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Cesk Slov Oftalmol 2021 ;77(2):73-78

Background: Ectropion and entropion are eyelid malpositions associated with a number of unpleasant symptoms. One of several surgical methods that can correct these problems is referred to as the lateral tarsal strip technique. In this paper, we evaluate the postoperative results and quality of this technique. Read More

Am J Ophthalmol 2021 May 6. Epub 2021 May 6.

Biostatistics Excellence Center, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Purpose: To compare ocular complications and efficacy of preseptal (PST) versus pretarsal (PTS) botulinum toxin type A (BoNT-A) injection in benign essential blepharospasm (BEB).

Design: Randomized clinical trial SETTING: University hospital PATIENT: Twenty-four participants with BEB were enrolled during August 2019 to June 2020. All patients and the outcome evaluator were masked to the injection allocation. Read More

Ital J Dermatol Venerol 2021 Apr;156(2):244-247

Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Reconstruction of large defects of the upper cheek defects still remains a challenge for the surgeon, who can apply different techniques. We present a new method involving the use of a dermal regeneration template to achieve an improved, faster healing of pedicled buccal fat flap in a 75-year-old woman affected by melanoma of the upper-middle cheek. The tumor involved soft tissue, zygomatic arch and periocular fact. Read More

Clin Ter 2021 05;172(3):206-208

Dermatologic Clinic, "Sapienza" University of Rome, Rome, Italy.

Abstract: Neurofibromatosis type 1 (NF1) is a rare genetic disorder with an autosomal dominant transmission and an estimated incidence of 1:2500-3500 live birth. Penetrance is virtually 100%, but the expression is highly variable and almost every organ can be affected. Diagnosis of NF1 is made with at least two of the following diagnostic criteria: six or more cafè-au-lait spots, two neurofibromas or one plexiform neurofibroma, axillary or groin freckling, optic glioma, two Lisch nodules, bone dysplasia and first-degree relative with NF1. Read More

Vet Res Forum 2021 15;12(1):133-135. Epub 2021 Mar 15.

Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Congenital ichthyosis is a disease associated with hair loss and the presence of horny plates in the epidermis, covering the whole skin. The leading cause of the disease in humans and animals is genetic disorders, and they can be found in mild and severe forms. In June 2015, a newly born calf of the Holstein breed was referred to the Livestock Veterinary Hospital internal ward, Shabestar, Iran. Read More

Cancer Med 2021 May 2. Epub 2021 May 2.

Department of Cancer Prevention, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

Risk factors of cervical cancer (CC) development are well investigated, however, those influencing the risk of a potential false negative cytology preceding diagnosis of an invasive CC are not. We have aimed to explore these factors according to the data from Organised Cervical Cancer Screening Programme (OCCSP) in Poland. A total of 2. Read More

J Cutan Aesthet Surg 2020 Oct-Dec;13(4):368-369

Department of Dermatology, Hospital Garcia de Orta, Almada, Portugal.

Saudi Med J 2021 Apr;42(4):454-456

From the Dermatology Department (Al-Khenaizan), King Abdulaziz Medical City-Ministry of National Guard; from the College of Medicine (Al-Khenaizan), King Saud Bin Abdulaziz University for Health Sciences; and from the Dermatology Department (Al-Mubarak), Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.

Clinical Presentation: A 2-month-old baby boy, of full-term spontaneous vaginal delivery, presented to the dermatology outpatient clinic with generalized erythroderma, which had been noted since birth. Family history was positive for similar disease in his eldest sister, who died at 6 months of age without a diagnosis. On examination, the patient looked ill with generalized erythroderma, yet there were no signs of ectropion, eclabium, or deformed ears. Read More

Dermatol Surg 2021 May;47(5):624-629

Department of Dermatology, University of California, Irvine, California.

Background: Laser and light-based technologies have been used in the medical field for over 50 years. In dermatologic and cosmetic practice, cutaneous side effects are commonly discussed; however, ocular injury may also occur.

Objective: To complete a systematic review of the current literature regarding ocular complications in the dermatologic field after laser and/or light-based therapies. Read More

Ren Fail 2021 Dec;43(1):465-476

Department of Urology, Institute of Urology, Gansu Nephro-Urological Clinical Center, Key Laboratory of Urological Diseases in Gansu Province, Lanzhou University Second Hospital, Lanzhou, People's Republic of China.

Objectives: To explore the mechanism of calcium-sensing receptors (CaSRs) during the development of nephrolithiasis.

Materials And Methods: Wistar rats were treated with ethylene glycol to induce calcium oxalate crystallization, and gadolinium chloride (GdCl, an agonist of CaSR) and NPS 2390 (an antagonist of CaSR) were added. Oxidative stress (OS) and calcium oxalate crystals in the kidney were observed. Read More

Cureus 2021 Jan 20;13(1):e12830. Epub 2021 Jan 20.

Oculoplastic, Orbital and Lacrimal Surgery, Aichi Medical University Hospital, Aichi, JPN.

Purpose: Facial nerve palsy is frequently associated with both epiphora and dry eye, and orbicularis oculi muscle weakness or paralysis is the main cause of these symptoms. Eyelid pressure is a quantitatively measurable parameter for evaluating the tone and function of the orbicularis oculi muscle. The aim of this study was to examine the relationship between eyelid pressure and lacrimal status in patients with mild facial nerve palsy. Read More

Eur J Ophthalmol 2021 Feb 19:1120672121995744. Epub 2021 Feb 19.

Department of Ophthalmology, The University of Alabama at Birmingham, Callahan Eye Hospital, Birmingham, AL, USA.

Purpose: To report the effect of lower eyelid temporalis fascia sling combined with lateral canthoplasty and tarsorrhaphy for paralytic ectropion.

Methods: Prospective case series of 10 patients with lower lid paralytic ectropion who were treated with lower eyelid fascia temporalis sling and lateral canthoplasty in addition to lateral tarsorrhaphy as a single-session procedure. Additional medial tarsorrhaphy was applied if the medial lower lid apposition was not adequate at the end of the procedures. Read More

J AAPOS 2020 12 24;24(6):369-371. Epub 2020 Oct 24.

Department of Ophthalmology, Singapore National Eye Centre, Singapore. Electronic address:

We describe 3 cases of unilateral congenital ectropion uveae associated with ptosis and glaucoma in a syndrome with no systemic associations. Early detection of glaucoma and timely surgical intervention is required to preserve productive vision in such patients. In our case series, trabeculectomy with mitomycin C was effective in controlling glaucoma progression over a follow-up period of 5-15 years. Read More

Ann Transl Med 2021 Jan;9(2):183

Seven Section of Department of Gynaecology, the Second Hospital of Hebei Medical University, Shijiazhuang, China.

Autosomal recessive congenital ichthyosis is a genetically and phenotypically heterogeneous group of skin disorders, including harlequin ichthyosis (HI), lamellar ichthyosis, and bullous congenital ichthyosiform erythroderma. HI is the most phenotypically severe autosomal recessive congenital ichthyosis associated with the mutation of the adenosine triphosphate-binding cassette subfamily A member 12 () gene. The clinical manifestations include generalized hyperkeratotic plaques and deep fissures, ectropion, eclabium, and contractures. Read More

Eur J Ophthalmol 2021 Feb 10:1120672121990538. Epub 2021 Feb 10.

Infectious Disease Research Center, National Institute of Respiratory Diseases, Mexico City, Mexico.

Purpose: We describe the efficacy of lateral transorbital canthopexy using a silicone tube in managing severe paralytic ectropion.

Methods: Patients with paralytic ectropion involving at least two-third of lower eyelid length and scleral exposure of 3 mm or more were considered. A silicone prosthetic was inserted during canthopexy. Read More

Ann Plast Surg 2021 03;86(3):292-297

From the Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.

Introduction: Tumors involving the lacrimal drainage apparatus can be effectively treated with oncologic eye-sparing resection, immediate reconstruction, and adjuvant radiation. The extirpative technique is well described, whereas the reconstructive approach and outcomes are limited and largely anecdotal. The present study describes the largest series in the literature evaluating outcomes after reconstruction after globe-preserving oncologic resection. Read More

Saudi J Ophthalmol 2020 Jan-Mar;34(1):59-61. Epub 2020 Nov 22.

Department of Ophthalmology, BARC Hospital, Mumbai, India.

We present a rare case of Lamellar Ichthyosis with bilateral ectropion with left sided corneal ulcer with descemetocele in a four-month-old female child, the youngest ever reported. Ichthyosis is a group of skin disorders characterized by the presence of fish-like scales all over the body (Mushriff, 2016; Turgut ., 2009). Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 01;35(1):44-48

Department of Head and Neck Surgery，Cancer Hospital Affiliated to Nantong University，Nantong，226361，China.

To investigate the clinical effect of modified V-Y advancement flap for reconstruction of facial skin defect. Thirty-eight patients with facial skin tumors underwent individual tumor resection according to pathological type and lesion depth. Based on the defect site and size, appropriate V-Y advancement flap was designed to reconstruct the skin defect in one stage. Read More

PLoS One 2021 2;16(2):e0246183. Epub 2021 Feb 2.

Tianjin Eye Hospital, Tianjin, China.

Purpose: To introduce a modified frontalis muscle (FM) flap for use in FM flap advancement surgery and compare it with the conventional flap for correcting severe congenital ptosis.

Methods: This retrospective cohort study included 200 patients (278 eyes) with severe congenital ptosis treated with FM flap advancement at Tianjin Eye Hospital from April 2018 to October 2019. The patients were divided into two groups: 100 patients (138 eyes) in the conventional group and 100 patients (140 eyes) in the modified group. Read More

J Burn Care Res 2021 Feb 2. Epub 2021 Feb 2.

Department of Ophthalmology, Department of Plastic Surgery.

Prevention and early management of post-burn cicatricial ectropion is the best strategy to avoid ocular complications, with poor visual prognosis in extreme cases. A 51-year old man presented with diminution of vision and absolute inability to close both eyes, three months after thermal burn injuries to face, upper limbs and trunk. His best corrected visual acuity (BCVA) was 1/60 in BE. Read More

Exp Eye Res 2021 Apr 23;205:108456. Epub 2021 Jan 23.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. Electronic address:

Retinoblastoma (Rb) is the most common primary intraocular childhood malignancy and one of the main causes of blindness in children. In China, most tumors are diagnosed at an advanced stage and have relatively poor outcomes compared to developed countries. Here, we aimed to update the clinical manifestations and RB transcriptional corepressor 1 (RB1) mutation spectrum in Chinese Rb patients. Read More

Ophthalmology 2021 Feb;128(2):233

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.

Ophthalmic Plast Reconstr Surg 2021 Jan 19. Epub 2021 Jan 19.

Department of Ophthalmology Department of Dermatology, Duke University, Durham, North Carolina.

Purpose: To describe postoperative management following ablative carbon dioxide laser resurfacing of the lower eyelids.

Methods: A retrospective review of patients who consecutively underwent bilateral lower eyelid ablative carbon dioxide laser resurfacing by a single experienced oculoplastic surgeon over a 6-year period was conducted. Patient satisfaction, aesthetic outcomes, and postoperative complications were evaluated as adjunctive or monotherapy. Read More

Endocr Metab Immune Disord Drug Targets 2021 Jan 14. Epub 2021 Jan 14.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran. Iran.

Kabuki syndrome is a rare congenital anomaly/mental retardation syndrome characterized by intellectual disability, developmental delay, short stature, facial dysmorphic features including ectropion of the lateral third of the lower eyelids and long palpebral fissures, and prominent finger pads. Pathogenic variants of KMT2D (MLL2) and KDM6A are found to be the major causes of Kabuki syndrome. Here, we report the first Iranian case with Kabuki syndrome with an IQ of 79, two episodes of viral pneumonia and distinctive facial features, prominent ears and persistent fetal fingertip pads. Read More

Acta Clin Croat 2020 Jun;59(2):377-381

1Faculty of Medicine in Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 2Department of Maxillofacial and Oral Surgery, Osijek University Hospital Centre, Osijek, Croatia; 3Department of Ophthalmology, Osijek University Hospital Centre, Osijek, Croatia.

Blepharospasm is an idiopathic condition characterized by involuntary eyelid closure mainly caused by bilateral tonic-clonic contractions of the orbicularis oculi muscle. It results in patient inability to open their eyes, thus significantly impairing their ability to perform activities of daily living. First-line treatment for blepharospasm are primarily botulinum toxin type A injections. Read More

Eye (Lond) 2021 Jan 11. Epub 2021 Jan 11.

Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF, UK.

Background/objectives: To evaluate the outcomes of orbital evisceration with primary implant placement in acutely infected/inflamed eyes, using implant exposure/extrusion as a surrogate of success. To contextualise this with previously published literature.

Subjects/methods: A retrospective case series of all patients with acutely infected/inflamed eyes undergoing urgent orbital evisceration with primary implants, at a British tertiary centre between January 2006 and August 2018. Read More

World J Clin Cases 2020 Dec;8(24):6274-6281

Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital of Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing 100730, China.

Background: In children, it is common to see failure and recurrence in the correction of epiblepharon and to have reoperation due to obvious irritation symptoms and corneal injury.

Aim: To explore the causes of failure and recurrence after epiblepharon correction in children, to remove accurately redundant epiblepharon and orbicularis oculi muscle in patients the cilia-everting suture technique combined with lid margin splitting in some patients due to inverted lashes in the medial part of the eyelid, and to observe the therapeutic effect.

Methods: From 2015 to 2019, in the Outpatient Department of Ophthalmology of Beijing Tongren Hospital, 22 children (40 eyes) with epiblepharon, aged 5-12 years, were treated due to correction failure and recurrence. Read More

J Plast Reconstr Aesthet Surg 2021 Apr 29;74(4):730-739. Epub 2020 Dec 29.

Division of Plastic Surgery, McMaster University, Hamilton, Canada.

Purpose: Cervicofacial flaps represent an excellent option for coverage of cheek defects secondary to oncologic resection, trauma or infection. However, there remains clinical equipoise regarding whether superficial plane or deep plane dissection results in the lowest rates of complications and optimal outcomes.

Methods: A systematic review and meta-analysis of proportions was conducted to assesses outcomes between cheek reconstruction superficial plane or deep plane cervicofacial flaps. Read More

GMS Ophthalmol Cases 2020 26;10:Doc44. Epub 2020 Nov 26.

Department of Ophthalmology, Government Medical College, Chandrapur, Maharashtra, India.

This report describes a clinically rare case of congenital ectropion involving both upper lids in a one-day-old Indian newborn. We emphasize the importance of non-invasive conservative management with 5% hypertonic saline. Observational case report A term newborn presented to us on day 1 with bilateral upper lid ectropion or 'double congenital ectropion' noted since birth following an uneventful vaginal delivery. Read More

Plast Aesthet Res 2020 20;7. Epub 2020 Nov 20.

Division of Oculofacial Plastic and Reconstructive Surgery, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami-Miller School of Medicine, Miami, FL 33136, USA.

Laser (light amplification by the stimulated emission of radiation) skin resurfacing is currently one of the most widely adopted technologies in facial rejuvenation. While most often used for aesthetic purposes, lasers also have applications in the management of scars. Since the introduction of the CO laser for skin rejuvenation in the 1990s, the last three decades have seen significant growth in the number of laser devices available to the physician. Read More