3,308 results match your criteria Ehrlichiosis


Serosurvey of arthropod-borne diseases among shelter dogs in the Cumberland Gap Region of the United States.

BMC Vet Res 2020 Jun 30;16(1):221. Epub 2020 Jun 30.

College of Veterinary Medicine, Lincoln Memorial University, 6965 Cumberland Gap Parkway, Harrogate, TN, USA.

Background: The Cumberland Gap Region (CGR) of the United States is a natural corridor between the southeastern, northeastern, and midwestern regions of the country. CGR has also many species of ticks and mosquitos that serve as competent vectors for important animal and human pathogens. In this study, we tested dogs from six different animal shelters in the CGR for Rocky Mountain spotted fever (RMSF), anaplasmosis, Lyme disease, canine ehrlichiosis and canine heartworm disease. Read More

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http://dx.doi.org/10.1186/s12917-020-02440-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324960PMC

Serological evaluation of selected vector-borne pathogens in owned dogs from northern Spain based on a multicenter study using a commercial test.

Parasit Vectors 2020 Jun 10;13(1):301. Epub 2020 Jun 10.

Department of Animal Medicine and Surgery, College of Veterinary Medicine, Complutense University of Madrid, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain.

Background: Environmental conditions in northern Spain allow the development of different arthropods involved in the transmission of significant canine vector-borne pathogens. The aim of the study was to systematically assess seroprevalence rates for Leishmania infantum, Ehrlichia canis, Anaplasma spp., Dirofilaria immitis and Borrelia burgdorferi, and risk factors in dogs from all regions of the north of Spain. Read More

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http://dx.doi.org/10.1186/s13071-020-04172-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288488PMC

Optimization and evaluation of a multiplex quantitative PCR assay for detection of nucleic acids in human blood from patients with spotted fever rickettsiosis, typhus rickettsiosis, scrub typhus, monocytic ehrlichiosis, and granulocytic anaplasmosis.

J Clin Microbiol 2020 Jun 3. Epub 2020 Jun 3.

Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Spotted fever group (SFGR) and typhus group (TGR) rickettsioses, scrub typhus (caused by , [OT]), ehrlichiosis, and anaplasmosis often present as undifferentiated fever but are not treated by agents (penicillins and cephalosporins) typically used for acute febrile illness. Inability to diagnose these infections when the patient is acutely ill leads to excess morbidity and mortality. Failure to confirm these infections retrospectively if a convalescent blood sample is not obtained also impairs epidemiologic and clinical research. Read More

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http://dx.doi.org/10.1128/JCM.01802-19DOI Listing

Emerging tick-borne pathogens of public health importance: a mini-review.

J Med Microbiol 2020 Jun 1;69(6):781-791. Epub 2020 Jun 1.

Department of Entomology, Rutgers University, New Brunswick, NJ, USA.

Ticks are the most important vectors of human pathogens, leading to increased public health burdens worldwide. Tick-borne pathogens include viruses (e.g. Read More

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http://dx.doi.org/10.1099/jmm.0.001206DOI Listing

Ehrlichiosis Presenting as Hemophagocytic Lymphohistiocytosis in an Immunocompetent Adult.

IDCases 2020 12;20:e00813. Epub 2020 May 12.

University of Missouri-Columbia, Department of Medicine, Division of Infectious Diseases, 1 Hospital Dr, Columbia, MO 65201, United States.

Hemophagocytic Lymphohistiocytosis (HLH) is a fatal, immunologic syndrome characterized by dysregulated tissue inflammation. HLH can be either primary or secondary; with the latter typically resulting from an infection. Diagnosis requires five or more of the following: fever, splenomegaly, cytopenia, hypertriglyceridemia, hemophagocytosis via biopsy, low natural killer (NK) cell activity, elevated ferritin and soluble CD25 level (sCD25). Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235617PMC

High Performance of ELISA test using recombinant rLiNTPDase2 from Leishmania infantum: a Phase II diagnosis of Canine Visceral Leishmaniasis.

Acta Trop 2020 May 22;209:105535. Epub 2020 May 22.

Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Av. P. H. Rolfs, s/n, Campus Universitário, CEP: 36570-000 Viçosa, MG, Brazil.

Canine visceral leishmaniasis (CVL) has been the theme of several studies given the importance of dog as natural reservoir of the pathogen Leishmania infantum in endemic regions and its role on dissemination of CVL and human visceral Lesihmaniasis (VL). The current immunodiagnosis of CVL has limitations concerning accuracy, specificity and sensitivity. Therefore, improvements are required. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105535DOI Listing

Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy.

J Obstet Gynaecol Can 2020 05;42(5):644-653

Halifax, NS.

Objective: Lyme disease is an emerging infection in Canada caused by the bacterium belonging to the Borrelia burgdorferi sensu lato species complex, which is transmitted via the bite of an infected blacklegged tick. Populations of blacklegged ticks continue to expand and are now established in different regions in Canada. It usually takes more than 24 hours of tick attachment to transfer B. Read More

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http://dx.doi.org/10.1016/j.jogc.2020.01.001DOI Listing

Predominant risk factors for tick-borne co-infections in hunting dogs from the USA.

Parasit Vectors 2020 May 13;13(1):247. Epub 2020 May 13.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, 52242, USA.

Background: Both incidence and geographical range of tick-borne disease has increased across the USA. Similar to people, dogs are hosts for Anaplasma spp., Babesia spp. Read More

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http://dx.doi.org/10.1186/s13071-020-04118-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218638PMC
May 2020
3.430 Impact Factor

Ehrlichiosis infection mimicking thrombotic microangiopathy syndrome early after kidney transplantation.

Transpl Infect Dis 2020 May 1:e13305. Epub 2020 May 1.

Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

Fever of unknown origin and the clinical picture of thrombotic microangiopathy (TMA) are diagnostic challenges in the early period after kidney transplantation. Here, we report a case of human monocytic ehrlichiosis in a renal allograft recipient who presented with fever and clinical picture of TMA in the first month post-kidney transplant. Despite broad coverage with multiple antimicrobial agents, fever and hematological abnormalities persisted for several days. Read More

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http://dx.doi.org/10.1111/tid.13305DOI Listing

Tickborne Diseases: Diagnosis and Management.

Am Fam Physician 2020 May;101(9):530-540

Naval Hospital Camp Pendleton Family Medicine Residency Program, Camp Pendleton, CA, USA.

Tickborne diseases that affect patients in the United States include Lyme disease, Rocky Mountain spotted fever (RMSF), ehrlichiosis, anaplasmosis, babesiosis, tularemia, Colorado tick fever, and tickborne relapsing fever. Tickborne diseases are increasing in incidence and should be suspected in patients presenting with flulike symptoms during the spring and summer months. Prompt diagnosis and treatment can prevent complications and death. Read More

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Ehrlichia chaffeensis Uses an Invasin To Suppress Reactive Oxygen Species Generation by Macrophages via CD147-Dependent Inhibition of Vav1 To Block Rac1 Activation.

mBio 2020 04 21;11(2). Epub 2020 Apr 21.

Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA

The obligatory intracellular pathogen lacks most factors that could respond to oxidative stress (a host cell defense mechanism). We previously found that the C terminus of surface invasin, ntry-riggering rotein of (EtpE; EtpE-C) directly binds mammalian DNase X, a glycosylphosphatidylinositol-anchored cell surface receptor and that binding is required to induce bacterial entry and simultaneously to block the generation of reactive oxygen species (ROS) by host monocytes and macrophages. However, how the EtpE-C-DNase X complex mediates the ROS blockade was unknown. Read More

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http://dx.doi.org/10.1128/mBio.00267-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175088PMC

Ehrlichiosis in a recent kidney transplant recipient: The repellent that did not repel! A case report and literature review of ehrlichiosis in solid organ transplant patients.

Transpl Infect Dis 2020 Apr 19:e13299. Epub 2020 Apr 19.

Wake Forest School of Medicine, Winston-Salem, North Carolina.

Ehrlichiosis has been infrequently reported in immunosuppressed patients such as solid organ transplants (SOT). We report a case of Ehrlichia chaffeensis infection in an immunosuppressed woman four months after deceased donor kidney transplantation. The diagnosis was confirmed by PCR testing in serum, and the patient responded promptly to treatment with doxycycline. Read More

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http://dx.doi.org/10.1111/tid.13299DOI Listing

Emerging and neglected zoonoses in transplant population.

World J Transplant 2020 Mar;10(3):47-63

Department of Virology, Croatian Institute of Public Health; School of Medicine, University of Zagreb, Zagreb 10000, Croatia.

Zoonoses represent a problem of rising importance in the transplant population. A close relationship and changes between human, animal and environmental health ("One Health" concept) significantly influence the transmission and distribution of zoonotic diseases. The aim of this manuscript is to perform a narrative review of the published literature on emerging and neglected zoonoses in the transplant population. Read More

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http://dx.doi.org/10.5500/wjt.v10.i3.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109593PMC

Tick-Borne Diseases in the United States.

Clin Chem 2020 Apr;66(4):537-548

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

Background: Tick-borne diseases are an important cause of human morbidity and mortality in the United States. The past several decades have witnessed an increase in both the number of recognized tick-borne pathogens and the number of tick-borne disease cases, whereas tick surveys have revealed substantial geographic expansions of tick populations throughout the country. Multiple laboratory testing options exist for diagnosis of tick-borne diseases, including serology, microscopy, and molecular-based methods. Read More

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http://dx.doi.org/10.1093/clinchem/hvaa040DOI Listing

Case 10-2020: An 83-Year-Old Man with Pancytopenia and Acute Renal Failure.

N Engl J Med 2020 03;382(13):1258-1266

From the Departments of Medicine (D.B.S., R.S.K.L., S.E.T.), Radiology (E.W.Z.), and Pathology (V.N., S.E.T.), Massachusetts General Hospital, and the Departments of Medicine (D.B.S., R.S.K.L., S.E.T.), Radiology (E.W.Z.), and Pathology (V.N., S.E.T.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1916250DOI Listing

Association Between Exposure to spp. and Risk of Developing Chronic Kidney Disease in Dogs.

J Am Anim Hosp Assoc 2020 May/Jun;56(3):159-164. Epub 2020 Mar 17.

From IDEXX Laboratories, Inc., Westbrook, Maine.

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http://dx.doi.org/10.5326/JAAHA-MS-7012DOI Listing

From Tick Bite to Heart Failure: Ehrlichial Myocarditis.

CJC Open 2019 Nov 4;1(6):327-329. Epub 2019 Oct 4.

The University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Cardiac involvement in myocarditis induced by Human Monocytic Ehrlichiosis infection is an incredibly uncommon complication with sparsely available literature. Also, this case highlights the importance of early recognition as a first step in management. Read More

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http://dx.doi.org/10.1016/j.cjco.2019.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063634PMC
November 2019

Discovery of Virulence Genes of Obligatory Intracellular Bacteria by Random Mutagenesis.

Front Cell Infect Microbiol 2020 4;10. Epub 2020 Feb 4.

Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, United States.

spp. are emerging tick-borne obligatory intracellular bacteria that cause febrile and sometimes fatal diseases with abnormal blood cell counts and signs of hepatitis. HF strain provides an excellent mouse disease model of fatal human ehrlichiosis. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010607PMC
February 2020

Increased Incidence of Infections in the United States, 2012 Through 2016.

Vector Borne Zoonotic Dis 2020 Jul 20;20(7):547-550. Epub 2020 Feb 20.

Department of Wildlife and Fisheries Sciences, Texas A&M University, College Station, Texas, USA.

Human ehrlichioses are tick-borne diseases that have been increasing in incidence in the United States during recent years. is one of the primary bacteria that cause ehrlichiosis in humans, which typically results in fever-like symptoms, but may also be fatal if left untreated. infections are reported to the Centers for Disease Control and Prevention (CDC) through the National Notifiable Diseases Surveillance System (NNDSS). Read More

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http://dx.doi.org/10.1089/vbz.2019.2595DOI Listing
July 2020
2.298 Impact Factor

Canine vector-borne disease in domestic dogs on Isla Santa Cruz, Galápagos.

Vet Parasitol Reg Stud Reports 2020 01 17;19:100373. Epub 2020 Jan 17.

Cornell University, College of Veterinary Medicine, 602 Tower Road, Ithaca, NY 14850, United States of America.

Vector-borne diseases result in significant morbidity and mortality in domestic dogs in tropical and subtropical regions and also pose a potential threat to wildlife species and humans. Ehrlichia canis, the causative agent of canine monocytic ehrlichiosis (CME), has a high reported seroprevalence in dogs on Santa Cruz in the Galápagos Islands, Ecuador. Veterinary diagnostic and treatment resources are often scarce and clinical follow-up is lacking in the Galápagos. Read More

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http://dx.doi.org/10.1016/j.vprsr.2020.100373DOI Listing
January 2020

Detection of Ehrlichia spp. and Anaplasma phagocytophilum in whole blood specimens using a duplex real-time PCR assay on the ARIES instrument.

Ticks Tick Borne Dis 2020 May 1;11(3):101387. Epub 2020 Feb 1.

University of Louisville, Department of Medicine, Division of Infectious Diseases, Infectious Diseases Laboratory, 511 S. Floyd St, Medical Dental Research Building Room 104, Louisville, KY 40292 USA. Electronic address:

Cases of tick-borne diseases are increasing in the United States, and new tick-borne pathogen species causing human illness are being discovered. The specific etiology is generally difficult to diagnose based on clinical signs and symptoms alone, because of their generalized nature and often lack of a known tick bite. For some infections, such as Lyme disease and spotted fever group rickettsioses, serology remains the most appropriate laboratory diagnostic tool, but for others such as anaplasmosis, ehrlichiosis, and babesiosis, direct detection in the blood is preferred for rapid diagnosis. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2020.101387DOI Listing

Molecular prevalence of in sheep from Iraq.

Open Vet J 2019 10 25;9(3):238-245. Epub 2019 Aug 25.

Department of Veterinary Internal and Preventive Medicine, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq.

Background: Tick-borne diseases are widely distributed among animal populations and are responsible for significant economic losses. However, little attention has been offered for screening such infections world widely. is among those neglected tick-borne pathogens, particularly in the developing countries. Read More

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http://dx.doi.org/10.4314/ovj.v9i3.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794391PMC
October 2019

Binding of Host Cell Surface Protein Disulfide Isomerase by Anaplasma phagocytophilum Asp14 Enables Pathogen Infection.

mBio 2020 01 28;11(1). Epub 2020 Jan 28.

Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA

Diverse intracellular pathogens rely on eukaryotic cell surface disulfide reductases to invade host cells. Pharmacologic inhibition of these enzymes is cytotoxic, making it impractical for treatment. Identifying and mechanistically dissecting microbial proteins that co-opt surface reductases could reveal novel targets for disrupting this common infection strategy. Read More

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http://dx.doi.org/10.1128/mBio.03141-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989111PMC
January 2020

Ehrlichia canis TRP36 diversity in naturally infected-dogs from an urban area of Colombia.

Ticks Tick Borne Dis 2020 May 7;11(3):101367. Epub 2020 Jan 7.

Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, Sealy Institute for Vaccine Development, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555-0609, USA. Electronic address:

Ehrlichia canis is the etiologic agent of a highly prevalent tick-borne disease, canine monocytic ehrlichiosis (CME). Four defined E. canis genotypes based on the trp36 gene sequences have been reported, three of them identified in North or South America. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.101367DOI Listing

Prevalence of Infection and Co-Infection and Presence of Rickettsial Endosymbionts in (Acari: Ixodidae) in Connecticut, USA.

J Parasitol 2020 02;106(1):30-37

Department of Environmental Sciences, The Connecticut Agricultural Experiment Station, 123 Huntington Street, New Haven, Connecticut 06511.

is currently known to transmit 7 pathogens responsible for Lyme disease, anaplasmosis, babesiosis, tick-borne relapsing fever, ehrlichiosis, and Powassan encephalitis. can also be colonized by endosymbiotic bacteria including those in the genus of . We screened 459 ticks submitted to the Connecticut Agricultural Experiment Station Tick Testing Laboratory with the objectives to (1) examine differences in infection prevalence of , , , and , (2) evaluate whether prevalence of co-infections occur at the same frequency that would be expected based on single infection, and (3) determine the presence of rickettsial endosymbionts in . Read More

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February 2020

First report of human ehrlichiosis in Turkey.

Turk J Pediatr 2019 ;61(2):267-270

Department of Public Health Institution of Turkey, National High Risk Pathogens Reference Laboratory, Ankara, Turkey.

Emiroğlu M, Çelebi B. First report of human ehrlichiosis in Turkey. Turk J Pediatr 2019; 61: 267-270. Read More

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http://dx.doi.org/10.24953/turkjped.2019.02.017DOI Listing

A retrospective study of vector-borne disease prevalence in dogs with proteinuria: Southeastern United States.

J Vet Intern Med 2020 Mar 8;34(2):742-753. Epub 2020 Jan 8.

The Department of Clinical Sciences and North Carolina State University, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

Background: Proteinuria is a risk factor for progressive kidney injury in dogs. Enhanced understanding of potential associations between canine vector-borne diseases (CVBD) and proteinuria is needed.

Objectives: To determine the proportion of evaluated proteinuric dogs exposed to ≥1 CVBD, including Babesia spp. Read More

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http://dx.doi.org/10.1111/jvim.15610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096618PMC

Seroprevalence of viral and vector-borne bacterial pathogens in domestic dogs (Canis familiaris) in northern Botswana.

PLoS One 2020 8;15(1):e0220593. Epub 2020 Jan 8.

Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, United States of America.

Background: Domestic dogs (Canis familiaris) have the potential to act as disease reservoirs for wildlife and are important sentinels for common circulating pathogens. Therefore, the infectious disease seroprevalence among domestic dogs in northern Botswana may be indicative of pathogen exposure of various wildlife species. The objective of this study was to assess the seroprevalence of Ehrlichia spp. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220593PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949005PMC

Canine vector-borne disease: mapping and the accuracy of forecasting using big data from the veterinary community.

Anim Health Res Rev 2019 06 26;20(1):47-60. Epub 2019 Sep 26.

School of Mathematical and Statistical Sciences, Clemson University, Clemson, SC, USA.

Diagnosis, treatment, and prevention of vector-borne disease (VBD) in pets is one cornerstone of companion animal practices. Veterinarians are facing new challenges associated with the emergence, reemergence, and rising incidence of VBD, including heartworm disease, Lyme disease, anaplasmosis, and ehrlichiosis. Increases in the observed prevalence of these diseases have been attributed to a multitude of factors, including diagnostic tests with improved sensitivity, expanded annual testing practices, climatologic and ecological changes enhancing vector survival and expansion, emergence or recognition of novel pathogens, and increased movement of pets as travel companions. Read More

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http://dx.doi.org/10.1017/S1466252319000045DOI Listing

Seroprevalence of Canine Ehrlichiosis and Microscopic Screening for Canine Babesiosis in Dogs in Harare, Zimbabwe, 2016-2017.

Vet Med Int 2019 1;2019:4130210. Epub 2019 Dec 1.

Department of Clinical Veterinary Studies, Faculty of Veterinary Science, University of Zimbabwe, P.O. Box MP 167, Mount Pleasant, Harare, Zimbabwe.

A cross-sectional study was done to determine ehrlichiosis seroprevalence and babesiosis prevalence in dogs that were presented to selected veterinary clinics in Harare. Sera from randomly selected dogs were tested for antibodies to spp. using an enzyme-linked immunosorbent assay while microscopy of peripheral blood smears was used to confirm babesiosis. Read More

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http://dx.doi.org/10.1155/2019/4130210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914920PMC
December 2019

Occurrence of Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti in Ixodes ricinus ticks collected from selected areas of Opolskie Province in south-west Poland.

Ann Agric Environ Med 2019 Dec 17;26(4):544-547. Epub 2019 Jul 17.

Department of Parasitology, Medical University of Silesia, Katowice, Poland.

Introduction: Ticks (Acari: Ixodida) are vectors and/or reservoirs of many pathogens, i.e. Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti. Read More

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http://dx.doi.org/10.26444/aaem/110214DOI Listing
December 2019

Phylogenetic profiling for zoonotic Ehrlichia spp. from ixodid ticks in the Eastern Cape, South Africa.

Transbound Emerg Dis 2020 May 8;67(3):1247-1256. Epub 2020 Jan 8.

Sefako Makgatho Health Sciences University, Pretoria, South Africa.

Ticks are obligate hematophagous parasite of vertebrate that transmit a range of pathogenic microorganisms that can cause diseases in livestock and humans. The range of tick-borne disease causative agents infecting domestic animals and humans has recently increased. Several significant zoonotic tick-borne diseases such as ehrlichiosis among others are on the increase worldwide. Read More

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http://dx.doi.org/10.1111/tbed.13460DOI Listing

Determining Effects of Winter Weather Conditions on Adult (Acari: Ixodidae) Survival in Connecticut and Maine, USA.

Insects 2019 Dec 21;11(1). Epub 2019 Dec 21.

Department of Entomology, Texas A&M University, TAMU 2475, College Station, TX 77843, USA.

The lone star tick ( L.) is native to the United States, with its primary range encompassing the Southeast and portions of the Midwest. It is an aggressive ectoparasite that actively seeks out hosts through detection of carbon dioxide and vibrations and can transfer ehrlichiosis-causing bacteria as well as a carbohydrate that causes alpha-gal syndrome (red meat allergy) in humans. Read More

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http://dx.doi.org/10.3390/insects11010013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023149PMC
December 2019

[Effectivity of diagnostic methods for the detection of human and canine monocytic ehrlichiosis].

Rev Chilena Infectol 2019 Oct;36(5):650-655

Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Universidad Autónoma de Yucatán, México.

Ehrlichiosis is a disease transmitted by tick's bite that affect dogs and humans caused by the species Ehrlichia canis and E. chaffeensis, respectively. These bacteria are obligated intracellular gram negatives, with a cocoid to pleomorph aspect and can infect monocytes and trigger symptoms such as high fever, anorexia, thrombocytopenia, hemorrhages, anemia, and some serious problems such as splenomegaly, hepatomegaly and meningitis. Read More

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http://dx.doi.org/10.4067/S0716-10182019000500650DOI Listing
October 2019

Prevalence and risk factors associated with infections in smallholder dairy cattle in Nairobi City County, Kenya.

Vet World 2019 Oct 24;12(10):1599-1607. Epub 2019 Oct 24.

Department of Clinical Studies, Faculty of Veterinary Medicine, University of Nairobi, Kenya.

Background And Aim: Ehrlichiosis caused by is a tick-borne disease of great economic importance in cattle production worldwide. Despite its economic impact, limited knowledge is available on its epidemiology in Africa, including Kenya. Suspected cases of infections have been reported in the recent past to the University of Nairobi's Veterinary Hospital, prompting the need to investigate their possible re-emergence. Read More

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http://dx.doi.org/10.14202/vetworld.2019.1599-1607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868257PMC
October 2019

My Mother's Story: Tick Borne Ehrlichiosis and a Life Well-Lived.

Vector Borne Zoonotic Dis 2020 May 16;20(5):319-324. Epub 2019 Dec 16.

Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.

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http://dx.doi.org/10.1089/vbz.2019.2570DOI Listing

Prevention of transmission of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum by Ixodes spp. ticks to dogs treated with the Seresto® collar (imidacloprid 10% + flumethrin 4.5%).

Parasitol Res 2020 Jan 16;119(1):299-315. Epub 2019 Nov 16.

Bayer Animal Health GmbH, 51373, Leverkusen, Germany.

The capability of imidacloprid 10% + flumethrin 4.5% (Seresto®) collars to prevent transmission of Borrelia burgdorferi sensu lato (Bbsl) and Anaplasma phagocytophilum (Ap) by naturally infected ticks was evaluated in two studies with 44 dogs. In each study, one group served as non-treated control, whereas the other groups were treated with the Seresto® collar. Read More

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http://dx.doi.org/10.1007/s00436-019-06394-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942034PMC
January 2020

Liver Is a Generative Site for the B Cell Response to Ehrlichia muris.

Immunity 2019 12 12;51(6):1088-1101.e5. Epub 2019 Nov 12.

Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address:

The B cell response to Ehrlichia muris is dominated by plasmablasts (PBs), with few-if any-germinal centers (GCs), yet it generates protective immunoglobulin M (IgM) memory B cells (MBCs) that express the transcription factor T-bet and harbor V-region mutations. Because Ehrlichia prominently infects the liver, we investigated the nature of liver B cell response and that of the spleen. B cells within infected livers proliferated and underwent somatic hypermutation (SHM). Read More

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http://dx.doi.org/10.1016/j.immuni.2019.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955021PMC
December 2019

Uncommon Ehrlichia canis infection associated with morulae in neutrophils from naturally infected dogs in Brazil.

Transbound Emerg Dis 2019 Nov 12. Epub 2019 Nov 12.

Veterinary Clinical Laboratory, Department of Veterinary Clinics, São Paulo State University (UNESP), Botucatu, Brazil.

Ehrlichia and Anaplasma species are the most common tick-borne disease (TBD) pathogens in dogs worldwide. Ehrlichia canis, the aetiological agent of the Canine Monocytic Ehrlichiosis (CME), is known to replicate within the cytoplasm of mononuclear cells into clusters of organisms called morulae. However, detection of morulae in neutrophils is commonly observed in dogs infected by Ehrlichia ewingii or Anaplasma phagocytophilum. Read More

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http://dx.doi.org/10.1111/tbed.13390DOI Listing
November 2019

Isolation and Characterization of a Novel Pathogenic Strain of .

Microorganisms 2019 Nov 5;7(11). Epub 2019 Nov 5.

UMR BIPAR, INRA, ANSES, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 94700 Maisons-Alfort, France.

The genus is composed of tick-borne obligate intracellular gram-negative alphaproteobacteria of the family Anaplasmataceae. includes important pathogens affecting canids (, , and ), rodents (), and ruminants (). , an closely related to , was initially reported in Canada and Brazil. Read More

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http://dx.doi.org/10.3390/microorganisms7110528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921006PMC
November 2019

Chemiluminescent ELISA with multi-epitope proteins to improve the diagnosis of canine visceral leishmaniasis.

Vet J 2019 Nov 21;253:105387. Epub 2019 Sep 21.

Laboratório de Leishmanioses, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

Diagnosing canine visceral leishmaniasis (CVL) is difficult because clinical signs of the disease are non-specific and a many infected animals in endemic areas, as in Brazil, are asymptomatic. Serological tests are the most common diagnostic methods employed, but most have limitations. For this reason, the implementation of a rapid, sensitive, and specific diagnostic test for CVL has become increasingly important. Read More

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http://dx.doi.org/10.1016/j.tvjl.2019.105387DOI Listing
November 2019
1 Read

Genetic diversity of Anaplasma and Ehrlichia bacteria found in Dermacentor and Ixodes ticks in Mongolia.

Ticks Tick Borne Dis 2020 Jan 21;11(1):101316. Epub 2019 Oct 21.

Division of Infectious Disease, Duke Global Health Institute, Duke University, Durham, NC, USA.

Anaplasma and Ehrlichia are tick-borne bacterial pathogens that cause human granulocytic anaplasmosis, human monocytic ehrlichiosis, and are severe threats to livestock economies like Mongolia. In this study, ticks were collected, identified, and pooled (n = 299) from three distinct environments across central Mongolia. Each pool was initially tested for Anaplasma/Ehrlichia using a 16S rRNA PCR assay that detects both genera, and specific PCR testing was done to identify those positive samples. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.101316DOI Listing
January 2020

Predicted Northward Expansion of the Geographic Range of the Tick Vector in North America under Future Climate Conditions.

Environ Health Perspect 2019 10 31;127(10):107014. Epub 2019 Oct 31.

ESCER (Étude et Simulation du Climat à l'Échelle Régionale) centre, Université du Québec à Montréal, Montréal, Québec, Canada.

Background: The geographic range of the tick , a vector of diseases of public health significance such as ehrlichiosis, has expanded from the southeast of the United States northward during the 20th century. Recently, populations of this tick have been reported to be present close to the Canadian border in Michigan and New York states, but established populations are not known in Canada. Previous research suggests that changing temperature patterns with climate change may influence tick life cycles and permit northward range expansion of ticks in the northern hemisphere. Read More

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http://dx.doi.org/10.1289/EHP5668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867274PMC
October 2019

Human Case of Ehrlichia chaffeensis Infection, Taiwan.

Emerg Infect Dis 2019 11;25(11):2141-2143

In 2018, an immunosuppressed woman in southern Taiwan had onset of fever, chills, myalgia, malaise, thrombocytopenia, lymphocytopenia, and elevated hepatic transaminases. Investigation revealed infection with Ehrlichia chaffeensis. This autochthonous case of human monocytotropic ehrlichiosis was confirmed by PCR, DNA sequencing, and seroconversion. Read More

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http://dx.doi.org/10.3201/eid2511.190665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810210PMC
November 2019

Tick Bite Risk and Tick-Borne Disease Perceptions of School District Administrators in the Mid-Atlantic United States.

J Sch Health 2019 12 14;89(12):959-968. Epub 2019 Oct 14.

Northeastern IPM Center, 340 Tower Road, Cornell University, Ithaca, NY, 14853.

Background: Lyme disease is a common tick-borne disease in the northeastern and midwestern United States. School-aged children aged 5-15 years are at high risk for contracting Lyme disease. Many school campuses in the mid-Atlantic United States are in areas that are near, or border with, wooded habitat. Read More

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http://dx.doi.org/10.1111/josh.12835DOI Listing
December 2019
2 Reads

Trends in canine seroprevalence to Borrelia burgdorferi and Anaplasma spp. in the eastern USA, 2010-2017.

Parasit Vectors 2019 Oct 14;12(1):476. Epub 2019 Oct 14.

IDEXX Laboratories, Inc., Westbrook, Maine, USA.

Background: Borrelia burgdorferi and Anaplasma phagocytophilum are tick-borne infections transmitted by Ixodes scapularis in the eastern USA; both agents cause disease in dogs and people. To characterize changes in seroprevalence over time, Cochran Armitage trend tests were used to evaluate percent positive test results for antibodies to B. burgdorferi and Anaplasma spp. Read More

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http://dx.doi.org/10.1186/s13071-019-3735-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791011PMC
October 2019
1 Read

Molecular detection of Anaplasma phagocytophilum in wild carnivores in north-eastern Poland.

Parasit Vectors 2019 Oct 7;12(1):465. Epub 2019 Oct 7.

Witold Stefański Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818, Warsaw, Poland.

Background: Anaplasma phagocytophilum is an obligate parasitic intracellular bacterium. It is the causative agent of granulocytic anaplasmosis, with effects on human and animal health. In Europe, the pathogen is mainly transmitted among a wide range of vertebrate hosts by blood-sucking arthropods. Read More

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http://dx.doi.org/10.1186/s13071-019-3734-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781336PMC
October 2019

Assessing the clinical and bacteriological outcomes of vaccination with recombinant Asp14 and OmpA against A. phagocytophilum in sheep.

Vet Immunol Immunopathol 2019 Dec 11;218:109936. Epub 2019 Sep 11.

Norwegian University of Life Sciences, Faculty of Veterinary Medicine, Department of Production Animal Clinical Science, Ullevålsveien 72, 0454, Oslo, Norway.

Anaplasma phagocytophilum is a tick borne bacterium, causing disease in sheep and other mammals, including humans. The bacterium has great economic and animal welfare implications for sheep husbandry in Northern Europe. With the prospect of a warmer and more humid climate, the vector availability will likely increase, resulting in a higher prevalence of A. Read More

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http://dx.doi.org/10.1016/j.vetimm.2019.109936DOI Listing
December 2019
1.535 Impact Factor

Laboratory Blood-Based Testing for Non-Lyme Disease Tick-Borne Infections at a National Reference Laboratory.

Am J Clin Pathol 2020 01;153(1):139-145

Quest Diagnostics, Secaucus, NJ.

Objectives: We evaluated trends in non-Lyme disease tick-borne disease (NLTBI) testing at a national reference laboratory.

Methods: Testing data performed at Quest Diagnostics during 2010 to 2016 were analyzed nationally and at the state level.

Results: Testing and positivity for most NLTBIs increased dramatically from 2010 through 2016 based on testing from a large reference laboratory. Read More

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http://dx.doi.org/10.1093/ajcp/aqz139DOI Listing
January 2020
1 Read

mTORC1-mediated polarization of M1 macrophages and their accumulation in the liver correlate with immunopathology in fatal ehrlichiosis.

Sci Rep 2019 Oct 1;9(1):14050. Epub 2019 Oct 1.

Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

A polarized macrophage response into inflammatory (M1) or regenerative/anti-inflammatory (M2) phenotypes is critical in host response to multiple intracellular bacterial infections. Ehrlichia is an obligate Gram-negative intracellular bacterium that causes human monocytic ehrlichiosis (HME): a febrile illness that may progress to fatal sepsis with multi-organ failure. We have shown that liver injury and Ehrlichia-induced sepsis occur due to dysregulated inflammation. Read More

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http://dx.doi.org/10.1038/s41598-019-50320-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773708PMC
October 2019
5 Reads
5.078 Impact Factor