3,418 results match your criteria Ehrlichiosis


Iron robbery by intracellular pathogen via bacterial effector-induced ferritinophagy.

Proc Natl Acad Sci U S A 2021 Jun;118(23)

Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210;

Iron is essential for survival and proliferation of an obligatory intracellular bacterium that causes an emerging zoonosis, human monocytic ehrlichiosis. However, how acquires iron in the host cells is poorly understood. Here, we found that native and recombinant (cloned into the genome) translocated factor-3 (Etf-3), a previously predicted effector of the type IV secretion system (T4SS), is secreted into the host cell cytoplasm. Read More

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Ehrlichia canis morulae in peripheral blood lymphocytes of two naturally-infected puppies in Israel.

Vet Parasitol Reg Stud Reports 2021 Apr 10;24:100554. Epub 2021 Mar 10.

Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O Box 12, Rehovot, 761001, Israel.

Ehrlichia canis is the major causative agent of canine monocytic ehrlichiosis (CME). Its morulae might be detected during the acute disease phase, usually within peripheral blood monocytes, but were uncommonly described within peripheral blood lymphocytes. This report describes two unrelated puppies, naturally infected with E. Read More

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Determination of Serum Oxidative Stress, Antioxidant Capacity and Protein Profiles in Dogs Naturally Infected with Ehrlichia canis.

Acta Parasitol 2021 May 20. Epub 2021 May 20.

Department of Biochemistry, Faculty of Veterinary Medicine, University of Mustafa Kemal University, Hatay, Turkey.

Purpose: Canine ehrlichiosis is an important tick-borne disease of dogs worldwide. In the present study, we aimed to determine the serum total antioxidant capacity (TAC), malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase, (SOD), glutathione peroxidase (GSH-Px), adenosine deaminase (ADA) activity and serum protein profiles in dogs affected with naturally acquired ehrlichiosis.

Methods: The animal materials had been consisted of ten dogs naturally infected with Ehrlichia canis, and ten controls negative for Ehrlichia canis. Read More

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Serological evidence of Ehrlichia minasensis infection in Brazilian dogs.

Acta Trop 2021 Jul 24;219:105931. Epub 2021 Apr 24.

Laboratory of Virology and Rickettsiosis, Faculty of Veterinary Medicine, Federal University of Mato Grosso, Cuiabá, MT, Brazil. Electronic address:

Ehrlichia spp. are important tick-borne pathogens of animals in Brazil, and Ehrlichia canis is the most prevalent species infecting dogs. Moreover, Ehrlichia minasensis has also recently been identified as a novel ehrlichial agent that infects cattle in Brazil. Read More

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Ehrlichia-induced hemophagocytic lymphohistiocytosis after autologous stem cell transplant.

Transpl Infect Dis 2021 Apr 20:e13621. Epub 2021 Apr 20.

The Myeloma Center, Division of Hematology/Oncology, UAMS, Little Rock, AR, USA.

Hemophagocytic lymphohistiocytosis (HLH) causes multiorgan failure due to the release of multiple cytokines mediating widespread inflammation. We present a patient with multiple myeloma on maintenance chemotherapy with the anti-CD38 monoclonal antibody daratumumab after autologous stem cell transplant (ASCT) who developed fatal HLH secondary to Ehrlichiosis. Read More

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Mutations in Ehrlichia chaffeensis Genes ECH_0660 and ECH_0665 Cause Transcriptional Changes in Response to Zinc or Iron Limitation.

J Bacteriol 2021 Jun 8;203(13):e0002721. Epub 2021 Jun 8.

Center of Excellence for Vector-Borne Diseases, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.

Ehrlichia chaffeensis causes human monocytic ehrlichiosis by replicating within phagosomes of monocytes/macrophages. A function disruption mutation within the pathogen's ECH_0660 gene, which encodes a phage head-to-tail connector protein, resulted in the rapid clearance of the pathogen , while aiding in induction of sufficient immunity in a host to protect against wild-type infection challenge. In this study, we describe the characterization of a cluster of seven genes spanning from ECH_0659 to ECH_0665, which contained four genes encoding bacterial phage proteins, including the ECH_0660 gene. Read More

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Development and validation of real-time PCR assays for the detection of Ehrlichia species and E. chaffeensis in clinical specimens.

J Microbiol Methods 2021 Jul 16;186:106225. Epub 2021 Apr 16.

Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America. Electronic address:

Ehrlichiosis, caused by Gram-negative bacteria of the genus Ehrlichia, is considered an emerging infectious disease due to the increasing number of reported cases. Symptoms are non-specific and occur within 1 to 2 weeks following the bite of an infected tick. Confirmatory laboratory diagnostic methods vary in sensitivity and specimen requirements, which can lead to delayed diagnosis. Read More

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Molecular detection and characterization of Anaplasma platys and Ehrlichia canis in dogs from the Caribbean.

Ticks Tick Borne Dis 2021 07 9;12(4):101727. Epub 2021 Apr 9.

Center of Excellence for Vector-Borne Diseases (CEVBD), Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA. Electronic address:

Anaplasma platys is a tick-transmitted rickettsial pathogen, which is known to be the etiologic agent for cyclic thrombocytopenia in its primary canine host. Infections with this pathogen are also reported in cats, cattle and people. Similarly, Ehrlichia canis is another tick-borne rickettsial pathogen responsible for canine monocytic ehrlichiosis and is also reported to cause infections in people. Read More

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Trypanosoma cruzi co-infections with other vector borne diseases are frequent in dogs from the pacific coast of Ecuador.

Microb Pathog 2021 Jun 20;155:104884. Epub 2021 Apr 20.

Centro de Investigación y Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Km 15.5 Carretera Panamericana Toluca-Atlacomulco, Toluca, Estado de México, C.P. 50200, México.

Dogs are a reservoir for Chagas disease, caused by Trypanosoma cruzi (T. cruzi), and other companion vector-borne diseases, including ehrlichiosis (Ehrlichia canis and Ehrlichia ewingii), anaplasmosis (Anaplasma phagocytophilum and Anaplasma platys), dirofilariasis (Dirofilaria immitis) and Lyme disease (Borrelia burgdorferi). This study has two key objectives: 1) to determine seroreactivity against T. Read More

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One man, three tick-borne illnesses.

BMJ Case Rep 2021 Apr 16;14(4). Epub 2021 Apr 16.

Department of Internal Medicine, Providence Health and Services Oregon and Southwest Washington, Portland, Oregon, USA.

A 70-year-old man presented to the emergency department with fevers, ankle edema and nausea following a presumed insect bite on his ankle 1 month prior. On examination, he was febrile and had left leg pain with passive range of motion. Laboratory studies revealed anemia, thrombocytopenia, acute kidney injury and elevated aminotransaminases. Read More

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Rhabdomyolysis and Multisystem Organ Failure Due to Fulminant Ehrlichiosis Infection.

Wilderness Environ Med 2021 Jun;32(2):226-229

Saint Louis University School of Medicine, Division of Emergency Medicine, St. Louis, MO.

A previously healthy 51-y-old male presented to his local emergency department with subjective fevers, myalgias, dyspnea, and generalized weakness that had been progressive for several weeks. He was initially diagnosed with bilateral pneumonia, septic shock, and rhabdomyolysis requiring transfer to a tertiary care facility. He was treated for sepsis with broad-spectrum antibiotics, steroids, and a fluid bolus before transfer. Read More

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Cutaneous Plasmacytosis Associated with Ehrlichiosis in an African-American Patient.

J Clin Aesthet Dermatol 2021 Mar 1;14(3):24-27. Epub 2021 Mar 1.

Drs. Maxfield, Shah, and Muse are with Campbell University at Sampson Regional Medical Center in Clinton, North Carolina.

Cutaneous plasmacytosis is a rare disease that presents clinically with multiple red-brown papules and plaques with minimal to no epidermal change. Histopathologic findings include a perivascular dermal infiltration of polyclonal plasma cells. The etiology of cutaneous plasmacytosis is unknown, but hypothesized to be due to persistent or repeated antigenic stimulation. Read More

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Molecular detection of Rickettsia raoultii, Rickettsia tamurae, and associated pathogens from ticks parasitizing water deer (Hydropotes inermis argyropus) in South Korea.

Ticks Tick Borne Dis 2021 07 22;12(4):101712. Epub 2021 Mar 22.

College of Veterinary Medicine, Kyungpook National University, Bukgu, Daegu, 41566, South Korea; Cardiovascular Research Institute, Kyungpook National University, Junggu, Daegu, 41944, South Korea. Electronic address:

Most defined Rickettsiales, which can be transmitted by ticks, are known to be important zoonotic pathogens. Some of these pathogens can cause severe diseases in humans, including anaplasmosis, rickettsioses, and ehrlichiosis. Previous studies in South Korea have investigated tick-borne pathogens (TBPs) residing in ticks found on grassy vegetation and animals. Read More

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Likely Geographic Distributional Shifts among Medically Important Tick Species and Tick-Associated Diseases under Climate Change in North America: A Review.

Insects 2021 Mar 5;12(3). Epub 2021 Mar 5.

Biodiversity Institute, University of Kansas, Lawrence, KS 66045, USA.

Ticks rank high among arthropod vectors in terms of numbers of infectious agents that they transmit to humans, including Lyme disease, Rocky Mountain spotted fever, Colorado tick fever, human monocytic ehrlichiosis, tularemia, and human granulocytic anaplasmosis. Increasing temperature is suspected to affect tick biting rates and pathogen developmental rates, thereby potentially increasing risk for disease incidence. Tick distributions respond to climate change, but how their geographic ranges will shift in future decades and how those shifts may translate into changes in disease incidence remain unclear. Read More

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The Impact of Tick-Borne Diseases on the Bone.

Microorganisms 2021 Mar 23;9(3). Epub 2021 Mar 23.

Faculty of Dentistry, University of Toronto, Toronto, ON M5G 1G6, Canada.

Tick-borne infectious diseases can affect many tissues and organs including bone, one of the most multifunctional structures in the human body. There is a scarcity of data regarding the impact of tick-borne pathogens on bone. The aim of this review was to survey existing research literature on this topic. Read More

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Survey on tick distribution and tick-borne pathogens in Daejeon and adjacent areas in South Korea.

Ticks Tick Borne Dis 2021 07 15;12(4):101711. Epub 2021 Mar 15.

Daejeon Metropolitan City Institute of Health and Environment, 407 Daehak-ro, Yuseong-gu, Daejeon, 34142, Republic of Korea.

Ticks (Ixodidae, also known as hard ticks) as principal vectors of zoonotic diseases such as severe fever with thrombocytopenia syndrome (SFTS), Lyme borreliosis, relapsing fever, anaplasmosis, ehrlichiosis, babesiosis, coxiellosis (Q fever), and tularemia pose a major public health threat. This study was conducted to identify the distribution profile of ticks and tick-borne pathogens in Daejeon and the adjacent areas in South Korea, where no such epidemiological study has been conducted. From April to October 2019, 16,765 ticks were collected from three genera and four species: Haemaphysalis longicornis (n = 14,949; 89. Read More

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Not all lymphoid aggregates in chronic lymphocytic leukemia (CLL) patients are due to CLL!

Clin Case Rep 2021 Mar 8;9(3):1785-1786. Epub 2021 Jan 8.

Department of Pathology and Immunology Washington University School of Medicine St. Louis MO USA.

Infection is a common cause of morbidity and mortality in chronic lymphocytic leukemia and should be considered when examining bone marrow specimens to identify a potentially treatable pathogen. Read More

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Detection of and in Inhabiting Two Urban Parks in Oklahoma.

Vector Borne Zoonotic Dis 2021 May 17;21(5):385-387. Epub 2021 Mar 17.

Biology Department, University of Central Oklahoma, Edmond, Oklahoma, USA.

For the past 30 years, the number of people infected with causative agents of ehrlichiosis, Rocky Mountain spotted fever, and spotted fever group rickettiosis (SFGR) has increased in Oklahoma. However, there is a lack of data on pathogen prevalence within urban environments. To assess the prevalence of tick-borne pathogens in different environments, 434 (lone star) ticks were collected from the environment in two parks in Edmond, Oklahoma. Read More

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Infection with Dirofilaria immitis and Other Infections in Cats and Dogs from Rio de Janeiro, Brazil: The Need for Prophylactic Enforcement.

Acta Parasitol 2021 Mar 17. Epub 2021 Mar 17.

Programa de Pós-Graduação em Ética, Bioética e Saúde Coletiva, Fundação Oswaldo Cruz, Rua Leopoldo Bulhões 1480, Rio de Janeiro, RJ, 21041-210, Brazil.

Purpose: Dirofilaria immitis, a mosquito-borne nematode that primarily infects dogs, can equally infect cats. Although there have been numerous studies on canine heartworm prevalence in Brazil, there have been few studies on feline infections. Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) are both life-threatening retroviruses transmitted directly between cats. Read More

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Fever, pancytopenia, and elevated D-dimer in a 95-year-old woman with ehrlichiosis: a case report.

BMC Geriatr 2021 03 12;21(1):178. Epub 2021 Mar 12.

Yale University School of Medicine, 333 Cedar St., CT, 06510, New Haven, USA.

Background: Pancytopenia, fever, and elevated D-dimer are significant clinical findings. The differential diagnosis includes hematological malignancies, severe coronavirus disease 2019 (COVID-19), tick-borne illnesses, and other etiologies.

Case Presentation: We report the case of a 95-year-old woman who presented with high fever (103. Read More

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Primary Tick-Borne Protozoan and Rickettsial Infections of Animals in Turkey.

Pathogens 2021 Feb 19;10(2). Epub 2021 Feb 19.

Department of Parasitology, Faculty of Veterinary Medicine, Selcuk University, 42250 Konya, Turkey.

Parasitic diseases caused by ticks constitute a barrier on global animal production, mainly in tropical and subtropical regions. As a country with a temperate and subtropical climate, Turkey has topography, climate, and pasture resources, and these resources are suitable for animal breeding and parasite-host-vector relationships throughout the country. This geography restricts the regulations on animal movements in the southeastern and eastern Anatolia because of the close contact with the neighboring states. Read More

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February 2021

First Evidence of Infection in Horses from Brazil.

Pathogens 2021 Feb 25;10(3). Epub 2021 Feb 25.

Laboratory of Virology and Rickettsial Infections, Veterinary Hospital, Federal University of Mato Grosso (UFMT), Av. Fernando Correa da Costa 2367, Cuiabá 78090-900, Brazil.

The genus includes tick-borne bacterial pathogens affecting humans, domestic and wild mammals. has been identified in different animal species and geographical locations, suggesting that this is a widely distributed and generalist . In the present study, we evaluated infection in 148 Equidae presented to the Medical Clinic Department of a Veterinary Hospital from a midwestern region of Brazil. Read More

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February 2021

Insights into the mechanism regulating the differential expression of the P28-OMP outer membrane proteins in obligatory intracellular pathogen .

Emerg Microbes Infect 2021 Dec;10(1):461-471

Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, People's Republic of China.

causes human monocytic ehrlichiosis (HME), which is one of the most prevalent, life-threatening emerging infectious zoonoses. The life cycle of includes ticks and mammals, in which proteins are expressed differentially contributing to bacterial survival and infection. Among the P28-OMP outer membrane proteins, OMP-1B and P28 are predominantly expressed in tick cells and mammalian macrophages, respectively. Read More

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December 2021

Isothermal Detection of Canine Blood Parasite () Utilizing Recombinase Polymerase Amplification Coupled with Graphene Oxide Quenching-Based Pyrrolidinyl Peptide Nucleic Acid.

Bioconjug Chem 2021 03 2;32(3):523-532. Epub 2021 Mar 2.

Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Naresuan University, Tah-Poe District, Muang, Phitsanulok 65000, Thailand.

Canine monocytic ehrlichiosis (CME), caused by transmitted infection, is a major disease in dogs with worldwide distribution. Herein, a nucleic acid assay was established for the identification of infection employing a fluorescently labeled conformationally constrained pyrrolidinyl PNA probe (Flu-acpcPNA) designed to sequence-specifically target the 16S rRNA gene. The sensing principle is based on the excellent quenching ability of graphene oxide (GO) of the free PNA probe, that was diminished upon binding to the DNA target. Read More

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An innovative and user-friendly smartphone-assisted molecular diagnostic approach for rapid detection of canine vector-borne diseases.

Parasitol Res 2021 May 2;120(5):1799-1809. Epub 2021 Mar 2.

Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life and Pharmaceutical Sciences, Hainan University, Haikou, 570228, Hainan, China.

Present-day diagnostic tools and technologies for canine diseases and other vector-borne parasitic diseases hardly meet the requirements of an efficient and rapid diagnostic tool, which can be suitable for use at the point-of-care in resource-limited settings. Loop-mediated isothermal amplification (LAMP) technique has been always a method of choice in the development and validation of quick, precise, and sensitive diagnostic assays for pathogen detection and to reorganize point-of-care (POC) molecular diagnostics. In this study, we have demonstrated an efficient detection system for parasitic vector-borne pathogens like Ehrlichia canis and Hepatozoon canis by linking the LAMP assay to a smartphone via a simple, inexpensive, and a portable "LAMP box," All the components of the LAMP box were connected to each other wirelessly. Read More

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Multi-Locus Sequence Typing of Ehrlichia chaffeensis Reveals Extensive Genotypic Variation across the United States.

Am J Trop Med Hyg 2021 Mar 1. Epub 2021 Mar 1.

Ehrlichia chaffeensis causes human monocytic ehrlichiosis, and its principal vector is the Amblyomma americanum tick. The most frequently identified cases of ehrlichiosis come from the southeastern and south central states of the United States. In this study, a molecular typing system was developed that allows for the genetic differentiation of E. Read More

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Molecular Prevalence and Identification of and from Dogs in Nay Pyi Taw Area, Myanmar.

Vet Med Int 2021 8;2021:8827206. Epub 2021 Feb 8.

Department of International Relations and Information Technology, University of Veterinary Science, Nay Pyi Taw 15013, Myanmar.

Ticks are vectors of different types of viruses, protozoans, and other microorganisms, which include Gram-negative prokaryotes of the genera , , , and . Canine monocytic ehrlichiosis caused by and canine cyclic thrombocytopenia caused by are of veterinary importance worldwide. In Myanmar, there is limited information concerning tick-borne pathogens, and spp. Read More

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February 2021

Identification of and detection of tick-borne in confiscated Malayan Pangolins.

Int J Parasitol Parasites Wildl 2021 Apr 30;14:107-116. Epub 2021 Jan 30.

Guangzhou Zoo, Guangzhou, 510070, China.

Due to habitat destruction and illegal hunting and trade, the number of pangolins has been sharply reduced. To protect pangolins from extinction, relevant departments are combined and active action have been taken. A total of 21 confiscated Malayan pangolins were rescued in 2019, but died continuously for unknown reasons. Read More

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Detection of Ehrlichia sp. in Amblyomma sculptum parasitizing horses from Brazilian Pantanal wetland.

Ticks Tick Borne Dis 2021 05 19;12(3):101658. Epub 2021 Jan 19.

Laboratory of Virology and Rickettsial Infections, Veterinary Hospital, Federal University of Mato Grosso (UFMT), Av. Fernando Correa da Costa 2367, Cuiabá, MT, 78090-900, Brazil. Electronic address:

Bacteria of the genus Ehrlichia are transmitted by ticks and also are an important cause of infection in wild and domestic mammals. Infection with Ehrlichia spp. has been reported in horses, especially in the USA, Nicaragua and Brazil. Read More

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Control of ixodid ticks and prevention of tick-borne diseases in the United States: The prospect of a new Lyme disease vaccine and the continuing problem with tick exposure on residential properties.

Authors:
Lars Eisen

Ticks Tick Borne Dis 2021 05 20;12(3):101649. Epub 2021 Jan 20.

Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO, 80521, United States. Electronic address:

In the United States, exposure to human-biting ixodid ticks can occur while spending time on residential properties or in neighborhood green spaces as well as during recreational or occupational activities on public lands. Human-biting tick species collectively transmit >15 species of pathogenic microorganisms and the national burden of tick-borne diseases is increasing. The prospect of a new Lyme disease vaccine for use in humans provides hope for substantial reduction in the >450,000 estimated annual cases of Lyme disease but this breakthrough would not reduce cases of other tick-borne diseases, such as anaplasmosis, babesiosis, ehrlichiosis, spotted fever group rickettsiosis, and Powassan encephalitis. Read More

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