologic subtype, mitoses, tumor-infiltrating lymphocytes (TILs), and solar elastosis. Read More

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http://doi.wiley.com/10.1111/pcmr.12770
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http://dx.doi.org/10.1111/pcmr.12770DOI Listing
January 2019
1 Read

Linear focal elastosis localized to bilateral knee of a marathon runner.

J Postgrad Med 2019 Jan-Mar;65(1):60-61

Department of Pathology, University College of Medical Sciences and GTB Hospital (University of Delhi), New Delhi, India.

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http://dx.doi.org/10.4103/jpgm.JPGM_494_18DOI Listing
January 2019

Cutaneous Elastic Tissue Anomalies.

Am J Dermatopathol 2019 Feb;41(2):85-117

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

After a review of the physiology in the formation and degradation of cutaneous elastic tissue, we describe the clinicopathologic disorders characterized by increased and decreased cutaneous elastic tissue. Cutaneous disorders characterized by increased and/or abnormal elastic tissue in the dermis include elastoma, also named nevus elasticus, dermatosis lenticularis disseminata, pseudoxanthoma elasticum, late-onset focal dermal elastosis, linear focal elastosis, elastoderma, elastofibroma dorsi, and elastosis perforans serpiginosa. In some of these conditions, the specific histopathologic diagnosis may be rendered with hematoxylin-eosin stain, whereas in other ones special elastic tissue stains are necessary to demonstrate the anomalies. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001275DOI Listing
February 2019
2 Reads

Effectiveness of Combining High-Intensity Focused Radiofrequency and Non-Ablative Fractional Laser for Improving the Appearance of the Aging Face and Neck

J Drugs Dermatol 2019 Jan;18(1):59-64

Background: The safety and effectiveness of high-intensity precision radiofrequency (RF) for rejuvenating the aging neck and face, and of fractional laser therapy for treating photodamaged skin have each been previously demonstrated. Objective: To assess the effects of combining high-intensity precision RF and fractional laser therapy for treating the aging face and neck. Methods and Materials: Subjects (N=19) with Fitzpatrick skin types I to VI and mild-to-moderate solar elastosis and sun or age-related pigmentation on the face and/or neck were sequentially treated with high-intensity precision RF and fractionated laser devices during the same session. Read More

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January 2019
1 Read

Squamous cell carcinoma with clear cell differentiation in an equine eyelid.

J Vet Diagn Invest 2019 Jan 19:1040638718824377. Epub 2019 Jan 19.

Michigan State University Veterinary Diagnostic Laboratory.

A 15-y-old Miniature horse mare had a 6-mo history of an ulcerated mass on the right lower eyelid. An incisional biopsy and a subsequent excisional biopsy were submitted to the Michigan State University Veterinary Diagnostic Laboratory for microscopic evaluation. Histologically, the incisional biopsy was composed of sheets of large neoplastic vacuolated polygonal cells. Read More

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http://dx.doi.org/10.1177/1040638718824377DOI Listing
January 2019

Lung Transplantation as Successful Treatment of End-stage Idiopathic Pleuroparenchymal Fibroelastosis: A Case Report.

Transplant Proc 2019 Jan - Feb;51(1):235-238. Epub 2018 Jun 28.

Thoracic Surgery and Lung Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

Pleuroparenchymal fibroelastosis (PPFE) is a rare condition, characterized by predominantly upper-lobe pleural and subjacent parenchymal fibrosis, the latter being intra-alveolar with accompanying elastosis of the alveolar walls that leads a clinical progression to respiratory failure. This condition may not be as rare as it seems to be, because nowadays the increasing awareness among specialists is raising the number of new diagnoses. Limited data are available about the prognosis, both for secondary and idiopathic forms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183084
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http://dx.doi.org/10.1016/j.transproceed.2018.04.071DOI Listing
June 2018
8 Reads

Histopathological and patient-related characteristics of basal cell carcinomas of the head and neck influencing therapeutic management.

Dermatol Reports 2018 Oct 4;10(2):7674. Epub 2018 Dec 4.

Department of Oral and Maxillofacial Surgery, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany.

The authors hypothesize that histopathological characteristics of basal cell carcinomas of the head and neck (BCCHN) have changed over time and the correlation of BCCHN localization and histological tumour type can help improving the number and quality of necessary therapeutic interventions. Information of 222 patients with 344 BCCHN was gained. Descriptive measures were compared to prior studies to prove whether or not characteristics of basal cell carcinomas or patients have changed over time. Read More

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http://dx.doi.org/10.4081/dr.2018.7674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291759PMC
October 2018
1 Read

Comparison of the Inflammatory Infiltrates in Tumoral Melanosis, Regressing Nevi, and Regressing Melanoma.

Am J Dermatopathol 2018 Dec 19. Epub 2018 Dec 19.

Department of Dermatology, University of Florida College of Medicine, Gainesville, FL.

Background: Tumoral melanosis (TM) is a histologic diagnosis characterized by abundant pigment-laden macrophages in the dermis. It is generally thought to represent a regressed melanoma, although it has also been reported after benign pigmented lesions as well. Determining the antecedent lesion in cases of TM is of clinical importance to accurately guide therapy and prognostication. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001346DOI Listing
December 2018
4 Reads

Linear focal elastosis: A case report and institutional case series of 22 patients.

Australas J Dermatol 2018 Dec 27. Epub 2018 Dec 27.

Department of Dermatology, Inje University Busan Paik Hospital, Busan, Korea.

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http://dx.doi.org/10.1111/ajd.12976DOI Listing
December 2018
1 Read

Pushing and loss of elastic fibers are highly specific for melanoma and rare in melanocytic nevi.

Arch Dermatol Res 2019 Mar 13;311(2):99-107. Epub 2018 Dec 13.

Dermatology Department, Inselspital Bern University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.

The histopathological differentiation of melanocytic nevi from malignant melanoma (MM) is based on well-known criteria, and is straightforward in the vast majority of cases. However, there are few cases of melanocytic lesions (ML), the diagnosis of which is very challenging or even impossible. Here we have studied several morphological characteristics with particular focus on elastic fibers (EF) to identify features, helpful for the distinction between nevi and MM. Read More

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http://link.springer.com/10.1007/s00403-018-1885-x
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http://dx.doi.org/10.1007/s00403-018-1885-xDOI Listing
March 2019
10 Reads

In vivo multiphoton microscopy of melasma.

Pigment Cell Melanoma Res 2018 Dec 1. Epub 2018 Dec 1.

Unilever R&D, Trumbull, Connecticut.

Melasma is a skin disorder characterized by hyperpigmented patches due to increased melanin production and deposition. In this pilot study, we evaluate the potential of multiphoton microscopy (MPM) to characterize non-invasively the melanin content, location, and distribution in melasma and assess the elastosis severity. We employed a clinical MPM tomograph to image in vivo morphological features in melasma lesions and adjacent normal skin in 12 patients. Read More

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http://doi.wiley.com/10.1111/pcmr.12756
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http://dx.doi.org/10.1111/pcmr.12756DOI Listing
December 2018
6 Reads

Histopathological comparison of lesional and perilesional skin in melasma: A cross-sectional analysis.

Indian J Dermatol Venereol Leprol 2018 Dec 5. Epub 2018 Dec 5.

Consultant Dermatologist and Epidemiologist, Mumbai, Maharashtra, India.

Background: Melasma is a common acquired hyperpigmentary disorder of the sun exposed skin, especially the face. The pathogenesis is unclear but interplay between genetic factors, hormones and ultraviolet radiation is important. We have evaluated the histological characteristics of melasma and compared the findings with adjacent normal skin. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_866_17DOI Listing
December 2018
3 Reads

Platelet-rich Plasma for Skin Rejuvenation and Treatment of Actinic Elastosis in the Lower Eyelid Area.

Cureus 2018 Jul 18;10(7):e2999. Epub 2018 Jul 18.

Plastic Surgery, Waldkrankenhaus Bonn, Bonn, DEU.

Background Treatment of the lower eyelid region to rejuvenate the skin or treat actinic elastosis often proves difficult. Established treatment options, such as hyaluronic acid injections, botulinum toxin injections, microneedling, skin resurfacing (microdermabrasion, chemical peel (exfoliation), laser treatment), as well as blepharoplasties and autologous fat transfers, can be associated with significant risks and increased patient burden. Furthermore, they may not be effective for treating the signs of skin aging or actinic elastosis, including dark rings under the eyes, a lack of volume and cutis laxa. Read More

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https://www.cureus.com/articles/11999-platelet-rich-plasma-f
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http://dx.doi.org/10.7759/cureus.2999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260498PMC
July 2018
21 Reads

A case of unilateral inflamed plaques with comedones of the face.

Dermatol Pract Concept 2018 Oct 31;8(4):292-294. Epub 2018 Oct 31.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.

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http://dx.doi.org/10.5826/dpc.0804a07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246051PMC
October 2018
7 Reads

Melasma: Updates and perspectives.

Exp Dermatol 2018 Nov 13. Epub 2018 Nov 13.

College of Medicine, Seoul National University Bundang Hospital, Seoul National University, Gyeonggi, Korea.

Management of melasma is highly challenging due to inconsistent treatment results and frequent relapses. However, recent studies revealed that melasma may not only be a disease of melanocytes, but also a photoaging skin disorder. Herein, we attempt to validate that melasma is indeed a photoaging disorder by presenting the histopathologic findings of melasma: solar elastosis, altered basement membrane, increased vascularization and increased mast cell count. Read More

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http://dx.doi.org/10.1111/exd.13844DOI Listing
November 2018
5 Reads

Hybrid palliation as a bridge to biventricular repair in critical aortic stenosis with coarctation.

Ann Thorac Surg 2018 Nov 8. Epub 2018 Nov 8.

Division of Congenital Heart Surgery, Department of Surgery, Medical College of Wisconsin; Herma Heart Institute, Children's Hospital of Wisconsin.

Optimal management- balloon dilation versus surgical valvotomy- of neonatal critical aortic stenosis (AS) remains controversial. We describe a term neonate with critical AS and coarctation, severe left ventricular (LV) dysfunction with endocardial fibro-elastosis palliated with surgical valvotomy and hybrid as a bridge to early biventricular repair. Initial repair consisted of commissurotomy to create bicuspid morphology with placement of bilateral pulmonary artery bands and maintenance of ductal patency with prostaglandin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975183161
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http://dx.doi.org/10.1016/j.athoracsur.2018.09.051DOI Listing
November 2018
15 Reads

Lesions Mimicking Melanoma at Dermoscopy Confirmed Basal Cell Carcinoma: Evaluation with Reflectance Confocal Microscopy.

Dermatology 2019 7;235(1):35-44. Epub 2018 Nov 7.

Dermatology Unit, Department of Surgical, Medical, Dental and Morphological Sciences with Interest Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena,

Background: Atypical basal cell carcinoma (BCC), characterized by equivocal dermoscopic features typical of malignant melanoma (MM), can be difficult to diagnose. Reflectance confocal microscopy (RCM) enables in vivo imaging at nearly histological resolution.

Objectives: To evaluate with RCM atypical melanocytic lesions identified in dermoscopy, according to common RCM criteria for the differential diagnosis of BCC, and to identify representative RCM parameters for superficial (sBCCs) and nonsuperficial (nsBCCs) basal cell carcinomas (BCCs). Read More

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https://www.karger.com/Article/FullText/493727
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http://dx.doi.org/10.1159/000493727DOI Listing
November 2018
12 Reads
1.685 Impact Factor

Dermal Lesions and Skin Cancer in Patients with Inflammatory Bowel Disease Receiving Immunosuppressive Therapy

Asian Pac J Cancer Prev 2018 Oct 26;19(10):2845-2851. Epub 2018 Oct 26.

Department of Cardiology, University Hospital of Ioannina, Greece. Email:

Background: Anti-TNFa medications represent the first effective biologic therapy for IBD that has largely revolutionized treatment. The aim of this study was to quantify the risk of MM and other skin cancers among patients from Northern Greece area with IBD who take immunosuppressive or biologic anti-TNF medications. Methods: The current study was conducted during a 3-year period (2014-2016). Read More

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http://journal.waocp.org/article_69805.html
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http://dx.doi.org/10.22034/APJCP.2018.19.10.2845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291021PMC
October 2018
7 Reads

Melanoma coexisting with solar elastosis: a potential pitfall in the differential diagnosis between nevus and melanoma.

Hum Pathol 2018 Oct 22. Epub 2018 Oct 22.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Melanomas, like non-melanoma skin cancers, are known to be causally related to sun exposure. It is therefore not surprising to see benign nevi and melanomas in a background of solar damage, which at times may complicate their distinction. Due to their long-standing nature, nevi often occur before the development of solar elastosis, and as such, are intimately associated with the solar elastosis. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.10.010DOI Listing
October 2018
2 Reads
2.770 Impact Factor

Claudin-1 expression decreases with increasing pathological grade in actinic keratosis and may be a marker of high-risk actinic keratosis.

Clin Exp Dermatol 2018 Oct 12. Epub 2018 Oct 12.

Department of Dermatology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.

Background: Actinic keratosis (AK) is a common sun-induced skin disorder that can progress to invasive squamous cell carcinoma. However, there is still no reliable method to predict high-risk AK.

Aim: To identify markers that reflect the biological behaviour of AK and to understand the pathogenesis of AK. Read More

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http://dx.doi.org/10.1111/ced.13810DOI Listing
October 2018
1 Read

[Multifocal chalazodermic amyloidosis: The concept of immunoglobulinemic elastopathy].

Ann Dermatol Venereol 2018 Dec 9;145(12):777-784. Epub 2018 Oct 9.

Clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1 place de l'hôpital, 67091, Strasbourg, France.

Introduction: Impairment of dermal elastic tissue occurs in different entities associated with immunoglobulins or immunoglobulin-derived protein-secreting clonal plasma cell proliferations, such as amyloid elastosis, anetodermic nodular amyloidosis or monoclonal gammopathy-associated cutis laxa. We report a case of cutaneous immunoglobulinemic amyloidosis revealed by a unique chalazodermic presentation and we review elastic tissue impairment in patients with monoclonal gammopathies.

Observation: A 67-year-old woman consulted for non-infiltrated anetodermic lesions on the upper left quadrant of her abdomen present for ten years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638183052
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http://dx.doi.org/10.1016/j.annder.2018.07.021DOI Listing
December 2018
7 Reads

Dermatological aspects of the S2k guidelines on Down syndrome in childhood and adolescence.

J Dtsch Dermatol Ges 2018 Oct;16(10):1289-1295

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetology, Saarland University Medical Center, Homburg, Germany.

With an incidence of 1 in 700 births, Down syndrome (DS) is not an uncommon condition. It is associated with various disorders of different organ systems. Serious disorders include cardiac defects and leukemia. Read More

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http://doi.wiley.com/10.1111/ddg.13665
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http://dx.doi.org/10.1111/ddg.13665DOI Listing
October 2018
4 Reads

Dermatologische Aspekte aus der S2k-Leitlinie zum Down-Syndrom im Kindes- und Jugendalter.

J Dtsch Dermatol Ges 2018 Oct;16(10):1289-1296

Universität des Saarlandes, Kliniken für Kinder- und Jugendmedizin, Sektion Pädiatrische Endokrinologie und Diabetologie, Homburg.

Das Down-Syndrom (DS) ist mit einer Inzidenz von 1 : 700 aller Geburten nicht selten und mit diversen Erkrankungen unterschiedlicher Organsysteme assoziiert. Zu den schwerwiegenden Erkrankungen zählen Herzfehler und Leukämie. Letztere zeigt sich im Neugeborenenalter und geht nicht immer in eine klassische myeloische Leukämie über (transiente myeloproliferative Erkrankung). Read More

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http://doi.wiley.com/10.1111/ddg.13665_g
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http://dx.doi.org/10.1111/ddg.13665_gDOI Listing
October 2018
4 Reads

Collagenous and elastotic marginal plaques of the hand: A potential clue to the diagnosis of alkaptonuria.

J Cutan Pathol 2019 Jan 5;46(1):74-79. Epub 2018 Nov 5.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

Collagenous and elastotic marginal plaques of the hand (CEMPH) is a rare, chronic keratoderma characterized by hyperkeratotic linear plaques located along the radial and ulnar aspects of the hands bilaterally. As an isolated finding, CEMPH occurs secondarily to chronic trauma and photodamage. Herein, CEMPH is described as a manifestation of alkaptonuria (AKU). Read More

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http://dx.doi.org/10.1111/cup.13368DOI Listing
January 2019
3 Reads

Keratotic papules in an annular arrangement.

JAAD Case Rep 2018 Oct 29;4(9):851-853. Epub 2018 Sep 29.

University of Texas Health at San Antonio, San Antonio, Texas.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126183017
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http://dx.doi.org/10.1016/j.jdcr.2018.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168923PMC
October 2018
3 Reads

The role of TERT promoter mutations in differentiating recurrent nevi from recurrent melanomas: A retrospective, case-control study.

J Am Acad Dermatol 2019 Mar 1;80(3):685-693. Epub 2018 Oct 1.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:

Background: Repigmentation at previous biopsy sites pose a significant diagnostic dilemma given clinical and histologic similarities between recurrent nevi and locally recurrent melanoma. Though common in melanoma, the role of TERT promoter mutations (TPMs) in recurrent nevi is unknown.

Objective: We investigated the role of TPMs in recurrent nevi and whether the presence of hotspot TPM distinguishes recurrent nevi from locally recurrent melanoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183264
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http://dx.doi.org/10.1016/j.jaad.2018.09.030DOI Listing
March 2019
3 Reads

Intratunical Injection of Stromal vascular fraction prevents Fibrosis in a Rat Model of Peyronie's Disease.

BJU Int 2018 Sep 29. Epub 2018 Sep 29.

Laboratory for Experimental Urology, Organ systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium.

Objective: Previous studies have shown that the injection of adipose tissue-derived stem cells (ADSCs) into the tunica albuginea (TA) during the active phase of the Peyronie's disease (PD) prevents the development of fibrosis and elastosis in the TA and corpus cavernosum The aim of this study was to investigate whether local injection of autologous adipose stromal vascular fraction (SVF) can prevent the development of fibrosis and elastosis in the TA using a rat model of acute phase of the Peyronie's disease (PD) METHODS: A total of 24 male 12-wk-old Sprague-Dawley rats were divided in three equal groups: sham, PD without treatment (TGFB) and PD treated with SVF (SVF) 1 day after disease induction. Sham rats underwent 2 injections of vehicle into the TA one day apart. TGFB rats underwent TGF- β1 injection and injection of vehicle one day later. Read More

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http://dx.doi.org/10.1111/bju.14570DOI Listing
September 2018
7 Reads

Resurfacing with Ablation of Periorbital Skin Technique: Indications, Efficacy, Safety, and 3D Assessment from a Pilot Study.

Photomed Laser Surg 2018 Oct 20;36(10):541-547. Epub 2018 Sep 20.

8 Istituto di diagnosi e terapie dermatologiche ed estetiche (ISDET) , Bari, Italy .

Objectives And Background: Nowadays, several approaches for skin rejuvenation of the lower eyelid are available. We present a new technique of resurfacing with ablation of periorbital skin (RAP) performed in a single session.

Methods: This is a retrospective study involving 20 patients showing skin elastosis with or without evidence of the nasojugal fold and atrophic and dyschromic skin or needing a combined approach of transconjuntival lower blepharoplasty for fat bag removal. Read More

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https://www.liebertpub.com/doi/10.1089/pho.2018.4479
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http://dx.doi.org/10.1089/pho.2018.4479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199626PMC
October 2018
13 Reads
1.580 Impact Factor

Airway-Centered Pleuroparenchymal Fibroelastosis Associated with Non-Necrotizing Granulomas: A Rare New Entity.

Pathobiology 2018 17;85(5-6):276-279. Epub 2018 Sep 17.

Azienda USL Romagna, Department of Thoracic Diseases, Ospedale GB Morgagni, Forlì, Italy.

Pleuroparenchymal fibroelastosis is a rare form of upper-lobe-dominant progressive pulmonary fibrosis characterized histologically by visceral pleural thickening with collagenous fibrosis, subpleural elastosis, and intra-alveolar collagenous fibrosis. It was first described 25 years ago by Amitani et al. This report firstly describes a new variant or rare phenotype of PPFE with airway involvement, minimal pleuroparenchymal connections, and non-necrotizing granulomas. Read More

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http://dx.doi.org/10.1159/000492431DOI Listing
December 2018
2 Reads

Elastin molecular aging promotes MDA-MB-231 breast cancer cell invasiveness.

FEBS Open Bio 2018 Sep 2;8(9):1395-1404. Epub 2018 Aug 2.

UMR CNRS/URCA 7369 SFR CAP Santé Faculty of Sciences University of Reims Champagne-Ardenne France.

Elastin is a long-lived extracellular matrix protein responsible for the structural integrity and function of tissues. Breast cancer elastosis is a complex phenomenon resulting in both the deposition of elastotic masses and the local production of elastin fragments. In invasive human breast cancers, an increase in elastosis is correlated with severity of the disease and age of the patient. Read More

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http://dx.doi.org/10.1002/2211-5463.12455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120250PMC
September 2018
1 Read

A risk model for the prediction of skin tears in aged care residents: A prospective cohort study.

Int Wound J 2019 Feb 2;16(1):52-63. Epub 2018 Sep 2.

School of Public Health, Curtin University, Perth, Western Australia, Australia.

The objective of this study was to construct a predictive model to identify aged care residents at risk of future skin tears. Extensive data about individual characteristics, skin characteristics, and skin properties were gathered from 173 participants at baseline and at 6 months. A predictive model, developed using multivariable logistic regression, identified five variables that significantly predicted the risk of skin tear at 6 months. Read More

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http://doi.wiley.com/10.1111/iwj.12985
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http://dx.doi.org/10.1111/iwj.12985DOI Listing
February 2019
7 Reads

Elastosis perforans serpiginosa: causes and associated disorders.

Eur J Dermatol 2018 Aug;28(4):476-481

Department of Surgical, Microsurgical and Medical Sciences, Dermatology, University of Sassari, Italy.

Background: Elastosis perforans serpiginosa (EPS) is an uncommon cutaneous disorder classified under perforating diseases (PD); a group of dermatoses with transepidermal extrusion of collagen or elastic tissue. Three EPS subtypes have been reported that differ according to aetiology, associated diseases, and histopathological features. Herein, we report a systematic review of the literature, as well as a case of a 41-year-old woman with Wilson disease treated with penicillamine (PCM), who developed EPS after 11 years of drug intake. Read More

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http://dx.doi.org/10.1684/ejd.2018.3355DOI Listing
August 2018
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Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing.

Nutr Res 2018 09 9;57:97-108. Epub 2018 Jun 9.

Research and Development Department, MINERVA Research Labs, 1-6 Yarmouth Place, London, W1J 7BU, UK. Electronic address:

Aging is a multifactorial and natural process that causes physiological changes in organs, tissues and cells over time. In the skin and cartilage, aging leads to a decrease in the synthesis and changes in the arrangement of proteoglycans and collagen, in addition to the loss of glycosaminoglycans, which are responsible for the integrity and health of these tissues. We hypothesized that daily oral supplementation with a liquid nutraceutical containing hydrolyzed fish collagen, vitamins, antioxidants and other active ingredients could improve skin texture and elasticity, and in addition have a protective effect on joint health. Read More

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http://dx.doi.org/10.1016/j.nutres.2018.06.001DOI Listing
September 2018
10 Reads

Sequential facial skin rejuvenation with intense pulsed light and non-ablative fractionated laser resurfacing in fitzpatrick skin type II-IV patients: A prospective multicenter analysis.

Lasers Surg Med 2019 Feb 8;51(2):141-149. Epub 2018 Aug 8.

Dermatological Practice-Laser Center, Konz, Germany.

Background: While skin aging is triggered by multiple factors and typically presents with multiple manifestations, conventional treatment regimens deploy a single treatment modality. Typical approaches exploit ablative techniques, which involve considerable patient discomfort and downtime and can induce adverse events. Non-ablative fractionated laser (NAFL) resurfacing promotes neocollagenesis, with significantly fewer complications and discomfort. Read More

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http://doi.wiley.com/10.1002/lsm.23007
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http://dx.doi.org/10.1002/lsm.23007DOI Listing
February 2019
11 Reads

Acquired elastotic hemangioma, a little-known entity: report of a case with 15 years of evolution.

An Bras Dermatol 2018 Jul-Aug;93(4):559-561

Dermatology Service, Hospital do Servidor Público Estadual de São Paulo, São Paulo (SP), Brazil.

Acquired elastotic hemangioma is a hemangioma variant first described in 2002. It is characterized by being a benign, solitary, slow-growing lesion, that appears in adulthood and is associated with solar exposure. It is a rare hemangioma variant with few cases reported in the literature. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063116PMC
September 2018
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Atrophic and Annular Scarring Alopecia of the Scalp as a Finding in Underlying Systemic Sarcoidosis.

Acta Dermatovenerol Croat 2017 Dec;25(4):298-299

Dario Didona, MD, Prima Divisione Dermatologica , Istituto Dermopatico dell'Immacolata-IRCCS, Via dei Mont di Creta 104 , 00167 Rome, Italy;

Cutaneous sarcoidosis is not an uncommon disorder, and the skin can be the sole manifestation in about 10% of patients. However, when the involved anatomical area of the cutaneous sarcoidosis is the scalp and it presents as a scarring alopecia, there is an increased risk of a systemic disease (1,2). A 79-year-old Caucasian male patient presented to our Institute with annular and painless plaques of the scalp, with variable diameter, showing a reddish and yellowish color (Figure 1, a). Read More

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December 2017
15 Reads

Understanding Solar Skin Elastosis-Cause and Treatment.

J Cosmet Sci 2018 May/Jun;69(3):175-185

BASF Beauty Care Solutions, Lyon 69007, France (S.P., N.B., C.N., V.D., V.A.).

Photoageing, also called actinic ageing, is the main cause of prematurely aged skin. Our expertise in elastic fibers has led us to discover a process triggered in response to ultraviolet (UV) light and which upsets the balance of elastin fibers: there is too much elastin and insufficient lysyl oxidase (LOXL1) enzyme to form functional elastic fibers. This imbalance then leads to an accumulation of nonfunctional elastin, which forms aggregates. Read More

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September 2018
13 Reads

Nevus-Associated Melanoma: Patient Phenotype and Potential Biological Implications.

J Invest Dermatol 2018 Aug;138(8):1696-1698

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Italy; Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy.

Pandeya et al. report that nevus-associated melanoma is associated with a specific phenotype, namely, young age, high number of nevi, non-brown eye color and slight dermal elastosis. Potential implications regarding differences between nevus-associated melanomas and de novo melanomas are discussed. Read More

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http://dx.doi.org/10.1016/j.jid.2018.01.025DOI Listing
August 2018
4 Reads

Linearized solar elastosis of the legs: A novel presentation and review of the literature.

J Cutan Pathol 2018 Nov 15;45(11):855-857. Epub 2018 Aug 15.

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.

There exists a spectrum of solar elastotic variants based on the clinical and histopathologic findings. We present here a peculiar case of solar elastosis that is unusual in its anatomic location, relative lack of background actinic damage, and pattern of linearization. Its presentation suggests that other factors in addition to ultraviolet radiation may play a role in the pathogenesis of solar elastosis. Read More

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http://dx.doi.org/10.1111/cup.13325DOI Listing
November 2018
5 Reads

Reflectance confocal microscopy features of melanomas on the body and non-glabrous chronically sun-damaged skin.

J Cutan Pathol 2018 Oct 31;45(10):754-759. Epub 2018 Jul 31.

Sheba Medical Center and Sackler Faculty of Medicine, Medical Screening Institute, Tel Aviv University, Tel Aviv, Israel.

Background: Melanoma remains a challenge to diagnose, especially when appearing on the background of chronically sun-damaged skin (CSDS). Our goal was to identify and quantify the reflectance confocal microscopy (RCM) features of melanoma on non-facial CSDS.

Methods: Included lesions were biopsy-proven melanomas, from anatomic sites other than the face, neck, scalp and acral skin, with histopathologic finding of solar elastosis in the underlying dermis. Read More

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http://www.vivascope-pub.com/medical/in-vivo/melanoma-pigmen
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https://www.researchgate.net/publication/232224129_In_vivo_c
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https://onlinelibrary.wiley.com/doi/pdf/10.1111/cup.13084
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http://doi.wiley.com/10.1111/cup.13318
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http://dx.doi.org/10.1111/cup.13318DOI Listing
October 2018
20 Reads

Physical properties of the photodamaged human skin dermis: Rougher collagen surface and stiffer/harder mechanical properties.

Exp Dermatol 2018 Jun 29. Epub 2018 Jun 29.

Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan.

Fragmentation of collagen fibrils and aberrant elastic material (solar elastosis) in the dermal extracellular matrix (ECM) is among the most prominent features of photodamaged human skin. These alterations impair the structural integrity and create a dermal microenvironment prone to skin disorders. The objective of this study was to determine the physical properties (surface roughness, stiffness and hardness) of the dermal ECM in photodamaged and subject-matched sun-protected human skin. Read More

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http://doi.wiley.com/10.1111/exd.13728
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http://dx.doi.org/10.1111/exd.13728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311145PMC
June 2018
7 Reads

Dual wavelength treatment protocol with a picosecond laser for the reduction of facial wrinkles.

Authors:
Michael H Gold

J Cosmet Laser Ther 2018 Jun 8:1-5. Epub 2018 Jun 8.

a Tennessee Clinical Research Center, Gold Skin Care Center , Nashville , TN, USA.

Introduction: The potential of a dual wavelength picosecond laser, as a new modality for treating photoaged skin, was investigated in this clinical study.

Material And Methods: Subjects with bilateral mild-to-moderate facial wrinkling received four picosecond laser treatments, at 3-8 weeks apart, with a double-pass of both 532-nm and 1064-nm split-beam handpieces. Blinded evaluation of clinical photography, by two independent physicians, using the Fitzpatrick Elastosis Scale, was performed at 12 weeks after the fourth treatment. Read More

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http://dx.doi.org/10.1080/14764172.2018.1481514DOI Listing
June 2018
2 Reads

Extracellular matrix and fibroblast injection produces pterygium-like lesion in rabbits.

Biol Res 2018 Jun 5;51(1):15. Epub 2018 Jun 5.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, 64710, Monterrey, NL, Mexico.

Background: Translational research to develop pharmaceutical and surgical treatments for pterygium requires a reliable and easy to produce animal model. Extracellular matrix and fibroblast are important components of pterygium. The aim of this study was to analyze the effect of the subconjunctival injection of fibroblast cells (NIH3T3 cell line) and exogenous extracellular matrix in rabbits in producing a pterygium-like lesion. Read More

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http://dx.doi.org/10.1186/s40659-018-0165-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987467PMC
June 2018
18 Reads

Case of late-onset focal dermal elastosis.

J Dermatol 2018 Dec 31;45(12):e339-e340. Epub 2018 May 31.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

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http://dx.doi.org/10.1111/1346-8138.14472DOI Listing
December 2018
1 Read