3,530 results match your criteria Ehrlichiosis


Molecular Detection of and Species in Ticks Removed from Humans in the Republic of Korea.

Microorganisms 2022 Jun 15;10(6). Epub 2022 Jun 15.

Division of Vectors and Parasitic Diseases, Korea Disease Control and Prevention Agency, 187 Osongsaenmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju 28159, Chungbuk, Korea.

Human granulocytic anaplasmosis (HGA) and human monocytic ehrlichiosis (HME) are zoonotic tick-borne diseases transmitted via tick bites. To determine the state of human and infections caused by tick bites in the Republic of Korea (ROK), we conducted a nationwide investigation of human cases of tick bites in 2020. A total of 180 ticks were obtained, comprising (70. Read More

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Vector-borne pathogens in dogs from areas where leishmaniosis is endemic.

Vet Parasitol Reg Stud Reports 2022 Jul 9;32:100746. Epub 2022 Jun 9.

Department of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy.

Many vector-borne pathogens (VBPs), including Ehrlichia canis and Dirofilaria immitis, may infect simultaneously dogs in areas where Leishmania infantum is endemic, especially in the tropics, where highly abundant arthropod vectors thrive. The aim of this study was to compare the frequency of simultaneous VBPs infection in Leishmania-positive and Leishmania-negative dogs. Animals enrolled in this study were divided in two groups (G1 and G2), G1 being comprised of L. Read More

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Ehrlichiosis in a Recent Liver Transplant Recipient Leading to Multiorgan Failure.

Case Rep Transplant 2022 10;2022:3062836. Epub 2022 Jun 10.

Department of Surgery, Saint Louis University, St. Louis, MO, USA.

Ehrlichia infection has a broad spectrum of diseases ranging from asymptomatic to fatal. While Ehrlichia often presents as a mild form of the disease in immunocompetent patients, immunosuppressed patients are at increased risk for a more virulent and potentially fatal infection. Our liver transplant patient presented with fever, persistent headaches, and negative Ehrlichia antibodies. Read More

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Molecular detection of vector-borne agents in wild boars (Sus scrofa) and associated ticks from Brazil, with evidence of putative new genotypes of Ehrlichia, Anaplasma and hemoplasmas.

Transbound Emerg Dis 2022 Jun 19. Epub 2022 Jun 19.

Department of Pathology, Reproduction, and One Health - Faculty of Agricultural and Veterinary Sciences/University State Paulista (FCAV/UNESP), Jaboticabal, SP, Brazil.

The present study aimed to investigate, by molecular techniques, the occurrence of Anaplasmataceae, Bartonellaceae, Rickettsiaceae, Mycoplasmataceae, Coxiellaceae e Babesiidae/Theileriidae agents in blood samples of free-living wild boars (Sus scrofa) and associated ticks in southeastern Brazil. For this purpose, 67 blood samples and 265 ticks (264 Amblyomma sculptum and one A. ovale) were analyzed. Read More

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Seropositivity of main vector-borne pathogens in dogs across Europe.

Parasit Vectors 2022 Jun 6;15(1):189. Epub 2022 Jun 6.

Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.

Background: Canine vector-borne disease (CVBD) has been an area of increasing interest in Europe over the last few decades, and there have been changes in the prevalence and distribution of many of these diseases. Monitoring CVBD infections in Europe is often done by individual countries, but aggregated data for the European countries are helpful to understand the distribution of CVBDs.

Methods: We used an extensive retrospective database of results from point-of-care rapid enzyme-linked immunosorbent assay (ELISA) tests on dogs across Europe to identify distribution and seropositivity in animals tested for selected CVBDs (Anaplasma spp. Read More

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Current and Future Molecular Diagnostics of Tick-Borne Diseases in Cattle.

Vet Sci 2022 May 21;9(5). Epub 2022 May 21.

College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766, USA.

Ticks and tick-borne diseases such as babesiosis, anaplasmosis, ehrlichiosis, Lyme disease, Crimean Congo hemorrhagic fever, and Rocky Mountain spotted fever pose a significant threat to animal and human health. Tick-borne diseases cause billions of dollars of losses to livestock farmers annually. These losses are partially attributed to the lack of sensitive, robust, cost effective and efficient diagnostic approaches that could detect the infectious pathogen at the early stages of illness. Read More

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Suppurative spinal meningomyelitis in a dog with intra-neutrophilic cerebrospinal fluid cells Ehrlichia canis morulae.

Vet Clin Pathol 2022 May 23. Epub 2022 May 23.

Department of Neurology, Centre Hospitalier Vétérinaire Frégis, Paris, France.

A 2-year-old castrated male Creole Shepherd mixed dog was presented for non-ambulatory paraparesis of the pelvic limbs. The magnetic resonance imaging and cerebrospinal fluid (CSF) analysis were consistent with meningomyelitis. Positive serology for Ehrlichia canis/Ehrlichia ewingii suggested exposure to a pathogen; qPCR on the serum and the CSF confirmed active infection. Read More

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Benefits, companion animal zoonotic disease prevalence and public perceptions of pet ownership among people experiencing homelessness in northern California.

Zoonoses Public Health 2022 May 23. Epub 2022 May 23.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.

California has the highest proportion of unhoused individuals in the country, and up to 25% of unhoused individuals own pets, providing substantial benefits but unique challenges including access to housing, transportation and unfounded grounds for social stigmatization. Unhoused individuals and pets may also be at risk for diseases due to impaired access to sanitation facilities. The purpose of this cross-sectional survey was to evaluate differences in perceived benefits, challenges and public perceptions among pet owners of varying housing security and the prevalence of diseases among their pets. Read More

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and Other Vector-Borne Infections in Shelter Dogs in Two Counties of Oklahoma, United States.

Vector Borne Zoonotic Dis 2022 May;22(5):273-280

Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.

is an emerging zoonotic vector-borne parasite infecting dogs and other mammals in the United States. In this study we evaluated shelter dogs in one northeastern and one southeastern county in Oklahoma for prevalence of exposure to . Dogs were tested for antibodies against using the Chagas STAT PAK assay and for in circulation by PCR. Read More

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Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular program.

PLoS Pathog 2022 05 16;18(5):e1010345. Epub 2022 May 16.

Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America.

Ehrlichia chaffeensis (E. chaffeensis) has evolved eukaryotic ligand mimicry to repurpose multiple cellular signaling pathways for immune evasion. In this investigation, we demonstrate that TRP120 has a novel repetitive short linear motif (SLiM) that activates the evolutionarily conserved Hedgehog (Hh) signaling pathway to inhibit apoptosis. Read More

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Patterns Testing for Tick-Borne Diseases and Implications for Surveillance in the Southeastern US.

JAMA Netw Open 2022 05 2;5(5):e2212334. Epub 2022 May 2.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Importance: Tick-borne diseases (TBD), including spotted fever group rickettsiosis (SFGR), ehrlichiosis, and, increasingly, Lyme disease, represent a substantial public health concern throughout much of the southeastern United States. Yet, there is uncertainty about the epidemiology of these diseases because of pitfalls in existing diagnostic test methods.

Objective: To examine patterns of diagnostic testing and incidence of TBD in a large, academic health care system. Read More

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Evaluation of a multi-species Protein A-ELISA assay for plague serologic diagnosis in humans and other mammal hosts.

PLoS Negl Trop Dis 2022 05 12;16(5):e0009805. Epub 2022 May 12.

Departamento de Microbiologia - Instituto Aggeu Magalhães; FIOCRUZ -PE. Recife, Brazil.

Background: The Hemagglutination assay (HA) is widely used in plague diagnosis, however, it has a subjective interpretation and demands high amounts of antigen and other immunobiological supplies. On the other hand, the conventional Anti-IgG ELISA is limited by the need of specific conjugates for multiple plague hosts, which leaves a gap for new diagnostic methods able to cover both the diagnosis of human cases and the epidemiological surveillance of multiple sentinel species.

Methods: We developed an ELISA Protein A-peroxidase method to detect anti-F1 antibodies across several species, including humans. Read More

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Detection of vector-borne pathogens in owned dogs with cranial cruciate ligament rupture living in the Mediterranean area.

Parasit Vectors 2022 May 10;15(1):105. Epub 2022 May 10.

Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Carrer de l´Hospital s/n, 08193, Bellaterra, Spain.

Background: Cranial cruciate ligament rupture (CCLR) results from a multifactorial degenerative process that leads to rupture of the ligament. Vector-borne pathogens (VBP) in dogs can induce joint disease but their role in CCLR has not been previously investigated. The aim of the present work is to evaluate the prevalence of VBP in dogs with CCLR. Read More

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Vector-borne pathogens of zoonotic concern in hunting dogs of southern Italy.

Acta Trop 2022 Aug 18;232:106502. Epub 2022 May 18.

Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano (Bari), Italy; Faculty of Veterinary Sciences, Bu-Ali Sina University, Hamedan, Iran. Electronic address:

Dogs are commonly exposed to vector-borne pathogens (VBPs), yet few data are available on hunting dogs, which are often at high risk of infection due to their involvement in field activities. To investigate the occurrence of VBPs and evaluate the relative performance of different diagnostic tools, blood and serum samples were collected from hunting dogs (n = 1,433) in rural areas of southern Italy. All samples were tested by Knott's technique for filarioids, serologically (SNAP® 4Dx® Plus) for Anaplasma spp. Read More

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[Role of systemic infections in canine kidney diseases].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2022 Apr 6;50(2):124-136. Epub 2022 May 6.

Medizinische Kleintierklinik, Zentrum für klinische Tiermedizin, Ludwig-Maximilians-Universität München.

Kidney diseases represent a common problem as well as a frequent cause of death in dogs. Infectious agents may be responsible for glomerulopathies and acute kidney injuries. Many infections commonly associated with the development of immune complex glomerulonephritis in central and southern Europe are important as travel-associated diseases in Germany. Read More

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Systematic evaluation of TaqMan real-time polymerase chain reaction assays targeting the and loci of in recombinant plasmids and naturally infected dogs.

Vet World 2022 Mar 25;15(3):701-706. Epub 2022 Mar 25.

Department of Veterinary Technology, Faculty of Veterinary Technology, Kasetsart University, Bangkok, Thailand.

Background And Aim: Because of the diversity of local genotypes of , genes targeted by TaqMan real-time polymerase chain reaction (RT-PCR) assays should be systematically evaluated. This study evaluated the amplification efficiency, linearity, precision, and sensitivity of two TaqMan RT-PCR assays targeting the and loci of in recombinant plasmids and naturally infected dogs.

Materials And Methods: Thirty blood samples were collected from dogs showing clinical signs of canine monocytic ehrlichiosis at the Kasetsart University Veterinary Teaching Hospital, Bangkok, Thailand. Read More

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A newly developed droplet digital PCR for Ehrlichia canis detection: comparisons to conventional PCR and blood smear techniques.

J Vet Med Sci 2022 Jun 27;84(6):831-840. Epub 2022 Apr 27.

Department of Veterinary Technology, Faculty of Veterinary Technology, Kasetsart University, Bangkok, Thailand.

Canine monocytic ehrlichiosis caused by Ehrlichia canis infection is a life-threatening vector-borne disease in dogs worldwide. Routine blood smear has very low sensitivity and cannot accurately provide a quantitative result. Conventional PCR (cPCR) and real-time PCR (qPCR) are widely used as molecular methods for E. Read More

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Assessing Tick-Borne Disease Risk and Surveillance: Toward a Multi-Modal Approach to Diagnostic Positioning and Prediction.

Microorganisms 2022 Apr 18;10(4). Epub 2022 Apr 18.

Laboratory for Human Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA.

The true extent of tick-borne disease (TBD) incidence and risk among humans is largely unknown, posing significant public health challenges. This study offers an exploratory analysis of a multimodal dataset and is part of a larger ongoing project to determine if entomological data, canine serological reports, self-reported human tick bite encounters (TBEs), and/or associated TBD diagnoses can serve as proxies for human disease risk. Focusing on the United States (U. Read More

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Glutathione Synthesis Regulated by CtrA Protects From Host Cell Oxidative Stress.

Front Microbiol 2022 30;13:846488. Epub 2022 Mar 30.

Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.

, a small Gram-negative obligatory intracellular bacterium, infects human monocytes or macrophages, and causes human monocytic ehrlichiosis, one of the most prevalent, life-threatening emerging zoonoses. Reactive oxygen species are produced by the host immune cells in response to bacterial infections. The mechanisms exploited by to resist oxidative stress have not been comprehensively demonstrated. Read More

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Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis.

Rev Bras Parasitol Vet 2022 8;31(2):e021621. Epub 2022 Apr 8.

Departamento de Patologia, Reprodução e Saúde Única, Faculdade Ciências Agrárias e Veterinárias - FCAV, Universidade Estadual Paulista - UNESP, Jaboticabal, SP, Brasil.

Canine monocytic ehrlichiosis (CME) is one of the most important tick-borne diseases worldwide, with multisystemic presentations. Immune dysregulation has been proposed as the primary mechanism involved in its pathogenesis and in tissue injury in dogs with CME. Experimental infection of German Shepherd dogs in the present study demonstrated that CME caused marked pathological changes in their lymph nodes and spleen, and also gave rise to mononuclear infiltration in organs and tissues. Read More

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Invasive raccoon (Procyon lotor) and raccoon dog (Nyctereutes procyonoides) as potential reservoirs of tick-borne pathogens: data review from native and introduced areas.

Parasit Vectors 2022 Apr 11;15(1):126. Epub 2022 Apr 11.

Department of Parasitology, Faculty of Biological Sciences, University of Wrocław, Wrocław, Poland.

In recent decades, populations of the raccoon (Procyon lotor) and the raccoon dog (Nyctereutes procyonides) have increased and adapted to peri-urban and urban environments in many parts of the world. Their ability to rapidly colonize new territories, high plasticity and behavioral adaptation has enabled these two species to be considered two of the most successful invasive alien species. One of the major threats arising from continually growing and expanding populations is their relevant role in maintaining and transmitting various vector-borne pathogens among wildlife, domestic animals and humans. Read More

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Ehrlichiosis mimicking acute leukemia.

IDCases 2022 25;28:e01480. Epub 2022 Mar 25.

The University of Kansas Medical Center, Division of Infectious Diseases, Kansas City, KS, USA.

Human monocytic ehrlichiosis is a tickborne disease with a spectrum of presentations ranging from asymptomatic, mild to fatal. Ehrlichiosis can transiently cause white blood cells abnormalities that mimic leukemia/lymphoma and cases have been, on rare occasions, initially mistaken for hematological malignancies. We report a case of infection suspected to be acute promyelocytic leukemia at presentation, prompting therapy with all-trans-retinoic acid. Read More

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Retrospective analysis of canine monocytic ehrlichiosis in Thailand with emphasis on hematological and ultrasonographic changes.

Vet World 2022 Jan 5;15(1):1-9. Epub 2022 Jan 5.

Parasitology Unit, Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.

Background And Aim: Canine monocytic ehrlichiosis (CME) is a tropical endemic tick-borne disease that causes fatality or chronic infection involving many organs in dogs. This study aimed to examine the prevalence, risk factors, and hematological and ultrasonographic changes in the liver, gallbladder, kidneys, and spleen following CME infection.

Materials And Methods: This retrospective study used 30,269 samples collected from dogs at the hematology section of the pathology unit of a university veterinary hospital and 35 samples collected from dogs at the diagnostic imaging unit. Read More

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January 2022

The economic impact of heartwater on the South African livestock industry and the need for a new vaccine.

Prev Vet Med 2022 Jun 29;203:105634. Epub 2022 Mar 29.

University of the Free State, Department of Agricultural Economics, P.O. Box 339, Internal box 58, Bloemfontein 9300, South Africa. Electronic address:

Heartwater is a dangerous tick-borne disease for livestock farmers in South Africa and results in annual economic losses for the livestock industry. This study determined the total economic impact of heartwater in South Africa by calculating this disease's direct and indirect costs. Survey data from 272 livestock farmers from six provinces of South Africa was used for this study. Read More

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SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes.

mBio 2022 04 31;13(2):e0007622. Epub 2022 Mar 31.

Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.

Ehrlichia chaffeensis evades innate host defenses by reprogramming the mononuclear phagocyte through mechanisms that involve the exploitation of multiple evolutionarily conserved cellular signaling pathways, including Notch. This immune evasion strategy is directed in part by tandem repeat protein (TRP) effectors. Specifically, the TRP120 effector activates and regulates Notch signaling through interactions with the Notch receptor and the negative regulator, F-Box and WD repeat domain-containing 7 (FBW7). Read More

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Development of inactivated heartwater (Ehrlichia ruminantium) vaccine in South Africa.

Ticks Tick Borne Dis 2022 05 20;13(3):101942. Epub 2022 Mar 20.

Agricultural Research Council-Onderstepoort Veterinary Research, Onderstepoort, Pretoria, 0110, South Africa; School of Life Sciences, University of KwaZulu-Natal, Durban, Westville, 4001, South Africa. Electronic address:

Heartwater, Ehrlichia ruminantium infection in cattle, sheep, goats, and some wild ruminants, is an economically important disease in Africa characterized by high mortality rates in susceptible populations. In South Africa, the current commercial heartwater vaccine is an infection and treatment type of immunization using virulent live E. ruminantium organisms generated from blood of infected sheep with subsequent treatment of the animals with antibiotics at specific times during the course of infection. Read More

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Molecular characterization of novel genotypes in from Uruguay.

Curr Res Parasitol Vector Borne Dis 2021 13;1:100022. Epub 2021 Apr 13.

Laboratorio de Vectores y Enfermedades Transmitidas, Departamento de Ciencias Biológicas, CENUR Litoral Norte - Salto, Universidad de la República, Rivera 1350, CP 50000 Salto, Uruguay.

are small intracellular Gram-negative bacteria transmitted by ticks. These microorganisms cause ehrlichiosis, a complex of life-threatening emerging zoonoses and diseases of global veterinary relevance. The aim of this study was to investigate the presence of in free-living collected in Uruguay. Read More

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Trigeminal Neuralgia As the Principal Manifestation of Anaplasmosis: A Case Report.

Cureus 2022 Jan 27;14(1):e21668. Epub 2022 Jan 27.

Infectious Diseases, Saint Vincent Hospital, Erie, USA.

Unlike the tick-borne diseases ehrlichiosis and Lyme disease, human granulocytic anaplasmosis is rarely associated with neurological complications. In this case report, we present a patient who developed a severe, lancinating headache shortly after known tick exposure. A tick-borne PCR panel was positive for and neurology evaluation yielded a concomitant diagnosis of new-onset trigeminal neuralgia. Read More

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January 2022

Tick magnets: The occupational risk of tick-borne disease exposure in forestry workers in New York.

Health Sci Rep 2022 Mar 23;5(2):e509. Epub 2022 Feb 23.

Research Institute Bassett Medical Center Cooperstown New York USA.

Background: Outdoor workers, such as forestry workers, are at an increased risk for contracting tick-borne diseases due to their prolonged time spent in tick habitats. Although well studied in Europe, no studies have been conducted with forestry workers in the Northeastern United States since 1990s.

Methods: Full-time forestry workers and two comparison groups (volunteer firefighter/first responders and indoor/healthcare workers) within New York State Department of Environmental Conservation Regions 3, 4, 5, 6, and 7 were recruited for this cross-sectional seroprevalence study. Read More

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Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis.

Antioxidants (Basel) 2022 Feb 8;11(2). Epub 2022 Feb 8.

Department of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, 98168 Messina, Italy.

The study aimed to evaluate the concentration of reactive oxidative metabolites (R-OOHs), the antioxidant barrier (OXY), and the ratio between R-OOHs and OXY (OSi) and thiol groups of plasma compounds (SHp) in in canine monocytic ehrlichiosis. Thirty dogs affected with monocytic ehrlichiosis (canine monocytic ehrlichiosis group-CME group) and ten healthy dogs (control group-CTR group) were evaluated. CME was diagnosed by the presence of clinical signs and the detection of anti- antibodies. Read More

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February 2022